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2023

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Articles 1381 - 1410 of 24872

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Interleukin 31 Receptor Α Promotes Smooth Muscle Cell Contraction And Airway Hyperresponsiveness In Asthma, Santhoshi Akkenepally, Dan Yombo, Sanjana Yerubandi, Geereddy Bhanuprakash Reddy, Deepak Deshpande, Francis Mccormack, Satish Madala Dec 2023

Interleukin 31 Receptor Α Promotes Smooth Muscle Cell Contraction And Airway Hyperresponsiveness In Asthma, Santhoshi Akkenepally, Dan Yombo, Sanjana Yerubandi, Geereddy Bhanuprakash Reddy, Deepak Deshpande, Francis Mccormack, Satish Madala

Center for Translational Medicine Faculty Papers

Asthma is a chronic inflammatory airway disease characterized by airway hyperresponsiveness (AHR), inflammation, and goblet cell hyperplasia. Multiple cytokines, including IFNγ, IL-4, and IL-13 are associated with asthma; however, the mechanisms underlying the effects of these cytokines remain unclear. Here, we report a significant increase in the expression of IL-31RA, but not its cognate ligand IL-31, in mouse models of allergic asthma. In support of this, IFNγ, IL-4, and IL-13 upregulated IL-31RA but not IL-31 in both human and mice primary airway smooth muscle cells (ASMC) isolated from the airways of murine and human lungs. Importantly, the loss of IL-31RA …

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The Representation Of Third-Party Helping Interactions In Infancy, Laura Schlingloff-Nemecz, Denis Tatone, Gergely Csibra Dec 2023

The Representation Of Third-Party Helping Interactions In Infancy, Laura Schlingloff-Nemecz, Denis Tatone, Gergely Csibra

School of Psychology

Despite numerous findings on the sophisticated inferences that human infants draw from observing third-party helping interactions, currently there is no theoretical account of how infants come to understand such events in the first place. After reviewing the available evidence in infants, we describe an account of how human adults understand helping actions. According to this mature concept, helping is a second-order, goal-directed action aiming to increase the utility of another agent (the Helpee) via reducing the cost, or increasing the reward, of the Helpee's own goal-directed action. We then identify the cognitive prerequisites for conceiving helping in this way and …

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Acid Attack: How Escherichia Coli Strains Resist Acid Stress, Lindsey Miller Dec 2023

Acid Attack: How Escherichia Coli Strains Resist Acid Stress, Lindsey Miller

Honors Theses

The systems used by Escherichia coli to combat heightened levels of acidity within their environment are varied and complex. Four distinct systems used by E. coli to resist acid-induced stress were identified in 2004 by Foster (1), though six now are known today. These systems include the glucose-repressed, glutamate-dependent, arginine-dependent, lysine-dependent, ornithine-dependent, and serine-dependent acid resistance systems. Each system is also known by its corresponding abbreviation, AR1-AR6. What is known about each system varies due to identification date, complexity of the pathway, and amount of research completed. Within this paper, each system will be identified and the pathway defined, combining …

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Synthesis Of Yaku'amide A Analogues And Progress Toward Synthesis Of Virosine A, Alexander S. Ramos Dec 2023

Synthesis Of Yaku'amide A Analogues And Progress Toward Synthesis Of Virosine A, Alexander S. Ramos

Theses and Dissertations

The first project in this dissertation endeavors to outline the total synthesis of yaku'amide A and its analogs. Yaku'amide A is a natural product comprised of dehydroamino acids, including E-dehydro isoleucine, and unprecedented Z-dehydro isoleucine. These amino acids present a significant challenge to their synthesis owing to their unsymmetrical nature. To simplify the synthesis process, we synthesized analogs by substituting the E and Z dehydroamino acids with symmetrical subunits. This substitution facilitated the synthesis process and enabled us to obtain a similar three-dimensional structure to that of the natural product. Furthermore, biological testing of the simplified analogs revealed potency similar …

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Oregon State Rank Assessment For Yellow Bumblebee (Bombus Fervidus), Misty Nelson Dec 2023

Oregon State Rank Assessment For Yellow Bumblebee (Bombus Fervidus), Misty Nelson

Institute for Natural Resources Publications

Oregon state conservation status assessment for Yellow bumblebee (Bombus fervidus) using NatureServe methodology, 2023.

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Immunoproximity Biotinylation Reveals The Axon Initial Segment Proteome, Wei Zhang, Yu Fu, Luxin Peng, Yuki Ogawa, Xiaoyun Ding, Anne Rasband, Xinyue Zhou, Maya Shelly, Matthew N Rasband, Peng Zou Dec 2023

Immunoproximity Biotinylation Reveals The Axon Initial Segment Proteome, Wei Zhang, Yu Fu, Luxin Peng, Yuki Ogawa, Xiaoyun Ding, Anne Rasband, Xinyue Zhou, Maya Shelly, Matthew N Rasband, Peng Zou

Faculty, Staff and Students Publications

The axon initial segment (AIS) is a specialized neuronal compartment required for action potential generation and neuronal polarity. However, understanding the mechanisms regulating AIS structure and function has been hindered by an incomplete knowledge of its molecular composition. Here, using immuno-proximity biotinylation we further define the AIS proteome and its dynamic changes during neuronal maturation. Among the many AIS proteins identified, we show that SCRIB is highly enriched in the AIS both in vitro and in vivo, and exhibits a periodic architecture like the axonal spectrin-based cytoskeleton. We find that ankyrinG interacts with and recruits SCRIB to the AIS. However, …

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Humankind – Bias In Our Head, Luying Li Dec 2023

Humankind – Bias In Our Head, Luying Li

Theses

"HumanKind" is a dynamic exploration at the intersection of visual communication design and societal awareness, seeking to unravel and mitigate the far-reaching impacts of bias. Through the fusion of "Human" and "Kind," the project embodies a dual narrative, emphasizing individual humanity and the diverse fabric of the human collective. The core inquiry revolves around encouraging individuals to recognize and challenge biases before decision-making, fostering unbiased choices. Historical narratives of racial conflicts serve as the foundation, propelling the project's mission to explore, challenge, and diminish biases entrenched in our collective consciousness. Going beyond traditional exhibitions, "HumanKind" evolves into a dynamic dialogue …

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Cookool: A Futuristic Cooking Innovation, Guannan Ling Dec 2023

Cookool: A Futuristic Cooking Innovation, Guannan Ling

Theses

Cookool is a futuristic innovation project that utilizes real-time interactive design and technology to display cooking information seamlessly, aiming to create a cool, friendly, and relaxed cooking experience for everyone to try, learn, and fall in love with. In traditional kitchens, people often face various challenges such as choosing dishes and controlling temperatures. However, in the future, our kitchen will leverage AI technology to precisely recommend dishes based on personal preferences, utilize thermal detection to monitor utensil temperatures, and leverage hologram and AR technology to showcase recipes and cooking processes, making cooking simpler. Yet, technology alone cannot create an inclusive …

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Engineering Exosomes To Specifically Target The Mitochondria Of Brain Cells, Xin Yan, Xinqian Chen, Zhiying Shan, Lanrong Bi Dec 2023

Engineering Exosomes To Specifically Target The Mitochondria Of Brain Cells, Xin Yan, Xinqian Chen, Zhiying Shan, Lanrong Bi

Michigan Tech Publications

Mitochondrial dysfunction is associated with various health conditions, including cardiovascular and neurodegenerative diseases. Mitochondrial-targeting therapy aims to restore or enhance mitochondrial function to treat or alleviate these conditions. Exosomes, small vesicles that cells secrete, containing a variety of biomolecules, are critical in cell-to-cell communication and have been studied as potential therapeutic agents. Exosome-based therapy has the potential to treat both cardiovascular and neurodegenerative diseases. Combining these two approaches involves using exosomes as carriers to transport mitochondrial-targeting agents to dysfunctional or damaged mitochondria within target cells. This article presents a new technique for engineering brain-derived exosomes that target mitochondria and has …

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Oregon State Ranking Assessment For Morrison Bumblebee (Bombus Morrisoni), Misty Nelson Dec 2023

Oregon State Ranking Assessment For Morrison Bumblebee (Bombus Morrisoni), Misty Nelson

Institute for Natural Resources Publications

Oregon state conservation status assessment for Morrison bumblebee (Bombus morrisoni) using NatureServe methodology, 2023.

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Local Approaches To Address Global Challenges: Educating Local Innovators For Positive Social Change, Martha Leticia Silva-Flores, Melisa Ladrón De Guevara Dec 2023

Local Approaches To Address Global Challenges: Educating Local Innovators For Positive Social Change, Martha Leticia Silva-Flores, Melisa Ladrón De Guevara

Journal of Management for Global Sustainability

Aligning global concerns with local challenges is essential for achieving long-term sustainability. This entails addressing local communities’ needs and issues to develop effective and sustainable solutions. This approach not only benefits communities but also has the potential to impact the environment and society positively. Local innovators play a fundamental role in promoting sustainable development by devising creative and sustainable solutions to problems affecting their communities. However, in the case of local entrepreneurs in the Guadalajara Metropolitan Area (GMA), their ventures often have a fleeting lifespan, limiting their impact on global challenges. This research study, therefore, focuses on empowering these local …

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Establishing A Novel Lipid-Polyamine Metabolic Connection To Virus Replication, Yazmin Edith Cruz Pulido Dec 2023

Establishing A Novel Lipid-Polyamine Metabolic Connection To Virus Replication, Yazmin Edith Cruz Pulido

Dissertations

Polyamines are small positively charged alkylamines found in all living cells. These ubiquitous molecules have been found to play a variety of roles ranging from stabilizing nucleic acids (DNA and RNA) to cellular proliferation. Studies have also identified roles for polyamines in viral packaging and viral enzyme function. However, the role of polyamines on cellular components and their effect on viral replication is less known. In our efforts to identify the lipid-polyamine metabolic connection to virus replication we utilized a human hepatocyte cell line in which polyamines were depleted via pharmacological or genetic approaches and studied the effects on lipid …

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High-Fidelity Large-Diversity Monoclonal Mammalian Cell Libraries By Cell Cycle Arrested Recombinase-Mediated Cassette Exchange, Chuan Chen, Zening Wang, Minhyo Kang, Ki Baek Lee, Xin Ge Dec 2023

High-Fidelity Large-Diversity Monoclonal Mammalian Cell Libraries By Cell Cycle Arrested Recombinase-Mediated Cassette Exchange, Chuan Chen, Zening Wang, Minhyo Kang, Ki Baek Lee, Xin Ge

Faculty, Staff and Student Publications

Mammalian cells carrying defined genetic variations have shown great potentials in both fundamental research and therapeutic development. However, their full use was limited by lack of a robust method to construct large monoclonal high-quality combinatorial libraries. This study developed cell cycle arrested recombinase-mediated cassette exchange (aRMCE), able to provide monoclonality, precise genomic integration and uniform transgene expression. Via optimized nocodazole-mediated mitotic arrest, 20% target gene replacement efficiency was achieved without antibiotic selection, and the improved aRMCE efficiency was applicable to a variety of tested cell clones, transgene targets and transfection methods. As a demonstration of this versatile method, we performed …

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Metformin: A Potential Treatment For Acne, Hidradenitis Suppurativa And Rosacea, Minah Cho, Yu Ri Woo, Sang Hyun Cho, Jeong Deuk Lee, Hei Sung Kim Dec 2023

Metformin: A Potential Treatment For Acne, Hidradenitis Suppurativa And Rosacea, Minah Cho, Yu Ri Woo, Sang Hyun Cho, Jeong Deuk Lee, Hei Sung Kim

Faculty, Staff and Student Publications

Metformin is a widely used drug for treatment of diabetes mellitus, due to its safety and efficacy. In addition to its role as an antidiabetic drug, numerous beneficial effects of metformin have enabled its use in various diseases. Considering the anti-androgenic, anti-angiogenic, anti-fibrotic and antioxidant properties of metformin, it may have the potential to improve chronic inflammatory skin diseases. However, further evidence is needed to confirm the efficacy of metformin in dermatological conditions, This review focuses on exploring the therapeutic targets of metformin in acne vulgaris, hidradenitis suppurativa and rosacea, by studying their pathogeneses.

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Review Of "Reflections On The Names Of God: 180 Devotions To Know God More Fully", Cynthia Hammell Dec 2023

Review Of "Reflections On The Names Of God: 180 Devotions To Know God More Fully", Cynthia Hammell

The Christian Librarian

No abstract provided.

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Employment, Income, And Poverty In Kalamazoo City Core Neighborhoods, Val Klomparens Dec 2023

Employment, Income, And Poverty In Kalamazoo City Core Neighborhoods, Val Klomparens

Reports

This report employs a traditional methodology using American Community Survey data to examine employment, income, and poverty in three neighborhoods in Kalamazoo, Michigan: Eastside, Northside, and Edison. These neighborhoods are studied with an emphasis on eligibility status for the Distressed Area Recompete Pilot Program, administered through the U.S. Economic Development Administration. Eastside residents are unique in that a larger share earn income through wages or employment than do Michigan residents, yet their median income falls below those at the county and state levels in a statistically significant way. The Edison neighborhood is characterized by greater income inequality than the other …

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Response Differences Of Two Maize Hybrid Varieties To The Application Of Bioagent-Ameliorant And Chicken Manure In Fertile Soil, Endang Kantikowati, Karya, Yudi Yusdian, Dian Murti Minangsih, Tien Turmuktini, Erna Yuliani, Fija Faujiah Dec 2023

Response Differences Of Two Maize Hybrid Varieties To The Application Of Bioagent-Ameliorant And Chicken Manure In Fertile Soil, Endang Kantikowati, Karya, Yudi Yusdian, Dian Murti Minangsih, Tien Turmuktini, Erna Yuliani, Fija Faujiah

Jurnal Kultivasi

To ensure adequate nutrition for the growth of maize (Zea mays L.) in sustainable agriculture, it is necessary to apply bio-agent soil conditioner and manure. This study aims to determine the effect of doses of bioagent-ameliorant and chicken manure on growth and yield components. The research was conducted in highland with an altitude 800 m above sea level. This study used an experimental method with two sets of experiments, namely experiments using one and two-cobs maize cultivars. The experiment used a randomized block design (RBD) with two treatment factors and three replications. The first treatment factor was the dose of …

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Allelic Strengths Of Encephalopathy-Associated Uba5 Variants Correlate Between In Vivo And In Vitro Assays, Xueyang Pan, Albert N Alvarez, Mengqi Ma, Shenzhao Lu, Michael W Crawford, Lauren C Briere, Oguz Kanca, Shinya Yamamoto, David A Sweetser, Jenny L Wilson, Ruth J Napier, Jonathan N Pruneda, Hugo J Bellen Dec 2023

Allelic Strengths Of Encephalopathy-Associated Uba5 Variants Correlate Between In Vivo And In Vitro Assays, Xueyang Pan, Albert N Alvarez, Mengqi Ma, Shenzhao Lu, Michael W Crawford, Lauren C Briere, Oguz Kanca, Shinya Yamamoto, David A Sweetser, Jenny L Wilson, Ruth J Napier, Jonathan N Pruneda, Hugo J Bellen

Faculty, Staff and Students Publications

Protein UFMylation downstream of the E1 enzyme UBA5 plays essential roles in development and endoplasmic reticulum stress. Variants in the UBA5 gene are associated with developmental and epileptic encephalopathy 44 (DEE44), an autosomal recessive disorder characterized by early-onset encephalopathy, movement abnormalities, global developmental delay, intellectual disability, and seizures. DEE44 is caused by at least 12 different missense variants described as loss of function (LoF), but the relationships between genotypes and molecular or clinical phenotypes remain to be established. We developed a humanized UBA5 fly model and biochemical activity assays in order to describe in vivo and in vitro genotype–phenotype relationships …

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Information Communication Technology Competence And Reference Service Provision In Federal Universities In North-Central Nigeria., Ezinwanyi Madukoma, Catherine Enatta Ikokoh Dec 2023

Information Communication Technology Competence And Reference Service Provision In Federal Universities In North-Central Nigeria., Ezinwanyi Madukoma, Catherine Enatta Ikokoh

Library Philosophy and Practice (e-journal)

The study investigates information communication technology competence and reference service provision in Federal Universities in North-Central, Nigeria. Reference librarians now provide users with databases that give access to millions of journal articles as well as access to the internet which has holdings of libraries and a limitless variety of formal and informal sources of information. The study has one objective, a research question and one hypothesis. The study adopted total enumeration using a descriptive survey design. The population of the study is three hundred and sixty library personnel comprising professionals and para-professionals. Three hundred and six questionnaires were returned and …

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Engineering Exosomes To Specifically Target The Mitochondria Of Brain Cells, Xin Yan, Xinqian Chen, Zhiying Shan, Lanrong Bi Dec 2023

Engineering Exosomes To Specifically Target The Mitochondria Of Brain Cells, Xin Yan, Xinqian Chen, Zhiying Shan, Lanrong Bi

Michigan Tech Publications

Mitochondrial dysfunction is associated with various health conditions, including cardiovascular and neurodegenerative diseases. Mitochondrial-targeting therapy aims to restore or enhance mitochondrial function to treat or alleviate these conditions. Exosomes, small vesicles that cells secrete, containing a variety of biomolecules, are critical in cell-to-cell communication and have been studied as potential therapeutic agents. Exosome-based therapy has the potential to treat both cardiovascular and neurodegenerative diseases. Combining these two approaches involves using exosomes as carriers to transport mitochondrial-targeting agents to dysfunctional or damaged mitochondria within target cells. This article presents a new technique for engineering brain-derived exosomes that target mitochondria and has …

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"Sometimes Human Places Create Inhuman Monsters': An Examination Of The Monstrous And The Abject In American Literature, Carol Wardell Dec 2023

"Sometimes Human Places Create Inhuman Monsters': An Examination Of The Monstrous And The Abject In American Literature, Carol Wardell

Electronic Theses and Dissertations Archive

“‘Sometimes Human Places Create Inhuman Monsters’: An Examination of the Monstrous and the Abject in American Gothic Literature” defines “characters” in select texts as monstrous beings. These identified beings engage Julia Kristeva’s abject and differ from a grotesque. Whereas a grotesque character is often supportive in relation to the development of the story, the characters I have identified are crucial to the text. Without these characters and the abjection these monstrous beings evoke, the story would not develop in the same manner, have the same repercussions, nor have the same representation of cultural anxieties. In order to develop a definition …

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Dangerous John, J.W.M. Morgan Dec 2023

Dangerous John, J.W.M. Morgan

Valparaiso Fiction Review

No abstract provided.

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The Demons Of August, Wess Mongo Jolley Dec 2023

The Demons Of August, Wess Mongo Jolley

Valparaiso Fiction Review

No abstract provided.

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The Benefits Of Drama Therapy With Children And Adolescents, Rebecca Gallant Dec 2023

The Benefits Of Drama Therapy With Children And Adolescents, Rebecca Gallant

Honors Program Theses and Projects

Drama therapy, as defined by the North American Drama Therapy Association is “the intentional use of drama and/or theater processes to achieve therapeutic goals…an embodied practice that is active and experiential. This approach can provide the context for participants to tell their stories, set goals and solve problems, express feelings, or achieve catharsis” (NADTA 2021). NADTA was established in 1979 as an organization to advocate for drama therapy and to ensure that drama therapists are upholding the proper qualifications to practice. As noted by the organization, drama therapy can be used in a variety of different settings, including classrooms, nursing …

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Examining Steam Education Programs Within Art Museums: “A” Is For Art Museums, Kylie B. Corkern Dec 2023

Examining Steam Education Programs Within Art Museums: “A” Is For Art Museums, Kylie B. Corkern

Art 895 Research Papers

This case study considers the role that art museums can serve while using science, technology, engineering, arts, and math (STEAM) education. Through a qualitative inquiry, cases from literature are examined and opportunities are shared for best practices that art museums can use with STEAM education. This study not only advocates for art museums to include STEAM opportunities but also the collaboration between schools and art museums to be able to create these possibilities. Finding these concepts and ideas will show the unique position that art museums can play in STEAM education. This study will also share the influence in expanding …

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“An Exile They Gladly Embrace”: Queer Ecology In E.M. Forster’S Maurice, Bridget Medo Dec 2023

“An Exile They Gladly Embrace”: Queer Ecology In E.M. Forster’S Maurice, Bridget Medo

Theses

E.M. Forster’s novel Maurice, first written from 1913 to 1914 and published posthumously in 1971, is often noted for being the only one of Forster’s novels to feature an explicitly gay protagonist. This, as well as the fact that the novel has a happy ending, is what kept Forster from publishing it until after his death (Forster 250). According to Forster, Maurice “was the direct result of a visit to Edward Carpenter at Milthorpe [sic]” where Carpenter’s partner, George Merrill, touched Forster on the backside and apparently made a strong enough impression that Forster began writing Maurice right away (Forster …

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Habitar La Adamacidad: Contribuciones Desde Una Teología Feminista Queer, Mercy Aguilar Contreras Dec 2023

Habitar La Adamacidad: Contribuciones Desde Una Teología Feminista Queer, Mercy Aguilar Contreras

Conexión Queer: Revista Latinoamericana y Caribeña de Teologías Queer

Queer feminist theology emerges as a hybridization of corporeal experiences subjected to diverse mechanisms of control over life, body, and sexuality. This process of theologization questions the approach traditionally centered on cis- heteropatriarchal values, evidencing that classical theologies participate in the bio-technologies of reproduction of the body, gender, and sexuality. It highlights the historical influence of all theology in the construction of cis-heterocentered, patriarchalized and racialized bodies. The article proposes to (re)consider «adamacy» in order to rescue the difference of gender and sexuality present in sacred texts, thus liberating bodies from cis-heteronormative closets.

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Libertades Clandestinas: Hacia La Elaboración De Una Teología Queer Encarnacional, Marilú Rojas Salazar Dec 2023

Libertades Clandestinas: Hacia La Elaboración De Una Teología Queer Encarnacional, Marilú Rojas Salazar

Conexión Queer: Revista Latinoamericana y Caribeña de Teologías Queer

This article seeks to explore critical notions for developing a queer incarnational theology perspective. It begins by examining the concepts of «freedom» and «clandestinity» and then moves into the posthuman question, drawing on ecological feminism and queer/cuir theologies. In the final section, ideas are outlined that contribute to a queer incarnational theology, recovering the prophetic sense of the Gospel. This approach integrates freedom from a queer/ cuir perspective into a theological framework that resonates with human diversity and embraces the interconnectedness of all forms of life, challenging oppressive structures and recognizing the prophetic vitality of the Gospel.

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A Mathematical Model For Frogeye Leaf Spot Epidemics In Soybean, Chayu Yang, Jin Wang Dec 2023

A Mathematical Model For Frogeye Leaf Spot Epidemics In Soybean, Chayu Yang, Jin Wang

Department of Mathematics: Faculty Publications

We propose a new mathematical model based on differential equations to investigate the transmission and spread of frogeye leaf spot, a major soybean disease caused by the fungus Cercospora sojina. The model incorporates the primary and secondary transmission routes of the disease as well as the intrinsic dynamics of the pathogen in the contaminated soil. We conduct detailed equilibrium and stability analyses for this model using theories of dynamical systems. We additionally conduct numerical simulations to verify the analytical predictions and to implement the model for a practical application.

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Embracing Digital Mindsets To Ensure A Sustainable Future, Chengjun Li, Riqing Yu, Wenjing Ning, Huan Zhong, Christian Sonne Dec 2023

Embracing Digital Mindsets To Ensure A Sustainable Future, Chengjun Li, Riqing Yu, Wenjing Ning, Huan Zhong, Christian Sonne

Biology Faculty Publications and Presentations

The 19th Asian Games astounded global audiences with an opening spectacle that showcased stunning digital fireworks (International Olympic Committee, 2021; Zhe, 2023). The groundbreaking display was brought to life through virtual reality (VR) and augmented reality (AR) technologies. It sets a pioneering example to replace conventional fireworks in major international events as well as in other large-scale entertainment activities, marking a historic milestone in the pursuit of a sustainable and healthy future.

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