Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network

Open Access. Powered by Scholars. Published by Universities.®

2022

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 32011 - 32040 of 32198

Full-Text Articles in Entire DC Network

The Effect Of Platelet-Rich Plasma And Hyaluronic Acid Nanogel On Wound Healing In Rat Skin Models, Pirada Virankabutra Jan 2022

The Effect Of Platelet-Rich Plasma And Hyaluronic Acid Nanogel On Wound Healing In Rat Skin Models, Pirada Virankabutra

Chulalongkorn University Theses and Dissertations (Chula ETD)

The study aimed to validate two-step procedure PRP protocol and assess the effect on skin healing process in rats treated with PRP and/or HA nanogel. A total of 46 Wistar rats were enrolled in the study. PRPwas produced and its hematological parameters were examined. Six skin defects were created and topicals (control, PRP, HA, PRP/HA, PRP/HA cream, and cream) were applied to the wounds. The progression of wound reduction was photographed daily, and calcutated to wound area. Skin samples were collected according to sampling timepoints: day 0, 3, 7,10, and 14, and stained for histological grading. The platelet (2457.15 $ …


การเมืองเรื่อง “ครอบครัว” ในประเทศไทยจากสมัยสมบูรณาญาสิทธิราชย์ถึงยุคพัฒนา (พ.ศ. 2456–2519), สุรเชษ์ฐ สุขลาภกิจ Jan 2022

การเมืองเรื่อง “ครอบครัว” ในประเทศไทยจากสมัยสมบูรณาญาสิทธิราชย์ถึงยุคพัฒนา (พ.ศ. 2456–2519), สุรเชษ์ฐ สุขลาภกิจ

Chulalongkorn University Theses and Dissertations (Chula ETD)

หน่วยความสัมพันธ์ที่เรียกว่า “ครอบครัว” ถูกนิยามขึ้นอย่างเป็นทางการและกลายเป็นองค์ประกอบพื้นฐานของรัฐไทยนับตั้งแต่พระบาทสมเด็จพระมงกุฎเกล้าเจ้าอยู่หัวทรงบัญญัติกฎหมายนามสกุลขึ้นใน พ.ศ. 2456 วิทยานิพนธ์นี้เลือกศึกษาประวัติศาสตร์การเมืองเรื่องครอบครัว ซึ่งเป็นประเด็นที่งานศึกษาก่อนหน้านี้ให้ความสนใจไม่มากนัก โดยมุ่งเน้นไปที่กระบวนการก่อรูปของรัฐในทางเพศสภาพนับตั้งแต่การนิยามครอบครัวขึ้นในสมัยสมบูรณาญาสิทธิราชย์เรื่อยมาจนถึงการแก้ไขกฎหมายครอบครัวในยุคพัฒนา ประเด็นสำคัญที่วิทยานิพนธ์มุ่งพิจารณา ได้แก่ ครอบครัวสัมพันธ์กับการเมืองไทยอย่างไร รัฐพยายามกำหนดปฏิสัมพันธ์ในครอบครัวอย่างไร และกฎหมายครอบครัวถูกต่อรองอย่างไร โดยสำรวจจากโครงการต่างๆ ของรัฐ เช่น การอุปมากษัตริย์ให้เป็นพ่อ การนิยามครอบครัวให้เป็นหน่วยย่อยของชาติ การตราและแก้ไขกฎหมายครอบครัว การสร้างชาติในทางวัฒนธรรม การสงเคราะห์ครอบครัว การร่างรัฐธรรมนูญ กิจการต่างประเทศ และการพัฒนาครอบครัว วิทยานิพนธ์นี้เสนอว่าครอบครัวคือศูนย์กลางหนึ่งของการเมืองไทยสมัยใหม่ สำหรับสมบูรณาญาสิทธิราชย์ การเมืองเรื่องครอบครัวยึดโยงอยู่กับการอุปมากษัตริย์ให้เป็นพ่อผู้ปกครองชาติ ขณะที่การเมืองเรื่องครอบครัวหลังการปฏิวัติ พ.ศ. 2475 ยืนพื้นอยู่ที่การรณรงค์สร้างชาติโดยเฉพาะในทางวัฒนธรรมด้วยการมอบบทบาทให้ผู้ชายเป็นหัวหน้าครอบครัวและให้ผู้หญิงเป็นเมียและแม่ ต่อมาในช่วงหลังสงครามโลกครั้งที่สอง การเมืองเรื่องครอบครัวยังเคลื่อนออกไปสัมพันธ์กับการแสวงหาสถานะของไทยในเวทีนานาชาติด้วย อย่างไรก็ดี รัฐไม่ได้ดำรงอยู่อย่างเบ็ดเสร็จเด็ดขาดและถูกท้าทายจากสังคมในยุคพัฒนาที่กระแสสิทธิสตรีกำลังขยายตัวอย่างมาก นำไปสู่การแก้ไขเคลื่อนไหวเรียกร้องให้แก้ไขกฎหมายครอบครัวเพื่อลดอำนาจในครอบครัวของผู้ชายลงให้สอดคล้องกับหลักสากลของความเสมอภาคทางเพศ ซึ่งประสบผลสำเร็จใน พ.ศ. 2519


The Monetization Of Childhood: How Child Social Media Stars Are Unprotected From Exploitation In The United States, Jessica Pacht-Friedman Jan 2022

The Monetization Of Childhood: How Child Social Media Stars Are Unprotected From Exploitation In The United States, Jessica Pacht-Friedman

Cardozo Journal of Equal Rights & Social Justice

The note highlights the legal vulnerabilities of child social media influencers, or "kidfluencers," who are increasingly exploited due to inadequate protections under U.S. labor laws. The Fair Labor Standards Act (FLSA) exempts child performers, and while some states have Coogan Laws, these are insufficient to address the unique challenges posed by digital platforms like YouTube. The author advocates for expanding these protections to include social media stars and adopting a "Right to be Forgotten" to safeguard children's privacy and financial interests.


Equal Education Means Equal Education: Confronting Education Access Disparities For New York Students Amid The Covid-19 Pandemic During The 2020-2021 School Year, Sara Gruber Jan 2022

Equal Education Means Equal Education: Confronting Education Access Disparities For New York Students Amid The Covid-19 Pandemic During The 2020-2021 School Year, Sara Gruber

Cardozo Journal of Equal Rights & Social Justice

The COVID-19 pandemic exacerbated existing educational disparities, particularly affecting low-income and minority students in New York due to the shift to online learning. The state's current legislation, such as the Dignity for All Students Act, fails to address these off-campus digital divide issues, necessitating legal reform to ensure equal educational opportunities.


The British Government's Continued Failure To Deal With Deaths Resulting From The Troubles In Northern Ireland Is A Violation Of Human Rights, Marie Simpson Jan 2022

The British Government's Continued Failure To Deal With Deaths Resulting From The Troubles In Northern Ireland Is A Violation Of Human Rights, Marie Simpson

Cardozo Journal of Equal Rights & Social Justice

The note argues that the British government's failure to adequately investigate and address the 3,000 unsolved murders from the Troubles in Northern Ireland constitutes a violation of human rights. It critiques the government's proposed Historical Investigations Unit for being insufficient and not meeting the procedural standards required by Article 2 of the European Convention on Human Rights. The note proposes a restructured unit to ensure impartial and effective investigations, emphasizing the need for accountability and closure for victims' families.


Corporate Capital & Legal Personality: A Marxist Account Of Citizens United Ten Years Later, Hayden E. Pendergrass Jan 2022

Corporate Capital & Legal Personality: A Marxist Account Of Citizens United Ten Years Later, Hayden E. Pendergrass

Cardozo Journal of Equal Rights & Social Justice

The article presents a Marxist critique of the Citizens United decision, arguing that it embodies the dominant capitalist ideology by granting corporations extensive First Amendment rights. This decision reflects the legal system's role in reinforcing corporate power and control over the political process, aligning with Marxist theories of law as a tool of class domination.


Artificial Intelligence: The Impact It Has On American Society, Peggy J. Anderson Jan 2022

Artificial Intelligence: The Impact It Has On American Society, Peggy J. Anderson

All Student Theses and Dissertations

The goal of this paper seeks to look at Artificial Intelligence (AI) influences and impacts on society in the United States. It focuses on the challenges and opportunities of AI, the current state of AI, where AI may advance to in the future, how far AI will go and the way people view it, the positive impact of AI on society, and the breakdown of nine ethical issues in artificial intelligence.


Zero Trust Architecture, Ahmed Abdullah Syed Jan 2022

Zero Trust Architecture, Ahmed Abdullah Syed

All Student Theses and Dissertations

Cyber threats are becoming increasingly sophisticated, and IT organizations need to continue to modernize their approaches to cybersecurity in light of today's dynamic cyber threat environment. Cybersecurity professionals must adopt a zero-trust security model and the mindset needed to engineer and operate a system specifically designed to operate according to zero trust principles in order to ensure the security of sensitive data, systems, and services as enterprise networks become increasingly dispersed and complex.


Demographics, Strategies, Coursework, And Field Experiences On The Perceptions Of Preparedness Of Early Childhood Teachers To Teach Black Boys In Pre-K Through 3rd Grade Classrooms: The Impact, Kimberly S. Peterz Jan 2022

Demographics, Strategies, Coursework, And Field Experiences On The Perceptions Of Preparedness Of Early Childhood Teachers To Teach Black Boys In Pre-K Through 3rd Grade Classrooms: The Impact, Kimberly S. Peterz

All Student Theses and Dissertations

This quantitative cross-sectional study examined the perceptions of preparedness of early childhood teachers to teach Black boys in Pre-K through 3rd grade classrooms. The purpose of this study was to understand if perceptions of preparedness of early childhood teachers differed based on age, race, location of teacher preparation program, and current teaching location. This study focused on specific demographics such as age and race from an anonymous sample of early childhood teachers (N=50) in the United States. Additionally, educational and professional characteristics such as location of teacher preparation institution and current teaching location were utilized. The personal, educational, and professional …


The Other Bar Hurdle: An Examination Of The Character And Fitness Requirement For Bar Admission, David L. Hudson Jr., Andrea Gemignani Jan 2022

The Other Bar Hurdle: An Examination Of The Character And Fitness Requirement For Bar Admission, David L. Hudson Jr., Andrea Gemignani

Law Faculty Scholarship

In The Other Bar Hurdle, published in the Mitchell Hamline Law Review, the authors examine the character and fitness requirement as a critical yet under-scrutinized component of attorney licensing. The Article surveys the historical foundations, purposes, and contemporary administration of character and fitness investigations, highlighting their dual aims of protecting the public and safeguarding the integrity of the courts. It then synthesizes extensive scholarly criticism, focusing on concerns about discriminatory origins, lack of transparency, inconsistent application, deterrent effects on prospective applicants, and the disproportionate impact on individuals with criminal records, financial hardship, or mental health histories. While acknowledging …


Essay: A Continuing Constitutional Trend Of Using The First To Interpret The Second, David L. Hudson Jr. Jan 2022

Essay: A Continuing Constitutional Trend Of Using The First To Interpret The Second, David L. Hudson Jr.

Law Faculty Scholarship

This Essay examines the continuing constitutional trend of using First Amendment principles to interpret and develop Second Amendment doctrine. Beginning with District of Columbia v. Heller, in which the Supreme Court drew multiple analogies between the two amendments, the article traces how lower courts have relied on First Amendment jurisprudence to structure Second Amendment analysis. Courts have borrowed concepts such as the non-absolute nature of constitutional rights, the role of history and tradition, categorical exclusions, tiered standards of scrutiny, adequate alternatives, evidentiary requirements, and doctrines relating to fees, underinclusivity, and geographic limitations. At the same time, courts have rejected …


Whiteness As Contract, Marissa Jackson Sow Jan 2022

Whiteness As Contract, Marissa Jackson Sow

Law Faculty Publications

2020 forced scholars, policymakers, and activists alike to grapple with the impact of “twin pandemics”—the COVID-19 pandemic, which has devastated Black and Indigenous communities, and the scourge of structural and physical state violence against those same communities—on American society. As atrocious acts of anti-Black violence and harassment by law enforcement officers and white civilians are captured on recording devices, the gap between Black people’s human and civil rights and their living conditions has become readily  apparent. Less visible human rights abuses camouflaged as private commercial matters, and thus out of the reach of the state, are also increasingly exposed as …


The Emergence Of Neutrality, Jud Campbell Jan 2022

The Emergence Of Neutrality, Jud Campbell

Law Faculty Publications

This Article traces two interwoven jurisprudential genealogies. The first of these focuses on the emergence of neutrality in speech and press doctrine. Content and viewpoint neutrality are now the bedrock principles of modern First Amendment law. Yet the history of these concepts is largely untold and otherwise misunderstood. Scholars usually assume that expressive-freedom doctrine was mostly undeveloped before the early twentieth century and that neutrality was central to its modern rebirth. But this view distorts and sometimes even inverts historical perspectives. For most of American history, the governing paradigm of expressive freedom was one of limited toleration, focused on protecting …


The Banker Removal Power, Da Lin Jan 2022

The Banker Removal Power, Da Lin

Law Faculty Publications

The Federal Reserve (“the Fed”) can remove bankers from office if they violate the law, engage in unsafe or unsound practices, or breach their fiduciary duties. The Fed, however, has used this power so rarely that few even realize it exists. Although major U.S. banks have admitted to repeated and flagrant lawbreaking in recent years, the Fed has never removed a senior executive from one of these institutions.

This Article offers the first comprehensive account of the banker removal power. It makes four contributions. First, drawing on a range of primary sources, it recovers the power’s statutory foundations, showing that …


How Biden Could Keep Filling The Federal Circuit Court Vacancies, Carl Tobias Jan 2022

How Biden Could Keep Filling The Federal Circuit Court Vacancies, Carl Tobias

Law Faculty Publications

In October 2020, Democratic presidential nominee Joe Biden speculated that the fifty-four talented, extremely conservative, and exceptionally young, appellate court judges whom then-President Donald Trump and two relatively similar Grand Old Party (GOP) Senate majorities appointed had left the federal appeals courts “out of whack.” Problematic were the many deleterious ways in which Trump and both of the upper chamber majorities in the 115th and 116th Senate undermined the courts of appeals, which are the courts of last resort for practically all lawsuits, because the United States Supreme Court hears so few appeals. The nomination and confirmation processes which Trump …


The Promise And Perils Of Private Enforcement, Luke Norris Jan 2022

The Promise And Perils Of Private Enforcement, Luke Norris

Law Faculty Publications

A new crop of private enforcement suits is sprouting up across the country. These laws permit people to bring enforcement actions against those who aid or induce abortions, against schools that permit transgender students to use bathrooms consistent with their gender identities, and against schools that permit transgender students to play on sports teams consistent with their gender identities. Similar laws permit people to bring enforcement actions against schools that teach critical race theory and against those who sell restricted firearms. State legislatures are considering a host of laws modeled on these examples, along with other novel regimes. These are …


Policy Implications Of Urban Greening To Sustainable Gentrification: A Case Study Of Quezon City, Philippines, Joachim James De Castro Jan 2022

Policy Implications Of Urban Greening To Sustainable Gentrification: A Case Study Of Quezon City, Philippines, Joachim James De Castro

Chulalongkorn University Theses and Dissertations (Chula ETD)

Rapid urbanization entails a number of urban problems that need to be confronted. There is a call to utilize urban spaces while observing the pillars of sustainability wherein the harmony among aspects such as economic, social, and environmental must be achieved. Urban greening, a tool for urban planning is one of the solutions being seen by different stakeholders globally in addressing urban problems. However, in the process of urban development, gentrification, an unchecked phenomenon arises. The movement of middle class people to either developed or redeveloped urban areas can possibly entail social issues such as displacement and exclusivity of urban …


Critical Success Factors For Digital Transformation Implementation In The Construction Industry: An Integrated Fuzzy Cognitive Map And Ranking Analysis Approach, Tan Thanh Trang Jan 2022

Critical Success Factors For Digital Transformation Implementation In The Construction Industry: An Integrated Fuzzy Cognitive Map And Ranking Analysis Approach, Tan Thanh Trang

Chulalongkorn University Theses and Dissertations (Chula ETD)

The process of digital transformation (DX) involves the systematic integration of digital technologies, processes, and skills at all levels and functions within an organization, industry, or ecosystem. The emergence and rapid spread of the coronavirus are accelerating DX in all industies and the construction industry is not an exception. Construction companies are on the verge of significant transformation driven by advancements and the adoption of digital technologies. However, knowledge and information about how to implement DX efficiently in construction firms are fragmented and limited. This leads to the failure of DX journey of the majority of construction firms. This research …


How Flash Manufacturing Pmi Is Affecting The U.S. Stock Market. An Empirical Study, Thurein Htet Myat Jan 2022

How Flash Manufacturing Pmi Is Affecting The U.S. Stock Market. An Empirical Study, Thurein Htet Myat

Chulalongkorn University Theses and Dissertations (Chula ETD)

This paper presents a comprehensive analysis of the relationship between the US Flash Manufacturing PMI news releases, returns, and volatilities of Russell 1000 and 2000 indexes. Using an autoregressive (AR) and generalized autoregressive conditional heteroskedasticity (GARCH) model, the study examines data from January 2015 to November 2022, encompassing both pre-pandemic, pandemic, and post-pandemic periods. The statistical analysis indicates that these news releases do not significantly influence stock returns, supporting the efficient market hypothesis. Various factors, including measurement errors and the unique circumstances of the Covid-19 pandemic, likely overshadowed the impact of PMI news releases. Additionally, the analysis finds no significant …


Global Oil Price Transmission To Domestic Diesel Prices, Andthe Impact On Listed Firm's Profitability And Stock Market Returns : Evidence From Thailand, Koravik Renuros Jan 2022

Global Oil Price Transmission To Domestic Diesel Prices, Andthe Impact On Listed Firm's Profitability And Stock Market Returns : Evidence From Thailand, Koravik Renuros

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research paper provides a comprehensive analysis of the dynamics of volatile oil prices over the past two decades, with a focus on the stock exchange of Thailand from the period of 2004 to 2022. Firstly, the study utilizes the Vector Autoregressive Model (VAR) technique to examine the impact of global oil price fluctuations on domestic fuel prices and the stock market in Thailand. The findings reveal that changes in global oil prices have a delayed and indirect effect on the Thai stock market. The transmission of volatility through domestic diesel prices is a crucial factor in this relationship. Notably, …


Is Greener Really Better? Stock Market Reaction To Green Bond Announcements, Evidence From Europe, Niya Somkerd Jan 2022

Is Greener Really Better? Stock Market Reaction To Green Bond Announcements, Evidence From Europe, Niya Somkerd

Chulalongkorn University Theses and Dissertations (Chula ETD)

Employing an event-study approach, we examine how the stock market responded to the offering of green bonds by non-financial companies listed on the European stock market from January 2013 to September 2022. We observed a drop, on average about 0.28%, in the company stock prices on the day they announced these offerings and the day after. Moreover, we found that investors react in the same manner for green bond announcements as for conventional bond announcements. We also studied if the Gavriilidis (2021)'s climate policy uncertainty index has any relationship with the market reactions. Our findings suggest that the index is …


An Exploratory Study Of Online Socialising And Hiv-Related High-Risk Sexual Behavior Among University Students In Chengdu, People’ S Republic Of China, Qin Bo Jan 2022

An Exploratory Study Of Online Socialising And Hiv-Related High-Risk Sexual Behavior Among University Students In Chengdu, People’ S Republic Of China, Qin Bo

Chulalongkorn University Theses and Dissertations (Chula ETD)

Young students in China have emerged as a high-risk demographic for HIV infection. Recent research findings confirm that engaging in unprotected sex with multiple partners remains the primary contributor to HIV transmission. However, in light of the ever-evolving landscape of network socialization and the deepening comprehension of HIV among young students, their attitudes and behaviors towards the virus have exhibited distinct characteristics. This study focuses on university and college students in Chengdu as the target population, aiming to comprehensively comprehend the present state and distinctive patterns of their sexual conduct, particularly high-risk sexual behavior. Moreover, it investigates the influence of …


Fptp Electoral System Of Myanmar As A Barrier For Ethnic Minority Inclusiveness In Parliamentary Decision-Making, Yamonh Pwint Thit Jan 2022

Fptp Electoral System Of Myanmar As A Barrier For Ethnic Minority Inclusiveness In Parliamentary Decision-Making, Yamonh Pwint Thit

Chulalongkorn University Theses and Dissertations (Chula ETD)

In Myanmar, the ethnic minority do not have equal access to public services to raise their issues and voices for it. They are not adequately represented in state institutions by the political system which does not grant the adequate opportunities to participate in decision-making at union level. Ethnic minorities believe that all groups should have equal access to public services and enjoy an efficient system of protection of human rights. Ethnic Diversity may result in tensions within the nation when one group is economically or socially or politically dominant or privileged. By being discriminated and marginalized through the political system, …


The Effect Of Ict Infrastructure On Inward Fdi In Apec Countries, Nyi La Min Jan 2022

The Effect Of Ict Infrastructure On Inward Fdi In Apec Countries, Nyi La Min

Chulalongkorn University Theses and Dissertations (Chula ETD)

The objective of this study is to examine the effect of information and communication technology (ICT) infrastructure on inward foreign direct investment (FDI) in the Asia-Pacific Economic Cooperation (APEC) region by using panel data from 20 APEC economies over the 2005-2020 period. Various indicators of ICT-related factors, including number fixed telephone subscriptions, mobile cellular subscriptions, broadband subscriptions, and internet users have been used to measure the level of ICT infrastructure development. Principal component analysis (PCA) method is used to transform four indicators of ICT infrastructure together into an ICT infrastructure index. The study uses fixed-effects model to investigate the effect …


Automatic Image-Based Sbfe Approach For Multiphase-Materials Topology Optimization Under Dynamic Loading, Rut Su Jan 2022

Automatic Image-Based Sbfe Approach For Multiphase-Materials Topology Optimization Under Dynamic Loading, Rut Su

Chulalongkorn University Theses and Dissertations (Chula ETD)

This thesis presents the efficient topology optimization methods constructed within the state-of-the-art polygon scaled boundary finite element (SBFE) framework. The SBFE approach enables the discrete model construction of structures comprising of arbitrary curve geometry lying in 2D and/or 3D spaces. More explicitly, incorporated with quadtree (in 2D) and octree (3D) mesh refinements the automatic adaptive mesh scheme run within the polygon SBFE framework provides the cost-effective model generation allowing hanging nodes. These distinctive features present the developed SBFE approach well suiting as an underlying modeling framework for the topology design optimization of solids. The bi-directional evolutionary structural optimization (BESO) algorithm …


Royal Thai Army’S Role In De-Escalating The Thai-Cambodian Border Dispute: A Case Study Of Suranaree Command (2012-2022), Phromnachanok Ketphan Jan 2022

Royal Thai Army’S Role In De-Escalating The Thai-Cambodian Border Dispute: A Case Study Of Suranaree Command (2012-2022), Phromnachanok Ketphan

Chulalongkorn University Theses and Dissertations (Chula ETD)

As witnessed from 2008 to 2011 in the case of the Preah Vihear temple, boundary demarcation can become securitized and lead to armed clashes. The Royal Thai Army of the Kingdom of Thailand is primarily responsible for securing the land border. Along the Thai-Cambodian border, security threats still exist. Therefore, this paper aims to analyze how the Suranaree Command, one of the RTA’s border defense units, has performed its de-escalation efforts on the contentious Thai-Cambodian border. Using anonymous interviews and open-source information due to the confidentiality of the unit, this research investigates the Command’s performance from 2012-2022, along with other …


Challenges In Establishing An Asean Peacekeeping Force, Thanaphat Diewvilai Jan 2022

Challenges In Establishing An Asean Peacekeeping Force, Thanaphat Diewvilai

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research consults with the "norm’s life cycle" under international norm dynamics concept to identify and analyze the challenges in establishing an ASEAN Peacekeeping Force. This study argues that the emergent norm of establishing an ASEAN Peacekeeping Force has not yet reached the threshold to transition into the second stage of norm cascade where it is widely embraced by ASEAN member states; and the norm has not reached the stage of norm internalization where it is accepted within the practices of ASEAN. The presence of long-standing and powerful norms within the "ASEAN Way" hinders the advancement and full integration of …


Russian Motives In Cyberattacks: Case Studies Of Estonia And Ukraine, Theeratiphong Pannil Jan 2022

Russian Motives In Cyberattacks: Case Studies Of Estonia And Ukraine, Theeratiphong Pannil

Chulalongkorn University Theses and Dissertations (Chula ETD)

The purpose of this independent_study is to examine Russian motivations for the 2007 cyberattacks on Estonia's critical information infrastructure and the 2015 Ukraine power grid breach. It also analyzes the aftermath and consequences of the attacks, as well as efforts to address the issues. The study found that Russia's primary purpose in cyberattacks is most likely to survive the anarchy of the international system, in which states can never trust each other and must rely on themselves. The acts of Estonia and Ukraine, as well as NATO's ambitions to expand, intervene, and achieve dominance in Russia's sphere of influence, would …


Analysis Of Genetic Diversity In A Novel Vaccine Candidate, The Glutamic Acid-Rich Protein Of Plasmodium Falciparum (Pfgarp), Rattanaporn Rojrung Jan 2022

Analysis Of Genetic Diversity In A Novel Vaccine Candidate, The Glutamic Acid-Rich Protein Of Plasmodium Falciparum (Pfgarp), Rattanaporn Rojrung

Chulalongkorn University Theses and Dissertations (Chula ETD)

Malaria vaccine development confronts high genetic polymorphism in some antigenic components of the vaccine candidates, which could potentially limit the vaccine efficacy. An antigen of Plasmodium falciparum, designated glutamic acid-rich protein (PfGARP), has recently been considered as a strong vaccine target against asexual-blood-stages parasite. It has been shown that naturally acquired anti-PfGARP antibodies elicited clinical protection against severe malaria among people living in hyperendemic areas. Furthermore, PfGARP has been involved in binding to human erythrocyte band 3, which induces erythrocyte aggregation and might bring about severe malaria. However, the extent of genetic variation in the pfgarp locus among field isolates …


Development Of Plant-Produced Anti-Il-6r Mab, Namthip Kaewbandit Jan 2022

Development Of Plant-Produced Anti-Il-6r Mab, Namthip Kaewbandit

Chulalongkorn University Theses and Dissertations (Chula ETD)

After the body is invaded by pathogens, it responds by secreting cytokines, for example, interleukin 6 (IL-6), which activates an intracellular signaling pathway involving JAKs/STAT3 through phosphorylation. However, overexpression of pSTAT-3 can lead to a positive feedback loop of IL-6, causing the release of more cytokines and potentially leading to cytokine storm. Thus, inhibition of IL-6 signaling is another important target for Cytokine storm treatment. Tocilizumab, a humanized IL-6R antibody has been approved for RA treatment. There are several concerns about mammalian cell protein expression systems, such as higher production costs and pathogen contamination risks. Recently, plants have become increasingly …