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Biological Activities Of Ya-Mor-Noi Remedy For Postpartum Care, Jaiboonya Jaicharoensub, Intouch Sakpakdeecharoen, Sumalee Panthong,, Arunporn Itharat

Asian Medical Journal and Alternative Medicine

Introduction: Ya-Mor-Noi (YMN) is a Thai herbal remedy used at Dansai Crown Prince Hospital, Loei Province. It consists of seven plants, including the rhizome of Smilax corbularia (SC), the stem of Caesalpinia sappan (CS), Goniothalamus laoticus (GL), Polyalthia suberosa (PS), Glycosmis pentaphylla (GP), Croton persimilis (CP), and Diospyros ehretioides (DE). For over 20 years, YMN has been prescribed for patients admitted to post-partum wards after delivery to efficiently reduce inflammation and rehabilitate them.

Objectives: To study biological activities of YMN extracts relating to postpartum conditions, including anti-inflammatory, wound healing activities and investigating its main compound.

Methods: Extraction methods comprised …

Fucoxanthin Attenuates Hydrogen Peroxide-Induced Oxidative Stress In Placenta-Derived Mesenchymal Stem Cells Through Antioxidant Activity, Gunticha Suwanmanee, Chairat Tantrawatpan, Pakpoom Kheolamai, Duangrat Tantikanlayaporn, Sirikul Manochantr

Asian Medical Journal and Alternative Medicine

Introduction: Osteoporosis is a bone disease that results in a loss of bone mass. Oxidative stress promotes osteoblast apoptosis which leads to decrease bone formation. Fucoxanthin, a carotenoid extracted from brown seaweeds, has antioxidant activity through an increased antioxidant enzyme expression.

Objectives: This study attempts to explore the cytoprotective effect and antioxidant activity of fucoxanthin to promote the cell viability of placenta-derived mesenchymal stem cells (PL-MSCs) under oxidative stress conditions.

Methods: PL-MSCs were obtained from a pregnant woman after normal delivery. Following the characterization, PL-MSCs were treated with fucoxanthin (1-5 µM) and 750 µM H₂ O₂ for 24 …

The Expression Of Alkaline Phosphatase In Metformin-Treated Umbilical Cord-Derived Mesenchymal Stem Cells, Nuengruethai Chadee, Jintamai Suwanprateep, Chairat Tantrawatpan, Pakpoom Kheolamai, Duangrat Tantikanlayaporn, Sirikul Manochantr

Asian Medical Journal and Alternative Medicine

Introduction: Mesenchymal stem cells (MSCs) have gained more interest in regenerative medicine. The umbilical cord, the alternative source of MSCs, has thus been increasingly recognized as a good MSC source for bone tissue regeneration and bone defect repair. Metformin, an anti-hyperglycemic drug, has been reported that promotes the osteogenic differentiation of BM-MSCs.
Objectives: This study aims to investigate the viability and the expression of alkaline phosphatasein metformin-treated umbilical cord-derived MSCs (UC-MSCs) during osteogenicdifferentiation.
Methods: The UC-MSCs were obtained from pregnant women after normal delivery. After charac-terization, UC-MSCs were cultured with different metformin concentrations (0 - 160 μM). The cell viability …

Andrographolide Promotes Osteoblastic Differentiation In Mc3t3-E1 Cells And Protects Bone Loss In Estrogen Deficiency Rats, Duangrat Tantikanlayaporn, Patsorn Wichit, Apichart Suksamrarn, Pawinee Piyachaturawat

Asian Medical Journal and Alternative Medicine

Introduction: A decline of estrogen in menopause women is accompanied with increases in many pro-inflammatory cytokines and osteoporosis. Andrographolide (AP), from Andrographis paniculata, which has an anti-inflammatory activity, may have potential to alleviate osteoporosis during estrogen deficiency.
Objectives: This study aimed to investigate the osteogenic potential of AP on mouse pre-osteoblastic (MC3T3-E1) cells and the protective effect of AP on bone loss in estrogen-deficient rats.
Methods: The study was conducted into two parts. Firstly, in mouse pre-osteoblastic (MC3T3-E1)
cells, the osteogenic effect of AP was determined by ALP expression, alizarin red staining, and osteoblast-specific gene expressions. Secondly, the protective …

Diarylheptanoid From Curcuma Comosa Increases Osteoblast Differentiation Ability Of Human Umbilical Cord-Derived Mesenchymal Stem Cells, Moe Moe Paing, Pakpoom Kheolamai, Sirikul Manochantr, Duangrat Tantikanlayaporn

Asian Medical Journal and Alternative Medicine

Introduction: Mesenchymal stromal cells (MSCs) have shown a promise in the treatment of degenerative diseases. Recently, human umbilical cord-derived MSCs (hUC-MSCs) have attracted more interests because they can be easily obtained by a non-invasive procedure. hUC-MSCs can differentiate into osteoblasts in like MSCs derived from bone marrow (BM-MSCs). However, the ability is inefficient when compared with BM-MSCs. Therefore, efforts to increase the osteogenic potential of UC-MScs would be a significant step forward in regenerative medicine.
Objectives: We examined the osteogenic effect of a diarylheptanoid, 7-(3, 4-dihydroxy-phenyl)-5-hydroxy-1-phenyl-(1E)-1-heptene from Curcuma comosa (compound 092) on hUC-MSCs.
Methods: Mesenchymal stem cells were isolated from …

Library Directors Of Csb And Sju: A Brief History, Peggy L. Roske

Archives History Lessons

No abstract provided.

Proceedings Of The 2022 Berry Summer Thesis Institute, University Of Dayton. University Honors Program

Proceedings of the Berry Summer Thesis Institute (2013-Present)

Thanks to a gift from the Berry Family Foundation and the Berry family, the University Honors Program launched the Berry Summer Thesis Institute in 2012. The institute introduces students in the University Honors Program to intensive research, scholarship opportunities and professional development. Each student pursues a 12-week summer thesis research project under the guidance of a UD faculty mentor. This contains the product of the students' research.

Thesis projects from 2022 include:

“Musical Expressions and Symbolic Forms,” by Jacob Biesecker-Mast

“Lovecraft, the Uncanny, and The Sublime: A Psychoanalytic Critique of H.P. Lovecraft's Fiction,” by Jules Carr-Chellman

“Critical Review of Literature …

Evaluating Traditional And Novel Modalities Of Self-Monitoring In Females With Low-Literacy & Obesity: A Feasibility Study, Anita H. Kelleher

Master's Theses

This study aimed to determine the feasibility of three distinct self-monitoring modalities employed as part of a weight-loss intervention among Spanish- and Mixtec-speaking women with low-no literacy who were overweight or obese (body mass index, BMI> 25). Primary outcomes assessed include self-monitoring adherence, weight, body composition, and diet quality. Participants (n=18) were recruited from the Cal Poly Women and Infants Mobile Health Unit, and contacted if they had a BMI> 25 and did not attend school beyond elementary level (6th grade). Upon enrollment, participants were asked to attend a weekly meeting at which the lifestyle intervention was delivered by a …

Ab 691 Synthesis Report, California State Lands Commission

State & Federal Reports and Publications

Since the passage of AB 691, the Commission has worked closely with the trustees by providing resources and guidance to address challenges they encountered while developing the assessments. This report aims to meet the goals including a synthesis of the trustees’ AB 691 assessments followed by a set of recommendations to provide local and state decision makers with effective short- and long-term policy goals, strategies, and targeted assistance that is responsive to the trustees’ real-world challenges.

Investigations Into Avian Skeletal Adaptations And Spine Fusion Events, Tori Huey

All Theses

Avian dinosaurs evolved skeletal adaptations resulting in numerous fused spinal structures, like the synsacrum, present in extant birds. The synsacrum is a highly fused region necessary for stiffening the spine, and it fuses the spine to the pelvic ilium. Conventional wisdom suggests that fusion occurred in ovo during embryonic development via the cartilage matrix that patterns the future vertebrae. We show that post hatch birds have intervertebral discs separating all vertebrae of the spine, leading us to re-examine this notion in chickens up to 10 weeks of age. Intervertebral discs undergo constant remodeling, then degenerate and undergo tissue clearance, followed …

Prototype For A Rural Primary Healthcare Center In Paraguay, Maria Virginia Matiauda Schneider

All Theses

Primary Health Care Centers in Paraguay are the architectural settings for the first level of access to healthcare in Paraguay, providing health promotion, pre- vention, diagnosis, treatment, and health education. These centers are built based on four standard typologies, of which two consist of permanent health- care facilities and two of satellite or mobile units. Standard designs for these centers typically consist of residential scaled buildings, with spaces linked by a single central circulation corridor and lacking adequate attention to ventilation and daylight.

The public healthcare system in Paraguay is organized around four levels of care, and the complexity and …

Machine Learning Model Comparison And Arma Simulation Of Exhaled Breath Signals Classifying Covid-19 Patients, Aaron Christopher Segura

Mathematics & Statistics ETDs

This study compared the performance of machine learning models in classifying COVID-19 patients using exhaled breath signals and simulated datasets. Ground truth classification was determined by the gold standard Polymerase Chain Reaction (PCR) test results. A residual bootstrapped method generated the simulated datasets by fitting signal data to Autoregressive Moving Average (ARMA) models. Classification models included neural networks, k-nearest neighbors, naïve Bayes, random forest, and support vector machines. A Recursive Feature Elimination (RFE) study was performed to determine if reducing signal features would improve the classification models performance using Gini Importance scoring for the two classes. The top 25% of …

Genome Sequence Of The Estuarine Synechococcus Sp. Strain Nb0720_010, Campbell A. Mackenzie, Marcia F. Marston, Javier F. Tabima, Nathan A. Ahlgren

Arts & Sciences Faculty Publications

Synechococcus spp. are unicellular cyanobacteria widely distributed in the world's oceans. We report the complete genome sequence of Synechococcus sp. strain NB0720_010, isolated from Narragansett Bay, Rhode Island. NB0702_10 has several large (.3,000-amino acid) protein-coding genes that may be important in its interactions with other cells, including grazers in estuarine habitats.

Understanding Dynamics Of Polymers Under Confinement: A Molecular Dynamics And Neutron Scattering Study, Supun Samindra Kamkanam Mohottalalage

All Dissertations

The current study probes the structure, dynamics, and rheological behavior of associating polymers including ionomers in melts and solutions as well as conjugated polymers confined into nanoparticles, using molecular dynamics (MD) simulations and neutron scattering techniques. The study focuses on two families of associative polymers, ion containing macromolecules and conjugated polymers.

Polymers that consist of ionizable groups along their backbone found uses in a broad range of applications. Examples include light weight energy storage and generation systems, and biomedical applications, where the polymers act as ion exchange membranes, and actuators. The ionic groups tend to form clusters that are in …

Let Them Eat Rights: Re-Framing The Food Insecurity Problem Using A Rights-Based Approach, Benedict Sheehy, Ying Chen

Michigan Journal of International Law

Food insecurity is a global issue. Large parts of the global population are unable to feed themselves adequately with hundreds of millions of people suffering from hunger and malnutrition. This problem is recognized widely by governments, industry and civil society and is usually understood using one of three approaches or frames: a basic production problem solved by technology and increased industrialization of agricultural, and an economic problem solved by economic growth and a commercial problem resolved by expanding markets. Much of the discussion and policy advice is based on the premise that hunger is primarily a wealth issue and, that …

Social Distance, Stigma, And Help-Seeking: A Comparison Of Lay And Professional Conceptualizations Of Autism In The Southern Us, Christian Shannon Courson

Electronic Theses and Dissertations

Understanding stigma, help-seeking and barriers to treatment for persons with Autism Spectrum Disorder (ASD) is essential for informing interventions toward increased relevance and utility. An array of sociocultural and individual factors can influence lay beliefs and behavioral responses to ASD, including stigma and social distancing (i.e., preference for distance from autistic individuals). It is important to consider the Explanatory Models of ASD among helping professionals (e.g., health care, education) as they are likely touchstones along the help-seeking pathway for children with ASD. The purpose of this study was twofold: 1) to explore factors in the southern United States associated with …

The Ongoing Collegiate Anxiety Pandemic: It’S A Dangerous Business Going Out Your Front Door, Daniel Pineau

Electronic Theses and Dissertations

Anxiety is an emotion that consists of worrisome thoughts, physical tension, and physiological arousal regarding the perceived potential of danger. College students have increasingly endorsed anxiety as a primary difficulty during the collegiate years. Due to this increase in anxiety and an increase in utilization of therapy services, the overall study aim was to identify the factors that influence anxiety presentations and whether or not a brief, online, therapeutic intervention could be effective for symptom reduction. A group of participants (N = 96) volunteered to complete a longitudinal study providing a brief, online, psychological intervention through the University of Mississippi. …

Impact Of Institutional Support For Research And Development At An R1 University, Joy Tatum Shideler

Electronic Theses and Dissertations

This study utilizes a correlational research design to identify the relationship, if any, between institutional and external support of research and development (R&D) at an R1 University Carnegie Classification of Institutions of Higher Education R1: Very High Research Activity Doctoral University in the southeastern United States of America. Initial analyses of institutional and external R&D expenditures as reported in the National Science Foundation (NSF) Higher Education Research and Development (HERD) Survey from 2015 through 2020 did not identify any relationships between institutionally and externally funded R&D expenditures. Additionally, initial regressions were directionally split with positive correlations in 14 fields and …

Profile Of Commercialized Aphicides On The Survivorship And Feeding Behavior Of The Cotton Aphid, Aphis Gossypii, Flinn M. O'Hara, Jeffrey A. Davis, Daniel R. Swale

Faculty Publications

The cotton aphid, Aphis gossypii Glover (Hemiptera: Aphididae), is one of the most destructive agricultural pests due to photosynthate removal and horizontal transmission of plant viruses. Horizontal transmission of plant viruses by aphids occurs during distinct feeding behavioral events, such as probing for non-persistent viruses or phloem feeding for persistent viruses. We employed toxicity bioassays and electrical penetration graph (EPG) methodology to compare toxicity and quantify changes to feeding behavior and toxicity of A. gossypii after exposure to commercialized aphicides. Commercialized aphicides containing flupyradifurone, sulfoxaflor, thiamethoxam, thiamethoxam + lambda cyhalothrin, and bifenthrin induced >90% aphid mortality within 4 h of …

Architecture And Agency For Equity In Areas Beyond National Jurisdiction, Lisa M. Campbell, Robin Fail, Rebecca Horan, Leslie Acton, Jeffrey E. Blackwatters

Faculty Publications

The United Nations (UN) Sustainable Development Goals (SDGs) and the UN Decade of Ocean Science for Sustainable Development (Ocean Decade) bring increased attention to various aspects of ocean governance, including equity. One of the Ocean Decade's identified challenges is to develop a sustainable and equitable ocean economy, but questions arise about how to conceptualize the multiple dimensions of equity in an ocean context. These questions become more complex as activities move away from coastal ecosystems and communities into off-shore Areas Beyond National Jurisdiction (ABNJ), where ocean resources are recognized simultaneously as unowned/open access and as common heritage. In this paper, …

The Need For A Framework Addressing The Temporal Aspects Of Fish Sperm Motility Leading To Community-Level Standardization, Harvey Blackburn, Leticia Torres, Yue Liu, Terrence R. Tiersch

Faculty Publications

Motility is a widely available parameter that can be used to assess sperm quality of aquatic species. Sperm from fishes with external fertilization usually undergo a dynamic and short-lived period of motility after activation. The common practice of assigning a single value at an arbitrary peak of motility presents challenges for reproducibility, community-level standardization, and comparisons across studies. This study aimed to explore statistical approaches to standardize motility reporting, and to develop an initial framework for community-level standards. Sperm samples from 14 zebrafish (Danio rerio) with a total of 21,705 cells were analyzed by use of computer-assisted sperm analysis with …

Icam-1 Abundance Is Increased In Pancreatic Islets Of Hyperglycemic Female Nod Mice And Is Rapidly Upregulated By Nf-Κb In Pancreatic B-Cells, Thomas M. Martin, Susan J. Burke, Heidi M. Batdorf, David H. Burk, Sujoy Ghosh, Samuel D. Dupuy, Michael D. Karlstad, J. Jason Collier

Division of Basic Science Faculty Publications

Type 1 diabetes (T1D) is classified as an autoimmune disease where pancreatic b-cells are specifically targeted by cells of the immune system. The molecular mechanisms underlying this process are not completely understood. Herein, we identified that the Icam1 gene and ICAM-1 protein were selectively elevated in female NOD mice relative to male mice, fitting with the sexual dimorphism of diabetes onset in this key mouse model of T1D. In addition, ICAM-1 abundance was greater in hyperglycemic female NOD mice than in age-matched normoglycemic female NOD mice. Moreover, we discovered that the Icam1 gene was rapidly upregulated in response to IL-1β …

Reply To G Taubes, Mi Friedman, And V Torres-Carot Et Al., Kevin D. Hall, I. Sadaf Farooqi, Jeffery M. Friedman, Samuel Klein, Ruth J.F. Loos, David J. Mangelsdorf, Stephen O’Rahilly, Eric Ravussin, Leanne M. Redman, Donna H. Ryan, John R. Speakman, Deirdre K. Tobias

Clinical Research Faculty Publications

No abstract provided.

Nutritional Quality Of Calorie Restricted Diets In The Calerie™ 1 Trial, Susan B. Racette, Valene Garr Barry, Connie W. Bales, Megan A. Mccrory, Kathleen A. Obert, Cheryl H. Gilhooly, Susan B. Roberts, Corby K. Martin, Catherine Champagne, Sai Krupa Das

Clinical Research Faculty Publications

Objectives: The aim was to determine the nutritional adequacy of calorie restricted (CR) diets during CR interventions up to 12 months. Methods: The Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE™) phase 1 trial consisted of 3 single-site studies to test the feasibility and effectiveness of CR in adults without obesity. After baseline assessments, participants who were randomized to a CR intervention received education and training from registered dietitians on how to follow a healthful CR diet. Food diaries were completed at baseline and during the CR interventions (~6, 9, and 12 months) when participants were self-selecting …

Testosterone Undecanoate Administration Prevents Declines In Fat-Free Mass But Not Physical Performance During Simulated Multi-Stressor Military Operations, Alyssa N. Varanoske, Melissa N. Harris, Callie Hebert, Emily E. Howard, Neil M. Johannsen, Steven B. Heymsfield, Frank L. Greenway, Lee M. Margolis, Harris R. Lieberman, Robbie A. Beyl, David D. Church, Arny A. Ferrando, Stefan M. Pasiakos, Jennifer C. Rood

Clinical Research Faculty Publications

Male military personnel conducting strenuous operations experience reduced testosterone concentrations, muscle mass, and physical performance. Pharmacological restoration of normal testosterone concentrations may attenuate performance decrements by mitigating muscle mass loss. Previously, administering testosterone enanthate (200 mg/wk) during 28 days of energy deficit prompted supraphysiological testosterone concentrations and lean mass gain without preventing isokinetic/isometric deterioration. Whether administering a practical dose of testosterone protects muscle and performance during strenuous operations is undetermined. The objective of this study was to test the effects of a single dose of testosterone undecanoate on body composition and military-relevant physical performance during a simulated operation. After a …

Gradient And Acceleration Of Decline In Physical And Cognitive Functions In Older Adults: A Disparity Analysis, H. Ip Edward, Shyh Huei Chen, W. Jack Rejeski, Karen Bandeen-Roche, Kathleen M. Hayden, Christina E. Hugenschmidt, June Pierce, Michael E. Miller, Jaime L. Speiser, Stephen B. Kritchevsky, Denise K. Houston, Robert L. Newton, Stephen R. Rapp, Dalane W. Kitzman

Population and Public Health Science Faculty Publications

Background: Substantive previous work has shown that both gait speed and global cognition decline as people age. Rates of their decline, as opposed to cross-sectional measurements, could be more informative of future functional status and other clinical outcomes because they more accurately represent deteriorating systems. Additionally, understanding the sex and racial disparity in the speed of deterioration, if any, is also important as ethnic minorities are at an increased risk of mobility disability and dementia. Method: Data from 2 large longitudinal intervention studies were integrated. Rates of decline were derived from individual-level measures of gait speed of 400-m walk and …

Obesity Management In The Primary Prevention Of Hepatocellular Carcinoma, Elizabeth R.M. Zunica, Elizabeth C. Heintz, Christopher L. Axelrod, John P. Kirwan

Division of Basic Science Faculty Publications

Hepatocellular carcinoma (HCC) is the most frequent primary hepatic malignancy and a leading cause of cancer-related death globally. HCC is associated with an indolent clinical presentation, resulting in frequent advanced stage diagnoses where surgical resection or transplant therapies are not an option and medical therapies are largely ineffective at improving survival. As such, there is a critical need to identify and enhance primary prevention strategies to mitigate HCC-related morbidity and mortality. Obesity is an independent risk factor for the onset and progression of HCC. Furthermore, obesity is a leading cause of nonalcoholic steatohepatitis (NASH), the fasting growing etiological factor of …

Valley-Floor Snowfall In Taylor Valley, Antarctica, From 1995 To 2017: Spring, Summer And Autumn, Madeline E. Myers, Peter T. Doran, Krista F. Myers

Faculty Publications

We present an analysis of the 20 year snowfall dataset in Taylor Valley and the results of a new snow cover monitoring study. Snowfall has been measured at four sites in Taylor Valley from 1995 to 2017. We focus on valley-floor snowfall when wind does not exceed 5 m s-1, and we exclude winter from our analysis due to poor data quality. Snowfall averaged 11 mm water equivalent (w.e.) from 1995 to 2017 across all stations and ranged from 1 to 58 mm w.e. Standard deviations ranged from 3 to 17 mm w.e., highlighting the strong interannual variability of snowfall …

Weak Thermal State Quadrature-Noise Shadow Imaging, Pratik J. Barge, Ziqi Niu, Savannah L. Cuozzo, Eugeniy E. Mikhailov, Irina Novikova, Hwang Lee, Lior Cohen

Faculty Publications

In this work, we theoretically and experimentally demonstrate the possibility to create an image of an opaque object using a few-photon thermal optical field. We utilize the quadrature-noise shadow imaging (QSI) technique that detects the changes in the quadrature-noise statistics of the probe beam after its interaction with an object. We show that such a thermal QSI scheme has an advantage over the classical differential imaging when the effect of dark counts is considered. At the same time, the easy availability of thermal sources for any wavelength makes the method practical for broad range of applications, not accessible with, e.g., …

Alteration Of Biomolecular Conformation By Aluminum-Implications For Protein Misfolding Disease, Yuhai Zhao, Aileen I. Pogue, Peter N. Alexandrov, Leslie G. Butler, Wenhong Li, Vivian R. Jaber, Walter J. Lukiw

Faculty Publications

The natural element aluminum possesses a number of unique biochemical and biophysical properties that make this highly neurotoxic species deleterious towards the structural integrity, conformation, reactivity and stability of several important biomolecules. These include aluminum’s (i) small ionic size and highly electrophilic nature, having the highest charge density of any metallic cation with a Z²/r of 18 (ionic charge +3, radius 0.5 nm); (ii) inclination to form extremely stable electrostatic bonds with a tendency towards covalency; (iii) ability to interact irreversibly and/or significantly slow down the exchange-rates of complex aluminum–biomolecular interactions; (iv) extremely dense electropositive charge with one …