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Articles 164911 - 164940 of 167936
Full-Text Articles in Entire DC Network
Data Driven Bayesian Network To Predict Critical Alarm, Joseph Mietkiewicz, Anders Madsen
Data Driven Bayesian Network To Predict Critical Alarm, Joseph Mietkiewicz, Anders Madsen
Articles
Modern industrial plants rely on alarm systems to ensure their safe and effective functioning. Alarms give the operator knowledge about the current state of the industrial plants. Trip alarms indicating a trip event indicate the shutdown of systems. Trip events in power plants can be costly and critical for the running of the operation.This paper demonstrates how trips events based on an alarm log from an offshore gas production can be reliably predicted using a Bayesian network. If a trip event is reliably predicted and the main cause of it is identified, it will allow the operator to prevent it. …
Improvement Of The Fine Tuning Algorithm, Joseph Mietkiewicz, Anders Madsen
Improvement Of The Fine Tuning Algorithm, Joseph Mietkiewicz, Anders Madsen
Articles
Khalil El Hindi has developed a fine-tuning algorithm to
improve the classification accuracy of the Naive Bayes. His algorithm optimizes the conditional probability tables of the Naive Bayes after the
training phase. The values of the probabilities of a variable are modified if it causes misclassification of a training instance. The algorithm out-performs in many cases the Naive Bayes. We analyze the performance
of the algorithm, discussed its issues, and compare it to a modified algorithm. The new algorithm simplifies the formula used in the fine-tuning algorithm and uses a more efficient scoring metric, the Brier score, to
fine-tune the …
Development Of Modular And Adaptive Laboratory Set-Up For Neuroergonomic And Human-Robot Interaction Research, Marija Savkovic, Carlo Caiazzo, Marko Djapan, Arso M. Vukic´ Evi, Milos Pusica, Ivan Macˇ Užic
Development Of Modular And Adaptive Laboratory Set-Up For Neuroergonomic And Human-Robot Interaction Research, Marija Savkovic, Carlo Caiazzo, Marko Djapan, Arso M. Vukic´ Evi, Milos Pusica, Ivan Macˇ Užic
Articles
The industry increasingly insists on academic cooperation to solve the identified problems such as workers' performance, wellbeing, job satisfaction, and injuries. It causes an unsafe and unpleasant working environment that directly impacts the quality of the product, workers' productivity, and effectiveness. This study aimed to give a specialized solution for tests and explore possible solutions to the given problem in neuroergonomics and human-robot interaction. The designed modular and adaptive laboratory model of the industrial assembly workstation represents the laboratory infrastructure for conducting advanced research in the field of ergonomics, neuroergonomics, and human-robot interaction. It meets the operator's anatomical, anthropometric, physiological, …
Organizational Perspectives On Outdoor Talking Therapy: Towards A Position Of ‘Environmental Safe Uncertainty’, Sam J. Cooley, Ceri R. Jones, Duncan Moss, Noelle Robertson
Organizational Perspectives On Outdoor Talking Therapy: Towards A Position Of ‘Environmental Safe Uncertainty’, Sam J. Cooley, Ceri R. Jones, Duncan Moss, Noelle Robertson
School of Psychology
No abstract provided.
Heterogeneous Weathering Of Polypropylene In The Marine Environment, John W. Scott, Andrew Turner, Andres F. Prada, Linduo Zhao
Heterogeneous Weathering Of Polypropylene In The Marine Environment, John W. Scott, Andrew Turner, Andres F. Prada, Linduo Zhao
School of Geography, Earth and Environmental Sciences
No abstract provided.
Bioaccumulation, Release And Genotoxicity Of Stainless Steel Particles In Marine Bivalve Molluscs, Emily L. Vernon, Awadhesh N. Jha, Maria F. Ferreira, Danielle L. Slomberg, Veronique Malard, Christian Grisolia, Mickaël Payet, Andrew Turner
Bioaccumulation, Release And Genotoxicity Of Stainless Steel Particles In Marine Bivalve Molluscs, Emily L. Vernon, Awadhesh N. Jha, Maria F. Ferreira, Danielle L. Slomberg, Veronique Malard, Christian Grisolia, Mickaël Payet, Andrew Turner
School of Biological and Marine Sciences
No abstract provided.
Experimental Evaluation Of Plastic Wake On Growing Fatigue Cracks From The Analysis Of Residual Displacement Fields, Jm Vasco‐Olmo, Francisco A. Díaz, A Camacho‐Reyes, Neil James, Fernando V. Antunes
Experimental Evaluation Of Plastic Wake On Growing Fatigue Cracks From The Analysis Of Residual Displacement Fields, Jm Vasco‐Olmo, Francisco A. Díaz, A Camacho‐Reyes, Neil James, Fernando V. Antunes
School of Engineering, Computing and Mathematics
A growing fatigue crack gives rise to a plastically deformed wake of material that envelops the crack. In this work, the plastic wake extent during fatigue crack growth is experimentally quantified by analyzing the crack tip displacement fields measured with digital image correlation. A novel technique based on use of a yield criterion is proposed that uses the undamaged state of the specimen as the reference state in the image processing. The plastic wake was identified by differentiation of the residual displacement fields obtained with a near-zero load level to avoid any rigid body motion. The plastic wake extent was …
Validity Of Small-Scale Yielding Regime In Notched-Cracked Geometries, Mf Borges, Fv Antunes, Dm Neto, Jm Vasco-Olmo, Fa Díaz, Mn James
Validity Of Small-Scale Yielding Regime In Notched-Cracked Geometries, Mf Borges, Fv Antunes, Dm Neto, Jm Vasco-Olmo, Fa Díaz, Mn James
School of Engineering, Computing and Mathematics
No abstract provided.
Assessment Of Equivalent Substrate Stiffness And Mechanical Properties Of Sustainable Alkali-Activated Concrete Containing Recycled Concrete Aggregate, Nattapong Damrongwiriyanupap, Todsaporn Srikhamma, Chittinat Plongkrathok, Tanakorn Phoo-Ngernkham, Worathep Sae-Long, Sakonwan Hanjitsuwan, Piti Sukontasukkul, Long Yuan Li, Prinya Chindaprasirt
Assessment Of Equivalent Substrate Stiffness And Mechanical Properties Of Sustainable Alkali-Activated Concrete Containing Recycled Concrete Aggregate, Nattapong Damrongwiriyanupap, Todsaporn Srikhamma, Chittinat Plongkrathok, Tanakorn Phoo-Ngernkham, Worathep Sae-Long, Sakonwan Hanjitsuwan, Piti Sukontasukkul, Long Yuan Li, Prinya Chindaprasirt
School of Engineering, Computing and Mathematics
The effects of using recycled concrete aggregate (RCA) as coarse aggregate on the equivalent substrate stiffness and mechanical properties of sustainable alkali-activated concrete were investigated in this paper. High-calcium fly ash (HFA) and commercial silica fume (SF) were used as the precursors for producing the alkali-activated high-calcium fly ash concrete (AAHFAC). Sodium hydroxide (SH) and sodium silicate (SS) solutions were used as alkaline activator solutions with the constant SS/SH ratio of 1.0 and liquid-binder (L/B) ratio of 0.50. The natural coarse aggregate (NCA) used in this study was crushed limestone and replaced with RCA at the rates of 0%, 20%, …
Towards A New Methodology For The Characterisation Of Crack Tip Fields Based On A Hybrid Computational Approach, A Camacho-Reyes, Jm Vasco-Olmo, Mn James, Fa Diaz
Towards A New Methodology For The Characterisation Of Crack Tip Fields Based On A Hybrid Computational Approach, A Camacho-Reyes, Jm Vasco-Olmo, Mn James, Fa Diaz
School of Engineering, Computing and Mathematics
No abstract provided.
Analysis Of Electrical Conductivity Of Carbon Nanotube-Reinforced Two-Phase Composites, Z Li, L-Y Li
Analysis Of Electrical Conductivity Of Carbon Nanotube-Reinforced Two-Phase Composites, Z Li, L-Y Li
School of Engineering, Computing and Mathematics
No abstract provided.
Surface Quality Augmentation For Metalworking Industry With Pix2pix, Dirk Hölscher, Christoph Reich, Martin Knahl, Frank Gut, Nathan Clarke
Surface Quality Augmentation For Metalworking Industry With Pix2pix, Dirk Hölscher, Christoph Reich, Martin Knahl, Frank Gut, Nathan Clarke
School of Engineering, Computing and Mathematics
No abstract provided.
Simulation Of Heritage Buildings: The Duke Of Bedford's Cottages In West Devon, Jack Morewood, Pieter De Wilde
Simulation Of Heritage Buildings: The Duke Of Bedford's Cottages In West Devon, Jack Morewood, Pieter De Wilde
School of Art, Design and Architecture
Building performance simulation (BPS) is used to select and justify an energy-saving retrofit for the Duke of Bedford's cottages, aiming to improve performance sufficiently within the cottages' constraints, which include conservation concerns plus wider practical and economic constraints. Building data is passed from a building information model (BIM). Building energy simulation (BES) and hygrothermal modelling obtain results in the performance attributes of energy efficiency, thermal comfort and damp risk. Parametric analysis assesses performance ranges and sensitivity to long-term climate uncertainties. Moderate fabric upgrades, including window replacement and an insulating plaster, perform best within their constraints. Long-term, a heat pump is …
Characterization Of Non‐Planar Crack Tip Displacement Fields Using A Differential Geometry Approach In Combination With 3d Digital Image Correlation, A Camacho‐Reyes, Jm Vasco‐Olmo, Mn James, Fa Diaz
Characterization Of Non‐Planar Crack Tip Displacement Fields Using A Differential Geometry Approach In Combination With 3d Digital Image Correlation, A Camacho‐Reyes, Jm Vasco‐Olmo, Mn James, Fa Diaz
School of Engineering, Computing and Mathematics
No abstract provided.
At‐Risk Alcohol Users Have Disrupted Valence Discrimination During Reward Anticipation, Mica Komarnyckyj, Chris Retzler, Zhipeng Cao, Giorgio Ganis, Anna Murphy, Robert Whelan, Elsa Florence Fouragnan
At‐Risk Alcohol Users Have Disrupted Valence Discrimination During Reward Anticipation, Mica Komarnyckyj, Chris Retzler, Zhipeng Cao, Giorgio Ganis, Anna Murphy, Robert Whelan, Elsa Florence Fouragnan
School of Psychology
No abstract provided.
Spirituality And Prayer: Biblical Foundations And Models For Current Dilemmas, Hebert Davi Liessi, Lucicleide Maria Da Silva Liessi
Spirituality And Prayer: Biblical Foundations And Models For Current Dilemmas, Hebert Davi Liessi, Lucicleide Maria Da Silva Liessi
All Books
Every human being seeks to be happy. However, it faces several challenges in this process. These challenges are considered as deserts that each person goes through on the journey of life. Spirituality and prayer are practices that go together and are used by many religions to help human beings live with more satisfaction and find themselves and God. This book brings biblical reflections to deepen the journey of intimacy with God. In addition, it seeks to systematize the pillars of prayer from the perspective of biblical spirituality and apply them to improving personal and spiritual life.
Biblical Anthropology: Foundations And Teaching Models, Hebert Davi Liessi, Lucicleide Maria Da Silva Liessi
Biblical Anthropology: Foundations And Teaching Models, Hebert Davi Liessi, Lucicleide Maria Da Silva Liessi
All Books
Human beings have searched for meaning in different ways over the millennia. This book presents how God sees the human being from a biblical-grammatical perspective through the book of Exodus. The sense of existence has new sources, with God and his purpose for each individual and humanity being the main ones. In addition, this book analyses and offers possibilities and models for teaching biblical anthropology to university students.
Regulatory Flexibilities And Access To Covid-19 Vaccines During The Pandemic In Bhutan, Dawa Tshering, Pelden Chejor
Regulatory Flexibilities And Access To Covid-19 Vaccines During The Pandemic In Bhutan, Dawa Tshering, Pelden Chejor
Research outputs 2022 to 2026
Summary Coronavirus disease 2019 (COVID-19) is rapidly evolving with millions of cases and death reported globally. The first-ever case of COVID-19 in Bhutan was confirmed on 5 March 2020 in a 76-year-old American tourist. The national regulatory authorities have implemented varying degrees of regulatory flexibilities to prevent unnecessary death by ensuring timely access to medical products and technologies during the pandemic. The Drug Regulatory Authority of Bhutan, as a national medicines regulatory agency responsible for ensuring the quality of medical products has implemented several regulatory mechanisms to ensure access to medical products including COVID-19 vaccines during the pandemic. In this …
Integrating Indigenous Perspectives In The Drama Class: Pre-Service Teachers' Perceptions And Attitudes, Elisa M. Williams, Julia Morris
Integrating Indigenous Perspectives In The Drama Class: Pre-Service Teachers' Perceptions And Attitudes, Elisa M. Williams, Julia Morris
Research outputs 2022 to 2026
Currently, educational bodies are recognising the importance of integrating Australian Indigenous cultures in education to promote intercultural understanding and improve outcomes for Indigenous students. In drama, learning about Indigenous perspectives can be integrated through sharing cultural stories, with this integration mandated by the Australian curriculum. However, teachers are struggling to achieve this directive due to a lack of knowledge in Indigenous content and concerns surrounding permission and cultural appropriation. This qualitative study used a focus group interview to determine non-Indigenous pre-service drama teachers' perceptions about integrating Indigenous perspectives in their praxis. Inductive analysis of the data revealed participants strongly believed …
Mathematical Connections Established In The Teaching Of Functions, Vesife Hatisaru
Mathematical Connections Established In The Teaching Of Functions, Vesife Hatisaru
Research outputs 2022 to 2026
This study explores the types of mathematical connections established in the classroom in the teaching of functions. An extended model for mathematical connections (different representations (DR), procedural (PC), if-then (I-T), part-whole connections (PWC), feature/property (F/P), analogies, and instruction-oriented connections (IOC)) is used as the analytical framework. The context for the study is classroom observations of two secondary mathematics teachers teaching functions to Grade 9 students. The strength of teachers’ mathematical knowledge for teaching (MKT) the concept of function is different: one has stronger MKT, while the other has weaker MKT. A total of 485 connections are identified in a sample …
Ancestral Sars-Cov-2, But Not Omicron, Replicates Less Efficiently In Primary Pediatric Nasal Epithelial Cells, Yanshan Zhu, Keng Yih Chew, Melanie Wu, Anjana C. Karawita, Georgina Mccallum, Lauren E. Steele, Ayaho Yamamoto, Larisa I. Labzin, Tejasri Yarlagadda, Alexander A. Khromykh, Xiaohui Wang, Julian D. J. Sng, Claudia J. Stocks, Yao Xia, Tobias R. Kollmann, David Martino, Merja Joensuu, Frédéric A. Meunier, Giuseppe Balistreri, Helle Bielefeldt-Ohmann, Asha C. Bowen, Anthony Kicic, Peter D. Sly, Kirsten M. Spann, Kirsty R. Short
Ancestral Sars-Cov-2, But Not Omicron, Replicates Less Efficiently In Primary Pediatric Nasal Epithelial Cells, Yanshan Zhu, Keng Yih Chew, Melanie Wu, Anjana C. Karawita, Georgina Mccallum, Lauren E. Steele, Ayaho Yamamoto, Larisa I. Labzin, Tejasri Yarlagadda, Alexander A. Khromykh, Xiaohui Wang, Julian D. J. Sng, Claudia J. Stocks, Yao Xia, Tobias R. Kollmann, David Martino, Merja Joensuu, Frédéric A. Meunier, Giuseppe Balistreri, Helle Bielefeldt-Ohmann, Asha C. Bowen, Anthony Kicic, Peter D. Sly, Kirsten M. Spann, Kirsty R. Short
Research outputs 2022 to 2026
Children typically experience more mild symptoms of Coronavirus Disease 2019 (COVID-19) when compared to adults. There is a strong body of evidence that children are also less susceptible to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection with the ancestral viral isolate. However, the emergence of SARS-CoV-2 variants of concern (VOCs) has been associated with an increased number of pediatric infections. Whether this is the result of widespread adult vaccination or fundamental changes in the biology of SARS-CoV-2 remain to be determined. Here, we use primary nasal epithelial cells (NECs) from children and adults, differentiated at an air-liquid interface to …
Assessment And Monitoring Of Achilles Tendinopathy In Clinical Practice: A Qualitative Descriptive Exploration Of The Barriers Clinicians Face, Myles Calder Murphy, James Debenham, Caroline Bulsara, Paola Chivers, Ebonie Kendra Rio, Sean Docking, Mervyn Travers, William Gibson
Assessment And Monitoring Of Achilles Tendinopathy In Clinical Practice: A Qualitative Descriptive Exploration Of The Barriers Clinicians Face, Myles Calder Murphy, James Debenham, Caroline Bulsara, Paola Chivers, Ebonie Kendra Rio, Sean Docking, Mervyn Travers, William Gibson
Research outputs 2022 to 2026
Our primary objective was to explore the barriers preventing clinicians from implementing what they think is ideal practice as it relates to using tools to aid diagnosis and monitor progress in mid-portion Achilles tendinopathy. Our secondary objectives were to describe the assessments employed by clinicians in their own practice to aid with (a) diagnosis and (b) monitoring progress in Achilles tendinopathy and explore the outcome measure domains clinicians believe to be the most and least important when managing patients with Achilles tendinopathy. We employed a qualitative descriptive study design. Thirteen participants (eight female, five male) from across Australia, consisting of …
Bioturbation By Echidna (Tachyglossus Aculeatus) In A Forest Habitat, South-Western Australia, Shannon J. Dundas, Lara Osborne, Anna J. M. Hopkins, Katinka X. Ruthrof, Patricia A. Fleming
Bioturbation By Echidna (Tachyglossus Aculeatus) In A Forest Habitat, South-Western Australia, Shannon J. Dundas, Lara Osborne, Anna J. M. Hopkins, Katinka X. Ruthrof, Patricia A. Fleming
Research outputs 2022 to 2026
Bioturbation by digging animals is important for key forest ecosystem processes such as soil turnover, decomposition, nutrient cycling, water infiltration, seedling recruitment, and fungal dispersal. Despite their widespread geographic range, little is known about the role of the short-beaked echidna (Tachyglossus aculeatus) in forest ecosystems. We measured the density and size of echidna diggings in the Northern Jarrah Forest, south-western Australia, to quantify the contribution echidna make to soil turnover. We recorded an overall density of 298 echidna diggings per hectare, 21 % of which were estimated to be less than 1 month old. The average size of digs was …
Cohort Profile: The Growing Up Healthy Study (Guhs)—A Prospective And Observational Cohort Study Investigating The Long-Term Health Outcomes Of Offspring Conceived After Assisted Reproductive Technologies, Roger J. Hart, Blagica Penova-Veselinovic, Laura A. Wijs, John L. Yovich, Peter Burton
Cohort Profile: The Growing Up Healthy Study (Guhs)—A Prospective And Observational Cohort Study Investigating The Long-Term Health Outcomes Of Offspring Conceived After Assisted Reproductive Technologies, Roger J. Hart, Blagica Penova-Veselinovic, Laura A. Wijs, John L. Yovich, Peter Burton
Research outputs 2022 to 2026
Worldwide, over 8 million children and adults are conceived following assisted reproductive technologies (ART), and their long-term health is of consequential public health interest. The objective of this paper is to describe the Growing up Healthy Study (GUHS) cohort in detail, publicise it and invite collaboration. Combining the data collected in the GUHS with other cohorts or databases will improve the much-needed knowledge about the effects of ART, and allow for better understanding of the long-term health outcomes of offspring conceived after ART. The GUHS cohort is a prospective observational study of adolescents and young adults conceived after assisted reproductive …
Comparison Of Auditory Steady-State Responses With Conventional Audiometry In Older Adults, Hadeel Y. Tarawneh, Hamid R. Sohrabi, Wilhelmina H. A. M. Mulders, Ralph N. Martins, Dona M. P. Jayakody
Comparison Of Auditory Steady-State Responses With Conventional Audiometry In Older Adults, Hadeel Y. Tarawneh, Hamid R. Sohrabi, Wilhelmina H. A. M. Mulders, Ralph N. Martins, Dona M. P. Jayakody
Research outputs 2022 to 2026
Behavioral measures, such as pure-tone audiometry (PTA), are commonly used to determine hearing thresholds, however, PTA does not always provide reliable hearing information in difficult to test individuals. Therefore, objective measures of hearing sensitivity that require little-to-no active participation from an individual are needed to facilitate the detection and treatment of hearing loss in difficult to test people. Investigation of the reliability of the auditory steady-state response (ASSR) for measuring hearing thresholds in older adults is limited. This study aimed to investigate if ASSR can be a reliable, objective measure of frequency specific hearing thresholds in older adults. Hearing thresholds …
Evidence For Global Health Care Interventions For Preterm Or Low Birth Weight Infants: An Overview Of Systematic Reviews, Karen Edmond, Natalie Strobel
Evidence For Global Health Care Interventions For Preterm Or Low Birth Weight Infants: An Overview Of Systematic Reviews, Karen Edmond, Natalie Strobel
Research outputs 2022 to 2026
Contex: Twenty-four research questions (framed as population, intervention, comparator, and outcomes) for global health care interventions for preterm and low birth weight (LBW) infants were identified at a World Health Organization guideline development group expert meeting in December 2020. Objective: To describe which systematic reviews had addressed these research questions in the last 3 years. Data sources: Medline (Ovid); the Cochrane Database of Systematic Reviews; the Cochrane Database of Systematic Review Protocols; and the PROSPERO International prospective register of systematic reviews databases from January 1, 2019 to December 31, 2021 were used.Randomized controlled trials or observational studies. Two reviewers independently …
Effects Of Cannabis On Congenital Limb Anomalies In 14 European Nations: A Geospatiotemporal And Causal Inferential Study, Albert Stuart Reece, Gary Kenneth Hulse
Effects Of Cannabis On Congenital Limb Anomalies In 14 European Nations: A Geospatiotemporal And Causal Inferential Study, Albert Stuart Reece, Gary Kenneth Hulse
Research outputs 2022 to 2026
Cannabinoid exposure is increasing in some European nations. Europe therefore provides an interesting test environment for the recently reported link between cannabis exposure and congenital limb anomaly (CLA) rates (CLARs). Exponential genotoxic dose–response relationships make this investigation both intriguing and imperative. Annual CLAR in 14 nations were from Epidemiological Surveillance of Congenital Anomalies. Drug use rates were from European Monitoring Centre for Drugs and Drug Dependency. Median household income was from the World Bank. E-values provide a quantitative measure of robustness of results to confounding by extraneous covariates. Inverse probability weighting is an important technique for equalizing exposures across countries …
Identification Of Leukocyte Surface P2x7 As A Biomarker Associated With Alzheimer's Disease, Yihan Li, Xin Huang, Christopher Fowler, Yen Y. Lim, Simon M. Laws, Noel Faux, James D. Doecke, Brett Trounson, Kelly Pertile, Rebecca Rumble, Vincent Doré, Victor L. Villemagne, Christopher C. Rowe, James S. Wiley, Paul Maruff, Colin L. Masters, Ben J. Gu
Identification Of Leukocyte Surface P2x7 As A Biomarker Associated With Alzheimer's Disease, Yihan Li, Xin Huang, Christopher Fowler, Yen Y. Lim, Simon M. Laws, Noel Faux, James D. Doecke, Brett Trounson, Kelly Pertile, Rebecca Rumble, Vincent Doré, Victor L. Villemagne, Christopher C. Rowe, James S. Wiley, Paul Maruff, Colin L. Masters, Ben J. Gu
Research outputs 2022 to 2026
Alzheimer's disease (AD) has shown altered immune responses in the periphery. We studied P2X7 (a proinflammatory receptor and a scavenger receptor) and two integrins, CD11b and CD11c, on the surface of circulating leukocytes and analysed their associations with Aβ-PET, brain atrophy, neuropsychological assessments, and cerebrospinal fluid (CSF) biomarkers. Total 287 age-matched, sex-balanced participants were recruited in a discovery cohort and two validation cohorts through the AIBL study and studied using tri-colour flow cytometry. Our results demonstrated reduced expressions of P2X7, CD11b, and CD11c on leukocytes, particularly monocytes, in Aβ +ve cases compared with Aβ -ve controls. P2X7 and integrin downregulation …
Lacking Clarity Or Strategic Ambiguity? Comment On “Competing Frames In Global Health Governance: An Analysis Of Stakeholder Influence On The Political Declaration On Non-Communicable Diseases”, Angela Carriedo, Kathrin Lauber, Margaret M. Miller, Rob Ralston
Lacking Clarity Or Strategic Ambiguity? Comment On “Competing Frames In Global Health Governance: An Analysis Of Stakeholder Influence On The Political Declaration On Non-Communicable Diseases”, Angela Carriedo, Kathrin Lauber, Margaret M. Miller, Rob Ralston
Research outputs 2022 to 2026
This commentary engages with Suzuki and colleagues’ analysis about the ambiguity of multi-stakeholder discourses in the United Nations (UN) Political Declaration of the 3rd High-Level Meeting of the General Assembly on the Prevention and Control of Non-Communicable Diseases (HLM-NCDs), suggesting that blurring between public and private sector in this declaration reflects broader debates about multi-stakeholder partnerships (MSPs) and public-private partnerships (PPPs) in health governance. We argue that the ambiguity between the roles and responsibilities of public and private actors involved may downplay the role (and regulation) of conflicts of interest (COI) between unhealthy commodity industries and public health. We argue …
Limbal Bcam Expression Identifies A Proliferative Progenitor Population Capable Of Holoclone Formation And Corneal Differentiation, Yuzuru Sasamoto, Catherine A. A. Lee, Brian J. Wilson, Florian Buerger, Gabrielle Martin, Ananda Mishra, Shoko Kiritoshi, Johnathan Tran, Gabriel Gonzalez, Friedhelm Hildebrandt, Vickie Y. Jo, Christine G. Lian, George F. Murphy, Bruce R. Ksander, Markus H. Frank, Natasha Y. Frank
Limbal Bcam Expression Identifies A Proliferative Progenitor Population Capable Of Holoclone Formation And Corneal Differentiation, Yuzuru Sasamoto, Catherine A. A. Lee, Brian J. Wilson, Florian Buerger, Gabrielle Martin, Ananda Mishra, Shoko Kiritoshi, Johnathan Tran, Gabriel Gonzalez, Friedhelm Hildebrandt, Vickie Y. Jo, Christine G. Lian, George F. Murphy, Bruce R. Ksander, Markus H. Frank, Natasha Y. Frank
Research outputs 2022 to 2026
The corneal epithelium is renowned for high regenerative potential, which is dependent on the coordinated function of its diverse progenitor subpopulations. However, the molecular pathways governing corneal epithelial progenitor differentiation are incompletely understood. Here, we identify a highly proliferative limbal epithelial progenitor subpopulation characterized by expression of basal cell adhesion molecule (BCAM) that is capable of holocone formation and corneal epithelial sheet generation. BCAM-positive cells can be found among ABCB5-positive limbal stem cells (LSCs) as well as among ABCB5-negative limbal epithelial cell populations. Mechanistically, we show that BCAM is functionally required for cellular migration and differentiation and that its expression …