Digital Commons Network^™

Radiation-Induced Senescence: Therapeutic Opportunities, Jae Ho Kim, Stephen L. Brown, Marcia N. Gordon

Radiation Oncology Articles

The limitation of cancer radiotherapy does not derive from an inability to ablate tumor, but rather to do so without excessively damaging critical tissues and organs and adversely affecting patient's quality of life. Although cellular senescence is a normal consequence of aging, there is increasing evidence showing that the radiation-induced senescence in both tumor and adjacent normal tissues contributes to tumor recurrence, metastasis, and resistance to therapy, while chronic senescent cells in the normal tissue and organ are a source of many late damaging effects. In this review, we discuss how to identify cellular senescence using various bio-markers and the …

Racial Differences In Perceived Risk And Sunscreen Usage, Rebecca Fliorent, Alicia Podwojniak, Lianne Adolphe, Katharine Milani

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Background Although White individuals have higher incidence of melanoma, clinical outcomes are worse among patients with skin of color. This disparity arises from delayed diagnoses and treatment that are largely due to clinical and sociodemographic factors. Investigating this discrepancy is crucial to decrease melanoma-related mortality rates in minority communities. A survey was used to investigate the presence of racial disparities in perceived sun exposure risks and behaviors. Methods A survey consisting of 16 questions was deployed via social media to assess skin health knowledge. Over 350 responses were recorded, and the extracted data were analyzed using statistical software. Results Of …

The View From Ventress - 2021-22 Academic Year, University Of Mississippi, College Of Liberal Arts

Liberal Arts Newsletters

News from the College of Liberal Arts

Resurrecting Olympus, Jordan Ashley Miller

Masters Theses

The objective of this creative project was to reintroduce Greek mythology to the public, adapting the ancient tales to appeal to an ever-evolving world. In order to do the myths justice, it was important to examine adaptations and interpretations over the centuries to determine the philosophical trajectory of mythology. My studies unearthed a diverse portfolio of academic perspectives ranging from the likes of the more formal philosopher Thomas Bullfinch of the 1900s, to the modern, comedy-infused commentator Stephen Fry. Each voice revealed something new to consider. Synthesizing these varying positions into a holistic narrative, I set out to pen a …

The Fire Behind My Passion: Thief's Fire, Jessica Lacey Hackett

Masters Theses

Every day, I am bombarded by vulgarity of every kind through the people around me, the television, music, and sadly literature as well. The fantasy genre is a genre that is filled with made-up worlds and creatures that come from the awe-inspiring human imagination. However, it is not untouched by the vulgarity of this world. Fantasy novels have become just as filled with foul language and sex as the so-called “trashy romance” novels have in them. What is most disturbing about all this is that the vulgarity has leaked into the fantasy novels made for teens. I aim to create …

The Psychological Impact Of Disaster Relief Work On Disaster Relief Volunteers In North America, Zachary Daniel Richard Williams

Doctoral Dissertations and Projects

This study investigated the psychological effects that disaster relief work has on disaster relief volunteers in North America. It provided the necessary framework for research that was conducted to examine if disaster relief volunteers are more vulnerable to developing posttraumatic stress disorder (PTSD) after they volunteer in disaster relief or if they become more resilient and develop posttraumatic growth (PTG) instead. This quantitative study also provided research questions and hypotheses and is a road map for future research. Disaster relief volunteers provide many irreplaceable services to the field of disaster relief. Understanding how disaster relief volunteers are impacted by the …

Impact Of School Closures And Virtual Instruction On Sixth Grade Reading And Math Achievement Of Student Subgroups, Crystal Michelle Pope

Doctoral Dissertations and Projects

The purpose of this quantitative, causal-comparative design study was to determine whether differences existed between the reading and math achievement of sixth grade general education students and students with disabilities who have been identified with a specific learning disability or other health impairment. This study was important because achievement gaps exist between subgroups of students (Farkas et al., 2020). The sample included scores from 144 students in a school division in Southeastern Virginia. The instrument used was the Grade 6 Reading and Math Standards of Learning assessments administered in the spring of 2021. Two one-way ANOVAs were used to compare …

Yoga And Mindfulness For Social-Emotional Development And Resilience In 3–5 Year-Old Children: Non-Randomized, Controlled Intervention, Alessandra N. Bazzano, Yaoyao Sun, Yuanhao Zu, Julia M. Fleckman, Emma A. Blackson, Tejal Patel, Angie Shorty-Belisle, Keith H. Liederman, Cody Roi

School of Medicine Faculty Publications

Background: Early childhood is the key life course period for development of social-emotional skills, providing the foundation for school readiness and resilience in later life. Age-appropriate yoga and mindfulness programs may contribute to the development of critical skills in children. Young children from minoritized communities that face structural racism and health disparities may benefit from programs that support social-emotional development and contribute to future academic success. Systematic reviews of yoga interventions for young children have indicated the potential for effectiveness in supporting social-emotional development, executive function, and physical activity. However, studies of yoga and mindfulness with non-White children are sparse …

Change And Stasis Of Distinct Sediment Microbiomes Across Port Everglades Inlet (Pei) And The Adjacent Coral Reefs, Lauren E. Krausfeldt, Jose V. Lopez, Catherine Bilodeau, Hyo Won Lee, Shelby L. Casali

Biology Faculty Articles

Deep water ports are human built coastal structures that by definition welcome ship traffic and disturbance. Evidence is accumulating that enhanced port activities such as dredging or deepening have negatively affected nearby natural habitats. Port Everglades Inlet (PEI) is a large active South Florida cargo port for over two million people and lies adjacent to coral reefs, dwindling mangroves, and recreational beaches. In this study, the microbial communities of PEI and adjacent reef sediments were characterized to serve as indicators for change due to dredging and assess anthropogenic influence on these sensitive ecosystems by sequencing the V4 region of 16S …

Closed-Loop Modeling Of Central And Intrinsic Cardiac Nervous System Circuits Underlying Cardiovascular Control, Michelle M. Gee, Abraham M. Lenhoff, James S. Schwaber, Babatunde A. Ogunnaike, Rajanikanth Vadigepalli

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

The baroreflex is a multi-input, multi-output physiological control system that regulates blood pressure by modulating nerve activity between the brainstem and the heart. Existing computational models of the baroreflex do not explicitly incorporate the intrinsic cardiac nervous system (ICN), which mediates central control of heart function. We developed a computational model of closed-loop cardiovascular control by integrating a network representation of the ICN within central control reflex circuits. We examined central and local contributions to the control of heart rate, ventricular functions, and respiratory sinus arrhythmia (RSA). Our simulations match the experimentally observed relationship between RSA and lung tidal volume. …

Oregon State Rank Assessment For Pacific Brook Lamprey (Lampetra Pacifica), Eleanor P. Gaines

Institute for Natural Resources Publications

Oregon state conservation status assessment for Pacific Brook Lamprey (Lampetra pacifica) using NatureServe methodology, 2023.

Persistent Fdg Uptake At Apical Aneurysm In A Patient With Cardiac Sarcoidosis, Chaitanya Rojulpote, Shivaraj Patil, Mahesh K. Vidula, Robert Kotloff, Stuart Prenner, Paco E. Bravo

Einstein Health Papers

We present a case of cardiac sarcoidosis with persistent, focal fluorodeoxyglucose uptake at the left ventricular apical aneurysm concerning for ongoing active inflammatory injury, prompting aggressive immunosuppressive therapy. This case highlights the importance of understanding the various clinical entities that may resemble disease activity on fluorodeoxyglucose positron emission tomography/computed tomography imaging. (Level of Difficulty: Intermediate.)

Environmental Enrichment Factors Associated With The Activity Level Of Bottlenose Dolphins Under Professional Care, Lisa K. Lauderdale, K. Alex Shorter, Joaquin Gabaldon, Jill D. Mellen, Multiple Additional Authors

Biology Faculty Publications and Presentations

Environmental enrichment can be used to improve the welfare of dolphins in zoos and aquariums. Bottlenose dolphins under professional care are typically provided with a range of enrichment that has a variety of features and levels of complexity at various frequencies. In the present study, a subset of data from a larger study entitled “Towards understanding the welfare of cetaceans in zoos and aquariums” (colloquially called the Cetacean Welfare Study) was used to examine the relationship between activity level and enrichment buoyancy as well as enrichment provisioning schedules. Survey data were collected from accredited zoos and aquariums related to the …

Excessive Mechanotransduction In Sensory Neurons Causes Joint Contractures, Shang Ma, Adrienne E Dubin, Luis O Romero, Meaghan Loud, Alexandra Salazar, Sarah Chu, Nikola Klier, Sameer Masri, Yunxiao Zhang, Yu Wang, Alex T Chesler, Katherine A Wilkinson, Valeria Vásquez, Kara L Marshall, Ardem Patapoutian

Faculty, Staff and Student Publications

Distal arthrogryposis (DA) is a collection of rare disorders that are characterized by congenital joint contractures. Most DA mutations are in muscle- and joint-related genes, and the anatomical defects originate cell-autonomously within the musculoskeletal system. However, gain-of-function mutations in PIEZO2, a principal mechanosensor in somatosensation, cause DA subtype 5 (DA5) through unknown mechanisms. We show that expression of a gain-of-function PIEZO2 mutation in proprioceptive sensory neurons that mainly innervate muscle spindles and tendons is sufficient to induce DA5-like phenotypes in mice. Overactive PIEZO2 causes anatomical defects through increased activity within the peripheral nervous system during postnatal development. Furthermore, botulinum toxin …

Journey Through The In-Between: A Haibun Anthology, Jonathan Andrew Painter

Masters Theses

The critical paper addresses the haiku and haibun of the seventeenth-century Japanese poet Matsuo Basho and argues that his poetry demonstrated a high level of ingenuity and flexibility. Accordingly, it serves as a model that can be reappropriated by modern poets writing in a different language and context at a distance of hundreds of years. The haibun anthology entitled "Journey Through the In-Between" is divided into two main parts. Part One presents the ambiguity that I have discovered on my mental and spiritual journey of faith. It is divided into five chapters. Each chapter’s title and content features two juxtaposed …

Why So Serious? Using The Belongingness Need Tenet From The Self-Determination Theory To Examine Workplace Humor And Its Outcomes, Katharine Lucille Mcmahon

Dissertations and Theses

The small body of literature for workplace humor remains fragmented due to the lack of coherence in conceptualization and theory. Furthermore, the distinction between positive and negative humor adds complexity to predicting the outcomes of humor. Focusing on the foundation aspect of humor as a form of social play provides guidance on choosing a theory-informed integrative framework that could explain the implications of humor in the workplace. The belongingness need tenet of the self-determination theory offers a promising framework to synthesize existing research and to direct future studies. Paper 1 reviews the literature and concludes with an integrative framework suggesting …

A Model For The Development Of A Popular Music Listening Curriculum, Micki Michele Berlin

Doctoral Dissertations and Projects

Secondary schools in Texas typically only offer performance-based ensembles to students as their music options. These classes require public performances, extracurricular time commitments, and financial obligations. Because of these and other issues, many students select non-music classes to fulfill their fine arts graduation requirements. Although it can be passive in nature, listening is how most people interact with music. Unfortunately, listening-based curricula are rarely available to secondary students. Where music appreciation classes are offered, the music studied is often outdated and unfamiliar to students. This qualitative study identified the pedagogical components present in an existing classical music listening curricula. These …

Renewing Historical Criminology: Scope, Significance, And Future Directions, Iain Channing, David Churchill, Henry Yeomans

School of Law, Humanities and Social Sciences

Recent years have seen increasing interest in, and scholarly discussion of, historical criminology. Yet there remains at present no clear, settled view as to what historical criminology entails, how it is best pursued, and what its future might hold. This article explores the several conceptions of historical criminology found in the present literature, which associate it variously with archival research, practical inquiry, a concern with temporality, and a certain approach to interdisciplinary scholarship. Adopting the view that historical criminology entails a special regard for historical time, the review goes on to assess its significance to the wider field, examining its …

Sheep Preference For Fresh Leaf And Stem Of Seven Accessions Of Tedera Was Not Influenced By Prior Grazing Experience And Wilting Made No Difference, Justin Hardy, Chris Oldham, Phil Vercoe, Dean Thomas, John Milton, Daniel Real, Andrew Van Burgel, Eric Dobbe

Grain and Other Field Crops Research Articles

Tedera is a valuable high-quality forage for sheep during summer–autumn. There is evidence that prior grazing experience of novel forages influences preference and haymaking of tedera improves preference by goats. In the first experiment, it was hypothesised that the voluntary feed intake (VFI) of fresh leaves and stems of tedera by sheep would be greater for experienced vs. naïve sheep. In the second experiment, it was hypothesised that the VFI of naïve sheep fed wilted leaves and stems of tedera would be greater than fresh leaves and stems of tedera. To test these hypotheses, adult Merino sheep were fed seven …

Expansion And Mechanistic Insights Into De Novo Deaf1 Variants In Deaf1-Associated Neurodevelopmental Disorders, Stacey R Mcgee, Shivakumar Rajamanickam, Sandeep Adhikari, Oluwatosin C Falayi, Theresa A Wilson, Brian J Shayota, Jessica A Cooley Coleman, Cindy Skinner, Raymond C Caylor, Roger E Stevenson, Caio Robledo D' Angioli Costa Quaio, Berenice Cunha Wilke, Jennifer M Bain, Kwame Anyane-Yeboa, Kaitlyn Brown, John M Greally, Emilia K Bijlsma, Claudia A L Ruivenkamp, Keren Politi, Lydia A Arbogast, Michael W Collard, Jodi I Huggenvik, Sarah H Elsea, Philip J Jensik

Faculty, Staff and Students Publications

De novo deleterious and heritable biallelic mutations in the DNA binding domain (DBD) of the transcription factor deformed epidermal autoregulatory factor 1 (DEAF1) result in a phenotypic spectrum of disorders termed DEAF1-associated neurodevelopmental disorders (DAND). RNA-sequencing using hippocampal RNA from mice with conditional deletion of Deaf1 in the central nervous system indicate that loss of Deaf1 activity results in the altered expression of genes involved in neuronal function, dendritic spine maintenance, development, and activity, with reduced dendritic spines in hippocampal regions. Since DEAF1 is not a dosage-sensitive gene, we assessed the dominant negative activity of previously identified de novo variants …

The Indiana Statesman, January 12, 2023, Indiana State University

Student Newspaper

Sycamores bring in the 2023 year; New LAPD policy lowers off-duty drinking limit; ISU makes steps towards further inclusivity; ISU hosts retirement celebration for Carole Brassie

Insights From The Management Of Offshore Energy Resources: Toward An Ecosystem-Services Based Management Approach For Deep-Ocean Industries, M. Emilia Bravo, Miriam I. Brandt, Jesse M. A. Van Der Grient, Thomas G. Dahlgren, Patricia Esquete, Sabine Gollner, Daniel O. B. Jones, Lisa A. Levin, Craig R. Mcclain, Bhavani E. Narayanaswamy, Tracey Sutton, Lissette Victorero, Erik E. Cordes

Marine & Environmental Sciences Faculty Articles

The deep ocean comprises complex ecosystems made up of numerous community and habitat types that provide multiple services that benefit humans. As the industrialization of the deep sea proceeds, a standardized and robust set of methods and metrics need to be developed to monitor the baseline conditions and any anthropogenic and climate change-related impacts on biodiversity, ecosystem function, and ecosystem services. Here, we review what we have learned from studies involving offshore-energy industries, including state-of-the-art technologies and strategies for obtaining reliable metrics of deep-sea biodiversity and ecosystem function. An approach that includes the detection and monitoring of ecosystem services, with …

Strengthening A One Health Approach To Emerging Zoonoses, Samira Mubareka, John Amuasi, Arinjay Banerjee, Hélène Carabin, Joe Copper Jack, Claire Jardine, Bogdan Jaroszewicz, Greg Keefe, Jonathon Kotwa, Susan Kutz, Deborah Mcgregor, Anne Mease, Lily Nicholson, Katarzyna Nowak, Brad Pickering, Maureen Reed, Johanne Saint-Charles, Katarzyna Simonienko, Trevor Smith, J. Scott Weese, E. Jane Parmley

Articles & Book Chapters

Given the enormous global impact of the COVID-19 pandemic, outbreaks of highly pathogenic avian influenza in Canada, and manifold other zoonotic pathogen activity, there is a pressing need for a deeper understanding of the human-animal-environment interface and the intersecting biological, ecological, and societal factors contributing to the emergence, spread, and impact of zoonotic diseases. We aim to apply a One Health approach to pressing issues related to emerging zoonoses, and propose a functional framework of interconnected but distinct groups of recommendations around strategy and governance, technical leadership (operations), equity, education and research for a One Health approach and Action Plan …

Effect Of A Plant-Based Vs Omnivorous Soul Food Diet On Weight And Lipid Levels Among African American Adults: A Randomized Clinical Trial, Gabrielle M. Turner-Mcgrievy Ph.D., Rd, Sara Wilcox Phd, Edward A. Frongillo Jr. Ph.D., E. Angela Murphy, Brent Hutto Msph, Mary Wilson Phd, Mph, Marty Davey, John A. Bernhart Ph.D., Mph, Ches, Nkechi Okpara, Shiba Bailey, Emily Hu

Faculty Publications

Importance: More African American individuals die from cardiovascular disease (CVD) than any other chronic disease condition. Despite this disparity, African American individuals are underrepresented in nutrition and CVD interventions. Objective: To compare the effects of an entirely plant-based (vegan) or low-fat omnivorous (omni) diet on change in body weight and lipids during a 2-year intervention. Design, Setting, and Participants: The Nutritious Eating With Soul (NEW Soul) study was a 2-year, randomized clinical trial conducted in 2 cohorts (2018-2020 and 2019-2021) that took place in a university teaching kitchen in Columbia, South Carolina (before March 2020), and via online videoconference sessions …

Microrna-Mrna Networks Are Dysregulated In Opioid Use Disorder Postmortem Brain: Further Evidence For Opioid-Induced Neurovascular Alterations, Sandra L Grimm, Emily F Mendez, Laura Stertz, Thomas D Meyer, Gabriel R Fries, Tanmay Gandhi, Rupa Kanchi, Sudhakar Selvaraj, Antonio L Teixeira, Thomas R Kosten, Preethi Gunaratne, Cristian Coarfa, Consuelo Walss-Bass

Faculty, Staff and Student Publications

INTRODUCTION: To understand mechanisms and identify potential targets for intervention in the current crisis of opioid use disorder (OUD), postmortem brains represent an under-utilized resource. To refine previously reported gene signatures of neurobiological alterations in OUD from the dorsolateral prefrontal cortex (Brodmann Area 9, BA9), we explored the role of microRNAs (miRNA) as powerful epigenetic regulators of gene function.

METHODS: Building on the growing appreciation that miRNAs can cross the blood-brain barrier, we carried out miRNA profiling in same-subject postmortem samples from BA9 and blood tissues.

RESULTS: miRNA-mRNA network analysis showed that even though miRNAs identified in BA9 and blood …

Fda Greenlights Lab-Grown Meat For Human Consumption, John Rose

D.U.Quark

No abstract provided.

Oxphos Defects Cause Hypermetabolism And Reduce Lifespan In Cells And In Patients With Mitochondrial Diseases, Gabriel Sturm, Kalpita R Karan, Anna S Monzel, Balaji Santhanam, Tanja Taivassalo, Céline Bris, Sarah A Ware, Marissa Cross, Atif Towheed, Albert Higgins-Chen, Meagan J Mcmanus, Andres Cardenas, Jue Lin, Elissa S Epel, Shamima Rahman, John Vissing, Bruno Grassi, Morgan Levine, Steve Horvath, Ronald G Haller, Guy Lenaers, Douglas C Wallace, Marie-Pierre St-Onge, Saeed Tavazoie, Vincent Procaccio, Brett A Kaufman, Erin L. Seifert, Michio Hirano, Martin Picard

Department of Pediatrics Faculty Papers

Patients with primary mitochondrial oxidative phosphorylation (OxPhos) defects present with fatigue and multi-system disorders, are often lean, and die prematurely, but the mechanistic basis for this clinical picture remains unclear. By integrating data from 17 cohorts of patients with mitochondrial diseases (n = 690) we find evidence that these disorders increase resting energy expenditure, a state termed hypermetabolism. We examine this phenomenon longitudinally in patient-derived fibroblasts from multiple donors. Genetically or pharmacologically disrupting OxPhos approximately doubles cellular energy expenditure. This cell-autonomous state of hypermetabolism occurs despite near-normal OxPhos coupling efficiency, excluding uncoupling as a general mechanism. Instead, hypermetabolism is associated …

Type Ii Taste Cells Participate In Mucosal Immune Surveillance, Yumei Qin, Salin Raj Palayyan, Xin Zheng, Shiyi Tian, Robert F. Margolskee, Sunil Kumar Sukumaran

Department of Nutrition and Health Sciences: Faculty Publications

The oral microbiome is second only to its intestinal counterpart in diversity and abundance but its effects on taste cells remains largely unexplored. Using single-cell RNASeq, we found that mouse taste cells, in particular, sweet and umami receptor cells that express taste 1 receptor member 3 (Tas1r3), have a gene expression signature reminiscent of Microfold (M) cells, a central player in immune surveillance in the mucosa-associated lymphoid tissue (MALT) such as those in the Peyer’s patch and tonsils. Administration of tumor necrosis factor ligand superfamily member 11 (TNFSF11; also known as RANKL), a growth factor required for differentiation …

Contagious Animality: Species, Disease, And Metaphor In Early Modern Literature And Culture, Jeremy Cornelius

LSU Doctoral Dissertations

In my dissertation, Contagious Animality: Species, Disease, and Metaphor in Early Modern Literature and Culture, I close read examples of Renaissance drama alongside their contemporary cultural texts to examine anxieties around social differences as constructed and mediated through what I call “contagious animality” in early modern English culture. Animal metaphors circulated anxieties around social differences on the early modern cultural stage in English drama where animality elicits uncertainties about identitarian constructions of difference. In this vein, I close read formal elements and their interactions with early modern culture to argue that animal metaphors transmit modes of speciating difference in …

Visual Analytics And Modeling Of Materials Property Data, Diwas Bhattarai

LSU Doctoral Dissertations

Due to significant advancements in experimental and computational techniques, materials data are abundant. To facilitate data-driven research, it calls for a system for managing and sharing data and supporting a set of tools for effective data analysis and modeling. Generally, a given material property M can be considered as a multivariate data problem. The dimensions of M are the values of the property itself, the conditions (pressure P, temperature T, and multi-component composition X) that control the concerned property, and relevant metadata I (source, date).

Here we present a comprehensive database considering both experimental and computational sources …