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2023

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Toxicology Of Nuclear Polyhedrosis Virus, Botanical And Synthetic Pesticides On Mortality Rate Of Crocidolomia Binotalis (Zeller), Bakhroini Habriantono, Suharto Suharto, Wagiyana Wagiyana, Mohammad Hoesain, Mochammad Wildan Jatmiko, Sigit Prastowo, Ankardiansyah Pandu Pradana, Anggi Anwar Hendra Nurdika, Fariz Kustiawan Alfarisy Feb 2023

Toxicology Of Nuclear Polyhedrosis Virus, Botanical And Synthetic Pesticides On Mortality Rate Of Crocidolomia Binotalis (Zeller), Bakhroini Habriantono, Suharto Suharto, Wagiyana Wagiyana, Mohammad Hoesain, Mochammad Wildan Jatmiko, Sigit Prastowo, Ankardiansyah Pandu Pradana, Anggi Anwar Hendra Nurdika, Fariz Kustiawan Alfarisy

Baghdad Science Journal

Crocidolomia binotalis (Cb) (Zeller) is one of the main pests of cabbage which is difficult for farmers to control in the Ijen Crater in Indonesia. The demand for cabbage in Indonesia is increasing every year, so intensification efforts are continuously being made. Farmers intensively use synthetic pesticides as the primary control of Cb. The purpose of this study is to examine several control agents that can be used as an alternative to synthetic pesticides. Then, it provides recommendations to Ijen Crater farmers to adapt in reducing the use of synthetic pesticides. The biopesticide used was based on the Nuclear Polyhedrosis …


Sediment Assessment Of Al-Hindyia And Al-Abbasyia River / Iraq By Aquatic Oligocheata Community As Bioindicators, Nadia Imad Al-Ameen, Dlovan Kammal Al-Jaff Feb 2023

Sediment Assessment Of Al-Hindyia And Al-Abbasyia River / Iraq By Aquatic Oligocheata Community As Bioindicators, Nadia Imad Al-Ameen, Dlovan Kammal Al-Jaff

Baghdad Science Journal

Bioindicators have an important role in assessing the quality of water bodies. Aquatic oligocheates, was used as a bioindicator to assess the sediment quality of Al-Hindyia and AL-Abbasyia river (branches of Euphrates River in Iraq). Two sites in each river have been chosen for this purpose, site S1 was located at Al-Hindyia River and S2 at Al-Abbasyia River. Some kinds of biological indices were used in this study, comprising the percentage of oligochaetes in benthic invertebrates, ranged from 20.3-60.16%. While the percentage of Tubificidae within benthic invertebrates was close 43.3-43.9%.Index of pollution D ranged from 0.13-0.21. The maximum percentage of …


Spectrophotometric Method Combined With Hplc For Bisphenol F Determination In Plastic Bottled Water And Thermal Paper, Narjes Mohanad Habib, Maha Al-Tameemi, Mohanad Lateef Tofah, Nahlah Kadhim Salman, Hawraa Mahmood Abdulkareem Feb 2023

Spectrophotometric Method Combined With Hplc For Bisphenol F Determination In Plastic Bottled Water And Thermal Paper, Narjes Mohanad Habib, Maha Al-Tameemi, Mohanad Lateef Tofah, Nahlah Kadhim Salman, Hawraa Mahmood Abdulkareem

Baghdad Science Journal

Based on the diazotization-coupling reaction, a new, simple, and sensitive spectrophotometric method for determining of a trace amount of (BPF) is presented in this paper. Diazotized metoclopramide reagent react with bisphenol F produces an orange azo-compound with a maximum absorbance at 461 nm in alkaline solution. The experimental parameters were optimized such as type of alkaline medium, concentration of NaOH, diazotized metoclopramide amount, order additions, reaction time, temperature, and effect of organic solvents to achieve the optimal performance for the proposed method. The absorbance increased linearly with increasing bisphenol F concentration in the range of 0.5-10 μg mL-1 under ideal …


Accumulation Of Heavy Metals In Agricultural Crops And Ecological Series Of Crops Placement, Zafar Zairovich Uzakov, Khusniddin Nagimovich Karimov, Zair Uzakovich Uzakov, Ravshan Abdurazakovich Eshonkulov Feb 2023

Accumulation Of Heavy Metals In Agricultural Crops And Ecological Series Of Crops Placement, Zafar Zairovich Uzakov, Khusniddin Nagimovich Karimov, Zair Uzakovich Uzakov, Ravshan Abdurazakovich Eshonkulov

Baghdad Science Journal

The accumulation of toxic elements in vegetables and melons grown in agriculture, Brassica rapa - turnip, Solanum lycopersicum - tomato, Citrullus lanatus - watermelon, Capsicum annuum - bell pepper, Daucus carota - carrots, Cucurbita pepo - pumpkin, Cucumis melo - melon, and also Prunus armeniaca - apricot from fruit trees were analyzed. The excess of maximum allowable concentrations in agricultural crops of the element As by 1.65-1.75, Cd - 1.6-2.3, Cr -1.2-2.35, Cu -1.6-3.3, Ni - 1.16-3.53, Pb - 1.54-3.08, Al - 1.36-3.5, Sb - 2.0-33, Se - 1.1-3.3 times was established. The maximum allowable concentration of mercury in vegetables …


Wild 571.00: Estimation Of Demographic Parameters, Daniel P. Walsh Feb 2023

Wild 571.00: Estimation Of Demographic Parameters, Daniel P. Walsh

University of Montana Course Syllabi, 2021-2025

No abstract provided.


Mart 232.50: Interactive Web Ii, Cheryl M. Galipeau Feb 2023

Mart 232.50: Interactive Web Ii, Cheryl M. Galipeau

University of Montana Course Syllabi, 2021-2025

No abstract provided.


Wild 472.01: Wildlife Handling And Chemical Immobilization For Wildlife Professionals, Mark R. Johnson Feb 2023

Wild 472.01: Wildlife Handling And Chemical Immobilization For Wildlife Professionals, Mark R. Johnson

University of Montana Course Syllabi, 2021-2025

No abstract provided.


Using An Evolutionary Approach To Improve Predictive Ability In Social Sciences: Property, The Endowment Effect, And Law, Owen D. Jones, Sarah F. Brosnan Feb 2023

Using An Evolutionary Approach To Improve Predictive Ability In Social Sciences: Property, The Endowment Effect, And Law, Owen D. Jones, Sarah F. Brosnan

Vanderbilt Law School Faculty Publications

From the perspective of other disciplines, evolutionary approaches more often provide explanation and coherence than they help to solve discrete problems. We believe that more examples of the latter sort will help both with disciplinary synthesis and with the advance of knowledge. Here we describe a 20-year arc of research to demonstrate the problem-solving utility of an evolutionary perspective by focusing, as a case study, on a particular cognitive bias – the endowment effect – that has implications for law. Legal systems often assume that humans make decisions that are substantively rational, consistent, and aimed at maximizing their own wellbeing. …


Me-Em Enewsbrief, December 2022, Department Of Mechanical Engineering-Engineering Mechanics, Michigan Technological University Feb 2023

Me-Em Enewsbrief, December 2022, Department Of Mechanical Engineering-Engineering Mechanics, Michigan Technological University

Department of Mechanical and Aerospace Engineering eNewsBrief

No abstract provided.


Dengue Fever In South And Southeast Asia, Mikaela D. Lubin Feb 2023

Dengue Fever In South And Southeast Asia, Mikaela D. Lubin

Ballard Brief

Dengue fever is a mosquito-borne illness that impacts South and Southeast Asia at significant rates. It is carried primarily by the aedes aegypti mosquito, a species that thrives in warm, tropical climates. Features of dengue include excruciating pain and, in severe cases, internal bleeding, shock, and death. The spread of dengue in South and Southeast Asia is due to several factors, including advancements in transportation, poor preventative measures, poor sanitation, and subsequent standing water, which is an ideal breeding ground for mosquitoes. Dengue causes many negative consequences on individuals and communities it affects, including pain and suffering, lasting physiological effects, …


Csd 205.01: Clinical Applications And Observations In Speech Language Pathology And Audiology, Kimberly A. Ramsey Feb 2023

Csd 205.01: Clinical Applications And Observations In Speech Language Pathology And Audiology, Kimberly A. Ramsey

University of Montana Course Syllabi, 2021-2025

No abstract provided.


Justice Alito's Laundry List: Highlights From Appendix C Of Bostock And A Roadmap For Lgbtq+ Legal Advocates, Peter Quinn Feb 2023

Justice Alito's Laundry List: Highlights From Appendix C Of Bostock And A Roadmap For Lgbtq+ Legal Advocates, Peter Quinn

William & Mary Law Review

After a brief background on Bostock [v. Clayton County] in Part I, the bulk of this Note seeks to examine Justice Alito’s Bostock dissent and its potential future usefulness for LGBTQ+ advocates. Part II will analyze Justice Alito’s dissent and Appendix C, arguing that his concerns about Bostock’s consequences across other federal statutes fall into three primary categories of usefulness. The remaining Parts will survey these categories, including the “small potatoes” in Part III, the “blockbusters” in Part IV, and the “under-the-radar” areas in Part V. Part V takes particular notice of potential applications of Bostock’s …


Untangling The Additive And Multiplicative Relations Between Natural Scenery Exposure And Human-Animal Interaction On Affective Well-Being: Evidence From Daily Diary Studies, Adalia Yin Hui Goh, Shu Min Chia, Nadyanna M. Majeed, Nicole R.Y. Chen, Andree Hartanto Feb 2023

Untangling The Additive And Multiplicative Relations Between Natural Scenery Exposure And Human-Animal Interaction On Affective Well-Being: Evidence From Daily Diary Studies, Adalia Yin Hui Goh, Shu Min Chia, Nadyanna M. Majeed, Nicole R.Y. Chen, Andree Hartanto

Research Collection School of Social Sciences

Built nature spaces have been increasingly integrated into our urban environments in recent years with the aim of reaping their psychological benefits. However, despite numerous works of research on the relationship between nature exposure and well-being, most studies have looked into the benefits of well-being from the lens of isolated elements of nature, such as natural scenery or animal exposure. This study aims to fill in the gaps by examining the additive and multiplicative relationships between natural scenery exposure and human–animal interaction on affective well-being (i.e., positive affect, negative affect, and stress) through a daily diary study. Over seven days, …


Caesarean Section For Placenta Previa: A Retrospective Cohort Study Of Anaesthesia Techniques, Samina Ismail, Saima Rashid Feb 2023

Caesarean Section For Placenta Previa: A Retrospective Cohort Study Of Anaesthesia Techniques, Samina Ismail, Saima Rashid

Department of Anaesthesia

Objective: Placenta previa is associated with maternal and neonatal morbidity and mortality. This study aims to add to the limited literature from the developing world on the association of different anaesthetic techniques with blood loss, the need for blood transfusion, and maternal/ neonatal outcomes among women undergoing caesarean section with placenta previa.
Methods: This retrospective study was conducted at Aga University Hospital, Karachi, Pakistan. The patient population included parturients undergoing caesarean section for placenta previa from January 1, 2006, through December 31, 2019.
Results: Out of 276 consecutive cases of placenta previa progressing to caesarean section during the study period, …


‘Chinese Virus’: A Critical Discourse Analysis Of Anti-Asian Racist Discourse During The Covid-19 Pandemic, Peiwen Wang, Theresa Catalano Feb 2023

‘Chinese Virus’: A Critical Discourse Analysis Of Anti-Asian Racist Discourse During The Covid-19 Pandemic, Peiwen Wang, Theresa Catalano

Department of Teaching, Learning, and Teacher Education: Faculty Publications

Since the emergence of COVID-19, researchers have documented an increase in cases of anti-Asian racism and hate crimes. Research shows a possible connection between the ‘Chinese virus’ discourse of the Trump administration and violence in society (Arora and Kim 2020:387). Drawing from critical discourse studies we explore 2,071 comments from one YouTube video which documents anti-China rhetoric by the Trump administration in order to understand the underlying strategies commenters relied on in their reproduction and defence of this discourse. Findings show the trickle-down influence of Trump’s discourse on YouTube commenters, but also ways in which social media created a platform …


Investigation Of Functional Performance Of Treatment Systems For Textile Wastewater In Selected Textile Industries In Tanzania, Joshua Akinropo Oyetade, Revocatus Lazaro Machunda, Askwar Hilonga Feb 2023

Investigation Of Functional Performance Of Treatment Systems For Textile Wastewater In Selected Textile Industries In Tanzania, Joshua Akinropo Oyetade, Revocatus Lazaro Machunda, Askwar Hilonga

All Rsif Scholars' Publications

Textile industrialization is an integral part of the economic growth in Tanzania. However, the corresponding wastewater from textile treatment processes consists of dyes and auxiliaries associated with acute toxicological impacts. This necessitates an investigation of the functional performance of the industrial treatment systems used before effluent discharge. The study primarily accesses the catalog of industrial dyes and the functionality of the treatment system at Arusha, Morogoro and Dar es Salaam vis-à-vis the effluent physicochemical properties. The analytical study reveals disperse (42%), vat (34%) and reactive (26%) as the most used industrial dyes. The physicochemical properties of the quantified wastewater reveal …


Impacts Of Covid-19 On Us Agri-Food Supply Chain Businesses: Regional Survey Results, Hikaru Hanawa Peterson, Gigi Digiacomo, Christa D. Court, Michelle Miller, Gustavo Oliveira, Andrew W. Stevens, Li Zhang, Lauri M. Baker, Joseph Nowak, Eyrika Orlando, Bijeta Bijen Saha Feb 2023

Impacts Of Covid-19 On Us Agri-Food Supply Chain Businesses: Regional Survey Results, Hikaru Hanawa Peterson, Gigi Digiacomo, Christa D. Court, Michelle Miller, Gustavo Oliveira, Andrew W. Stevens, Li Zhang, Lauri M. Baker, Joseph Nowak, Eyrika Orlando, Bijeta Bijen Saha

Geography

Visible disruptions of appropriate food distribution for end consumers during the onset of the COVID-19 pandemic prompted calls for an urgent, renewed look at how the U.S. agri-food system is impacted by and responds to pandemics, natural disasters, and human-made crises. Previous studies suggest the COVID-19 pandemic yielded uneven impacts across agri-food supply chain segments and regions. For a rigorously comparable assessment of the impact of COVID-19 on agri-food businesses, a survey was administered from February to April 2021 to five segments of the agri-food supply chain in three study regions (California, Florida, and the two-state region of Minnesota-Wisconsin). Results …


Effects Of A 12-Week Plant-Based Diet Program On Obese And Overweight Adults In Rural Michigan, Nadine Larcher Feb 2023

Effects Of A 12-Week Plant-Based Diet Program On Obese And Overweight Adults In Rural Michigan, Nadine Larcher

Doctor of Nursing Practice Projects

Background

Overweight and obesity among adults are a rising epidemic in the U.S. Obesity is a risk factor for many chronic diseases and impacts morbidity and mortality. Despite our high-tech medical care system in the U.S., we are losing the war on obesity due to not addressing the underlying problems. These include unhealthy lifestyles and an unhealthy diet. A growing body of research studies has shown that adopting a low-fat whole food plant-based diet (WFPBD) regime consisting of whole grains, fruits, vegetables, legumes, and no animal-based products is an effective measure to counteract the rising pandemic of chronic diseases related …


Autophagy Requirements For Eye Lens Differentiation And Transparency, Lisa Brennan, M Joseph Costello, J Fielding Hejtmancik, A. Menko, S Amer Riazuddin, Alan Shiels, Marc Kantorow Feb 2023

Autophagy Requirements For Eye Lens Differentiation And Transparency, Lisa Brennan, M Joseph Costello, J Fielding Hejtmancik, A. Menko, S Amer Riazuddin, Alan Shiels, Marc Kantorow

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Recent evidence points to autophagy as an essential cellular requirement for achieving the mature structure, homeostasis, and transparency of the lens. Collective evidence from multiple laboratories using chick, mouse, primate, and human model systems provides evidence that classic autophagy structures, ranging from double-membrane autophagosomes to single-membrane autolysosomes, are found throughout the lens in both undifferentiated lens epithelial cells and maturing lens fiber cells. Recently, key autophagy signaling pathways have been identified to initiate critical steps in the lens differentiation program, including the elimination of organelles to form the core lens organelle-free zone. Other recent studies using ex vivo lens culture …


Bmkt 325.03: Principles Of Marketing, Samuel D. Spector Feb 2023

Bmkt 325.03: Principles Of Marketing, Samuel D. Spector

University of Montana Course Syllabi, 2021-2025

No abstract provided.


Bmkt 325.02: Principles Of Marketing, Samuel D. Spector Feb 2023

Bmkt 325.02: Principles Of Marketing, Samuel D. Spector

University of Montana Course Syllabi, 2021-2025

No abstract provided.


Stop Trashing The Planet: Addressing Global Warming And Climate Change From The Perspective Of Food Waste Reduction, Dorothy Chen Feb 2023

Stop Trashing The Planet: Addressing Global Warming And Climate Change From The Perspective Of Food Waste Reduction, Dorothy Chen

North Carolina Journal of International Law

No abstract provided.


Wildfire Risk Zone Mapping In Contrasting Climatic Conditions: An Approach Employing Ahp And F-Ahp Models, Aishwarya Sinha, Suresh Nikhil, Rajendran Shobha Ajin, Jean Homian Danumah, Sunil Saha, Romulus Costache, Ambujendran Rajaneesh, Kochappi Sathyan Sajinkumar, Kolangad Amrutha, Alfred Johny, Fahad Marzook, Pratheesh Chacko Mammen, Kamal Abdelrahman, Mohammed S. Fnais, Mohamed Abioui Feb 2023

Wildfire Risk Zone Mapping In Contrasting Climatic Conditions: An Approach Employing Ahp And F-Ahp Models, Aishwarya Sinha, Suresh Nikhil, Rajendran Shobha Ajin, Jean Homian Danumah, Sunil Saha, Romulus Costache, Ambujendran Rajaneesh, Kochappi Sathyan Sajinkumar, Kolangad Amrutha, Alfred Johny, Fahad Marzook, Pratheesh Chacko Mammen, Kamal Abdelrahman, Mohammed S. Fnais, Mohamed Abioui

Michigan Tech Publications, Part 1

Wildfires are one of the gravest and most momentous hazards affecting rich forest biomes worldwide; India is one of the hotspots due to its diverse forest types and human-induced reasons. This research aims to identify wildfire risk zones in two contrasting climate zones, the Wayanad Wildlife Sanctuary in the Western Ghats and the Kedarnath Wildlife Sanctuary in the Himalayas, using geospatial tools, analytical hierarchy process (AHP), and fuzzy-AHP models to assess the impacts of various conditioning factors and compare the efficacy of the two models. Both of the wildlife sanctuaries were severely battered by fires in the past, with more …


Regulation Of Skeletal Muscle Protein Synthesis In The Preterm Pig By Intermittent Leucine Pulses During Continuous Parenteral Feeding, Shaji K Chacko, Caitlin Vonderohe, Barbara Stoll, Douglas G Burrin, Marta L Fiorotto, Teresa A Davis Feb 2023

Regulation Of Skeletal Muscle Protein Synthesis In The Preterm Pig By Intermittent Leucine Pulses During Continuous Parenteral Feeding, Shaji K Chacko, Caitlin Vonderohe, Barbara Stoll, Douglas G Burrin, Marta L Fiorotto, Teresa A Davis

Faculty, Staff and Students Publications

BACKGROUND: Extrauterine growth restriction is a common complication of preterm birth. Leucine (Leu) is an agonist for the mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) signaling pathway that regulates translation initiation and protein synthesis in skeletal muscle. Previously, we showed that intermittent intravenous pulses of Leu to neonatal pigs born at term receiving continuous enteral nutrition increases muscle protein synthesis and lean mass accretion. Our objective was to determine the impact of intermittent intravenous pulses of Leu on muscle protein anabolism in preterm neonatal pigs administered continuous parenteral nutrition.

METHODS: Following preterm delivery (on day 105 of 115 gestation), …


The Roles Of Cyp1a2 And Cyp2d In Pharmacokinetic Profiles Of Serotonin And Norepinephrine Reuptake Inhibitor Duloxetine And Its Metabolites In Mice, Kevin R Mackenzie, Shelton R Boyd, Mercedes Barzi, Karl-Dimiter Bissig, Damian W Young, Feng Li Feb 2023

The Roles Of Cyp1a2 And Cyp2d In Pharmacokinetic Profiles Of Serotonin And Norepinephrine Reuptake Inhibitor Duloxetine And Its Metabolites In Mice, Kevin R Mackenzie, Shelton R Boyd, Mercedes Barzi, Karl-Dimiter Bissig, Damian W Young, Feng Li

Faculty, Staff and Students Publications

Duloxetine (DLX) is widely used to treat major depressive disorder. Little is known about the mechanistic basis for DLX-related adverse effects (e.g., liver injury). Human CYP1A2 and CYP2D6 mainly contributes to DLX metabolism, which was proposed to be involved in its adverse effects. Here, we investigated the roles of Cyp1a2 and Cyp2d on DLX pharmacokinetic profile and tissue distribution using a Cyp1a2 knockout (Cyp1a2-KO) mouse model together with a Cyp2d inhibitor (propranolol). Cyp1a2-KO has the few effects on the systematic exposure (area under the plasma concentration-time curve, AUC) and tissue disposition of DLX and its primary metabolites. Propranolol dramatically increased …


Steering Particles Via Micro-Actuation Of Chemical Gradients Using Model Predictive Control, Mark N. Mcdonald, Cameron K. Peterson, Douglas R. Tree Feb 2023

Steering Particles Via Micro-Actuation Of Chemical Gradients Using Model Predictive Control, Mark N. Mcdonald, Cameron K. Peterson, Douglas R. Tree

Faculty Publications

Biological systems rely on chemical gradients to direct motion through both chemotaxis and signaling, but synthetic approaches for doing the same are still relatively naïve. Consequently, we present a novel method for using chemical gradients to manipulate the position and velocity of colloidal particles in a microfluidic device. Specifically, we show that a set of spatially localized chemical reactions that are sufficiently controllable can be used to steer colloidal particles via diffusiophoresis along an arbitrary trajectory. To accomplish this, we develop a control method for steering colloidal particles with chemical gradients using nonlinear model predictive control with a model based …


Dynamics Of Gametes And Embryos In The Oviduct: What Can In Vivo Imaging Reveal? Feb 2023

Dynamics Of Gametes And Embryos In The Oviduct: What Can In Vivo Imaging Reveal?

Faculty, Staff and Students Publications

IN BRIEF: In vivo imaging of gametes and embryos in the oviduct enables new studies of the native processes that lead to fertilization and pregnancy. This review article discusses recent advancements in the in vivo imaging methods and insights which contribute to understanding the oviductal function.

ABSTRACT: Understanding the physiological dynamics of gametes and embryos in the fallopian tube (oviduct) has significant implications for managing reproductive disorders and improving assisted reproductive technologies. Recent advancements in imaging of the mouse oviduct in vivo uncovered fascinating dynamics of gametes and embryos in their native states. These new imaging approaches and observations are …


Broad Protective Vaccination Against Systemic Escherichia Coli With Autotransporter Antigens, Dylan M Chirman, Sabrina Green, Jacob J Zulk, Joseph Jelinski, Kathryn A Patras, Anthony W Maresso Feb 2023

Broad Protective Vaccination Against Systemic Escherichia Coli With Autotransporter Antigens, Dylan M Chirman, Sabrina Green, Jacob J Zulk, Joseph Jelinski, Kathryn A Patras, Anthony W Maresso

Faculty, Staff and Students Publications

Extraintestinal pathogenic Escherichia coli (ExPEC) is the leading cause of adult life-threatening sepsis and urinary tract infections (UTI). The emergence and spread of multidrug-resistant (MDR) ExPEC strains result in a considerable amount of treatment failure and hospitalization costs, and contribute to the spread of drug resistance amongst the human microbiome. Thus, an effective vaccine against ExPEC would reduce morbidity and mortality and possibly decrease carriage in healthy or diseased populations. A comparative genomic analysis demonstrated a gene encoding an invasin-like protein, termed sinH, annotated as an autotransporter protein, shows high prevalence in various invasive ExPEC phylogroups, especially those associated with …


Modeling Ewing Sarcoma Lung Metastasis, Kimal Rajapakshe, Gargi Ghosal, Bikesh Nirala, Cristian Coarfa, Jason Yustein Feb 2023

Modeling Ewing Sarcoma Lung Metastasis, Kimal Rajapakshe, Gargi Ghosal, Bikesh Nirala, Cristian Coarfa, Jason Yustein

Faculty, Staff and Students Publications

Ewing Sarcoma (EwS) is the second most common malignant bone tumor in adolescents and young adults. The single-most powerful predictor of outcome in EwS is presence of metastatic burden at the time of diagnosis. Patients with metastatic Ewing Sarcoma have an abysmal 5-year survival rate of 10–25%, which has not changed over the past 30–40 years. Thus, unraveling underlying mechanisms of EwS metastasis are imperative for developing effective therapeutic measures. Investigations towards this goal are limited by the lack of reliable genetically engineered mouse models and specialized metastatic models. Using two established cell lines, A673 and TC71, we generated lung …


Early Life Reprogramming-Based Treatment Promotes Longevity Feb 2023

Early Life Reprogramming-Based Treatment Promotes Longevity

Faculty, Staff and Students Publications

Short-term expression of Yamanaka factors early in life promotes epigenetic reprogramming and an increased healthy lifespan in a mouse model of accelerated aging.