Digital Commons Network^™

Recombination-Mediated Dissemination Of Methicillin-Resistant S Aureus Clonal Complex 1 In The Egyptian Health Care Settings, Salma W Elsayed, Reem A Elghaish, Eman Badr, Shaimaa F Mouftah, Nehal A Saif, Iman S Naga, Ahmed H Shata, Ben Pascoe, Samuel K Sheppard, Mohamed Elhadidy

Faculty, Staff and Student Publications

Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a rapidly evolving pathogen that is frequently associated with outbreaks and sustained epidemics. This study investigated the population structure, resistome, virulome, and the correlation between antimicrobial resistance determinants with phenotypic resistance profiles of 36 representative hospital-acquired MRSA isolates recovered from hospital settings in Egypt.

Results: The community-acquired MRSA lineage, clonal complex 1 (CC1) was the most frequently detected clone, followed by three other globally disseminated clones, CC121, CC8, and CC22. Most isolates carried SCCmec type V and more than half of isolates demonstrated multi-drug resistant phenotypes. Resistance to linezolid, a last resort antibiotic for …

Apobec-1 Deletion Enhances Cisplatin-Induced Acute Kidney Injury, Xiaojia Guo, Valerie Blanc, Nicholas O Davidson, Heino Velazquez, Tian-Min Chen, Dennis G Moledina, Gilbert W Moeckel, Robert L Safirstein, Gary V Desir

2020-Current year OA Pubs

Cisplatin (CP) induces acute kidney injury (AKI) whereby proximal tubules undergo regulated necrosis. Repair is almost complete after a single dose. We now demonstrate a role for Apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 (Apobec-1) that is prominently expressed at the interface between acute and chronic kidney injury (CKD), in the recovery from AKI. Apobec-1 knockout (KO) mice exhibited greater mortality than in wild type (WT) and more severe AKI in both CP- and unilateral ischemia reperfusion (IR) with nephrectomy. Specifically, plasma creatinine (pCr) 2.6 ± 0.70 mg/dL for KO, n = 10 and 0.16 ± 0.02 for WT, …

Effect Of Different Levels Of Postbiotic And Phytobiotic Combination On Growth Performance, Economic Production, And Immune Response Of Broiler Chickens, Jamil Mobarak Mahmoud Doski, Karwan Yaseen Kareem

Polytechnic Journal

A total of two hundred and eighty eight day old unsexed chicks from a Ross 308 cross were randomly assigned to eight treatment and four replicates and each replicator had twelve birds. The experimental groups includes, N-control= negative control (basal diet), P-control = basal diet + 0.01% Doxin200 (positive control) (w/w), 0.1% Pos+Phy = basal diet + 0.05% thyme oil (v/w) + 0.05% postbiotic, 0.2% Pos+Phy = basal diet + 0.1% thyme oil (v/w) + 0.1% postbiotic, 0.3% Pos+Phy = basal diet + basal diet + 0.15% thyme oil (v/w) + 0.15% postbiotic, and 0.4% Pos+Phy = basal diet + …

Utilization Of Semiconductor Nanocrystals In Cancer Diagnose And Treatment, Yasir Q. Almajidi, Ahmed A. Albadri, Mazen M. Jwaid, Yaseen T. Khalaf

Maaen Journal for Medical Sciences

In contemporary times, nanotechnology has emerged as a notably sophisticated technological discipline. It possesses an interdisciplinary and multidisciplinary nature, spanning a wide array of domains including medical science, engineering, biology, physics, materials science, and chemistry. Utilization of nanotechnology offers a significant advantage by enabling precise manipulation and control of properties to effectively address specific challenges in various applications. In the fields of science and biomedicine, there has been extensive exploration into the use of functional nanomaterials, emerging as rapidly advancing and captivating areas of research. Diverse types of nanomaterials, including silicon nanowires, quantum dots, carbon nanotubes, and gold/silver nanoparticles, which …

Letter From The Editor In Chief, Jeffrey Lee

Transform

The TRANSFORM journal is a space for leaders, mentors, researchers, and practitioners of transformational leadership to be seen, heard, and valued; it is a place for making connections. Relationship-building is central to transformational leadership at all levels of an organization; this fundamental truth is a trending topic in literature. Otherwise, however, leadership can be an isolating experience.

As an ethnographer, I believe the best way to launch an academic, peer-reviewed journal is to do what I do best: storytelling. I want to share my thoughts on transformational leadership through a story in the form of a letter to my younger …

Sharp Stick Grasps At Autistic Women’S Liminal Vulnerability, Meaghan Krazinski

Ought: The Journal of Autistic Culture

This film analysis of Sharp Stick by Lena Dunham critically explores how the film uptakes representations of the ideas around the vulnerabilities of Autistic women in popular culture, and yet does not explicitly name them as such. This liminality is critical and plays into the intersectional analysis that the author engages around the way vulnerability and Autistic identity is interpreted and read. The author draws upon McDermott's (2022) "neurotypical gaze" in an analysis that shows how traditional tropes around Autistic women’s vulnerability are social constructions that are brought into relief by stereotypes around race, gender, and ability. The author uses …

Roman Food In The Imperial Age Viewed Through The Lens Of Class, John B. Nienhaus

The Exposition

A look into Roman food history in the imperial age with a focus on class and the differences of the classes eating habits, access to ingredients, and diets.

How Animal Assisted Therapy With Dogs Is Understood And Perceived Among Health Care Providers And The General Public In Canada, Healey Gardiner Dr., Jill Singleton-Jackson Dr.

Journal of Counseling and Psychology

When a dog is included in treatment to meet an individual’s therapeutic goal it is known as Animal-Assisted Therapy (AAT). Although AAT has increased in popularity, limited research exists regarding its efficacy. According to the diffusion of innovation theory an innovation must be properly communicated to all appropriate channels before it may be adopted into practice. Little is known about how AAT is understood and perceived among healthcare professional and public populations in Canada. In the present study, health care professionals and the general public in Canada were surveyed. Attitude toward dogs, openness to experience, agreeableness, and subjective distress were …

African American Students’ Academic And Web Programming Self-Efficacy, Learning Performance, And Perceptions Towards Computer Programming In Web Design Courses, Yu-Tung Kuo, Yu-Chun Kuo

College of Education Departmental Research

Computer programming has been included in computer literacy education in many countries in the last decade. This study examined the effects of gender and the prior programming experience of computer programming on academic and web programming self-efficacy and learning performance in the web design course among African American students, as well as their perceptions towards computer programming. This study’s 14-week web design course taught African American students multiple web programming languages, including HTML, CSS, and JavaScript, in order. A one-group pretest–posttest design was adopted in the experiment. The quantitative method was primarily used in data analysis. This study revealed that …

Critical Edition Of The Summe Of Christian Religion Delivered By Zacharias Ursinua, Taylor Trenta

University Honors Papers

Originally delivered by Zacharius Ursinus along with his work on the Heidelberg Catechism, The Summe of Christian Religion is an expansion on his contributions to the literature of Christian faith. The version, translated to English by Henry Parry, contributes to the depth of this reformed way of thinking across sixteenth to seventeenth century Western Europe; presented in the form of questions and explanations, this type of religious text is important for expanding on theological thoughts.

Gardner-Webb Campus Community Remembers Life Of Dr. Dianne Sykes, Office Of University Communications

Gardner-Webb NewsCenter Archive

The Gardner-Webb University campus community is remembering a friend, colleague and professor. Dr. Dianne Sykes, associate professor of sociology, passed away on Dec. 11, 2023.

Front Matter And Table Of Contents

University of Miami Inter-American Law Review

No abstract provided.

Unleashing The Beast: Confronting Animal Trafficking As Organized Crime In The Americas, Erick J. Wilson

University of Miami Inter-American Law Review

Wildlife trafficking is a serious yet often overlooked issue across the Americas. This Note examines wildlife trafficking across the Americas, analyzing the legal frameworks and challenges facing countries like the United States, Guatemala, Argentina, Peru, Mexico, and Brazil. Three key obstacles emerge: the lack of recognition of trafficking as organized crime, limited resources for enforcement, and deficient penalties. Though the United States has laws like the Lacey Act to address importation of illegally traded wildlife, weak foreign laws constrain efficacy. Many Latin American nations do not categorize wildlife trafficking as organized crime, despite its intricate parallels with activities like drug …

Oregon State Rank Assessment For Oregon Lakes Tui Chub (Siphateles Bicolor Oregonensis), Misty Nelson

Institute for Natural Resources Publications

Oregon state conservation status assessment for Oregon Lakes tui chub (Siphateles bicolor oregonensis) using NatureServe methodology, 2023.

Role Of Gonadotropin-Releasing Hormone 2 And Its Receptor In Human Reproductive Cancers, Dr. Amy T. Desaulniers, Brett White

School of Veterinary and Biomedical Sciences: Faculty Publications

Gonadotropin-releasing hormone (GnRH1) and its receptor (GnRHR1) drive reproduction by regulating gonadotropins. Another form, GnRH2, and its receptor (GnRHR2), also exist in mammals. In humans, GnRH2 and GnRHR2 genes are present, but coding errors in the GnRHR2 gene are predicted to hinder full-length protein production. Nonetheless, mounting evidence supports the presence of a functional GnRHR2 in humans. GnRH2 and its receptor have been identified throughout the body, including peripheral reproductive tissues like the ovary, uterus, breast, and prostate. In addition, GnRH2 and its receptor have been detected in a wide number of reproductive cancer cells in humans. Notably, GnRH2 analogues …

Oregon State Rank Assessment For Malheur Mottled Sculpin (Cottus Bendirei), Misty Nelson

Institute for Natural Resources Publications

Oregon state conservation status assessment for Malheur mottled sculpin (Cottus bendirei) using NatureServe methodology, 2023.

Oregon State Rank Assessment For Klamath Lake Sculpin (Cottus Princeps), Misty Nelson

Institute for Natural Resources Publications

Oregon state conservation status assessment for Klamath Lake sculpin (Cottus princeps) using NatureServe methodology, 2023.

Single-Nuclei Resolution Kidney Profiling In Physiological And Disease Settings, Ruiyang Liu

Arts & Sciences Graduate Student Theses and Dissertations

The kidney is a critical organ responsible for the maintenance of fluid, electrolyte and metabolites in the body. Recent advancements in kidney research, including the use of single-nuclei RNA Sequencing (snRNA-Seq), have uncovered a complex landscape that encompasses both physiological and pathological conditions. The scope of my thesis covers two important aspects: (1) the exploration of kidney sexual dimorphism, (2) a detailed investigation of polycystic kidney disease (PKD). To obtain a comprehensive understanding of the molecular regulation of kidney sexual dimorphism, we integrated single nucleus RNA and ATAC sequencing (snRNA-Seq and snATAC-Seq) and Visium spatial transcriptomics (ST) data to build …

The 2020 Revision Of The Puerto Rican Civil Code: A Brief Explanation Of Major Changes, Luis Muñiz-Argüelles

Journal of Civil Law Studies

Puerto Rico is with Louisiana one of the two United States jurisdictions having kept the civil law tradition as the bedrock of its private law. One of the last Spanish colonies, Puerto Rico became a US Territory in 1899. The Spanish Civil Code was replaced by a Puerto Rican Civil Code in 1930. A revision process spanned over a period of 23 years, ending with the adoption of a new Civil Code in 2020. After a presentation of the revision process, this report presents and discusses the changes and innovations in family law, property, contractual obligations, torts, and successions, also …

Judicial Methods Of Interpretation Of The Law (Excerpts), Julio C. Cueto-Rúa

Journal of Civil Law Studies

No abstract provided.

Oregon State Rank Assessment For Shorthead Sculpin (Cottus Confusus), Misty Nelson

Institute for Natural Resources Publications

Oregon state conservation status assessment for Shorthead sculpin (Cottus confusus) using NatureServe methodology, 2023.

Acculturation Stress And The Coping Skills Of African Immigrant Men In The United States, Emmanuel Oppong

Harold L. Hodgkinson Award for Outstanding Dissertation

African immigrant men living in the United States experience the process of acculturation and encounter varying stressors while adjusting to their new society. Despite the growing population of African immigrant men living in the United States, research on acculturative stress and coping excluded first-generation African immigrant men. The purpose of this descriptive phenomenological study was to examine the lived experiences of African immigrant men, the types of acculturative stress experienced, and the coping skills used in managing acculturative stress while living in the United States. Berry’s acculturation theory provided the framework for the study. Data were collected from 10 semistructured …

Ratflex: A Rom Device Used To Measure Post-Traumatic Joint Contracture In Rat Elbows, Ethan Riak

Mechanical Engineering and Materials Science Independent Study

During the fall 2023 semester, I worked in Dr. Lake’s musculoskeletal soft tissue lab. My main task was working on a device designed by previous students that is used to measure elbow range of motion in rats. The end goal of the device is to be able to detect differences in the range of motion between injured and uninjured rat elbows. The current protocol for comparing the range of motion of injured vs uninjured elbows requires that the rats be sacrificed and their elbows dissected for testing on a Biax machine. This device would allow for range of motion tests …

Self-Discrepancies In Mind Perception For Actual, Ideal, And Ought Selves And Partners, Oliver L. Jacobs, Farid Pazhoohi, Alan Kingstone

School of Psychology

Defining and measuring self-discrepancies in mind perception between how an individual sees their actual self in comparison to their ideal or ought self has a long but challenging history in psychology. Here we present a new approach for measuring and operationalizing discrepancies of mind by employing the mind perception framework that has been applied successfully to a variety of other psychological constructs. Across two studies (N = 265, N = 205), participants were recruited online to fill in a modified version of the mind perception survey with questions pertaining to three domains (actual, ideal, ought) and two agents (self versus …

Elovanoid-N34 Modulates Txnrd1 Key In Protection Against Oxidative Stress-Related Diseases, Jorgelina M. Calandria, Surjyadipta Bhattacharjee, Sayantani Kala-Bhattacharjee, Pranab K. Mukherjee, Yuehan Feng, Jakob Vowinckel, Tobias Treiber, Nicolas G. Bazan

School of Graduate Studies Faculty Publications

The thioredoxin (TXN) system is an NADPH + H+/FAD redox-triggered effector that sustains homeostasis, bioenergetics, detoxifying drug networks, and cell survival in oxidative stress-related diseases. Elovanoid (ELV)-N34 is an endogenously formed lipid mediator in neural cells from omega-3 fatty acid precursors that modulate neuroinflammation and senescence gene programming when reduction-oxidation (redox) homeostasis is disrupted, enhancing cell survival. Limited proteolysis (LiP) screening of human retinal pigment epithelial (RPE) cells identified TXNRD1 isoforms 2, 3, or 5, the reductase of the TXN system, as an intracellular target of ELV-N34. TXNRD1 silencing confirmed that the ELV-N34 target was isoform 2 or 3. This …

Oregon State Rank Assessment For Torrent Sculpin (Cottus Rhotheus), Misty Nelson

Institute for Natural Resources Publications

Oregon state conservation status assessment for torrent sculpin (Cottus rhotheus) using NatureServe methodology, 2023.

Acculturation Stress And The Coping Skills Of African Immigrant Men In The United States, Emmanuel Oppong

Walden Dissertations and Doctoral Studies

No abstract provided.

Identification Of Candidate Dna Methylation Biomarkers Related To Alzheimer’S Disease Risk By Integrating Genome And Blood Methylome Data, Yanfa Sun, Jingjing Zhu, Yaohua Yang, Zichen Zhang, Hua Zhong, Guanghua Zeng, Dan Zhou, Richard S Nowakowski, Jirong Long, Chong Wu, Lang Wu

Faculty, Staff and Student Publications

Alzheimer disease (AD) is a common neurodegenerative disease with a late onset. It is critical to identify novel blood-based DNA methylation biomarkers to better understand the extent of the molecular pathways affected in AD. Two sets of blood DNA methylation genetic prediction models developed using different reference panels and modelling strategies were leveraged to evaluate associations of genetically predicted DNA methylation levels with AD risk in 111,326 (46,828 proxy) cases and 677,663 controls. A total of 1,168 cytosine-phosphate-guanine (CpG) sites showed a significant association with AD risk at a false discovery rate (FDR) < 0.05. Methylation levels of 196 CpG sites were correlated with expression levels of 130 adjacent genes in blood. Overall, 52 CpG sites of 32 genes showed consistent association directions for the methylation-gene expression-AD risk, including nine genes (CNIH4, THUMPD3, SERPINB9, MTUS1, CISD1, FRAT2, CCDC88B, FES, and SSH2) firstly reported as AD risk genes. Nine of 32 genes were enriched in dementia and AD disease categories (P values ranged from 1.85 × 10-4 to 7.46 × 10-6), and 19 genes in a neurological disease network (score = 54) were also observed. Our findings improve the understanding of genetics and etiology for AD.

Neurodivergent Artists In Nyc, Brianna R. Poulos

Capstones

Workplaces, classrooms, and creative studios are just a few examples of everyday spaces that are largely designed with neurotypical norms in mind. Creating, sharing, and funding a creative vision is difficult for any artist, but these struggles are amplified for artists with intellectual disabilities who may have been overlooked or not given the same opportunities.

Over the last 18 months, journalist Brianna Rebecca Poulos has worked with neurodivergent artists in New York City and non-profits already working to serve this community of creatives. Brianna created a landing page to help neurodivergent artists in New York City access important information about …

Monitoring Glucocorticoid Receptor In Plasma-Derived Extracellular Vesicles As A Marker Of Resistance To Androgen Receptor Signaling Inhibition In Prostate Cancer, Emanuela Gentile, Andrew W Hahn, Jian H Song, Anh Hoang, Peter D A Shepherd, Sumankalai Ramachandran, Nora M Navone, Eleni Efstathiou, Mark Titus, Paul G Corn, Sue-Hwa Lin, Christopher J Logothetis, Theocharis Panaretakis

Faculty, Staff and Student Publications

Disease progression following androgen ablation was shown to be associated with upregulation of the glucocorticoid receptor (GR). Longitudinal monitoring of GR expression in circulating extracellular vesicles (EV) may reflect changes in the tumor cell and facilitates detection of acquired resistance. We utilized LNCaP, LREX cells and a patient-derived xenograft, MDA PDX 322-2-6a, for in vitro and in vivo experiments. Plasma-derived EVs were isolated from patients with localized high-risk prostate cancer undergoing androgen ablation. The mRNA levels of GR in EVs and their responsive genes were detected by transcriptome analysis, qRT-PCR and the protein levels by Western blot analysis. We detected …