Digital Commons Network^™

Building Consensus Around The Assessment And Interpretation Of Symbiodiniaceae Diversity, Cawa Tran, Et Al.

Biology: Faculty Scholarship

Within microeukaryotes, genetic variation and functional variation sometimes accumulate more quickly than morphological differences. To understand the evolutionary history and ecology of such lineages, it is key to examine diversity at multiple levels of organization. In the dinoflagellate family Symbiodiniaceae, which can form endosymbioses with cnidarians (e.g., corals, octocorals, sea anemones, jellyfish), other marine invertebrates (e.g., sponges, molluscs, flatworms), and protists (e.g., foraminifera), molecular data have been used extensively over the past three decades to describe phenotypes and to make evolutionary and ecological inferences. Despite advances in Symbiodiniaceae genomics, a lack of consensus among researchers with respect to interpreting genetic …

Changes In The Microbiome Of The Sea Anemone Exaiptasia Diaphana During Bleaching From Short-Term Thermal Elevation, Jamison R. Sydnor, Jamie Lopez, Gordon V. Wolfe, Lisa Ott, Cawa Tran

Biology: Faculty Scholarship

We examined the response of microbial communities in the model sea anemone Exaiptasia diaphana (Aiptasia) to short-term thermal elevation. Through 16S rRNA gene sequencing, we characterized the microbiomes of symbiotic (with algal symbionts) and aposymbiotic (bleached) anemones under ambient (27°C) and heat-stressed (34°C) conditions for 8-10 days, using both replicated endpoint and non-replicated time-course approaches. Consistent with prior studies, we observed a stable abundance of bacteria from the families Alteromonadaceae and Rhodobacteraceae, though with wide variation among individual anemones. We observed that symbiotic state conferred a larger impact on the microbiome than heat stress, implying the microbiome may play a …

Gestational Vulnerability To Ozone Air Pollution - A Placental Story, Vishnupriya Alavala, Sarah Brent, Russell Hunter, Matthew J. Campen, Andrew Ottens

UROP Posters

About 99% of the global population resides in areas with air pollution surpassing World Health Organization standards. Air pollution is associated with adverse neonatal health outcomes such as low fetal birth weight and an increased risk for maternal pre-eclampsia. A particularly reactive air pollutant is ozone, which forms reactive oxygen species that induce cellular damage. Research exists on the dispersion of reactive oxygen species through the bloodstream leading to fetal vulnerability during pregnancy, specifically via the placenta. Yet, placental and fetal development is a temporal process with varied susceptibility to negative gestational outcomes.

To addressing this gap, our laboratory utilized …

Proposing An Rna Interference (Rnai)-Based Treatment For Human Immunodeficiency Virus (Hiv) By Analyzing The Post-Transcriptional Gene Targeting Of Sars-Cov-2, Hepatitis C Virus, And A549 Lung Cancer Cells, Arjun Jagdeesh

UROP Posters

Human Immunodeficiency Virus (HIV) is a retrovirus that infects CD4+ T cell lymphocytes in humans, leading to the development of Acquired Immunodeficiency Syndrome (AIDS) if left untreated. While current treatment methods, including antiretroviral combination treatments, effectively limit HIV replication, HIV can evade these treatments due to its high mutation rate. Long-term antiretroviral treatment can also be toxic to patients, meaning patients would benefit from a new mechanism of HIV treatment. RNA interference (RNAi) is an antiviral pathway found in mammals, plants, and insects that involves a small-interfering RNA that is incorporated into a protein complex called the RNA-induced Silencing Complex …

Patient-Specific Analysis Of Aortic Hemodynamics And Wall Shear Stresses In Patients Undergoing Pediatric Bariatric Surgery Using 2d Phase-Contrast Mri, Oluwaferanmi S. Akande, Joao Soares, Nathan Hargan, Dr. Uyen Truong, Haeung Kang, David Lanning

UROP Posters

Patient-Specific Analysis of Aortic Hemodynamics and Wall Shear Stresses in Patients Undergoing Pediatric Bariatric Surgery using 2D Phase-Contrast MRI

Feranmi Akande¹ Nathan Hargan² Haesung Kang³ David Lanning³ Uyen Truong⁴ João S. Soares¹

¹ Department of Biomedical Engineering, College of Engineering, Virginia Commonwealth University

² Department of Mechanical & Nuclear Engineering, College of Engineering, Virginia Commonwealth University

³ Department of Cardiology, Children’s Hospital of Richmond, Virginia Commonwealth University

Introduction: Severe obesity among today’s youth is a rising epidemic within the United States. Emerging research has linked childhood obesity with shortened life expectancy and early …

Blue Brief 2022-2023, University Of San Diego School Of Law

Blue Brief

A USD School of Law faculty review of selected rulings from the most recent Term of the United States Supreme Court.

Situational Analysis And Urban Theory, Mark Davidson

Geography

Urban geographers have been pursuing divergent theoretical projects. Some have pushed urban theory to become ageographical, the goal being to search out and explain of a globally omnipotent urbanization process. Others have moved in a different direction, seeking to detail how singular constellations of processes produce only particular urban places. This theoretical divergence has led some to question whether middle-range urban theories continue to have purchase today. This paper seeks to contribute to this attempt to rekindle an interest in middle-range urban theory by examining the relevance of Karl Popper’s situational analysis to how we understand contemporary urbanization. © The …

Female And Male Leach's Storm Petrels (Hydrobates Leucorhous) Pursue Different Foraging Strategies During The Incubation Period, Robert A. Mauck, Isabeau Pratte, April Hedd, Ingrid L. Pollet, Patricia L. Jones, William A. Montevecchi, Robert A. Ronconi, Carina Gjerdrum, Sarah Adrianowyscz, Colin Mcmahon, Haley Acker, Liam U. Taylor, Jennifer Mcmahon, Donald Dearborn, Gregory J. Robertson, Laura A. Mcfarlane Tranquilla

All Faculty Scholarship

Reproduction in procellariiform birds is characterized by a single egg clutch, slow development, a long breeding season and obligate biparental care. Female Leach's Storm Petrels Hydrobates leucorhous, nearly monomorphic members of this order, produce eggs that are between 20 and 25% of adult bodyweight. We tested whether female foraging behaviour differs from male foraging behaviour during the ~ 44-day incubation period across seven breeding colonies in the Northwest Atlantic. Over six breeding seasons, we used a combination of Global Positioning System and Global Location Sensor devices to measure characteristics of individual foraging trips during the incubation period. Females travelled significantly …

Individual-Based Models Of Avian Migration For Estimating Behavioural Traits And Predicting Ecological Interactions, Benjamin A. Tonelli, Alan E. Zelin, Donald Dearborn, Morgan W. Tingley

All Faculty Scholarship

Rapid advances in the field of movement ecology have led to increasing insight into both the population-level abundance patterns and individual-level behaviour of migratory species. Despite this progress, research questions that require scaling individual-level understanding of the behaviour of migrating organisms to the population level remain difficult to investigate. To bridge this gap, we introduce a generalizable framework for training full-annual cycle individual-based models of migratory movements by combining information from tracking studies and species occurrence records. Focusing on migratory birds, we call this method: Models of Individual Movement of Avian Species (MIMAS). We implement MIMAS to design individual-based models …

Climate Services And Transformational Adaptation, Edward Carr

Sustainability and Social Justice

The Working Group II contribution to the IPCC’s Sixth Assessment Report states that effective adaptation to the changing climate will require transformational changes in how people live. This article explores the potential for climate services to catalyze and foster transformational adaptation. I argue that weather and climate information are not, in and of themselves, tools for transformation. When designed and delivered without careful identification of the intended users of the service and the needs that service addresses, they can fail to catalyze change amongst the users of that information. At worst, they can reinforce the status quo and drive maladaptive …

“Bhat Khaiso?”: The Role Of Food In A Bangladeshi Community In The U.S., Jinia Meherin , '23

Senior Theses, Projects, and Awards

No abstract provided.

Formulaicity And Contexts: A Multimodal Analysis Of The Japanese Utterance-Final Tteyuu, Michiko Kaneyasu

World Languages and Cultures Faculty Publications

This study investigates the use of the utterance-final tteyuu [ʔtejɯː], a combination of the quotative particle tte and the verb yuu (‘say’). Although its lexicalized status and utterance-final occurrence are commonly observed, we still know little about its real-time functions. The analysis of 120 examples in varied contexts shows its general usage to clarify something expressed in the prior talk, which is a type of repair practice. More importantly, the analysis reveals how the participants’ understanding of the ongoing speech activity and multimodal cues affect its use and interpretation. Furthermore, some specialized usages appear to motivate activity-bound pragmatic inferencing, leading …

On Respect For Robots, Daniel Tigard

Philosophy: Faculty Scholarship

We spend a lot of time with robotic and artificially intelligent (AI) technologies today. At the same time, it appears that we are growing more accustomed to interacting with AI and robots as if they were fellow human beings. Such trends have aptly brought about increasing ethical discussions concerning how we should treat technological devices. Do we owe robots some degree of respect, and how could respecting robots be justified? With this article, I put forward a new way of answering these questions. I invoke a revisionist account of Kant’s ethics that amends the usual priority of dignity before respect …

Polymer Threadings And Rigidity Dictate The Viscoelasticity Of Entangled Ring-Linear Blends And Their Composites With Rigid Rod Microtubules, Karthik R. Peddireddy, Ryan Clairmont, Rae M. Robertson-Anderson

Physics and Biophysics: Faculty Scholarship

Mixtures of polymers of varying topologies and stiffnesses display complex emergent rheological properties that often cannot be predicted from their single-component counterparts. For example, entangled blends of ring and linear polymers have been shown to exhibit enhanced shear thinning and viscosity, as well as prolonged relaxation timescales, compared to pure solutions of rings or linear chains. These emergent properties arise in part from the synergistic threading of rings by linear polymers. Topology has also been shown to play an important role in composites of flexible (e.g., DNA) and stiff (e.g., microtubules) polymers, whereby rings promote mixing while linear polymers induce …

Winternitz 001 (2023), Marina Winternitz

Grado en Diseño de Moda

Durante siglos, los productos hechos a máquina y los artesanales han vivido un conflicto constante. Los que valoran el trabajo artesanal rehúsan el empleo de maquinaria pesada y complicada, mientras que los que están acostumbrados a una forma más rápida de trabajar puede que la ralentización no les merezca la pena. Cuando una de estas formas de producción empieza a subir, la otra le sigue para luchar contra la corriente. En el mundo de la moda, la dicotomía entre productos hechos a máquina y a mano caracteriza los procesos de producción de la alta costura y el prêt-à -porter. El …

Uve 15 (2023), Claudia Pintado Morales

Grado en Diseño de Moda

Este proyecto consiste en la creación de un portfolio de moda de autor femenina en el que prima la elaboración de nuevos textiles sostenibles. Al ser la sostenibilidad un punto fundamental en todo el proceso, se partirá de la experimentación con materiales en esa línea. Entre ellos encontramos la kombucha para elaboración de cuero vegano, el alginato, distintas elaboraciones con bioplásticos, fibras de lana sin tratar o tintes naturales. Para llevar a cabo dicho trabajo, se realizará una investigación. Primeramente se analizará el mercado desde un panorama global hasta un panorama nacional, de la misma manera que se hará un …

Review On Molecular Genetic Basis Of Hypertrophic Cardiomyopathy, Derek Pok Him Lee

Journal of the Hong Kong College of Cardiology

Hypertrophic cardiomyopathy (HCM) is one of the most common types of inherited cardiomyopathy with a wide range of clinical manifestations ranging from subtle myocardial hypertrophy to debilitating heart failure, cardiac arrhythmias, and sudden cardiac death. We reviewed the literature on the latest knowledge regarding the pathophysiology and molecular genetic basis of HCM. This will include laboratory studies on animal models and human pluripotent stem-cell derived cardiomyocytes and the theory of proximal mechanisms involving calcium handling and energy expenditure underlying HCM. The current review will also illustrate the pathogenicity of various associated genetic variants, genotype-phenotype correlation and the optimal approach to …

Asia Pacific Perspectives Vol. 18 No 1. 2023, University Of San Francisco

Asia Pacific Perspectives

Contents:

Articles

Urban Youth on the Margins: Inequality in China’s Sent Down Youth Movement by Sanjiao Tang

Chinese Firms in the Belt and Road Initiative: A Cross-Sectoral Study of BRI Activities in Kenya by Yabo Wu

Book Review

W. Puck Brecher. Animal Care in Japanese Tradition: A Short History by James Stone Lunde

Proper Parties, Proper Relief, Samuel L. Bray, William Baude

Journal Articles

From the Introduction

In the last Term at the United States Supreme Court [2022], standing was the critical question in several major cases: the two challenges to the Biden Administration’s first student loan forgiveness plan, Biden v. Nebraska and Department of Education v. Brown, as well as the challenge to the Administration’s immigration priorities in United States v. Texas and the race-discrimination challenge to the Indian Child Welfare Act in Haaland v. Brackeen. Standing has featured heavily in journalistic coverage of the decision in 303 Creative LLC v. Elenis. And standing may have been the reason for the Court’s stay …

Shared Decision-Making In Multiple Sclerosis Physical Symptomatic Care: A Systematic Review, Aliza Bitton Ben-Zacharia, Jong-Mi Lee, Jennifer S. Kahle, Bonnie Lord

Psychological Sciences: Faculty Scholarship

Background: Multiple sclerosis (MS) is a chronic autoimmune inflammatory, demyelinating, and neurodegenerative disease affecting young adults. People with MS are highly interested in engaging in physical symptom management and decision-making but are often not actively engaged in symptom management discussions. Research examining the benefit of shared decision-making in the management of physical MS symptoms is sparse. Objectives: This study aimed to identify and synthesize the evidence on the use of shared decision-making in physical MS symptom management. Design: This study is a systematic review of published evidence on the use of shared decisionmaking in physical MS symptom management. Data sources …

Testing The Efficacy Of Behavioral Nudges For Reducing Plastic Bag Use And Perception Of Levy-Based Policy Among Retail Customers In Bangladesh, Md Tahsin Hasan

Open Access Dissertations

Over the last five decades, plastics have penetrated our lives slowly yet with such certainty that we cannot imagine a day without plastic products. From bottled water to injection syringes, we are submerged in plastics. Plastics have significantly improved human lifestyles and reduced living costs by providing cheap household items. However, it is also evident now that plastics threaten the natural environment and animal and human health. Specifically, single-use plastics are the most ubiquitous nuisance to the environment. Food packaging, pet bottles, and single-use plastic bags are the most found plastic items in household garbage. According to statistics from the …

Associations Between Oyster Consumption And Iron, Zinc, And Cadmium Concentrations In Ghanaian Women, Alyssa Abreu

Open Access Dissertations

Background: Oysters are an excellent source of iron and zinc but may be contaminated by heavy metals such as cadmium. The micronutrient and metal content of smoked, dried oysters as well as the impact of oyster consumption on iron, zinc, and cadmium concentrations in Ghana is unknown.

Objectives: Our objectives were to 1) determine the micronutrient and metal content and health risk of dried, smoked oysters, 2) determine the associations between dietary iron intake with hemoglobin or ferritin concentrations and anemia, 3) determine the associations between oyster consumption and iron, zinc and cadmium concentrations in Ghanaian women living near the …

Understanding The Impact Of Hydroclimatic Variables In Forecasting Geospatial Diarrheal Disease Risk, Farah Nusrat

Open Access Dissertations

Over 2 billion people globally are living in water-stressed regions. With population increase, poor management of natural resources, and a changing climate, water scarcity has become a widespread phenomenon in today’s world. As a result, waterborne diseases remain a major global health problem due to a lack of safe water supply and sanitation facilities. A large part of the global population is still at risk of having waterborne and water-related diarrheal diseases despite many scientific advancements. Meanwhile, Climate Change is exacerbating waterborne disease patterns and trends, as seen by the large increase in diarrheal cases globally. It is thus imperative …

Cranberry Vine And Its Effects On The Periparturient Ovine And Her Offspring, Delaney Smith

Open Access Dissertations

Gastrointestinal nematodes (GIN) are a major health concern globally, particularly for small ruminant producers. The most deadly of these GIN is an anemia-inducing parasite called Haemonchus contortus. Infections of H. contortus are most severe during what's known as the periparturient period (PPP), which is the last 6 weeks of gestation and first 8 weeks of lactation in maternal animals. Widespread genetic resistance of H. contortus to the traditionally used chemical dewormers have led producers and researchers alike to turn to the plant kingdom for answers. Plant based compounds have been used as bioactive compounds for centuries to cure a …

Underlying Mechanisms Of Ubiquitin Specific Peptidase 2 Isoforms Regulation In Hepatocellular Carcinoma By The Farnesoid X Receptor Signaling Pathway, Winifer M. Ali

Open Access Dissertations

Hepatocellular carcinoma (HCC), or liver cancer, is the sixth most common cancer worldwide, and the third leading cause of cancer-related deaths. In 2023, an estimated 41,210 new HCC cases and 29,380 deaths have been reported in the United States with an overall 5-year relative survival rate of 20.8%. It has been predicted that by 2025, there will be more than one million cases of HCC globally. Unfortunately, there are limited effective treatments and current treatment options available are invasive and burdensome. HCC patients are usually diagnosed at the late stages of liver cancer when the only viable treatment options are …

Children’S Outcomes And Maternal Opioid Exposures During Pregnancy, Shuang Wang

Open Access Dissertations

Opioid use among pregnant women has markedly escalated in the United States in recent decades. Alarmingly, one-fifth of these women fill one or more prescriptions for opioids despite concerns about perinatal safety. Consequently, the prevalence of opioid use disorder (OUD) in pregnancy and adverse outcomes in offspring has increased in parallel. In this dissertation, we explored the potential mediating roles of adverse pregnancy and birth outcomes residing in pathways between prenatal opioid exposure and neurodevelopmental disorders (NDDs) in children. Additionally, we assessed the potential synergistic effect of opioid and antidepressant use in pregnancy on NDDs in offspring and the potential …

Biophysical Characterization Of Phlip And Phlip-Cargo Conjugates Developed For Imaging And Therapy, Hannah Visca

Open Access Dissertations

Acidity is considered an alternative biomarker for targeting diseased tissues, such as in the acute phase of inflammation or tumors with poor prognosis. The family of pH Low Insertion Peptides (pHLIPs) are known markers of tissue acidity which provide a useful method for the diagnosis and/or treatment of disease by extracellular or intracellular delivery of imaging agents or therapeutic molecules. In my research, I employ fluorescence and CD spectroscopic techniques to understand how pHLIP's pH-dependent interactions with and insertion into the lipid bilayer of the cell membrane are affected by its sequence and conjugation with cargo and how this correlates …

Diagnostic Brains, Experiential Minds And Metamodernism: Mcewan, Self, And Mccarthy As Case Studies, Mohamed Anis Ferchichi

Open Access Dissertations

In the wake of critical stances encompassing both modernism and postmodernism, we witness a theoretical preoccupation with how recent literary innovations position today's British fiction within the legacy of the novel form. On the one hand, postmodernism disrupted modernism's experiential phenomenology of interiority, subject, and character (what I call an experiential inflexion in critical comprehension of the form). On the other hand, what was declared "the decade of the brain" shifted some narrativization to exteriority, syndromic specifics, and reductive somaticism (what I see as a diagnostic inflexion in critical comprehension of the form). In considering today's British fiction within the …

Elucidating The Mechanisms Of Stress Tolerance In Reef-Building Coral Holobionts, Emma Strand

Open Access Dissertations

Coral reefs worldwide are threatened by climate change effects like increasing ocean warming and ocean acidification. These increased pressures cause a dysbiosis between the coral host, algal endosymbionts, and associated coral microbiome that results in the coral host expelling algal endosymbionts, leaving the coral host with a stark white ‘bleached’ appearance. Without their endosymbionts, coral hosts are forced to sustain themselves energetically with heterotrophy instead of relying on the autotrophic carbon and energy sources that once came from the algal endosymbionts. When this response, termed ‘coral bleaching’, happens reef-wide during an extreme wave of increased ocean temperatures, this is called …

Development Of Localized Drug Delivery Strategies For The Treatment Of Cancers And Infectious Diseases, Weizhou Yue

Open Access Dissertations

Difficult-to-treat human diseases and disorders such as brain cancer and posterior segment eye diseases greatly threaten human health and quality of life. However, the presence of physiological barriers such as the blood-brain barrier (BBB), cornea, and the blood-retinal barrier, renders these organs highly impervious to most therapeutics. As a result, most therapeutics administered systemically have low therapeutic efficacy even with high doses and are often associated with systemic side effects and/or toxicity. Localized drug delivery strategies such as injectables/implants, or locally-acting dosage forms, can circumvent physiological barriers and directly introduce therapeutics to the site of action to improve bioavailability, and …