Digital Commons Network^™

Association Of Body Mass Index In Midlife With Morbidity Burden In Older Adulthood And Longevity, Sadiya S. Khan, Amy E. Krefman, Lihui Zhao, Lei Liu, Anna Chorniy, Martha L. Daviglus, Cuiping Schiman, Kiang Liu, Tina Shih, Daniel Garside, Thanh-Huyen T. Vu, Donald M. Lloyd-Jones, Norrina B. Allen

Open Access Publications

Importance: Abundant evidence links obesity with adverse health consequences. However, controversies persist regarding whether overweight status compared with normal body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) is associated with longer survival and whether this occurs at the expense of greater long-term morbidity and health care expenditures.

Objective: To examine the association of BMI in midlife with morbidity burden, longevity, and health care expenditures in adults 65 years and older.

Design, Setting, and Participants: Prospective cohort study at the Chicago Heart Association Detection Project in Industry, with baseline in-person examination between November 1967 …

Association Of Multidimensional Poverty With Dementia In Adults Aged 50 Years Or Older In South Africa, Jean-Francois Trani, Jacqueline Moodley, May Thu Thu Maw, Ganesh M. Babulal

Open Access Publications

Importance: Limited research exists investigating the association between multidimensional poverty and dementia in low-and middle-income countries (LMICs).

Objective: To investigate the association between multidimensional poverty and dementia among adults aged 50 years or older living in South Africa.

Design, Setting, and Participants: This cross-sectional study was conducted in Soweto, Johannesburg, South Africa, between November 11, 2019, and February 28, 2020. Participants included 227 adults aged 50 years or older. Data analysis was concluded from August 1 to 30, 2021.

Exposures: Multidimensional poverty included 7 dimensions that are central to well-being (education, health, economic activity, living standards, social participation, fair treatment, …

De Novo Missense Variants In Fbxo11 Alter Its Protein Expression And Subcellular Localization, Anne Gregor, Marwan Shinawi, Et Al

Open Access Publications

Recently, others and we identified de novo FBXO11 (F-Box only protein 11) variants as causative for a variable neurodevelopmental disorder (NDD). We now assembled clinical and mutational information on 23 additional individuals. The phenotypic spectrum remains highly variable, with developmental delay and/or intellectual disability as the core feature and behavioral anomalies, hypotonia and various facial dysmorphism as frequent aspects. The mutational spectrum includes intragenic deletions, likely gene disrupting and missense variants distributed across the protein. To further characterize the functional consequences of FBXO11 missense variants, we analyzed their effects on protein expression and localization by overexpression of 17 different mutant …

An Overview Of Treatment Options For Patients With Relapsed/Refractory Multiple Myeloma And Renal Impairment, Meletios A Dimopoulos, Joseph Mikhael, Evangelos Terpos, Xavier Leleu, Philippe Moreau, Joan Bladé, Jin Seok Kim, Keith Stockerl-Goldstein, Paul G Richardson

Open Access Publications

Renal impairment (RI) is a relatively common complication of multiple myeloma, which increases in frequency as disease becomes more advanced and recovery of renal function becomes less likely as patients progress through lines of therapy. Clinical trials in the relapsed/refractory multiple myeloma (RRMM) setting have not uniformly included patients with RI or robustly reported their outcomes. Here, we review existing data among patients with RI and RRMM across drug classes (including immunomodulatory agents, proteasome inhibitors, monoclonal antibodies, antibody-drug conjugates, chimeric antigen receptor T-cell therapies, and exportin-1 inhibitor) to provide an improved understanding of available treatment options for this important population. …

Salaries, Degrees, And Babies: Trends In Fertility By Income And Education Among Japanese Men And Women Born 1943-1975-Analysis Of National Surveys, Cyrus Ghaznavi, Haruka Sakamoto, Lisa Yamasaki, Shuhei Nomura, Daisuke Yoneoka, Kenji Shibuya, Peter Ueda

Open Access Publications

BACKGROUND: While fertility rates have decreased during the second half of the 20th century in Japan, little is known regarding trends in the number of children that men and women have across birth cohorts and whether these differ by education and income.

METHODS: We used data from four rounds of the National Fertility Survey (1992, 2005, 2010 and 2015) and included men and women aged 40-49 years (16728 men and 17628 women). By 5-year birth cohorts, we assessed the distribution of number of children (0, 1, 2 and 3 or more) and total fertility (the mean number of children) at …

Treatment Patterns And Outcomes Following Disease Progression On Anti-Pd-1 Therapies For Advanced Melanoma, Beth L. Nordstrom, Melissa Hamilton, Jenna M. Collins, Dennis Earle, Ying Zhang, Shivani Srivastava, Leonel Hernandez-Aya

Open Access Publications

No abstract provided.

Nia Long Life Family Study: Objectives, Design, And Heritability Of Cross-Sectional And Longitudinal Phenotypes, Mary K. Wojczynski, Shiow Jiuan Lin, Paola Sebastiani, Thomas T. Perls, Joseph Lee, Alexander Kulminski, Anne Newman, Joe M. Zmuda, Kaare Christensen, Michael A. Province

Open Access Publications

The NIA Long Life Family Study (LLFS) is a longitudinal, multicenter, multinational, population-based multigenerational family study of the genetic and nongenetic determinants of exceptional longevity and healthy aging. The Visit 1 in-person evaluation (2006-2009) recruited 4 953 individuals from 539 two-generation families, selected from the upper 1% tail of the Family Longevity Selection Score (FLoSS, which quantifies the degree of familial clustering of longevity). Demographic, anthropometric, cognitive, activities of daily living, ankle-brachial index, blood pressure, physical performance, and pulmonary function, along with serum, plasma, lymphocytes, red cells, and DNA, were collected. A Genome Wide Association Scan (GWAS) (Ilumina Omni 2.5M …

Dysregulation Of The Leukocyte Signaling Landscape During Acute Covid-19, Isaiah R. Turnbull, Anja Fuchs, Kenneth E. Remy, Michael P. Kelly, Elfaridah P. Frazier, Sarbani Ghosh, Shin-Wen Chang, Monty B. Mazer, Annie Hess, Jennifer M. Leonard, Mark H. Hoofnagle, Marco Colonna, Richard S. Hotchkiss

Open Access Publications

The global COVID-19 pandemic has claimed the lives of more than 750,000 US citizens. Dysregulation of the immune system underlies the pathogenesis of COVID-19, with inflammation mediated tissue injury to the lung in the setting of suppressed systemic immune function. To define the molecular mechanisms of immune dysfunction in COVID-19 we utilized a systems immunology approach centered on the circulating leukocyte phosphoproteome measured by mass cytometry. We find that although COVID-19 is associated with wholesale activation of a broad set of signaling pathways across myeloid and lymphoid cell populations, STAT3 phosphorylation predominated in both monocytes and T cells. STAT3 phosphorylation …

Steroid Hormone Signaling Activates Thermal Nociception During Drosophila Peripheral Nervous System Development, Jacob S. Jaszczak, Laura Devault, Lily Yeh Jan, Yuh Nung Jan

Open Access Publications

Sensory neurons enable animals to detect environmental changes and avoid harm. An intriguing open question concerns how the various attributes of sensory neurons arise in development.

Association Between Hospital Private Equity Acquisition And Outcomes Of Acute Medical Conditions Among Medicare Beneficiaries, Marcelo Cerullo, Kelly Yang, Karen E. Joynt Maddox, Ryan C. Mcdevitt, James M. Roberts, Anaeze C. Offodile

Open Access Publications

Importance: As private equity (PE) acquisitions of short-term acute care hospitals (ACHs) continue, their impact on the care of medically vulnerable older adults remains largely unexplored.

Objective: To investigate the association between PE acquisition of ACHs and access to care, patient outcomes, and spending among Medicare beneficiaries hospitalized with acute medical conditions.

Design, Setting, and Participants: This cross-sectional study used a generalized difference-in-differences approach to compare 21 091 222 patients admitted to PE-acquired vs non-PE-acquired short-term ACHs between January 1, 2001, and December 31, 2018, at least 3 years before to 3 years after PE acquisition. The analysis was conducted …

Fracture Healing Is Delayed In The Absence Of Gasdermin-Interleukin-1 Signaling, Kai Sun, Chun Wang, Jianqiu Xiao, Michael D. Brodt, Luorongxin Yuan, Tong Yang, Yael Alippe, Huimin Hu, Dingjun Hao, Yousef Abu-Amer, Matthew J. Silva, Jie Shen, Gabriel Mbalaviele

Open Access Publications

Amino-terminal fragments from proteolytically cleaved gasdermins (GSDMs) form plasma membrane pores that enable the secretion of interleukin-1β (IL-1β) and IL-18. Excessive GSDM-mediated pore formation can compromise the integrity of the plasma membrane thereby causing the lytic inflammatory cell death, pyroptosis. We found that GSDMD and GSDME were the only GSDMs that were readily expressed in bone microenvironment. Therefore, we tested the hypothesis that GSDMD and GSDME are implicated in fracture healing owing to their role in the obligatory inflammatory response following injury. We found that bone callus volume and biomechanical properties of injured bones were significantly reduced in mice lacking …

Tourette Syndrome Research Highlights From 2020, Andreas Hartmann, Cyril Atkinson-Clement, Christel Depienne, Kevin Black

Open Access Publications

We present here research from 2020 relevant to Tourette syndrome (TS). The authors briefly summarize a few reports they consider most important or interesting.

Is A Framework Of Support Enough? Undergraduate Research For Online Stem Students, Emily Faulconer, Brent Terwilliger, Robert Deters, Kelly George

Publications

While undergraduate research is known as a high-impact practice, little research has been conducted for the online educational setting. Early research suggests that online students and faculty have similar interest in undergraduate research as their residential (face-to-face) counterparts. This point of view presents the framework of support developed for fully online students distributed globally and shares some of the challenges faced in online undergraduate research, including the issue of low recruitment (despite stated interest) that could be exacerbated by the COVID-19 pandemic.

Univariate And Multivariate Lstm Models For One Step And Multistep Pv Power Forecasting, Tariq Limouni, Reda Yaagoubi, Khalid Bouziane, Khalid Guissi, El Houssain Baali

Research Outputs: 2025-Present

The energy demand is increasing due to population growth and economic development. To satisfy this energy demand, the use of renewable energy is essential to face global warming and the depletion of fossil fuels. Photovoltaic energy is one of the renewable energy sources, widely used by several countries over the world. The integration of PV energy into the grid brings significant benefits to the economy and environment, however, high penetration of this energy also brings some challenges to the stability of the electrical grid, due to the intermittency of solar energy. To overcome this issue, the use of a forecasting …

Climbing The Anki Mountain, One (Review) Step At A Time: A Written And Video-Based Guide On Using Anki In Medical School To Enhance Knowledge Acquisition And Retention, Alexander Tu, Tiffany Truong, Avi Prajapati

EMET Projects

No abstract provided.

The Corporate Forum, Sergio Alberto Gramitto Ricci, Christina M. Sautter

Hofstra Law Faculty Scholarship

No abstract provided.

Stem Inqueery: How Communion And Feminine Gender Expression Affects Lgbtq Individuals Pursuing Stem, Jasmine Elise Graham

UNF Graduate Theses and Dissertations

Previous research has examined why some US students, Black, Latinx, and women are underrepresented in science, technology, engineering, and mathematics (STEM). However, at least 7.1% lesbian, gay, bisexual, transgender, and queer (LGBTQ) individuals live in the US, so what about the LGBTQ community pursuing STEM? We know that STEM careers are stereotypically seen as agentic and masculine instead of communal and feminine although LGBTQ individuals desire community within STEM and want to express their femininity. The current study examines how perceived communal opportunities in STEM and feminine gender expression are related to feelings of belonging and motivation to pursue STEM. …

Implementation Of A Transitions Of Care Nutrition Intervention For Malnourished Patients, Nina Rocca

UNF Graduate Theses and Dissertations

The topic of Transitions of Care (TOC) has been investigated by physician and nursing professions for years, while only more recently by nutrition professionals. Registered Dietitians are not always involved in TOC planning. RDs can play an important role in TOC by communicating patients’ nutrition information across health care settings, especially for patients with malnutrition. The primary aim was to use a CDC based process evaluation to evaluate if a case management, nursing focused care transitions framework, adapted for a TOC nutrition intervention, can result in a successful intervention implementation. The secondary aim was to use a CDC outcomes evaluation, …

Exploring The Health Outcomes And Patient’S Viewpoint Of Pediatric Patients Receiving Medical Nutrition Therapy Visits With In-Person, Telephonic, And Tele-Video Modalities At A Rural Community Health Center, Valerie L. Muehleman

UNF Graduate Theses and Dissertations

The Covid-19 pandemic advanced telephonic (TP) and tele-video (TV) visits for medical nutrition therapy (MNT). This study explored the health outcomes and patient’s viewpoints of MNT by modalities in a community health center (CHC). Participants ranged in age from 1-18 years, diagnosed with overweight/obesity, and received MNT from a registered dietitian nutritionist (RDN) from January 1, 2019 to August 31, 2021. Health outcomes measured were health goal achievement, BMI percentile, pre/post lipid panel, and A1C%. Show/no-show rates and demographic characteristics of gender, age, race, insurance, county, language, and ethnicity were also compared by the visit modality. Ten interviews in the …

Higher Education Information And Communication Technology Implementation Project Success: The Effect Of Organizational Culture, Reginald W. Brinson

UNF Graduate Theses and Dissertations

This dissertation employed a non-experimental quantitative research method to examine the relationship between organizational culture and perceptions of Information and Communication Technology implementation project success in higher education institutions. The study used Sociotechnical Systems Theory to frame the higher education institution’s work system and the Competing Values Framework (CVF) in distinguishing the cultures of the institution, its colleges/divisions, and its departments to determine if differences in culture tendencies impacted faculty, staff, and administrators’ perception of project success. A survey consisting of the Organizational Culture Assessment Instrument (OCAI, © Kim Cameron) and a Project Success scale was used to gather data. …

Characterizing Implied Volatility Functions From Agricultural Options Markets, Andrew M. Mckenzie, Michael R. Thomsen, Michael K. Adjemian

Agricultural Economics and Agribusiness Faculty Publications and Presentations

We provide the first comprehensive characterization and comparison of implied volatility functions for five major agricultural options markets—corn, soybeans, soft red winter wheat, live cattle, and feeder cattle—using intraday tick data. Our results show that cattle markets exhibit a distinct leftward skew, which is puzzling and indicates that out-of-the-money traded put options are theoretically overpriced. In contrast, we find that grain market implied volatility functions display a flatter, less pronounced smile pattern. We examine market sentiment induced short-term hedging pressures using Commodity Futures Trading Commission reports, and market uncertainty around Cattle on Feed reports, as potential causes of the cattle …

Mammals Adjust Diel Activity Across Gradients Of Urbanization, Travis Gallo, Mason Fidino, Brian Gerber, Adam A. Ahlers, Julia L. Angstmann, Max Amaya, Amy L. Concilio, David Drake, Danielle Gay, Elizabeth W. Lehrer, Maureen H. Murray, Travis J. Ryan, Colleen Cassady St. Clair, Carmen M. Salsbury, Heather A. Sander, Theodore Stankowich, Jaque Williamson, J. Amy Belaire, Kelly Simon, Seth B. Magle

Natural Resources Science Faculty Publications

Time is a fundamental component of ecological processes. How animal behavior changes over time has been explored through well-known ecological theories like niche partitioning and predator–prey dynamics. Yet, changes in animal behavior within the shorter 24-hr light–dark cycle have largely gone unstudied. Understanding if an animal can adjust their temporal activity to mitigate or adapt to environmental change has become a recent topic of discussion and is important for effective wildlife management and conservation. While spatial habitat is a fundamental consideration in wildlife management and conservation, temporal habitat is often ignored. We formulated a temporal resource selection model to quantify …

Collaboration Is Key: Using Interdisciplinary Assessment To Improve Wildlife Management Practices, Public Engagement In Science, And Science Communication Programs In Rhode Island, Erin R. Harrington

Open Access Dissertations

Over the past few decades, prestigious scientific institutions such as The National Science Foundation (NSF) and the National Academy of Sciences have acknowledged the utmost importance of science communication to help improve the general public’s understanding of scientific knowledge. NSF has gone so far as to make “dissemination of research findings to increase scientific literacy” the third most recommended category for research funding priorities, second only to teaching and training, and broadening participation of underrepresented groups (NSB 2011, Skrip 2015). These efforts attest to a growing interest and investment in improving the field of science communication (Druschke and McGreavy 2016); …

Analyzing The Differential News Coverage Of The North Atlantic And North Pacific Right Whales: A Case Study Of Agenda Setting, Framing, And Tone In Endangered Species Communication, Colette Soulier

Open Access Master's Theses

Mixed methods analysis was used to evaluate policy protections and media coverage of the less endangered North Atlantic Right Whale (NARW) compared to the more endangered North Pacific Right Whale (NPRW) from 2008-2020. The NARW and NPRW represent an interesting case study of mismatched conservation action and threat status, due to their highly similar appearance and membership in a traditionally highly prioritized group for conservation action. This study establishes large differences in policy creation between the species and uses media content analysis of news coverage of both whales to understand trends in framing, tone, and content between articles focusing on …

The Role Of Federalism In Initiating Offshore Wind Development In The United States And Europe, Clayton K. Starr

Open Access Master's Theses

For the United States, offshore wind represents a significant opportunity to meet renewable energy goals, contribute to climate change mitigation, and pursue economic development. Yet despite having abundant wind resources, the United States lags behind most countries with active offshore wind industries in terms of total installed capacity. Drawing on environmental federalism theory, this thesis used desk research and key informant interviews with offshore wind policy experts (n = 22) to compare the effects of federalism on offshore wind development in the United States and Europe. Interview data were coded using the program Atlas.ti, and applied thematic analysis revealed five …

Influence Of The Cpa Credential On The Life Satisfaction Of University Of Northern Iowa Accounting Alumni, Derek Richard Koppes

Honors Program Theses

This paper aims to explore the relationship between obtaining a CPA as a University of Northern Iowa accounting graduate and measures of life satisfaction. In this study, survey data were collected from a random sample of University of Northern Iowa accounting graduates. The research suggests that graduates who obtained the CPA credential have higher levels of life satisfaction. Accounting students at the University of Northern Iowa for years to come stand to benefit greatly from this research because the results of this study provide more insight into the favorable outcomes that are enjoyed by accounting alumni who elected to pursue …

An Analysis Of Thermal Comfort Perception In Cal Poly's Math & Science Building, Pouria Ali Fariborzi

Master's Theses

Since Americans, on average, spend approximately 90% of their time indoors according to the EPA, it is crucial to provide room occupants with the best, most comfortable, and healthiest possible environment, which is known as Indoor Environmental Quality (IEQ). This thesis aims to identify how we can provide comfortable learning environments to improve student success. To determine the best possible environment for occupants, a model of the Math & Science Building was developed, validated, and modified using DesignBuilder. In addition, we compared thermal comfort surveys to actual measured conditions for some classrooms. Analysis indicates that students prefer a cooler thermal …

Creating A Middle School Makerspace In An International Baccalaureate School, Brad White

Liberal Studies (MA) Final Essays

The availability of a makerspace lab is a new initiative at The Academy for Discovery at Lakewood (ADL), a Norfolk City Public School. The academy follows the International Baccalaureate Middle Years Program curriculum. This project gives background on the makerspace movement and details the steps that were taken to design and equip the lab environment, as well as provide teachers with professional development on how the lab can be used to support rigorous course curriculum. This project also includes considerations for further action, including the creation of a student survey regarding opinions on what value the makerspace lab contributes to …

Asset Managers As Regulators, Dorothy S. Lund

Faculty Scholarship

The conventional view of regulation is that it exists to constrain corporate activity that harms the public. But amid perceptions of government failure, many now call on corporations to tackle social problems themselves. And in this moment of dissatisfaction with government, powerful asset managers have stepped in to serve as regulators of last resort, adopting rules that bind corporate America on issues of great social importance, including climate change and workplace diversity. This Article describes this dynamic — where shareholders have become regulators — which has been made possible by the rise of institutional shareholding (and index investing in particular) …

Sga 54 2022 Bylaws, Niu Student Government Association Senate

Student Government Association Archives

No abstract provided.