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Articles 32011 - 32040 of 32369
Full-Text Articles in Entire DC Network
Protumorigenic Effects Of Mixed Lineage Kinase Domain-Like Protein In Cholangiocarcinoma Cells, Nattaya Duangthim
Protumorigenic Effects Of Mixed Lineage Kinase Domain-Like Protein In Cholangiocarcinoma Cells, Nattaya Duangthim
Chulalongkorn University Theses and Dissertations (Chula ETD)
Cholangiocarcinoma (CCA), a heterogeneous malignancy of bile duct system, has the highest incidence in Thailand. CCA is one of the leading causes of death which has low 5-year survival rate from 5% to 10% in advanced stages due to the difficulty of diagnosis in early stage and lack of effective therapies. Therefore, understanding the molecular mechanisms and pathogenesis of CCA development and progression is urgently needs and will lead to the development of novel therapeutic targets and strategies. Mixed lineage kinase domain-like (MLKL) was identified as a key effector in a novel regulated necrosis or necroptosis pathway. Recently studies have …
Validity Of Small-Scale Yielding Regime In Notched-Cracked Geometries, Mf Borges, Fv Antunes, Dm Neto, Jm Vasco-Olmo, Fa Díaz, Mn James
Validity Of Small-Scale Yielding Regime In Notched-Cracked Geometries, Mf Borges, Fv Antunes, Dm Neto, Jm Vasco-Olmo, Fa Díaz, Mn James
School of Engineering, Computing and Mathematics
No abstract provided.
Policy Implications Of Urban Greening To Sustainable Gentrification: A Case Study Of Quezon City, Philippines, Joachim James De Castro
Policy Implications Of Urban Greening To Sustainable Gentrification: A Case Study Of Quezon City, Philippines, Joachim James De Castro
Chulalongkorn University Theses and Dissertations (Chula ETD)
Rapid urbanization entails a number of urban problems that need to be confronted. There is a call to utilize urban spaces while observing the pillars of sustainability wherein the harmony among aspects such as economic, social, and environmental must be achieved. Urban greening, a tool for urban planning is one of the solutions being seen by different stakeholders globally in addressing urban problems. However, in the process of urban development, gentrification, an unchecked phenomenon arises. The movement of middle class people to either developed or redeveloped urban areas can possibly entail social issues such as displacement and exclusivity of urban …
Critical Success Factors For Digital Transformation Implementation In The Construction Industry: An Integrated Fuzzy Cognitive Map And Ranking Analysis Approach, Tan Thanh Trang
Chulalongkorn University Theses and Dissertations (Chula ETD)
The process of digital transformation (DX) involves the systematic integration of digital technologies, processes, and skills at all levels and functions within an organization, industry, or ecosystem. The emergence and rapid spread of the coronavirus are accelerating DX in all industies and the construction industry is not an exception. Construction companies are on the verge of significant transformation driven by advancements and the adoption of digital technologies. However, knowledge and information about how to implement DX efficiently in construction firms are fragmented and limited. This leads to the failure of DX journey of the majority of construction firms. This research …
Global Oil Price Transmission To Domestic Diesel Prices, Andthe Impact On Listed Firm's Profitability And Stock Market Returns : Evidence From Thailand, Koravik Renuros
Global Oil Price Transmission To Domestic Diesel Prices, Andthe Impact On Listed Firm's Profitability And Stock Market Returns : Evidence From Thailand, Koravik Renuros
Chulalongkorn University Theses and Dissertations (Chula ETD)
This research paper provides a comprehensive analysis of the dynamics of volatile oil prices over the past two decades, with a focus on the stock exchange of Thailand from the period of 2004 to 2022. Firstly, the study utilizes the Vector Autoregressive Model (VAR) technique to examine the impact of global oil price fluctuations on domestic fuel prices and the stock market in Thailand. The findings reveal that changes in global oil prices have a delayed and indirect effect on the Thai stock market. The transmission of volatility through domestic diesel prices is a crucial factor in this relationship. Notably, …
An Exploratory Study Of Online Socialising And Hiv-Related High-Risk Sexual Behavior Among University Students In Chengdu, People’ S Republic Of China, Qin Bo
Chulalongkorn University Theses and Dissertations (Chula ETD)
Young students in China have emerged as a high-risk demographic for HIV infection. Recent research findings confirm that engaging in unprotected sex with multiple partners remains the primary contributor to HIV transmission. However, in light of the ever-evolving landscape of network socialization and the deepening comprehension of HIV among young students, their attitudes and behaviors towards the virus have exhibited distinct characteristics. This study focuses on university and college students in Chengdu as the target population, aiming to comprehensively comprehend the present state and distinctive patterns of their sexual conduct, particularly high-risk sexual behavior. Moreover, it investigates the influence of …
Quantifying Multiple Uncertainties In Modelling Shallow Water-Sediment Flows: A Stochastic Galerkin Framework With Haar Wavelet Expansion And An Operator-Splitting Approach, Ji Li, Zhixian Cao, Alistair G.L. Borthwick
Quantifying Multiple Uncertainties In Modelling Shallow Water-Sediment Flows: A Stochastic Galerkin Framework With Haar Wavelet Expansion And An Operator-Splitting Approach, Ji Li, Zhixian Cao, Alistair G.L. Borthwick
School of Engineering, Computing and Mathematics
No abstract provided.
Analysis Of Adult Dental Emergencies At A Medical Center In Southern Taiwan, Chiung-Lin Huang, I-Jeng Yeh, Ying-Chun Lin, Chung-Fan Chiu, Je-Kang Du
Analysis Of Adult Dental Emergencies At A Medical Center In Southern Taiwan, Chiung-Lin Huang, I-Jeng Yeh, Ying-Chun Lin, Chung-Fan Chiu, Je-Kang Du
Journal of Dental Sciences
Abstract Background/purpose The need for dental emergency (DE) services has increased in recent years. This study therefore investigated the characteristics of patients presenting with DEs in a medical center in southern Taiwan. Materials and methods This was a retrospective study of 1964 adult patients who presented with a DE at the Kaohsiung Medical University Hospital in 2018. Medical records providing age, sex, time, day, past visit history, chief complaint, diagnosis, and treatment were collected and analyzed. Results The results revealed that men constituted 52.4% of the patients with DEs, the average age was 45.6 years, and the age distribution peak …
Methylation Related Genes Are Associated With Prognosis Of Patients With Head And Neck Squamous Cell Carcinoma Via Altering Tumor Immune Microenvironment, Yubin Cao, Xudong Tian, Congyu Shi, Shan Liu, Chengzhi Zhao, Xiaoyi Wang
Methylation Related Genes Are Associated With Prognosis Of Patients With Head And Neck Squamous Cell Carcinoma Via Altering Tumor Immune Microenvironment, Yubin Cao, Xudong Tian, Congyu Shi, Shan Liu, Chengzhi Zhao, Xiaoyi Wang
Journal of Dental Sciences
Abstract Background/purpose Analysis of methylomes may enable prognostic stratification in patients with head and neck squamous cell carcinoma (HNSCC). This study aimed to identify methylation-related differentially expressed genes (mrDEGs), and to assess their efficacy in predicting patients’ survival, tumor immune microenvironment alterations and immune checkpoints in patients with HNSCC. Materials and methods The methylome and transcriptome data of 528 HNSCC and 50 normal samples from TCGA database were used as training cohort. We identified mrDEGs and constituted a risk score model using Kaplan-Meier analysis and multivariate Cox regression. The prognostic efficacy of the risk score was validated in GSE65858 and …
Periodic Leave: An Analysis Of Menstrual Leave As A Legal Workplace Benefit, Hilary H. Price
Periodic Leave: An Analysis Of Menstrual Leave As A Legal Workplace Benefit, Hilary H. Price
Oklahoma Law Review
No abstract provided.
How El Salvador Has Changed U.S. Law By A Bit: The Consequences For The Ucc Of Bitcoin Becoming Legal Tender, Brian M. Mccall
How El Salvador Has Changed U.S. Law By A Bit: The Consequences For The Ucc Of Bitcoin Becoming Legal Tender, Brian M. Mccall
Oklahoma Law Review
No abstract provided.
Making A Life’S Work, Roberta F. Mann
Restraints Of The Body Or Of The Mind: Conflicting Interpretations Of The Physical Restraint Sentencing Enhancement, Heather Crabill
Restraints Of The Body Or Of The Mind: Conflicting Interpretations Of The Physical Restraint Sentencing Enhancement, Heather Crabill
Oklahoma Law Review
No abstract provided.
Money, Money, Money: Revenue Is Funny In A Mcgirt World, Amy Oltmanns
Money, Money, Money: Revenue Is Funny In A Mcgirt World, Amy Oltmanns
Oklahoma Law Review
No abstract provided.
Foreword: Ending Mass Incarceration, Guha Krishnamurthi
Foreword: Ending Mass Incarceration, Guha Krishnamurthi
Oklahoma Law Review
No abstract provided.
Nonfatal Death Sentences, Jacob Bronsther
The Inherent Problem With Mass Incarceration, Raff Donelson
The Inherent Problem With Mass Incarceration, Raff Donelson
Oklahoma Law Review
No abstract provided.
Getting To “Prisoner As Neighbor”, Avlana K. Eisenberg
Getting To “Prisoner As Neighbor”, Avlana K. Eisenberg
Oklahoma Law Review
No abstract provided.
Movement Constitutionalism, Brandon Hasbrouck
Movement Constitutionalism, Brandon Hasbrouck
Oklahoma Law Review
No abstract provided.
A Second Look For Children Sentenced To Die In Prison, Kathryn E. Miller
A Second Look For Children Sentenced To Die In Prison, Kathryn E. Miller
Oklahoma Law Review
No abstract provided.
Predicting Munsell Color For Turfgrass Leaves, William L. Berndt, Roch E. Gaussoin
Predicting Munsell Color For Turfgrass Leaves, William L. Berndt, Roch E. Gaussoin
Department of Agronomy and Horticulture: Faculty Publications
Linking turfgrass color to hue, value, chroma (H V/C) in the Munsell Plant Tissue Color Book is a visual comparison process for specifying and communicating plant color. If subjectivity of visual comparison can be mitigated, then accuracy of color matching may be improved. Research was conducted to develop an algorithm predicting H V/C from CIE-xyY color (xyY) in digital images of leaves of four turfgrasses. First, value-chroma (V/C) arrays for Munsell hue groups 5Y, 2.5GY, 5GY, 7.5GY, 10GY, and 2.5G were converted to xyY. Next, chromaticity (xy) plots from each array were fitted with …
Isolation And Characterization Of Bacteriophage Targeting Acute Hepatopancreatic Necrosis Disease-Causing Vibrio Parahaemolyticus, Khrongkhwan Thammatinna
Isolation And Characterization Of Bacteriophage Targeting Acute Hepatopancreatic Necrosis Disease-Causing Vibrio Parahaemolyticus, Khrongkhwan Thammatinna
Chulalongkorn University Theses and Dissertations (Chula ETD)
Vibrio parahaemolyticus causing Acute hepatopancreatic necrosis disease (VPAHPND) has been a major cause of serious shrimp aquaculture economic losses. Moreover, many isolates have exhibited the resistance of various antibiotic drugs. Most recently, bacteriophage or phage, the killer of bacteria, has been gaining interest as an alternative tool to prevent and control pathogens. In this study, we discovered two novel vibriophages - vibriophage Seahorse and vibriophage phiKT1024 – that target various strains of VPAHPND. vibriophage Seahorse and vibriophage phiKT1024 were assigned to the family Siphoviridae and Myoviridae, respectively. Based on the cut-off of genome size that is less than 200 kbp …
Development Of Paper-Based Electrochemical Immunosensor For Sars-Cov-2 Detection, Jutamas Jaewjaroenwatana
Development Of Paper-Based Electrochemical Immunosensor For Sars-Cov-2 Detection, Jutamas Jaewjaroenwatana
Chulalongkorn University Theses and Dissertations (Chula ETD)
This dissertation aimed to develop a simple and low-cost electrochemical sensing platform for detecting SAR-CoV-2 antigen. The proposed sensor combined the innovative disposable paper-based immunosensor and cost-effective plant-based anti-SARS-CoV-2 monoclonal antibody, extracted from Nicotiana benthamiana. The cellulose nanocrystal was modified on screen-printed graphene electrode to provide the COOH functional groups on electrode surface, leading to the high ability for antibody immobilization. The quantification of the presence receptor binding domain (RBD) spike protein of SARS-CoV-2 was performed using differential pulse voltammetry by monitoring the changing current of [Fe(CN)6]3-/4- redox solution. The current change of [Fe(CN)6]3-/4- before and after the presence of …
Arenes Production Via Hydrodeoxygenation Of Oxygenated Compounds Derived From Pyrolysis Of Biomass And Polyethylene Terephthalate Using Co/Tio2 Catalyst, Surachet Hongkailers
Arenes Production Via Hydrodeoxygenation Of Oxygenated Compounds Derived From Pyrolysis Of Biomass And Polyethylene Terephthalate Using Co/Tio2 Catalyst, Surachet Hongkailers
Chulalongkorn University Theses and Dissertations (Chula ETD)
Arising from the need for sustainable developments announced by the United Nations, converting biomass and waste plastic into fuels and chemicals has become an interesting topic, contributing to the reduction of solid waste and the generation of high-value products, closing the loop of the circular economy towards a sustainable and waste-free society. Herein, the production of green chemicals from hydrodeoxygenation (HDO) of oxygenated compounds derived from lignocellulosic biomass and waste plastics using Co-based catalysts has been investigated. Initially, two types of TiO2 (anatase [TiO2-A] and rutile [TiO2-R]) were compared in 4-propylguaiacol conversion. Both types of Co/TiO2 catalysts facilitated the HDO …
Glycosylation Of N-Pentenyl Glycoside Activated By Bromodiethylsulfonium Salt, Supanat Buntasana
Glycosylation Of N-Pentenyl Glycoside Activated By Bromodiethylsulfonium Salt, Supanat Buntasana
Chulalongkorn University Theses and Dissertations (Chula ETD)
n-Pentenyl glycosides (NPGs) are a significant class of glycosyl donors with dual functionality, serving as both protecting groups for the anomeric hydroxyl and leaving groups upon activation with halonium activators such as N-bromosuccinimide (NBS) or N-iodosuccinimide (NIS). However, the activation of less reactive glycosyl donors with these reagents has proven to be sluggish and inefficient. Recently, bromodiethylsulfonium bromopentachloroantimonate (BDSB) has emerged as a highly efficient brominating reagent that can be readily prepared and purified through crystallization. In this study, we explored the potential of BDSB as a halonium activator for NPGs in chemical glycosylation reactions. By using BDSB as the …
Bioactive Compounds From Leaves And Heartwoods Of Santol Sandoricum Koetjape Merr., Tai Xuan Hoa Hang
Bioactive Compounds From Leaves And Heartwoods Of Santol Sandoricum Koetjape Merr., Tai Xuan Hoa Hang
Chulalongkorn University Theses and Dissertations (Chula ETD)
Phytochemical and biological investigations were conducted on the leaves and heartwoods of Sandoricum koetjape. From the potent methanol extracts, twenty known compounds (3-15, 17-20, 28-30), three new compounds (1-2, 21), and seven novel compounds (16, 22-27) were isolated. Their structures were elucidated by spectroscopic data analysis (1D, 2D NMR and HRESIMS). Isolated compounds were evaluated for enzyme inhibitory activity against α-glucosidase and cytotoxicity activity. Quercetin (10) from the leaves and (+)-lyoniresinol 3-α-O-b-D-glucopyranoside (30) from the heartwoods showed significant inhibitory activity against yeast α-glucosidase with IC50 value of 2.2±0.1 and 2.8±0.8 mM, respectively which were around 40 times lower than that …
Lignin Micro-Nano Particles From Organosolv Lignin Of Domestically Available Oil Palm Empty Fruit Bunch, Orawan Thasanabenjakul
Lignin Micro-Nano Particles From Organosolv Lignin Of Domestically Available Oil Palm Empty Fruit Bunch, Orawan Thasanabenjakul
Chulalongkorn University Theses and Dissertations (Chula ETD)
Lignin nanoparticles have potential value in biomedical and environmental applications. Utilizing oil palm empty fruit bunches (OPEFB) for lignin nanoparticles production can improve the economics of oil palm. In this study, lignin was extracted from OPEFB by acid-catalyzed organosolv method, using either glycerol/glycerol carbonate or ethanol/water as the solvent. The FT-IR spectra of the lignin particles extracted by glycerol/glycerol carbonate and ethanol/water suggest that the ethanol/water system was able to remove more functional groups from the OPEFB than glycerol/glycerol carbonate. Without the homogenization, the organosolv lignin particle sizes extracted by glycerol/glycerol carbonate and ethanol/water were broadly distributed, ranging between 8-154 …
Detection Of Egfr Mutations In Lung Cancer Based On Oxford Nanopore Sequencing Technology, Patinya Akkhasutthikun
Detection Of Egfr Mutations In Lung Cancer Based On Oxford Nanopore Sequencing Technology, Patinya Akkhasutthikun
Chulalongkorn University Theses and Dissertations (Chula ETD)
Epidermal growth factor receptor (EGFR) mutation is an important and highly prevalent oncogene driver in patients with non-small cell lung cancer (NSCLC) in East Asia. The detection of EGFR mutations is a standard biomarker testing that routinely performed in patients with advanced lung cancer for the selection of targeted therapy. Here, we aimed to develop a portable and cost-effective new technique for detecting EGFR 19Del, T790M and L858R mutations based on blocker displacement amplification (BDA) combined with Oxford Nanopore Technologies (ONT). The method optimization was performed using wild-type and mutant EGFR allele generated from lung cancer cell lines. The assay …
Roles Of Mtor Complex 2 In Canonical Wnt Signaling In Glioblastoma., Tankun Banlue
Roles Of Mtor Complex 2 In Canonical Wnt Signaling In Glioblastoma., Tankun Banlue
Chulalongkorn University Theses and Dissertations (Chula ETD)
Glioblastoma (GBM) is the most common type of primary brain tumor in adults, comprising 75% of cases. The failure of GBM treatments is closely related to a subset of cells known as glioblastoma stem cells (GSCs), which possess stemness characteristics. While the Wnt signaling pathway plays a crucial role in regulating stem cell homeostasis, the interplay between this pathway and the mTORC2 signaling pathway in GBM remains unclear. Thus, this research aimed to investigate the collaborative regulation of stemness-related mechanisms by mTORC2 and canonical Wnt signaling pathways in glioblastoma using 3D spheroid culture. The study found that inhibiting mTORC2 resulted …