Digital Commons Network^™

Promoting Vaccine Innovation, Mirit Eyal-Cohen, Ana Santos Rutschman

Faculty Publications

As society grows to understand the need to promote innovation, policymakers try to employ an arsenal of policy tools, from traditional intellectual property (“IP”) to newer tools such as grants, regulatory vouchers, and prizes. This Article argues that these frameworks crowd out certain types of investments in innovation projects that have a high social value. Vaccine innovation is a case in point. Despite the immense socioeconomic benefit of vaccines, existing policies have been limited in fostering investments in this space. This is because they fail to directly address the relevant bottleneck issues distinct to vaccine development.

This Article offers a …

Investigating Seed Maturation And Mortality: A Mechanism For Post-Fire Regeneration In Non-Serotinous Conifers, Madeleine A. Lopez

Cal Poly Humboldt theses and projects

Climate warming and associated dry conditions are contributing to increased fire frequency, severity, and size, for many regions in western North America. These changes in fire activity have prompted concern over the long-term persistence of some conifer species, specifically those not adapted to withstand high-severity fire. However, regeneration of non-serotinous conifer species is possible if the timing of fire occurs following seed maturation, and within a heat range that seeds can withstand, in a regenerative mechanism termed “facultative serotiny.” To address this mechanism, I determined the timing of conifer seed maturation using viability testing for four California conifer species: ponderosa …

Variation Of Larval Traits And Copper Tolerance In An Invasive Cryptic Species Complex (Watersipora: Bryozoa), Jason A. Lopiccolo

Cal Poly Humboldt theses and projects

Many factors contribute to the potential of a non-indigenous species to invade an area and become established. For bryozoan colonies of the cryptic species complex Watersipora (Neviani, 1896), this may include larval characteristics such as settlement rate, competency of metamorphosis, swimming duration, and the ability to tolerate copper, a common component in marine anti-fouling paints. Two common groups of Watersipora that occur along the California coast are W. subatra Clade A and an undescribed new species, Clade N. The goal of this research work was to discover what differences, if any, exist in the larval traits and copper tolerances of …

A Theater Of The Absurd: Economic Sanctions In The Emerging Age Of Multipolarity, Travis Cunha

Cal Poly Humboldt theses and projects

Economic Sanctions have been imposed on nations throughout the Global South during the post-World War Two era. This led to the “Sanctions Decade” of the 1990s which saw the most devastating impacts on civilians in nations like Haiti and Iraq. The 2014 Russian annexation of Crimea resulted in sanctions being imposed on Russia by the European Union (EU), and retaliatory counter-sanctions from Moscow ensued shortly after. The Russian counter-sanctions banned the importation of certain agricultural foodstuffs from the EU, and this ban had significant implications for farmers in the EU who were now unable to sell to the large Russian …

Evaluation Of A Veterans Treatment Court In The Northwest United States, Jacob Davis Stalcup

Cal Poly Humboldt theses and projects

This thesis provides an evaluation of a Veterans Treatment Court in the northwestern United States. Previously collected data from clients within the court was analyzed and helped format semi-structured interviews with court employees. The conclusion of this evaluation is that the court would operate more effectively if there was a focus on the recruitment and retention of veteran employees, especially peer mentors. This could be accomplished by policy changes involving hiring new employees.

Narratives Of Positionality In Primatology: Foreign/Range–Country Collaborator Perspectives From Africa And South America, Michelle A. Rodrigues, Vicent Kiiza, Matthew R. Mclennan, Sérgio L. Mendes, Karen B. Strier

Social and Cultural Sciences Faculty Research and Publications

Primate research and conservation may inadvertently reproduce neocolonial dynamics when primatologists from affluent, imperialist nations conduct studies in primate habitat countries. Here, we consider how interrogating the positionality of both foreign researchers and range-country collaborators can strengthen primatology. Such consideration may help us to better understand where each member of the collaboration is coming from, both figuratively and literally, and how those situated perceptions shape the research process. Centering the perspectives of the range-country collaborators, whose perspectives are infrequently voiced within the primatology literature, may illuminate challenges in cross-cultural communication and imbalances of knowledge and power. Here, we explore how …

Our Place In Research: Understanding Social Productions Of Knowledge Using Digital Spaces, Allison C. Iafrate

Cal Poly Humboldt theses and projects

Academic research and research-writing are increasingly being recognized across disciplines as social and collaborative processes, involving many different voices and perspectives in the negotiation of meaning. However, within the context of the university classroom, research is often framed as an individualized process where students learn and perform research skills as single authors. This project approaches this discrepancy with a critical eye towards change by introducing digital spaces as a tool for reframing student perceptions of academic research. A selected review of literature is offered, which touches on topics such as critical research pedagogy, language varieties and language-play, multimodality and genres …

Settler Colonialism And White Environmentalism In The 'Uba, Aleena Church

Cal Poly Humboldt theses and projects

Settler colonialism continues to shape present injustices of Indigenous Peoples. The settlers of Nevada County do not recognize the historical past of colonialism and how it has changed the Nisenan Tribes relationship to these lands/waters. Or how colonization still thrives in Nevada County through settler relationships with these lands/waters. Settler colonialism is ongoing, it is not an event that happened during the gold rush. I use the South 'Uba River (South Yuba River) as an example for how settler colonialism continues to perpetuate violence and genocide amongst the Nisenan Peoples. As we, settlers, occupy these lands and waters we must …

Geomorphic Evaluation Of The Goose Lake Fault And Fluvial Terraces At The Yager Creek–Van Duzen River Confluence, Northern Coastal California, Samuel E. Bold

Cal Poly Humboldt theses and projects

Upper-plate deformation in the southern Cascadia subduction zone is dynamic and complex, situated in the transition between northward translation to westward convergence. Rock uplift and incision rates characteristic of this dynamic region are preserved in suites of fluvial and marine terraces. Fluvial terraces at the Yager Creek–Van Duzen River confluence record fluvial incision rates, and are crosscut by the understudied Goose Lake fault, an upper plate structure. In this work, I use high resolution lidar imagery to map terrace surfaces, and use optically stimulated luminescence, radiocarbon, and Beryllium-10 geochronology to bracket terrace ages and calculate incision and slip rates. With …

A Characterization Of The Sandy Beach Surf Zone Fish Community And Their Ecology In Northern California And The Effects Of Marine Protected Areas, Katie B. Terhaar

Cal Poly Humboldt theses and projects

Historically written off as dull and homogenous, the dynamics of the sandy beach surf zone remains under studied world-wide. Northern California has been no exception to this global standard, as the sandy beach surf zone ecosystem in this region has yet to be characterized, and the effect of Marine Protected Areas (MPAs) on the fish and macroinvertebrate community fully ascertained.

Considered data-poor by local wildlife officials, commercially, recreationally and culturally important Amphistichus rhodoterus (redtail surfperch) and common Hyperprosopon ellipticum (silver surfperch) utilize the sandy beach surf zone in Northern California. Little is known about the effect of various environmental factors, …

Teaching Conversation Skills Using Bst And Video Modeling Via Telehealth, Margaret F. Groves-Bradley

Cal Poly Humboldt theses and projects

Abstract

The COVID-19 pandemic and the current state of education children have limited access to an environment where they can practice conversational skills with people outside of their immediate family. Traditionally, children with autism spectrum disorder (ASD) have a difficult time independently learning these skills, even in an environment that is ripe with social interaction(Grosberg & Charlop, 2017). The current study sought to use behavioral skills training, modeling, and prompting to teach the skills of responding to questions, asking questions, and changing the topic to one learner with ASD over telehealth. The study was conducted over three phases. The first …

Foraging Behavior Of Honeybees Exposed To Mosquito Insecticides, Samantha Marie Diel

Cal Poly Humboldt theses and projects

The main aim of this study was to quantify the effects of mosquito insecticides on honey bee (Apis mellifera), foraging behavior, explicitly assessing the impacts of adult mosquito control practices on honey bee health. The extent to which honey bees are exposed to pyrethrum, pyrethrins, permethrin, and pyrethroids is unknown, as are their effects on honey bee health and vitality. This study sought to answer this question by exposing honey bees to D-Phenothrin with the addition of Piperonyl butoxide (PBO), one of many synthetic pyrethroids widely used against adult mosquitoes to control mosquito-borne diseases. Honey bees were exposed to …

Behavioral Differences In Urban Sciurus Carolinensis With Varying Human Exposure As A Model For Synanthropic Human-Animal Relationships, Tiffany M. Jordan

EWU Masters Thesis Collection

Synanthropic animals are considered a halfway point between wild and domestic animals that live in urban environments and depend on humans for their survival. Sciurus carolinensis, the eastern gray squirrel, symbolizes a distinctive coexistence between human and wildlife as they are commonly fed in parks and gardens. They are native to the eastern United States. Where they are invasive, they are found only in urban areas and not in rural or wildlife areas. This study examined how different levels of human exposure impact the behavior of S. carolinensis in its non-native range from two different perspectives by using flight initiation …

Plant-Pollinator Interaction Networks In Remnant And Reconstructed Palouse Prairie In Eastern Wa, Usa, Emma Hoskins

EWU Masters Thesis Collection

Ecological restoration is often focused on re-establishing native plant communities, without considering the larger ecological community, specifically pollinators, despite their being critical to native forb reproduction. Further, ecological restoration has the potential to mitigate global pollinator declines by rebuilding native ecosystems, providing pollinators with floral resources and nesting habitat. This is especially true for prairie restoration, which struggles to establish diverse, abundant native forb communities. The USDA Conservation Reserve Program State Acres for Wildlife Enhancement (CRP SAFE) Palouse Prairie Project provides funding to convert agricultural fields into native Palouse Prairie habitat for the benefit of wildlife. Due to financial and …

The Value Hierarchies Of J.R.R. Tolkien And His Legacy: A Reimagining Of Fantasy Fiction And The Propagation Of Colonial Racism, Alexander Richburg

EWU Masters Thesis Collection

J.R.R. Tolkien’s impact on modern fantasy fiction is remarkable. However, while some of the changes to the genre ushered in by Tolkien’s work are positive, other aspects of his legacy are more problematic. Tolkien’s The Hobbit, The Lord of the Rings, and The Silmarillion are based on his colonial worldview. They are biographical in that Tolkien draws heavily from his life experience to tell his stories. The biographical influence manifests in a hierarchical representation of everything from trees and their ancestry to the elves, humans, dwarves, hobbits, and orcs that populate his fiction. The hierarchies are value structures and the …

Empirical Comparison Of Machine Learning Methods For Wind Power Predictions, Sidny M. Stewart

EWU Masters Thesis Collection

No abstract provided.

Population Assignment Of Entrained Migratory Westslope Cutthroat Trout In North Idaho, Craig D. Wells

EWU Masters Thesis Collection

The Clark Fork-Pend Oreille River basin of northeastern Washington and the Idaho Panhandle historically supported a robust metapopulation of Westslope Cutthroat Trout (WCT) Oncorhynchus clarkii lewisi, a western native salmonid of high cultural and economic value. The construction of impassible hydroelectric dams and smaller in-stream barriers has prevented the return of migratory WCT to spawning tributaries, likely leading to the fragmentation of this metapopulation over the last 100 years. One such impassible barrier is Albeni Falls Dam near Newport, Washington. Completed without fish passage capabilities in 1955, Albeni Falls Dam has been of interest as a site for restoring fish …

Perspectives Of Child Life Specialists On Their Role Supporting Pediatric Psychiatric Boarders, Kerri Sellers

EWU Masters Thesis Collection

No abstract provided.

Scars & Lyres, William Wright Harris

EWU Masters Thesis Collection

No abstract provided.

Cross-Group Friendships And Skin Tone Perceptions, Jhenifa Parker

EWU Masters Thesis Collection

George Allport (1954) coined the term contact hypothesis to explain the relationship between intragroup friendships/interactions and perceptions toward that group. Allport’s hypothesis had been scrutinized as an intervention for reducing prejudices and biases against groups who collectively experience discrimination. This theory was mainly tested in terms of cross-group friendships between individuals of a different ethnicity, racial group, physical ability, and so on; however, very little research has explored this hypothesis in the context of skin tone perceptions. Colorism has had an historical and pervasive impact on individuals categorized as racial/ethnic minorities. This study attempted to bridge the gaps in research …

Assessing The Behavioral Response Of Westslope Cutthroat Trout To Olfactory Cues In A Two-Choice Y-Maze, Hannah Marie Condron

EWU Masters Thesis Collection

The goal of this study was to determine which olfactory cues were most attractive to Westslope Cutthroat Trout Oncorhynchus clarkii lewisi (WCT) in a two-choice Y-maze. WCT used in this study were from Kings Lake and Paqua Creek in Pend Oreille County, Washington, and tested in 2018 and 2019. The different odorants tested in this study were population-specific pheromones produced by WCT from the same population, conspecific pheromones produced by WCT from the second population, and water obtained from each population’s natal stream. The water Kings Lake WCT were reared in for one year at the Spokane Hatchery was also …

Role Of Seed Mixes, Biochar Soil Amendment, And The Soil Seed Bank In Improving Palouse Prairie Restoration, Kristine Snyder

EWU Masters Thesis Collection

The Palouse Prairie Ecoregion of Eastern Washington and Idaho is critically endangered. Eastern Washington University (EWU) has begun a ~120 acre campus prairie restoration; however, there is considerable uncertainty about the most effective restoration approach. Annual seeds and soil organic matter are important for succession and soil moisture, but their roles are unknown for Palouse prairie restoration. Additionally, the soil seedbank of the Palouse ecoregion is widely unknown but could provide insight into methods or species to use for restoration. My research aimed to determine the effects of seed mix diversity, annual seed addition, and soil organic matter (as biochar) …

An Automated Classifier For Child-Directed Speech From Lena Recordings, Janet Y. Bang, George Kachergis, Adriana Weisleder, Virginia A. Marchman

Faculty Research, Scholarly, and Creative Activity

No abstract provided.

Qualified Immunity And Unqualified Assumptions, Teressa Ravenell, Riley H. Ross Iii

Faculty Publications

No abstract provided.

Foreword: Probing The Intersection Of Climate Change And Public Health, Ana Santos Rutschman

Faculty Publications

No abstract provided.

A Property Law Reader: Cases, Questions, And Commentary, 5th Ed., Preface And Table Of Contents, Douglas C. Harris, Jeremy De Beer, Tenille E. Brown, Patricia L. Farnese

All Faculty Publications

Nobody has been more influential over the past generation in the teaching of property law in Canada than Bruce Ziff. His Principles of Property Law is the foundational textbook on the subject. A Property Law Reader: Cases, Questions, and Commentary, which he first published as a sole author in 2004, has become, over three subsequent editions, the most widely used teaching material for property law in the country. Bruce retired from teaching property law in 2019. His retirement left major holes not only at the University of Alberta, where he taught for decades, but also throughout Canada in terms of …

Trust In Science: The Crisis Of Expertise As An Ideological, And Not Only A Scientific Controversy, David S. Caudill

Faculty Publications

Within the so-called "culture wars" dividing our nation politically, there is a law-related division over the trustworthiness of consensus science-the so-called "crisis of expertise." When the science concerning climate change, mask-wearing, or vaccinations becomes politicized, it loses its mooring in scientific evidence and impacts the effectiveness of regulatory law. Perhaps counter-intuitively, however, the solution is likely not to wear "Because Science" t-shirts while insisting on "cold, hard facts" and diagnosing as stupid those who believe the scientific theories of marginalized, minority-view scientists. Indeed, a certain level of modesty-regarding the uncertainties and tentativeness of even the best science-is necessary for the …

Induction Egfr Tyrosine Kinase Inhibitors Prior To Definitive Chemoradiotherapy In Unresectable Stage Iii Egfr-Mutated Non-Small Cell Lung Cancer, Jacqueline V Aredo, Heather A Wakelee, Angela Bik-Yu Hui, Sukhmani K Padda, Nitin D Joshi, H Henry Guo, Aadel Chaudhuri, Maximilian Diehn, Billy W Loo Jr, Joel W Neal

2020-Current year OA Pubs

INTRODUCTION: Increasing evidence suggests that consolidation durvalumab confers limited benefits for patients with stage III EGFR-mutated NSCLC. Induction or maintenance EGFR tyrosine kinase inhibitors (TKIs) added to concurrent chemoradiotherapy (CRT) may optimize definitive treatment, but there are limited data supporting an induction TKI strategy.

METHODS: We evaluated the efficacy and safety of induction EGFR TKIs administered before concurrent CRT in a retrospective series of patients with unresectable locally advanced EGFR-mutated NSCLC. Circulating tumor DNA (ctDNA) analysis was performed on a patient subset using CAPP-seq and correlated with outcomes.

RESULTS: Of six patients, three received erlotinib and three osimertinib as induction …

The Use Of Fulvestrant Before Chemotherapy Improves Survival In Hormone-Positive Breast Cancer: A Real-Life Study, Deni̇z Can Güven, Hasan Çağri Yildirim, Enes Erul, Taha Koray Şahi̇n, İbrahi̇m Yahya Çakir, Oktay Hali̇t Aktepe, Neyran Kertmen, Ömer Di̇zdar, Sercan Aksoy

Turkish Journal of Medical Sciences

Background/aim: We aimed to evaluate the efficacy of fulvestrant and its affecting clinical factors, including the optimal sequencing of fulvestrant and chemotherapy in a real-life cohort. Methods: The data of 256 metastatic hormone-positive breast cancer patients treated with fulvestrant were evaluated. The association of clinical factors with survival was analyzed with Kaplan-Meier and Cox-regression analyses. Results: The median age of patients was 57 years. More than half of the patients used fulvestrant in later lines and after chemotherapy (75.8%). The median progression-free (PFS) and overall survival (OS) of all cohort were 6.05 ± 0.56 and 29.70 ± 1.61 months, respectively. …

Retrospective Comparison Of Flot And Modified Dcf As First-Line Chemotherapy In Metastatic Gastric Adenocarcinoma, Fati̇h Gürler, Deni̇z Can Güven, Ergi̇n Aydemi̇r, Osman Sütcüoğlu, Bedi̇z Kurt İnci̇, Zafer Arik, Şuayi̇b Yalçin, Nuri̇ye Özdemi̇r, Ahmet Özet, Ozan Yazici

Turkish Journal of Medical Sciences

Background/aim: The aim of our study was to compare the efficacy and the safety of the FLOT and the modified DCF (mDCF) regimens in patients with metastatic gastric (GC) and gastroesophageal junction (GEJ) adenocarcinoma as first-line treatment. Materials and methods: The medical records of 72 patients were retrospectively reviewed. Survivals and hematological adverse events of the patients were examined. Factors affecting survivals were analyzed in univariate analysis. A multivariate analysis was performed with the factors contributing to survivals in univariate analysis. Results: The median PFS (mPFS) was 10.1 months (95% CI, 6.8?13.4) in the FLOT arm (n = 33) and …