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2022

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Articles 7411 - 7440 of 167994

Full-Text Articles in Entire DC Network

Associations Between Polygenic Risk, Negative Symptoms, And Functional Connectome Topology During A Working Memory Task In Early-Onset Schizophrenia, Mengjie Deng, Zhening Liu, Wen Zhang, Zhipeng Wu, Hengyi Cao, Jie Yang, Lena Palaniyappan Dec 2022

Associations Between Polygenic Risk, Negative Symptoms, And Functional Connectome Topology During A Working Memory Task In Early-Onset Schizophrenia, Mengjie Deng, Zhening Liu, Wen Zhang, Zhipeng Wu, Hengyi Cao, Jie Yang, Lena Palaniyappan

Neuroscience Institute Publications

Working memory (WM) deficit in schizophrenia is thought to arise from a widespread neural inefficiency. However, we do not know if this deficit results from the illness-related genetic risk and influence the symptom burden in various domains, especially in patients who have an early onset illness. We used graph theory to examine the topology of the functional connectome in 99 subjects (27 early-onset schizophrenia (EOS), 24 asymptomatic siblings, and 48 healthy subjects) during an n-back task, and calculated their polygenic risk score (PRS) for susceptibility to schizophrenia. Linear regression analysis was used to test associations of the PRS, clinical symptoms, …

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Progressive Changes In Descriptive Discourse In First Episode Schizophrenia: A Longitudinal Computational Semantics Study, Maria Francisca Alonso-Sánchez, Sabrina D. Ford, Michael Mackinley, Angélica Silva, Roberto Limongi, Lena Palaniyappan Dec 2022

Progressive Changes In Descriptive Discourse In First Episode Schizophrenia: A Longitudinal Computational Semantics Study, Maria Francisca Alonso-Sánchez, Sabrina D. Ford, Michael Mackinley, Angélica Silva, Roberto Limongi, Lena Palaniyappan

Neuroscience Institute Publications

Computational semantics, a branch of computational linguistics, involves automated meaning analysis that relies on how words occur together in natural language. This offers a promising tool to study schizophrenia. At present, we do not know if these word-level choices in speech are sensitive to the illness stage (i.e., acute untreated vs. stable established state), track cognitive deficits in major domains (e.g., cognitive control, processing speed) or relate to established dimensions of formal thought disorder. In this study, we collected samples of descriptive discourse in patients experiencing an untreated first episode of schizophrenia and healthy control subjects (246 samples of 1-minute …

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Bilateral Sequential Theta Burst Stimulation In Depressed Veterans With Service Related Posttraumatic Stress Disorder: A Feasibility Study, Thelepa Vaithianathan, Mervin Blair, Vanessa Soares, Yuri E. Rybak, Lena Palaniyappan, J. Don Richardson, Amer M. Burhan Dec 2022

Bilateral Sequential Theta Burst Stimulation In Depressed Veterans With Service Related Posttraumatic Stress Disorder: A Feasibility Study, Thelepa Vaithianathan, Mervin Blair, Vanessa Soares, Yuri E. Rybak, Lena Palaniyappan, J. Don Richardson, Amer M. Burhan

Neuroscience Institute Publications

Background: Depression comorbid with posttraumatic stress disorder (PTSD) can be disabling and treatment resistant. Preliminary evidence suggests that repetitive transcranial magnetic stimulation (rTMS), may have a role in helping these patients. There are only few published studies using different rTMS paradigms including bilateral intermittent theta burst (iTBS) and low frequency rTMS. Methods: In this small cohort observation study, we examined the efficacy of bilateral sequential theta-burst stimulation (bsTBS) in 8 treatment resistant depression (TRD) military veterans with PTSD comorbidity stemming from military service experience. Results: bsTBS was generally well tolerated and resulted in 25% and 38% remission and response rates …

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Perceptual Decision-Making In Autism As Assessed By “Spot The Difference” Visual Cognition Tasks, Nazia Jassim, Adrian M. Owen, Paula Smith, John Suckling, Rebecca P. Lawson, Simon Baron-Cohen, Owen Parsons Dec 2022

Perceptual Decision-Making In Autism As Assessed By “Spot The Difference” Visual Cognition Tasks, Nazia Jassim, Adrian M. Owen, Paula Smith, John Suckling, Rebecca P. Lawson, Simon Baron-Cohen, Owen Parsons

Neuroscience Institute Publications

Discriminating between similar figures proves to be a remarkably demanding task due to the limited capacity of our visual cognitive processes. Here we examine how perceptual inference and decision-making are modulated by differences arising from neurodiversity. A large sample of autistic (n = 140) and typical (n = 147) participants completed two forced choice similarity judgement tasks online. Each task consisted of “match” (identical figures) and “mismatch” (subtle differences between figures) conditions. Signal detection theory analyses indicated a response bias by the autism group during conditions of uncertainty. More specifically, autistic participants were more likely to choose the “mismatch” option, …

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Whole-Brain Modelling Identifies Distinct But Convergent Paths To Unconsciousness In Anaesthesia And Disorders Of Consciousness, Andrea I. Luppi, Pedro A.M. Mediano, Fernando E. Rosas, Judith Allanson, John D. Pickard, Guy B. Williams, Michael M. Craig, Paola Finoia, Alexander R.D. Peattie, Peter Coppola, Adrian M. Owen, Lorina Naci, David K. Menon, Daniel Bor, Emmanuel A. Stamatakis Dec 2022

Whole-Brain Modelling Identifies Distinct But Convergent Paths To Unconsciousness In Anaesthesia And Disorders Of Consciousness, Andrea I. Luppi, Pedro A.M. Mediano, Fernando E. Rosas, Judith Allanson, John D. Pickard, Guy B. Williams, Michael M. Craig, Paola Finoia, Alexander R.D. Peattie, Peter Coppola, Adrian M. Owen, Lorina Naci, David K. Menon, Daniel Bor, Emmanuel A. Stamatakis

Neuroscience Institute Publications

The human brain entertains rich spatiotemporal dynamics, which are drastically reconfigured when consciousness is lost due to anaesthesia or disorders of consciousness (DOC). Here, we sought to identify the neurobiological mechanisms that explain how transient pharmacological intervention and chronic neuroanatomical injury can lead to common reconfigurations of neural activity. We developed and systematically perturbed a neurobiologically realistic model of whole-brain haemodynamic signals. By incorporating PET data about the cortical distribution of GABA receptors, our computational model reveals a key role of spatially-specific local inhibition for reproducing the functional MRI activity observed during anaesthesia with the GABA-ergic agent propofol. Additionally, incorporating …

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Prenatal And Postpartum Maternal Mental Health And Neonatal Motor Outcomes During The Covid-19 Pandemic, Alissa Papadopoulos, Emily S. Nichols, Yalda Mohsenzadeh, Isabelle Giroux, Michelle F. Mottola, Ryan J. Van Lieshout, Emma G. Duerden Dec 2022

Prenatal And Postpartum Maternal Mental Health And Neonatal Motor Outcomes During The Covid-19 Pandemic, Alissa Papadopoulos, Emily S. Nichols, Yalda Mohsenzadeh, Isabelle Giroux, Michelle F. Mottola, Ryan J. Van Lieshout, Emma G. Duerden

Neuroscience Institute Publications

Background: Rates of prenatal and postpartum stress and depression in pregnant individuals have increased during the COVID-19 pandemic. Perinatal maternal mental health has been linked to worse motor development in offspring, with motor deficits appearing in infancy and early childhood. We aimed to evaluate the relationship between prenatal and postpartum stress and depression and motor outcome in infants born during the COVID-19 pandemic. Methods: One hundred and seventeen participants completed an online prospective survey study at two timepoints: during pregnancy and within 2 months postpartum. Depression was self-reported using the Edinburgh Perinatal/Postpartum Depression Scale (EPDS), and stress via the Perceived …

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Risk Factors For Comorbid Epilepsy In Patients With Psychogenic Non-Epileptic Seizures. Dataset Of A Large Cohort Study, Andreu Massot-Tarrús, Yeyao Joe Yu, Mashael Alkhateeb, Seyed M. Mirsattari Dec 2022

Risk Factors For Comorbid Epilepsy In Patients With Psychogenic Non-Epileptic Seizures. Dataset Of A Large Cohort Study, Andreu Massot-Tarrús, Yeyao Joe Yu, Mashael Alkhateeb, Seyed M. Mirsattari

Neuroscience Institute Publications

Psychogenic non-epileptic seizures (PNES) are the main differential diagnosis of pharmacorresistant epilepsy. Achieving the certainty in the diagnosis of PNES may be challenging, especially in the 10-22% of cases in which PNES and epilepsy co-exist. This difficulty hampers the management of these patients. Unfortunately, published series with this combined pathology are scarce and small in size. This article presents the dataset of our article “Factors associated with comorbid epilepsy in patients with psychogenic non-epileptic seizures: a large cohort study” (Massot-Tarrús et al. 2022). It is composed by a detailed demographic and clinical data of 271 consecutive patients diagnosed with PNES …

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National Identity Predicts Public Health Support During A Global Pandemic, Jay J. Van Bavel, Aleksandra Cichocka, Valerio Capraro, Hallgeir Sjåstad, John B. Nezlek, Tomislav Pavlović, Mark Alfano, Michele J. Gelfand, Flavio Azevedo, Michèle D. Birtel, Aleksandra Cislak, Patricia L. Lockwood, Robert Malcolm Ross, Koen Abts, Elena Agadullina, John Jamir Benzon Aruta, Sahba Nomvula Besharati, Alexander Bor, Becky L. Choma, Charles David Crabtree, William A. Cunningham, Koustav De, Waqas Ejaz, Christian T. Elbaek, Andrej Findor, Daniel Flichtentrei, Renata Franc, Biljana Gjoneska, June Gruber, Estrella Gualda Dec 2022

National Identity Predicts Public Health Support During A Global Pandemic, Jay J. Van Bavel, Aleksandra Cichocka, Valerio Capraro, Hallgeir Sjåstad, John B. Nezlek, Tomislav Pavlović, Mark Alfano, Michele J. Gelfand, Flavio Azevedo, Michèle D. Birtel, Aleksandra Cislak, Patricia L. Lockwood, Robert Malcolm Ross, Koen Abts, Elena Agadullina, John Jamir Benzon Aruta, Sahba Nomvula Besharati, Alexander Bor, Becky L. Choma, Charles David Crabtree, William A. Cunningham, Koustav De, Waqas Ejaz, Christian T. Elbaek, Andrej Findor, Daniel Flichtentrei, Renata Franc, Biljana Gjoneska, June Gruber, Estrella Gualda

Neuroscience Institute Publications

Changing collective behaviour and supporting non-pharmaceutical interventions is an important component in mitigating virus transmission during a pandemic. In a large international collaboration (Study 1, N = 49,968 across 67 countries), we investigated self-reported factors associated with public health behaviours (e.g., spatial distancing and stricter hygiene) and endorsed public policy interventions (e.g., closing bars and restaurants) during the early stage of the COVID-19 pandemic (April-May 2020). Respondents who reported identifying more strongly with their nation consistently reported greater engagement in public health behaviours and support for public health policies. Results were similar for representative and non-representative national samples. Study 2 …

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Glutamine And Gaba Alterations In Cingulate Cortex May Underlie Alcohol Drinking In A Rat Model Of Co-Occurring Alcohol Use Disorder And Schizophrenia: An 1h-Mrs Study, Patrick Mccunn, Xi Chen, Barjor Gimi, Alan I. Green, Jibran Y. Khokhar Dec 2022

Glutamine And Gaba Alterations In Cingulate Cortex May Underlie Alcohol Drinking In A Rat Model Of Co-Occurring Alcohol Use Disorder And Schizophrenia: An 1h-Mrs Study, Patrick Mccunn, Xi Chen, Barjor Gimi, Alan I. Green, Jibran Y. Khokhar

Neuroscience Institute Publications

Alcohol use disorder commonly occurs in patients with schizophrenia and significantly worsens the clinical course of the disorder. The neurobiological underpinnings of alcohol drinking are not well understood. Magnetic resonance spectroscopy (MRS) has been used to assess the neurochemical substrates that may be associated with alcohol drinking in patients; however, the causal impact of these findings remains elusive, highlighting the need for studies in animal models. This study performed MRS in the neonatal ventral hippocampal lesioned (NVHL) rat model, a model of co-occurring schizophrenia and substance use disorders. NVHL lesions (or sham surgeries) were performed on post-natal day 7 and …

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Maternal Immune Activation And Adolescent Alcohol Exposure Increase Alcohol Drinking And Disrupt Cortical-Striatal-Hippocampal Oscillations In Adult Offspring, Angela M. Henricks, Emily D.K. Sullivan, Lucas L. Dwiel, Judy Y. Li, Diana J. Wallin, Jibran Y. Khokhar, Wilder T. Doucette Dec 2022

Maternal Immune Activation And Adolescent Alcohol Exposure Increase Alcohol Drinking And Disrupt Cortical-Striatal-Hippocampal Oscillations In Adult Offspring, Angela M. Henricks, Emily D.K. Sullivan, Lucas L. Dwiel, Judy Y. Li, Diana J. Wallin, Jibran Y. Khokhar, Wilder T. Doucette

Neuroscience Institute Publications

Maternal immune activation (MIA) is strongly associated with an increased risk of developing mental illness in adulthood, which often co-occurs with alcohol misuse. The current study aimed to begin to determine whether MIA, combined with adolescent alcohol exposure (AE), could be used as a model with which we could study the neurobiological mechanisms behind such co-occurring disorders. Pregnant Sprague-Dawley rats were treated with polyI:C or saline on gestational day 15. Half of the offspring were given continuous access to alcohol during adolescence, leading to four experimental groups: controls, MIA, AE, and Dual (MIA + AE). We then evaluated whether MIA …

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Qmri-Bids: An Extension To The Brain Imaging Data Structure For Quantitative Magnetic Resonance Imaging Data, Agah Karakuzu, Stefan Appelhoff, Tibor Auer, Mathieu Boudreau, Franklin Feingold, Ali R. Khan, Alberto Lazari, Chris Markiewicz, Martijn Mulder, Christophe Phillips, Taylor Salo, Nikola Stikov, Kirstie Whitaker, Gilles De Hollander Dec 2022

Qmri-Bids: An Extension To The Brain Imaging Data Structure For Quantitative Magnetic Resonance Imaging Data, Agah Karakuzu, Stefan Appelhoff, Tibor Auer, Mathieu Boudreau, Franklin Feingold, Ali R. Khan, Alberto Lazari, Chris Markiewicz, Martijn Mulder, Christophe Phillips, Taylor Salo, Nikola Stikov, Kirstie Whitaker, Gilles De Hollander

Neuroscience Institute Publications

The Brain Imaging Data Structure (BIDS) established community consensus on the organization of data and metadata for several neuroimaging modalities. Traditionally, BIDS had a strong focus on functional magnetic resonance imaging (MRI) datasets and lacked guidance on how to store multimodal structural MRI datasets. Here, we present and describe the BIDS Extension Proposal 001 (BEP001), which adds a range of quantitative MRI (qMRI) applications to the BIDS. In general, the aim of qMRI is to characterize brain microstructure by quantifying the physical MR parameters of the tissue via computational, biophysical models. By proposing this new standard, we envision standardization of …

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Age-Related Deficits In Dip-Listening Evident For Isolated Sentences But Not For Spoken Stories, Vanessa C. Irsik, Ingrid S. Johnsrude, Björn Herrmann Dec 2022

Age-Related Deficits In Dip-Listening Evident For Isolated Sentences But Not For Spoken Stories, Vanessa C. Irsik, Ingrid S. Johnsrude, Björn Herrmann

Neuroscience Institute Publications

Fluctuating background sounds facilitate speech intelligibility by providing speech ‘glimpses’ (masking release). Older adults benefit less from glimpses, but masking release is typically investigated using isolated sentences. Recent work indicates that using engaging, continuous speech materials (e.g., spoken stories) may qualitatively alter speech-in-noise listening. Moreover, neural sensitivity to different amplitude envelope profiles (ramped, damped) changes with age, but whether this affects speech listening is unknown. In three online experiments, we investigate how masking release in younger and older adults differs for masked sentences and stories, and how speech intelligibility varies with masker amplitude profile. Intelligibility was generally greater for damped …

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Smiling Makes You Look Older, Even When You Wear A Mask: The Effect Of Face Masks On Age Perception, Tzvi Ganel, Melvyn A. Goodale Dec 2022

Smiling Makes You Look Older, Even When You Wear A Mask: The Effect Of Face Masks On Age Perception, Tzvi Ganel, Melvyn A. Goodale

Neuroscience Institute Publications

The widespread use of face masks in the era of the Covid-19 pandemic has promoted research on their effect on the perception and recognition of faces. There is growing evidence that masks hinder the recognition of identity and expression, as well as the interpretation of speech from facial cues. It is less clear whether and in what manner masks affect the perception of age from facial cues. Recent research has emphasized the role of the upper region of the face, a part not covered by a mask, in the evaluation of age. For example, smile-related wrinkles in the region of …

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Elevated Vascular Transformation Blood Biomarkers In Long-Covid Indicate Angiogenesis As A Key Pathophysiological Mechanism, Maitray A. Patel, Michael J. Knauer, Michael Nicholson, Mark Daley, Logan R. Van Nynatten, Claudio Martin, Eric K. Patterson, Gediminas Cepinskas, Shannon L. Seney, Verena Dobretzberger, Markus Miholits, Brian Webb, Douglas D. Fraser Dec 2022

Elevated Vascular Transformation Blood Biomarkers In Long-Covid Indicate Angiogenesis As A Key Pathophysiological Mechanism, Maitray A. Patel, Michael J. Knauer, Michael Nicholson, Mark Daley, Logan R. Van Nynatten, Claudio Martin, Eric K. Patterson, Gediminas Cepinskas, Shannon L. Seney, Verena Dobretzberger, Markus Miholits, Brian Webb, Douglas D. Fraser

Neuroscience Institute Publications

Background: Long-COVID is characterized by prolonged, diffuse symptoms months after acute COVID-19. Accurate diagnosis and targeted therapies for Long-COVID are lacking. We investigated vascular transformation biomarkers in Long-COVID patients. Methods: A case–control study utilizing Long-COVID patients, one to six months (median 98.5 days) post-infection, with multiplex immunoassay measurement of sixteen blood biomarkers of vascular transformation, including ANG-1, P-SEL, MMP-1, VE-Cad, Syn-1, Endoglin, PECAM-1, VEGF-A, ICAM-1, VLA-4, E-SEL, thrombomodulin, VEGF-R2, VEGF-R3, VCAM-1 and VEGF-D. Results: Fourteen vasculature transformation blood biomarkers were significantly elevated in Long-COVID outpatients, versus acutely ill COVID-19 inpatients and healthy controls subjects (P < 0.05). A unique two biomarker profile consisting of ANG-1/P-SEL was developed with machine learning, providing a classification accuracy for Long-COVID status of 96%. Individually, ANG-1 and P-SEL had excellent sensitivity and specificity for Long-COVID status (AUC = 1.00, P < 0.0001; validated in a secondary cohort). Specific to Long-COVID, ANG-1 levels were associated with female sex and a lack of disease interventions at follow-up (P < 0.05). Conclusions: Long-COVID patients suffer prolonged, diffuse symptoms and poorer health. Vascular transformation blood biomarkers were significantly elevated in Long-COVID, with angiogenesis markers (ANG-1/P-SEL) providing classification accuracy of 96%. Vascular transformation blood biomarkers hold potential for diagnostics, and modulators of angiogenesis may have therapeutic efficacy.

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Elevated Vascular Transformation Blood Biomarkers In Long-Covid Indicate Angiogenesis As A Key Pathophysiological Mechanism, Maitray A. Patel, Michael J. Knauer, Michael Nicholson, Mark Daley, Logan R. Van Nynatten, Claudio Martin, Eric K. Patterson, Gediminas Cepinskas, Shannon L. Seney, Verena Dobretzberger, Markus Miholits, Brian Webb, Douglas D. Fraser Dec 2022

Elevated Vascular Transformation Blood Biomarkers In Long-Covid Indicate Angiogenesis As A Key Pathophysiological Mechanism, Maitray A. Patel, Michael J. Knauer, Michael Nicholson, Mark Daley, Logan R. Van Nynatten, Claudio Martin, Eric K. Patterson, Gediminas Cepinskas, Shannon L. Seney, Verena Dobretzberger, Markus Miholits, Brian Webb, Douglas D. Fraser

Neuroscience Institute Publications

Background: Long-COVID is characterized by prolonged, diffuse symptoms months after acute COVID-19. Accurate diagnosis and targeted therapies for Long-COVID are lacking. We investigated vascular transformation biomarkers in Long-COVID patients. Methods: A case–control study utilizing Long-COVID patients, one to six months (median 98.5 days) post-infection, with multiplex immunoassay measurement of sixteen blood biomarkers of vascular transformation, including ANG-1, P-SEL, MMP-1, VE-Cad, Syn-1, Endoglin, PECAM-1, VEGF-A, ICAM-1, VLA-4, E-SEL, thrombomodulin, VEGF-R2, VEGF-R3, VCAM-1 and VEGF-D. Results: Fourteen vasculature transformation blood biomarkers were significantly elevated in Long-COVID outpatients, versus acutely ill COVID-19 inpatients and healthy controls subjects (P < 0.05). A unique two biomarker profile consisting of ANG-1/P-SEL was developed with machine learning, providing a classification accuracy for Long-COVID status of 96%. Individually, ANG-1 and P-SEL had excellent sensitivity and specificity for Long-COVID status (AUC = 1.00, P < 0.0001; validated in a secondary cohort). Specific to Long-COVID, ANG-1 levels were associated with female sex and a lack of disease interventions at follow-up (P < 0.05). Conclusions: Long-COVID patients suffer prolonged, diffuse symptoms and poorer health. Vascular transformation blood biomarkers were significantly elevated in Long-COVID, with angiogenesis markers (ANG-1/P-SEL) providing classification accuracy of 96%. Vascular transformation blood biomarkers hold potential for diagnostics, and modulators of angiogenesis may have therapeutic efficacy.

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Frontoparietal Connectivity As A Product Of Convergent Evolution In Rodents And Primates: Functional Connectivity Topologies In Grey Squirrels, Rats, And Marmosets, David J. Schaeffer, Kyle M. Gilbert, Miranda Bellyou, Afonso C. Silva, Stefan Everling Dec 2022

Frontoparietal Connectivity As A Product Of Convergent Evolution In Rodents And Primates: Functional Connectivity Topologies In Grey Squirrels, Rats, And Marmosets, David J. Schaeffer, Kyle M. Gilbert, Miranda Bellyou, Afonso C. Silva, Stefan Everling

Neuroscience Institute Publications

Robust frontoparietal connectivity is a defining feature of primate cortical organization. Whether mammals outside the primate order, such as rodents, possess similar frontoparietal functional connectivity organization is a controversial topic. Previous work has primarily focused on comparing mice and rats to primates. However, as these rodents are nocturnal and terrestrial, they rely much less on visual input than primates. Here, we investigated the functional cortical organization of grey squirrels which are diurnal and arboreal, thereby better resembling primate ecology. We used ultra-high field resting-state fMRI data to compute and compare the functional connectivity patterns of frontal regions in grey squirrels …

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Elevated Csf And Plasma Complement Proteins In Genetic Frontotemporal Dementia: Results From The Genfi Study, Emma L. Van Der Ende, Carolin Heller, Aitana Sogorb-Esteve, Imogen J. Swift, David Mcfall, Georgia Peakman, Arabella Bouzigues, Jackie M. Poos, Lize C. Jiskoot, Jessica L. Panman, Janne M. Papma, Lieke H. Meeter, Elise G.P. Dopper, Martina Bocchetta, Emily Todd, David Cash, Caroline Graff, Matthis Synofzik, Fermin Moreno, Elizabeth Finger, Raquel Sanchez-Valle, Rik Vandenberghe, Robert Laforce, Mario Masellis, Maria Carmela Tartaglia, James B. Rowe, Chris Butler, Simon Ducharme, Alexander Gerhard, Adrian Danek Dec 2022

Elevated Csf And Plasma Complement Proteins In Genetic Frontotemporal Dementia: Results From The Genfi Study, Emma L. Van Der Ende, Carolin Heller, Aitana Sogorb-Esteve, Imogen J. Swift, David Mcfall, Georgia Peakman, Arabella Bouzigues, Jackie M. Poos, Lize C. Jiskoot, Jessica L. Panman, Janne M. Papma, Lieke H. Meeter, Elise G.P. Dopper, Martina Bocchetta, Emily Todd, David Cash, Caroline Graff, Matthis Synofzik, Fermin Moreno, Elizabeth Finger, Raquel Sanchez-Valle, Rik Vandenberghe, Robert Laforce, Mario Masellis, Maria Carmela Tartaglia, James B. Rowe, Chris Butler, Simon Ducharme, Alexander Gerhard, Adrian Danek

Neuroscience Institute Publications

Background: Neuroinflammation is emerging as an important pathological process in frontotemporal dementia (FTD), but biomarkers are lacking. We aimed to determine the value of complement proteins, which are key components of innate immunity, as biomarkers in cerebrospinal fluid (CSF) and plasma of presymptomatic and symptomatic genetic FTD mutation carriers. Methods: We measured the complement proteins C1q and C3b in CSF by ELISAs in 224 presymptomatic and symptomatic GRN, C9orf72 or MAPT mutation carriers and non-carriers participating in the Genetic Frontotemporal Dementia Initiative (GENFI), a multicentre cohort study. Next, we used multiplex immunoassays to measure a panel of 14 complement proteins …

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Differential Impairment Of Cerebrospinal Fluid Synaptic Biomarkers In The Genetic Forms Of Frontotemporal Dementia, Aitana Sogorb-Esteve, Johanna Nilsson, Imogen J. Swift, Carolin Heller, Martina Bocchetta, Lucy L. Russell, Georgia Peakman, Rhian S. Convery, John C. Van Swieten, Harro Seelaar, Barbara Borroni, Daniela Galimberti, Raquel Sanchez-Valle, Robert Laforce, Fermin Moreno, Matthis Synofzik, Caroline Graff, Mario Masellis, Maria Carmela Tartaglia, James B. Rowe, Rik Vandenberghe, Elizabeth Finger, Fabrizio Tagliavini, Isabel Santana, Chris R. Butler, Simon Ducharme, Alexander Gerhard, Adrian Danek, Johannes Levin, Markus Otto Dec 2022

Differential Impairment Of Cerebrospinal Fluid Synaptic Biomarkers In The Genetic Forms Of Frontotemporal Dementia, Aitana Sogorb-Esteve, Johanna Nilsson, Imogen J. Swift, Carolin Heller, Martina Bocchetta, Lucy L. Russell, Georgia Peakman, Rhian S. Convery, John C. Van Swieten, Harro Seelaar, Barbara Borroni, Daniela Galimberti, Raquel Sanchez-Valle, Robert Laforce, Fermin Moreno, Matthis Synofzik, Caroline Graff, Mario Masellis, Maria Carmela Tartaglia, James B. Rowe, Rik Vandenberghe, Elizabeth Finger, Fabrizio Tagliavini, Isabel Santana, Chris R. Butler, Simon Ducharme, Alexander Gerhard, Adrian Danek, Johannes Levin, Markus Otto

Neuroscience Institute Publications

Background: Approximately a third of frontotemporal dementia (FTD) is genetic with mutations in three genes accounting for most of the inheritance: C9orf72, GRN, and MAPT. Impaired synaptic health is a common mechanism in all three genetic variants, so developing fluid biomarkers of this process could be useful as a readout of cellular dysfunction within therapeutic trials. Methods: A total of 193 cerebrospinal fluid (CSF) samples from the GENetic FTD Initiative including 77 presymptomatic (31 C9orf72, 23 GRN, 23 MAPT) and 55 symptomatic (26 C9orf72, 17 GRN, 12 MAPT) mutation carriers as well as 61 mutation-negative controls were measured using a …

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Cognitive Composites For Genetic Frontotemporal Dementia: Genfi-Cog, Jackie M. Poos, Katrina M. Moore, Jennifer Nicholas, Lucy L. Russell, Georgia Peakman, Rhian S. Convery, Lize C. Jiskoot, Emma Van Der Ende, Esther Van Den Berg, Janne M. Papma, Harro Seelaar, Yolande A.L. Pijnenburg, Fermin Moreno, Raquel Sanchez-Valle, Barbara Borroni, Robert Laforce, Mario Masellis, Carmela Tartaglia, Caroline Graff, Daniela Galimberti, James B. Rowe, Elizabeth Finger, Matthis Synofzik, Rik Vandenberghe, Alexandre De Mendonça, Pietro Tiraboschi, Isabel Santana, Simon Ducharme, Chris Butler, Alexander Gerhard Dec 2022

Cognitive Composites For Genetic Frontotemporal Dementia: Genfi-Cog, Jackie M. Poos, Katrina M. Moore, Jennifer Nicholas, Lucy L. Russell, Georgia Peakman, Rhian S. Convery, Lize C. Jiskoot, Emma Van Der Ende, Esther Van Den Berg, Janne M. Papma, Harro Seelaar, Yolande A.L. Pijnenburg, Fermin Moreno, Raquel Sanchez-Valle, Barbara Borroni, Robert Laforce, Mario Masellis, Carmela Tartaglia, Caroline Graff, Daniela Galimberti, James B. Rowe, Elizabeth Finger, Matthis Synofzik, Rik Vandenberghe, Alexandre De Mendonça, Pietro Tiraboschi, Isabel Santana, Simon Ducharme, Chris Butler, Alexander Gerhard

Neuroscience Institute Publications

Background: Clinical endpoints for upcoming therapeutic trials in frontotemporal dementia (FTD) are increasingly urgent. Cognitive composite scores are often used as endpoints but are lacking in genetic FTD. We aimed to create cognitive composite scores for genetic frontotemporal dementia (FTD) as well as recommendations for recruitment and duration in clinical trial design. Methods: A standardized neuropsychological test battery covering six cognitive domains was completed by 69 C9orf72, 41 GRN, and 28 MAPT mutation carriers with CDR® plus NACC-FTLD ≥ 0.5 and 275 controls. Logistic regression was used to identify the combination of tests that distinguished best between each mutation carrier …

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Thermal Effect On Dislocation Interactions In Magnesium Alloy, Yuzhi Zhu, Yi Chen, Dewen Hou, Zidong Wang Dec 2022

Thermal Effect On Dislocation Interactions In Magnesium Alloy, Yuzhi Zhu, Yi Chen, Dewen Hou, Zidong Wang

Materials Science and Engineering Faculty Publications and Presentations

In this work, dislocation interactions are directly observed and analyzed by using in-situ transmission electron microscope during heating processes in a pre-deformed Mg-3Al-1Zn magnesium alloy. Thermodynamic behaviors of two types of dislocations are investigated, i.e., individual dislocations and low-angle grain boundary arranged by dislocations. The results show that the low-angle grain boundary remains stable as the heating temperature increases to 673 K, while most of the individual dislocations disappear until the heating temperature reaches 473 K. Furthermore, the low-angle grain boundary tends to absorb individual dislocations nearby. The stability and the annihilation of both types of dislocations are discussed.

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Won't You Be My Senator?: Nuanced “Friends And Neighbors” Voting In U.S. Senate Elections, 1968–2018, Charles R. Hunt Dec 2022

Won't You Be My Senator?: Nuanced “Friends And Neighbors” Voting In U.S. Senate Elections, 1968–2018, Charles R. Hunt

Political Science Faculty Publications and Presentations

Recent experimental scholarship shows that local “place identity” continues to matter to voters' assessments of candidates, echoing early findings by Key (1949) and others demonstrating electoral boosts in candidates’ home areas. But it is yet to reexamine these “friends-and-neighbors” effects in the observational context, nor does it parse differences between effects of local candidate roots and current candidate residency. This paper closes these gaps using an original county-level dataset of incumbent reelection races for the U.S. Senate from 1968 to 2018 (N = ∼34,000 county-years). I show that the friends-and-neighbors effect is more nuanced than previously thought, applying to candidate …

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Front Cover - Tiles In The Sky, Christine Cianciosi Dec 2022

Front Cover - Tiles In The Sky, Christine Cianciosi

The Prairie Light Review

No abstract provided.

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On The News, Karen Kuchar Dec 2022

On The News, Karen Kuchar

The Prairie Light Review

No abstract provided.

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Red Madonna Speaking Truths, Carolyn Faivre Dec 2022

Red Madonna Speaking Truths, Carolyn Faivre

The Prairie Light Review

No abstract provided.

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White Orchid, Kimberly Smuksta Dec 2022

White Orchid, Kimberly Smuksta

The Prairie Light Review

No abstract provided.

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Hector, My Boy, Mia Skaliotis Dec 2022

Hector, My Boy, Mia Skaliotis

The Prairie Light Review

No abstract provided.

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Gender Equality, Climate Change And Agriculture In The Mena Region: Priorities And Possibilities, Bipasha Baruah, Dina Najjar Dec 2022

Gender Equality, Climate Change And Agriculture In The Mena Region: Priorities And Possibilities, Bipasha Baruah, Dina Najjar

Data and Test Instruments

The MENA region is both disproportionately vulnerable to compound climate fragility risks and among the most gender unequal regions in the world. Although we must be wary of over-generalizing about women’s needs and experiences across such a diverse set of geographic, ecological, cultural, socio-economic, political, and institutional contexts, the existing body of research on gender and climate change in MENA does enable us to comment reasonably certainly on what we know and what we do not know about the opportunities and challenges women experience in agriculture, the gendered effects and outcomes of climate change upon agriculture, and the roles women …

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First-Person Plural Indexicals, Robert Stainton, Arthur Sullivan Dec 2022

First-Person Plural Indexicals, Robert Stainton, Arthur Sullivan

Philosophy Publications

This is a study of an under-developed topic in philosophy of language, namely first-person plural pronouns (‘we’, ‘us’, etc.) Richard Vallee has made very important progress by identifying crucial desiderata and putting forward an ingenious proposal about ‘we’ which addresses them. We contend that, despite this impressive progress, he makes some missteps, both omissions and errors; furthermore, his proposal appears implausible as a personal-level psychological story. We thus sketch an alternative approach to the semantics of the first-person plural indexical which, though it builds on Vallee’s important work, departs substantially from it.

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Weight Of The World, Lauren Evans Dec 2022

Weight Of The World, Lauren Evans

The Prairie Light Review

No abstract provided.

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Lot 12, Nina Martinez, Special Collections, Fleet Library Dec 2022

Lot 12, Nina Martinez, Special Collections, Fleet Library

9th Baker & Whitehill Student Artists' Book Contest 2023

Entry for the 9th Annual Baker & Whitehill Student Artists' Book Contest. Opening Reception Thursday, March 02, 2023, Fleet Library, Main Reading Room. Juror: Andre Lee Bassuet.

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