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2022

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Supporting Latine Children’S Informal Engineering Learning And Spatial Thinking Through Tinkering And Storytelling, Diana Acosta Jan 2022

Supporting Latine Children’S Informal Engineering Learning And Spatial Thinking Through Tinkering And Storytelling, Diana Acosta

Dissertations

In the United States, the Latine community is the fastest growing minority group. Projections estimate that by the year 2060, they will represent 28% of the total population. Yet, Latines continue to be underrepresented and underserved in STEM fields and careers. Providing equitable informal STEM learning opportunities to young children may be a way to increase access and interest in STEM, to address the broader goal of increasing representation. Importantly, for these learning experiences to be truly equitable they must be meaningful and engage everyday cultural practices. Guided by a strengths-based approach, the current study examines how oral stories as …


Facing The Mass Exodus: Reconsidering The Moral Responsibilities For And Obligations Toward Large Numbers Of Refugees In An Age Of Global Crises, Muhammet Ali Asil Jan 2022

Facing The Mass Exodus: Reconsidering The Moral Responsibilities For And Obligations Toward Large Numbers Of Refugees In An Age Of Global Crises, Muhammet Ali Asil

Dissertations

The global refugee crisis has revealed an essential moral question regarding helping the forcibly displaced persons in protracted refugee crises: how do we determine if our community has done “enough” for a particular refugee group? Different answers have been provided to this question. This dissertation takes up this question from a normative standpoint. It develops an ethics-based burden-sharing model, that is, a “meaning-based model,” as a method to determine our political communities’ moral duties toward different refugee groups in various refugee crises. The model challenges the conventional wisdom by claiming that not every community has the same moral obligations toward …


Maternal-Fetal Attachment And Its Relationship To Quality Of Life In Pregnant Women With Diabetes, Cheryl Ann Angel Jan 2022

Maternal-Fetal Attachment And Its Relationship To Quality Of Life In Pregnant Women With Diabetes, Cheryl Ann Angel

Dissertations

Background: Maternal-fetal attachment (MFA) is the bond between a mother and her unborn child during pregnancy. Pregnant women with diabetes are considered high-risk and their numbers are expected to increase as levels of obesity rise and women wait longer to have children. This researcher has observed health care providers instructing pregnant women with diabetes about diabetes self-management (DSM) activities such as “dietary management” and encouraging the women to make those changes for their baby. However, some women remained unable to successfully engage in DSM behaviors despite having exhibited signs of MFA, e.g., expressing “thoughts of the fetus” to health care …


B Cells In The Gut Associated Lymphoid Tissue (Galt), Ameera Bukhari Jan 2022

B Cells In The Gut Associated Lymphoid Tissue (Galt), Ameera Bukhari

Dissertations

The gut-associated lymphoid tissue (GALT) is the largest mass of lymphoid tissue in the body, and it is a unique line of defense where immune cells are in constant contact with gut commensals and pathogens. B lymphocytes constitute most of the lymphatic tissues of the gastrointestinal (GI) tract and they play a critical role in protecting from infections, promoting tolerance, and shaping microbiota in the gut through the production of immunoglobulins (Ig). Previous studies on GALT B cells in human showed that large B cell clones in the body partition into two broad networks: one includes the blood, bone marrow, …


The Role Of Lived Experiences In Culturally Responsive School Leaders’ Administrations: A Phenomenological Case Study, Angela Dolezal Jan 2022

The Role Of Lived Experiences In Culturally Responsive School Leaders’ Administrations: A Phenomenological Case Study, Angela Dolezal

Dissertations

This phenomenological case study explored how the lived experiences of three self-identifiedculturally responsive high school leaders impacted the systemic decisions they made for their school and their students. The study also investigated how these lived experiences informed the leaders’ responses to their stakeholders’ reactions to the systemic decisions. The three school leaders participated in a three-part interview series to answer these three questions (1) What are the personal and educational life histories of three self-identified culturally responsive school leaders in a predominantly White school? (2) How do the life experiences described in the self-identified culturally responsive school leaders’ life histories …


An Ethics Of Doctrinal Emergence: Reading Newman With Augustine And Contemporary Information Theory, Jeffrey John Campbell Jan 2022

An Ethics Of Doctrinal Emergence: Reading Newman With Augustine And Contemporary Information Theory, Jeffrey John Campbell

Dissertations

Jeffrey J. CampbellLoyola University Chicago AN ETHICS OF DOCTRINAL EMERGENCE: READING NEWMAN WITH AUGUSTINE AND CONTEMPORARY INFORMATION THEORY The aim of this essay is to begin the process of a reconfiguration of the theological category of doctrinal development and to integrate an “emergent doctrinal ethics of belief” as an inextricable dimension of this category. Most scholarly writing on doctrinal development has taken place in the wake of the Enlightenment with its focus on epistemology, and doctrine is conceived of as “referencing” a quasi-metaphysical “res.” I attempt to “update” the guiding metaphors of doctrinal development with the goal of moving discussions …


An Interpretive Phenomenological Study Of Women’S Struggles, Hopes And Reasons For Participation In Professional Power-Based Community Organizing In Chicago, Mary Dungy-Akenji Jan 2022

An Interpretive Phenomenological Study Of Women’S Struggles, Hopes And Reasons For Participation In Professional Power-Based Community Organizing In Chicago, Mary Dungy-Akenji

Dissertations

Mary K. L. DungyLoyola University Chicago AN INTERPRETIVE PHENOMENOLOGICAL STUDY OF WOMEN’S STRUGGLES, HOPES AND REASONS FOR PARTICIPATION IN PROFESSIONAL POWER-BASED COMMUNITY ORGANIZING IN CHICAGO Professional power-based community organizing is a practice of grassroots change in which paid organizers guide community members as they band together to make demands on elite groups to redistribute resources (Bobo et. al, 2001; Sites et al., 2007). Conflict-based tactics may be utilized to demand structural improvements from key stakeholders, usually towards progressive political ends that build towards a more just society (Bobo et. al 2001; Wilkinson & D’Angelo, 2019). Community organizing has some roots …


Reclaiming The Patria: Sinarquismo In The United States, 1936-1966, Nathan Ellstrand Jan 2022

Reclaiming The Patria: Sinarquismo In The United States, 1936-1966, Nathan Ellstrand

Dissertations

This dissertation examines the rise and fall of the Catholic, nationalist, and anti-communist Mexican Unión Nacional Sinarquista (UNS or National Synarchist Union) in the U.S. between 1936 and the 1960s. Whereas most scholars study the UNS as a Mexico-specific movement, I examine the organization as a transnational one. This project not only adds to the literature on the UNS, but in Mexican American, Western, and postrevolutionary Mexican history. The individuals that became sinarquistas found refuge from the Mexican church-state conflict in the U.S. in places such as Texas, California, and Chicagoland. The organization’s leadership therefore envisioned an expanded Mexico wherever …


Harnessing The Power Of Interdisciplinary Research With Psychology-Informed Cyberbullying Detection Models, Deborah Hall, Yasin N. Silva, Brittany Wheeler, Lu Cheng, Katie Baumel Jan 2022

Harnessing The Power Of Interdisciplinary Research With Psychology-Informed Cyberbullying Detection Models, Deborah Hall, Yasin N. Silva, Brittany Wheeler, Lu Cheng, Katie Baumel

Computer Science: Faculty Publications and Other Works

Cyberbullying has become increasingly prevalent, particularly on social media. There has also been a steady rise in cyberbullying research across a range of disciplines. Much of the empirical work from computer science has focused on developing machine learning models for cyberbullying detection. Whereas machine learning cyberbullying detection models can be improved by drawing on psychological theories and perspectives, there is also tremendous potential for machine learning models to contribute to a better understanding of psychological aspects of cyberbullying. In this paper, we discuss how machine learning models can yield novel insights about the nature and defining characteristics of cyberbullying and …


The Lick Agn Monitoring Project 2016: Velocity-Resolved Hβ Lags In Luminous Seyfert Galaxies, Vivian U, Aaron J. Barth, H. Alexander Vogler, Hengxiao Guo, Tommaso Treu, Vardha N. Bennert, Gabriela Canalizo, Alexei V. Filippenko, Elinor Gates, Frederick Hamann, Michael D. Joner, Matthew A. Malkan, Anna Pancoast, Peter R. Williams, Jong-Hak Woo, Bela Abolfathi, L. E. Abramson, Stephen F. Armen, Hyun-Jin Bae, Thomas Bohn, Benjamin D. Boizelle, Azalee Bostroem, Andrew Brandel, Thomas G. Brink, Sanyum Channa, M. C. Cooper, Maren Cosens, Edward Donohue, Sean P. Fillingham, Diego González-Buitrago, Goni Halevi, Andrew Halle, Carol E. Hood, Keith Horne, J. Chuck Horst, Maxime De Kouchkovsky, Benjamin Kuhn, Sahana Kumar, Douglas C. Leonard, Donald Loveland, Christina Manzano-King, Ian Mchardy, Raúl Michel, Melanie Kae B. Olaes, Daeseong Park, Songyoun Park, Liuyi Pei, Timothy W. Ross, Jordan N. Runco, Jenna Samuel, Javier Sánchez, Bryan Scott, Remington O. Sexton, Jaejin Shin, Isaac Shivvers, Chance L. Spencer, Benjamin E. Stahl, Samantha Stegman, Isak Stomberg, Stefano Valenti, L. Villafaña, Jonelle L. Walsh, Heechan Yuk, Weikang Zheng Jan 2022

The Lick Agn Monitoring Project 2016: Velocity-Resolved Hβ Lags In Luminous Seyfert Galaxies, Vivian U, Aaron J. Barth, H. Alexander Vogler, Hengxiao Guo, Tommaso Treu, Vardha N. Bennert, Gabriela Canalizo, Alexei V. Filippenko, Elinor Gates, Frederick Hamann, Michael D. Joner, Matthew A. Malkan, Anna Pancoast, Peter R. Williams, Jong-Hak Woo, Bela Abolfathi, L. E. Abramson, Stephen F. Armen, Hyun-Jin Bae, Thomas Bohn, Benjamin D. Boizelle, Azalee Bostroem, Andrew Brandel, Thomas G. Brink, Sanyum Channa, M. C. Cooper, Maren Cosens, Edward Donohue, Sean P. Fillingham, Diego González-Buitrago, Goni Halevi, Andrew Halle, Carol E. Hood, Keith Horne, J. Chuck Horst, Maxime De Kouchkovsky, Benjamin Kuhn, Sahana Kumar, Douglas C. Leonard, Donald Loveland, Christina Manzano-King, Ian Mchardy, Raúl Michel, Melanie Kae B. Olaes, Daeseong Park, Songyoun Park, Liuyi Pei, Timothy W. Ross, Jordan N. Runco, Jenna Samuel, Javier Sánchez, Bryan Scott, Remington O. Sexton, Jaejin Shin, Isaac Shivvers, Chance L. Spencer, Benjamin E. Stahl, Samantha Stegman, Isak Stomberg, Stefano Valenti, L. Villafaña, Jonelle L. Walsh, Heechan Yuk, Weikang Zheng

Physics

We carried out spectroscopic monitoring of 21 low-redshift Seyfert 1 galaxies using the Kast double spectrograph on the 3 m Shane telescope at Lick Observatory from 2016 April to 2017 May. Targeting active galactic nuclei (AGNs) with luminosities of λLλ(5100 Å) ≈ 1044 erg s−1 and predicted Hβ lags of ∼20–30 days or black hole masses of 107–108.5 M⊙, our campaign probes luminosity-dependent trends in broad-line region (BLR) structure and dynamics as well as to improve calibrations for single-epoch estimates of quasar black hole masses. Here we present the first results from the campaign, including …


Attempting Genetic Inference From Directional Asymmetry During Convergent Hindlimb Reduction In Squamates, Samantha Swank, Ethan Elazegui, Sophia Janidlo, Thomas J. Sanger, Michael A. Bell, Yoel E. Stuart Jan 2022

Attempting Genetic Inference From Directional Asymmetry During Convergent Hindlimb Reduction In Squamates, Samantha Swank, Ethan Elazegui, Sophia Janidlo, Thomas J. Sanger, Michael A. Bell, Yoel E. Stuart

Biology: Faculty Publications and Other Works

Loss and reduction in paired appendages are common in vertebrate evolution. How often does such convergent evolution depend on similar developmental and genetic pathways? For example, many populations of the threespine stickleback and ninespine stickleback (Gasterosteidae) have independently evolved pelvic reduction, usually based on independent mutations that caused reduced Pitx1 expression. Reduced Pitx1 expression has also been implicated in pelvic reduction in manatees. Thus, hindlimb reduction stemming from reduced Pitx1 expression has arisen independently in groups that diverged tens to hundreds of millions of years ago, suggesting a potential for repeated use of Pitx1 across vertebrates. Notably, hindlimb reduction based …


Discordant Population Structure Among Rhizobium Divided Genomes And Their Legume Hosts, Alex B. Riley, Michael A. Grillo, Brendan Epstein, Peter Tiffin, Katy D. Heath Jan 2022

Discordant Population Structure Among Rhizobium Divided Genomes And Their Legume Hosts, Alex B. Riley, Michael A. Grillo, Brendan Epstein, Peter Tiffin, Katy D. Heath

Biology: Faculty Publications and Other Works

Symbiosis often occurs between partners with distinct life history characteristics and dispersal mechanisms. Many bacterial symbionts have genomes comprising multiple replicons with distinct rates of evolution and horizontal transmission. Such differences might drive differences in population structure between hosts and symbionts and among the elements of the divided genomes of bacterial symbionts. These differences might, in turn, shape the evolution of symbiotic interactions and bacterial evolution. Here we use whole genome resequencing of a hierarchically structured sample of 191 strains of Sinorhizobium meliloti collected from 21 locations in southern Europe to characterize population structures of this bacterial symbiont, which forms …


Gut Dysbiosis In Cutaneous T-Cell Lymphoma Is Characterized By Shifts In Relative Abundances Of Specific Bacterial Taxa And Decreased Diversity In More Advanced Disease, Madeline J. Hooper, T.M. Lewitt, Y. Pang, F.L. Veon, G.E Chlipala, L. Feferman, S.J. Green, D. Sweeney, K.T. Bagnowski, Michael B. Burns, P.C. Seed, J. Choi, J. Guitart, X.A. Zhou Jan 2022

Gut Dysbiosis In Cutaneous T-Cell Lymphoma Is Characterized By Shifts In Relative Abundances Of Specific Bacterial Taxa And Decreased Diversity In More Advanced Disease, Madeline J. Hooper, T.M. Lewitt, Y. Pang, F.L. Veon, G.E Chlipala, L. Feferman, S.J. Green, D. Sweeney, K.T. Bagnowski, Michael B. Burns, P.C. Seed, J. Choi, J. Guitart, X.A. Zhou

Biology: Faculty Publications and Other Works

Background Cutaneous T-cell lymphoma (CTCL) patients often suffer from recurrent skin infections and profound immune dysregulation in advanced disease. The gut microbiome has been recognized to influence cancers and cutaneous conditions; however, it has not yet been studied in CTCL.ObjectivesTo investigate the gut microbiome in patients with CTCL and in healthy controls.MethodsA case-control study was conducted between January 2019 and November 2020 at Northwestern’s busy multidisciplinary CTCL clinic (Chicago, Illinois, USA) utilizing 16S ribosomal RNA gene amplicon sequencing and bioinformatics analyses to characterize the microbiota present in fecal samples of CTCL patients (n = 38) and age-matched healthy controls (n …


Runoff And Discharge Pathways Of Microplastics Into Freshwater Ecosystems: A Systematic Review And Meta-Analysis, J. Wang, K. Bucci, P. A. Helm, T. Hoellein, M. J. Hoffman, R. Rooney, C. M. Rochman Jan 2022

Runoff And Discharge Pathways Of Microplastics Into Freshwater Ecosystems: A Systematic Review And Meta-Analysis, J. Wang, K. Bucci, P. A. Helm, T. Hoellein, M. J. Hoffman, R. Rooney, C. M. Rochman

Biology: Faculty Publications and Other Works

Although many studies have focused on the importance of littering and (or) illegal dumping as a source of plastic pollution to freshwater, other relevant pathways should be considered, including wastewater, stormwater runoff, industrial effluent/runoff, and agricultural runoff. Here, we conducted a meta-analysis focused on these four pathways. We quantified the number of studies, amount and characteristics of microplastics reported, and the methods used to sample and measure microplastics from each pathway. Overall, we found 121 studies relevant to our criteria, published from 2014 to 2020. Of these, 54 (45%) quantified and characterized microplastics in discharge pathways. Although most focused on …


Microplastic Accumulation In Riverbed Sediment Via Hyporheic Exchange From Headwaters To Mainstems, Jennifer D. Drummond, Uwe Schneidewind, Angang Li, Timothy J. Hoellein, Stefan Krause, Aaron I. Packman Jan 2022

Microplastic Accumulation In Riverbed Sediment Via Hyporheic Exchange From Headwaters To Mainstems, Jennifer D. Drummond, Uwe Schneidewind, Angang Li, Timothy J. Hoellein, Stefan Krause, Aaron I. Packman

Biology: Faculty Publications and Other Works

In rivers, small and lightweight microplastics are transported downstream, but they are also found frequently in riverbed sediment, demonstrating long-term retention. To better understand microplastic dynamics in global rivers from headwaters to mainstems, we developed a model that includes hyporheic exchange processes, i.e., transport between surface water and riverbed sediment, where microplastic retention is facilitated. Our simulations indicate that the longest microplastic residence times occur in headwaters, the most abundant stream classification. In headwaters, residence times averaged 5 hours/km but increased to 7 years/km during low-flow conditions. Long-term accumulation for all stream classifications averaged ~5% of microplastic inputs per river …


Testimonios De Las Atravesadas: A Borderland Existence Of Women Of Color Faculty, Katherine S. Cho, Racheal M. Banda, Erica Fernandez, Brittany Aronson Jan 2022

Testimonios De Las Atravesadas: A Borderland Existence Of Women Of Color Faculty, Katherine S. Cho, Racheal M. Banda, Erica Fernandez, Brittany Aronson

Education: School of Education Faculty Publications and Other Works

The temporalities of COVID-19 and resultant economic crisis, along with increased visibility of white supremacy and anti-Blackness, have exacerbated the longstanding chal-lenges Women of Color (WOC) faculty experience, particu-larly around negotiating labor and navigating the academy. Through Anzaldúa's borderlands framework, and an inter-woven methodology of testimonios and pláticas, this paper's findings illuminate how the fixed, shifting, and messy bound-aries of academic work have, especially for WOC faculty working through COVID-19, violated the limits of the personal and professional, intruded into the homes as sacred spaces, and continued and expanded demands to provide labor. Institutions have placated these fraught borders with …


A Mixed Method Study Of Teachers' Appraisals Of Student Wellness Services And Supports During Covid-19, Tasha M. Childs, Elizabeth Levine Brown Phd, Naomi Brown, Aidyn L. Iachini Phd, Kate L. Phillippo, Linda Galib, Audra Parker, Ken Fujimoto Phd Jan 2022

A Mixed Method Study Of Teachers' Appraisals Of Student Wellness Services And Supports During Covid-19, Tasha M. Childs, Elizabeth Levine Brown Phd, Naomi Brown, Aidyn L. Iachini Phd, Kate L. Phillippo, Linda Galib, Audra Parker, Ken Fujimoto Phd

Education: School of Education Faculty Publications and Other Works

BACKGROUNDUnderstanding teachers' appraisals of student wellness services and supports during COVID-19 is essential to strengthening services and improving student health outcomes. This mixed-method study aimed to examine US PK-12 teachers' appraisals of student wellness services and supports during COVID-19.METHODSThis study focuses on qualitative data from 291 teachers' open-ended responses to the question: “What do you wish your school leaders knew about this (wellness support) aspect of your work?” and whose responses described wellness services and supports. A qualitative content analysis was conducted by an interdisciplinary research team using open- and axial coding.RESULTSThree main themes emerged. (1) insufficient access to mental …


Bias Mitigation For Toxicity Detection Via Sequential Decisions, Lu Cheng, Ahmadreza Mosallanezhad, Yasin N. Silva, Deborah Hall, Huan Liu Jan 2022

Bias Mitigation For Toxicity Detection Via Sequential Decisions, Lu Cheng, Ahmadreza Mosallanezhad, Yasin N. Silva, Deborah Hall, Huan Liu

Computer Science: Faculty Publications and Other Works

Increased social media use has contributed to the greater prevalence of abusive, rude, and offensive textual comments. Machine learning models have been developed to detect toxic comments online, yet these models tend to show biases against users with marginalized or minority identities (e.g., females and African Americans). Established research in debiasing toxicity classifiers often (1) takes a static or batch approach, assuming that all information is available and then making a one-time decision; and (2) uses a generic strategy to mitigate different biases (e.g., gender and racial biases) that assumes the biases are independent of one another. However, in real …


Dbsnap 2: New Features To Construct Database Queries By Snapping Blocks, Yasin N. Silva, Alexis Loza, Humberto Razente Jan 2022

Dbsnap 2: New Features To Construct Database Queries By Snapping Blocks, Yasin N. Silva, Alexis Loza, Humberto Razente

Computer Science: Faculty Publications and Other Works

Block-based environments for creating computer programs have become very useful learning tools in computer science as they enable focusing on the logic of a program rather than on its syntactical details. While most block-based environments support conventional (imperative) instructions, a few tools have been proposed to create database queries. One of these tools is DBSnap, a highly dynamic and open-source tool to create database query trees by dragging and connecting visual blocks representing datasets and database operators. In this paper, we introduce DBSnap 2, an extension of DBSnap that provides a set of improvements to facilitate the creation of simple …


Using Peer Review To Improve English As A Second Language College Students' Writing Scores, Mengjie Wei Jan 2022

Using Peer Review To Improve English As A Second Language College Students' Writing Scores, Mengjie Wei

Doctoral Dissertations

This study was conducted to examine the effectiveness of peer-review in college English as Second Language writing classes to improve ESL students’ writing scores. It also investigated a statistically significant difference in college ESL students’ writing scores between those who use the self-check list and peer review worksheet and those who only use the self-check list in writing paragraphs and essays. More specifically, this study was conducted to determine the influence of different areas on students’ English writing scores, i.e., format/content/structure, grammar, vocabulary, and spelling. In addition, this study explored students’ attitudes and opinions on peer-review in writing class.

This …


Genocide In East Turkestan: Exploring The Perspectives Of Uyghurs In The Diaspora And Their Resistance To Chinese State Violence, Lina Semyonovna Lenberg Jan 2022

Genocide In East Turkestan: Exploring The Perspectives Of Uyghurs In The Diaspora And Their Resistance To Chinese State Violence, Lina Semyonovna Lenberg

Doctoral Dissertations

The Uyghurs of Xinjiang Uyghur Autonomous Region—or East Turkestan, as many Uyghurs call their Indigenous homeland in northwestern China, are a Muslim ethnic group whose culture and identity are being systematically destroyed by the Chinese state. Since 2016, Uyghurs have been imprisoned in China’s “re-education camps” on an enormous scale, numbering up to three million. Uyghurs have experienced discrimination and marginalization in China for many years, yet relatively little attention has been given to what has now become a set of gross human rights violations amounting to crimes against humanity and genocide. The purpose of this study was twofold. First, …


The U.S. Government's Program Of Welfare For The Wealthy, Stanley F. Stasch Jan 2022

The U.S. Government's Program Of Welfare For The Wealthy, Stanley F. Stasch

School of Business: Faculty Publications and Other Works

No abstract provided.


Feminist Academic Organizations: Challenging Sexism Through Collective Mobilizing Across Research, Support, And Advocacy, Lauren Gurrieri, Andrea Prothero, Shona Bettany, Susan Dobscha, Jenna M. Drenten, Shelagh Ferguson, Stacey Finkelstein, Laura Mcvey, Nacima Ourahmoune, Laurel Steinfield, Linda Tuncay Zayer Jan 2022

Feminist Academic Organizations: Challenging Sexism Through Collective Mobilizing Across Research, Support, And Advocacy, Lauren Gurrieri, Andrea Prothero, Shona Bettany, Susan Dobscha, Jenna M. Drenten, Shelagh Ferguson, Stacey Finkelstein, Laura Mcvey, Nacima Ourahmoune, Laurel Steinfield, Linda Tuncay Zayer

School of Business: Faculty Publications and Other Works

This paper examines the establishment of a feminist academic organization, GENMAC (Gender, Markets, and Consumers; genmac.co), serving gender scholars in business schools and related fields. In so doing, it builds on the emerging literature of feminist academic organizations, as situated within feminist organizational studies (FOS). Through a feminist case study and by assessing the reflections of GENMAC's board members, we tell the story of the emergence of GENMAC and detail the tensions the organization encountered as it formally established itself as a feminist organization within the confines of a business school setting, a patriarchal system, and a neoliberal university paradigm. …


Biocatalytic Intramolecular C−H Aminations Via Engineered Heme Proteins: Full Reaction Pathways And Axial Ligand Effects, Yang Wei, Melissa Conklin, Yong Zhang Jan 2022

Biocatalytic Intramolecular C−H Aminations Via Engineered Heme Proteins: Full Reaction Pathways And Axial Ligand Effects, Yang Wei, Melissa Conklin, Yong Zhang

Chemistry: Faculty Publications and Other Works

Engineered heme protein biocatalysts provide an efficient and sustainable approach to develop amine-containing compounds through C−H amination. A quantum chemical study to reveal the complete heme catalyzed intramolecular C−H amination pathway and protein axial ligand effect was reported, using reactions of an experimentally used arylsulfonylazide with hemes containing L=none, SH−, MeO−, and MeOH to simulate no axial ligand, negatively charged Cys and Ser ligands, and a neutral ligand for comparison. Nitrene formation was found as the overall rate-determining step (RDS) and the catalyst with Ser ligand has the best reactivity, consistent with experimental reports. Both RDS and non-RDS (nitrene transfer) …


Zero Tolerance Atrocity Crimes Against Migrant Children And Families In The United States: An Accountability Framework For Family Separation, Sarah Diaz Jd, Llm, Jenny Lee Phd Jan 2022

Zero Tolerance Atrocity Crimes Against Migrant Children And Families In The United States: An Accountability Framework For Family Separation, Sarah Diaz Jd, Llm, Jenny Lee Phd

Center for the Human Rights of Children

No abstract provided.


Molecular Mechanisms Of Oxidative Stress-Induced Corneal Damage And The Use Of Antioxidants And Therapeutics, Anita Kirti Ghosh Jan 2022

Molecular Mechanisms Of Oxidative Stress-Induced Corneal Damage And The Use Of Antioxidants And Therapeutics, Anita Kirti Ghosh

Dissertations

Dry eye disease represents an urgent unmet clinical need. This dissertation explores the underlying pathophysiological mechanisms of ocular surface disease in small and large animal models and provides feasibility for the development of antioxidants as novel therapeutics for dry eye disease. Dry eye disease affects 50 million Americans every year, and costs about $55 billion annually in the USA. The disease manifests as ocular irritation, burning, foreign body sensation, and blurry/cloudy vision. While it is widely accepted that oxidative stress plays a critical role in the pathophysiology of the disease, little is understood about the underlying molecular mechanisms. The purpose …


A Phenomenological Study Of Catholic Priests Working And Headteachers In Government - Funded Catholic Secondary Schools, Joseph Kaye Jan 2022

A Phenomenological Study Of Catholic Priests Working And Headteachers In Government - Funded Catholic Secondary Schools, Joseph Kaye

Dissertations

ABSTRACT

The purpose of this qualitative phenomenological study is to explore the skills, behaviors and lived experience of priests who are headteachers in government-funded Catholic secondary schools in Butare Catholic diocese. This study might help the bishop and diocesan policy makers in identifying the type of formation, skills and behaviors priests need to be effective headteachers in Catholic schools. To achieve the purpose of this study, I used a phenomenological methodology to collect and analyze the data. The participants in this study are priests who are headteachers in government-funded Catholic secondary schools of Butare Catholic diocese. The major goals of …


Abl2 Promotes Alcohol-Associated Liver Disease Via Ppar Gamma Regulation, Gregory Malnassy Jan 2022

Abl2 Promotes Alcohol-Associated Liver Disease Via Ppar Gamma Regulation, Gregory Malnassy

Dissertations

Alcohol-associated liver disease (AALD) is an umbrella term for a spectrum of diseases resulting from chronic alcohol (e.g. ethanol) abuse ranging in severity from reversible conditions such as alcohol-induced steatosis to advanced and largely irreversible liver pathologies including alcoholic steatohepatitis (ASH), alcoholic hepatitis (AH), fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). AALD is one of the primary causes of chronic liver disease worldwide and accounts for 44% of liver disease deaths in the United States. Drinking rates, both in the United States and globally, have increased year over year for the past three decades, a trend which has resulted in significantly …


Imagining Otherwise: Designing And Implementing A High School Writing Center, Sheldon Cale Krieger Jan 2022

Imagining Otherwise: Designing And Implementing A High School Writing Center, Sheldon Cale Krieger

Dissertations

This study explored the work of planning and opening a new high school writing center in a school with a student population predominantly of students of color. The action research study occurred over the first twelve weeks of the writing center opening to better understand how such work might begin to disrupt oppressive systems and structures inherent in the school site as well as education at large. The arts-based methodology included daily reflective journals, a series of four collages, and document analysis. The study utilized critical imagining as its theoretical framework by combining tenets of critical race theory (CRT) with …


Las Chingonas: An Ecological Approach To Latina Student Mothers’ Journey Through College, Emely Elizabeth Medina-Rodriguez Jan 2022

Las Chingonas: An Ecological Approach To Latina Student Mothers’ Journey Through College, Emely Elizabeth Medina-Rodriguez

Dissertations

Women with children are one of the growing student sub-populations in higher education. However, the support student mothers receive in colleges and universities has been historically unreliable and their experiences in college have not been studied in depth. This is especially true for student mothers from minoritized backgrounds with differing racial, ethnic, sexual, gender, and ability identities. This research aims to understand the experiences Latina graduate student mothers from an ecological and critical perspective. Guided by Critical Human Ecology and Black Feminist Thought, eight open-ended interviews were conducted and analyzed. Themes and categories came out of the patterns in the …