Digital Commons Network^™

Myocardial Contractility Pattern Characterization In Radiation-Induced Cardiotoxicity Using Magnetic Resonance Imaging: A Pilot Study With Contractix, El-Sayed H Ibrahim, Antonio Sosa, Sherry-Ann Brown, Dayeong An, Slade Klawikowski, John Baker, Carmen Bergom

2020-Current year OA Pubs

Radiation therapy (RT) plays an integral role in treating thoracic cancers, despite the risk of radiation-induced cardiotoxicity. We hypothesize that our newly developed magnetic resonance imaging (MRI)-based contractility index (ContractiX) is a sensitive marker for early detection of RT-induced cardiotoxicity in a preclinical rat model of thoracic cancer RT. Adult salt-sensitive rats received image-guided heart RT and were imaged with MRI at 8 weeks and 10 weeks post-RT or sham. The MRI exam included cine and tagging sequences to measure left-ventricular ejection fraction (LVEF), mass, myocardial strain, and ContractiX. Furthermore, ventricular torsion, diastolic strain rate, and mechanical dyssynchrony were measured. …

Evaluation And Revision Of The Practice Environment Scale Of The Nursing Work Index For Acute Care Hospital Staff Nurses, Caitlin M. Campbell

Dissertations

The Practice Environment Scale of the Nursing Work Index (PES-NWI) is the most frequently used instrument for measuring the nursing work environment. The original PES-NWI obtained its items directly from the parent instrument, the Nursing Work Index, which was developed in the 1980s. However, potential value change among younger generations and vast historical, social, and technological transformations in the way healthcare is provided may have led to different factors that compose a favorable work environment for nurses working today.

The Weekly Challenger, December 22, 2022, The Weekly Challenger, Et Al

Weekly Challenger Newspaper Collection

The December 22, 2022, issue of The Weekly Challenger.

Movements In C Minor: Vocal Soundscapes In Eastern Amazonia (Araweté), Guilherme Orlandini Heurich

Tipití: Journal of the Society for the Anthropology of Lowland South America

This article examines the capture of forest spirits through music in the Anĩ pihi speech-songs of the Araweté, a small Amerindian society in Eastern Amazonia, Brazil. The Anĩ pihi are unique in their combination of spoken and sung forms, in which spirits and divinities are voiced by a ritual specialist. I explore how particular sounds index the presence of different kinds of others (gods and spirits), and how these sounds are, in turn, related to the use of reported speech – in other words, how others talk about other others in sung form. As such, the Anĩ pihi are a …

Table Of Contents

BYU Law Review

No abstract provided.

The Original “Market” Understanding Of The Commerce Clause: Insights From Early Federal Government Practice And Precedent, Robert J. Pushaw Jr.

BYU Law Review

No abstract provided.

Nontraditional Investors, Jennifer S. Fan

BYU Law Review

In recent years, nontraditional investors have become a major player in the startup ecosystem. Under the regulatory regime of U.S. securities law, those in the public realm are heavily regulated, while those in the private realm are largely left alone. This public-private divide, which is a fundamental organizing principle of securities law, has eroded with the rise of nontraditional investors. While legal scholars have addressed the impact of some of these nontraditional investors individually, their collective impact on deal terms, deal timelines, due diligence, and board configuration has not been discussed in a holistic manner; neither has their impact on …

The Congruent Constitution (Part Two): Reverse Incorporation, Jay S. Bybee

BYU Law Review

In Bolling v. Sharpe (1954), a companion case to Brown v. Board of Education, the Supreme Court thought it “unthinkable” that the Equal Protection Clause would not apply to the federal government as well as the states and declared it “reverse incorporated” through the Due Process Clause of the Fifth Amendment. The Equal Protection Clause is the most familiar example of reverse incorporation, but it is neither the first nor the only provision of the Constitution that, by its terms, applies to the states alone, but which the Supreme Court has made applicable to the federal government through the Due …

The Fiscal Sustainability Of Retiree Health Care Benefits Among New York State School Districts, Robert Bifulco, Minch Lewis, Iuliia Shybalkina

Center for Policy Research

We examine spending on retiree health care as a percentage of revenues for a sample of New York State school districts. The fiscal burden of these benefits grew from 2010 to 2021, and big city school districts have faced the largest burdens. Assuming CBO forecasts regarding growth in health care costs and continuation of recent trends in revenue growth, we project that the burden of retiree health care benefits will exceed 10 percent of revenue by 2050. Projected burdens are greatest big city and high need rural districts. We discuss cutting benefits and pre-funding as possible policy responses.

Analysis Of Discriminatory Measures From European Union Renewable Energy Directive Ii To Indonesia As A Palm Oil Producer Country, Enrico Denis Sihotang

Indonesia Law Review

On 21 December 2018, the European Union (EU) issued a regulation titled Renewable Energy Directive II (RED II), where the RED II policy introduced the indirect land use change (ILUC) criteria for palm oil. RED II states that palm oil is classified as a commodity with a “ high ILUC risk” type, and as such, the EU will gradually reduce palm oil consumption and no longer use palm oil by 2030. Indonesia brought this issue to WTO in 2020. Indonesia, through its consultation, argued that the RED II is inconsistent with the few provisions of the General Agreement on Tariffs …

Identifying The Gaps Between Public Health Training And Practice: A Workforce Competencies Comparative Analysis, Osnat Bashkin, Robert Otok, Ori Kapra, Kasia Czabanowska, Paul Barach, Orna Baron-Epel, Keren Dopelt, Mariusz Duplaga, Lore Leighton, Hagai Levine, Fiona Macleod, Yehuda Neumark, Stephanie Paillard-Borg, Theodore Tulchinsky, Zohar Mor

College of Population Health Faculty Papers

Objectives: The study aimed to generate insights on how best to enhance the compatibility between Public Health training program competencies and the implementation of competencies required by employers to address current and emerging public health needs.

Methods: A survey adapted from the WHO-ASPHER Competency Framework for the Public Health Workforce was conducted online among Israeli public health managers from August to November 2021. The survey was formulated to mirror Essential Public Health Operations. Forty-nine managers participated (37.6% response rate) in an assessment of 44 public health competencies and the core organizational public health operations.

Results: Analysis of Essential Public Health …

Appendices To Inglis, Octonaries: Titles And Dedications From Other Mss, Mss Containing The ‘G.D.’ And ‘Velde’ Sonnets, Who Was ‘G.D.’?, Jamie Reid Baxter

Studies in Scottish Literature

Three Appendices to the preceding article on Esther Inglis's Octonaries: (1) transcribe the Titles and Dedications in other manuscripts; (2) record the five MSS containing the ‘G.D.’ and ‘Velde’ Sonnets discussed in the article; and (3) review possibilities for the identity of 'G.D.', proposing that it was George Douglas, a gifted vernacular poet and translator of Boethius.NOTE: the current file (August 9 2023) includes further minor corrections. Please refresh your browser if you downloaded a previous version. SSL Ed.

Robert Watson’S Lectures At St. Andrews: Logic, Rhetoric And Metaphysics, Rosaleen Greene-Smith Keefe

Studies in Scottish Literature

Examines the contributions to rhetoric of Robert Watson (1730?-1781), Professor of Logic, Rhetoric, and Metaphysics at the University of St. Andrews from
1756-1778, and Principal from 1778-1781, based on surviving manuscript sources at St Andrews, and demonstrates the philosophic diversity in rhetorical theory at this time, showing differences among the Scottish literati on the epistemology of language and the origin of grammar, identifying some contrasts and connections between Watson and his near contemporaries Adam Smith, Hugh Blair, and George Campbell, and suggesting his distinctive place in the development of 18th century rhetoric and the history of English studies.

Scott’S Reparative Land Ethic, Nigel Leask

Studies in Scottish Literature

A review essay discussing Susan Oliver's "important and convincing" book Walter Scott and the Greening of Scotland: Emergent Ecologies of a Nation (Cambridge University Press, 2021), noting Scott's land ethic and active role in managing his estate at Abbotsford and in afforestation, and suggesting that Oliver's book presents "a cumulative literary history of Scotland’s ecologies," so that Scott's poetry and novels "assume a new relevance for 21st century readers".

Books Received And Noted, Patrick Scott

Studies in Scottish Literature

Brief reviews or notices of some recent books about Scottish literature, Scottish writers, and related topics.

Cocaine Sensitizes The Cd4+ T Cells For Hiv Infection By Co-Stimulating Nfat And Ap-1, Adhikarimayum Lakhikumar Sharma, Dylan Shafer, Daniel Netting, Mudit Tyagi

Center for Translational Medicine Faculty Papers

The productive infection of HIV, which generates new viral progeny, depends on the activation status of the cell. In this study, we found cocaine exposure sensitizes partially active CD4+ T cells and makes them poised for productive HIV infection. We discovered that cocaine treatment enhances the metabolic state of the cells by co-stimulating several transcription factors, mainly NFAT and AP-1, the two transcription factors, which specifically play a crucial role in enhancing both HIV and the overall cellular gene expression in T cells. We found that cocaine-induced AP-1 works in tandem with NFAT to boost HIV transcription. The enhanced HIV …

Nonconsensual Family Obligations, Emily J. Stolzenberg

BYU Law Review

Even as the pandemic has both highlighted and compounded the challenges many U.S. families face in meeting their members’ basic needs, efforts to expand public subsidies for caretaking have gained little traction. Scholars have identified many historical and practical reasons for Americans’ entrenched skepticism toward the welfare state. Ideas matter, too, and this Article uncovers and critiques one that works to limit collective financial responsibility for families: the conviction that family support obligations must be legitimated through consent.

In family law, as in liberal political theory, consent works to reconcile state regulation with individual freedom. But because consent is a …

Correlation Of Angiogenic Biomarkers To Tumor Progression And Angiogenesis In Cervical Cancer Cell (Caski)-Implanted Nude Mice, Nakorn Mathuradavong, Umarat Srisawat, Bhornprom Yoysungnoen, Nattapon Sookprasert

Asian Medical Journal and Alternative Medicine

Introduction: Several studies have indicated that microvascular density (MVD) and the expressions of angiogenic biomarkers were associated with tumor growth and angiogenesis in cervical cancer. However, the results were incomplete and inconsistent.

Objectives: To determine the correlation of the angiogenic biomarkers, including vascular endothelial growth factor (VEGF), hypoxia-inducible factor 1-alpha (HIF-1α), cyclooxygenase-2 (COX-2), and epidermal growth factor receptor (EGFR), to tumor progression and angiogenesis in cervical cancer cell (CaSki)-implanted nude mice model.

Methods: 10×10⁶ of CaSki cells were injected into the female nude mice (n = 50) to establish subcutaneous tumors. The tumor size was measured every 3 days …

“Model Minorities” In The Classroom? Positive Evaluation Bias Towards Asian Students And Its Consequences, Ying Shi, Maria Zhu

Center for Policy Research

The fast-growing demographic group of Asian Americans is often perceived as a “model minority.” This paper establishes empirical evidence of this stereotype in the context of education and then analyzes its consequences. We show that teachers rate Asian students’ academic skills more favorably than observationally similar White students in the same class, even after accounting for test performance and behavior. This contrasts with teachers’ lower likelihood of favoring Black and Hispanic students. Notably, teachers respond to the presence of any Asian student in the classroom by exacerbating Black-White and Hispanic-White assessment gaps. This suggests that the “model minority” stereotype can …

Clinical Cancer And Direct-To-Consumer Genetic Test Result-Sharing Behavior: Findings From Hints 2020, Sukh Makhnoon, Robert Yu, Susan K Peterson, Sanjay Shete

Faculty, Staff and Student Publications

INTRODUCTION: Sharing genetic test results with different stakeholders such as family members, healthcare providers and genetic counselors (HCP/GCs), spouses/partners, and friends is a health behavior of clinical importance in genomic medicine.

METHODS: Using nationally representative population-based data collected from the Health Information National Trends Survey (HINTS 5, cycle 4), we identified the prevalence and factors associated with genetic test result-sharing behavior for high-risk cancer tests, genetic health risk tests, and ancestry tests within four groups: HCP/GCs, first-degree relatives (FDRs), spouse/partner, and friend/other.

RESULTS: Overall, 68.4% of those who underwent high-risk cancer genetic testing shared their results with FDRs, whereas 89.9% …

A Review On Nanomaterials And Nanohybrids Based Bio-Nanocomposites For Food Packaging, Kalpani Y. Perera, Amit K. Jaiswal, Swarna Jaiswal

Articles

With an increasing demand for a novel, eco-friendly, high-performance packaging material “bio-nanocomposites” has attracted great attention in recent years. The review article aims at to evaluating recent innovation in bio-nanocomposites for food packaging applications. The current trends and research over the last three years of the various bio-nanocomposites including inorganic, organic nanomaterials, and nanohybrids, which are suitable as food packaging materials due to their advanced properties such as high mechanical, thermal, barrier, antimicrobial, and antioxidant are described in detail. In addition, the legislation, migration studies, and SWOT analysis on bio-nanocomposite film have been discussed. It has been observed that the …

Late-Stage Functionalization Through Click Chemistry Provides Glut5-Targeting Glycoconjugate As A Potential Pet Imaging Probe, Adelina Oronova, Marina Tanasova

Michigan Tech Publications, Part 1

The targeting of facilitative sugar transporters (GLUTs) has been utilized in the development of tools for diagnostics and therapy. The interest in this area is promoted by the phenomenon of alterations in cellular metabolic processes that are linked to multitudes of metabolic disorders and diseases. However, nonspecific targeting (e.g., glucose-transporting GLUTs) leads to a lack of disease detection efficiency. Among GLUTs, GLUT5 stands out as a prominent target for developing specific molecular tools due to its association with metabolic diseases, including cancer. This work reports a non-radiolabeled fluoride (19F) coumarin-based glycoconjugate of 2,5-anhydro-D-mannitol as a potential PET imaging probe that …

Rare Diseases And Space Health: Optimizing Synergies From Scientific Questions To Care, Maria Puscas, Gabrielle Martineau, Gurjot Bhella, Penelope E Bonnen, Phil Carr, Robyn Lim, John Mitchell, Matthew Osmond, Emmanuel Urquieta, Jaime Flamenbaum, Giuseppe Iaria, Yann Joly, Étienne Richer, Joan Saary, David Saint-Jacques, Nicole Buckley, Etienne Low-Decarie

Faculty, Staff and Students Publications

Knowledge transfer among research disciplines can lead to substantial research progress. At first glance, astronaut health and rare diseases may be seen as having little common ground for such an exchange. However, deleterious health conditions linked to human space exploration may well be considered as a narrow sub-category of rare diseases. Here, we compare and contrast research and healthcare in the contexts of rare diseases and space health and identify common barriers and avenues of improvement. The prevalent genetic basis of most rare disorders contrasts sharply with the occupational considerations required to sustain human health in space. Nevertheless small sample …

New Prospect Ny Llc V. Garcia

All Decisions

No abstract provided.

Hiv-Seropositive Patients’ Experiences With Social Workers: A South African Hiv+ Social Worker’S Reflective Log, Delarise Maud Mulqueeny

The Qualitative Report

Social workers play a pivotal role in HIV-seropositive patients’ treatment and care within South African public antiretroviral treatment (ART) programs. This article is a reflective log of an HIV-seropositive social worker’s observations and reflections on her positionality during a study on HIV-seropositive patients’ experiences of the public ART program in eThekwini, KwaZulu-Natal, South Africa. The primary investigator (PI) utilized various tools and techniques including reflexive bracketing, participatory action research and a reflexive diary to navigate a sensitive study. This was while being cognizant of the fluidity of her insider/outsider positionality. The disclosure of the PI’s HIV-seropositive status culminated in all …

The Discrimination Of Self From Other As A Component Of Empathy., Charlotte Little, Elizaveta Solomonova, Maiya Jordan, Natalie Klein, Ben Jennings, Gunnar Schmidtmann, Héctor Leos, Ian Gold

School of Health Professions

Despite the centrality of empathy in human social life, there is no widely agreed definition or characterization of the concept of empathy. A common thread in many of the proposed definitions, however, is that empathy presupposes the discrimination of self and other on the grounds that, to empathize with another individual, the mental state of the target individual must first be distinguished from the empathizer's own mental state. The purpose of this study is to investigate this proposal empirically. We employed a paradigm in which participants rated the emotional valence and degree of arousal of 93 facial expressions of mental …

Therapies For Mitochondrial Disorders, Kayli Sousa Smyth, Anne Mulvihill

SURE Journal: Science Undergraduate Research Experience Journal

Mitochondria are cytoplasmic, double-membrane organelles that synthesise adenosine triphosphate (ATP). Mitochondria contain their own genome, mitochondrial DNA (mtDNA), which is maternally inherited from the oocyte. Mitochondrial proteins are encoded by either nuclear DNA (nDNA) or mtDNA, and both code for proteins forming the mitochondrial oxidative phosphorylation (OXPHOS) complexes of the respiratory chain. These complexes form a chain that allows the passage of electrons down the electron transport chain (ETC) through a proton motive force, creating ATP from adenosine diphosphate (ADP). This study aims to explore current and prospective therapies for mitochondrial disorders (MTDS). MTDS are clinical syndromes coupled with abnormalities …

Anthelmintic Resistance In Sheep Across Ireland And The Uk: A Literature Review Of The In Vivo Versus In Vitro Methods, Megan Tumulty

SURE Journal: Science Undergraduate Research Experience Journal

Background: The animal welfare and production consequences of gastrointestinal nematode infections, namely Nematodirus battus, on sheep are compelling. The control of gastrointestinal infections has been heavily reliant on the administration of anthelmintics since their introduction into mainstream use in 1960. However, their frequent and often excessive use has resulted in anthelmintic resistance being reported extensively in several gastrointestinal nematode species. The prevalence of anthelmintic resistance as well as the increase in the number of cases of multiple-drug resistance in nematode populations now poses substantial hindrance on the viability of sheep production systems. However, despite the threat N. battus poses …

The Pragmatism Of Anyone, Paul Headrick

Spring: The Journal of the E. E. Cummings Society

No abstract provided.

Cummings The Performer, Millie Kidd

Spring: The Journal of the E. E. Cummings Society

No abstract provided.