Digital Commons Network^™

Distinguishing Tumor Admixed In A Radiation Necrosis (Rn) Background: 1h And 2h Mr With A Novel Mouse Brain-Tumor/Rn Model, Xia Ge, Kyu-Ho Song, John A Engelbach, Liya Yuan, Feng Gao, Sonika Dahiya, Keith M Rich, Joseph J H Ackerman, Joel R Garbow

2020-Current year OA Pubs

PURPOSE: Distinguishing radiation necrosis (RN) from recurrent tumor remains a vexing clinical problem with important health-care consequences for neuro-oncology patients. Here, mouse models of pure tumor, pure RN, and admixed RN/tumor are employed to evaluate hydrogen (

MATERIALS AND METHODS: A pipeline of common quantitative

RESULTS: Differences in quantitative

CONCLUSIONS: These findings, employing a pipeline of quantitative

The Temporal Relationship Between Local School Closure And Increased Incidence Of Pediatric Diabetic Ketoacidosis, Casey K Mccluskey, Janine E Zee-Cheng, Margaret J Klein, Matthew C Scanlon, Alexandre T Rotta, Kenneth E Remy, Christopher L Carroll, Steven L Shein

2020-Current year OA Pubs

IMPORTANCE: The incidence of pediatric diabetic ketoacidosis (DKA) increased early in the COVID-19 pandemic, but the relative contribution of behavioral changes and viral-related pathophysiology are unknown.

OBJECTIVE: To evaluate the relationship between school closure date and onset of increased DKA to help clarify the etiology of the increased incidence.

DESIGN: A multi-center, quality-controlled Pediatric Intensive Care Unit (PICU) database was used to identify the number of admissions to a participating PICU with DKA on each calendar day from 60 days before local school closure to 90 days after, and compared to baseline data from the same periods in 2018-2019. Interrupted …

Children With Supratentorial Midline Pilocytic Astrocytomas Exhibit Multiple Progressions And Acquisition Of Neurologic Deficits Over Time, Nicole M Brossier, Jennifer M Strahle, Samuel J Cler, Michael Wallendorf, David H Gutmann

2020-Current year OA Pubs

No abstract provided.

Gain And Loss Of Task3 Channel Function And Its Regulation By Novel Variation Cause Kcnk9 Imprinting Syndrome, Margot A. Cousin, Marwan Shinawi, Et Al.

2020-Current year OA Pubs

No abstract provided.

Fully Probabilistic Reliability And Resilience Analysis Of Coastal Structures Based On Damage Evolution Simulation, D Malliouri, N Martzikos, V Tsoukala

School of Biological and Marine Sciences

An integrated methodology is presented to ensure coastal structures’ resilience to extreme wave conditions i.e. their ability to withstand further wave actions without reaching their ultimate limit state. Specifically, a fully probabilistic reliability analysis of a rubble mound breakwater is performed here, in combination with a prediction analysis of the expected time of the structure’s maintenance. The methodology combines information on the joint probability density function of significant wave height, spectral peak wave period, and storms’ duration and calculates the probability of occurrence of different levels of damage in the structure’s lifetime via the use of a fully probabilistic reliability …

Regulation Of Gene Expression During Ontogeny Of Physiological Function In The Brackishwater Amphipod Gammarus Chevreuxi, C. Mcandry, M. Collins, O. Tills, J. I. Spicer, M. Truebano

School of Biological and Marine Sciences

No abstract provided.

A Map Of Neurofilament Light Chain Species In Brain And Cerebrospinal Fluid And Alterations In Alzheimer's Disease, Melissa M Budelier, Yingxin He, Nicolas R Barthelemy, Hong Jiang, Yan Li, Ethan Park, Rachel L Henson, Suzanne E Schindler, David M Holtzman, Randall J Bateman

2020-Current year OA Pubs

Neurofilament light is a well-established marker of both acute and chronic neuronal damage and is increased in multiple neurodegenerative diseases. However, the protein is not well characterized in brain tissue or body fluids, and it is unknown what neurofilament light species are detected by commercial assays and whether additional species exist. We developed an immunoprecipitation-mass spectrometry assay using custom antibodies targeting various neurofilament light domains, including antibodies targeting Coil 1A/1B of the rod domain (HJ30.13), Coil 2B of the rod domain (HJ30.4) and the tail region (HJ30.11). We utilized our assay to characterize neurofilament light in brain tissue and CSF …

Differentiating Amyloid Beta Spread In Autosomal Dominant And Sporadic Alzheimer's Disease, Elizabeth Levitis, Jacob W Vogel, Thomas Funck, Vladimir Hachinski, Serge Gauthier, Jonathan Vöglein, Johannes Levin, Brian A Gordon, Tammie Benzinger, Yasser Iturria-Medina, Alan C Evans, Dominantly Inherited Alzheimer Network, Alzheimer’S Disease Neuroimaging Initiative

2020-Current year OA Pubs

Amyloid-beta deposition is one of the hallmark pathologies in both sporadic Alzheimer's disease and autosomal-dominant Alzheimer's disease, the latter of which is caused by mutations in genes involved in amyloid-beta processing. Despite amyloid-beta deposition being a centrepiece to both sporadic Alzheimer's disease and autosomal-dominant Alzheimer's disease, some differences between these Alzheimer's disease subtypes have been observed with respect to the spatial pattern of amyloid-beta. Previous work has shown that the spatial pattern of amyloid-beta in individuals spanning the sporadic Alzheimer's disease spectrum can be reproduced with high accuracy using an epidemic spreading model which simulates the diffusion of amyloid-beta across …

Geophagy And Microplastic Ingestion, Hoda Amiri, Mohammad Hoseini, Sajjad Abbasi, Mohammad Malakootian, Majid Hashemi, Neamatollah Jaafarzadeh, Andrew Turner

School of Geography, Earth and Environmental Sciences

No abstract provided.

Mesoscale Eddies And The Impact Of Coastal Iron Supply On Primary Production In The South Pacific Subtropical Front, Stephen M. Chiswell, Philip W. Boyd, Sylvia G. Sander, Michael J. Ellwood, Angela Milne

School of Geography, Earth and Environmental Sciences

No abstract provided.

Impact Of Fast-Track Regulatory Designations On Strategic Commercialization Decisions For Autologous Cell Therapies, Ching Lam, Edward Meinert, Aidong Yang, Zhanfeng Cui

School of Nursing and Midwifery

Background: Regulatory authorities around the world have introduced incentives to improve the speed-to-market of innovative therapies. Aim & methods: To better understand the capacity and portfolio planning decisions of autologous cell therapies and particularly the impact of fast-tracking designations, this paper describes a mixed-integer linear programming approach for the optimization of capacity investment and portfolio selection decisions to maximize the net present value of a candidate portfolio of therapies under different regulatory programs. Results: The illustrative example shows that fast-track designations allow a 25% earlier breakeven, 42–86% higher net present value over a 20-year horizon with earlier upfront capital and …

'Mercy, Tenderness, And Compassion': A Study Into The Inclusion Of Acts Of Communal And Familial Support Within Seventeenth-Century Quaker Records Of Sufferings, Toni Wadman

School of Law, Humanities and Social Sciences Theses

This thesis explores the inclusion of encounters of communal and familial compassion and support within seventeenth century Quaker records of sufferings. Whilst previous academic works have used these accounts of communal support to highlight the social integration of Friends within their local communities, little focus has been placed upon the purpose or reasoning behind their presence within Quaker suffering records. This thesis, therefore, examines how Friends perceived and understood these encounters as well as the reasoning and motivation behind their inclusion in their accounts of sufferings. To help answer these questions, this project consults the Original Records of Sufferings, handwritten …

Painting, Playing, Personas: Inserting Change In An Established Painting Practice, Robyn Jean Thomas

School of Law, Humanities and Social Sciences Theses

This doctoral research project explores the impact and changes alternative identities —personas— and a play-based method have on my established painting practice while disentangling it from the belief that a single identity authentically makes a painting art. Its methodology provides a path to answering how using personas with 'play' within a painting practice form strategies meeting this project's aims. Three personas were created and applied across the first two stages of the studio inquiry using my painting practice's methods, including reiteration. In the third stage, continuing to paint independent of the personas, their impact and that of the infinite play …

Rethinking Liveness: An Exploration Of Phenomenological Liveness, Documentation, And Audience, Samantha Sully

School of Law, Humanities and Social Sciences Theses

This paper explores experiential liveness discourse through the lens of phenomenology, semiotics, and auto-ethnographical research. This thesis examined previous experiential liveness studies and discourses and how these ideologies build a discourse centred around audience/performer relationships, communitas and virtual communities. It explores the interactions between experiential and ontological liveness through documentation, digital archiving and Descartesian dualism. Further, this thesis re-frames core ontological terms within the phenomenological liveness context. It examines event and ritual as experiences and explores my experiences of liveness with reference to previous experiential liveness studies. Finally, this paper examines the importance of experiential liveness as its own discourse …

Development And Validation Of The Short Version Of The Sense Of Humor Scale (Shs-S), Sonja Heintz, Willibald Ruch, Chloe Lau, Donald H. Saklofske, Paul Mcghee

School of Psychology

Abstract. Humor training has become increasingly popular to enhance the “sense of humor” and well-being and to decrease depressive symptoms. Despite the wide applications of these training programs, the assessment of training efficacy has attracted less attention. The Sense of Humor Scale (SHS; McGhee, 1996 , 1999 ) recently was expanded to a long version (SHS-L) to enhance its internal consistency ( Ruch & Heintz, 2018 ). At the same time, there is also the need for a brief version of this scale. The purpose of the present study is to develop a short version (SHS-S) in both German- and …

Book Review: The Guitar: Tracing The Grain Back To The Tree, P Simpson

School of Geography, Earth and Environmental Sciences

No abstract provided.

Atomic Spectrometry Update: Review Of Advances In Elemental Speciation, Robert Clough, Chris F. Harrington, Steve J. Hill, Yolanda Madrid, Julian F. Tyson

School of Geography, Earth and Environmental Sciences

This review covers advances in elemental speciation by a range of coupled techniques, including HPLC-ICP-MS, HPLC-HG-AFS and GC-ICP-MS.

A Meeting Of Positive Behaviors: The Relations Of Three Aspects Of Flexibility With Character Strengths., Valentina Vylobkova, Sonja Heintz

School of Psychology

INTRODUCTION: The adaptation of own plans and behaviors to new circumstances seems to be a desirable personal quality in the modern world. it has been assumed that adaptability cannot be transferred to a single character strength. METHODS: The present research examines this assumption using typical and daily behaviors of three aspects of flexibility (predictability, adaptability and orderliness) and 24 character strengths across two studies (N1 = 283, N2 = 188). RESULTS: Flexibility showed a consistent and large overlap with character strengths. Adaptability was positively related to most of the strengths. Predictability was positively related to humility and prudence, and orderliness …

Labouring Together: Women's Experiences Of “Getting The Care That I Want And Need” In Maternity Care, Vanessa Watkins, Cate Nagle, Bridie Kent, Maryann Street, Alison M. Hutchinson

School of Nursing and Midwifery

Poor interprofessional collaboration and lack of decision-making with women have been identified as being detrimental to the quality, safety, and experience of maternity care. The aim of the Labouring Together study was to explore childbearing women's preferences for and experiences of collaboration and control over decision-making in maternity care. Design A sequential, mixed-method, multi-site case study approach was used to explore the perceptions and experiences of childbearing women regarding collaboration and decision-making. Women's preferred role for decision-making compared to the actual experiences, and the influences upon their preferences and experiences of collaboration were explored using semi-structured interviews. An inductive approach …

Systematic Review Of Copper Intrauterine Contraception Continuation In Young Nulliparous Women Based On Intrauterine Device Type, H Akintomide, A James, M Moffat, P Barnes, J Rankin

School of Nursing and Midwifery

ObjectivesNo copper intrauterine device (IUD) type is known to better suit young nulliparous women who tend to experience higher rates of IUD discontinuation compared with their older parous counterparts. A systematic review to determine which IUDs have higher continuation rates in young nulliparous women was undertaken.DesignSystematic review and meta-analyses of available evidence based on IUD type.Data sourcesAMED, BNI, CINAHL, DARE, EMBASE, EMCARE, HMIC, MEDLINE, PsycINFO, PubMed, TRIP, and the Cochrane Library electronic databases were searched from inception to 11 May 2022; as well as the Bandolier, Medicines and Healthcare products Regulatory Agency, Faculty of Sexual and Reproductive Healthcare, Royal College …

Synchronized Seed Germination And Seedling Growth Of Black Cumin, Mohammed Elsayed El-Mahrouk, Mossad Khairy Maamoun, Yaser Hassan Dewir, Antar Nasr El-Banna, Hail Z. Rihan, Ahmed Salamh, Ahmed A. Al-Aizari, Michael P. Fuller

School of Biological and Marine Sciences

Black cumin (Nigella sativa) is an important medicinal plant in the pharmacological industry. It is cultivated on a commercial scale, but its seeds have a slow, unsynchronized germination rate. Enhancing seed germination is crucial for improving the production of black cumin. The influence of presowing treatments [gibberellic acid (GA3), potassium nitrate, salicylic acid, and stratification at 4 °C] on seed germination was assessed. Seed germination was determined daily for 30 days, and germination parameters, including final germination percentage (FGP), corrected germination rate, number of days to reach 50% of FGP, and seedling length vigor index, were evaluated. Endogenous contents of …

Consequences Of Thermal Plasticity For Hypoxic Performance In Coastal Amphipods, Michael Collins, Manuela Truebano, John I. Spicer

School of Biological and Marine Sciences

No abstract provided.

Life In The Freezer: Protein Metabolism In Antarctic Fish, Keiron P.P. Fraser, Lloyd S. Peck, Melody S. Clark, Andrew Clarke, Simeon L. Hill

School of Biological and Marine Sciences

Whole-animal, in vivo protein metabolism rates have been reported in temperate and tropical, but not Antarctic fish. Growth in Antarctic species is generally slower than lower latitude species. Protein metabolism data for Antarctic invertebrates show low rates of protein synthesis and unusually high rates of protein degradation. Additionally, in Antarctic fish, increasing evidence suggests a lower frequency of successful folding of nascent proteins and reduced protein stability. This study reports the first whole-animal protein metabolism data for an Antarctic fish. Groups of Antarctic, Harpagifer antarcticus, and temperate, Lipophrys pholis, fish were acclimatized to a range of overlapping water temperatures and …

The Angle Of Attack: Rapping Technique Predicts Skill In Hermit Crab Contests, Sarah M. Lane, Tomas O. Cornwell, Mark Briffa

School of Biological and Marine Sciences

No abstract provided.

Fast And Accurate Mapping Of Fine Scale Abundance Of A Vme In The Deep Sea With Computer Vision, Nils Piechaud, Kerry L. Howell

School of Biological and Marine Sciences

No abstract provided.

Breaking’ The Magician’S Code: The Problem With Exposure Rules, Gustav Kuhn

School of Psychology

As the director of the MAGIC Lab, at Goldsmiths University of London, I oversee projects that combine psychological research methods with performance magic.For instance, we study misdirection and forcing tolearn more about consciousness and free will. We alsoseek to apply many of these principles to non-magicalcontexts. For example, we are currently exploring waysof implementing forcing principles in computergames, and we are even ‘teaching’ artificial agentsmagic deception, as part of a project to develop newcyber security technologies. By mixing magic trickswith science, we aim to uncover the secrets of the human mind (see Experiencing the Impossible [1]).

A Prospective Cohort Study Of The Impact Of Outpatient Intensive Cardiac Rehabilitation On Depression And Cardiac Self-Efficacy, Kristin M Mckenzie, Lauren K Park, Eric J Lenze, Kristin Montgomery, Serene Rashdi, Elena Deych, Natalie A Stranczek, Erin J Mckenzie, Michael W Rich, Valene Garr Barry, Nidhi Talpade, Tessa Carson, Linda R Peterson, Susan B Racette, Lisa De Las Fuentes, Et Al.

2020-Current year OA Pubs

STUDY OBJECTIVE: To evaluate whether an Intensive Cardiac Rehabilitation (ICR) program improves depression and cardiac self-efficacy among patients with a qualifying cardiac diagnosis.

DESIGN: Prospective, longitudinal cohort design.

SETTING: Single-center, tertiary referral, outpatient cardiac rehabilitation center.

PARTICIPANTS: Patients with a qualifying diagnosis for ICR.

INTERVENTIONS: Outpatient ICR.

MAIN OUTCOME MEASURES: Mental health, as assessed using the Patient Health Questionnaire-9 (PHQ-9) and cardiac self-efficacy using the Cardiac Self-Efficacy (CSE) scale.

RESULTS: Of the 268 patients included (median age 69 y, 73% men), 70% had no depressive symptoms at baseline (PHQ-9 score <5). PHQ-9 scores improved in the overall sample (p < 0.0001), with greater improvements among patients with mild depressive symptoms at baseline (-4 points, p < 0.001) and those with moderate to severe depressive symptoms at baseline (-5.5 points, p < 0.001). Cardiac self-efficacy improved overall, and the two subsections of the cardiac self-efficacy questionnaire titled, "maintain function" and "control symptoms" improved (all p < 0.001).

CONCLUSIONS: Participation in an outpatient ICR program is associated with …

Evaluating The Implementation Of A Multi-Level Mhealth Study To Improve Hydroxyurea Utilization In Sickle Cell Disease, J S Hankins, A A King, A A Baumann, L M. Klesges, Et Al.

2020-Current year OA Pubs

BACKGROUND: Sickle Cell Disease (SCD) is a progressive genetic disease that causes organ damage and reduces longevity. Hydroxyurea is an underutilized evidence-based medication that reduces complications and improves survival in SCD. In a multi-site clinical trial, part of the NIH-funded Sickle Cell Disease Implementation Consortium (SCDIC), we evaluate the implementation of a multi-level and multi-component mobile health (mHealth) patient and provider intervention to target the determinants and context of low hydroxyurea use. Given the complexity of the intervention and contextual variability in its implementation, we combined different behavioral and implementation theories, models, and frameworks to facilitate the evaluation of the …

Fea Modelling And Environmental Assessment Of A Thin-Walled Composite Drive Shaft, Joseph Searle, Maozhou Meng, John Summerscales

School of Engineering, Computing and Mathematics

Fibre reinforced plastics (FRP) composites have been widely used in the automotive industry with the primary focus on reduced mass. However, there are relatively few reports on their application on power transmission components, such as drive shafts. This paper explores the feasibility of replacing the traditional structural steel by light weight FRP composites in a drive shaft. Three FRP composites are considered against a steel drive shaft; basalt/epoxy, carbon/epoxy, and CNT (carbon nanotubes) reinforced carbon/epoxy composites. The mechanical performance was analysed by finite element analysis (FEA) tool and classical laminate theory (CLT), while the environmental performance was evaluated by life …

Ocean Shelf Exchange, Nw European Shelf Seas: Measurements, Estimates And Comparisons, John Huthnance, Jo Hopkins, Bee Berx, Andy Dale, Jason Holt, Philip Hosegood, Mark Inall, Sam Jones, Benjamin R. Loveday, Peter I. Miller, Jeff Polton, Marie Porter, C Springys

School of Biological and Marine Sciences

Transports across the continental shelf edge enhance shelf-sea production, remove atmospheric carbon and imply an active boundary to ocean circulation. We estimate relatively large overall transport across three contrasted sectors of north-west European shelf edge: the Celtic Sea south-west of Britain, the Malin-Hebrides shelf west of Scotland, the West Shetland shelf north of Scotland. The estimates derive from measurements in the project FASTNEt (Fluxes across sloping topography of the North East Atlantic): drifters, moored current meters, effective “diffusivity” from drifter dispersion and salinity surveys, other estimates of velocity variance contributing to exchange. Process contributions include transport by along-slope flow, internal …