Digital Commons Network^™

Multiomics Approach Captures Hepatic Metabolic Network Altered By Chronic Ethanol Administration, Isin Tuna Sakallioglu, Bridget Tripp, Jacy Kubik, Carol A. Casey, Paul G. Thomes, Robert Powers

Chemistry Department: Faculty Publications

Using a multiplatform and multiomics approach, we identified metabolites, lipids, proteins, and metabolic pathways that were altered in the liver after chronic ethanol administration. A functional enrichment analysis of the multiomics dataset revealed that rats treated with ethanol experienced an increase in hepatic fatty acyl content, which is consistent with an initial development of steatosis. The nuclear magnetic resonance spectroscopy (NMR) and liquid chromatography–mass spectrometry (LC-MS) metabolomics data revealed that the chronic ethanol exposure selectively modified toxic substances such as an increase in glucuronidation tyramine and benzoyl; and a depletion in cholesterol-conjugated glucuronides. Similarly, the lipidomics results revealed that ethanol …

Deciphering The Role Of Rna Structure In Translation Efficiency., Jianan Lin, Yang Chen, Yuping Zhang, Haifan Lin, Zhengqing Ouyang

Faculty Research 2022

BACKGROUND: RNA secondary structure has broad impact on the fate of RNA metabolism. The reduced stability of secondary structures near the translation initiation site/start codon of the coding region promotes the efficiency of translation in both prokaryotic and eukaryotic species. However, the inaccuracy of in silico folding and the focus on the coding region limit our understanding of the global relationship between the whole mRNA structure and translation efficiency. Leveraging high-throughput RNA structure probing data in the transcriptome, we aim to systematically investigate the role of RNA structure in regulating translation efficiency.

RESULTS: Here, we analyze the influences of hundreds …

Never Silent: Development Of Gay Activism In The Cold War Midwest, Braydon Conell

History Theses, Dissertations, and Student Creative Activity

Though not typically seen as a burgeoning environment for gay life, the Midwest nevertheless has a rich history of queer culture. Focusing on gay activism during the Cold War era, this thesis discusses the rise and influence of homophile organizations in the Midwest. Homophile organizations and the movement's ideals of accommodation and integration played an integral role in the activism coming out of World War II. The homophile movement, though, did not wane with the development of the more radical gay liberation movement. Instead, the homophile movement in the Midwest evolved and played its own part alongside radical activists. Historically, …

Factors Associated With Improved Outcome Of Inhaled Corticosteroid Use In Covid-19: A Single Institutional Study, A. Manfra, Claire Chen, Kavita Batra, Kyaw Min Tun, Mutsumi Kioka

Internal Medicine Faculty Publications

Asthmatics seem less prone to adverse outcomes in coronavirus disease 2019 (COVID-19) and some data shows that inhaled corticosteroids (ICS) are protective. We gathered data on anecdotal ICS and outcomes of patients hospitalized with COVID-19, given there is literature supporting ICS may reduce risk of severe infection. In addition, we fill gaps in current literature evaluating Charlson Comorbidity Index (CCI) as a risk assessment tool for COVID-19. This was a single-center, retrospective study designed and conducted to identify factors associated intubation and inpatient mortality. A multivariate logistic regression model was fit to generate adjusted odds ratios (OR). Intubation was associated …

Clemson Libraries Inclusive Description Task Force Report, Jessica Serrao, Jim Cross, Scott Dutkiewicz, Charlotte Grubbs, Will Hiott, Shannon Willis

Publications

This report summarizes the findings of the Inclusive Description Task Force presented to the Libraries administration in December 2022. It serves as the final deliverable of the Task Force that outlines the research completed from July to December, presents recommendations on how Clemson Libraries can systemically implement inclusive description practices across all descriptive records, and lists the next steps and prioritized tasks to complete.

Bequest To Help Students In Two Programs Succeed, Bill Dabney

University of Mississippi News

No abstract provided.

Smokejumper Obituary: Hatch, Huntington Talbott (Missoula 1953), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Highly Efficient Photocatalysts For Methylene Blue Degradation Based On A Platform Of Deposited Go-Zno Nanoparticles On Polyurethane Foam, Mohamed Morsy

Nanotechnology Research Centre

No abstract provided.

Highly Efficient Photocatalysts For Methylene Blue Degradation Based On A Platform Of Deposited Go-Zno Nanoparticles On Polyurethane Foam, Mohamed Morsy

Nanotechnology Research Centre

No abstract provided.

A Study On The Effect Of Emotional Efforts Of Academicians In Tourism Departments On Job Stress, Hasan O. Seyhanlioglu, Sevki Ulema

Journal of Mediterranean Tourism Research

The aim of this study is to examine the emotional labor and job stress levels of tourism academicians who train sector managers. The t-test and One-Way ANOVA analysis were conducted to determine whether there is a difference between the quantitative data collected from 346 individuals working as academicians in tourism departments operating in Turkey and the demographic characteristics of the variables. In addition, explanatory factor analysis was performed for the emotional labor scale. As a result, it has been observed that the stress level is high in academicians who have just started their profession.

Behavioral Strategies Of Prehistoric And Historic Children From Dental Microwear Texture Analysis, Almudena Estalrrich, Kristin L. Krueger

Anthropology: Faculty Publications and Other Works

Reconstructing the dietary and behavioral strategies of our hominin ancestors is crucial to understanding their evolution, adaptation, and overall way of life. Teeth in general, and dental microwear specifically, provide a means to examine these strategies, with posterior teeth well positioned to tell us about diet, and anterior teeth helping us examine non-dietary tooth-use behaviors. Past research predominantly focused on strategies of adult individuals, leaving us to wonder the role children may have played in the community at large. Here we begin to address this by analyzing prehistoric and historic children through dental microwear texture analysis of deciduous anterior teeth.

Impact Of Forearm Pronation On Ultrasound-Measured Forearm Muscle Thickness In Children And Adolescents, Takashi Abe, Hayao Ozaki, Akemi Abe, Jeremy P. Loenneke

Faculty and Student Publications

Background and Aim: It was unknown whether ultrasound-measured forearm muscle thickness was impacted by pronation of the forearm. The aim of this study was to investigate the influence of forearm pronation on two forearm muscle thicknesses (MT-ulna and MT-radius). Participants and Methods: Fourteen healthy children and adolescents sat on a chair with their right arm comfortably on a table, and their hands were fixed to the board with elastic bands. The probe was placed perpendicularly over the forearm, and the angle of the board was then pronated in 5° increments from -10° to 30°. The average value of the two …

Complete Corpus Callosotomy Using A Frameless Navigation Probe Through A Minicraniotomy In Children With Medically Refractory Epilepsy: A Case Series And Technical Note, Ahmed Belal, Gretchen Von Allmen, Indira Kommuru, Jeremy Lankford, John C Mosher, Manish Shah, Michael Funke, Michael Watkins, Rajan Patel

Journal Articles

Background:

Medically refractory epilepsy constitutes up to one-third of the epilepsy pediatric patients. Corpus callosotomy (CC) has been used for the treatment of medically refractory epilepsy in children with atonic seizures and generalized tonic–clonic (GTC) seizures. In this case series study, we are describing a novel technique for CC using the frameless navigation probe through a minicraniotomy.

Methods:

Thirteen pediatric patients with the diagnosis of medically refractory epilepsy predominantly GTC with drop attack who underwent extensive Phase I. An L-shape was done, then through a 4 × 3 cm craniotomy, we were able to open the interhemispheric fissure until the …

Hiv-Tat Exacerbates The Actions Of Atazanavir, Efavirenz, And Ritonavir On Cardiac Ryanodine Receptor (Ryr2), Imam Abdulrahman Bin Faisal University, Chengju Tian, Sean R. Bidasee, Zachary L. Venn, Evan Schroder, Nick Y. Palermo, Mohammad Alshabeeb, Benson J. Edagwa, Jason J. Payne, Keshoer R. Bidasee

Department of Biochemistry: Faculty Publications

The incidence of sudden cardiac death (SCD) in people living with HIV infection (PLWH), especially those with inadequate viral suppression, is high and the reasons for this remain incompletely characterized. The timely opening and closing of type 2 ryanodine receptor (RyR2) is critical for ensuring rhythmic cardiac contraction–relaxation cycles, and the disruption of these processes can elicit Ca²⁺ waves, ventricular arrhythmias, and SCD. Herein, we show that the HIV protein Tat (HIVTat: 0–52 ng/mL) and therapeutic levels of the antiretroviral drugs atazanavir (ATV: 0–25,344 ng/mL), efavirenz (EFV: 0–11,376 ng/mL), and ritonavir (RTV: 0–25,956 ng/mL) bind to and modulate the …

Yield Prediction Through Integration Of Genetic, Environment, And Management Data Through Deep Learning, Daniel R. Kick, Jason G. Wallace, James C. Schnable, Judith M. Kolkman, Barış Alaca, Timothy M. Beissinger, Jode Edwards, David Ertl, Sherry Flint-Garcia, Joseph L. Gage, Candice N. Hirsch, Joseph E. Knoll, Natalia De Leon, Dayane C. Lima, Danilo E. Moreta, Maninder P. Singh, Addie Thompson, Teclemariam Weldekidan, Jacob D. Washburn

Department of Agronomy and Horticulture: Faculty Publications

Accurate prediction of the phenotypic outcomes produced by different combinations of genotypes, environments, and management interventions remains a key goal in biology with direct applications to agriculture, research, and conservation. The past decades have seen an expansion of new methods applied toward this goal. Here we predict maize yield using deep neural networks, compare the efficacy of 2 model development methods, and contextualize model performance using conventional linear and machine learning models. We examine the usefulness of incorporating interactions between disparate data types. We find deep learning and best linear unbiased predictor (BLUP) models with interactions had the best overall …

Two Sides To Every Psyche: Implications Of Positive Psychology For "Mental Health" Research In Engineering Education, Muhammad Asghar, Angela Minichiello

Engineering Education Student Research

“Mental Health.” Throughout the 20th century, these familiar words have been quietly commandeered by a physiological model of health (Greenspoon & Saklofske, 2001). Unknowingly, society conspired to use these words—colloquially, academically, and scientifically—for the sole purpose of depicting (or implying) negative states of the human mind. Since the origins of psychological research over 100 years ago, our understanding of what mental health is has been conflated with notions of mental illness. Resultantly, we have tacitly agreed that the presence or absence of suffering is the sole implication of our mental health (Horwitz & Scheid, 1999).

The Impact Of The Covid-19 Pandemic On Risk Factors For Fatal Intimate Partner Violence And Domestic Violence Services Provided, Faith E. Alves

Honors Theses

The current study assessed the COVID-19 pandemic-related changes in risk factors for fatal intimate partner violence (IPV) among female victims. It additionally analyzed IPV services received before and during the pandemic. Data came from a system that most domestic violence (DV) agencies in Connecticut utilize to record their contacts with their clients, including an initial screening through a police-social service intervention. Results indicated that unemployment of the partner was significantly higher in the during-COVID group. Additionally, the delivery of criminal justice services was significantly higher in the pre-COVID group whereas delivery of law enforcement services was significantly higher in the …

Knowledge Mobilization For Agri-Food Supply Chain Decisions, Guoqing Zhao, Shaofeng Liu, Sebastian Elgueta, Juan Pablo Manzur, Carmen Lopez, Huilan Chen

Plymouth Business School

The current world business environment is characterized by increasing uncertainties, complexities, and risks, which require agri-food supply chain (AFSC) managers to respond and act quickly in a context full of instability and unpredictability. Increasing pressure placed on AFSC managers intensifies the need to combine knowledge management (KM) and decision support that rapidly overcome knowledge boundaries. It has been recognized that the research issue related to the knowledge mobilization crossing boundaries in the AFSC needs to be addressed. This paper investigates knowledge boundaries and boundary-spanning mechanisms by collecting data from experienced AFSC practitioners. Empirical results verify that knowledge boundaries such as …

Optimal Base Placement Of A 6-Dofs Robot To Cover Essential Activities Of Daily Living, Javier Dario Sanjuan De Caro, Md. Samiul Haque Sunny, Elias Jose Muñoz Montenegro, Helal Uddin Ahmed, Mohammad Habib Rahman

Mechanical Engineering Faculty Articles

The number of individuals with upper or lower extremities dysfunction (ULED) has considerably increased in the past decades resulting in a high economic burden for the families and society. Individuals with ULEDs require assistive robots to fulfill all their activities of daily living (ADLs). Thus, this research presents an objective function for base placement optimization of assistive robots to increase the workspace required to fulfill ADLs (workspace coverage). The workspace coverage was determined using the xArm 6 robot and experimenting with different ADLs. Also, an object collision algorithm is implemented to avoid collisions between the robot and the user within …

Roles Played By Nigerian Youtube Micro-Celebrities During The Covid-19 Pandemic, Aje-Ori Agbese

Communication Faculty Publications and Presentations

In 2020, during the COVID-19 pandemic, Nigerian social media micro-celebrities were prominent players in the dissemination of information. This study examines the roles that one group of Nigerian micro-celebrities, YouTube video bloggers (vloggers)—also known as “YouTubers”—played during the pandemic. The research analysed the contents of COVID-19-themed videos that 15 popular Nigerian YouTubers posted on their channels between 29 February and 5 August 2020. The study was guided by the two-step flow of communication theory, in terms of which information first flows from mass media to opinion leaders, who then, in the second step, share the information with their audiences. The …

The 1980 Eruptions Of Mount St. Helens: Disregard For Volcanic Hazards And Its Effects On State Preparedness, Jeffrey Derouen

History Undergraduate Theses

This paper works to identify the disregard for volcanic hazards in the Cascades and how that affected the emergency response to the Mount St. Helens eruption. Using executive orders from prior governors, documents issued by the USGS, and prior volcanic activity, this paper works to identify why the state was so unprepared for the eruption, when they had received so much prior warning and experience of the hazards of these cascade volcanoes,

Captain James Cook And His Fight Against The Invisible: A Closer Look At The Diseases That Plagued The Voyages Of Discovery, Gabby Quinnett

History Undergraduate Theses

A look into Captain James Cook's battle against the diseases he, his crew, and the Pacific Natives faced between 1768-1779.

Emulating Future Neurotechnology Using Magic, Jay A. Olson, Mariève Cyr, Despina Z. Artenie, Thomas Strandberg, Lars Hall, Matthew L. Tompkins, Amir Raz, Petter Johansson

Psychology Faculty Articles and Research

Recent developments in neuroscience and artificial intelligence have allowed machines to decode mental processes with growing accuracy. Neuroethicists have speculated that perfecting these technologies may result in reactions ranging from an invasion of privacy to an increase in self-understanding. Yet, evaluating these predictions is difficult given that people are poor at forecasting their reactions. To address this, we developed a paradigm using elements of performance magic to emulate future neurotechnologies. We led 59 participants to believe that a (sham) neurotechnological machine could infer their preferences, detect their errors, and reveal their deep-seated attitudes. The machine gave participants randomly assigned positive …

Machine Learning Of Plasma Metabolome Identifies Biomarker Panels For Metabolic Syndrome: Findings From The China Suboptimal Health Cohort, Hao Wang, Youxin Wang, Xingang Li, Xuan Deng, Yuanyuan Kong, Wei Wang, Yong Zhou

Research outputs 2022 to 2026

Background: Metabolic syndrome (MetS) has been proposed as a clinically identifiable high-risk state for the prediction and prevention of cardiovascular diseases and type 2 diabetes mellitus. As a promising “omics” technology, metabolomics provides an innovative strategy to gain a deeper understanding of the pathophysiology of MetS. The study aimed to systematically investigate the metabolic alterations in MetS and identify biomarker panels for the identification of MetS using machine learning methods. Methods: Nuclear magnetic resonance-based untargeted metabolomics analysis was performed on 1011 plasma samples (205 MetS patients and 806 healthy controls). Univariate and multivariate analyses were applied to identify metabolic biomarkers …

Risk Factors For Sars-Cov-2 Transmission In Close Contacts Of Adults At High Risk Of Infection Due To Occupation: Results From The Contact Tracing Strategy Of The Covida Epidemiological Surveillance Study In Bogotá, Colombia, In 2020-2021, Andrea Ramírez Varela, Sandra Contreras-Arrieta, Guillermo Tamayo-Cabeza, Leonardo Salas Zapata, Yuldor Caballero-Díaz, Luis Jorge Hernández Florez, Andrés Patiño Benavidez, Rachid Laajaj, Fernando De La Hoz, Giancarlo Buitrago Gutierrez, Silvia Restrepo, Eduardo Behrentz

Journal Articles

OBJECTIVES: To estimate the risk factors for SARS-CoV-2 transmission in close contacts of adults at high risk of infection due to occupation, participants of the CoVIDA study, in Bogotá D.C., Colombia.

SETTING: The CoVIDA study was the largest COVID-19 intensified sentinel epidemiological surveillance study in Colombia thus far, performing over 60 000 RT-PCR tests for SARS-CoV-2 infection. The study implemented a contact tracing strategy (via telephone call) to support traditional surveillance actions performed by the local health authority.

PARTICIPANTS: Close contacts of participants from the CoVIDA study.

PRIMARY AND SECONDARY OUTCOME MEASURES: SARS-CoV-2 testing results were obtained (RT-PCR with CoVIDA …

The Stockholm Paradigm Explains The Dynamics Of Darwin’S Entangled Bank, Including Emerging Infectious Disease, Salvatore J. Agosta

MANTER: Journal of Parasite Biodiversity

Pathogens and their hosts are embedded within the larger biosphere, what Darwin called the “entangled bank.” Emerging infectious disease occurs when a parasite “switches” to a new host. Understanding the dynamics of emerging disease requires understanding the dynamics of host-switching, which requires a more general understanding of how the biosphere and its constituent members cope when conditions change. The Stockholm paradigm is an integrative evolutionary framework that describes how living systems cope with change by oscillating between exploiting and exploring the geographical and functional dimensions of their environments. It combines organismal capacity, ecological opportunity, and the repeated external perturbations to …

Late Descemet Membrane Detachment After Uneventful Cataract Surgery, Lovaglio Cançado Trindade, Renata Attanasio De Rezende, Tiago Bisol, Christopher J Rapuano

Wills Eye Hospital Papers

Purpose: To report 5 patients with late Descemet membrane (DM) detachment after uneventful cataract surgery.

Observations: After a retrospective chart analysis of consecutive patients that developed DM detachment after uneventful cataract surgery, six eyes of five patients were enrolled. In all cases, patients reported good vision initially after cataract surgery. Within days to months, these patients developed late DM detachment with decreased vision. In one patient, the detachment affected both eyes. Filtered air or diluted sulfur hexafluoride were injected in the anterior chamber to tamponade the DM detachment. In five eyes, the cornea cleared after DM reattachment. In two eyes …

30 Años De Transformacion Regional Ubate, Myriam Rocío Páez Saboya, Ana Lucia Hurtado Mesa, Carlos Felipe Bosa Ochoa, César Rodríguez Buitrago, Cristian Eduardo Cano López, Daniel Humberto Arévalo Sierra, Guillermo León Murcia, Javier Cortés Cortés, Johanna Andrea Gil Palacios, John Henry Vásquez Calderón, Luis Eduardo Sánchez Sarrazola, Luisa Johana Lara Rodríguez, Marbel Yulieth Monroy González, Miguel Alejandro Flechas Montaño, Sandra Milena Melo Perdomo, Segundo Leonardo Cortes, Yeny Liliana Casas Méndez

Institucional

El desarrollo del proyecto permitió establecer el estado actual de los planes de estudio vigentes a la fecha, con el fin de realizar y presentar la propuesta de resignificación curricular con los resultados de la fase diagnóstica, adicional al estudio comparativo con programas de administración de empresas acreditados en alta calidad de instituciones de educación superior nacionales e internacionales. Esto dio como resultado el documento con el diseño macro y microcurricular contribuyendo a la solución de necesidades y demandas del entorno local, regional e internacional y en la comprensión de la transformación indispensable para alinear la propuesta al modelo educativo …

30 Años De Transformación Regional. Chía Y Zipaquirá, José Zacarías Mayorga Sánchez, Luz Deicy Flórez Espinal, Viviana Andrea Caballero Moreno, Luz Mireya Rincón Mora, John Jairo Zambrano Rocha, Eduard Neftali Gutiérrez, Carlos Augusto Trujillo Padilla, Carlos Germán González Pedraza, Juan Manuel Urrego Laurin, León Fabio Salcedo Ortiz, Ana Betina Morgante Combariza, Eduardo Ernesto Castro Neira

Institucional

En el trigésimo aniversario de vida universitaria de nuestro claustro académico, la Extensión Chía, recordamos con agrado el proceso desarrollado en esta corta pero muy exitosa actividad universitaria. Conocida como la ciudad de La Luna, el municipio de Chía es un importante centro empresarial e industrial del departamento de Cundinamarca, sede de varias instituciones de educación superior. Hoy es un referente de primer orden el proceso de desarrollo económico y social que ha atravesado la provincia Sabana Centro, en especial, debido a la cercanía a la capital del país. Es un centro cultural y turístico por excelencia con una rica …

Using Naming Conventions To Facilitate Data Transfer Between Asset Management Systems And Building Information Models, John D. Foster

Theses and Dissertations

An improvement to the workflow developed by Loeh et al. (2021) is proposed using a Revit template with BUILDER SMS naming conventions when creating the Sustainable Facility Management-enhanced BIM Model. The method presented by Loeh et al. (2021) is modified by integrating BUILDER SMS parameters and naming conventions into the BIM model during, as opposed to after, the creation of the model. Four building models created in 2020-21, four from 2021-22, and one building from 2019 were used in this study. Two groups of students were used to evaluate the effect of the building-specific BIM templates. Evaluating the 2020 and …