Digital Commons Network^™

The Last Werewolf: An Interactive Narrative About Bipolar Disorder, Rebecca Kerr

Staff Scholarship - Australia & Dubai

The Last Werewolf is an interactive narrative game exploring lived experiences of bipolar disorder through metaphor and emotional design. Drawing on the creator’s personal perspective, the game uses cyclical transformation as a lens for understanding mood episodes and identity fragmentation. The showcase presentation examined how mechanics and narrative structure were used to embody bipolar experiences, aiming to foster empathy and nuanced mental health representation in games. By integrating creative practice with research, The Last Werewolf demonstrates how independent games can meaningfully communicate complex psychological realities through interactive storytelling.

The Importance Of Treating Migraine Attacks Early - Even In Youth: A Real-World Argument For Neuromodulation, Mario F. P. Peres, Hsiangkuo Yuan, Cristina Tassorelli

Department of Jefferson Headache Center Papers and Presentations

No abstract provided.

Montana Kaimin, October 9, 2025, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

Polychlorinated Biphenyls Alter Estrogen Receptor Β-Mediated Epigenetic Regulation, Promoting Endometriosis, Yuri Park, Nuri Sung, Eunsu Kim, Jaeyeong Jeong, Juhee Sim, Mi Jin Park, John P Lydon, Xiaoming Guan, Sang Jun Han

Faculty, Staff and Students Publications

Endometriosis is a pathological condition characterized by the ectopic growth of endometrial cells, leading to chronic pelvic pain and infertility. Epidemiological studies have associated exposure to dioxin-like polychlorinated biphenyls, particularly PCB126, with an increased risk of endometriosis. However, the underlying mechanisms of this association remain poorly understood. We utilized a surgically induced endometriosis mouse model and human endometrial cell lines to assess the impact of PCB126 on endometriosis progression. Mice were exposed to environmentally relevant doses of PCB126. Endometriotic lesion growth, estrogen receptor signaling, receptor tyrosine kinase activity, and gene expression changes induced by PCB126-mediated elevation of DNA methyltransferase 3A …

Dual Targeting Of Orphan Nuclear Receptors Nr4a1 And Nr4a2 For Nonhormonal Endometriosis Therapy, Wai Ning Tiffany Tsui, Yuri Park, Srijana Upadhyay, Da Mi Kim, Lei Zhang, Gus Wright, Amanuel Hailemariam, Arafat Rahman Oany, Sang Jun Han, Stephen Safe

Faculty, Staff and Students Publications

Previous studies show that orphan nuclear receptor 4A1 (NR4A1) regulates endometriotic cell growth, survival, estrogen receptor β (ERβ), mechanistic target of rapamycin signaling and fibrosis. NR4A2 is also expressed in epithelial and stromal derived endometriotic cells, and in this study the effects of 1,1-bis(3'-indolyl)-(3,5-disubstitutedphenyl)methane (DIM-3,5) dual NR4A1/nuclear receptor 4A2 (NR4A2) ligands and knockdown of NR4A1 and NR4A2 were investigated. The dual NR4A1/2 DIM-3,5 analogs inhibited previously identified proendometriotic pathways and gene products, and they also inhibited TWIST1 and multiple markers associated with epithelial-to-mesenchymal transition (EMT). The results show that both NR4A1 and NR4A2 regulate the same pathways, including endometriotic cell …

Combatting Wildlife Smuggling, Andrew Rowan, Steven Hansch

WellBeing News

The illegal wildlife trade, valued at tens of billions annually, presents a major conservation and law-enforcement challenge; this article examines how novel forensic techniques (e.g. biometric hand-print matching, DNA analysis) are empowering authorities to trace trafficked specimens and prosecute operators. It argues that while promising, these methods require further development, broader deployment, and stronger legal frameworks to truly shift the balance against organized wildlife crime.

Alternatives To Laboratory Animals: The Evolution Of A Goal And Its Eventual Fulfilment, Andrew Rowan

WellBeing News

The article reviews the conceptual and institutional evolution of the alternatives-to-animals movement, from its inception and the articulation of the 3Rs framework to the progressive decline in laboratory animal use and rise of nonanimal methods. It argues that contemporary advances in in vitro and in silico technologies now realize the long­sought goal of meaningful replacement in many domains of biomedical research.

Positive Animal Welfare, Andrew Rowan

WellBeing News

Over the past decades, animal welfare science has progressed from focusing on alleviating suffering toward incorporating the study of positive affective states and flourishing experiences. This article reviews the concept of Positive Animal Welfare, its historical roots, recent scientific advances, and emerging metrics (e.g., Welfare Footprint) to support its integration into policy, research, and sustainability frameworks.

Tinkering With The Machinery Of Death: Execution Through Nitrogen Hypoxia, Emiliano Villarreal

The Scholar: St. Mary's Law Review on Race and Social Justice

The modern era of the death penalty in the United States began in 1976 when the Supreme Court reinstituted the death penalty just four years after having found it to be unconstitutional. Since then, various states, as well as the federal government, have experimented with different methods of execution to find the most “humane” way of carrying out an execution. In 2018, Alabama legalized the use of nitrogen hypoxia as a method of execution, and in 2024, became the first state to execute a person with this new, previously untested method. However, the use of nitrogen hypoxia has been the …

Reference At A Remote Field Station: A Case Study Of Ecology, Environmental Science And Geology Fieldwork At An Embedded Library, Thomas Gerrish

Libraries Faculty and Staff Scholarship and Research

Purpose Field station libraries, particularly those serving biological and marine research stations, represent a unique but understudied class of special libraries. This case study investigates reference services at the remote University of Michigan Biological Station (UMBS) to provide a baseline assessment of how such services support the information needs related to research in ecology, geology and environmental science.

Design/methodology/approach The study recorded, coded and analyzed 209 reference transactions from the 2022 and 2023 summer sessions, revealing trends in patron inquiries and the role of the reference desk. Further, the case study examined the organizational structure, community interaction and mission of …

The Cowl - V. 89 N. 4 - October 9, 2025

The Cowl

The Cowl - student newspaper of Providence College. Vol. 89 No. 4 - October 9, 2025. 16 pages.

Spartan Daily, October 9, 2025, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2025

Volume 165, Issue 21

Comprehensive Analysis Of The Tumor Targeting Efficiency Of Functionalized Nanoparticles In An Immunocompetent Environment, Nolan Jackson, Nasry Bouzeineddine, Daniel Cecchi, Safara Holder, Katrina Gee, Wayne Beckham, Sameh Basta, Sunil Krishnan, Devika B Chithrani

Faculty, Staff and Student Publications

The success of nanoparticle-based cancer therapeutics relies on their efficient tumor uptake and retention. Given this, improving nanoparticle localization in tumors is paramount to maximize their therapeutic potential. A common approach to achieve this is to functionalize nanoparticles with active targeting moieties that bind to specific tumor-associated receptors. Among these, arginine-glycine-aspartic acid (RGD) peptides have shown a potential to promote tumor accumulation by targeting the ανβ3 integrin receptor, a receptor commonly overexpressed by tumors owing to its role in promoting angiogenesis, metastasis and proliferation. Yet, its efficacy is commonly assessed using immunocompromised mice models. While useful, these models do not …

Geogenie: A Deep Learning Approach To Predict Geographic Provenance Of Biodiversity Samples From Genomic Snps, Bradley T. Martin, Zachery D. Zbinden, Michael E. Douglas, Marlis R. Douglas, Tyler K. Chafin

Biological Sciences Faculty Publications and Presentations

Motivation

Determining geographic origin of samples is a common objective in wildlife management, forensics, and conservation. Current methods often assume evolutionary models or require extensive reference datasets, which are costly and difficult to develop, that perform poorly with uneven or biased sampling. Supervised deep learning offers a promising alternative by learning complex patterns without prior model specifications. Combined with novel geo-genetic data augmentation and preprocessing techniques, it can reduce reference panel demands and improve performance across diverse sampling schemes, broadening accurate provenance determination to more study systems. Results

We present GeoGenIE, an open-source software package powered by PyTorch for geographic …

Sers And Seira Detection Of Polycyclic Aromatic Hydrocarbons And Their Derivatives In Murine Tissues: Bioaccumulation And Clearance, Oara Neumann, Andrés B Sánchez-Alvarado, Weiwu Jiang, Guo Dong Zhou, Sachin B Jorveka, Parmeet Dhindsa, Nagireddy Putluri, Peter Nordlander, Melissa A Suter, Bhagavatula Moorthy, Naomi J Halas

Faculty, Staff and Students Publications

The toxicological effects of polycyclic aromatic hydrocarbons (PAHs) and polycyclic aromatic compounds (PACs) have attracted considerable research interest due to their known bioaccumulation. However, time-resolved and longitudinal studies that examine in vivo bioaccumulation and clearance remain limited. Here we use Surface-Enhanced Raman Scattering (SERS) and Surface-Enhanced Infrared Absorption (SEIRA) spectroscopies to detect and track the presence of two PAHs: pyrene, benzo[a]pyrene, and one PAC: 5,12-naphthacenequinone, in murine organ tissues. Mice were exposed to a three-component mixture of these three chemicals, then their organs were collected at 24-, 48-, and 72- hours post-exposure. The accumulation of each of these chemicals in …

Ai In Adipose Imaging: Revolutionizing Visceral Adipose Tissue, Ectopic Fat, And Cardiovascular Risk Assessment, Sneha R. Kandi, Sanjay Rajagopalan, Ian J. Neeland

Faculty Scholarship

Purpose of Review: This review explores the role of artificial intelligence (AI) in visceral adipose tissue (VAT) and ectopic fat imaging. It aims to evaluate how AI may be used to enhance the efficiency and accuracy of cardiovascular disease (CVD) risk assessment. It addresses key questions regarding AI’s capabilities in risk prediction, segmentation, and integration with large volume data for CVD risk assessment. Recent Findings: Recent studies demonstrate that AI, powered by deep learning models, significantly improve VAT and ectopic fat segmentation. AI can also be used to facilitate early detection of cardiometabolic risks and allows integration of imaging with …

Coastal Water Information Orders: Reverse-Engineering New York City’S Data Dashboards, James A. Hodges, Rachel Paprocki

Faculty Research, Scholarly, and Creative Activity

This article examines the information systems governing individual relationships to urban coastal waterways, drawing from two data publication initiatives in New York City. In these two cases, data structure and web design features cultivate specific forms of knowledge about water quality, pollution, and the health risks represented by recreational activities such as swimming and fishing. Analysis of the data structure and web source code shows the forms of knowledge concerning water quality each project facilitates or obscures. Findings are considered within the framework of an ‘information order’, which refers to the prevailing conditions for knowledge that are facilitated by communication …

Acceleration Metrics Predict Propulsive Power At Within-Dive Temporal Scales In California Sea Lions, Mason R. Cole, Elizabeth A. Mchuron, Dan P. Costa, Paul J. Ponganis, Birgitte I. Mcdonald

Faculty Research, Scholarly, and Creative Activity

Background: Locomotion can drive variation in an animal’s energy expenditure, but the energetic cost of movement is difficult to measure at fine time scales in free-living animals. The 3 axis acceleration metrics Dynamic Body Acceleration (DBA) and Minimum Specific Acceleration (MSA) are commonly used in biologging studies as a proxy for activity or energy expenditure. These metrics hold potential for relatively simple and affordable estimates of movement-based energy expenditure, but have not been validated for use at fine temporal scales (e.g., within dives) due to logistical limitations of metabolic measurement techniques. Here, we use rates of propulsive power (W kg …

Salmon Rushdie’S Frontier Pedagogy: Notes On Two Episodes In “Step Across This Line", Narayana Chandran Kizhakkethil

Asian American Literature: Discourses & Pedagogies

In the Indian multilingual classrooms teachers often discover certain details about the political semantics of the English texts they teach. When that happens, the language means much more to non-English readers who happily realize that English grants them a little more freedom to convey meanings to them than it does a monolingual readership. My example here is Salman Rushdie’s Tanner Lectures in Human Values called “Step Across This Line.” While his immediate context is the 9/11 tragedy and the politically prudent ways the US might cope with its aftermath, he returns time and again to those who brave borders, face …

Without Them, There Is No You: The Role Of Personal Choice And History In Resisting Political Control, Heidi Turner

Asian American Literature: Discourses & Pedagogies

In 2011, Korean-American journalist Suki Kim went undercover as an English teacher at the Pyongyang University of Science and Technology, working to teach her students while simultaneously recording everything she could about the workings of the Democratic People’s Republic of Korea (DPRK). In 2014, her book Without You, There is No Us was published as a memoir, in part due to the inclusion of personal details considered less relevant to the story, thereby undercutting her journalistic credentials.

Here, using C. S. Lewis’s The Abolition of Man as a theoretical framework for understanding oppressive regimes and the ways that they control …

Full Circle, Full Century: An Interview With Mitsuye Yamada, Noelle Brada-Williams, Elizabeth J. Asborno

Asian American Literature: Discourses & Pedagogies

No abstract provided.

2022 - Appalachian Student Research Forum Award Winners, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

2022 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

2019 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

2019 - Appalachian Student Research Forum Award Winners, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

Co-Creation As A Trust-Building Tool: An Application To Ghanaian Local Governments, Richard K. Nkrumah

Journal of Public Management & Social Policy

none

The Uncanny, The October 7 Massacre, And The Folktale “The Wolf And The Kids” (Atu 123), Ravit Raufman

Jewish Folklore and Ethnology

Following Freud’s claim that folktales do not necessarily evoke uncanny experiences, this essay presents a case in which a folktale brought to life in the form of real-world events evokes uncanny experiences. The essay examines testimonies from the October 7 events in light of the folktale identified as “The Wolf and the Kids” (ATU 123) and proposes that beyond the horrors that occurred in the massacre, the comparative discussion reveals an additional level of terror, related to the way fairy tale experiences take on flesh and bone.

Theorizing Rabbinic Folklore: The Miraculous Sleep Of The Holy Man, Gal Sela

Jewish Folklore and Ethnology

The miraculous sleep (ATU 766) is a well-known, recurring tale-type observed in Abrahamic folktales since the Second Temple period. This study compares variants of ATU 766 on three levels of analysis: as a popular tale in Jewish, Christian, and Muslim writings from late antiquity and early medieval times; as a Jewish rendition; and as a multiple tale-type in rabbinic literature. The analysis engages with Dan Ben-Amos’s critical work concerning the use of syntactic methods in folklore studies to analyze Midrash and Aggadah. The essay offers a new theoretical perspective on rabbinic folklore using the notions of tale-type, ecotype, …

Asynchronous Reliable Transmission Protocol For Application-To-Application Communication, Ashish Kumar Khatri Mr., Preet Nepolean Dabre

Defensive Publications Series

Techniques are disclosed for providing asynchronous reliable transmission (ART) protocol for Application-to-Application messages. A communication protocol is designed to support communication between two devices asynchronously over channels that have limitations to facilitate asynchronous communication and have limited bandwidth. The ART protocol solves communication challenges that arise when transmitting data over channels with such limitations. The ART protocol has the provision to expand for future use cases such as encryption. Further, the ART Protocol provides mechanisms for data packet fragmentation, allowing larger packets to be transmitted over channels with limited bandwidth.

Common Loon Kills Bald Eagle In Defense Of Chick, Danni Dickson

Ontario Birds

No abstract provided.