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2022

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Goal-Oriented A-Posteriori Estimation Of Model Error As An Aid To Parameter Estimation, Prashant K. Jha, J. Tinsley Oden Dec 2022

Goal-Oriented A-Posteriori Estimation Of Model Error As An Aid To Parameter Estimation, Prashant K. Jha, J. Tinsley Oden

Faculty Publications

In this work, a Bayesian model calibration framework is presented that utilizes goal-oriented a-posterior error estimates in quantities of interest (QoIs) for classes of high-fidelity models characterized by PDEs. It is shown that for a large class of computational models, it is possible to develop a computationally inexpensive procedure for calibrating parameters of high-fidelity models of physical events when the parameters of low-fidelity (surrogate) models are known with acceptable accuracy. The main ingredients in the proposed model calibration scheme are goal-oriented a-posteriori estimates of error in QoIs computed using a so-called lower fidelity model compared to those of an uncalibrated …

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Genetic Dissection Of Alkalinity Tolerance At The Seedling Stage In Rice (Oryza Sativa) Using A High-Resolution Linkage Map, Lovepreet Singh, Sapphire Coronejo, Rajat Pruthi, Sandeep Chapagain, Uttam Bhattarai, Prasanta K. Subudhi Dec 2022

Genetic Dissection Of Alkalinity Tolerance At The Seedling Stage In Rice (Oryza Sativa) Using A High-Resolution Linkage Map, Lovepreet Singh, Sapphire Coronejo, Rajat Pruthi, Sandeep Chapagain, Uttam Bhattarai, Prasanta K. Subudhi

Faculty Publications

Although both salinity and alkalinity result from accumulation of soluble salts in soil, high pH and ionic imbalance make alkaline stress more harmful to plants. This study aimed to provide molecular insights into the alkalinity tolerance using a recombinant inbred line (RIL) population developed from a cross between Cocodrie and Dular with contrasting response to alkalinity stress. Forty-six additive QTLs for nine morpho-physiological traits were mapped on to a linkage map of 4679 SNPs under alkalinity stress at the seedling stage and seven major-effect QTLs were for alkalinity tolerance scoring, Na+ and K+ concentrations and Na+:K+ ratio. The candidate genes …

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The 2018 World Cancer Research Fund (Wcrf)/American Institute For Cancer Research (Aicr) Score And Diabetes Risk In The Diabetes Prevention Program Outcomes Study (Dppos), Marissa M. Shams-White, Ashley H. Tjaden, Sharon L. Edelstein, Sarah Bassiouni, Lisa L. Kahle, Catherine Kim, Xavier Pi-Sunyer, Karla A. Temple, Elizabeth M. Venditti, Jill Reedy, Brandy M. Heckman-Stoddard, George A. Bray, Kishore M. Gadde, Iris W. Culbert, Jennifer Arceneaux, Annie Chatellier, Amber Dragg, Catherine M. Champagne, Crystal Duncan, Barbara Eberhardt, Frank Greenway, Fonda G. Guillory, April A. Herbert, Michael L. Jeffirs, Betty M. Kennedy, Erma Levy, Monica Lockett, Jennifer C. Lovejoy, Laura H. Morris, Lee E. Melancon, Donna H. Ryan, Deborah A. Sanford, Kenneth G. Smith, Lisa L. Smith Dec 2022

The 2018 World Cancer Research Fund (Wcrf)/American Institute For Cancer Research (Aicr) Score And Diabetes Risk In The Diabetes Prevention Program Outcomes Study (Dppos), Marissa M. Shams-White, Ashley H. Tjaden, Sharon L. Edelstein, Sarah Bassiouni, Lisa L. Kahle, Catherine Kim, Xavier Pi-Sunyer, Karla A. Temple, Elizabeth M. Venditti, Jill Reedy, Brandy M. Heckman-Stoddard, George A. Bray, Kishore M. Gadde, Iris W. Culbert, Jennifer Arceneaux, Annie Chatellier, Amber Dragg, Catherine M. Champagne, Crystal Duncan, Barbara Eberhardt, Frank Greenway, Fonda G. Guillory, April A. Herbert, Michael L. Jeffirs, Betty M. Kennedy, Erma Levy, Monica Lockett, Jennifer C. Lovejoy, Laura H. Morris, Lee E. Melancon, Donna H. Ryan, Deborah A. Sanford, Kenneth G. Smith, Lisa L. Smith

Population and Public Health Science Faculty Publications

Background: The 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) 3rd expert report highlights up-to-date Cancer Prevention Recommendations that may reduce burdens of many chronic diseases, including diabetes. This study examined if following a lifestyle that aligns with the recommendations – assessed via the 2018 WCRF/AICR Score – was associated with lower risk of type 2 diabetes in high-risk adults participating in the Diabetes Prevention Program Outcomes Study (DPPOS). Methods: The Diabetes Prevention Program (DPP) randomized adults at high risk for diabetes to receive a lifestyle intervention (ILS), metformin (MET) or a placebo (PLB) (mean: 3.2 years), with …

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Correlates Of The Physical Activity Decline During Childhood, Sara Pereira, Ana Carolina Reyes, Raquel Chaves, Carla Santos, Olga Vasconcelos, G. O. Tani, Peter T. Katzmarzyk, Adam Baxter-Jones, José Maia Dec 2022

Correlates Of The Physical Activity Decline During Childhood, Sara Pereira, Ana Carolina Reyes, Raquel Chaves, Carla Santos, Olga Vasconcelos, G. O. Tani, Peter T. Katzmarzyk, Adam Baxter-Jones, José Maia

Population and Public Health Science Faculty Publications

Purpose This study aimed to describe longitudinal trends in children's moderate-to-vigorous physical activity (MVPA) and to investigate associations with individual, familial, and school characteristics. Methods A sample of 341 Portuguese children age 5-10 yr (173 girls) from six age cohorts was followed over 3 yr using a mixed-longitudinal design. Physical activity, body mass index (BMI), gross motor coordination, and musculoskeletal fitness were assessed annually. Information on socioeconomic status and school characteristics was collected and analyzed with mixed models. Results MVPA shows a similar declining trend in both sexes, but on average, boys exceeded the World Health Organization recommendations of 60 …

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A Collaborative Approach To Adopting/Adapting Guidelines. The Australian 24-Hour Movement Guidelines For Children (5-12 Years) And Young People (13-17 Years): An Integration Of Physical Activity, Sedentary Behaviour, And Sleep, Anthony D. Okely, Davina Ghersi, Sarah P. Loughran, Dylan P. Cliff, Trevor Shilton, Rachel A. Jones, Rebecca M. Stanley, Julie Sherring, Natalie Toms, Simon Eckermann, Timothy S. Olds, Zhiguang Zhang, Anne Maree Parrish, Lisa Kervin, Sandra Downie, Jo Salmon, Clair Bannerman, Tamie Needham, Elaine Marshall, Jordy Kaufman, Layne Brown, Janecke Wille, Greg Wood, David R. Lubans, Stuart J.H. Biddle, Shane Pill, Anthea Hargreaves, Natalie Jonas, Natasha Schranz, Perry Campbell, Karen Ingram, Hayley Dean, Adam Verrender, Yvonne Ellis Dec 2022

A Collaborative Approach To Adopting/Adapting Guidelines. The Australian 24-Hour Movement Guidelines For Children (5-12 Years) And Young People (13-17 Years): An Integration Of Physical Activity, Sedentary Behaviour, And Sleep, Anthony D. Okely, Davina Ghersi, Sarah P. Loughran, Dylan P. Cliff, Trevor Shilton, Rachel A. Jones, Rebecca M. Stanley, Julie Sherring, Natalie Toms, Simon Eckermann, Timothy S. Olds, Zhiguang Zhang, Anne Maree Parrish, Lisa Kervin, Sandra Downie, Jo Salmon, Clair Bannerman, Tamie Needham, Elaine Marshall, Jordy Kaufman, Layne Brown, Janecke Wille, Greg Wood, David R. Lubans, Stuart J.H. Biddle, Shane Pill, Anthea Hargreaves, Natalie Jonas, Natasha Schranz, Perry Campbell, Karen Ingram, Hayley Dean, Adam Verrender, Yvonne Ellis

Population and Public Health Science Faculty Publications

Abstract: Background: In 2018, the Australian Government updated the Australian Physical Activity and Sedentary Behaviour Guidelines for Children and Young People. A requirement of this update was the incorporation of a 24-hour approach to movement, recognising the importance of adequate sleep. The purpose of this paper was to describe how the updated Australian 24-Hour Movement Guidelines for Children and Young People (5 to 17 years): an integration of physical activity, sedentary behaviour and sleep were developed and the outcomes from this process. Methods: The GRADE-ADOLOPMENT approach was used to develop the guidelines. A Leadership Group was formed, who identified existing …

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Author Correction: Novel Mode Of Defective Neural Tube Closure In The Non-Obese Diabetic (Nod) Mouse Strain (Scientific Reports, (2015), 5, 1, (16917), 10.1038/Srep16917), J. Michael Salbaum, Claudia Kruger, Jacalyn Macgowan, Nils J. Herion, David Burk, Claudia Kappen Dec 2022

Author Correction: Novel Mode Of Defective Neural Tube Closure In The Non-Obese Diabetic (Nod) Mouse Strain (Scientific Reports, (2015), 5, 1, (16917), 10.1038/Srep16917), J. Michael Salbaum, Claudia Kruger, Jacalyn Macgowan, Nils J. Herion, David Burk, Claudia Kappen

Division of Basic Science Faculty Publications

The Supplementary Information file published with this Article is incomplete, where the supplementary figures and tables are omitted. The correct Supplementary Information file is now linked to this correction notice.

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Low-Energy Dense Potato- And Bean-Based Diets Reduce Body Weight And Insulin Resistance: A Randomized, Feeding, Equivalence Trial, Candida J. Rebello, Robbie A. Beyl, Frank L. Greenway, Kelly C. Atteberry, Kristin K. Hoddy, John P. Kirwan Dec 2022

Low-Energy Dense Potato- And Bean-Based Diets Reduce Body Weight And Insulin Resistance: A Randomized, Feeding, Equivalence Trial, Candida J. Rebello, Robbie A. Beyl, Frank L. Greenway, Kelly C. Atteberry, Kristin K. Hoddy, John P. Kirwan

Division of Basic Science Faculty Publications

We evaluated the effect of diets low in energy density (1 kcal/g) and high in either potatoes (Potato) or pulses (Bean) on blood glucose control in participants with insulin resistance. We hypothesized that the Potato and Bean diets would have equivalent effects. This was an 8-week randomized, parallel design, controlled feeding study comparing Potato and Bean diets (50-55% carbohydrate, 30-35% fat, 15-20% protein). Equivalence was prespecified as the mean change in the blood glucose concentration for Potato that was within ±20% of the Bean diet. Thirty-six participants (age: 18-60 years, body mass index: 25-40 kg/m2) with insulin resistance (homeostatic model …

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Blocking Actriib And Restoring Appetite Reverses Cachexia And Improves Survival In Mice With Lung Cancer, Andre Lima Queiroz, Ezequiel Dantas, Shakti Ramsamooj, Anirudh Murthy, Mujmmail Ahmed, Elizabeth R.M. Zunica, Roger J. Liang, Jessica Murphy, Corey D. Holman, Curtis J. Bare, Gregory Ghahramani, Zhidan Wu, David E. Cohen, John P. Kirwan, Lewis C. Cantley, Christopher L. Axelrod, Marcus D. Goncalves Dec 2022

Blocking Actriib And Restoring Appetite Reverses Cachexia And Improves Survival In Mice With Lung Cancer, Andre Lima Queiroz, Ezequiel Dantas, Shakti Ramsamooj, Anirudh Murthy, Mujmmail Ahmed, Elizabeth R.M. Zunica, Roger J. Liang, Jessica Murphy, Corey D. Holman, Curtis J. Bare, Gregory Ghahramani, Zhidan Wu, David E. Cohen, John P. Kirwan, Lewis C. Cantley, Christopher L. Axelrod, Marcus D. Goncalves

Division of Basic Science Faculty Publications

Cancer cachexia is a common, debilitating condition with limited therapeutic options. Using an established mouse model of lung cancer, we find that cachexia is characterized by reduced food intake, spontaneous activity, and energy expenditure accompanied by muscle metabolic dysfunction and atrophy. We identify Activin A as a purported driver of cachexia and treat with ActRIIB-Fc, a decoy ligand for TGF-β/activin family members, together with anamorelin (Ana), a ghrelin receptor agonist, to reverse muscle dysfunction and anorexia, respectively. Ana effectively increases food intake but only the combination of drugs increases lean mass, restores spontaneous activity, and improves overall survival. These beneficial …

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Predicting Energy Intake In Adults Who Are Dieting And Exercising, Corey Gerving, Robert Lasater, James Starling, Danielle M. Ostendorf, Leanne M. Redman, Chad Estabrooks, Kevin Cummiskey, Vincent Antonetti, Diana M. Thomas Dec 2022

Predicting Energy Intake In Adults Who Are Dieting And Exercising, Corey Gerving, Robert Lasater, James Starling, Danielle M. Ostendorf, Leanne M. Redman, Chad Estabrooks, Kevin Cummiskey, Vincent Antonetti, Diana M. Thomas

Clinical Research Faculty Publications

Background: When a lifestyle intervention combines caloric restriction and increased physical activity energy expenditure (PAEE), there are two components of energy balance, energy intake (EI) and physical activity energy expenditure (PAEE), that are routinely misreported and expensive to measure. Energy balance models have successfully predicted EI if PAEE is known. Estimating EI from an energy balance model when PAEE is not known remains an open question. Objective: The objective was to evaluate the performance of an energy balance differential equation model to predict EI in an intervention that includes both calorie restriction and increases in PAEE. Design: The Antonetti energy …

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Beyond The Unknown: A Broad Framing For Preparedness For Emerging Infectious Threats, Rebecca C. Christofferson, Stephania A. Cormier Dec 2022

Beyond The Unknown: A Broad Framing For Preparedness For Emerging Infectious Threats, Rebecca C. Christofferson, Stephania A. Cormier

Division of Basic Science Faculty Publications

There have been multiple instances of novel pathogen emergence that have affected the health and security of the global community. To highlight that these novel pathogens presented a clear danger to public health, the WHO included “Disease X” on their list of priority pathogens in 2018. Indeed, since the emergence of SARS-CoV-2, Disease X has been pointed to as the looming threat of “the next big thing.” However, developing surveillance and preparedness plans with Disease X as the linchpin is too narrow and ignores a large swath of potential threats from already identified, often neglected diseases. We propose instead the …

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Multidisciplinary Collaboration To Develop A Digital Health Solution For Early Detection Of Cognitive Decline In Primary Care, Robin C. Hilsabeck, Jeffrey N. Keller, Maya L. Henry, Paul Toprac, Paul Rathouz, Varshinee Sreekanth, Avery Largent, Joshua Chang, Jessy Li, Lokesh Pugalenthi, Thomas Parsons, Heather E. Cuevas, Suzanne Schmitz Dec 2022

Multidisciplinary Collaboration To Develop A Digital Health Solution For Early Detection Of Cognitive Decline In Primary Care, Robin C. Hilsabeck, Jeffrey N. Keller, Maya L. Henry, Paul Toprac, Paul Rathouz, Varshinee Sreekanth, Avery Largent, Joshua Chang, Jessy Li, Lokesh Pugalenthi, Thomas Parsons, Heather E. Cuevas, Suzanne Schmitz

Clinical Research Faculty Publications

Background: Developing digital healthcare solutions that facilitate rapid identification and effective management of patients with Alzheimer disease and related disorders (ADRD) is an area of intense study. A critical juncture for these efforts involves the early detection of cognitive decline. Because primary care providers (PCPs) are the first line of medical care, they are often the first to hear concerns about cognitive decline. However, under-diagnosis of ADRD in primary care settings is widely recognized, as are the many barriers to routine cognitive screening. While information about brief cognitive screening tools for detecting ADRD is plentiful, PCPs remain uncertain about which …

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The Trend Of Disruption In The Functional Brain Network Topology Of Alzheimer’S Disease, Alireza Fathian, Yousef Jamali, Mohammad Reza Raoufy, Michael W. Weiner, Norbert Schuf, Howard J. Rosen, Bruce L. Miller, Thomas Neylan, Jacqueline Hayes, Shannon Finley, Paul Aisen, Zaven Khachaturian, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Leon Thal, James Brewer, Helen Vanderswag, Adam Fleisher, Melissa Davis, Rosemary Morrison, Ronald Petersen, Cliford R. Jack, Matthew Bernstein, Bret Borowski, Jef Gunter, Matt Senjem, Prashanthi Vemuri, David Jones, Kejal Kantarci, Chad Ward Dec 2022

The Trend Of Disruption In The Functional Brain Network Topology Of Alzheimer’S Disease, Alireza Fathian, Yousef Jamali, Mohammad Reza Raoufy, Michael W. Weiner, Norbert Schuf, Howard J. Rosen, Bruce L. Miller, Thomas Neylan, Jacqueline Hayes, Shannon Finley, Paul Aisen, Zaven Khachaturian, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Leon Thal, James Brewer, Helen Vanderswag, Adam Fleisher, Melissa Davis, Rosemary Morrison, Ronald Petersen, Cliford R. Jack, Matthew Bernstein, Bret Borowski, Jef Gunter, Matt Senjem, Prashanthi Vemuri, David Jones, Kejal Kantarci, Chad Ward

Clinical Research Faculty Publications

Alzheimer’s disease (AD) is a progressive disorder associated with cognitive dysfunction that alters the brain’s functional connectivity. Assessing these alterations has become a topic of increasing interest. However, a few studies have examined different stages of AD from a complex network perspective that cover different topological scales. This study used resting state fMRI data to analyze the trend of functional connectivity alterations from a cognitively normal (CN) state through early and late mild cognitive impairment (EMCI and LMCI) and to Alzheimer’s disease. The analyses had been done at the local (hubs and activated links and areas), meso (clustering, assortativity, and …

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Effect Of Renin-Angiotensin System Antihypertensive Medication Use On Cognitive Function In Diabetes Mellitus With Obesity Or Overweight: An Ancillary Study To The Action For Health In Diabetes (Look Ahead) Trial, Whitney Wharton, Andrea Anderson, Kathleen M. Hayden, Owen T. Carmichael, Jeanne M. Clark, José A. Luchsinger, Mark Espeland, Sevil Yasar Dec 2022

Effect Of Renin-Angiotensin System Antihypertensive Medication Use On Cognitive Function In Diabetes Mellitus With Obesity Or Overweight: An Ancillary Study To The Action For Health In Diabetes (Look Ahead) Trial, Whitney Wharton, Andrea Anderson, Kathleen M. Hayden, Owen T. Carmichael, Jeanne M. Clark, José A. Luchsinger, Mark Espeland, Sevil Yasar

Clinical Research Faculty Publications

Aim: To determine whether antihypertensive medication (AHM) acting through the renin angiotensin system (RAS-AHM), compared with other AHM, can mitigate effects on cognitive function and risk for impairment in a population with type 2 diabetes mellitus (T2DM). Materials and Methods: This secondary analysis of the randomized controlled Action for Health in Diabetes (Look AHEAD) study included 712 community-dwelling participants who were followed over 15 years. Logistic regression was used to relate RAS-AHM use to cognitive impairment, and linear regression was used to relate RAS-AHM use to domain-specific cognitive function after adjusting for potential confounders. Results: A total of 563 individuals …

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Dissociation Of Tau Pathology And Neuronal Hypometabolism Within The Atn Framework Of Alzheimer’S Disease, Michael Tran Duong, Sandhitsu R. Das, Xueying Lyu, Long Xie, Hayley Richardson, Sharon X. Xie, Paul A. Yushkevich, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John C. Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gustavo Jimenez-Maggiora, Danielle Harvey, Matthew Bernstein, Nick Fox, Paul Thompson, Norbert Schuff, Charles Decarli, Bret Borowski Dec 2022

Dissociation Of Tau Pathology And Neuronal Hypometabolism Within The Atn Framework Of Alzheimer’S Disease, Michael Tran Duong, Sandhitsu R. Das, Xueying Lyu, Long Xie, Hayley Richardson, Sharon X. Xie, Paul A. Yushkevich, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John C. Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gustavo Jimenez-Maggiora, Danielle Harvey, Matthew Bernstein, Nick Fox, Paul Thompson, Norbert Schuff, Charles Decarli, Bret Borowski

Clinical Research Faculty Publications

Alzheimer’s disease (AD) is defined by amyloid (A) and tau (T) pathologies, with T better correlated to neurodegeneration (N). However, T and N have complex regional relationships in part related to non-AD factors that influence N. With machine learning, we assessed heterogeneity in 18F-flortaucipir vs. 18F-fluorodeoxyglucose positron emission tomography as markers of T and neuronal hypometabolism (NM) in 289 symptomatic patients from the Alzheimer’s Disease Neuroimaging Initiative. We identified six T/NM clusters with differing limbic and cortical patterns. The canonical group was defined as the T/NM pattern with lowest regression residuals. Groups resilient to T had less hypometabolism than expected …

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Author Correction: Fam222a Encodes A Protein Which Accumulates In Plaques In Alzheimer’S Disease (Nature Communications, (2020), 11, 1, (411), 10.1038/S41467-019-13962-0), Tingxiang Yan, Jingjing Liang, Ju Gao, Luwen Wang, Hisashi Fujioka, Michael W. Weiner, Norbert Schuff, Howard J. Rosen, Bruce L. Miller, David Perry, Paul Aisen, Paul Aisen, Arthur W. Toga, Gustavo Jimenez, Michael Donohue, Devon Gessert, Kelly Harless, Jennifer Salazar, Yuliana Cabrera, Sarah Walter, Lindsey Hergesheimer, Karen Crawford, Scott Neu, Lon S. Schneider, Sonia Pawluczyk, Mauricio Becerra, Liberty Teodoro, Bryan M. Spann, Ronald Petersen, Clifford R. Jack, Matthew Bernstein, Bret Borowski, Jeff Gunter, Matt Senjem Dec 2022

Author Correction: Fam222a Encodes A Protein Which Accumulates In Plaques In Alzheimer’S Disease (Nature Communications, (2020), 11, 1, (411), 10.1038/S41467-019-13962-0), Tingxiang Yan, Jingjing Liang, Ju Gao, Luwen Wang, Hisashi Fujioka, Michael W. Weiner, Norbert Schuff, Howard J. Rosen, Bruce L. Miller, David Perry, Paul Aisen, Paul Aisen, Arthur W. Toga, Gustavo Jimenez, Michael Donohue, Devon Gessert, Kelly Harless, Jennifer Salazar, Yuliana Cabrera, Sarah Walter, Lindsey Hergesheimer, Karen Crawford, Scott Neu, Lon S. Schneider, Sonia Pawluczyk, Mauricio Becerra, Liberty Teodoro, Bryan M. Spann, Ronald Petersen, Clifford R. Jack, Matthew Bernstein, Bret Borowski, Jeff Gunter, Matt Senjem

Clinical Research Faculty Publications

In the original version of the manuscript, the image shown in Figure 4g, bottom row (Aβ1–42 + rAggregatin), under “6h” was incorrect. This image incorrectly showed the same sample as shown in the original Figure 4g, top row (Aβ1–42), under “0.5h”. The correct version of figure 4g is as follows: (Figure presented.) which replaces the previous incorrect version: (Figure presented.).

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Uterine Lumen Fluid Is Metabolically Semi-Autonomous, Constantine A. Simintiras, Jessica N. Drum, Hongyu Liu, M. Sofia Ortega, Thomas E. Spencer Dec 2022

Uterine Lumen Fluid Is Metabolically Semi-Autonomous, Constantine A. Simintiras, Jessica N. Drum, Hongyu Liu, M. Sofia Ortega, Thomas E. Spencer

Faculty Publications

Uterine lumen fluid (ULF) is central to successful pregnancy establishment and maintenance, and impacts offspring wellbeing into adulthood. The current dogma is that ULF composition is primarily governed by endometrial glandular epithelial cell secretions and influenced by progesterone. To investigate the hypothesis that ULF is metabolically semi-autonomous, ULF was obtained from cyclic heifers, and aliquots incubated for various durations prior to analysis by untargeted semi-quantitative metabolomic profiling. Metabolite flux was observed in these ULF isolates, supporting the idea that the biochemical makeup of ULF is semi-autonomously dynamic due to enzyme activities. Subsequent integrative analyses of these, and existing, data predict …

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Non-Destructive Quality Evaluation Of Tropical Fruit (Mango And Mangosteen) Purée Using Near-Infrared Spectroscopy Combined With Partial Least Squares Regression, Pimpen Pornchaloempong, Sneha Sharma, Thitima Phanomsophon, Kraisuwit Srisawat, Wasan Inta, Panmanas Sirisomboon, Witoon Prinyawiwatkul, Natrapee Nakawajana, Ravipat Lapcharoensuk, Sontisuk Teerachaichayut Dec 2022

Non-Destructive Quality Evaluation Of Tropical Fruit (Mango And Mangosteen) Purée Using Near-Infrared Spectroscopy Combined With Partial Least Squares Regression, Pimpen Pornchaloempong, Sneha Sharma, Thitima Phanomsophon, Kraisuwit Srisawat, Wasan Inta, Panmanas Sirisomboon, Witoon Prinyawiwatkul, Natrapee Nakawajana, Ravipat Lapcharoensuk, Sontisuk Teerachaichayut

Faculty Publications

Mango and mangosteen are commercially important tropical fruits with a short shelf life. Fruit processing is one of the alternatives to extend the shelf life of these fruits. Purée is one of the processed products of fresh fruit. In this research, the quality of mango and mangosteen purée was analyzed. Titratable acidity (TA) and total soluble solids (TSS) were predicted using non-destructive near-infrared (NIR) spectroscopy. A partial least squares regression (PLSR) model was developed based on the NIR spectra with a wavelength ranging from 800 to 2500 nm. The PLSR model returned a coefficient of determination (r2) and a ratio …

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Characterization Of A Stress-Enhanced Promoter From The Grass Halophyte, Spartina Alterniflora L., Sonali Sengupta, Necla Pehlivan, Venkata Mangu, Kanniah Rajasekaran, Niranjan Baisakh Dec 2022

Characterization Of A Stress-Enhanced Promoter From The Grass Halophyte, Spartina Alterniflora L., Sonali Sengupta, Necla Pehlivan, Venkata Mangu, Kanniah Rajasekaran, Niranjan Baisakh

Faculty Publications

Stress-inducible promoters are vital for the desirable expression of genes, especially transcription factors, which could otherwise compromise growth and development when constitutively overexpressed in plants. Here, we report on the characterization of the promoter region of a stress-responsive gene SaAsr1 from monocot halophyte cordgrass (Spartina alterniflora). Several cis-acting elements, such as ABRE (ABA-responsive element), DRE-CRT (dehydration responsive-element/C-Repeat), LTRE (low temperature-responsive element), ERE (ethylene-responsive element), LRE (light-responsive element), etc. contributed at varying degrees to salt-, drought- and ABA-enhanced expression of gusA reporter gene in Arabidopsis thaliana under the full-length promoter, pAsr11875 and its deletion derivatives with an assortment of cis-regulatory motifs. …

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Improving Customer Satisfaction For Smes In Emerging Countries: A Comparative Study Of Hungary And Indonesia, Santi Setyaningsih, Peter Kelle Dec 2022

Improving Customer Satisfaction For Smes In Emerging Countries: A Comparative Study Of Hungary And Indonesia, Santi Setyaningsih, Peter Kelle

Faculty Publications

Improving Customer Satisfaction (CS) is a key strategical goal for companies, especially for Small and Medium-Sized Enterprises (SMEs). The objective of this research is to find and rank the major factors supporting CS. We focus on SMEs in two emerging markets located in two countries with different geographical and supply chain environments. We test a conceptual framework that includes several factors supporting CS. The data were collected from Hungarian and Indonesian SMEs by online questionnaire. We used statistical analysis such as Exploratory Factor Analysis (EFA), Confirmatory Factor Analysis (CFA), and Structural Equation Model (SEM) to test our model and hypothesis. …

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Angles Between Subspaces And Nearly Optimal Approximation In Gfem, Robert Lipton, Paul Sinz, Michael Stuebner Dec 2022

Angles Between Subspaces And Nearly Optimal Approximation In Gfem, Robert Lipton, Paul Sinz, Michael Stuebner

Faculty Publications

The Generalized Finite Element Methods (GFEM) are known for accurately resolving local features in heterogeneous media. Recent numerical experiments have shown that the use of local bases made from A-harmonic extensions of well chosen boundary data have nearly optimal approximation properties. In this paper we show that the explanation is geometric and given by the angle between any finite dimensional approximation space and the optimal finite dimensional approximation space introduced in (Babǔska and Lipton, 2011). The effect of the angle is quantified by an upper bound on the convergence rate. This rate is seen in the numerical simulations where local …

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Nuclear Forces For Precision Nuclear Physics: A Collection Of Perspectives, Ingo Tews, Zohreh Davoudi, Andreas Ekström, Jason D. Holt, Kevin Becker, Raúl Briceño, David J. Dean, William Detmold, Christian Drischler, Thomas Duguet, Evgeny Epelbaum, Ashot Gasparyan, Jambul Gegelia, Jeremy R. Green, Harald W. Grießhammer, Andrew D. Hanlon, Matthias Heinz, Heiko Hergert, Martin Hoferichter, Marc Illa, David Kekejian, Alejandro Kievsky, Sebastian König, Hermann Krebs, Kristina D. Launey, Dean Lee, Petr Navrátil, Amy Nicholson, Assumpta Parreño, Daniel R. Phillips, Marek Płoszajczak, Xiu Lei Ren, Thomas R. Richardson Dec 2022

Nuclear Forces For Precision Nuclear Physics: A Collection Of Perspectives, Ingo Tews, Zohreh Davoudi, Andreas Ekström, Jason D. Holt, Kevin Becker, Raúl Briceño, David J. Dean, William Detmold, Christian Drischler, Thomas Duguet, Evgeny Epelbaum, Ashot Gasparyan, Jambul Gegelia, Jeremy R. Green, Harald W. Grießhammer, Andrew D. Hanlon, Matthias Heinz, Heiko Hergert, Martin Hoferichter, Marc Illa, David Kekejian, Alejandro Kievsky, Sebastian König, Hermann Krebs, Kristina D. Launey, Dean Lee, Petr Navrátil, Amy Nicholson, Assumpta Parreño, Daniel R. Phillips, Marek Płoszajczak, Xiu Lei Ren, Thomas R. Richardson

Faculty Publications

This is a collection of perspective pieces contributed by the participants of the Institute for Nuclear Theory’s Program on Nuclear Physics for Precision Nuclear Physics which was held virtually from April 19 to May 7, 2021. The collection represents the reflections of a vibrant and engaged community of researchers on the status of theoretical research in low-energy nuclear physics, the challenges ahead, and new ideas and strategies to make progress in nuclear structure and reaction physics, effective field theory, lattice QCD, quantum information, and quantum computing. The contributed pieces solely reflect the perspectives of the respective authors and do not …

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Smart Quantum Statistical Imaging Beyond The Abbe-Rayleigh Criterion, Narayan Bhusal, Mingyuan Hong, Ashe Miller, Mario A. Quiroz-Juárez, Roberto De J. León-Montiel, Chenglong You, Omar S. Magaña-Loaiza Dec 2022

Smart Quantum Statistical Imaging Beyond The Abbe-Rayleigh Criterion, Narayan Bhusal, Mingyuan Hong, Ashe Miller, Mario A. Quiroz-Juárez, Roberto De J. León-Montiel, Chenglong You, Omar S. Magaña-Loaiza

Faculty Publications

The wave nature of light imposes limits on the resolution of optical imaging systems. For over a century, the Abbe-Rayleigh criterion has been utilized to assess the spatial resolution limits of imaging instruments. Recently, there has been interest in using spatial projective measurements to enhance the resolution of imaging systems. Unfortunately, these schemes require a priori information regarding the coherence properties of “unknown” light beams and impose stringent alignment conditions. Here, we introduce a smart quantum camera for superresolving imaging that exploits the self-learning features of artificial intelligence to identify the statistical fluctuations of unknown mixtures of light sources at …

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The Rotor-Vibrator Plus Multi-Particle-Hole Description Of 154gd, Yingxin Wu, Aoxue Li, Feng Pan, Lianrong Dai, Jerry P. Draayer Dec 2022

The Rotor-Vibrator Plus Multi-Particle-Hole Description Of 154gd, Yingxin Wu, Aoxue Li, Feng Pan, Lianrong Dai, Jerry P. Draayer

Faculty Publications

Based on the well-known rotor-vibrator model and the particle-plus-rotor model, multi-particle-hole excitations from a collective even-even core described by the rotor-vibrator is considered to describe well-deformed even-even nuclei. Like the particle-plus-rotor model, the intrinsic Vierergruppe (D2) symmetry is still preserved in the rotor-vibrator plus multi-particle-hole description. It is shown that a series of experimentally observed 0+ states in these nuclei may be interpreted as the multi-particle-hole excitations in a complementary manner to the beta and gamma vibrations described by the rotor-vibrator model. As a typical example of the model application, low-lying positive parity level energies below 1.990 MeV in …

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Health Physics Workforce In The United States, Michael A. Noska, Caridad Borrás, E. Vincent Holahan, Shaheen A. Dewji, Thomas E. Johnson, Jerry W. Hiatt, Wayne D. Newhauser, John W. Poston, Nolan Hertel Dec 2022

Health Physics Workforce In The United States, Michael A. Noska, Caridad Borrás, E. Vincent Holahan, Shaheen A. Dewji, Thomas E. Johnson, Jerry W. Hiatt, Wayne D. Newhauser, John W. Poston, Nolan Hertel

Faculty Publications

No abstract provided.

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Medical Physics Workforce In The United States, Wayne D. Newhauser, Dustin A. Gress, Michael D. Mills, David W. Jordan, Steven G. Sutlief, Melissa C. Martin, Edward Jackson Dec 2022

Medical Physics Workforce In The United States, Wayne D. Newhauser, Dustin A. Gress, Michael D. Mills, David W. Jordan, Steven G. Sutlief, Melissa C. Martin, Edward Jackson

Faculty Publications

No abstract provided.

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Anisotropic Superconductivity Of Niobium Based On Its Response To Nonmagnetic Disorder, Makariy A. Tanatar, Daniele Torsello, Kamal R. Joshi, Sunil Ghimire, Cameron J. Kopas, Jayss Marshall, Josh Y. Mutus, Gianluca Ghigo, Mehdi Zarea, James A. Sauls, Ruslan Prozorov Dec 2022

Anisotropic Superconductivity Of Niobium Based On Its Response To Nonmagnetic Disorder, Makariy A. Tanatar, Daniele Torsello, Kamal R. Joshi, Sunil Ghimire, Cameron J. Kopas, Jayss Marshall, Josh Y. Mutus, Gianluca Ghigo, Mehdi Zarea, James A. Sauls, Ruslan Prozorov

Faculty Publications

Niobium is one of the most studied superconductors, both theoretically and experimentally. It is tremendously important for applications, and it has the highest superconducting transition temperature, Tc=9.32 K, of all pure metals. In addition to power applications in alloys, pure niobium is used for sensitive magnetosensing, radio-frequency cavities, and, more recently, as circuit metallization layers in superconducting qubits. A detailed understanding of its electronic and superconducting structure, especially its normal and superconducting state anisotropies, is crucial for mitigating the loss of quantum coherence in such devices. Recently, a microscopic theory of the anisotropic properties of niobium with the disorder was …

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Detecting Quantum Critical Points Of Correlated Systems By Quantum Convolutional Neural Network Using Data From Variational Quantum Eigensolver, Nathaniel Wrobel, Anshumitra Baul, Ka Ming Tam, Juana Moreno Dec 2022

Detecting Quantum Critical Points Of Correlated Systems By Quantum Convolutional Neural Network Using Data From Variational Quantum Eigensolver, Nathaniel Wrobel, Anshumitra Baul, Ka Ming Tam, Juana Moreno

Faculty Publications

Machine learning has been applied to a wide variety of models, from classical statistical mechanics to quantum strongly correlated systems, for classifying phase transitions. The recently proposed quantum convolutional neural network (QCNN) provides a new framework for using quantum circuits instead of classical neural networks as the backbone of classification methods. We present the results from training the QCNN by the wavefunctions of the variational quantum eigensolver for the one-dimensional transverse field Ising model (TFIM). We demonstrate that the QCNN identifies wavefunctions corresponding to the paramagnetic and ferromagnetic phases of the TFIM with reasonable accuracy. The QCNN can be trained …

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Influence Of State Reopening Policies In Covid-19 Mortality, Ka Ming Tam, Nicholas Walker, Juana Moreno Dec 2022

Influence Of State Reopening Policies In Covid-19 Mortality, Ka Ming Tam, Nicholas Walker, Juana Moreno

Faculty Publications

By the end of May 2020, all states in the US have eased their COVID-19 mitigation measures. Different states adopted markedly different policies and timing for reopening. An important question remains in how the relaxation of mitigation measures is related to the number of casualties. To address this question, we compare the actual data to a hypothetical case in which the mitigation measures are left intact using a projection of the data from before mitigation measures were eased. We find that different states have shown significant differences between the actual number of deaths and the projected figures within the present …

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Linkages Between Bacterial Community And Extracellular Enzyme Activities Crossing A Coastal Front, Shujie Cai, Feipeng Wang, Edward A. Laws, Yao Liu, Chao Xu, Lingqi Ma, Wupeng Xiao, Bangqin Huang Dec 2022

Linkages Between Bacterial Community And Extracellular Enzyme Activities Crossing A Coastal Front, Shujie Cai, Feipeng Wang, Edward A. Laws, Yao Liu, Chao Xu, Lingqi Ma, Wupeng Xiao, Bangqin Huang

Faculty Publications

Exploring the responses of microbial communities and their functions to marine frontal systems are the foci of marine ecologists. However, most of the existing studies have focused on only microbial communities or their functions. The relationships between microbial communities and their functions across coastal fronts therefore remain unclear. Here we studied a coastal front in the Taiwan Strait during late spring and examined the bacterial community structure, extracellular enzymatic activity (EEA), and their linkages. The results showed that the coastal front strongly delineated zones of bacterial community composition and diversity and functioned as a transitional zone rather than a hotspot …

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Greater Evolutionary Divergence Of Thermal Limits Within Marine Than Terrestrial Species, Matthew Sasaki, Jordanna M. Barley, Sarah Gignoux-Wolfsohn, Cynthia G. Hays, Morgan W. Kelly, Alysha B. Putnam, Seema N. Sheth, Andrew R. Villeneuve, Brian S. Cheng Dec 2022

Greater Evolutionary Divergence Of Thermal Limits Within Marine Than Terrestrial Species, Matthew Sasaki, Jordanna M. Barley, Sarah Gignoux-Wolfsohn, Cynthia G. Hays, Morgan W. Kelly, Alysha B. Putnam, Seema N. Sheth, Andrew R. Villeneuve, Brian S. Cheng

Faculty Publications

There is considerable uncertainty regarding which ecosystems are most vulnerable to warming. Current understanding of organismal sensitivity is largely centred on species-level assessments that do not consider variation across populations. Here we used meta-analysis to quantify upper thermal tolerance variation across 305 populations from 61 terrestrial, freshwater, marine and intertidal taxa. We found strong differentiation in heat tolerance across populations in marine and intertidal taxa but not terrestrial or freshwater taxa. This is counter to the expectation that increased connectivity in the ocean should reduce intraspecific variation. Such adaptive differentiation in the ocean suggests there may be standing genetic variation …

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