Digital Commons Network^™

A Cell Culture Model To Study Tobacco Associated Oral Cancer Progression And Treatment Resistance, Amanda Busch

Theses & Dissertations

Head and Neck Squamous cell carcinoma is the 6^th most common cancer in the world. Risk factors for HNSCC include alcohol and tobacco consumption, infection with Human Papilloma Virus, and exposure to environmental toxins. Unlike many other cancers, the incidence of HNSCC is growing, yet the treatment options and outcomes have not been significantly improved for decades. An increased understanding of the molecular mechanisms of these cancers is needed for improvement in early diagnosis, enhanced treatment effectiveness, and cancer prevention. 4-nitroquinoline 1-oxide (4NQO) is a well-tested, tobacco mimicking, carcinogen. 4NQO produces similar histological and chemical changes found in human …

Teaching Children With Autism Spectrum Disorder Self-Protection Skills In Response To Bullying Situations, Maya J. Fallon

Theses & Dissertations

Children diagnosed with autism spectrum disorder (ASD) are at high risk of being bullied but research on teaching children with ASD self-protection skills for bullying situations is scant. We assessed the generality of teaching procedures used in Stannis et al. (2019) to teach adults self-protection skills with autistic children. We taught five children self-protection skills for two types of bullying (threats and unkind remarks) in a one-on-one format. In addition, we taught children a self-protection skill for repeated bullying occurrences. We first evaluated behavioral skills training to teach children to report threats of physical or material harm, provide a disapproving …

Empowering Lung Cancer Survivors In Post-Treatment Survivorship Care Using Participatory Action Research, Kelly Filchner

Electronic Theses and Dissertations

Purpose: To explore the experiences of lung cancer survivors (LCS) and their informal and professional caregivers with post-treatment care and to empower them to implement action-based study findings.

Participants & Setting: Participants were recruited using purposeful and snowball sampling from an NCI-designated cancer center in Northeastern US.

Methodological Approach: This study used a participatory action research (PAR) four-phase design. Phase one was a focused ethnography; phase two utilized a core group of participants to decide an action to be implemented in phase three; and phase four evaluated the action for the completion of one PAR cycle.

Findings: Twenty-eight categories, eight …

The Effects Of Active Shootings On 4-H Youth And Families, Melinda Garcia, Elizabeth Gangwer

Journal of Extension

The effects of active shootings should be a priority to provide needed assistance to 4-H youth and families in coping with their social-emotional well-being. Exposure to such violence can lead to lasting impacts on youth that can affect behavior. Addressing this sensitive topic is crucial in ensuring that Extension professionals are prepared to meet the needs of youth and families. Higher rates of depression, aggression, to name a few, are a result of having witnessed such events as a shooting. Providing training for Extension personnel can aid in reducing the amount of PTSD and other social-emotional trauma.

Curating The Agenda: A Review Of The Tenement Museum’S Twitter, Taylor Carpenter

Theses

Most museums have established strong online presences, due in part to the effects of the COVID-19 pandemic. To stay relevant in the social media sphere, museums must keep up with the speed at which the internet operates. One way of doing this is to follow the current trends and events that are already piquing the interest of those on the internet. However, is it the museum account that follows the current events, or are current events influenced by the museum’s presence? By examining the Tenement Museum’s Twitter account through the agenda-setting and agenda-melding theories, this paper seeks to answer the …

The Process Of Growing In Small Firms: Exploring Dialectic Adjustments To Nonroutine Disruption, Ivana Milosevic, A. Erin Bass, Mary Uhl-Bien

Management Faculty Publications

Studies examining small firm growth have suggested that growth is complex due to the multitude of internal and external factors that disrupt it. However, in focusing mainly on external factors and paying less attention to internal factors, the process of growing – or what is happening inside a small firm as it grows – remains undertheorized. Using findings from a real-time case study of a small firm and insights from the dialectical perspective, we develop a theoretical model that illustrates growth as a dynamic process occurring through dialectic adjustments in response to disruptions that cannot be resolved with routine practices. …

Addressing The Educational And Interventional Needs Of Wiskott Aldrich Syndrome (Was) Patients And Families, Naomi Tesfaiohannes

Master's Projects and Capstones

Wiskott Aldrich Syndrome (WAS) is an immune system (immunodeficiency) and blood disorder that increases the risk of severe infections and bleeding. A patient with WAS has a significant reduction in the size and number of platelets (micro thrombocytopenia), meaning there is a reduced ability to form blood clots and stop bleeding. WAS affects approximately 1 in 250,000 males in the United States. Public information on WAS is predominantly scientifically based, which makes it difficult for families to fully understand the syndrome, the impacts of severe bleedings on patients’ daily activity, and how to improve the patients’ quality of life. This …

My Shoulder Is On Backwards?! Reverse Total Shoulder Arthroplasty Vs Hemi- Arthroplasty In Complex Humeral Fractures Of Elderly, Kyle Wilson

Physician Assistant Capstones, 2020-current

No abstract provided.

Risking The Wrist, Tyler Mosier, Evan White

Physician Assistant Capstones, 2020-current

Abstract:

Background: Carpal tunnel syndrome (CTS) is now one of the most common workplace injuries, with nearly 50% of patients eventually requiring CTS release surgery as a permanent solution. With a concern of a younger incidence of CTS developing in a technology dependent society, some patients may fear even a minimal loss of function. To our knowledge there has been no study comparing forearm grip strength before symptoms develop to grip strength after the procedure has been performed.

Objectives: The aim of this study was to determine if there was a significant change in strength of the flexor digitorum superficialis …

Plantar Fasciitis: Steroids Or Prp?, Alexandra Lepecha, Grant Rankins

Physician Assistant Capstones, 2020-current

Abstract

Objective: The aim of this review is to compare the therapeutic effects of corticosteroids injections and platelet rich plasma therapy in the treatment for chronic plantar fasciitis that is refractory to conventional treatment options, using the Foot Function Index (FFI) score as an indicator of improvement

Design: Meta Analysis

Methods: A search of PubMed and CINAHL was performed in 2021 using the terms “‘plantar fasciitis’, and ‘prp or platelet rich plasma’ and ‘corticosteroids’ and ‘foot function index.’” Three articles were chosen to be included in qualitative synthesis.

Results: Studies from Peerbooms et al, Ugurlar et al, and Tabrizi et …

Injuries In Manual And Mechanical Cpr, Macon Spruill, Malik Bangura

Physician Assistant Capstones, 2020-current

Objective: To compare the rate of injuries during cardiopulmonary resuscitation (CPR) using manual versus mechanical chest compressions with the Lund University Cardiopulmonary Assist System (LUCAS™).

Design: Systematic literature review

Methods: We investigated the use of 2 different CPR methods, manual and mechanical, in order to determine if one was more likely to cause injury in individuals during a cardiac arrest. PubMed searches were conducted using the terms “cardiopulmonary resuscitation,” “adverse effect,” “classification,” “method,” “mortality,” “statistical and numerical data,” “trends,” “complication,” “epidemiology,” and “etiology.” Studies were excluded if they took place before the year 2000, included individuals under 18 …

Effect Of Mesenchymal Stem Cells On Osteoarthritis Of The Knee, Brendan Avery, Jessica Gray

Physician Assistant Capstones, 2020-current

Osteoarthritis of the knee is one the most common sources of chronic pain due to altered joint function.¹ Current treatment modalities offer short term relief of symptoms but lack long term aid and regenerative properties.¹ Mesenchymal stem cells (MSC) offer regenerative and anti-inflammatory properties and can be collected from umbilical cord blood, adipose tissue, or bone marrow.⁴ The three studies included were all randomized controlled trials within the past 10 years that each utilized more than 30 participants who had a diagnosis of osteoarthritis and a mean age above 50 years old. MSCs were compared to corticosteroid …

Use Of Long-Acting Injectable Cabotegravir And Rilpivirine In Hiv Maintenance Therapy, Andrea K. Ferrero, Nabil Naim

Physician Assistant Capstones, 2020-current

To determine if long-acting injectables cabotegravir and rilpivirine are non-inferior to oral antiretroviral therapy at maintaining viral load suppression below 50 copies per milliliter of serum. Design: Systematic literature review. Methods: A search was done in PubMed using the terms “HIV + cabotegravir” or “HIV + cabotegravir, rilpivirine drug combination.” Limitations included non-randomized control trials, comparison of injectable regimens directly or injectables to placebo, studies that evaluate compliance or side effects only, and studies with small sample sizes. Results: Meta-analysis revealed that continued use of injectables was sufficient in maintaining viral suppression at 93.6%, 92.5%, and 94% in each of …

The Use Of Kernig’S And Brudzinski’S Sign In Determining Meningitis: A Review, Crystal T. Duong, Ashton Hughes, Kerem Yilmaz

Physician Assistant Capstones, 2020-current

Objective: Assess the diagnostic value of Kernig’s and Brudzinski’s signs in determining meningitis among individuals aged 18 to 64. Design: Systematic literature review. Methods: Searches done in PubMed utilizing the terms Kernig and Brudzinski. In PubMed, studies were excluded if not in English, older than 2000 or done on animals, and meta-analyses. Results: Three studies were found including Nakao JH, et al, Thomas KE, et al, and Waghdhare S, et al. Conclusion: Kernig’s and Brudzinski’s signs have high specificity but yield a low sensitivity in determining meningitis. They are great tools to be utilized by medical providers, but only support …

Use Of Cardiomems Hf Sensor In Management Of Nyha Class Iii Heart Failure, Trevor Andrunik, Anne Eady

Physician Assistant Capstones, 2020-current

Objective: Assess the ability of continuous pulmonary artery pressure monitoring via implantable CardioMEMs HF device to reduce hospitalization in New York Heart Association (NYHA) Class III heart failure patients over the age of 18. Design: Systematic literature review. Methods: Searches were conducted via PubMed and ClinicalTrials.gov using the single search term “CardioMEMs.” Inclusion criteria narrowed results to studies performed in the last 10 years, randomized control trials, cohort studies, and utilizing heart failure related hospitalization as the primary endpoint. Results: The current data unanimously asserts that the CardioMEMs HF device is effective at reducing heart failure related hospitalizations, with secondary …

Counselor Educator's Perspective On Clinical Supervision Interventions For International Counseling Students, Ah Ram Lee

Dissertations - ALL

The present study employed Q methodology to answer the research question of what the shared subjective understanding of counselor educators (CEs) is about what necessary clinical supervision interventions are for the professional development of international counseling students (ICSs). Based on the review of current clinical supervision literature, the researcher created a Q sort that addresses what ICSs believe as helpful or could have been helpful supervision interventions on improving their professional development. The 32 CEs who participated in the present study ranked the 38 items on the Q sort based on their subjective understanding of the most and least necessary …

Powers And The Metaphysics Of Fundamentality, Benjamin Cook

Dissertations - ALL

In this dissertation, I address the question of whether ground, the relation that obtains between entities e1...en and a further entity e when e ontologically depends on, and is metaphysically explained by, e1...en, should be understood causally and, if so, whether this has any substantive implications. I answer both in the affirmative. I argue that ground and causation are similar enough to motivate characterizing ground as a special kind of causation, and that this can be done if we adopt a powers-theoretic account of causation. Moreover, I argue that the resultant view of ground, what I call “powerful, existential causation,” …

Assessing The Mental Health Of Women At The Intersection Of Intimate Partner Violence And Animal Cruelty: Personal And Population Level Risk Factors For Co-Victimization, Alaina M. Beauchamp

Dissertations and Theses (Open Access)

One predictor of intimate partner violence (IPV) occurring in the home is pet abuse. The high prevalence of pet cruelty among IPV relationship can create a significant barrier to seeking help due to the inability to bring the pet or concern for the pet’s wellbeing. This human-animal bond is a more common source of emotional support among victims with experiences of pet abuse, as opposed to women whose pets had not been abused. This study 1) explored the relationship between victims of IPV and their pets, the dynamics and characteristics of situations of co-victimization (i.e., abuse of both a human …

Penalty Default Rules In Quebec Contract Law, Zackary Goldford

Journal of Civil Law Studies

Few would deny that contract law is filled with default rules, but there has been a great deal of scholarly debate about their purposes and functions. Some American scholars have argued that there are default rules that do not align with most parties’ expectations; indeed, they impose a burden on one or both parties if they are not departed from. Departing from these default rules typically requires one or both parties to share information that they might have otherwise kept to themselves. These have been called “penalty default rules.” While there is a significant amount of scholarship on penalty default …

An Essay On Ideology And Legal Education In Micro Jurisdictions: The Example Of Jersey, David Marrani

Journal of Civil Law Studies

This article explores the question of legal education in micro jurisdictions using the case of Jersey, a British Crown Dependency, positioned geographically, historically and culturally between two larger jurisdictions, France and the UK. It analyses how Jersey’s legal training is pulled towards those large “big neighbours,” rather than focusing on what makes its specificity and attraction. It questions how legal education in micro-jurisdiction is actually linked to ideology. The article starts with the following question: are we taking micro jurisdictions seriously? It then considers the routes to legal qualification in micro jurisdictions, before focusing specifically on the case of Jersey …

Cole V. Thomas, Macy P. Spencer

Journal of Civil Law Studies

No abstract provided.

Complete V.14

Journal of Civil Law Studies

No abstract provided.

Conversations About Book Challenges And Bans: Civil Discourse Through Talking Frames And Sentence Stems, Alonna Lynn Liabenow

Masters Projects

Book challenges and bans are more prevalent than ever in the year 2022. The conversations surrounding the challenge of a book are often very stressful for the librarian, teacher, or administrator involved. This project seeks to ease some of that stress by giving the parties involved in conversation a talking frame. These talking frames are based on the norms of civil discourse and make use of sentence stems to guide potentially tense and awkward conversations.

Difficult Intravenous Access In Pediatrics: Improving First Attempt Success Rates, Daisy G. Portier

Master's Projects and Capstones

Abstract

Problem: This project aims to improve the success rate of peripheral intravenous catheter insertion on the first attempt from 50% to 60% with the implementation of the Difficult Intravenous Access (DIVA) clinical assessment and escalation tool, developed by the Queensland Children’s Hospital of Australia.

Context:[LB1] Inserting a peripheral intravenous catheter is the most common invasive procedure during hospitalization. Obtaining vascular access in children may require multiple attempts due to their anatomical variations, smaller caliber veins, and the child's level of anxiety. Up to 69% of first-attempt insertions fail, leading to delays in medical treatment and extended hospitalizations. Early …

An Implementation Roadmap For Establishing Remote Infectious Disease Specialist Support For Consultation And Antibiotic Stewardship In Resource-Limited Settings, Robin L.P. Jump

Faculty Scholarship

Infectious Disease (ID)-trained specialists, defined as ID pharmacists and ID physicians, improve hospital care by providing consultations to patients with complicated infections and by leading programs that monitor and improve antibiotic prescribing. However, many hospitals and nursing homes lack access to ID specialists. Telehealth is an effective tool to deliver ID specialist expertise to resource-limited settings. Telehealth services are most useful when they are adapted to meet the needs and resources of the local setting. In this step-by-step guide, we describe how a tailored telehealth program can be implemented to provide remote ID specialist support for direct patient consultation and …

Both Businesses And Local Governments Could Benefit From Improvements To Tennessee's Personal Property Tax, Tennessee. Advisory Commission On Intergovernmental Relations.

Taxes Reports

No abstract provided.

Exploring The Influence Of Contextual Factors And The Caregiving Process On Burden, Quality Of Life, And Outcomes Of Heart Failure (Hf) Dyads After A Hospital Discharge Guided By The Individual And Family Self-Management Theory (Ifsmt): A Mixed Method Study, Tamara Bernard

Theses & Dissertations

ABSTRACT The purpose of this study is to explore the influence of contextual factors and caregiving process characteristics on proximal outcomes of the patient and caregiver after discharge from the hospital. The long-term goal of this research is to reduce caregiver burden and improve patient outcomes. Heart failure (HF) is an increasingly common chronic illness with unique caregiving needs and a high rate of hospital readmissions. Caregiver burden has been researched extensively in other areas of medicine such as oncology and dementia and has been reported for stable chronic HF patients in an outpatient setting. However, there is little research …

The Role Of Parkin In Mitochondrial Dna, Eliezer Lichter

Theses & Dissertations

Mitochondria are at the center of biological phenomena such as aging and diseases, especially neurodegenerative diseases. While the discovery of mitochondria only came approximately 200 years after the cell was discovered, a lot of progress has been made since. The mitochondrial genome encodes proteins vital for mitochondrial function. These proteins are only a subset of the proteins present in mitochondria; the rest are nuclear encoded. The nucleus also encodes cytosolic proteins vital for mitochondrial maintenance. One of these is Parkin, an E3 ubiquitin ligase that ubiquitinates mitochondrial proteins as mitochondria become depolarized. Its activity has been shown to be involved …

Chemical Elements, Flavor Chemicals, And Nicotine In Unused And Used Electronic Cigarettes Aged 5–10 Years And Effects Of Ph, Monique Williams, Wentai Luo, Kevin J. Mcwhirter, Omeka Ikegbu, Prue Talbot

Chemistry Faculty Publications and Presentations

The concentrations of elements/metals, nicotine, flavor chemicals and acids were compared in the e-liquids of unused and used first-generation electronic cigarettes (ECs) that were stored for 5–10 years. Metal analysis was performed using inductively coupled plasma optical emission spectroscopy; nicotine and flavor chemical analyses were performed using gas chromatography/mass spectroscopy. Of the 22 elements analyzed, 10 (aluminum, chromium, copper, iron, lead, nickel, selenium, silicon, tin, zinc) were often found in the e-liquids. Five elements had the highest average concentrations: copper (1161.6 mg/L), zinc (295.8 mg/L), tin (287.6 mg/L), nickel (71.1 mg/L), and lead (50.3 mg/L). Nicotine concentrations were always lower …

Use Of Library Information Resources By Undergraduate Students At Sokoine University Of Agriculture, Tanzania, Nicholaus Mwalukasa Dr

Library Philosophy and Practice (e-journal)

The study examines use of library information resources by students of Sokoine University of Agriculture in Tanzania. The study employed cross-sectional research. Systematic sampling was to select 120 respondents. Data was collected using structured questionnaire. Quantitative data was coded and analyzed using the statistical package for social science (SPSS). Frequency and percentages was analyzed. The results found that most of the respondents mainly used special collection, general collection and special reserve. The study further found that e journal and e-book were the most accessed and utilized e resources, while dissertation was the least used e resources. The study also revealed …