Digital Commons Network^™

Layout And Suggestions On China’S Science And Technology Innovation Centers At Different Levels, Wenzhong Zhang

Bulletin of Chinese Academy of Sciences (Chinese Version)

Science and technology innovation center plays an important role in transforming the mode of economic development and enhancing industrial competitiveness. The formation and development of science and technology innovation center depend on the gathering of innovative talents, the support of first-rate universities and research institutions, and the cooperation and mutual promotion between innovation organizations and enterprises. In the course of future development, China should build a multi-level network system of science and technology innovation centers with international centers which can connect to global innovation networks, national centers which are capable of leading national science and technology research and development and …

Digitalization Of National Industrial Clusters In China: Estimation From Online Industrial Belts, Zuoquan Zhao, Yichang Dai, Qiuci Fan, Shuyan Ma

Bulletin of Chinese Academy of Sciences (Chinese Version)

Digitalized industrial cluster is the new development trend of China’s digital economy. This study estimates the extent of digitalization of national industrial clusters in China, by using spatial statistics, visualization techniques, and cluster-belt matching, with data on clusters promoted by the National Development and Reform Commission, Ministry of Industry and Informalization Technology, and Ministry of Science and Technology, and on-line industrial belts (2021) developed by Alibaba Group. The estimation finds that both the national clusters and on-line industrial belts co-existed in 72 cities, which account for 91.1 percent of the cities with national clusters; 134 or 84.3 percent of the …

Ecological Green Integration In Yangtze River Delta From Perspective Of Intercity Green Technology Transfer, Debin Du, Hong Jin, Dezhong Duan

Bulletin of Chinese Academy of Sciences (Chinese Version)

Green technology innovation is the core driving force for the high-quality development of regional integration in the Yangtze River Delta, and the free flow of innovative elements represented by green technology across cities is the due meaning of the construction of ecological green integration in the Yangtze River Delta. Based on the inter-city green patent transfer data from 2001 to 2020, this study analyzed the characteristics of the spatial evolution of green technology diffusion in the Yangtze River Delta, and discussed the development degree of ecological green integration in the area from the three levels of overall development, green technology …

Strategic Thoughts On Reconstruction Of State Key Laboratories Under New Nationwide System, Ninghui Sun

Bulletin of Chinese Academy of Sciences (Chinese Version)

The allocation of science and technology resources and the organization of science and technology forces, which has always been connected intrinsically with the nation’s development, has adopted different models, undertaken different missions, and played different roles in different stages of the development. This paper conducts a review and analysis on the major challenges faced by the nation, assignment of scientific tasks, organization of science and technology forces, and the output of scientific achievements, from the perspectives of “from standing upright to becoming prosperous and growing in strength”. It aims to provide a deep understanding of the nation’s focus on the …

Policy Overview (November, 2022)

Bulletin of Chinese Academy of Sciences (Chinese Version)

No abstract provided.

Cover 2

Bulletin of Chinese Academy of Sciences (Chinese Version)

No abstract provided.

Correlations Between Complex Human Phenotypes Vary By Genetic Background, Gender, And Environment, Michael Elgart, Matthew O Goodman, Carmen Isasi, Han Chen, Alanna C Morrison, Paul S De Vries, Huichun Xu, Ani W Manichaikul, Xiuqing Guo, Nora Franceschini, Bruce M Psaty, Stephen S Rich, Jerome I Rotter, Donald M Lloyd-Jones, Myriam Fornage, Adolfo Correa, Nancy L Heard-Costa, Ramachandran S Vasan, Ryan Hernandez, Robert C Kaplan, Susan Redline, Tamar Sofer

Faculty, Staff and Student Publications

We develop a closed-form Haseman-Elston estimator for genetic and environmental correlation coefficients between complex phenotypes, which we term HEc, that is as precise as GCTA yet ∼20× faster. We estimate genetic and environmental correlations between over 7,000 phenotype pairs in subgroups from the Trans-Omics in Precision Medicine (TOPMed) program. We demonstrate substantial differences in both heritabilities and genetic correlations for multiple phenotypes and phenotype pairs between individuals of self-reported Black, Hispanic/Latino, and White backgrounds. We similarly observe differences in many of the genetic and environmental correlations between genders. To estimate the contribution of genetics to the observed phenotypic correlation, we …

Menstrual Health Among Adolescents And Young Adults In Rural Haiti., Emily R. Rupe, Jonathan Rodean, Emily A. Hurley, Melissa K. Miller, Marie Daphnee Boncoeur, Abbey R. Masonbrink

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Adolescent and young adult (AYA) females in low- and middle-income countries often face disparities in menstrual health (MH). Poor MH and lack of sexual and reproductive health education leads to school absenteeism, increasing risk for adverse psychosocial and educational outcomes. Further, disasters (e.g., earthquakes) are linked with unsafe living environments and sanitation facilities for women. We sought to describe MH perspectives and practices among AYAs in rural Haiti.

METHODS: We conducted a cross-sectional survey in two rural communities in Haiti. AYA females aged 14-24 years completed questions on demographics, the Menstrual Practice Needs Scale (36 items; MPNS-36) and the …

Xcvatr: Detection And Characterization Of Variant Impact On The Embeddings Of Single -Cell And Bulk Rna-Sequencing Samples, Arif Harmanci, Akdes Serin Harmanci, Tiemo J Klisch, Akash J Patel

Duncan NRI Faculty and Staff Publications

Background: RNA-sequencing has become a standard tool for analyzing gene activity in bulk samples and at the single-cell level. By increasing sample sizes and cell counts, this technique can uncover substantial information about cellular transcriptional states. Beyond quantification of gene expression, RNA-seq can be used for detecting variants, including single nucleotide polymorphisms, small insertions/deletions, and larger variants, such as copy number variants. Notably, joint analysis of variants with cellular transcriptional states may provide insights into the impact of mutations, especially for complex and heterogeneous samples. However, this analysis is often challenging due to a prohibitively high number of variants and …

Labial Frenotomy For Symptomatic Isolated Upper Lip Tie, Cecilia G Freeman, Jason F Ohlstein, Nicholas A Rossi, John B Mcintire, Luis D Neve, Shiva Daram, Harold S Pine

Faculty, Staff and Student Publications

BACKGROUND: The benefits and challenges of successful breastfeeding for both mother and child have been well-established in the literature. While ankyloglossia, or tongue tie, alone or in combination with upper lip tie has been the focus of several previous studies, very few have directly addressed isolated symptomatic upper lip tie and the role of surgical correction for breastfeeding difficulties.

MATERIALS AND METHODS: Seven infants with isolated upper lip tie and breastfeeding difficulty were taken to the operating room for labial frenotomy. These infants were assessed at their follow-up visits for their degree of weight gain since their procedure. Their mothers …

Spatial Heterogeneity Of Infiltrating T Cells In High-Grade Serous Ovarian Cancer Revealed By Multi-Omics Analysis, Bin Yang, Xiong Li, Wei Zhang, Junpeng Fan, Yong Zhou, Wenting Li, Jingjing Yin, Xiaohang Yang, Ensong Guo, Xi Li, Yu Fu, Si Liu, Dianxing Hu, Xu Qin, Yingyu Dou, Rourou Xiao, Funian Lu, Zizhuo Wang, Tianyu Qin, Wei Wang, Qinghua Zhang, Shuaicheng Li, Ding Ma, Gordon B Mills, Gang Chen, Chaoyang Sun

Faculty, Staff and Student Publications

Tumor-infiltrating lymphocytes (TILs), especially CD8+ TILs, represent a favorable prognostic factor in high-grade serous ovarian cancer (HGSOC) and other tumor lineages. Here, we analyze the spatial heterogeneity of different TIL subtypes in HGSOC. We integrated RNA sequencing, whole-genome sequencing, bulk T cell receptor (TCR) sequencing, as well as single-cell RNA/TCR sequencing to investigate the characteristics and differential composition of TILs across different HGSOC sites. Two immune "cold" patterns in ovarian cancer are identified: (1) ovarian lesions with low infiltration of mainly dysfunctional T cells and immunosuppressive Treg cells and (2) omental lesions infiltrated with non-tumor-specific bystander cells. Exhausted CD8 T …

Structural Insights Into Cardiolipin Replacement By Phosphatidylglycerol In A Cardiolipin-Lacking Yeast Respiratory Supercomplex, Elena G Govorunova, Oleg A Sineshchekov, Leonid S Brown, Ana-Nicoleta Bondar, John L Spudich

Faculty, Staff and Student Publications

Potassium-selective channelrhodopsins (KCRs) are light-gated K+ channels recently found in the stramenopile protist Hyphochytrium catenoides. When expressed in neurons, KCRs enable high-precision optical inhibition of spiking (optogenetic silencing). KCRs are capable of discriminating K+ from Na+ without the conventional K+ selectivity filter found in classical K+ channels. The genome of H. catenoides also encodes a third paralog that is more permeable for Na+ than for K+. To identify structural motifs responsible for the unusual K+ selectivity of KCRs, we systematically analyzed a series of chimeras and mutants of this protein. We found that mutations of three critical residues in the …

Emergency Remote Teaching Versus Planned Remote Teaching: Narrowing The Gap With Targeted Professional Development, Bonnie J. Covelli, Sudipta Roy

Higher Learning Research Communications

Objectives: This study reviews faculty members’ comfort level with remote teaching in the Fall 2020 semester to evaluate the effectiveness of the professional development workshops.

Method: Using survey research, we examined professional development activities and subsequent comfort level and ease of adjustment with remote teaching in Fall 2020.

Results: Following the training, faculty reported high planned usage of various online teaching tools and great comfort with using them. The data reveals some differences between part-time and full-time faculty members.

Conclusions: The experience gained in the emergency semester, combined with the targeted professional development workshops offered eased the stress of planned …

In-Depth Analysis Of Alternative Splicing Landscape In Multiple Myeloma And Potential Role Of Dysregulated Splicing Factors, Anil Aktas Samur, Mariateresa Fulciniti, Herve Avet-Loiseau, Michael A Lopez, Sanika Derebail, Jill Corre, Stephane Minvielle, Florence Magrangeas, Philippe Moreau, Kenneth C Anderson, Giovanni Parmigiani, Mehmet K Samur, Nikhil C Munshi

Faculty, Staff and Student Publications

Splicing changes are common in cancer and are associated with dysregulated splicing factors. Here, we analyzed RNA-seq data from 323 newly diagnosed multiple myeloma (MM) patients and described the alternative splicing (AS) landscape. We observed a large number of splicing pattern changes in MM cells compared to normal plasma cells (NPC). The most common events were alterations of mutually exclusive exons and exon skipping. Most of these events were observed in the absence of overall changes in gene expression and often impacted the coding potential of the alternatively spliced genes. To understand the molecular mechanisms driving frequent aberrant AS, we …

A Classical Model Of Speculative Asset Price Dynamics, Sabiou M. Inoua, Vernon L. Smith

ESI Working Papers

In retrospect, the experimental findings on competitive market behavior called for a revival of the old, classical, view of competition as a collective higgling and bargaining process (as opposed to price-taking behaviors) founded on reservation prices (in place of the utility function). In this paper, we specialize the classical methodology to deal with speculation, an important impediment to price stability. The model involves typical features of a field or lab asset market setup and lends itself to an experimental test of its specific predictions; here we use the model to explain three general stylized facts, well established both empirically and …

Perspectives On Joint Eanm/Snmmi/Anzsnm Practice Guidelines/Procedure Standards For [18f]Fdg Pet/Ct Imaging During Immunomodulatory Treatments In Patients With Solid Tumors, E Lopci, R L Wahl, Et Al.

2020-Current year OA Pubs

Response assessment in the context of immunomodulatory treatments represents a major challenge for the medical imaging community and requires a multidisciplinary approach with involvement of oncologists, radiologists, and nuclear medicine specialists. There is evolving evidence that [

Table Of Contents

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

Table of Contents

Swot Analysis Of Investing In Cryptocurrencies, Justyna Ziobrowska

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

The purpose of this article is to discuss the strengths and weaknesses of investing in cryptocurrencies, and to indicate the prospects for further developments of the cryptocurrency market in the world. In terms of methodology, the paper provides an analysis and criticism of literature as well as research and inference of document. The analysis carried out indicates that investing in cryptocurrencies is risky but, at the same time, it offers a potentially good chance for a high return on investment. Cryptocurrencies have very large price fluctuations and are able to generate both severe losses and huge rates of return, unheard …

Plans To Raise The Level Of Consumer Protection As Retail Investors In Eu Law, Piotr Gałązka

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

In light of the European Commission’s announcement of May 2022 of new legislative work aimed at raising the level of consumer protection in the capital market when consumers act in the capacity of a retail investor, the article considers the planned measures, evaluating them through the prism of calls for regulatory changes, pointing out the most relevant needs and the most pressing problems. The analysis is based on previous reports, as well as national solutions in some EU member states. In particular, attention is paid to the need to simplify the EU legal system for retail investors, to increase transparency …

Bond Tokenization – Comments On The Background Of Art. 8 Sec. 2 Of The Act Of January 15th, 2015 On Bonds, Paweł Czaplicki

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

The article discusses the issue of the ‘tokenization’ of bonds in Poland. Presented are also de lege ferenda postulates concerning the implementation of this process in the domestic legal conditions. The article uses the dogmatic and legal research method. The main research problem presented in the article is whether the tokenization of bonds in Poland is possible. In accordance with the hypothesis put forward by the author, the legal regulations in force in this area currently prevent the tokenization of bonds in Poland.

Review Of Judicial Case Law On Practices Violating The Collective Interests Of Consumers Concerning The Financial Market In The First Half Of 2022, Łukasz Wroński

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

This review discusses selected court rulings concerning the financial market (made in the first half of 2022) after the President of UOKiK (the Office of Competition and Consumer Protection) issued decisions in cases of practices that violate the collective interests of consumers. The study presents the most significant motives of the rulings of the District Court in Warsaw – SOKiK (the Court of Competition and Consumer Protection), the Court of Appeals in Warsaw and the Polish Supreme Court.

Review Of Anti-Consumer Market Practices Concerning Financial Services In Light Of The Decisions Of The President Of Uokik Issued In 2022, Edyta Rutkowska-Tomaszewska, Artur Zwaliński

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

This paper reviews the decisions of the President of UOKiK (President of the Office of Competition and Consumer Protection) issued during the period from January 1st to December 31st, 2022. All decisions issued by the President of UOKiK during the indicated period were analyzed and evaluated. They were divided into two main categories based on the UOKiK President’s jurisdiction to issue decisions on anti-consumer market practices; first: decisions on violations of collective consumer interests, and, second, decisions on the use of prohibited contractual provisions in model contract templates. They were then further divided, within the two above categories, into groups …

Krzysztof Waliszewski (Ed.), Personal Finance, Polish Academy Of Sciences Publishing House, Warsaw 2022, Pp. 426, Iwona D. Czechowska

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

A review of a book edited by Krzysztof Waliszewski.

Piotr Łasak (Ed.), Identity Of Banks In The Face Of Financial Technology Development, Jagiellonian University Publishing House, Kraków 2021, Pp. 146, Krzysztof Waliszewski

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

A review of a book edited by Piotr Łasak.

Entire Issue Vol. 11 No. 7

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

Vol 11(7)

Highly Power Dense Dc To Three-Phase Ac Modular Converters With Tiny Module Capacitors, Wiwin Hartini Lew

Dissertations and Theses

A Modular Multilevel Converter (MMC) is an attractive candidate in high power conversion due to its modularity and scalability. The energy storage element, namely the module capacitance in the MMC submodule circuit, is typically large and when scaled to convert high power, requires very bulky module capacitors. In addition to deteriorating the power density, the design necessitates the use of electrolytic capacitors, which further affects the overall converter efficiency and reliability. This research presents an MMC submodule topology and the accompanying modulation approach that reduces the submodule capacitance requirements significantly compared to conventional MMC topology (few micro-farads versus several milli-farads). …

Magnetized Inulin By Fe3o4 As A Bio-Nano Adsorbent For Treating Water Contaminated With Methyl Orange And Crystal Violet Dyes, Kamran Valizadeh, Amir Bateni, Nazanin Sojoodi, Maryam Rostami Ataabadi, Amir Hossein Behroozi, Ali Maleki, Zhenjiang You

Research outputs 2022 to 2026

Current work focuses on fabricating a new bio-nano adsorbent of Fe₃O₄@inulin nanocomposite via an in-situ co-precipitation procedure to adsorb methyl orange (MO) and crystal violet (CV) dyes from aqueous solutions. Different physical characterization analyses verified the successful fabrication of the magnetic nanocomposite. The adsorbent performance in dye removal was evaluated by varying initial dye concentration, adsorbent dosage, pH and temperature in 5110 mg/L, 0.10.8 g/L, 111 and 283 – 338 K, respectively. Due to the pH of zero point of charge and intrinsic properties of dyes, the optimum pHs were 5 and 7 for MO and …

Self-Hybridization In Leishmania Major, Tiago R Ferreira, Ehud Inbar, Jahangheer Shaik, Brendan M Jeffrey, Kashinath Ghosh, Deborah E. Dobson, Stephen M. Beverley, David Sacks

2020-Current year OA Pubs

Genetic exchange between different

Comparison Of Endoscopic Thyroidectomy By Complete Areola Approach And Conventional Open Surgery In The Treatment Of Differentiated Thyroid Carcinoma: A Retrospective Study And Meta-Analysis, Yuquan Yuan, Chenyu Sun, Tingjie Yin, Cong Shao, Bin Pan, Dengwei Lu, Shaodong Hou, Scott Lowe, Rachel Bentley, Shuya Chen, Christy Huang, Ce Cheng, Yaru Li, Bethany King, Qin Zhou, Cunye Yan, Fan Zhang

Student Publications

Background: The feasibility of endoscopic thyroidectomy by complete areola approach (ETCA) remains controversial. This study was conducted by combining our clinical data with the data obtained from a systematic review literature search to examine the effectiveness and safety of ETCA compared with conventional open thyroidectomy (COT) in differentiated thyroid carcinoma (DTC).

Methods: A total of 136 patients with a diagnosis of DTC who underwent unilateral thyroidectomy with central neck dissection from August 2020 to June 2021 were enrolled. The enrolled patients were divided into the ETCA group (n = 73) and the COT group (n = 63). The …

Morphologic Design Of Nanostructures For Enhanced Antimicrobial Activity, Fatma Al-Zahraa Sayed, Noura G Eissa, Yidan Shen, David A Hunstad, Karen L Wooley, Mahmoud Elsabahy

2020-Current year OA Pubs

Despite significant progress in synthetic polymer chemistry and in control over tuning the structures and morphologies of nanoparticles, studies on morphologic design of nanomaterials for the purpose of optimizing antimicrobial activity have yielded mixed results. When designing antimicrobial materials, it is important to consider two distinctly different modes and mechanisms of activity-those that involve direct interactions with bacterial cells, and those that promote the entry of nanomaterials into infected host cells to gain access to intracellular pathogens. Antibacterial activity of nanoparticles may involve direct interactions with organisms and/or release of antibacterial cargo, and these activities depend on attractive interactions and …