Digital Commons Network^™

Development Of Localized Drug Delivery Strategies For The Treatment Of Cancers And Infectious Diseases, Weizhou Yue

Open Access Dissertations

Difficult-to-treat human diseases and disorders such as brain cancer and posterior segment eye diseases greatly threaten human health and quality of life. However, the presence of physiological barriers such as the blood-brain barrier (BBB), cornea, and the blood-retinal barrier, renders these organs highly impervious to most therapeutics. As a result, most therapeutics administered systemically have low therapeutic efficacy even with high doses and are often associated with systemic side effects and/or toxicity. Localized drug delivery strategies such as injectables/implants, or locally-acting dosage forms, can circumvent physiological barriers and directly introduce therapeutics to the site of action to improve bioavailability, and …

The Influence Of Nutrient Regime On Diatom Diversity And Diatom Diazotroph Associations, Samantha Patricia Setta

Open Access Dissertations

Phytoplankton are important primary producers at the base of the marine food web. Diatoms are one of the most diverse groups of phytoplankton. Compared to other phytoplankton, diatoms have higher nutrient requirements due to their larger size, and as such, their distribution is limited by nutrients. Because of this, diatoms thrive in high-nutrient ocean regions, such as coastal and high-latitude waters, where the bulk of prior diatom research has occurred. However, diatoms are also found in low-nutrient oligotrophic waters, where they can form blooms and contribute up to 30% of total annual carbon sequestration. Many studies have documented the metabolic …

Development Of Polymeric Nano- And Microparticle-Based Controlled Release Platforms, Ryan Ivone

Open Access Dissertations

The success of the development of drug delivery formulations hinges upon their ability to maintain therapeutic efficacy, while simultaneously aiming to minimize off-site side effects and reduce the dosing burden often faced by patients. Localized formulations deliver therapeutics directly to the disease site and can help circumvent physiological obstacles such as the first pass effect, which remains one of the primary barriers for oral drug delivery. Barriers such as the first pass effect can drastically reduce the overall bioavailability of a formulation, potentially requiring a higher initial dose to remain therapeutically effective. However, many compounds demonstrate dose dependent side effects, …

Flux To Flow: A Clearer View Of Earth’S Water Cycle Via Neural Networks And Satellite Data, Albert Eric Larson

Open Access Dissertations

Earth’s weather and climate changes dynamically, and humans must monitor the evolution of our environment or fail to plan and adapt. Water is our most valuable resource, and as such it is of the utmost importance to have a continuous view of its movements as water cycles over, in, and under land, in the atmosphere, and in the sea. One way that we observe the water cycle is with satellite measurements. Unfortunately, the resolution of these instruments is typically too coarse to visualize many transient phenomena of interest. If their vision is fine enough, the instrument captures only a small …

The (Mis)Formation Of Identity In Joseph Conrad’S Novels: Ideology, Community, And The Self, Youngji Cho

Open Access Dissertations

Joseph Conrad’s Heart of Darkness, Nostromo, and The Secret Agent contain two broad themes: on the one hand, they critically portray the dominant influence of society or societal ideologies on the individual from a socio-political standpoint; on the other hand, they focus on the (dis)illusion of the protagonists regarding their own “ideal” identities from a personal standpoint. Rather than addressing one or the other, as many previous studies of Conrad’s novels have done, this dissertation argues for the intimate continuity between socio-political ideologies and personal identity by finding the point of contact between these two seemingly disparate issues. …

Microfluidic Paper-Based Devices For The Detection Of Chemical And Biological Agents, Hojat Heidaribafroui

Open Access Dissertations

This work was motivated by two needs: to develop low-cost, high-sensitivity, and accurate systems for detecting phosphate in seawater, and to create a platform technology by integrating Bi-Material Cantilever (B-MaC) valves for rapid and affordable biosensors that can be used at home or point-of-care settings to detect pathogens.

Detecting low levels of phosphate in the seawater using an inexpensive sensor is crucial for marine scientists to make informed decisions on where to measure next, compared to the current method of collecting samples and analyzing them ashore. To address these needs, we developed a portable infrared lightbox that can be wirelessly …

Computational Close Reading: A Critique Of Digital Literary Methodology, Damiano Consilvio

Open Access Dissertations

Computational Close Reading intervenes in digital humanities and American literary scholarship to negotiate a significant institutional and disciplinary problem: the devaluation of close reading and interpretation in digital humanities applications to literary studies in favor of more distant modes of reading. To remedy this issue, I pursue a core question meant to bring the literary and the digital into a more perfect confluence, as a demonstration of possibilities meant to run counter to these preconceptions about computational reading: how “close,” if close at all, can digital technologies bring us to the interpretive elements of literary texts? I argue that they …

Clonal Diversity, Antibiotic Resistance, And Virulence Factor Prevalence Of Community Associated Staphylococcus Aureus In Southeastern Virginia, Katelyn D. Cranmer, Mohan D. Pant, Suzanne Quesnel, Julia A. Sharp

EVMS School of Health Professions Faculty Publications

Staphylococcus aureus is a significant human pathogen with a formidable propensity for antibiotic resistance. Worldwide, it is the leading cause of skin and soft tissue infections (SSTI), septic arthritis, osteomyelitis, and infective endocarditis originating from both community- and healthcare associated settings. Although often grouped by methicillin resistance, both methicillin-resistant (MRSA) and methicillin-sensitive (MSSA) strains are known to cause significant pathologies and injuries. Virulence factors and growing resistance to antibiotics play major roles in the pathogenicity of community-associated strains. In our study, we examined the genetic variability and acquired antibiograms of 122 S. aureus clinical isolates from SSTI, blood, and urinary …

Muscovy Duck (Cairina Moschata), M. J. Robinson, S. K. Robinson, Ann Hodgson, Florida Ornithological Society

Family 01: Anatidae

Of the roughly 100 bird species introduced to Florida over the years, 14 are considered established species, including the Muscovy Duck. The native range of this large, bulky duck species includes Central and South America, Mexico, and the southernmost regions of Texas.

How The Supreme Court Ghosted The Phosita: Amgen And Legal Constructs In Patent Law, Timothy R. Holbrook, Mark D. Janis

Articles by Maurer Faculty

This Essay is an invited response to The Ghost in the Patent System: An Empirical Study of Patent Law’s Elusive “Skilled Artisan,” by Professors Laura Pedraza-Fariña and Ryan Whalen. In their piece, Pedraza-Fariña and Ryan Whalen offer an empirical study and use it to argue for a new conception of the Person Having Ordinary Skill in the Art (“PHOSITA”), patent law’s nod to the “reasonable person” construct.

As Professors Pedraza-Fariña and Whalen suggest, the PHOSITA should be understood as a crucial concept in patent law, warranting more scholarly attention. Pedraza-Fariña and Whalen provide that attention. They assert, based on an …

2022-23 Annual Report, Tennessee. Wildlife Resources Agency

Annual Reports

This annual report presents an overview of the Tennessee Wildlife Resources Agency programs and management.

Application Of Metagenomic And Molecular Microbiology Techniques To Elucidate Sources Of Fecal Pollution And Anthropogenic Antibiotic Resistance Genes To Surface Water: A Step Towards A “One Health” Approach To Watershed Management, Mehedi Hasan Tarek

Graduate Theses, Dissertations, and Problem Reports (ETD)

The use of fecal indicator bacteria, such as Escherichia coli, is a widely established regulatory and monitoring practice to detect surface water contamination associated with fecal pollution. However, the detection or quantification of fecal indicator bacteria alone does not accurately inform the sources of fecal pollution. The development of molecular and metagenomic methods that target the DNA of microorganisms has resulted in a host of new tools for monitoring fecal pollution and its sources, as well as for understanding emerging microbial threats, such as antimicrobial resistance. Antimicrobial resistance is a critical “One Health” challenge presenting a high risk to …

Shear Bond Strength Comparison Of Bioceramics To Root Dentin., Yasmin Alma Hoffman

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction: The purpose of this study is to compare the push-out bond strength of four bioceramic materials to root dentin that are used during regenerative endodontics. The bioceramics being tested are: 1. Biodentine®(Septodont); 2. EndoSequence BC Putty Fast Set® (Brasseler); 3. NeoPutty® (Avalon Biomed); and 4. ProRoot MTA White® (Dentsply). A high bond strength of a bioceramic material to root dentin will provide excellent seal. An improved seal may correlate with less potential for contamination of the pulp space that is undergoing regenerative activity. This in turn will lead to long-term clinical success. The null hypothesis is that there is …

Forage Grass Growth Habit And Allelopathy In Birdsfoot Trefoil Germination And Establishment, Nathan El Blake

Graduate Theses, Dissertations, and Problem Reports (ETD)

Birdsfoot trefoil (Lotus corniculatus L.) (BFT) is a high quality, tanniniferous forage legume that has been shown to mitigate gastrointestinal nematode (GIN) infection in sheep. Reliable establishment of birdsfoot trefoil in existing pastures is difficult due to BFT’s poor seedling vigor, susceptibility to crown and root rot, and, perhaps chiefly, competition from other pasture plants. Most existing pastures in the Northeastern United States are primarily composed of cool-season grasses, many of which can be highly competitive. A common form of interplant competition is allelopathy, which occurs when secondary metabolites produced by a plant inhibit a necessary growth process of …

Analysis Of Experimental Antimicrobial Prevention Strategies Against Microbial Contamination Of Locally Harvested Poultry And Produce In West Virginia, Rebecca Breanne Stearns

Graduate Theses, Dissertations, and Problem Reports (ETD)

Fresh produce and poultry have been associated with several foodborne illness outbreaks. Strategies to mitigate these risks are a much-needed research priority; therefore, five experiments were conducted to analyze pathogen cross-contamination capabilities on produce and poultry. Microbial contamination prevention and reduction strategies were also studied.

In Chapter Two, three antimicrobial delivery methods in combination with increasing concentrations of hydrogen peroxide-peroxyacetic acid (H₂O₂-PAA) (0.05-0.25 ml/dL) were compared to evaluate their ability to reduce and prevent cross-contamination of Listeria monocytogenes (L. monocytogenes) and Listeria innocua (L. innocua) on inoculated apples. Apples have been …

“Courting Anarchy”: Roman Catholic Diocese Of Brooklyn V. Cuomo (2023), Shannon Leonard

UIC Law Review

No abstract provided.

Ce 432 Syllabus: Stress Management, Karen Cathey

Counselor Education Syllabi

This course will provide an introduction to important concepts, issues, skills, and interventions related to the identification and management of personal stress.

Ce 611 Syllabus: Development Over The Lifespan, Anquinetta V. Calhoun

Counselor Education Syllabi

The purpose of this course is to promote students’ thinking and learning about human growth, adaptation, and change throughout the lifespan. Major theories, issues, eras, and trends in human development will be addressed.

The Right To Personality: Navigating The Brave New World Of Personality-Altering Interventions, Christopher S. Sundby

Connecticut Law Review

As neuroscience progresses, policy makers will have an increasing arsenal of behavior-modifying interventions at their disposal to deploy in the hopes of reducing recidivism and making the criminal justice system more rehabilitative. While these interventions are promising, they also can pose grave risks to individual liberty interests that are insufficiently acknowledged, much less protected, by current jurisprudence. Specifically, the current legal regimes and proposed alternatives either fail to identify the nature of the liberty at stake by overly focusing on physical side effects to the exclusion of thought- and personality-altering side effects, reject completely the potential for these interventions to …

Resilience Grammar: A Value Sensitive Design Method For Resilience Thinking, David G. Hendry, Batya Friedman

Tech Policy Lab

The resilience grammar is a method for bringing a value sensitive design sensibility to resilience thinking. The method provides a systematic process for researchers, designers, and policymakers to identify and trace resilience pathways in the context of real world responses to stressors and obstacles. The grammar is composed of seven statement types, which bring forward aspects of resilience. Each statement type is composed of a connecting phrase and an element, in the form of “resilience connecting-phrase .” In this report, we define each statement type in the resilience grammar, provide two brief illustrations of the grammar in action, and conclude …

Tattoos, Norms, And Implied Licenses, Aaron Perzanowski

Minnesota Law Review Headnotes, Vols. 107 onward (2022-present)

No abstract provided.

The Battle For The Soul Of The Gdpr: Clashing Decisions Of Supervisory Authorities Highlight Potential Limits Of Procedural Data Protection, Jordan Francis

Minnesota Law Review Headnotes, Vols. 107 onward (2022-present)

No abstract provided.

Narrative Report Of The Town Officers Of Amherst, New Hampshire, For The Year Ending December 31, 2022, And Financial Records For Fiscal Year Ending June 30, 2022., Amherst Town Representatives

Amherst, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Temple, New Hampshire 2022 Annual Report For The Year Ending December 31, 2022., Temple Town Representatives

Temple, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Annual Report Of The Town Office Of Dalton, New Hampshire For The Year Ending December 31, 2022, Dalton Town Representatives

Dalton, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Annual Reports Of The Selectmen, Treasurer, Collector Of Taxes, Town Clerk, Trustees Of The Trust Funds, All Other Town Officers, And The School Board Of The Town Of South Hampton, Nh, For The Year Ending December 31st, 2022, South Hampton Town Representatives

South Hampton, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

City Of Berlin, Nh, Annual Report, Fiscal Year July 1, 2021 To June 30, 2022., Berlin Town Representatives

Berlin, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Town Of Colebrook Annual Town Report Year Ending December 31, 2022., Colebrook Town Representatives

Colebrook, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

The Effectiveness Of The Teaching Interaction Procedure For Young Children With Developmental Delay, Bailey Nicole Swain

Dissertations and Theses

Developmental Delay (DD) is an IDEA classification for young children who fail to meet developmental milestones at typical times. Young children with delays in social or emotional development may show deficits in social skills. Noting the importance of early intervention, identifying effective social skills interventions for children aged 3-5 is essential. Kopp et al. (1992) note the differences in social skills between preschoolers with DD and typically developing peers. This study investigated the effects of the Teaching Interaction Procedure on skill acquisition and generalization to a free play activity in the general education classroom.

Teen Appeal, Memphis, 04.04, 2000

Documents

Issue 4.4 of the “Teen Appeal” published by the University of Memphis Journalism Department and Commercial Appeal, Memphis, Tennessee, on December 5, 2000.