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2023

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The Defined Tlr3 Agonist, Nexavant, Exhibits Anti-Cancer Efficacy And Potentiates Anti-Pd-1 Antibody Therapy By Enhancing Immune Cell Infiltration, Seung-Hwan Lee, Young-Ho Choi, Soon Myung Kang, Min-Gyu Lee, Arnaud Debin, Eric Perouzel, Seung-Beom Hong, Dong-Ho Kim Dec 2023

The Defined Tlr3 Agonist, Nexavant, Exhibits Anti-Cancer Efficacy And Potentiates Anti-Pd-1 Antibody Therapy By Enhancing Immune Cell Infiltration, Seung-Hwan Lee, Young-Ho Choi, Soon Myung Kang, Min-Gyu Lee, Arnaud Debin, Eric Perouzel, Seung-Beom Hong, Dong-Ho Kim

Faculty, Staff and Student Publications

Nexavant was reported as an alternative to the TLR3 agonist of Poly(I:C) and its derivatives. The physicochemical properties, signaling pathways, anti-cancer effects, and mechanisms of Nexavant were investigated. The distinctive characteristics of Nexavant compared to that of Poly(I:C) were demonstrated by precise quantification, enhanced thermostability, and increased resistance to RNase A. Unlike Poly(I:C), which activates TLR3, RIG-I, and MDA5, Nexavant stimulates signaling through TLR3 and RIG-I but not through MDA5. Compared to Poly(I:C), an intratumoral Nexavant treatment led to a unique immune response, immune cell infiltration, and suppression of tumor growth in various animal cancer models. Nexavant therapy outperformed anti-PD-1 …

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Ewsr1::Atf1 Orchestrates The Clear Cell Sarcoma Transcriptome In Human Tumors And A Mouse Genetic Model, Benjamin B Ozenberger, Li Li, Emily R Wilson, Alexander J Lazar, Jared J Barrott, Kevin B Jones Dec 2023

Ewsr1::Atf1 Orchestrates The Clear Cell Sarcoma Transcriptome In Human Tumors And A Mouse Genetic Model, Benjamin B Ozenberger, Li Li, Emily R Wilson, Alexander J Lazar, Jared J Barrott, Kevin B Jones

Faculty, Staff and Student Publications

Clear cell sarcoma (CCS) is a rare, aggressive malignancy that most frequently arises in the soft tissues of the extremities. It is defined and driven by expression of one member of a family of related translocation-generated fusion oncogenes, the most common of which is EWSR1::ATF1. The EWSR1::ATF1 fusion oncoprotein reprograms transcription. However, the binding distribution of EWSR1::ATF1 across the genome and its target genes remain unclear. Here, we interrogated the genomic distribution of V5-tagged EWSR1::ATF1 in tumors it had induced upon expression in mice that also recapitulated the transcriptome of human CCS. ChIP-sequencing of V5-EWSR1::ATF1 identified previously unreported motifs …

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Designing An Artificial Immune Inspired Intrusion Detection System, William Hosier Anderson Dec 2023

Designing An Artificial Immune Inspired Intrusion Detection System, William Hosier Anderson

Theses and Dissertations

The domain of Intrusion Detection Systems (IDS) has witnessed growing interest in recent years due to the escalating threats posed by cyberattacks. As Internet of Things (IoT) becomes increasingly integrated into our every day lives, we widen our attack surface and expose more of our personal lives to risk. In the same way the Human Immune System (HIS) safeguards our physical self, a similar solution is needed to safeguard our digital self. This thesis presents the Artificial Immune inspired Intrusion Detection System (AIS-IDS), an IDS modeled after the HIS. This thesis proposes an architecture for AIS-IDS, instantiates an AIS-IDS model …

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Radiative Alpha Capture On Carbon-12, Ling Gan Dec 2023

Radiative Alpha Capture On Carbon-12, Ling Gan

Theses and Dissertations

In this thesis, we used Effective Field Theory (EFT) to calculate the radiative ALPHA capture on 12C . This reaction is considered the “holy grail” in nuclear astrophysics because it determines the relevant abundance of 16O and 12C . We considered the E1 transition from initial p-wave at energy around the Gamow energy EG =0.3MeV.The theoretical formula for the cross section is obtained by fitting the EFT parameters to the phase shift and S-factor data. We find the Effective Range Expansion (ERE) parameters describing the ALPHA-wave phase shift are fine tuned. The shallow bound state and the resonance ALPHA-wave …

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Hypothalamic Manipulation Of The Anuran Hpg Axis: Alternative Hormones And A Non-Invasive Administration Route For Amphibian Assisted Reproductive Technologies (Art), Erin Michelle Saylor Dec 2023

Hypothalamic Manipulation Of The Anuran Hpg Axis: Alternative Hormones And A Non-Invasive Administration Route For Amphibian Assisted Reproductive Technologies (Art), Erin Michelle Saylor

Theses and Dissertations

Amidst the amphibian extinction crisis, in situ and ex situ amphibian species conservation initiatives utilize assisted reproductive technologies for optimal genetic management of captive and wild populations. Development of effective, simple, low-cost methods for obtaining gametes for artificial fertilization, sperm biobanking, or natural breeding alleviates obstacles for institutions or programs to apply reproductive technologies. Objectives herein include investigating the efficacy of alternative hormones for inducing spermiation, an alternative hormone administration route for inducing ovulation, exploring the physiological effects of hormone therapy, and utilizing sperm from deceased animals for biobanking.

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Development Of An Automated Delivery System To Apply Copper Sulfate Crystals Using Precision Dry Fertilizer Application Technology, Kevin Charles Wise Dec 2023

Development Of An Automated Delivery System To Apply Copper Sulfate Crystals Using Precision Dry Fertilizer Application Technology, Kevin Charles Wise

Theses and Dissertations

The digenetic trematode, Bolbophorus damnificus, poses a substantial threat to catfish aquaculture, causing significant economic losses. Infestations lead to suppressed feed consumption, secondary bacterial infections and poor production performance. Survey data reveals widespread infestation in the in the southeastern United States. Current control strategies involve the application of a concentrated copper sulfate solution to reduce snail populations which serve as the first intermediate host of the trematode life cycle. This study aimed to improve treatment efficacy by developing a granular copper sulfate application system. A modified Gandy fertilizer applicator, equipped with a programmable control system, demonstrated accurate distribution of copper …

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Evaluation Of Cultivar Susceptibility And In-Furrow Fungicide Efficacy For Management Of Southern Blight Of Soybean, Adam Joseph Connor Dec 2023

Evaluation Of Cultivar Susceptibility And In-Furrow Fungicide Efficacy For Management Of Southern Blight Of Soybean, Adam Joseph Connor

Theses and Dissertations

Southern Blight (SB), caused by the fungus Athelia rolfsii, has increasingly impacted Mississippi soybean production with estimated economic losses in recent years rising from $181,616 in 2016 to $9,508,412 in 2021. Currently, there are no recommended fungicides and no known commercially available cultivar resistance. Eleven cultivars were evaluated for their response to the presence of Athelia rolfsii in the 2021 field trial. An in vitro fungicide assay was conducted to evaluate the efficacy of five fungicides to determine the respective EC50. These fungicides were then evaluated in combination with three cultivars, one mild, one moderate, and one severe in the …

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Flood Inundation Mapping Of The Catalpa Creek Watershed, Subodh Poudel Dec 2023

Flood Inundation Mapping Of The Catalpa Creek Watershed, Subodh Poudel

Theses and Dissertations

This study addresses flood risk assessment in the Catalpa Creek watershed, located in northeast Mississippi, USA. Employing the Hydrological Modeling System (HEC-HMS) and the River Analysis System (HEC-RAS), integrated models were developed and calibrated, to predict flood behavior within the watershed. The study conducted flood frequency analyses for return periods ranging from 2 to 100 years and generated flood inundation maps, pinpointing flood-prone areas. Mitigation measures for flood risk management were recommended. The results underscore the effectiveness of the integrated modeling approach for simulating and understanding the complex dynamics of flood events. The research identified critical flood-prone zones, emphasizing the …

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Effects Of Electrical Stimulation On Water-Soluble Flavor Compounds In Beef Semimembranosus Muscle, Chelsie Beebe Dec 2023

Effects Of Electrical Stimulation On Water-Soluble Flavor Compounds In Beef Semimembranosus Muscle, Chelsie Beebe

Theses and Dissertations

This study examined the effects of electrical stimulation on water-soluble flavor compounds in beef semimembranosus muscle, collected immediately after exsanguination (PRE), immediately after stimulation (POST), and 24 h postmortem (H24) from both stimulated (ES) and non-stimulated (CON) carcasses. Short-chained peptides were greater in ES at H24 (P = 0.007). Glutamic acid concentration was above its taste threshold (0.044 mmol/kg) and was less in ES at PRE and POST by 0.030 mmol/kg (P ≤ 0.028) but was similar in both ES and CON by H24 (P = 0.142). Lysine, a Strecker amino acid, was greater in ES at H24 by 0.138 …

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The Impact Of Prior Pandemic Planning On Health Outcomes During The Covid-19 Pandemic: A Study Of Local Government Pandemic Planning In The United States, Karissa D. Bergene Dec 2023

The Impact Of Prior Pandemic Planning On Health Outcomes During The Covid-19 Pandemic: A Study Of Local Government Pandemic Planning In The United States, Karissa D. Bergene

Theses and Dissertations

In late 2019, scientists discovered a novel strain of coronavirus originating out of Wuhan, China. By January 2020, the United States (U.S.) saw its first positive case of coronavirus and the public was still unsure how serious of an epidemic this would be. By the time the World Health Organization declared the novel coronavirus disease (COVID-19) epidemic a “global pandemic” on March 11, 2020, world leaders, public health experts, scientists, and public administrators kicked into high gear to start serious pandemic response efforts. The public sector is typically the responsible authority for the preparedness, response, mitigation, and recovery of such …

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Stream Water Quality Under Baseflow Conditions In A Livestock Production Area, Maryi Lorena Chavarro Chaux Dec 2023

Stream Water Quality Under Baseflow Conditions In A Livestock Production Area, Maryi Lorena Chavarro Chaux

Theses and Dissertations

This study evaluates the spatial and temporal impacts of implemented Best Management Practices (BMP) on stream water quality under baseflow conditions in a stream segment affected by livestock production. The BMPs includes 10-m fenced riparian zone and crossing paths along the reach segment. Grab water samples and water quality monitoring were collected biweekly from July 2019 to March 2022. Water quality parameters included temperature, dissolved oxygen, electric conductance, total dissolved solids, turbidity, and pH. Water samples were lab analyzed for sediments and nutrients. Results evidenced poor water quality before BMPs implementation, with nutrient concentrations exceeding the nation's and state's criteria. …

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Advancing Salamander Conservation Efforts In Zoos And Aquaria Through Assisted Reproductive Technologies (Art), Devin Marie Chen Dec 2023

Advancing Salamander Conservation Efforts In Zoos And Aquaria Through Assisted Reproductive Technologies (Art), Devin Marie Chen

Theses and Dissertations

Salamanders are one of the most at-risk taxa in the world due to habitat destruction, pollution, climate change, invasive diseases, and more. This has led to a need for conservation breeding programs that are often associated with zoos and aquaria. Salamanders can be difficult to breed in captivity, though, due to their dependence on specific environmental cues and other unknown factors that stimulate sperm and egg production. To overcome these challenges, assisted reproductive technologies (ART) such as exogenous hormone administration, sperm cryopreservation, and in-vitro fertilization have been developed to increase offspring propagation and maintain genetic diversity. If genetically robust populations …

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We Built This Country For Free – Using A Phenomenological Approach For (Re) Imagining Mississippi Black Small-Scale Farmers, Destiny Denise Crockett Dec 2023

We Built This Country For Free – Using A Phenomenological Approach For (Re) Imagining Mississippi Black Small-Scale Farmers, Destiny Denise Crockett

Theses and Dissertations

By the early 20th century, in 1920, Black farmers owned 14% of US farmland. Today, in the 21st century, Black farmers own less than 2% of US farmland. The demise of Black farmers and Black farmland in US Agriculture is a direct result of social, political, and racial weaponization against their foodways, culture, and livelihoods. The history concerning the plight of Black farmers goes beyond USDA's historical discrimination but enters a position where racism is embedded and perpetuated within the structure of US agriculture. In effect, Black small-scale farmers have reaped the downfall of this system, enduring racial biases and …

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Design, Development, And Validation Of A Perfusion-Compression Bioreactor To Study Osteogenesis In Bone Explants, Alexis Victoria Graham Dec 2023

Design, Development, And Validation Of A Perfusion-Compression Bioreactor To Study Osteogenesis In Bone Explants, Alexis Victoria Graham

Theses and Dissertations

The current gold standard treatment for bone defects is autologous cancellous bone graft, which involves increased surgery time and donor site morbidity, and limited supply of bone and cells for regeneration. Bioreactors may aid in the generation of mechanically conditioned bone grafts with more cells compared to traditional grafts. However, the specific parameters of fluid flow and mechanical loading which contribute to osteogenesis and cell viability in bioreactors are not fully characterized. Here, a perfusion-compression bioreactor system was developed to study osteogenesis in porcine trabecular bone explants. Loading accuracy was over 88% across six bioreactors at a 0.1 s-1 strain …

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The Migration Ecology Of North American Turkey Vultures Wintering In The Neotropics: Spatial And Population Dynamics, Adrián José Naveda-Rodríguez Dec 2023

The Migration Ecology Of North American Turkey Vultures Wintering In The Neotropics: Spatial And Population Dynamics, Adrián José Naveda-Rodríguez

Theses and Dissertations

The spatial and population dynamics of avian scavengers are poorly understood. This information is key for management and conservation interventions that guarantee long-term species conservation. My goal in this dissertation is to fill information gaps on the movement ecology of New World vultures using the Turkey Vulture (Cathartes aura) as a model species. I used a continental-wide satellite telemetry dataset to study the migration ecology, space-use, and demography of the three North American breeding populations of Turkey Vultures wintering in the Neotropics during a 17-year period. I found that primary productivity, but not weather, triggered Turkey Vulture migratory …

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Developing A Precision Agriculture Framework To Assess Financial Viability Of Decisions In Farming And Conservation, Jennifer Sublett Dec 2023

Developing A Precision Agriculture Framework To Assess Financial Viability Of Decisions In Farming And Conservation, Jennifer Sublett

Theses and Dissertations

Agricultural producers are invested in managing the impacts of crop damage on their yields and profit. When damage occurs early enough in an agricultural growing season, farmers have the option to replant their corn stand in an effort to recoup some of the lost profits. In this thesis two different types of naturally occurring damage, wildlife depredation and persistent weed or insect patches, were simulated on two representative regions of Mississippi. These data were then used to assess the financial viability of a range of damage mitigation methods, including partial replanting, enrollment into a government conservation buffer, and no action. …

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Assessing The Relationship Between Soil Health/Quality And Water Quality In The Mississippi Delta, Laura Andrea Sarmiento Rodriguez Dec 2023

Assessing The Relationship Between Soil Health/Quality And Water Quality In The Mississippi Delta, Laura Andrea Sarmiento Rodriguez

Theses and Dissertations

Several studies have reported agronomic benefits by improving soil health/quality, but uncertain knowledge remains when determining specific impacts on water quality off-field. This study investigated the links between runoff water quality and soil health/quality in agricultural fields of the Mississippi delta under three land management scenarios: Conservation Reserve Program (CRP), vegetative buffer (VB), and row crops (RC). Using the Soil Management Assessment Framework (SMAF), a Soil Quality Index (SQI) was obtained based on ten soil health/quality indicators from 2008 and 2012 datasets. The SMAF identified significant differences in soil health/quality improvements among scenarios over a four-year period. Varied relationships between …

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Current And Future Perceived Needs And Concerns For Older Adults Aging In Place In Mississippi: Intergenerational Perspectives, Muhammad Riaz Dec 2023

Current And Future Perceived Needs And Concerns For Older Adults Aging In Place In Mississippi: Intergenerational Perspectives, Muhammad Riaz

Theses and Dissertations

The study's purpose was to identify the perceived needs and concerns of three generations in a family with an older adult aging in place in Mississippi. This mixed-methods study used snowball sampling in addition to recruitment by community leaders such as Extension agents to collect data through semi-structured interviews and structured questionnaires that asked about current and future problems among aging adults in rural communities in Mississippi. Three generations of Mississippians participated in the study, including older adults (G1; n = 22), adult children (G2; n = 23), and young adult grandchildren (G3; n = 19). Quantitative data were analyzed …

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Paternal Programming: The Role Of Seminal Plasma In Pregnancy Hemodynamics And Offspring Growth, Rebecca Michele Swanson Dec 2023

Paternal Programming: The Role Of Seminal Plasma In Pregnancy Hemodynamics And Offspring Growth, Rebecca Michele Swanson

Theses and Dissertations

Seminal plasma is commonly known to serve as a transport medium for sperm as it moves through the female reproductive tract for fertilization, however, more recent evidence demonstrates seminal plasma induces an expansive inflammatory response in the uterus. Murine models have found this inflammatory response is important for clearing pathogens and poor-quality sperm, eliciting the secretion of cytokines, chemokines, and embryokines that aid in embryo attachment and growth, placental angiogenesis, and blunting maternal immunity to the embryo. However, there is minimal research on the impacts of seminal plasma uterine priming in bovine, and more specifically embryo growth, uterine blood flow, …

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Effects Of Supplementing Sources Of Zinc On Digestibility Parameters Of Beef Steers, Arminda Spikes James Dec 2023

Effects Of Supplementing Sources Of Zinc On Digestibility Parameters Of Beef Steers, Arminda Spikes James

Theses and Dissertations

Zinc (Zn) has numerous functions and life sustaining processes depend on the presence of Zn within the body. Zinc sulfate is a common form of Zn supplemented in the beef industry. Inorganic sulfate based minerals have been associated with negative rumen effects, mainly, decreased rumen fermentation and protozoa numbers. Our studies concluded no difference in digestibility of three different forms of Zn (zinc glycinate, zinc sulfate, and zinc hydroxychloride). Although overall digestibility did not change, there were specific mineral concentration differences after steers consumed concentrate treatment for 10 days. These differences implied that the mineral fed was consumed and absorbed …

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Of Changing Climate And Habitat: Range-Wide Individual Growth And Local Patterns Of Phenology And Landscape Use In A Threatened Pit-Viper, James Helferich Dec 2023

Of Changing Climate And Habitat: Range-Wide Individual Growth And Local Patterns Of Phenology And Landscape Use In A Threatened Pit-Viper, James Helferich

Theses and Dissertations

Over the 21st century, climate change and wetland habitat loss will pose major threats to the Eastern Massasauga (Sistrurus catenatus), a federally threatened and Great Lakes region endemic rattlesnake. I collected capture-recapture data from sites across the range and modeled the effect of climatic variables on growth rate and asymptotic size. I found that high snow residence time was associated with larger asymptotic sizes but slower growth, while high spring precipitation increased growth rate. I then projected future growth and size under different carbon emission scenarios. Given the threat posed by successional encroachment of woody vegetation, I used spatially explicit …

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Towards Understanding The Interactions Between Ospreys And Human-Made Structures In The Tennessee River Valley, Natasha Karina Murphy Dec 2023

Towards Understanding The Interactions Between Ospreys And Human-Made Structures In The Tennessee River Valley, Natasha Karina Murphy

Theses and Dissertations

Raptor nests on human-built structures represent a significant source of conflict as they can result in bird mortality, fires, structure damage, service distribution, or power outages when falling nest materials or animals connect with energized conductors. Power companies, such as the Tennessee Valley Authority (TVA), wish to mitigate these conflicts to avoid service disruptions. In this dissertation, I present my work towards understanding and mitigating the interactions between Ospreys (Pandion haliaetus) and human-made structures. To achieve this, I explored multiple elements of conflict identification, monitoring, and basic ecology of the target species to better inform conflict mitigation. In Chapter I, …

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Evaluating The Greet-Stop-Prompt Intervention In Decreasing Racial Disparities In School Discipline, Alexandra Utley Dec 2023

Evaluating The Greet-Stop-Prompt Intervention In Decreasing Racial Disparities In School Discipline, Alexandra Utley

Theses and Dissertations

Exclusionary discipline practices are often considered to be generally ineffective and inequitable, however, they are one of the more common disciplinary practices used in schools today. Although there are many positive alternatives to school exclusion, there are limited disciplinary practices specifically intended to target discipline with racial equity in mind. The GREET-STOP-PROMPT (GSP) intervention, developed by Cook and colleagues (2018), is one intervention found in the literature explicitly created to reduce racial discipline disparities. Although there is currently limited research evaluating the GSP intervention, the results indicate it to be a potentially promising method of equitably addressing student behavior. The …

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Cement Stabilization Of Poorly Graded Sand, Lana Grayson Brown Sisung Dec 2023

Cement Stabilization Of Poorly Graded Sand, Lana Grayson Brown Sisung

Theses and Dissertations

Stabilization of poorly graded sand in full-scale applications is challenging. This thesis evaluated cement-stabilized sand and had two objectives: (1) evaluation of stabilized material using the PM device to quantify engineering properties for future comparison to alterative materials and to investigate the effectiveness of the device with sand and (2) investigation of the merits of alternative application of cement to sand to benchmark against other topically applied materials. The PM device was successfully used to recommend 10% cement for field studies with one sand, successfully allowed data collection in laboratory and field applications, and its potential in sand seems promising …

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Effects Of Wet Aging On Water-Soluble Flavor Compounds, Descriptive Flavor, Consumer Acceptability, And Willingness-To-Pay Of Beef Longissimus Lumborum Steaks, Shangshang Wang Dec 2023

Effects Of Wet Aging On Water-Soluble Flavor Compounds, Descriptive Flavor, Consumer Acceptability, And Willingness-To-Pay Of Beef Longissimus Lumborum Steaks, Shangshang Wang

Theses and Dissertations

This study examined the effects of wet aging on water-soluble flavor compounds, descriptive flavor, consumer acceptability, and willingness-to-pay of beef strip steaks. Twenty USDA Select boneless beef loins (NAMP #180) were dorsally divided into four equal portions, which were randomized to receive either 0, 7, 14, or 21 d of wet aging. Short-chained peptide concentration increased from 4.11 mg/g on d 0 to 5.12 mg/g on d 7 (P = 0.011) and subsequently increased to 7.14 mg/g on d 21 (P < 0.001). Cooked beef contained 1.85 mg/g less short-chained peptides than raw beef (P < 0.001). Wet aging for 21 d increased the concentrations of amino acids, which are precursors for the Maillard reaction, including methionine, threonine, cystine, serine, tryptophan, and phenylalanine (P < 0.001). Wet aging decreased the nucleotide concentrations (P ≤ 0.003) and increased hypoxanthine concentration, a compound that imparts bitter flavor (P …

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Increased Coding Potential Of Bovine Herpesvirus 1, Victoria Jefferson Dec 2023

Increased Coding Potential Of Bovine Herpesvirus 1, Victoria Jefferson

Theses and Dissertations

Bovine respiratory disease (BRD) costs the cattle industry millions of dollars in costs in treatment and loss every year in the United States. A significant pathogen often contributes to BRD is Bovine Herpesvirus 1 (BoHV-1), a double stranded DNA virus with the ability to establish latency in the trigeminal ganglia and neurons. Primary infection with BoHV-1 results in immunosuppression that increases the risk of secondary bacterial infection and pneumonia. Because herpesviruses infect their hosts for life and can be reactivated in times of stress, BoHV-1 can present a recurring risk of BRD. The following research aims to expand the knowledge …

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Opportunities For Mental Health Interventions In Rural Mississippi Communities During The Covid-19 Pandemic: A Quantitative Analysis, Brice Fortinberry Dec 2023

Opportunities For Mental Health Interventions In Rural Mississippi Communities During The Covid-19 Pandemic: A Quantitative Analysis, Brice Fortinberry

Theses and Dissertations

COVID-19 presented unique challenges for rural Mississippi communities including impacts on the mental health of rural individuals. This research study aimed to identify opportunities for mental health interventions to provide health promotion professionals with quantitative data on the accessibility and the likelihood of engagement with mental health-fostering behaviors. A secondary objective of this research was to categorize these behaviors within the constructs of the Social Ecological Model. Demographics for rural Mississippi communities were collected and displayed, and using multivariate analyses including Spearman’s correlation and a Mann-Whitney U test the correlation between mental health fostering behaviors and demographic factors was obtained. …

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Improved Herbicide Selectivity In Tomato By Safening Action Of Benoxacor, 2,4,6-T, Melatonin, And Fenclorim, Tabata Raissa De Oliveira Dec 2023

Improved Herbicide Selectivity In Tomato By Safening Action Of Benoxacor, 2,4,6-T, Melatonin, And Fenclorim, Tabata Raissa De Oliveira

Theses and Dissertations

Safeners protect crops by enhancing their ability to metabolize various compounds, including herbicides. They primarily work by increasing the crop's tolerance to herbicide damage, activating herbicide-metabolizing proteins, and aiding in their detoxification. This study aimed to investigate the chemical effects of safeners in tomato cultivation and focus on injury reduction and tissue protection. The experiment followed a randomized factorial design (5x4) with four replications repeated twice. We evaluated the effects of herbicides (dicamba, 2,4-D, metribuzin, and sulfentrazone at 1/100) and safeners (benoxacor, fenclorim, melatonin, 2,4,6-T, and an untreated control). Safeners were applied to the seeds before sowing, and herbicides were …

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Functional Role Of Toll-Like Receptor Associated Micrornas In Intervertebral Disc Pathophysiology, Petra Cazzanelli Dec 2023

Functional Role Of Toll-Like Receptor Associated Micrornas In Intervertebral Disc Pathophysiology, Petra Cazzanelli

Theses

Intervertebral disc (IVD) degeneration is one of the main contributing factors to low back pain (LBP), the leading cause of years lived in disability worldwide. The degenerative processes in the IVD tissue are characterized by the metabolic dysregulation of IVD cells and aberrant mechanical loading. The major hallmarks of this multifactorial pathology are the degradation of the extracellular matrix (ECM), inflammation, and cell loss. Inflammation has been specifically linked to the development of discogenic LBP, as increased secretion of pro-inflammatory cytokines can cause the infiltration of immune cells and nerve fibers. Toll-like receptors (TLR) are key regulators of inflammation, amongst …

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Determining The Potential Of Sonic Bloom In Inducing Rice Resistance (Oryza Sativa) Against The Attack Of Bacterial Leaf Blight Disease Caused By Xanthomonas Oryzae, Azka Algina, Syifaa Yunita Yulianti, Rohimatus Syamsyiah, Veadora Yasminingrum, Bergas Frenli Nur Vendi, Vira Kusuma Dewi Dec 2023

Determining The Potential Of Sonic Bloom In Inducing Rice Resistance (Oryza Sativa) Against The Attack Of Bacterial Leaf Blight Disease Caused By Xanthomonas Oryzae, Azka Algina, Syifaa Yunita Yulianti, Rohimatus Syamsyiah, Veadora Yasminingrum, Bergas Frenli Nur Vendi, Vira Kusuma Dewi

Jurnal Kultivasi

Xanthomonas oryzae which causes bacterial leaf blight disease is one of the main pathogens that attack rice crops. The threat of losing rice yields due to X. oryzae needs to be avoided by implementing appropriate control strategies. Sonic bloom has the potential to induce plant immunity against diseases. Hence, this study aimed to examine the potential of sonic bloom in inducing rice resistance to bacterial leaf blight. The experiment was arranged in a Randomized Block Design (RBD) with five treatments and three replications. The treatments consisted of several frequencies, namely PR (0.5 - 1 kHz and inoculated with X. oryzae), …

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