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2022

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Isms In The Twenty-First Century: The Evolution Of Systemic Discrimination, Taylor Neas Jul 2022

Isms In The Twenty-First Century: The Evolution Of Systemic Discrimination, Taylor Neas

University Honors College

Long have the concepts of racism, sexism, and classism existed in human history. However, their definitions and practice have evolved over time. Modernly, they are all considered forms of discrimination. Recently, these topics have been a source of discussion among many disciplines. This thesis serves to add to existing literature outlining the history of these forms of discrimination and how they presented themselves in early American society. All three forms manifested in different forms in early civilizations before being adopted in colonial America. This work also serves to outline how these forms of discrimination exist in present day America. While …


Ccl4 Functions As A Biomarker Of Type 2 Airway Inflammation, Yoshiki Kobayashi, Hanh Hong Chu, Akira Kanda, Yasutaka Yun, Masami Shimono, Linh Manh Nguyen, Akitoshi Mitani, Kensuke Suzuki, Mikiya Asako, Hiroshi Iwai Jul 2022

Ccl4 Functions As A Biomarker Of Type 2 Airway Inflammation, Yoshiki Kobayashi, Hanh Hong Chu, Akira Kanda, Yasutaka Yun, Masami Shimono, Linh Manh Nguyen, Akitoshi Mitani, Kensuke Suzuki, Mikiya Asako, Hiroshi Iwai

Faculty, Staff and Student Publications

Eosinophilic airway inflammatory disease is associated with bronchial asthma, with eosinophilic chronic rhinosinusitis (ECRS) typical of refractory type 2 airway inflammation. CCL4 produced at local inflammatory sites is involved in them via the accumulation and activation of type 2 inflammatory cells, including eosinophils. The detailed mechanism of CCL4 production remains unclear, and also the possibility it could function as a biomarker of type 2 airway inflammation remains unresolved. In this study, we evaluated CCL4 mRNA expression and production via the TSLP receptor (TSLPR) and toll-like receptors (TLRs) or proteinase-activated receptor-2 (PAR2) in BEAS-2B bronchial epithelial cells co-incubated with purified eosinophils …


Nmr And Metabolomics—A Roadmap For The Future, David S. Wishart, Leo L. Cheng, Valérie Copié, Arthur S. Edison, Hamid R. Eghbalnia, Jeffrey C. Hoch, Goncalo J. Gouveia, Wimal Pathmasiri, Robert Powers, Tracey B. Schock, Lloyd W. Sumner, Mario Uchimiya Jul 2022

Nmr And Metabolomics—A Roadmap For The Future, David S. Wishart, Leo L. Cheng, Valérie Copié, Arthur S. Edison, Hamid R. Eghbalnia, Jeffrey C. Hoch, Goncalo J. Gouveia, Wimal Pathmasiri, Robert Powers, Tracey B. Schock, Lloyd W. Sumner, Mario Uchimiya

Department of Chemistry: Faculty Publications

Metabolomics investigates global metabolic alterations associated with chemical, biological, physiological, or pathological processes. These metabolic changes are measured with various analytical platforms including liquid chromatography-mass spectrometry (LC-MS), gas chromatographymass spectrometry (GC-MS) and nuclear magnetic resonance spectroscopy (NMR). While LC-MS methods are becoming increasingly popular in the field of metabolomics (accounting for more than 70% of published metabolomics studies to date), there are considerable benefits and advantages to NMR-based methods for metabolomic studies. In fact, according to PubMed, more than 926 papers on NMR-based metabolomics were published in 2021—the most ever published in a given year. This suggests that NMR-based metabolomics …


Martinez V. Avila, Jr., 138 Nev. Adv. Op. 49 (June 30, 2022), Candace Mays Jul 2022

Martinez V. Avila, Jr., 138 Nev. Adv. Op. 49 (June 30, 2022), Candace Mays

Nevada Supreme Court Summaries

The Supreme Court of Nevada reviewed a district court’s decision granting legal paternity to the biological father of a child over the objection of the person who assumed paternity over the child pursuant to a Voluntary Parenting Agreement. The Court held that while paternity can be established and memorialized through written instruments, biological paternity is supreme.


Molecular Profiles Of Serum-Derived Extracellular Vesicles In High-Grade Serous Ovarian Cancer, Li Zhao, Sara Corvigno, Shaolin Ma, Joseph Celestino, Nicole D Fleming, Richard A Hajek, Adrian Lankenau Ahumada, Nicholas B Jennings, Erika J Thompson, Hongli Tang, Shannon N Westin, Amir A Jazaeri, Jianhua Zhang, P Andrew Futreal, Anil K Sood, Sanghoon Lee Jul 2022

Molecular Profiles Of Serum-Derived Extracellular Vesicles In High-Grade Serous Ovarian Cancer, Li Zhao, Sara Corvigno, Shaolin Ma, Joseph Celestino, Nicole D Fleming, Richard A Hajek, Adrian Lankenau Ahumada, Nicholas B Jennings, Erika J Thompson, Hongli Tang, Shannon N Westin, Amir A Jazaeri, Jianhua Zhang, P Andrew Futreal, Anil K Sood, Sanghoon Lee

Faculty, Staff and Student Publications

Patients with high-grade serous ovarian cancer (HGSC) who have no visible residual disease (R0) after primary surgery have the best clinical outcomes, followed by patients who undergo neoadjuvant chemotherapy (NACT) and have a response enabling interval cytoreductive surgery. Clinically useful biomarkers for predicting these outcomes are still lacking. Extracellular vesicles (EVs) have been recognized as liquid biopsy-based biomarkers for early cancer detection and disease surveillance in other disease settings. In this study, we performed extensive molecular characterization of serum-derived EVs and correlated the findings with therapeutic outcomes in patients with HGSC. Using EV-DNA whole-genome sequencing and EV-RNA sequencing, we identified …


Two-Pore Channel Blockade By Phosphoinositide Kinase Inhibitors Ym201636 And Pi-103 Determined By A Histidine Residue Near Pore-Entrance, Canwei Du, Xin Guan, Jiusheng Yan Jul 2022

Two-Pore Channel Blockade By Phosphoinositide Kinase Inhibitors Ym201636 And Pi-103 Determined By A Histidine Residue Near Pore-Entrance, Canwei Du, Xin Guan, Jiusheng Yan

Faculty, Staff and Student Publications

Human two-pore channels (TPCs) are endolysosomal cation channels and play an important role in NAADP-evoked Ca2+ release and endomembrane dynamics. We found that YM201636, a PIKfyve inhibitor, potently inhibits PI(3,5)P2-activated human TPC2 with an IC50 of 0.16 μM. YM201636 also effectively inhibits NAADP-activated TPC2 and a constitutively-open TPC2 L690A/L694A mutant channel; whereas it exerts little effect when applied in the channel's closed state. PI-103, a YM201636 analog and an inhibitor of PI3K and mTOR, also inhibits human TPC2 with an IC50 of 0.64 μM. With mutational, virtual docking, and molecular dynamic simulation analyses, we found that YM201636 and PI-103 directly …


Title 8 U.S.C. § 1409 Of The United States Immigration And Nationality Act—Children Born Out Of Wedlock: Undermining Father's Rights And Perpetuating Gendered Parenthood In Citizenship Law, Melissa Fernandez Jul 2022

Title 8 U.S.C. § 1409 Of The United States Immigration And Nationality Act—Children Born Out Of Wedlock: Undermining Father's Rights And Perpetuating Gendered Parenthood In Citizenship Law, Melissa Fernandez

Florida Law Review

No abstract provided.


The Therapeutic Placebo: The Case For Patient Deception, Kathleen M. Boozang Jul 2022

The Therapeutic Placebo: The Case For Patient Deception, Kathleen M. Boozang

Florida Law Review

No abstract provided.


Halfway Out Of The Closet: Oncale'S Limitations In Protecting Homosexual Victims Of Sex Discrimination, Nailah A. Jaffree Jul 2022

Halfway Out Of The Closet: Oncale'S Limitations In Protecting Homosexual Victims Of Sex Discrimination, Nailah A. Jaffree

Florida Law Review

No abstract provided.


The Fiction Of Juvenile Right To Counsel: Waiver In The Juvenile Courts, Mary Berkheiser Jul 2022

The Fiction Of Juvenile Right To Counsel: Waiver In The Juvenile Courts, Mary Berkheiser

Florida Law Review

No abstract provided.


Privacy, Computers And The Patriot Act: The Fourth Amendment Isn’T Dead, But No One Will Insure It, Steven A. Osher Jul 2022

Privacy, Computers And The Patriot Act: The Fourth Amendment Isn’T Dead, But No One Will Insure It, Steven A. Osher

Florida Law Review

No abstract provided.


Section 404(A) Of The Clean Water Act: The Army Corps Of Engineers' Jurisdiction Over "All Other Waters", Philip Lammens Jul 2022

Section 404(A) Of The Clean Water Act: The Army Corps Of Engineers' Jurisdiction Over "All Other Waters", Philip Lammens

Florida Law Review

No abstract provided.


A Step Beyond: Adding Behavior Analysis To The Discussion Of Evolution, Natural Selection, And The Law, Katherine J. Kaminsky, Matthew W. Kirkhart Jul 2022

A Step Beyond: Adding Behavior Analysis To The Discussion Of Evolution, Natural Selection, And The Law, Katherine J. Kaminsky, Matthew W. Kirkhart

Florida Law Review

No abstract provided.


Brain Plasticity And Spanish Moss In Biolegal Analysis, Erin Ann O'Hara Jul 2022

Brain Plasticity And Spanish Moss In Biolegal Analysis, Erin Ann O'Hara

Florida Law Review

No abstract provided.


Evolution, Human Behavior, And Law: A Response To Owen Jones's Dunwody Lecture, Thomas S. Ulen Jul 2022

Evolution, Human Behavior, And Law: A Response To Owen Jones's Dunwody Lecture, Thomas S. Ulen

Florida Law Review

No abstract provided.


Evolutionary Biology Meets Determinism: Learning From Philosophy, Freud, And Spinoza, Steven Goldberg Jul 2022

Evolutionary Biology Meets Determinism: Learning From Philosophy, Freud, And Spinoza, Steven Goldberg

Florida Law Review

No abstract provided.


Pushing Evolutionary Analysis Of Law Or Evolving Law: Design Without A Designer, Jeffrey Evans Stake Jul 2022

Pushing Evolutionary Analysis Of Law Or Evolving Law: Design Without A Designer, Jeffrey Evans Stake

Florida Law Review

No abstract provided.


Proprioception, Non-Law, And Biolegal History, Owen D. Jones Jul 2022

Proprioception, Non-Law, And Biolegal History, Owen D. Jones

Florida Law Review

No abstract provided.


Pills, Patents, And Power: State Creation Of Gray Markets As A Limit On Patent Rights, Shubha Ghosh Jul 2022

Pills, Patents, And Power: State Creation Of Gray Markets As A Limit On Patent Rights, Shubha Ghosh

Florida Law Review

No abstract provided.


Transnational Codes Of Conduct Through Dialogue: Leveling The Playing Field For Developing-Country Workers, Claire Moore Dickerson Jul 2022

Transnational Codes Of Conduct Through Dialogue: Leveling The Playing Field For Developing-Country Workers, Claire Moore Dickerson

Florida Law Review

No abstract provided.


Grandparent Visitation Statutes: Do Legislatures Know The Way To Carry The Sleigh Through The Wide And Drifting Law?, Maegen E. Peek Jul 2022

Grandparent Visitation Statutes: Do Legislatures Know The Way To Carry The Sleigh Through The Wide And Drifting Law?, Maegen E. Peek

Florida Law Review

No abstract provided.


Amadou Diallo And The "Foreigner" Meme: Interpreting The Application Of Federal Court Interpreter Laws, Leslie V. Dery Jul 2022

Amadou Diallo And The "Foreigner" Meme: Interpreting The Application Of Federal Court Interpreter Laws, Leslie V. Dery

Florida Law Review

No abstract provided.


Ignoring Distress Signals: Why Courts Should Recognize Emotional Distress Damages In Wrongful Adoption Claims, Erica Shultz Jul 2022

Ignoring Distress Signals: Why Courts Should Recognize Emotional Distress Damages In Wrongful Adoption Claims, Erica Shultz

Florida Law Review

No abstract provided.


Is Diversity A Value In American Higher Education?, Anthony T. Kronman Jul 2022

Is Diversity A Value In American Higher Education?, Anthony T. Kronman

Florida Law Review

No abstract provided.


When Is A Man A Man, And When Is A Woman A Woman?, Julie A. Greenberg Jul 2022

When Is A Man A Man, And When Is A Woman A Woman?, Julie A. Greenberg

Florida Law Review

No abstract provided.


Constitutional Codification Of An Environmental Ethic, John C. Tucker Jul 2022

Constitutional Codification Of An Environmental Ethic, John C. Tucker

Florida Law Review

No abstract provided.


Off-Label Use, Prescription, And Marketing Of Fda-Approved Drugs: An Assessment Of Legislative And Regulatory Policy, Steven R. Salbu Jul 2022

Off-Label Use, Prescription, And Marketing Of Fda-Approved Drugs: An Assessment Of Legislative And Regulatory Policy, Steven R. Salbu

Florida Law Review

No abstract provided.


Invasion Of Two Labidesthes Species Through The Tennessee-Tombigbee Waterway In Mississippi, Benjamin H. Chaffins, Calvin R. Rezac, Robert J. Ellwanger Jul 2022

Invasion Of Two Labidesthes Species Through The Tennessee-Tombigbee Waterway In Mississippi, Benjamin H. Chaffins, Calvin R. Rezac, Robert J. Ellwanger

Southeastern Fishes Council Proceedings

We re-identified the collections of Labidesthes sicculus at Mississippi Museum of Natural Science after a 2015 publication by Werneke and Armbruster elevated Labidesthes vanhyningi to the full species level. Following re-examination of specimens, 64% were identified as L. vanhyningi and 36% were identified as L. sicculus. During our study, a chronological review of the distribution of both species suggested bi-directional invasion through the Tennessee-Tombigbee Waterway. Prior to the connection of the two drainages, the only Labidesthes located in the Tennessee drainage was L. sicculus, where as L. vanhyningi was allopatric within the Tombigbee drainage. However, following canal construction, we …


Sport Chaplains And Social Workers: A Theoretical Understanding Of A Necessary Component Of An Interprofessional Collaborative Practice In Sport In The United States, Lauren Beasley Phd, Ms, Lmsw, Emily J. Johnson Mph, Ms, Steven N. Waller Phd, Dmin, Cspc Jul 2022

Sport Chaplains And Social Workers: A Theoretical Understanding Of A Necessary Component Of An Interprofessional Collaborative Practice In Sport In The United States, Lauren Beasley Phd, Ms, Lmsw, Emily J. Johnson Mph, Ms, Steven N. Waller Phd, Dmin, Cspc

Movement and Being: The Journal of the Christian Society for Kinesiology, Leisure and Sports Studies

Holistic care of athletes is a growing area of research and practice. Yet, there is still much to consider as attention to this matter continues to expand. Specifically, what are the different theoretical perspectives of each profession working together towards the holistic care of athletes? The theoretical understanding between professions is essential for effective interprofessional teams—what some scholars have termed interprofessional cultural competence. The purpose of this paper is thus to provide the theoretical underpinnings for collaboration between sport chaplains and social workers, both emerging professions within interprofessional care in sport. This paper presents the unique partnership of sport chaplains …


Counter-Majoritarian Power And Judges' Political Speech, Michael Richard Dimino Sr. Jul 2022

Counter-Majoritarian Power And Judges' Political Speech, Michael Richard Dimino Sr.

Florida Law Review

No abstract provided.