Digital Commons Network^™

Magnetic Nanoparticles Coated With Zwitterionic Copolymer As An Advanced Material For Rapid And Instrument-Free Biomolecular Detection In Human Serum, Supannika Boonjamnian, Varunee Sadsri, Voravee P. Hoven, Piyaporn Na Nongkhai

Journal of Metals, Materials and Minerals

The traditional agglutination assays especially those based on polystyrene beads have been recognized as convenient tools for disease diagnosis despite their limited detection range and low sensitivity. Unlike other particles namely polystyrene beads, SiO2 and gold nanoparticles having insignificant magnetic properties, magnetic nanoparticles (MNPs) offer unique advantages as their magnetic properties for agglutination methods. In the presence of magnet, not only can they be used to enrich the samples, but also their aggregation can also be induced, providing sensitive and rapid measurements. This work aims to develop MNPs for aggregation-based biomolecular detection. The MNPs were surface-modified with PMAMPC via an …

Erratum To: In Search For Near-Room-Temperature Superconducting Critical Temperature Of Metal Superhydrides Under High Pressure: A Review, Udomsilp Pinsook

Journal of Metals, Materials and Minerals

No abstract provided.

Higher Amyloid Is Associated With Greater Loneliness Among Cognitively Normal Older Adults During The Covid-19 Pandemic [Version 2; Peer Review: 2 Approved], Abigail Kehrer-Dunlap, Rebecca Bollinger, Szu-Wei Chen, Audrey Keleman, Regina Thompson, Anne Fagan, Beau Ances, Susan Stark

2020-Current year OA Pubs

BACKGROUND: Loneliness has been associated with several consequences, including increased risk of developing Alzheimer disease (AD). Loneliness may arise during the preclinical phase of AD, but little is known about the relationship between loneliness and amyloid accumulation consistent with preclinical AD. Therefore, the purpose of this study was to examine the relationship between amyloid accumulation and subjective experiences of loneliness among cognitively normal older adults during the COVID-19 pandemic.

METHODS: A global Clinical Dementia Rating

RESULTS: The 108 participants had a mean age of 75.0 and an average amyloid accumulation of 22.2 ± 31.9. Mean UCLA Loneliness Scale scores were …

It Is Time To Define An Organizational Model For The Prevention And Management Of Infections Along The Surgical Pathway: A Worldwide Cross-Sectional Survey, Massimo Sartellli, John E. Mazuski, Et Al.

2020-Current year OA Pubs

No abstract provided.

Job-Exposure Matrix: A Useful Tool For Incorporating Workplace Exposure Data Into Population Health Research And Practice, Alexis Descatha, Marc Fadel, Grace Sembajwe, Susan Peters, Bradley A Evanoff

2020-Current year OA Pubs

Workplace exposures to physical, chemical, and psychosocial factors account for a large burden of chronic diseases. Obtaining useful estimates of current and past workplace exposures is challenging, particularly in large general population studies. Job-exposure matrices (JEMs) are a useful tool for exposure assessment, particularly when no individual level exposure data are available. A JEM provides a cross-tabulation of job titles (sometimes combined with industry) and estimated exposures to workers carrying out these jobs during different time periods. The major limitation of JEMs is that they do not account for individual variation in exposures within the same job. This limitation is …

Preclinical Antibody-Pet Imaging Of Pd-L1, Emma L Brown, Rachel A Deweerd, Abbey Zidel, Patricia M R Pereira

2020-Current year OA Pubs

Programmed cell death protein-1/ligand-1 (PD-1/PD-L1) blockade, including antibody therapeutics, has transformed cancer treatment. However, a major challenge in the field relates to selecting patients who are likely to respond to immune checkpoint inhibitors. Indeed, biopsy-based diagnostic tests to determine immune checkpoint protein levels do not accurately capture the inherent spatial and temporal heterogeneity of PD-L1 tumor expression. As a result, not all PD-L1-positive tumors respond to immunotherapies, and some patients with PD-L1-negative tumors have shown clinical benefits. In 2018, a first-in-human study of the clinically-approved anti-PD-L1 antibody Atezolizumab labeled with the positron emitter zirconium-89 validated the ability of positron emission …

A Map Of Neurofilament Light Chain Species In Brain And Cerebrospinal Fluid And Alterations In Alzheimer's Disease, Melissa M Budelier, Yingxin He, Nicolas R Barthelemy, Hong Jiang, Yan Li, Ethan Park, Rachel L Henson, Suzanne E Schindler, David M Holtzman, Randall J Bateman

2020-Current year OA Pubs

Neurofilament light is a well-established marker of both acute and chronic neuronal damage and is increased in multiple neurodegenerative diseases. However, the protein is not well characterized in brain tissue or body fluids, and it is unknown what neurofilament light species are detected by commercial assays and whether additional species exist. We developed an immunoprecipitation-mass spectrometry assay using custom antibodies targeting various neurofilament light domains, including antibodies targeting Coil 1A/1B of the rod domain (HJ30.13), Coil 2B of the rod domain (HJ30.4) and the tail region (HJ30.11). We utilized our assay to characterize neurofilament light in brain tissue and CSF …

Differentiating Amyloid Beta Spread In Autosomal Dominant And Sporadic Alzheimer's Disease, Elizabeth Levitis, Jacob W Vogel, Thomas Funck, Vladimir Hachinski, Serge Gauthier, Jonathan Vöglein, Johannes Levin, Brian A Gordon, Tammie Benzinger, Yasser Iturria-Medina, Alan C Evans, Dominantly Inherited Alzheimer Network, Alzheimer’S Disease Neuroimaging Initiative

2020-Current year OA Pubs

Amyloid-beta deposition is one of the hallmark pathologies in both sporadic Alzheimer's disease and autosomal-dominant Alzheimer's disease, the latter of which is caused by mutations in genes involved in amyloid-beta processing. Despite amyloid-beta deposition being a centrepiece to both sporadic Alzheimer's disease and autosomal-dominant Alzheimer's disease, some differences between these Alzheimer's disease subtypes have been observed with respect to the spatial pattern of amyloid-beta. Previous work has shown that the spatial pattern of amyloid-beta in individuals spanning the sporadic Alzheimer's disease spectrum can be reproduced with high accuracy using an epidemic spreading model which simulates the diffusion of amyloid-beta across …

Multiple Conserved States Characterize The Twist Landscape Of The Bacterial Actin Homolog Mreb, Benjamin D Knapp, Michael D Ward, Gregory R Bowman, Handuo Shi, Kerwyn Casey Huang

2020-Current year OA Pubs

Filament formation by cytoskeletal proteins is critical to their involvement in myriad cellular processes. The bacterial actin homolog MreB, which is essential for cell-shape determination in many rod-shaped bacteria, has served as a model system for studying the mechanics of cytoskeletal filaments. Previous molecular dynamics (MD) simulations revealed that the twist of MreB double protofilaments is dependent on the bound nucleotide, as well as binding to the membrane or the accessory protein RodZ, and MreB mutations that modulate twist also affect MreB spatial organization and cell shape. Here, we show that MreB double protofilaments can adopt multiple twist states during …

A Prospective Cohort Study Of The Impact Of Outpatient Intensive Cardiac Rehabilitation On Depression And Cardiac Self-Efficacy, Kristin M Mckenzie, Lauren K Park, Eric J Lenze, Kristin Montgomery, Serene Rashdi, Elena Deych, Natalie A Stranczek, Erin J Mckenzie, Michael W Rich, Valene Garr Barry, Nidhi Talpade, Tessa Carson, Linda R Peterson, Susan B Racette, Lisa De Las Fuentes, Et Al.

2020-Current year OA Pubs

STUDY OBJECTIVE: To evaluate whether an Intensive Cardiac Rehabilitation (ICR) program improves depression and cardiac self-efficacy among patients with a qualifying cardiac diagnosis.

DESIGN: Prospective, longitudinal cohort design.

SETTING: Single-center, tertiary referral, outpatient cardiac rehabilitation center.

PARTICIPANTS: Patients with a qualifying diagnosis for ICR.

INTERVENTIONS: Outpatient ICR.

MAIN OUTCOME MEASURES: Mental health, as assessed using the Patient Health Questionnaire-9 (PHQ-9) and cardiac self-efficacy using the Cardiac Self-Efficacy (CSE) scale.

RESULTS: Of the 268 patients included (median age 69 y, 73% men), 70% had no depressive symptoms at baseline (PHQ-9 score <5). PHQ-9 scores improved in the overall sample (p < 0.0001), with greater improvements among patients with mild depressive symptoms at baseline (-4 points, p < 0.001) and those with moderate to severe depressive symptoms at baseline (-5.5 points, p < 0.001). Cardiac self-efficacy improved overall, and the two subsections of the cardiac self-efficacy questionnaire titled, "maintain function" and "control symptoms" improved (all p < 0.001).

CONCLUSIONS: Participation in an outpatient ICR program is associated with …

Genetic And Transcriptional Contributions To Relapse In Normal Karyotype Acute Myeloid Leukemia, Allegra A Petti, Saad M Khan, Ziheng Xu, Nichole Helton, Catrina C Fronick, Robert Fulton, Sai M Ramakrishnan, Sridhar Nonavinkere Srivatsan, Sharon E Heath, Peter Westervelt, Jacqueline E Payton, Matthew J Walter, Daniel C Link, John Dipersio, Christopher Miller, Timothy J Ley

2020-Current year OA Pubs

To better understand clonal and transcriptional adaptations after relapse in patients with acute myeloid leukemia (AML), we collected presentation and relapse samples from six normal karyotype AML cases. We performed enhanced whole-genome sequencing to characterize clonal evolution, and deep-coverage single-cell RNA sequencing on the same samples, which yielded 142,642 high-quality cells for analysis. Identifying expressed mutations in individual cells enabled us to discriminate between normal and AML cells, to identify coordinated changes in the genome and transcriptome, and to identify subclone-specific cell states. We quantified the coevolution of genetic and transcriptional heterogeneity during AML progression, and found that transcriptional changes …

Semaphorin-Plexin Signaling: From Axonal Guidance To A New X-Linked Intellectual Disability Syndrome, Jacqueline L Steele, Marwan S Shinawi, Et Al.

2020-Current year OA Pubs

BACKGROUND: Semaphorins and plexins are ligands and cell surface receptors that regulate multiple neurodevelopmental processes such as axonal growth and guidance. PLXNA3 is a plexin gene located on the X chromosome that encodes the most widely expressed plexin receptor in fetal brain, plexin-A3. Plexin-A3 knockout mice demonstrate its role in semaphorin signaling in vivo. The clinical manifestations of semaphorin/plexin neurodevelopmental disorders have been less widely explored. This study describes the neurological and neurodevelopmental phenotypes of boys with maternally inherited hemizygous PLXNA3 variants.

METHODS: Data-sharing through GeneDx and GeneMatcher allowed identification of individuals with autism or intellectual disabilities (autism/ID) and hemizygous …

Modulation Of Mirisc-Mediated Gene Silencing In Eukaryotes, Courtney F Jungers, Sergej Djuranovic

2020-Current year OA Pubs

Gene expression is regulated at multiple levels in eukaryotic cells. Regulation at the post-transcriptional level is modulated by various

Rare Coding Variants In Rcn3 Are Associated With Blood Pressure, Karen Y. He, D.C. Rao, Et Al.

2020-Current year OA Pubs

No abstract provided.

A Framework For Extension Studies Using Real-World Data To Examine Long-Term Safety And Effectiveness, Mehmet Burcu, Cyntia B Manzano-Salgado, Anne M Butler, Jennifer B Christian

2020-Current year OA Pubs

Understanding the long-term benefits and risks of treatments, devices, and vaccines is critically important for individual- and population-level healthcare decision-making. Extension studies, or 'roll-over studies,' are studies that allow for patients participating in a parent clinical trial to 'roll-over' into a subsequent related study to continue to observe and measure long-term safety, tolerability, and/or effectiveness. These designs are not new and are often used as an approach to satisfy regulatory post-approval safety requirements. However, designs using traditional clinical trial infrastructure can be expensive and burdensome to conduct, particularly, when following patients for many years post trial completion. Given the increasing …

Dermatologic Events Associated With The Anti-Ccr4 Antibody Mogamulizumab: Characterization And Management, Amy C M Musiek, Et Al.

2020-Current year OA Pubs

The CCR4-directed monoclonal antibody mogamulizumab has been shown to significantly improve progression-free survival and overall response rate compared with vorinostat in adults with relapsed/refractory mycosis fungoides (MF) and Sézary syndrome (SS). One of the most common adverse events seen with mogamulizumab in MF/SS patients is rash. Because of the protean nature of MF/SS and the variable clinical and histopathological features of mogamulizumab-associated rash, healthcare providers may have difficulty distinguishing rash from disease, and may not be aware of appropriate treatment strategies for this generally manageable adverse event. The objective of this report was to combine results from published literature with …

Il-1 Reprogramming Of Adult Neural Stem Cells Limits Neurocognitive Recovery After Viral Encephalitis By Maintaining A Proinflammatory State, Allison L Soung, Veronica A Davé, Charise Garber, Eric D Tycksen, Lauren L Vollmer, Robyn S Klein

2020-Current year OA Pubs

Innate immune responses to emerging RNA viruses are increasingly recognized as having significant contributions to neurologic sequelae, especially memory disorders. Using a recovery model of West Nile virus (WNV) encephalitis, we show that, while macrophages deliver the antiviral and anti-neurogenic cytokine IL-1β during acute infection; viral recovery is associated with continued astrocyte inflammasome-mediated production of inflammatory levels of IL-1β, which is maintained by hippocampal astrogenesis via IL-1R1 signaling in neural stem cells (NSC). Accordingly, aberrant astrogenesis is prevented in the absence of IL-1 signaling in NSC, indicating that only newly generated astrocytes exert neurotoxic effects, preventing synapse repair and promoting …

Library Newsletter : Issue 3 - 2022, Office Of The University Librarian

Office of the University Librarian Reports

CONTENT:

- Message by Peter Gatiti Associate Vice Provost & University Librarian

- Reading for Children

- Gilgit-Biltistan School Digital Library

- When Writing Hurts

- Library and CHS Collaborate with WHO on SHRH

- What to Read?

- EBSCO Discovery Service

- AKU Athor's Day

On-Road Vehicle Emission Measurements And Their Use In Evaluating Emission Control Effectiveness {Presentation}, Gary A. Bishop

Fuel Efficiency Automobile Test Publications

No abstract provided.

2021 West Los Angeles Data Summary, Gary Bishop

Fuel Efficiency Automobile Test Publications

Simple data summary for 2021 West Los Angeles on-road emission measurements.

Real Talk: A Realist Dialogic Approach In A Realist Evaluation, Emilie Francis-Auton, Mitchell N. Sarkies, Chiara Pomare, Janet C. Long, Rebecca Hardwick, Hoa Mi Nguyen, Jeffrey Braithwaite

Peninsula Medical School

Realist evaluation is a method increasingly adopted to provide an understanding of how and why a program works, for whom, and under what circumstances. Initial program theories (IPT) are the crucial starting point of any realist evaluation, however descriptions about how they are developed in practice remain under-reported in the published literature. This article argues for the value of genuine research-group conversations using David Bohm’s concept of dialogue in realist research. We label it the realist dialogic approach. We draw out the relational qualities as well as the contextual circumstances of dialogue through our development of IPT and interview guides …

Adapting And Validating The Autism Diagnostic Interview - Revised For Use With Deaf Children And Young People, Barry Wright, Helen Phillips, Victoria Allgar, Jennifer Sweetman, Rachel Hodkinson, Emily Hayward, Amelia Ralph-Lewis, Catarina Teige, Martin Bland, Couteur A Le

Peninsula Medical School

A Delphi consensus methodology was used to adapt the Autism Diagnostic Interview–Revised for the assessment of deaf children with suspected autism spectrum disorder. Each Autism Diagnostic Interview–Revised item was considered by a panel of nine international experts in terms of relevance and acceptability. Modifications were proposed and agreed by the expert panel for 45% of items. The pre-specified criterion for agreement between experts was set at 80% for each item. A first validation of the revised version, adapted for deaf children (Autism Diagnostic Interview–Revised Deaf Adaptation), was undertaken with a UK sample of 78 parents/carers of deaf children with autism …

Insights Into Nervous System Repair From The Fruit Fly, David Coupe, Torsten Bossing

Peninsula Medical School

Abstract Millions of people experience injury to the central nervous system (CNS) each year, many of whom are left permanently disabled, providing a challenging hurdle for the field of regenerative medicine. Repair of damage in the CNS occurs through a concerted effort of phagocytosis of debris, cell proliferation and differentiation to produce new neurons and glia, distal axon/dendrite degeneration, proximal axon/dendrite regeneration and axon re-enwrapment. In humans, regeneration is observed within the peripheral nervous system, while in the CNS injured axons exhibit limited ability to regenerate. This has also been described for the fruit fly Drosophila. Powerful genetic tools available …

Correction To: Epilepsy Related Multimorbidity, Polypharmacy And Risks In Adults With Intellectual Disabilities: A National Study, James J. Sun, Bhathika Perera, William Henley, Heather Angus-Leppan, Indermeet Sawhney, Lance Watkins, Kiran N. Purandare, Mogbeyiteren Eyeoyibo, Mark Scheepers, Geraldine Lines, Robert Winterhalder, Samantha Ashby, Silva R De, Jonjo Miller, David E. Philpott, Chris Ashwin, Joshua Howkins, Harriet Slater, David Medhurst, Rohit Shankar

Peninsula Medical School

Correction to: Journal of Neurology https://doi.org/10.1007/s00415-021-10938-3The original version of this article unfortunately contained a mistake. Author name Ravindu De Silva was incorrectly written as Ravi De Silva.

Differentially Private Fractional Frequency Moments Estimation With Polylogarithmic Space, Lun Wang, Iosif Pinelis, Dawn Song

Michigan Tech Publications, Part 1

We prove that Fp sketch, a well-celebrated streaming algorithm for frequency moments estimation, is differentially private as is when p ∈ (0, 1]. Fp sketch uses only polylogarithmic space, exponentially better than existing DP baselines and only worse than the optimal non-private baseline by a logarithmic factor. The evaluation shows that Fp sketch can achieve reasonable accuracy with differential privacy guarantee. The evaluation code is included in the supplementary material.

Covid Lockdowns In The Uk: Estimating Their Effects On Transmission, Emily Prestige, Julian Stander, Yinghui Wei

School of Engineering, Computing and Mathematics

No abstract provided.

On Sir David Cox's Publications, Mario Cortina Borja, Julian Stander, Giovanni Sebastiani

School of Engineering, Computing and Mathematics

No abstract provided.

Fea Modelling And Environmental Assessment Of A Thin-Walled Composite Drive Shaft, Joseph Searle, Maozhou Meng, John Summerscales

School of Engineering, Computing and Mathematics

Fibre reinforced plastics (FRP) composites have been widely used in the automotive industry with the primary focus on reduced mass. However, there are relatively few reports on their application on power transmission components, such as drive shafts. This paper explores the feasibility of replacing the traditional structural steel by light weight FRP composites in a drive shaft. Three FRP composites are considered against a steel drive shaft; basalt/epoxy, carbon/epoxy, and CNT (carbon nanotubes) reinforced carbon/epoxy composites. The mechanical performance was analysed by finite element analysis (FEA) tool and classical laminate theory (CLT), while the environmental performance was evaluated by life …

Developed Performance Of Rgo/P-Si Schottky Junction Solar Cells, Ahmed M. Suhail, Mazin Ahmed Abed, Samer Mahmmod Ahmed, Israa M.S. Al-Kadmy, Hiyam Altaii, Genhua Pan

School of Engineering, Computing and Mathematics

Graphene in combination with Si has been extensively used to prepare efficient and stable p-graphene/n-Si Schottky junction solar cells. In contrast, there is a difficulty in including graphene within the fabrication process of efficient and stable n-graphene/p-Si Schottky junction solar cells. The reason for this is that there is a challenge in achieving an effective and stable n-doping process for graphene or rGO due to the ambient environment. In this work, a novel approach is introduced for preparing more efficient, stable, larger and simpler n-rGO/p-Si Schottky junction solar cells. The n-rGO rather than graphene, which has been successfully developed using …

“Give Me A Path To Follow”: A Deweyan Inquiry Into Training Volunteer Eal Tutors Of Adult Refugees, Maria Enriquez Watt

Theses: Doctorates and Masters

Volunteer English as an additional language (EAL) tutors working through adult community education (ACE) organisations play a key role in the development of adult refugee literacy and language skills in Australia. There are few requirements to work as an EAL volunteer tutor (VT), other than fluency in English. Yet refugee learners are known to have complex learning problems potentially resulting from their pre-migratory experiences. However, as the ACE sector is unregulated, provision for training VTs is uncoordinated, with many VTs receiving little or no training. Available training has largely been found to be ineffective and to support ideologies that potentially …