Digital Commons Network^™

Exosomal Mirnas As Biomarkers For Radiation Toxicity In Breast Cancer Patients, Mina V. Mcginn

Theses and Dissertations

Radiotherapy (RT) is a standard treatment for most breast cancer patients (BCPs), but is often accompanied by acute and late toxic effects in normal tissue. Exosomes are nano vesicles about 30-150nm in size that originate from the endosomal network and are found in most body fluids. Exosomes are a fundamental driver of intercellular communication by transferring proteins, lipids and microRNA (miRNA). Exosomal miRNA (Exo-miRNA) signatures may serve as non-invasive prediction biomarkers of post-radiation toxicities of BCPs. Eighty six BCPs treated in the Radiation Oncology Department were enrolled in an IRB approved study. BCPs were evaluated weekly during RT and at …

Secondary English Teachers’ Experiences Of Agency: Connections To Shifting Educational Contexts During Covid-19, Kristina Lee

Theses and Dissertations

The COVID-19 pandemic caused schools around the world to enter uncharted territory. Due to the unprecedented nature of the educational crisis, it was important to examine how teacher agency may have been affected. Teacher agency can have important implications for school climate, policy, and the experience of stakeholders. The main focus of this study was to cultivate an understanding of secondary English teachers’ perceptions of agency as they navigated teaching throughout the COVID-19 pandemic. An ecological framework was used to examine teachers’ experiences of agency in the context of COVID-19. The study utilized a basic qualitative design with in-depth interviews …

“There Was Some Sort Of Missing Middle”: Lived Experiences Of Jewish Youth With Intellectual And Developmental Disabilities, Aliza Lambert

Theses and Dissertations

Though religion and spirituality contribute to overall well-being (Koenig, 2012; Koenig & Cohen, 2002), social support (Biggs & Carter, 2016; Koenig & Cohen, 2002; Taub & Werner, 2016), quality of life (QOL; Myers & Sweeney, 2000), coping strategies (Krok, 2008), and lower rates of depression and anxiety (Brown et al., 2013; Young et al., 2000), religion and spirituality are seldom included in curriculum in counselor education and supervision doctoral programs (Adams et al., 2015; Henriksen et al., 2015). In the present study, the researcher uses a multiple-case study design to describe the lived experiences of Jewish youth with intellectual and …

Low Insertion-Loss Nanophotonic Modulators Through Epsilon-Near-Zero Material-Based Plasmon-Assisted Approach For Integrated Photonics, Mohammad Ariful Hoque Sojib

Theses and Dissertations

Electro-optic/absorption Modulators (EOM/EAMs) encode high-frequency electrical signals into optical signals. With the requirement of large packing density, device miniaturization is possible by confining light in a sub-wavelength dimension by utilizing the plasmonic phenomenon. In plasmon, energy gets transferred from light to the form of oscillation of free electrons on a surface of a metal at an interface between the metal and a dielectric. Plasmonic provides increased light-matter interaction (LMI) and thus making the light more sensitive to local refractive index change. Plasmonic-based integrated nanophotonic modulators, despite their promising features, have one key limiting factor of large Insertion Loss (IL) which …

Perceived Discrimination And Mental Health Outcomes In College Students: The Mediating Role Of Preventive Health Behaviors And Social Support, Sarah C M Morton

Theses and Dissertations

Perceived discrimination has been linked to adverse mental health outcomes, increased risk-taking behaviors, and poor engagement in health promoting behaviors. College students may be especially susceptible to negative mental health outcomes associated with discrimination due to the unique stressors faced by young adults (e.g., prolonged transition to adulthood, onset of mental health disorders, changes in social support). The current study examined the mediating and moderating roles of health behaviors and social support on the association between perceived discrimination and mental health outcomes (e.g., anxiety, depression, suicidality) in college students. A total of 709 college students (42.8% White; 72.2% female; 30.2% …

Special Education Teacher Retention: The Importance Of Teacher Working Conditions, Erica Ross

Theses and Dissertations

Teacher retention, or why teachers stay, is an important area of study considering the impact teacher attrition and turnover can have on student outcomes (Hirsch & Emerick, 2006). Teacher attrition and turnover are even more concerning for those that are special education teachers (SETs), and it is noted as a priority to address in the state of Virginia (Solenson et al., 2018). Through an adapted organizational theory lens, this study addresses the following aims: 1) Determine if there are differences in perceptions of teacher working conditions (TWCs) between special education teachers (SETs) and teachers of other content areas and 2) …

A Technology-Based, Mixed Methods Approach To Examining The Psychosocial Determinants Of Maternal Health Disparities, Hannah M. Ming

Theses and Dissertations

Background: Exposure to racism and discrimination in the U.S. increases Black women’s risk for experiencing maternal health disparities. Additionally, racism and discrimination affect maternal psychosocial well-being, creating evidence for a biopsychosocial relationship between racism and maternal health outcomes. However, current research does not define the psychosocial Black maternal self well. Given the dynamic relationship between racism, psychosocial well-being, and Black maternal health outcomes, research must comprehensively examine the Black maternal self. The operationalization of a comprehensive construct for Black maternal psychosocial well-being can improve understanding of the relationship between racism, psychosocial well-being, and Black maternal health outcomes.

Purpose: …

Anthracyclines Attenuate The Nrf1-Mediated Bounce-Back Response, Bader Albalawi

Theses and Dissertations

Proteasome inhibitors, such as carfilzomib, are FDA-approved to treat multiple myeloma and mantle cell lymphoma. Unfortunately, proteasome inhibitors have only produced clinically significant results in patients with hematologic cancers, despite their predicted pan-cancer utility, and even hematologic cancer types frequently show intrinsic and acquired resistance.

One proposed mechanism responsible for the proteasome inhibitors' shortcomings is the NRF1-mediated bounce-back response. Identification of drugs that can potentiate the action of proteasome inhibitors could overcome resistance in patients with hematologic cancers and expand proteasome inhibitors' use to treat solid tumors. Our previous studies have identified anthracyclines as potential compounds that interfere with the …

Examining The Relationship Between Local Governmental Performance In Public Safety And The Growth In Population, Employment, And Per Capita Income For Valley Cities In Arizona, Xin Zhao

Theses and Dissertations

This study focuses on the impact of city performance in public safety on a city’s growth in population, employment, and per capita income. The effectiveness of performance management affects the willingness of governmental agencies to continue using performance management as a tool for day-to-day operations and the improvement of governmental services. The research goal of the study is to discover the relationship between city performance in public safety and the growth of a locality in population, employment, and per capita income. The purpose of the study is to determine if there is a relationship between city performance in public safety …

Caregiver's Nicu Experiences And Its Impact On Services, Crystal L. Hence

Theses and Dissertations

Having a child spend time in the Neonatal Intensive Care Unit is documented as a stressful experience for caregivers. Previous literature documents caregivers’ difficulties navigating the Neonatal Intensive Care Unit, showing that this problem has persisted for close to 20 years. Early Intervention can provide benefits to infants born prematurely, who may be more at risk for developmental delays and since the goal of Early Intervention is to provide services that help families in their daily lives, it has benefits for caregivers as well. Yet, Early Intervention enrollment remains low across the state of Virginia. This study using a qualitative …

Tummy Time In Infancy: Real-World Assessments And Associations With Developmental Outcomes In Early Childhood, Ketaki Inamdar

Theses and Dissertations

Tummy time or awake, supervised, prone play is an important developmental play position in infancy. Engaging in more than 15 minutes of tummy time per day is associated with a lower risk of plagiocephaly, lower body mass index, and achievement of higher motor scores in full-term and at-risk preterm infants. However, there are significant gaps in the measurement of tummy time in current literature. Conventionally used subjective parent reports have not been validated against gold standard direct observation, and the feasibility and real-world validity of objective solutions such as wearable sensors has not been examined in full-term and at-risk preterm …

Authenticity, Care, And Relationships: Ethical Decision-Making In Criminal Justice Education, Robert B. Lehmann

Theses and Dissertations

Many events in recent history have demonstrated the need for addressing the training of law enforcement and other public servants commonly referred to as criminal justice professionals in the United States. Reckoning with the imperfect history of the criminal justice system, specifically the history of problematic relations with marginalized people, and developing a system that is better equipped to meet the needs of an equitable and just society is at the forefront of many discussions of criminal justice reform. Improving ethical decision-making training in criminal justice education is one avenue to addressing these needs for current and future professionals. Conceptually, …

Mending Art Classrooms: An Exploration Of The Benefits Of Collaborative Artmaking For Underinvested Black Youth In Richmond, Virginia, Jazmine M. Beatty

Theses and Dissertations

This arts-informed research study explored the experiences of local community artists and educators working to radically transform and heal the experiences of underinvested Black students in Richmond through collaborative arts engagement. Through a series of seven one-on-one interviews with Black teaching artists in the Richmond community, I was able to uncover how collaboration has and can continue to improve the well-being and livelihoods of Black students in Richmond. Also, by tapping into the local Mending Walls mural project, I was able to make a tangible connection between the Richmond community, art, and collaboration. An analysis of the interviews led to …

Targeting Bcl-2 Family Proteins In Therapy Induced Senescent Cancer Cell Models, Wade Cook

Theses and Dissertations

Non-small Cell Lung Cancer (NSCLC) originates from numerous different cell types in the lungs and is among the deadliest of cancers. Head and Neck Squamous Cell Carcinomas (HNSCC) are derived from the mucosal membranes of the oral cavity, pharynx, and larynx. Both NSCLC and HNSCC are predominately caused by tobacco smoke inhalation and as such mutations in the tumor suppressor gene TP53 are common. Since similarities exist in the root cause of NSCLC and HNSCC, they may also share similarities in treatment methods. Cisplatin is a platinum-based DNA damaging agent that has been used as a cancer chemotherapy for decades. …

Sleepiness: Clinical Correlates, Association With Performance, And Effects Of Performance Feedback, Spencer Nielson

Theses and Dissertations

Background: Daytime sleepiness is a common and debilitating phenomenon. Sleepiness is associated with increased symptoms of insomnia, depression, anxiety, and fatigue. Daytime sleepiness is commonly associated with cognitive performance, including performance on the Psychomotor Vigilance Test (PVT). The PVT includes performance feedback, and that feedback may influence an individual’s report of their sleepiness. Whether the feedback on the PVT influences an individual's self-reported sleepiness is unknown. This study sought to investigate how sleepiness was associated with clinical symptoms and performance, whether there are sex differences in sleepiness, and whether manipulating feedback on the PVT influenced an individual’s self-reported sleepiness. …

Learning Robot Motion From Creative Human Demonstration, Charles C. Dietzel

Theses and Dissertations

This thesis presents a learning from demonstration framework that enables a robot to learn and perform creative motions from human demonstrations in real-time. In order to satisfy all of the functional requirements for the framework, the developed technique is comprised of two modular components, which integrate together to provide the desired functionality. The first component, called Dancing from Demonstration (DfD), is a kinesthetic learning from demonstration technique. This technique is capable of playing back newly learned motions in real-time, as well as combining multiple learned motions together in a configurable way, either to reduce trajectory error or to generate entirely …

Effects Of A Video Based Intervention On Job Interview Skills Of Youth With Autism, Kelsey T. Dunn

Theses and Dissertations

In this dissertation, I conducted a multiple-probe-across-participants design to examine the impact of a video-based intervention on interview skills of youth with autism. First, I conducted a systematic literature review of interview interventions. Results were used to guide the development of this study’s measure and procedures. Finding that previous literature relied on rubric measures to rate interview skill behaviors, I developed and piloted a primary measure for examining direct speech production. Using transcripts and video analysis, this study captures the construct of interview skills using both quantity (frequency of relevant/irrelevant c-units) and quality (interview skills rubric score). The intervention consisted …

Understanding Structure/Process-Property Relationships To Optimize Development Lifecycle In Yttria-Stabilized Zirconia Aerogels For Thermal Management, Rebecca C. Walker

Theses and Dissertations

Aerogels are mesoporous materials with unique properties, including high specific surface area, high porosity, low thermal conductivity, and low density, increasing these materials’ effectiveness in applications such as catalyst supports, sorption media, and electrodes in solid oxide fuel cells. Zirconia (ZrO₂) aerogels have special interest for high-temperature applications due to the high melting point of ZrO₂ (2715°C) and stability between 600°C and 1000°C, where other aerogel systems often begin to sinter and densify. These properties and unique pore structure make zirconia aerogels advantageous as thermal management systems, especially in aeronautics and aerospace applications. However, to be effective …

Evaluating Population Genetic Structure And Potential Genomic Signals Of Natural Selection In A Migratory Songbird (Protonotaria Citrea), Tyler A. Hohenstein

Theses and Dissertations

In this study I attempted to further resolve the population genetic structure in the Prothonotary Warbler (Protonotaria citrea), and conducted an outlier SNP analysis and exploratory gene ontology analysis to investigate potential ongoing natural selection in the species. This analysis of population structure confirms previous work by DeSaix et al. (2019), where weak population structure was observed between eastern sites along the Atlantic Coastal Plain, and western sites in the Mississippi Alluvial Valley, possibly due to a genetic discontinuity across the Appalachian Mountains. I conducted two forms of outlier SNP analyses, a principal component analysis (PCA)-based approach to identify SNPs …

Disparities Between Native Americans And Whites In Trajectories Of Functional Independence And Life Satisfaction Over The 5 Years After Traumatic Brain Injury, Jack Watson

Theses and Dissertations

A traumatic brain injury (TBI) can have a host of negative consequences including impairments to motor and cognitive function and can result in a decrease in quality of life (i.e., life satisfaction). TBI is one of the leading causes of death and disability worldwide and disproportionately affects Native Americans, who have the highest rates of TBI among all races in the U.S. and elevated likelihood for fatality and severe complications. The current study used a subsample of the national TBI Model Systems Database of 80 demographically and injury severity matched Native American and White individuals (total n = 160) to …

Reds For Ed: Class Struggle In The Classroom, Patrick E. Korte

Theses and Dissertations

Utilizing the methodology of participant observation combined with semi-structured interviews, this ethnographic study aims to analyze the socio-historical development of the Richmond chapter of the Virginia Caucus of Rank-and-file Educators (VCORE), a left-wing opposition group inside the Virginia Education Association (VEA). This study aims to assess VCORE’s politics, origins, growth, transformation, organizational structure, and cultural practices, focusing upon the role VCORE members played in the lead-up to and aftermath of the 2020-2022 campaign to reinstate collective bargaining rights of public education employees in Richmond.

A Method For Predicting Dose Changes For Hn Treatment Using Surface Imaging, Sarah E. Holler

Theses and Dissertations

Head and neck cancer is commonly treated with a six- to seven-week course of radiotherapy, during which a patient’s anatomy may change substantially, due to target reduction or weight loss. Anatomical changes lead to reduction in treatment quality due to decreased setup reproducibility and altered dose deposition compared to the original plan. Few clinics have developed a standard method for triggering resimulation and replan due to anatomic changes. This work investigates a new method for determining when to resimulate and replan HNC patients by utilizing their topographic anatomical changes to predict differences in planned versus delivered dose distributions. The first …

Mobilizing Universalism: The Origins Of Human Rights, Catherine Baylin Duryea

Faculty Publications

Human rights law claims to be universal, setting rights apart from paradigms based on shared religion, culture, or nationality. This claim of universality was a significant factor in the proliferation of human rights NGOs in the 1970s and remains an important source of legitimacy. The universality of human rights has been challenged and contested since they were first discussed at the United Nations (UN). Today, much of the debate centers around the origins of human rights-particularly whether they arose out of Western traditions or whether they have more global roots. For too long, discussions about universality have ignored the practice …

Law, Religion, And The Covid Crisis, Mark L. Movsesian

Faculty Publications

This essay explores judicial responses to legal restrictions on worship during the COVID-19 pandemic and draws two lessons, one comparative and one relating specifically to U.S. law. As a comparative matter, courts across the globe have approached the problem in essentially the same way, through intuition and balancing. This has been the case regardless of what formal test applies, the proportionality test outside the United States, which expressly calls for judges to weigh the relative costs and benefits of a restriction, or the Employment Division v. Smith test inside the United States, which rejects judicial line-drawing and balancing in favor …

Whiteness As Contract, Marissa Jackson Sow

Faculty Publications

2020 forced scholars, policymakers, and activists alike to grapple with the impact of “twin pandemics”—the COVID-19 pandemic, which has devastated Black and Indigenous communities, and the scourge of structural and physical state violence against those same communities—on American society. As atrocious acts of anti-Black violence and harassment by law enforcement officers and white civilians are captured on recording devices, the gap between Black people’s human and civil rights and their living conditions has become readily apparent. Less visible human rights abuses camouflaged as private commercial matters, and thus out of the reach of the state, are also increasingly exposed as …

Establishment’S Political Priority To Free Exercise, Marc O. Degirolami

Faculty Publications

Americans are beset by disagreement about the First Amendment. Progressive scholars are attacking the venerable liberal view that First Amendment rights must not be constricted to secure communal, political benefits. To prioritize free speech rights, they say, reflects an unjust inflation of individual interest over our common political commitments. These disagreements afflict the Religion Clauses as well. Critics claim that religious exemption has become more important than the values of disestablishment that define the polity. Free exercise exemption, they argue, has subordinated establishment.

This Article contests these views. The fundamental rules and norms constituting the political regime—what the Article calls …

Countering The Big Lie: The Role Of The Courts In The Post Truth World, Edward D. Cavanagh

Faculty Publications

(Excerpt)

This Essay analyzes the role of the courts in handling Trump’s election lie. It argues that the courts were certainly correct in giving short shrift to Trump’s lawsuits, but further that the courts should have done more than simply dismiss Trump’s claims. Had the courts aggressively utilized existing tools to identify and punish prosecution of baseless claims, including Rule 11 of the Federal Rules of Civil Procedure and the courts’ inherent powers to control proceedings before them, the Trump election lie might well have been put to rest immediately before it could take root among die-hard Trump supporters. This …

The Unstoppable Spread Of English In The Global University, Rosemary C. Salomone

Faculty Publications

As English has spread across higher education worldwide, it has generated ongoing debate and a wealth of scholarship raising academic and national concerns, but with little, if any, pause or retreat on policies and practices. This article examines that puzzling disconnect within the broader framework of the rise of English as the dominant lingua franca, its historical grounding, its social and economic implications, and its diverse course within Europe and postcolonial countries.

The Unintended Consequence Of Settlement Fever And The Rule Of Law, Elayne E. Greenberg

Faculty Publications

(Excerpt)

Welcome to the final column of a three-part series about how settlement fever has influenced our justice system as it evolves into settlement-centric culture. This column will focus on how the rule of law, once touted as the primary benchmark of justice, has now taken a secondary role to private ordering when shaping some negotiated and mediated settlements.

Employment Status For "Essential Workers": The Case For Gig Worker Parity, Miriam A. Cherry

Faculty Publications

The continuing misclassification of gig workers as independent contractors has been problematic for over a decade. Several misconceptions have contributed to this marginalization of on-demand workers: technology that often obscures the work that is being performed; the view that platform work is a side hustle; or that platform work exists only for customer convenience or frivolous requests. During the coronavirus pandemic these myths about gig work were turned upside down as on-demand workers were recognized for their efforts and labeled essential workers. With that recognition came newly-awarded benefits, like pandemic unemployment assistance and paid sick leave. As such, the events …