Digital Commons Network^™

Spaci: Deciphering Spatial Cellular Communications Through Adaptive Graph Model, Ziyang Tang, Tonglin Zhang, Baijian Yang Ph.D., Jing Su, Qianqian Song

Publications

Cell-cell communications are vital for biological signalling and play important roles in complex diseases. Recent advances in single-cell spatial transcriptomics (SCST) technologies allow examining the spatial cell communication landscapes and hold the promise for disentangling the complex ligand-receptor (L-R) interactions across cells. However, due to frequent dropout events and noisy signals in SCST data, it is challenging and lack of effective and tailored methods to accurately infer cellular communications. Herein, to decipher the cell-to-cell communications from SCST profiles, we propose a novel adaptive graph model with attention mechanisms named spaCI. spaCI incorporates both spatial locations and gene expression profiles of …

Knowing The Biosphere: Documentation, Specimens, Archives, And Names Reveal Environmental Change And Emerging Pathogens, Eric P. Hoberg, Valeria Trivellone, Joseph A. Cook, Jonathan L. Dunnum, Walter A. Boeger, Daniel R. Brooks, Salvatore J. Agosta, Jocelyn P. Colella

MANTER: Journal of Parasite Biodiversity

One Health programs and trajectories are now the apparent standard for exploring the occurrence and distribution of emerging pathogens and disease. By definition, One Health has been characterized as a broadly inclusive, collaborative, and transdisciplinary approach with connectivity across local to global scales, which integrates the medical and veterinary community to recognize health outcomes emerging at the environmental nexus for people, animals, plants, and their shared landscapes. One Health has been an incomplete model, conceptually and operationally, focused on reactive and response-based foundations, to limit the impact of emerging pathogens and emerging infectious diseases and, as such, lacks a powerful …

Implementation Of The Family Help Protocol: A Feasibility Project For A West Texas Icu, Rebecca Mcclay

Dissertations

The purpose of this project was to determine if there is sufficient bedside ICU nurse buy-in to the Family HELP protocol to make implementation feasible at one county hospital in West Texas.

Extracellular Vesicle Characteristics And Micro Rna Content In Cerebral Palsy And Typically Developed Individuals At Rest And In Response To Aerobic Exercise., Ivan Jose Vechetti Jr, Jessica Norrbom, Björn Alkner, Emma Hjalmarsson, Alexandra Palmcrantz, Eva Pontén, Jessica Pingel, Ferdinand Von Walden, Rodrigo Fernandez-Gonzalo

Department of Nutrition and Health Sciences: Faculty Publications

In this study, the properties of circulating extracellular vesicles (EVs) were examined in cerebral palsy (CP) and typically developed (TD) individuals at rest and after aerobic exercise, focusing on the size, concentration, and microRNA cargo of EVs. Nine adult individuals with CP performed a single exercise bout consisting of 45 min of Frame Running, and TD participants completed either 45 min of cycling (n = 10; TD EX) or were enrolled as controls with no exercise (n = 10; TD CON). Blood was drawn before and 30 min after exercise and analyzed for EV concentration, size, and microRNA …

Factors Influencing Young Consumers’ Impulse Intentions Toward Visiting Pop-Up Stores In South Africa, Miriam-Miri Retief, Bertha Jacobs, Ann-Marie Fiore

Journal of Marketing and Consumer Behaviour in Emerging Markets

Consumers are constantly seeking out new and memorable experiences. This study empirically examines how external factors, such as the characteristics of innovation (relative advantage, trialability, observability, low complexity, compatibility) and exterior store design, and internal factors (positive mood, hedonic motivations, consumer innovativeness) aff ect young consumers’ impulse intention toward visiting pop-up stores in the South African context. Survey data was collected from a convenient sample of 461 students from two universities in South Africa via a self-administered questionnaire. Multiple regression analysis revealed that (a) external factors related to the characteristics of innovation (i.e., compatibility and low complexity), (b) exterior store …

Four Students Receive Grants For Ideas Through Titan New Venture Challenge, Mj Soria

News and Events (Discontinued Series)

No abstract provided.

Dissecting The Recruitment And Self-Organization Of Αsma-Positive Fibroblasts In The Foreign Body Response, Maria Parlani, Matthew L Bedell, Antonios G Mikos, Peter Friedl, Eleonora Dondossola

Faculty, Staff and Student Publications

The foreign body response (FBR) is a clinically relevant issue that can cause malfunction of implanted medical devices by fibrotic encapsulation. Whereas inflammatory aspects of the FBR have been established, underlying fibroblast-dependent mechanisms remain unclear. We here combine multiphoton microscopy with ad hoc reporter mice expressing α-smooth muscle actin (αSMA) protein to determine the locoregional fibroblast dynamics, activation, and fibrotic encapsulation of polymeric materials. Fibroblasts invaded as individual cells and established a multicellular network, which transited to a two-compartment fibrotic response displaying an αSMA cold external capsule and a long-lasting, inner αSMA hot environment. The recruitment of fibroblasts and extent …

Can A Combined Agriculture And Nutrition Behaviour Change Intervention Improve Women’S Empowerment? A Mixed Methods Feasibility Study In Rural Bangladesh, Elizabeth K. Kirkwood, Michael J. Dibley, Wajiha Khatun, Gulshan Ara, Mansura Khanam, Anowarul Bokshi, Mu Li, Neeloy Ashraful Alam

The Qualitative Report

Many agricultural and home gardening interventions aim to improve the nutritional status of women and children in low- and middle-income countries by focusing on women as the recipients of the intervention and make assumptions that women will be empowered as a result. This paper examines the potential impact of an intervention study that combined home garden training and support, and nutrition behaviour change communication, with a social safety net payment, on women’s empowerment in rural Bangladesh. We assessed the implementation of this study in terms of feasibility, acceptability, and practical application. Twenty in-depth interviews were conducted with randomly selected women …

Overqualified And Underrepresented: Gender Inequality In Pharmaceutical Patent Law, S. Sean Tu, Paul R. Gugliuzza, Amy Semet

Journal Articles

Pharmaceutical patents represent some of the most valuable intellectual property assets in the world: they can be worth billions of dollars if courts uphold their validity and find them infringed. But, if invalidated, generic drug manufacturers can get to market earlier, generating billions of dollars of revenue for themselves and creating enormous savings for consumers. Accordingly, drug patents are the product of careful, high-cost prosecution and are associated with high-stakes, bet-the-company litigation. But women lawyers are noticeably absent from pharmaceutical patent practice. This article reports an original empirical study finding that women comprise only one-third of the top pharmaceutical patent …

Implementing Dei In Aviation Education: Coping And Addressing Mental Health Concerns, Jorge L. D. Albelo Ph.D., Michael F. O'Toole Ph.D., Samantha Bowyer

Publications

In recent years, different global events have led to increased awareness of the benefits of promoting diversity, equity, and inclusion in the workplace and education. Notably, the aviation industry is seeing increased research initiatives to promote DEI among all generations. Nevertheless, given the rising concerns about mental health in higher education, this paper sought to connect coping and addressing mental health through implementing DEI teachings in aviation education. Integrating DEI in the aviation classroom can be challenging, as many faculty members might feel uncomfortable addressing the topic in their courses. Consequently, the researchers proposed and tested an aviation education approach …

Medical Racism: Comparing Prenatal Care Across Races In The United States, Rubina Cheema

Student Research

Prenatal care describes any care a woman receives during her pregnancy. It is intended to keep both the mother and the child healthy and also to reduce the risk of complications during and after birth. This care is especially important for women with high-risk factors so that doctors and nurses are able to monitor their health and the health of their baby during the duration of their pregnancy. For prenatal care to be most effective, it is imperative to begin prenatal care within the first trimester of a woman's pregnancy. However, in the United States, medical racism creates a major …

Ototoxicity Of Topical Antibiotic Ear Drops In Chronic Suppurative Otitis Media In Humans: A Review Of The Literature, Syed Zohaib Maroof Hussain, Syed S Hashmi, Asad Qayyum

Faculty, Staff and Student Publications

An electronic search of the literature was performed for reported cases of ototoxicity associated with the use of topical antibiotic ear drops in humans. The dosage, duration, and type of ototoxic preparations involved were recorded. Due to the scant quantity of low-quality information that is currently available, there was uncertainty about the usefulness of topical antibiotics in enhancing the resolution of ear discharge in patients with chronic suppurative otitis media. However, despite this uncertainty, there are some data to show that using topical antibiotics in comparison to a placebo or in conjunction with a systemic antibiotic may be useful. Additionally, …

Molecular Markers In Maternal Blood Exosomes Allow Early Detection Of Fetal Alcohol Spectrum Disorders, Nune Darbinian, Armine Darbinyan, John Sinard, Gabriel Tatevosian, Nana Merabova, Faith D'Amico, Tarek Khader, Ahsun Bajwa, Diana Martirosyan, Alina K Gawlinski, Richa Pursnani, Huaqing Zhao, Shohreh Amini, Mary Morrison, Laura Goetzl, Michael E Selzer

Faculty, Staff and Student Publications

Prenatal alcohol exposure can cause developmental abnormalities (fetal alcohol spectrum disorders; FASD), including small eyes, face and brain, and neurobehavioral deficits. These cannot be detected early in pregnancy with available imaging techniques. Early diagnosis could facilitate development of therapeutic interventions. Banked human fetal brains and eyes at 9−22 weeks’ gestation were paired with maternal blood samples, analyzed for morphometry, protein, and RNA expression, and apoptotic signaling. Alcohol (EtOH)-exposed (maternal self-report) fetuses were compared with unexposed controls matched for fetal age, sex, and maternal race. Fetal brain-derived exosomes (FB-E) were isolated from maternal blood and analyzed for protein, RNA, and apoptotic …

The Association Between Adverse Childhood Experiences, Self-Silencing Behaviours And Symptoms In Women With Fibromyalgia., Alison M. Bacon, Leah White

School of Psychology

Poor adult health has consistently been associated with Adverse Childhood Experiences (ACEs). The process is not fully understood but is likely to involve a complex interaction of biological and psychosocial factors. Early life stress can affect the developing brain resulting in long-term hyper-responses to stress and raised inflammatory biomarkers. Women with fibromyalgia syndrome (FMS) frequently report ACEs and also self-sacrificial behaviours whereby they repress their own needs and emotions to preserve personal relationships. This behavioural profile (termed self-silencing) may develop following ACEs but has not previously been considered in the context of FMS. This study examined whether self-silencing mediates the …

Migrant Visits Over Time: Ethnographic Returning And The Technological Turn, Loretta Baldassar

Research outputs 2022 to 2026

This paper reflects on four decades of research (via ethnographic returning) to explore the social transformations in travel and communication technologies that have impacted the lived experiences, and consequently the theoretical conceptualization, of migrant visits. A comparison of migration waves between Italy and Australia reveals both continuities in visiting experience as deeply relational practices that facilitate a mutuality of being, but also transformations brought about by the technological turn. Visits take on different meanings depending on individual/ family life stage, generation, and community and national histories. The capacity for both physical and virtual copresence must be understood as coconstitutive, requiring …

Computer Ergonomics And Computer-Related Illnesses: The Experience Of Library Personnel, Olaide Akinbo, Damilare Andrew Omideyi

Library Philosophy and Practice (e-journal)

The deployment and frequent use of Information and Communication Technologies (ICTs) in carrying out library tasks had long been leading to computer-related illnesses among library personnel especially in academic libraries. The designing of computer ergonomics in most academic libraries were observed to be affecting the wellbeing and productivity of library personnel. This study was carried out to investigate computer ergonomics and computer-related illnesses: the experience of library personnel.

The study adopted the survey research design with a study population of 60 library personnel in University of Lagos (UNILAG) and Michael Otedola College of Primary Education (MOCPED) libraries, Lagos State, …

Influence Of Reading Habit On Perception And Use Of Reference Sources By Postgraduate Students In The Faculty Of Education Of Ibadan, Nigeria, Sunday A. Oluwaniyi, Lawrence Akingbade

Library Philosophy and Practice (e-journal)

Abstract

Libraries play a critical role in promoting reading habits. If postgraduate students cultivate the habits of reading, their perception and use of reference sources will be enhanced. The main objective is to determine the influence of reading habits on the perception and use of reference sources by postgraduates in the Faculty of Education, University of Ibadan. Descriptive survey research design was adopted for the study and the study population consisted of 2503 postgraduate students of the Faculty of Education, University of Ibadan, Nigeria, Stratified random sampling technique was used to select the sample size of 337 and tie questionnaire …

Weakly-Supervised Learning Method For The Recognition Of Potato Leaf Diseases, Junde Chen, Xiaofang Deng, Yuxin Wen, Weirong Chen, Adnan Zeb, Defu Zhang

Engineering Faculty Articles and Research

As a crucial food crop, potatoes are highly consumed worldwide, while they are also susceptible to being infected by diverse diseases. Early detection and diagnosis can prevent the epidemic of plant diseases and raise crop yields. To this end, this study proposed a weakly-supervised learning approach for the identification of potato plant diseases. The foundation network was applied with the lightweight MobileNet V2, and to enhance the learning ability for minute lesion features, we modified the existing MobileNet-V2 architecture using the fine-tuning approach conducted by transfer learning. Then, the atrous convolution along with the SPP module was embedded into the …

A Mobile Phone Text Messaging Intervention To Manage Fatigue For People With Multiple Sclerosis, Spinal Cord Injury, And Stroke: Development And Usability Testing, Kerri A. Morgan, Alex W K Wong, Kim Walker, Rachel Heeb Desai, Tina M Knepper, Pamela K Newland

2020-Current year OA Pubs

BACKGROUND: Fatigue significantly affects daily functioning in persons with disabilities. Fatigue management can be challenging, and the information provided during routine physician visits to manage fatigue can be overwhelming. One way to address fatigue is to increase knowledge, skills, and confidence for self-management (ie, patient activation). Self-management programs have shown promising effects in targeting fatigue in persons with disabilities. However, satisfaction with self-management programs is low for persons with disabilities, and tailoring interventions to personalized needs has been recommended. SMS text messaging is increasingly being used to implement health behavior change interventions in a person's natural environment. Little has been …

Machine Learning And Protein Allostery, Sian Xiao, Gennady M. Verkhivker, Peng Tao

Mathematics, Physics, and Computer Science Faculty Articles and Research

The fundamental biological importance and complexity of allosterically regulated proteins stem from their central role in signal transduction and cellular processes. Recently, machine-learning approaches have been developed and actively deployed to facilitate theoretical and experimental studies of protein dynamics and allosteric mechanisms. In this review, we survey recent developments in applications of machine-learning methods for studies of allosteric mechanisms, prediction of allosteric effects and allostery-related physicochemical properties, and allosteric protein engineering. We also review the applications of machine-learning strategies for characterization of allosteric mechanisms and drug design targeting SARS-CoV-2. Continuous development and task-specific adaptation of machine-learning methods for protein allosteric …

Impact Of Covid-19 On A Worksite Weight Loss Program For Employees With Overweight And Obesity, Che Young Lee, Michael C Robertson, Kendahl Servino, Thuan Le, Margaret Raber, Katherine Oestman, Karen M Basen-Engquist

Faculty, Staff and Students Publications

OBJECTIVE: The COVID-19 pandemic has been shown to be negatively associated with physical activity engagement, adherence to healthy diet, and weight management among people with obesity. The current study examined COVID-19-related changes in weight, physical activity (PA), and diet among employees with obesity or overweight who participated in Vibrant Lives (VL), a worksite weight loss program.

METHODS: School district employees participated in the 6-month VL weight loss program and were categorized into non-COVID-era participants and COVID-era participants. Participants completed questionnaires about PA and dietary intake at baseline and follow-up. COVID-era participants reported the effects of pandemic on their behaviors. Changes …

Systemic Delivery Of Divalent Europium From Ligand Screening With Implications To Direct Imaging Of Hypoxia, Md Mamunur Rashid, Brooke A Corbin, Pavan Jella, Caitlyn J Ortiz, Md Abul Hassan Samee, Robia G Pautler, Matthew J Allen

Faculty, Staff and Students Publications

Hypoxia is a hallmark of many diseases, including cancer, arthritis, heart and kidney diseases, and diabetes, and it is often associated with disease aggressiveness and poor prognosis. Consequently, there is a critical need for imaging hypoxia in a noninvasive and direct way to diagnose, stage, and monitor the treatment and development of new therapies for these diseases. Eu-containing contrast agents for magnetic resonance imaging have demonstrated potential for in vivo imaging of hypoxia via changes in metal oxidation state from +2 to +3, but rapid oxidation in blood limits EuII-containing complexes to only studies compatible with direct injection to sites. …

A Method And System For Selection Of Payment Cards For Transactions After Pre-Stipulated Time Periods, Aditi Rungta, Jozua Heng, Edwin Kai Cong Tay, Way Zheng Calven Lim, Lutong Zhao

Defensive Publications Series

The present disclosure relates to a method and system for providing selection of payment cards for transactions after pre-stipulated time periods. The method includes generating a universal token for a consumer, such that the universal token is mapped to the consumer’s payment cards. Thereafter, the universal token is utilised for a transaction. In order for the transaction to be authorised, the universal token is authorised by issuing agencies. At an end of the pre-stipulated time period, the consumer may pay for purchases by choosing a payment card from a plurality of payment cards for each transaction made using the universal …

Liberating The Truth In Augustine’S Confessions And Douglass’ Narrative, Vincent Hanrahan

Compass: An Undergraduate Journal of American Political Ideas

In this paper, I explore how Frederick Douglass’ and St. Augustine's understanding of the corruption of God's word produced their respective achievement of freedom. In examining Augustine’s Confessions and Douglass’ Narrative, we come to understand the moral imperative of public service both thinkers promoted; the idea that individuals have a distinct social obligation to share their knowledge in a promotion of the greater good.

An Educator’S Reflection On The Importance Of Embodiment, Imagination, And Liberation, Ashley N. Gibson

Journal of Multicultural Affairs

This reflection piece offers an interpretation of the years 2020-2021, through the earliest days of the COVID-19 pandemic and the racial awakenings in the US. Writing at the intersections of race, gender, and religion, this piece is part essay, part spoken word, and part treatise. The ultimate call to action is threefold; we must lean into embodiment as a habit for living, use our imaginations, and seek liberation for ourselves and one another if we are to hope for a better future. While many aspects of life now seem bleak, there is hope if we consider these three principles for …

Doctoral Studies As Learning To Rename The World, Hyleen Mariaye

Journal of Multicultural Affairs

The reflective experience documented in this paper engages with doctoral learning from Freire’s (1968/2000) conceptual lens of naming the world. Written from the narrative lens of the supervisor, it considers how doctoral level studies in education can position both the supervisor and the candidates as agents actively reconstructing their understanding of the world and their place in it. The doctoral journey is viewed as praxis compelling researchers to expand their frames for reading the world, accommodating the other, including multiple voices and thus demonstrating commitment to a global and yet constantly contested notion of citizenship.

A Content Analysis Of Educators’ Perceptions Of Anti-Black Bias: Implications For Black Students, Monica R. Brown

Journal of Multicultural Affairs

Recent research and scholarship have highlighted anti-Black bias in today’s schools. This study explored the perceptions that in-service educators had regarding the ways anti-Black bias is represented in schools. This basic qualitative study included one open-ended question that investigated school personnel’s perspectives regarding how anti-Black bias is represented in the schools. A qualitative content analysis was performed on the open-ended question. Participants included 18 in-service educators enrolled in a summer multicultural special education course that is a required course in the department’s special education master’s program. Results from the content analysis yielded 47 unique statements from 18 responses. From the …

Poetry And Praxis: Lessons From An Activist Educator, Dr. Emmanuel Tabi

Journal of Multicultural Affairs

Drawing on data from a narrative multi-case study based in Toronto, Canada, this article discusses the lived experiences of one Black activist. Utilizing critical race theory, new literacy studies and the rhetoric of cultural production as theoretical frameworks, the article foregrounds the work of Ebele, a Toronto activist whose work supported the educational trajectories and emotional well-being of Black students, many of whom reported being marginalized in school. Through his creative labor, Ebele directly addressed the sociology of anti-Black racism that deeply influences the lives of Afrodiasporic people in Canada. This article continues the conversation about what it means to …

Vol. 37 No. 4 - Whole No. 217, Eleanor M. Farrell

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 37 No. 2 - Whole No. 215, Eleanor M. Farrell

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.