Digital Commons Network^™

Coaches Supporting Teachers Reluctant To Implement Intervention Instruction: The Role Of Reflection, Elizabeth Cutrer, Erica E. Miller

Faculty Publications

No abstract provided.

250 E. Houston Invs. L.P. V. State Of N.Y. Div. Of Hous. & Community Renewal

All Decisions

No abstract provided.

Plasmon-Enhanced Quantitative Lateral Flow Assay For Detection Of Neisseria Gonorrhoeae, Jiaqi Wang

McKelvey School of Engineering Graduate Student Theses & Dissertations

（ng）感染是最常见的性传播感染（STI）之一2020年，CDC共677,769例淋病。。。常常因对抗对抗耐药性高度易受到受到困扰困扰。。。因此因此因此因此因此因此因此因此因此快速准确地地检测检测淋病淋病就尤为尤为重要重要淋病的，但其试验时间长费用高的特点为加强加强全球淋病淋病淋病淋病防治防治工作工作工作工作工作工作淋病淋病淋病淋病淋病淋病淋病淋病淋病淋病感染感染感染感染感染，研制淋病感染感染研制研制研制研制一种灵敏，，特异特异，，迫切需要需要发明发明是基石，它基石，廉价廉价敏感。这工作中中中中，我们我们项项，我们我们了了了了了一种所有所有所有所有所有所有所有所有。我们用等离子体光做为超亮光标记，以克服依赖传统金纳米颗粒做为比色标记的横向流动分析的有限度。

Impacts Of The Poultry Industry In Mississippi, Sara Watts

Master's Theses

This thesis examines the impacts of the poultry industry in seven counties in the Piney Woods region of South Mississippi: Wayne, Jones, Forrest, Lamar, Jefferson Davis, Marion, and Pike. Current research indicates that the poultry industry has a significant impact on the cultures and economies of rural towns throughout the United States. There is no current research that examines the effects of the poultry industry on residents of the Piney Woods. This thesis addresses that gap in the research and contributes to current understanding of how the industry molds and impacts the lives of those intimately associated with it.

I …

Finding Balance: A Content Analysis Of How Newspaper Authors Framed Simone Biles Before, During, And After The 2020 Olympic Games, Hadley Howell

Master's Theses

Simone Biles was considered the GOAT, Greatest of All Time, going into the 2020 Olympic Games. However, after the COVID-19 pandemic, the Larry Nassar trial, and the weight of the world on her shoulders, Biles would withdraw from the women’s gymnastics team final competition for mental health reasons. Thus, the following study examines how Biles was framed in the ten most circulated newspapers in the United States before, during, and after the 2020 Olympic Games. Results show that an author’s race and gender, topic of the article, type of article, and if an article contained an image or not ultimately …

Message Convergence In Information Seeking And Decision Making Among Adult Children Regarding Their Parent's Diagnosis, Collyn Leggett

Master's Theses

Adult children have a unique role in caregiving and decision-making for a parent diagnosed with a life-threatening illness or condition. In this qualitative study, 15 individuals participated in one-on-one interviews to share their experience seeking information for their parent’s life-threatening diagnosis. This study utilized deductive and inductive coding approaches through axial coding, and two coders analyzed the data through a lens of message convergence framework and uncertainty management. The results show participants engage in information seeking from personal connections to the medical field to retrieve additional information from a more familiar, trusted source. The participants managed uncertainty retrospectively by reassessing …

Militant Maids: Domestic Workers’ Participation In Bus Boycotts, Voter Registration, And Head Start Programs In The Deep South, Brittany Ann Carey

Master's Theses

This thesis examines the participation of domestic workers in the Civil Rights Movement, specifically in Gulf South bus boycotts in Baton Rouge, Montgomery, and Tallahassee; voter registration efforts in Mississippi, Louisiana, Alabama, and Florida; and Head Start work in those same Deep South states. Domestic workers engaged in activism by joining unions, women's movements, and the Communist Party to improve their treatment in Northern and Southern cities. Modern historians have expanded their research to explore the participation of domestic workers in the Civil Rights Movement, especially in the Montgomery Bus Boycott. In some cases, researchers also have explored the complicated …

Liggett V. Lew Realty Llc

All Decisions

No abstract provided.

351 Canal St. Llc V. New York State Div. Of Hous. & Community Renewal (Dhcr)

All Decisions

No abstract provided.

197 Madison Holdings Llc V. Nys Div. Of Hous. & Community Renewal

All Decisions

No abstract provided.

An Elf4 Hypomorphic Variant Results In Nk Cell Deficiency, Sandra Andrea Salinas, Emily M Mace, Matilde I Conte, Chun Shik Park, Yu Li, Joshua I Rosario-Sepulveda, Sanjana Mahapatra, Emily K Moore, Evelyn R Hernandez, Ivan K Chinn, Abigail E Reed, Barclay J Lee, Alexander Frumovitz, Richard A Gibbs, Jennifer E Posey, Lisa R Forbes Satter, Akaluck Thatayatikom, Eric J Allenspach, Theodore G Wensel, James R Lupski, H Daniel Lacorazza, Jordan S Orange

Faculty, Staff and Students Publications

NK cell deficiencies (NKD) are a type of primary immune deficiency in which the major immunologic abnormality affects NK cell number, maturity, or function. Since NK cells contribute to immune defense against virally infected cells, patients with NKD experience higher susceptibility to chronic, recurrent, and fatal viral infections. An individual with recurrent viral infections and mild hypogammaglobulinemia was identified to have an X-linked damaging variant in the transcription factor gene ELF4. The variant does not decrease expression but disrupts ELF4 protein interactions and DNA binding, reducing transcriptional activation of target genes and selectively impairing ELF4 function. Corroborating previous murine models …

Lpa Disruption With Aav-Crispr Potently Lowers Plasma Apo(A) In Transgenic Mouse Model: A Proof-Of-Concept Study, Alexandria M Doerfler, So Hyun Park, Julia M Assini, Amer Youssef, Lavanya Saxena, Adam B Yaseen, Marco De Giorgi, Marcel Chuecos, Ayrea E Hurley, Ang Li, Santica M Marcovina, Gang Bao, Michael B Boffa, Marlys L Koschinsky, William R Lagor

Faculty, Staff and Students Publications

Lipoprotein(a) (Lp(a)) represents a unique subclass of circulating lipoprotein particles and consists of an apolipoprotein(a) (apo(a)) molecule covalently bound to apolipoprotein B-100. The metabolism of Lp(a) particles is distinct from that of low-density lipoprotein (LDL) cholesterol, and currently approved lipid-lowering drugs do not provide substantial reductions in Lp(a), a causal risk factor for cardiovascular disease. Somatic genome editing has the potential to be a one-time therapy for individuals with extremely high Lp(a). We generated an LPA transgenic mouse model expressing apo(a) of physiologically relevant size. Adeno-associated virus (AAV) vector delivery of CRISPR-Cas9 was used to disrupt the LPA transgene in …

Trends In Esophageal Adenocarcinoma And Esophageal Squamous Cell Carcinoma Incidence In The United States From 1992 To 2019, Kyle S Liu, Syed Ahsan Raza, Hashem B El-Serag, Aaron P Thrift

Faculty, Staff and Students Publications

Simple Summary

The incidence of esophageal cancer overall has increased in the United States, driven by increasing rates of esophageal adenocarcinoma (EAC). However, whether rates of EAC are still rising is unclear. We examined trends in esophageal cancer overall and within important sub-groups of the population. We found that esophageal squamous cell carcinoma (ESCC) rates have been steadily declining, while EAC rates rose rapidly before stabilizing in 2000. The trend of decreasing incidence of ESCC was observed almost uniformly by age group, sex, and race/ethnicity, while trends in EAC rates varied across these sub-groups. A cohort effect for EAC was …

The Coptic Orthodox Church: The Balance Of Its Continuation Of Its 1st Century Roots And Its Adaptation To Modernity, Meri Souliman

History Theses

This thesis analyzes the survival of the Coptic Orthodox Church and argues that the Church has effectively adapted to modernity. This survival and adaptation of this 1st century Church is argued for in the transformation and adaptation of language, the role of women, the practices of Coptic monasticism, and the creation of a new modern phenomena, the Coptic diasporic community, mainly though the example of the United States. The analyses presented are drawn from both primary and secondary sources that effectively ague for both the survival and adaptation of the Coptic Church. Finally, this thesis thus provides an institutional history …

A Miniature And Low-Power Potentiostat For Integration With Wearable Sensors, Franci Franulovic

Electrical Engineering Theses

The potentiostat is an analytical device and an important part of an electrochemical instrument commonly used in electrochemical experiments to investigate chemical reaction mechanisms and other chemical phenomena. The ability to detect chemical phenomena can be useful for early disease detection. Nowadays conventional potentiostats are designed as benchtop instruments for use in laboratory environments. In contrast, a wearable potentiostat is designed to interface with wearable biochemical sensors for disease diagnostics. This thesis reports a wearable potentiostat that is designed for interfacing with a sensor array (eight to ten working electrodes). The system is battery-powered using lithium-ion batteries. The data is …

Fedex Ground Strategic Audit, Samantha Gates

Honors Program: Senior Projects (Public)

FedEx Ground is an operating segment of the parcel carrier giant FedEx Inc. The company, known for shipping products via delivery truck, has remained one of the largest parcel carriers in the country, despite drastic changes in its environment. This report seeks to understand the changing operating environment of FedEx Ground, its competitive advantages, and the future challenges it may face. The analysis uses PESTEL and Porter's Five Forces analyses to evaluate the changing external environment and industry FedEx Ground operates in. Additionally, challenges and recommendations are offered to navigate the future of this company.

Spatial Variability Of Greenhouse Gases In Blue Carbon Mangrove Ecosystems, Jordan Page

All HCAS Student Capstones, Theses, and Dissertations

Blue carbon ecosystems, including mangrove forests, play a vital role in the global carbon cycle through their carbon sequestration and storage capabilities. Mangrove trees remove CO2 from the atmosphere and store it within these ecosystems. Buildup of organic matter also contributes to high production of methane that is eventually released to adjacent coastal systems and to the atmosphere through air sea gas exchange. It is necessary to investigate environmental conditions that drive greenhouse gas fluctuations to understand how they will change due to climate change and ocean acidification impacts. The goal of this study is to investigate the spatial variability …

Episode 24: Wrapping Up Season 3 And Looking Ahead To Season 4, Christina Torres

Futures in Languages Transcripts

No abstract provided.

The Effects Of Strength, Flexibility, And Aerobic Training On The Management And Improvement Of Symptoms Of Fibromyalgia In Women: A Systematic Review., Lainey Whittle

Honors Theses

No abstract provided.

The Design, Synthesis, And Investigation Into Small Molecule Modulators Of The Src Homology 2 Domain-Containing Inositol 5’-Phosphatase (Ship), Shea Thomas Meyer

Dissertations - ALL

The PI3K pathway is a major cell signaling pathway that influences survival and longevity in eukaryotic cells. Abnormal signaling of this pathway has been implicated in a number of disorders, including Alzheimer's disease and cancer. The PI3K pathway utilizes the inositolphospholipid PI(3,4,5)P3 as a key secondary messenger in the transmission of signals from outside the cell to the nucleus. The SRC Homology 2 containing Inositol 5’-Phosphatase (SHIP) also plays a key role in the PI3K pathway, mediating hydrolysis of the inositol phospholipid PI(3,4,5)P3 to PI(3,4)P2. Early testing has shown modulation of SHIP activity through the use of small molecule modulators …

Do Adverse Childhood Experiences Increase The Likelihood Of High School Suspension?, Ashley Kernan, Melissa Jones, Hayley Pierce

FHSS Mentored Research Conference

Scholars have found that adverse childhood experiences (ACEs) are associated with a wide variety of negative health and behavior outcomes during adolescence. However, significantly less research has examined how ACEs may influence the risk of being suspended from school during high school. Thus, the purpose of this study is to examine the relationship between cumulative, cluster and individual adverse childhood experiences (ACEs) and high school suspension. Data comes from the 2022 Florida Youth Substance Abuse Survey (FYSAS). The sample consists of 23,078 high schoolers from grades 9-12^th. Logistic regressions were run to examine the association between ACEs and …

Biological Remediation Of Fragipan, Corey Hale

Honors College Theses

The fragipan layer in the soil is a naturally occurring subsurface layer that restricts water percolation as well as inhibits root growth. A fragipan layer can be found almost ubiquitously across Southwestern Kentucky. This limits how agriculturalists manage soils in this area. It has been recently discovered by the University of Kentucky that Annual Ryegrass roots produce 3,4 dihydroxyphenylpropionic acid (DHPPA) that reacts with this hardpan to weaken the layer. Certain bacteria, such as Escherichia coli, Lactobacilli, and Bifidobacteria can also synthesize DHPPA through a breakdown process of chlorogenic acid. This reaction typically happens in the human digestive tract. …

Determinism Beyond Time Evolution, Emily Adlam

Mathematics, Physics, and Computer Science Faculty Articles and Research

Physicists are increasingly beginning to take seriously the possibility of laws outside the traditional time-evolution paradigm; yet many popular definitions of determinism are still predicated on a time-evolution picture, making them manifestly unsuited to the diverse range of research programmes in modern physics. In this article, we use a constraint-based framework to set out a generalization of determinism which does not presuppose temporal evolution, distinguishing between strong, weak and delocalised holistic determinism. We discuss some interesting consequences of these generalized notions of determinism, and we show that this approach sheds new light on the long-standing debate surrounding the nature of …

Whole Genome Sequencing Identifies Structural Variants Contributing To Hematologic Traits In The Nhlbi Topmed Program, Marsha M. Wheeler, Adrienne M. Stilp, Shuquan Rao, Bjarni V. Halldórsson, Doruk Beyter, Jia Wen, Anna V. Mihkaylova, Laura Almasy, John Blangero, Joanne E. Curran

School of Medicine Publications

Genome-wide association studies have identified thousands of single nucleotide variants and small indels that contribute to variation in hematologic traits. While structural variants are known to cause rare blood or hematopoietic disorders, the genome-wide contribution of structural variants to quantitative blood cell trait variation is unknown. Here we utilized whole genome sequencing data in ancestrally diverse participants of the NHLBI Trans Omics for Precision Medicine program (N = 50,675) to detect structural variants associated with hematologic traits. Using single variant tests, we assessed the association of common and rare structural variants with red cell-, white cell-, and platelet-related quantitative …

Exploring The Effectiveness Of The Grizzly Success Program At Georgia Gwinnett College: A Quantitative Study, Michael Phillip Poll

Theses and Dissertations

Research suggests that summer bridge programs are a successful strategy for helping at-risk students succeed in college by offering additional tutoring, mentoring, and advising (Slade et al., 2015). Bridge programs are effective for increasing student success (Bir & Myrick, 2015). However, summer bridge programs may challenge at-risk first-generation students due to limited access and additional fees (Mullen, 2010). The additional costs associated with summer programs combined with the summertime commitment needed for summer bridge programs may present a barrier to enrollment and prove difficult for at-risk students to overcome. Grizzly Success is a program that provides additional academic support, social …

A Way Forward After Dobbs: Human Rights Advocacy And Self-Managed Abortion In The United States, Kelly Keglovits

Duke Journal of Constitutional Law & Public Policy Sidebar

Even in the era before Dobbs, wherein the Supreme Court repeatedly classified abortion as a "fundamental right," the ability to have an abortion was inaccessible in many parts of the United States. The irony that a "fundamental right" was so difficult to exercise results from how Constitutional rights are understood, which left many open-ended avenues for states to bring restrictions. International Human Rights law, however, offers a more optimistic and accountable approach to steps forward in increasing abortion access—illustrating a need to bring a human rights-based approach home. Dobbs has eviscerated any concept of federal protections for abortion, severely worsening …

Multifrequency Scintillation In The Polar Caps, Tate Colby

Doctoral Dissertations and Master's Theses

In the ionosphere, plasma density structures with scales sizes ranging from a few centimeters to hundreds of kilometers are capable of modifying the phase and amplitude of a radio signal in a rapid random manner in a process called scintillation. The Coherent Electromagnetic Radio Tomography (CERTO) and the Canadian High Arctic Ionospheric Network (CHAIN) are two different networks of scintillation receivers, each with a station in Resolute Bay, Canada. CERTO measures amplitude and phase signals in VHF and UHF while CHAIN measures amplitude and phase signals in the L-band. Through these measurements we can calculate the scintillation indexes, S_4 and …

Development And Deployment Of A Dynamic Soaring Capable Uav Using Reinforcement Learning, Jacob Adamski

Doctoral Dissertations and Master's Theses

Dynamic soaring (DS) is a bio-inspired flight maneuver in which energy can be gained by flying through regions of vertical wind gradient such as the wind shear layer. With reinforcement learning (RL), a fixed wing unmanned aerial vehicle (UAV) can be trained to perform DS maneuvers optimally for a variety of wind shear conditions. To accomplish this task, a 6-degreesof- freedom (6DoF) flight simulation environment in MATLAB and Simulink has been developed which is based upon an off-the-shelf unmanned aerobatic glider. A combination of high-fidelity Reynolds-Averaged Navier-Stokes (RANS) computational fluid dynamics (CFD) in ANSYS Fluent and low-fidelity vortex lattice (VLM) …

Approval Letter For The Revised Residential Metals Abatement Program (Rmap), Interior School Soils Remedial Action Work Plan (Rawp), Butte High School (Dated November 17, 2022), Nikia Greene

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Genetic Expression Changes And Pathologic Findings Associated With Hyperhomocysteinemia In Human Autopsy Brain Tissue, Erica M. Weekman, Zachary Winder, Colin B. Rogers, Erin L. Abner, Tiffany L. Sudduth, Ela Patel, Adam J. Dugan, Shuling X. Fister, Brandi Wasek, Peter T. Nelson, Gregory A. Jicha, Teodoro Bottiglieri, David W. Fardo, Donna M. Wilcock

Sanders-Brown Center on Aging Faculty Publications

Introduction: Vascular contributions to cognitive impairment and dementia (VCID) are a leading cause of dementia. An underappreciated, modifiable risk factor for VCID is hyperhomocysteinemia (HHcy), defined by elevated levels of plasma homocysteine, most often due to impaired B vitamin absorption in aged persons. Studies aimed at identifying neuropathologic features and gene expression profiles associated with HHcy have been lacking.

Methods: A subset of research volunteers from the University of Kentucky Alzheimer’s Disease Research Center longitudinal cohort came to autopsy and had ante mortem plasma homocysteine levels available. Brain tissue and blood plasma drawn closest to death were used to measure …