Digital Commons Network^™

Reproductive Regrets Among A Population-Based Sample Of U.S. Women, Arthur L. Greil, Michele H. Lowry, Andrea R. Burch, Kathleen Slauson-Blevins, Nicholas Park, Julia Mcquillan

Sociology & Criminal Justice Faculty Publications

Women have many reproductive options, but little is known about their regrets regarding prior reproductive choices and outcomes. Guided by the life-course and stratified reproduction perspectives, this study draws on an open-ended question about reproductive regrets from wave I of the National Survey of Fertility Barriers, a representative telephone survey of reproductive aged U.S. women conducted from 2004 to 2006. The authors classified regrets into five broad categories: (1) none, (2) problematic fertility, (3) unfulfilled fertility desires, (4) family, and (5) pregnancy experiences. The authors conducted the analyses separately by motherhood status. Logistic regression analysis revealed that regardless of parental …

Covid-19 Vaccination In Palestine/Israel: Citizenship, Capitalism, And The Logic Of Elimination, Nicolas Howard, Emily Schneider

Sociology & Criminal Justice Faculty Publications

Despite Israel’s responsibility under international law to combat the spread of contagious diseases and epidemics in its occupied territories, Israeli officials have refused to distribute COVID-19 vaccines to Palestinians in the West Bank and Gaza Strip. Through a critical discourse analysis of Israeli officials’ statements regarding Israel’s COVID-19 vaccination campaign, this paper explores how Israel evades this responsibility while presenting itself as committed to public health and human rights. We find that Israeli officials strategically present Palestinians as an autonomous nation when discussing COVID-19 vaccinations, despite Israel’s ongoing attempts to prevent the creation of a Palestinian state. Relatedly, Israel justifies …

Induction Immunotherapy Followed By Thoracic Radiation Without Chemotherapy In Unresectable Stage Iii Non-Small Cell Lung Cancer: A Case Series., Srikiran Dasari, Takefumi Komiya Md

PCI Publications and Projects

OBJECTIVE: Although concurrent chemoradiation has been the standard of care for unresectable stage III non-small cell lung cancer (NSCLC) due to increased survival and decreased disease progression, patients with poor performance status cannot tolerate chemotherapy toxicity well. Durvalumab, an immune checkpoint inhibitor targeting the programmed death receptor-1 (PD-1) / programmed death-ligand 1 (PD-L1) axis, demonstrated efficacy as maintenance therapy after definitive chemoradiation. However, the role of immunotherapy in those who cannot tolerate chemoradiation is unclear.

METHODS: This retrospective case series reports adult patients with PD-L1-expressing stage III NSCLC diagnosed at Parkview Cancer Institute from 2019-2021 and treated initially with pembrolizumab …

This Is Not A Drill: The War Against Antiracist Teaching In America, Kimberlé W. Crenshaw

Faculty Scholarship

On January 5, 2022, Professor Kimberlé Williams Crenshaw received the 2021 Triennial Award for Lifetime Service to Legal Education and the Legal Profession from the Association of American Law Schools (AALS). In this modified acceptance speech delivered at the 2022 AALS Awards Ceremony, she reflects on the path that brought her to this moment and the crisis over antiracist and social justice education that is unfolding today. Arguing that the legal academy bears a collective responsibility to fight back against the silencing of antiracist frameworks, she calls on legal educational institutions to confront their historical agnosticism toward racial subordination and …

The Short- And Long-Term Effects On The Microbiome Of Infants Who Are Exposed To Opioids In Utero, Dawson Brown-Ezell

Undergraduate Honors Theses

Introduction: The gut microbiome is believed to have a significant impact on health throughout the lifespan, and the influence of infant nutrition and other environmental factors are of particular interest in its development. The aim of this research project was to learn more about the microbiome and short chain fatty acid (SCFA) composition of toddlers of differing weights, considering birth history, environment, and diet. In East Tennessee, opioid misuse is a growing issue, and a number of participants in this study were exposed in utero. We also hoped to identify related effects on infant’s SCFA composition. Finally, it is known …

Loss Of Mmr And Tgfbr2 Increases The Susceptibility To Microbiota-Dependent Inflammation-Associated Colon Cancer, Elena Tosti, Ana S Almeida, Tam T T Tran, Mariel Barbachan E Silva, Pilib Ó Broin, Robert Dubin, Ken Chen, Amanda P Beck, Andrew S Mclellan, Eduardo Vilar, Aaron Golden, Paul W O'Toole, Winfried Edelmann

Faculty, Staff and Student Publications

Background and aims: Mutations in DNA mismatch repair (MMR) genes are causative in Lynch syndrome and a significant proportion of sporadic colorectal cancers (CRCs). MMR-deficient (dMMR) CRCs display increased mutation rates, with mutations frequently accumulating at short repetitive DNA sequences throughout the genome (microsatellite instability). The TGFBR2 gene is one of the most frequently mutated genes in dMMR CRCs. Therefore, we generated an animal model to study how the loss of both TGFBR2 signaling impacts dMMR-driven intestinal tumorigenesis in vivo and explore the impact of the gut microbiota.

Methods: We generated VCMsh2/Tgfbr2 mice in which Msh2loxP and Tgfbr2loxP alleles are …

Recent Advances On Dna Base Flipping: A General Mechanism For Writing, Reading, And Erasing Dna Modifications, Ren Ren, John R Horton, Samuel Hong, Xiaodong Cheng

Faculty, Staff and Student Publications

The modification of DNA bases is a classic hallmark of epigenetics. Four forms of modified cytosine-5-methylcytosine, 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine-have been discovered in eukaryotic DNA. In addition to cytosine carbon-5 modifications, cytosine and adenine methylated in the exocyclic amine-N4-methylcytosine and N6-methyladenine-are other modified DNA bases discovered even earlier. Each modified base can be considered a distinct epigenetic signal with broader biological implications beyond simple chemical changes. Since 1994, several crystal structures of proteins and enzymes involved in writing, reading, and erasing modified bases have become available. Here, we present a structural synopsis of writers, readers, and erasers of the modified …

A Phase I, Open-Label, Dose-Escalation Study Of The Ox40 Agonist Ivuxolimab In Patients With Locally Advanced Or Metastatic Cancers, Adi Diab, Omid Hamid, John A Thompson, Willeke Ros, Ferry A L M Eskens, Toshihiko Doi, Siwen Hu-Lieskovan, Samuel J Klempner, Bishu Ganguly, Catherine Fleener, Xiao Wang, Tenshang Joh, Ken Liao, Shahram Salek-Ardakani, Carrie Turich Taylor, Jeffrey Chou, Anthony B El-Khoueiry

Faculty, Staff and Student Publications

PURPOSE: Stimulation of effector T cells is an appealing immunotherapeutic approach in oncology. OX40 (CD134) is a costimulatory receptor expressed on activated CD4

PATIENTS AND METHODS: Adult patients (

RESULTS: The most common all-causality adverse events were fatigue (46.2%), nausea (28.8%), and decreased appetite (25.0%). Of 31 treatment-related adverse events, 30 (96.8%) were grade ≤2. No dose-limiting toxicities occurred. Ivuxolimab exposure increased in a dose-proportionate manner from 0.3 to 10 mg/kg. Full peripheral blood target engagement occurred at ≥0.3 mg/kg. Three (5.8%) patients achieved a partial response, and disease control was achieved in 56% of patients. Increased CD4

CONCLUSIONS: Ivuxolimab …

Inhibition Of The Cd47-Sirpα Axis For Cancer Therapy: A Systematic Review And Meta-Analysis Of Emerging Clinical Data, Ji Son, Rodney Cheng-En Hsieh, Heather Y Lin, Kate J Krause, Ying Yuan, Amadeo B Biter, James Welsh, Michael A Curran, David S Hong

Faculty, Staff and Student Publications

CD47-SIRPα interaction acts as a "don't eat me" signal and is exploited by cancer to downregulate innate and adaptive immune surveillance. There has been intense interest to develop a mechanism of blockade, and we aimed to analyze the emerging data from early clinical trials. We performed a systematic review and meta-analysis of relevant databases and conference abstracts including clinical trials using CD47 and/or SIRPα inhibitors in cancer treatment. Nonlinear mixed models were applied for comparison of response and toxicity. We retrieved 317 articles, 24 of which were eligible. These included 771 response-evaluable patients with hematologic (47.1%) and solid tumors (52.9%). …

Cell-Directed Aptamer Therapeutic Targeting For Cancers Including Those Within The Central Nervous System, Jun Wei, Renduo Song, Aria Sabbagh, Anantha Marisetty, Neal Shukla, Dexing Fang, Hinda Najem, Martina Ott, James Long, Lijie Zhai, Maciej S Lesniak, Charles David James, Leonidas Platanias, Michael Curran, Amy B Heimberger

Faculty, Staff and Student Publications

Osteopontin (OPN) is produced by tumor cells as well as by myeloid cells and is enriched in the tumor microenvironment (TME) of many cancers. Given the roles of OPN in tumor progression and immune suppression, we hypothesized that targeting OPN with aptamers that have high affinity and specificity could be a promising therapeutic strategy. Bi-specific aptamers targeting ligands for cellular internalization were conjugated to siRNAs to suppress OPN were created, and therapeutic leads were selected based on target engagement and

Comparison Of Psma-Based 18f-Dcfpyl Pet/Ct And Pelvic Multiparametric Mri For Lesion Detection In The Pelvis In Patients With Prostate Cancer, Trinh T Nguyen, Priya R Bhosale, Guofan Xu, Tinsu Pan, Peng Wei, Yang Lu

Faculty, Staff and Student Publications

Purpose: To directly compare the performance of pelvic mpMRI versus recently approved and increasingly used PSMA-based 18F-DCFPyL PET/CT in intermediate-high risk and biochemical recurrent prostate cancer patient cohort while exploring their potential differing applications in specific clinical scenarios.

Methods: A retrospective analysis was performed on patients who had 18F-DCFPyL PET/CT and pelvic mpMRI done from September 2021 to January 2022 at a single institution. The inclusion criteria were paired exams within a 3-month interval. Exclusion criteria were intervening treatment between exams, a change in PSA by more than 50% and absolute difference more than 1 ng/mL, or concurrent history of …

Checkpoint Inhibitors As Immunotherapy For Fungal Infections: Promises, Challenges, And Unanswered Questions, Sebastian Wurster, Stephanie S Watowich, Dimitrios P Kontoyiannis

Faculty, Staff and Student Publications

Opportunistic fungal infections have high mortality in patients with severe immune dysfunction. Growing evidence suggests that the immune environment of invasive fungal infections and cancers share common features of immune cell exhaustion through activation of immune checkpoint pathways. This observation gave rise to several preclinical studies and clinical case reports describing blockade of the Programmed Cell Death Protein 1 and Cytotoxic T-Lymphocyte Antigen 4 immune checkpoint pathways as an adjunct immune enhancement strategy to treat opportunistic fungal infections. The first part of this review summarizes the emerging evidence for contributions of checkpoint pathways to the immunopathology of fungal sepsis, opportunistic …

An Autoencoder-Based Deep Learning Method For Genotype Imputation, Meng Song, Jonathan Greenbaum, Joseph Luttrell, Weihua Zhou, Chong Wu, Zhe Luo, Chuan Qiu, Lan Juan Zhao, Kuan-Jui Su, Qing Tian, Hui Shen, Huixiao Hong, Ping Gong, Xinghua Shi, Hong-Wen Deng, Chaoyang Zhang

Faculty, Staff and Student Publications

Genotype imputation has a wide range of applications in genome-wide association study (GWAS), including increasing the statistical power of association tests, discovering trait-associated loci in meta-analyses, and prioritizing causal variants with fine-mapping. In recent years, deep learning (DL) based methods, such as sparse convolutional denoising autoencoder (SCDA), have been developed for genotype imputation. However, it remains a challenging task to optimize the learning process in DL-based methods to achieve high imputation accuracy. To address this challenge, we have developed a convolutional autoencoder (AE) model for genotype imputation and implemented a customized training loop by modifying the training process with a …

Recurrent Hgnet-Mn1 Altered (Astroblastoma Mn1-Altered) Of The Foramen Magnum: Case Report And Molecular Classification, Sricharan Gopakumar, Malcolm F Mcdonald, Himanshu Sharma, Claudio E Tatsui, Gregory N Fuller, Ganesh Rao

Faculty, Staff and Student Publications

Background: Astroblastoma is a rare primary brain tumor of unclear origin, often occurring in young patients less than 30-years-old. It typically arises supratentorially and is diagnosed based on histological features including vascular hyalinization and perivascular pseudorosettes. Recent molecular characterization of primary CNS high-grade neuroepithelial tumors with meningioma I alteration (HGNET-MN1) found that HGNET-MN1 and tumors with morphological signatures of astroblastoma clustered together. Further analysis revealed such astroblastomas have MN1 alteration and the 2021 WHO classification of tumors of the CNS now recognizes astroblastoma MN1-altered as a new entity.

Case description: Here, we present the case of …

Body Image Mediating The Relationship Between Personality Factors, Emotionality And Extraversion, And Psychological Well-Being In A Gender-Diverse And Queer Sample, Rachel Jones

Senior Independent Study Theses

Research has examined the relationship between personality factors, body image, and psychological well-being. Some researchers look at how the three variables interact and relate to each other. Previous research shows how different levels of Emotionality and Extraversion influence one’s body image and psychological well-being (Allen & Celestino, 2018; Kokko et al., 2013; Lie et al., 2015; Swami et al., 2008). One’s body image also influences their psychological well-being. Additionally, personality factors, such as high Emotionality and low Extraversion can lead to someone having worse body image and worse well-being (Allen & Celestino, 2018). In a questionnaire that was made up …

Desperate Democrats In The Reagan Revolution: A Party Determined To Win The White House, Matthew Maxwell Akins

Senior Independent Study Theses

Bill Clinton’s 1992 election to the presidency as a Democrat ended a series of defeats for that party on the presidential level. Clinton may have won the White House, but he did not do it alone. In the decade before his victory, the “New Democrats” worked to moderate the Democratic Party from within, responding to the presidential losses of 1980, 1984, and 1988. Scholars have explored this topic from many angles, but none have explored it from the perspective of these “New Democrats” in a way that traces their story from Al From and Gillis Long to the DLC and …

Spiritual And Sexual Simultaneity: The Fourteenth-Century Psalter Of Bonne Of Luxembourg, Zoe Johnson

Senior Independent Study Theses

No abstract provided.

Stroke Clustering And Fitting In Vector Art, Khandokar Shakib

Senior Independent Study Theses

Vectorization of art involves turning free-hand drawings into vector graphics that can be further scaled and manipulated. In this paper, we explore the concept of vectorization of line drawings and study multiple approaches that attempt to achieve this in the most accurate way possible. We utilize a software called StrokeStrip to discuss the different mathematics behind the parameterization and fitting involved in the drawings.

Creating An Arcgis Dashboard For Climate Data Management And Visualization, Sydney Noel Case

Senior Independent Study Theses

The College of Wooster Department of Earth Sciences has collected over the past 12 years (and continues to collect) hourly local climate indicator data including stream level and temperature, air temperature and pressure, precipitation levels, and relative humidity. This data is collected at the College’s research station, Fern Valley, located in Holmes County, Ohio and serves as a storytelling component for regional climate change. Upon initial investigation, the extensive dataset revealed a fundamental data storage problem within Earth Sciences, as there lacked a singular location to store complex datasets. Several technological solutions were explored to create a long-term data storage, …

“What Does The Black Legend Have To Do With Cusco?”: Un Discurso De La Alteridad, La Evangelización, Y El Arte Religioso En El Cusco Colonial, Cammy Bly

Senior Independent Study Theses

Este trabajo considera las representaciones gráficas y artísticas de la conquista y la evangelización de las Américas en el contexto de la construcción del yo y del otro de Tzvetan Todorov y la reconceptualización de La Leyenda Negra de Walter Mignolo. Todorov propone que la conquista de las Américas es la conquista que “el yo hace del otro” (Todorov 13). Según Todorov, la construcción de la alteridad, u otherness, motivó las acciones de los conquistadores en las Américas y puso a los indígenas en una posición social inferior. Además de la teoría de Todorov, Walter Mignolo utiliza el …

Unearthing The Effects Of European-American Settlement On A Northeast Ohio Kettle Lake Through Diatom Stratigraphy, Justine Paul A. Berina

Senior Independent Study Theses

Recently, wetland conservation has highlighted the necessity for assessing limnological changes following European-American settlement. A prior study at Brown's Lake (northeast Ohio) identified a stratigraphic sequence that shows an abrupt transition from organic-rich muds to several centimeters of a bright loess layer, then a recovery to organic-rich sediments near the top. Based on ²¹⁰Pb dates, the loess deposition occurred before 1846 CE, when a growing population cleared trees and farmed intensively. Likewise, organics had recovered after 1950 CE, when people abandoned farmland and practiced conservation tillage. However, the effects of settlement on limnology are poorly known. Diatoms (microscopic algae; …

Backlog Burner: An Adventure Into Automated Scheduling, Anjolaoluwa J. Olubusi

Senior Independent Study Theses

The focus of this independent study is to explain the nurse scheduling problem (NSP) and use it as a basis to create an automated scheduling program. The nurse scheduling problem is an operational research problem that sets to find an optimal hospital schedule that fulfills the needs of the hospital and the personal requests of the nurses. The majority of solutions for the nurse scheduling problem are often designed within a hospital setting. The objective of this independent study is to use the solutions of the nurse scheduling problem to develop an automated scheduling program for the College of Wooster …

Puffins, The Charismatic Clowns Of The Sea: Examining The Relationship Between Community Identity And The Social Construction Of Animals, Megan Henry Tuennerman

Senior Independent Study Theses

This study analyzes the factors, internal and external, that affect the relationship between community identity and the social construction of animals, and the ways in which that social construction impacts the environment. Studied through the lens of the relationship between Atlantic Puffins and the human communities they live near, these questions situate our understanding of human societies as within, as opposed to above, the environment. Without this perspective, enacting environmental protections across the globe is ineffective. The study was conducted using ethnographic methods, including 11 formal interviews with community members and experts, along with observations in Iceland and Canada. Results …

Integrating Art History Into K-5 Social Studies Classrooms, Kate L. Schlegel

Senior Independent Study Theses

This independent study investigates the possibility for interaction between art and history in elementary school curriculum. An analysis of current education initiatives at the federal level establishes the need to create a more effective history—or, its counterpart at the elementary level, social studies--curriculum. Since other subjects–such as English, math, and science–are assessed at the national level, while history is not, this subject is often under-emphasized in order to meet learning targets in these other subjects. A study of educational theorists, such as Piaget and William Blake, establishes the potential for the study of history with students at lower stages of …

Sheltered: An Investigation Of Homelessness In The United States, Maya Renee Vasta

Senior Independent Study Theses

The purpose of this project is to investigate the connection between the social and statistical findings regarding the issue of homelessness in the United States. Because of the inconsistencies with how homelessness is tracked, two government-provided sources were used. The United States Interagency Council on Homelessness provides general data of homelessness, while the U.S. Department of Housing and Urban Development data shows the reported usage of homeless by the programs themselves. In addition, I also investigate the social impact and experiences of this issue to provide a more dynamic view of the problem of homelessness in the states. It was …

Visual Looming Cues Increases The Auditory Looming Bias, Maggie K. Mccracken

Senior Independent Study Theses

Looming objects have been environmentally relevant cues throughout human evolution due to potential danger. Observers integrate both auditory and visual signals emitted by moving objects. While visual arrival time estimates are relatively more accurate, auditory estimates are anticipatory as observers perceive a moving sound source as arriving before it actually does. In the present study, participants made loudness change judgments of sounds presented unimodally or with visual motion. The sounds consisted of two intensity ranges and conditions included both looming and receding motion. The results showed that listeners perceived looming sounds as changing more in loudness than equivalent receding sounds. …

Still Awaiting Justice: An Analysis On The Impact Of Anti-Immigrant Sentiment On The Reproductive Autonomy Of Migrant Women, Annays Esperanza Yacaman

Senior Independent Study Theses

My research aims to explain the impact of anti-immigrant sentiment on the reproductive autonomy of migrant women. Legislators typically act as their constituents feel on a certain issue, so I aimed to explore how legislators responded with legislation when their constituents held higher levels of anti-immigrant sentiment, hypothesizing that this would lead to more legislation limiting the reproductive autonomy of migrant women. I explore topics of eugenics and how anti-immigrant sentiment has led to modern day eugenics.

My hypothesis did not manifest itself in the expected way, but the results do provide evidence for a causal link between legislation meant …

"Not Liberating Women Means The Building Of A Socialist Society Is Only Half-Way Done": A Feminist Analysis Of Ho Chi Minh's Advocacy For The First Law On Marriage And Family In 1959 Vietnam, Hannah Nguyen

Senior Independent Study Theses

In October 1959, Ho Chi Minh attended and spoke before the North Vietnamese National Assembly at the “Meeting to Discuss the Draft of the Law on Marriage and Family.” The purpose of this study is to provide a feminist rhetorical analysis of this address to explicate the rhetorical strategies Ho employed to advocate for this law. I argue that Ho reframed the Marriage and Family Law into a policy that corresponded to the needs and demands of the National Assembly through methods of dissociation, association, and strategic repetition. I also found that Ho employed a dual leader/uncle first persona to …

Gaming The System: A Game Theoretic Approach To Risk Management And Cybersecurity, Abigail Breitenbucher

Senior Independent Study Theses

In this independent study, we detail two fields of game theory, traditional and evolutionary. After establishing foundational concepts in both, we explore risk management and cybersecurity through a game theoretic lens, focusing on some current applications in both fields. The research culminates in an application case of a game theoretic model for the 2017 Equifax data breach. To conclude, we discuss the implications of this model and future work involving evolutionary game theory in cybersecurity/risk management.

Setting The Stage For Representation: Women Candidates And Moderators' Impact On The Prevalence Of Women's Issues In Presidential Primary Debates, Hannah Groetsch

Senior Independent Study Theses

This Independent Study explores how women’s increased presence in presidential primary debates impacts the extent to which women’s issues are discussed in the debates. Prior research on political representation and critical mass theory indicates that women politicians can turn their identity as women (descriptive representation) into action that benefits their women constituents (substantive representation) by adding women’s voices and lived experiences into the political conversation. I capitalize on the 2020 election being the first where multiple women presidential candidates ran against each other, allowing me to see whether the increase in the number of women participating in the Democratic primary …