Digital Commons Network^™

Consequences Of Caring: The Manifestation Of Compassion Fatigue In High School Teachers During The Covid-19 Pandemic, Randi Staggs

Electronic Theses and Dissertations

The purpose of this research study was to explore the symptoms of compassion fatigue as experienced by teachers in grades 9-12 during the COVID-19 pandemic. While the research on the effects of compassion fatigue on educators is relatively sparse, the literature regarding compassion fatigue, secondary traumatic stress, and vicarious trauma in other helping professions revealed a 12-symptom framework.

Data collection strategies included individual virtual interviews and field notes. Analysis of data occurred in four phases: (a) analyzing transcripts and identifying themes, (b) categorization of data under the 12 symptoms of compassion fatigue, (c) building the explanation in narrative form, and …

Reconstructive Outcomes Of Multilayered Closure Of Large Skull Base Dural Defects Following Open Anterior Craniofacial Resection, Justin Shi, Tokunbo Ayeni, Kathleen Kelly Gallagher, Akash J Patel, Ali Jalali, David J Hernandez, Angela D Haskins, Vlad C Sandulache, Erich M Sturgis, Andrew T Huang

Faculty, Staff and Students Publications

Introduction  Standardized reconstruction protocols for large open anterior skull base defects with dural resection are not well described. Here we report the outcomes and technique of a multilayered reconstructive algorithm utilizing local tissue, dural graft matrix, and microvascular free tissue transfer (MVFTT) for reconstruction of these deformities.

Design  This study is a retrospective review.

Results  Eleven patients (82% males) met inclusion criteria, with five (45%) having concurrent orbital exenteration and eight (73%) requiring maxillectomy. All patients required dural resection with or without intracranial tumor resection, with the average dural defect being 36.0 ± 25.9 cm ² . Dural graft matrices …

Genetic Determinants Of Metabolic Biomarkers And Their Associations With Cardiometabolic Traits In Hispanic/Latino Adolescents, Daeeun Kim, Anne E. Justice, Geetha Chittoor, Estela Blanco, Marcio Almeida, Juan M. Peralta, Donna M. Lehman, Joanne E. Curran, Anthony G. Comuzzie, Ravi Duggirala, John Blangero

School of Medicine Publications

Background: Metabolic regulation plays a significant role in energy homeostasis, and adolescence is a crucial life stage for the development of cardiometabolic disease (CMD). This study aims to investigate the genetic determinants of metabolic biomarkers-adiponectin, leptin, ghrelin, and orexin-and their associations with CMD risk factors.

Methods: We characterized the genetic determinants of the biomarkers among Hispanic/Latino adolescents of the Santiago Longitudinal Study (SLS) and identified the cumulative effects of genetic variants on adiponectin and leptin using biomarker polygenic risk scores (PRS). We further investigated the direct and indirect effect of the biomarker PRS on downstream body fat percent (BF%) and …

An Investigation Of The Yidc-Mediated Membrane Insertion Of Pf3 Coat Protein Using Molecular Dynamics Simulations, Adithya Polasa, Jeevapani Hettige, Kalyan Immadisetty, Mahmoud Moradi

Chemistry & Biochemistry Faculty Publications and Presentations

YidC is a membrane protein that facilitates the insertion of newly synthesized proteins into lipid membranes. Through YidC, proteins are inserted into the lipid bilayer via the SecYEG-dependent complex. Additionally, YidC functions as a chaperone in protein folding processes. Several studies have provided evidence of its independent insertion mechanism. However, the mechanistic details of the YidC SecY-independent protein insertion mechanism remain elusive at the molecular level. This study elucidates the insertion mechanism of YidC at an atomic level through a combination of equilibrium and non-equilibrium molecular dynamics (MD) simulations. Different docking models of YidC-Pf3 in the lipid bilayer were built …

Statins: Masked Anti-Epileptic Warriors, Govinda Khatri, Priya Kotak, Ayush Kumar, Mohammad Mehedi Hasan

Medical College Documents

No abstract provided.

"Religion, Culture, And The Monstrous: Of Gods And Monsters"[Review]/Mikles, Natasha L., And Joseph P. Laycock, Eds, Nathaniel Gibbs

Andrews University Seminary Studies (AUSS)

This is a book review by Nathaniel Gibbs.

A Quantitative Study On The Predictive Ability Of Mcat Scores On The Pre-Clinical Grade Point Averages Of Black Medical Students, Bennetta Horne

LSU New Orleans Theses and Dissertations

The purpose of this study was to examine the predictive ability of MCAT scores on the pre-clinical grade point averages of Black medical students. Underrepresented in medicine students, including students of color and those from low socioeconomic backgrounds have often been prevented from pursuing medical education. This is due to the heavy reliance on numeric metrics including undergraduate grade point averages and MCAT scores for admissions decisions. (DeCarvalho et al., 2018; Linville, 2015; Reede, 1999). The research questions employed in this study focused on the relationship between MCAT scores and pre-clinical grades of Black students and the relationship between secondary …

Selinexor In Advanced, Metastatic Dedifferentiated Liposarcoma: A Multinational, Randomized, Double-Blind, Placebo-Controlled Trial, Mrinal M Gounder, Brian A Van Tine, Et Al

2020-Current year OA Pubs

PURPOSE: Antitumor activity in preclinical models and a phase I study of patients with dedifferentiated liposarcoma (DD-LPS) was observed with selinexor. We evaluated the clinical benefit of selinexor in patients with previously treated DD-LPS whose sarcoma progressed on approved agents.

METHODS: SEAL was a phase II-III, multicenter, randomized, double-blind, placebo-controlled study. Patients age 12 years or older with advanced DD-LPS who had received two-five lines of therapy were randomly assigned (2:1) to selinexor (60 mg) or placebo twice weekly in 6-week cycles (crossover permitted). The primary end point was progression-free survival (PFS). Patients who received at least one dose of …

Design, Synthesis And Characterization Of Triazole Based Glycoconjugates And 4,6-Acetal Protected D-Glucosamine Derivatives As Low Molecular Weight Gelators, Pooja Sharma

Chemistry & Biochemistry Theses & Dissertations

Low molecular weight gelators (LMWGs) are small molecules that can form gels in either organic solvents or water in their pure form or as mixtures. LMWGs self-assemble through noncovalent interactions such as hydrogen bonding, halogen bonding, van der Waals interactions and hydrophobic forces in solvents. They have shown great potential in biomedical industry, catalysis and environmental remediation to name a few. Moreover, the formation of metallogels can be used for detection of various ions as well as catalysis, which adds a new dimension to their applications. Among many classes of LMWGs based on the type of functional groups used, carbohydrate …

Engineering Of Ideal Systems For The Study And Direction Of Stem Cell Asymmetrical Division And Fate Determination, Martina Zamponi

Biomedical Engineering Theses & Dissertations

The cellular microenvironment varies significantly across tissues, and it is constituted by both resident cells and the macromolecules they are exposed to. Cues that the cells receive from the microenvironment, as well as the signaling transmitted to it, affect their physiology and behavior. This notion is valid in the context of stem cells, which are susceptible to biochemical and biomechanical signaling exchanged with the microenvironment, and which plays a fundamental role in establishing fate determination and cell differentiation events. The definition of the molecular mechanisms that drive stem cell asymmetrical division, and how these are modulated by microenvironmental signaling, is …

Investigating The Biorisk Of Genetically Engineered Thermosynechococcus Elongatus Bp1, Cherrelle Leah Barnes

Chemistry & Biochemistry Theses & Dissertations

Cyanobacteria, also known as blue-green algae, are an ancient group of microorganisms that use simple materials, such as sunlight, carbon dioxide and water, to produce energy while providing oxygen to the atmosphere by performing photosynthesis. Synthetic biology approaches have been employed with cyanobacteria as a platform to produce a range of products, such as biofuels, by inserting a series of genes into the cyanobacterial genome that will allow the conversion of metabolic intermediates to such desired products. Although these methods are promising, it is important to understand any potential bio-risk they pose. This research evaluates the potential bio-risk of genetically …

Brain Electrophysiology In The Presence Of Acoustic Stimuli, Kristen Howorka

McKelvey School of Engineering Graduate Student Theses & Dissertations

Neuroscience is the study of the structure and function of the brain. This is inclusive of neurochemistry, physiology, anatomy, molecular biology, computer science, engineering and many adjacent disciplines. While there have been a multitude of studies in this field, there are still so many questions left unanswered about the brain. One such question pertains to how animals and humans perceive stimuli from the environmental periphery, a neuroscience sub-area known as sensory processing.

By design, humans have neurological states and receptors which organically take in all of these stimuli and decipher them for everyday needs. Sensory input enables subjects to perform …

Selective Recovery Of Rare Earth Elements Using A Hydroxyapatite-Chitosan Composite, Zixuan Xie

McKelvey School of Engineering Graduate Student Theses & Dissertations

Rare earth elements (REEs) have special properties that make them extremely important in modern clean energy technology. With rising global demand and increasing supply risks, sustainable use of rare earth resources is increasingly imperative. Coal fly ash is a promising source for recovering REEs, but the coexistence of large amounts of non-target elements requires recovery materials with a high preference for REEs. For this recovery study, we found that hydroxyapatite (HAP) that has high density of phosphate groups is efficient in selective REE recovery. The addition of chitosan (CS) as a binder increased the mechanical stability of composites and their …

The Effects Of Host-Like Environmental Signals And Gene Expression On Capsule Growth In Cryptococcus Neoformans, Yu Min Jung

McKelvey School of Engineering Graduate Student Theses & Dissertations

Cryptococcus neoformans is a fungal pathogen that causes cryptococcosis, a disease that kills almost 200,000 people worldwide each year. A unique feature of this deadly yeast is its polysaccharide capsule, which is known to be associated with its virulence. Here, we systematically explore the effects of all possible combinations of 4 capsule-inducing signals on gene expression, cell size, and capsule size. These signals are medium (YPD, DMEM or RPMI), temperature (30°C or 37°C), CO₂ (room air or 5%), cAMP (0 mM or 20 mM), and pH buffer (HEPES/no HEPES). We explore the effects of exogenous cAMP at a range …

In Vitro Blood Clot Formation And Dissolution For Testing New Stroke-Treatment Devices, Kayla Wood, Sam E. Stephens, Feng Xu, Alshaimaa Hazaa, James C. Meek, Hanna K. Jensen, Morten O. Jensen, S. Ranil Wickramasinghe

Biomedical Engineering Faculty Publications and Presentations

Strokes are among the leading causes of death worldwide. Ischemic stroke, due to plaque or other buildup blocking blood flow to the brain, is the most common type. Although ischemic stroke is treatable, current methods have severe shortcomings with high mortality rates. Clot retrieval devices, for example, can result in physically damaged vessels and death. This study aims to create blood clots that are representative of those found in vivo and demonstrate a new method of removing them. Static blood clots were formed using a 9:1 ratio of whole sheep blood and 2.45% calcium chloride solution. This mixture was heated …

Incorporating Immersive Learning Into Biomedical Engineering Laboratories Using Virtual Reality, Megan Wilkerson, Vitali V. Maldonado, Srikanth Sivaraman, Raj R. Rao, Mostafa Elsaadany

Biomedical Engineering Faculty Publications and Presentations

Background

The Covid-19 pandemic caused a sudden shift towards remote learning, moving classes to online formats. Not exempt from this switch, laboratory courses traditionally taught in-person were also moved to remote methods, costing students the opportunity to learn these skills hands-on. In order for instructors to provide course materials effectively and engagingly, non-traditional methods should be explored.

Virtual reality (VR) has become more accessible in recent years. VR simulations have been used for many years as educational tools in high-risk settings such as flight or medical simulations. Immersive VR videos implemented in a remote laboratory course could provide the students …

Effect Of Irrigation Regime And Fertilization On Recovery Of Dicamba Injured Soybean, Wesley France, Jason K. Norsworthy, Trenton Roberts, Jeremy Ross, L. Tom Barber, Edward E. Gbur

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

With the release of the dicamba-resistant crop technology and subsequent increase in dicamba off-target movement to non-dicamba-resistant crops, discovering means of mitigating yield loss through studying dicamba injury to soybean and interactions with factors such as irrigation regime and fertilization would prove beneficial. Field experiments were conducted in 2019 in Fayetteville and Colt, Arkansas, to evaluate the effect of irrigation regime to non-dicamba-resistant soybean that was injured by dicamba at a low dose at multiple timings. Another experiment was conducted in Fayetteville in 2019 and 2020 evaluating the impact of nitrogen (N) and potassium (K) fertilization on soybean recovery following …

Optimal Design Of Functionally Graded Parts, Priyambada Nayak, Amir Armani

Faculty Research, Scholarly, and Creative Activity

Several additive manufacturing processes are capable of fabricating three-dimensional parts with complex distribution of material composition to achieve desired local properties and functions. This unique advantage could be exploited by developing and implementing methodologies capable of optimizing the distribution of material composition for one-, two-, and three-dimensional parts. This paper is the first effort to review the research works on developing these methods. The underlying components (i.e., building blocks) in all of these methods include the homogenization approach, material representation technique, finite element analysis approach, and the choice of optimization algorithm. The overall performance of each method mainly depends on …

Emergent Landscapes Of Renewable Energy Storage: Considering Just Transitions In The Western United States, Bethani Turley, Alida Cantor, Kate Berry, Sarah Knuth, Dustin Mulvaney, Noel Vineyard

Geography Faculty Publications and Presentations

Governments, utilities, and energy companies are increasingly looking towards energy storage technologies to extend the availability of variable renewable power sources such as solar and wind. In this Perspective, we examine these fast-shifting developments by mapping and analyzing landscapes of renewable energy storage emerging across the Western United States. We focus on the rollout of several interrelated leading technologies: utility-scale lithium-ion batteries, supported by increasing regional lithium mining, and proposals for new pumped storage hydropower. Drawing on critical resource geography, we examine energy storage as both a component of renewable transition and as its own driver of landscape transformation, resource …

Glucose Uptake By Glut1 In Photoreceptors Is Essential For Outer Segment Renewal And Rod Photoreceptor Survival, Lauren L. Daniele, John Y.S. Han, Ivy S Samuels, Ravikiran Komirisetty, Nikhil Mehta, Jessica L Mccord, Minzhong Yu, Yekai Wang, Kathleen Boesze-Battaglia, Brent A Bell, Jianhai Du, Neal S Peachey, Nancy J. Philp

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Photoreceptors consume glucose supplied by the choriocapillaris to support phototransduction and outer segment (OS) renewal. Reduced glucose supply underlies photoreceptor cell death in inherited retinal degeneration and age-related retinal disease. We have previously shown that restricting glucose transport into the outer retina by conditional deletion of Slc2a1 encoding GLUT1 resulted in photoreceptor loss and impaired OS renewal. However, retinal neurons, glia, and the retinal pigment epithelium play specialized, synergistic roles in metabolite supply and exchange, and the cell-specific map of glucose uptake and utilization in the retina is incomplete. In these studies, we conditionally deleted Slc2a1 in a pan-retinal or …

Growing Concerned: How Societal Stress Relates To Plants In The Home, Trenton W. Birdwell

Electronic Theses and Dissertations

Design trends are constantly in flux, but the reasons why people prefer new trends are not readily apparent. This thesis brought together multiple aspects of interior design to investigate how design has changed. After a review of available studies, the researcher decided to focus on natural design in homes because this area has previous research upon which to build. This study compared data to examine how stress in America relates to plant imagery. The research questions asked what, if any, relationship exists between societal stress and the use of plants, plant-like objects, and window views.

Measures of stress included hospitalization, …

Light Directed Targeted Photodynamic Therapy Of Breast Cancer, Sara Shaut

Theses

Breast cancer is the most prevalent cancer among women besides non-melanoma skin cancer. Even when caught in early stages, the treatment for breast cancer is often accompanied by harsh and debilitating side effects. For better quality of life, treatment options that have minimal side effects but maintain effectiveness are invaluable. If such a treatment option is a targeted form of therapy, it could selectively treat cancerous cells and not healthy cells. Photodynamic therapy (PDT) is a relatively new light-based therapy that utilizes inherent photochemical properties of certain dyes called photosensitizers (PS) in order to kill cancerous cells. It shows great …

Synthesis Of Modular Do3a-Based High-Relaxivity Contrast Agents For Mri Of Prostate Cancer, Dana Qiang Murphy Soika

Theses

Contrast agents (CAs) are small molecules used in magnetic resonance imaging (MRI) to help diagnose various forms of cancer. While MRI is advantageous over other clinical imaging techniques, limitations of today’s contrast agents containing gadolinium (Gd) hinder their safety, sensitivity, and specificity. The conventional CAs that MRI relies on are considered low-relaxivity and are not optimally effective at enhancing MR signal. Additionally, they lack cell-specificity and circulate throughout the body. Furthermore, unbound Gd3+ is nephrogenic which prevents its use in patients with impaired renal function. In the clinic, these limitations mean high dosages of these compounds must be administered to …

The Right To The University: The Experiences Of Mexican/Mexican American/Xicanx Students At A Predominantly White University In Upstate New York, Martín Alberto Gonzalez

Chicano/Latino Studies Faculty Publications and Presentations

Having the right to a space is not only the right to be present without being harassed or bothered, but it also includes the right to have a say in how that space should be experienced. Yet, spaces have long been contested and not everyone has equal access to shared spaces. This paper examines the experiences of Mexican/Mexican American/Xicanx (MMAX) undergraduate students at a predominantly white university in the Northeast. Drawing on indepth interviews, participant observations, pláticas, and document analyses, I argue that MMAX students do not have the right to their respective university because their university does not address …

Circulating Trophoblast Numbers As A Potential Marker For Pregnancy Complications, Brielle Crovetti, Mohamad Ali Maktabi, Hadi Erfani, Tachjaree Panchalee, Qun Wang, Liesbeth Vossaert, Ignatia Van Den Veyver

Center for Medical Ethics and Health Policy Staff Publications

Objective: To explore the potential of circulating trophoblasts (TBs) as a non-invasive tool to assess placental health and predict obstetric complications.

Methods: We retrospectively reviewed maternal characteristics and pregnancy outcomes of 369 women who enrolled in our original cell-based NIPT (cbNIPT) study. The number of circulating TBs recovered from the maternal blood samples was recorded and expressed as fetal cell concentration (FCC). We evaluated if FCC can be used to predict pregnancy outcomes such as hypertensive disorders of pregnancy (HDP), fetal growth restriction, placental abruption, preterm labor, and pregnancy loss.

Results: Receiver operating characteristic (ROC) analysis was performed to find …

No History Or Society To Be Found: Object-Oriented Ontology And Social Ontology, Bennett B. Gilbert

University Studies Faculty Publications and Presentations

It is widely theorized that the advent of the “Anthropocene Age” (under this or any other name) is bringing one form of human temporality to an end while it initiates another (Simon 2021). Because human activity threatens the duration and well-being of the planetary biosphere, the new age that this activity is bringing on—though it is proving to be extremely difficult to define—does present specific onto-epistemological and moral challenges behind its political and social problems. The most prominent and perhaps the core of these challenges is the demand to shed anthropocentrism in human culture, a change that would deeply alter …

Science Education Research On Student To Student Discourse: A Literature Review With An Applied Linguistics Lens, Abbee A. Mortensen

University Honors Theses

Science education researchers have increasingly been using discourse analysis to research small group discussion while doing course related activities. This literature review examined studies from that discourse community to see what analysis methods were used and if they connected to applied linguistics theories or methods. Two of the most common discourse analysis frameworks used were Toulmin's Argument Pattern and grounded coding schemes that looked at the design and specific contents of the discourse. Studies covered will also include education scholars using theories of conversation analysis and normative pragmatics to make a more explicit connection to applied linguistics. Orienting and drawing …

Together Or Apart? The Effects A Parent's Relationship Dynamic Has On Their Child(Ren)'S Romantic Relationship, Kailee Delos Santos

University Honors Theses

The relationship between parents is considered one of the most influential interactions a child will experience; as it is usually the first relationship a child witnesses where personal values and interests develop (Stanger, 2019). Nonetheless, it is a consistently understudied population in family research and, when studied, children are primarily examined during adolescence and often only in the context of conflict and rivalry. Additionally, much of this research does not examine the effects of a child's romantic relationship on the larger family system. This thesis seeks to address this gap in the literature by understanding how the relationship of a …

Lifetime Racism And John Henryism On Cognition And Cardiovascular Health In Black Men, Roy Mitchell

Dissertations

Lifetime racism is a type of chronic stress that is often accompanied by depression. Racism is the experience of many Black men because of several psychosocial stressors such as reduced resources and institutional barriers, to name a few. Active coping is typically utilized by Black men as a consistent means to reduce the negative outcomes linked to racism, however, this up-tempo coping style can contribute to poor cardiovascular health and cognitive impairment over time. The present study aimed to provide data to support the effects of lifetime racism and active coping on cardiovascular health and cognition. There were three hypotheses …

“Family Before Anyone Else”: A Qualitative Study On Family, Marginalization, And Hiv Among Hispanic Or Latino/A/X Mexican Sexual Minority Males, Moctezuma García, S. Raquel Ramos, Lisa Aponte-Soto, Tiarney D. Ritchwood, Laurie A. Drabble

Faculty Research, Scholarly, and Creative Activity

This study explored the influence family relationships have on HIV-related factors among Hispanic or Latino/a/x Mexican sexual minority cisgender males in San Antonio, TX, US. A total of 15 young adults (7 people living with HIV; PLWH) ages 21–30 completed a semi-structured interview. Data were transcribed verbatim and analyzed using thematic analysis. The following themes emerged: (1) family support; (2) mother-son relationships; (3) father-son relationships; (4) sibling support; (5) family marginalization of sexual minorities; and (6) internalized homophobia. People who reported being HIV negative were more likely to have a prominent mother-son relationship, strong sense of family, supportive siblings, and …