Digital Commons Network^™

Kinetics, Products, And Brown Carbon Formation By Aqueous-Phase Reactions Of Glycolaldehyde With Atmospheric Amines And Ammonium Sulfate, David O. De Haan, Alyssa A. Rodriguez, Michael A. Rafla, Hannah G. Welsh, Elyse A. Pennington, Jason R. Casar, Lelia N. Hawkins, Natalie G. Jimenez, Alexia De Loera, Devoun R. Stewart, Antonio Rojas, Matthew-Khoa Tran, Peng Lin, Alexander Laskin, Paola Formenti, Mathieu Cazaunau, Edouard Pangui, Jean-François Doussin

Chemistry and Biochemistry: Faculty Scholarship

Glycolaldehyde (GAld) is a C₂ water-soluble aldehyde produced during the atmospheric oxidation of isoprene and many other species and is commonly found in cloudwater. Previous work has established that glycolaldehyde evaporates more readily from drying aerosol droplets containing ammonium sulfate (AS) than does glyoxal, methylglyoxal, or hydroxyacetone, which implies that it does not oligomerize as quickly as these other species. Here, we report NMR measurements of glycolaldehyde’s aqueous-phase reactions with AS, methylamine, and glycine. Reaction rate constants are smaller than those of respective glyoxal and methylglyoxal reactions in the pH range of 3–6. In follow-up cloud chamber experiments, deliquesced …

Enhancing Interprofessional Collaboration And Interprofessional Education In Women's Health, Laura Baecher-Lind, Angela C Fleming, Rashmi Bhargava, Susan M Cox, Elise N Everett, David A Forstein, Shireen Madani Sims, Helen K Morgan, Christopher M Morosky, Celeste S Royce, Tammy S Sonn, Jill M Sutton, Scott C Graziano

2020-Current year OA Pubs

This article is from the 'To The Point' series from the Association of Professors of Gynecology and Obstetrics Undergraduate Medical Education Committee. The purpose of this review is to provide an understanding of the differing yet complementary nature of interprofessional collaboration and interprofessional education as well as their importance to the specialty of Obstetrics and Gynecology. We provide a historical perspective of how interprofessional collaboration and interprofessional education have become key aspects of clinical and educational programs, enhancing both patient care and learner development. Opportunities to incorporate interprofessional education within women's health educational programs across organizations are suggested. This is …

Maturation And Substrate Processing Topography Of The Plasmodium Falciparum Invasion/Egress Protease Plasmepsin X, Sumit Mukherjee, Suong Nguyen, Eashan Sharma, Daniel E Goldberg

2020-Current year OA Pubs

The malaria parasite Plasmodium invades a host erythrocyte, multiplies within a parasitophorous vacuole (PV) and then ruptures the PV and erythrocyte membranes in a process known as egress. Both egress and invasion are controlled by effector proteins discharged from specialized secretory organelles. The aspartic protease plasmepsin X (PM X) regulates activity for many of these effectors, but it is unclear how PM X accesses its diverse substrates that reside in different organelles. PM X also autoprocesses to generate different isoforms. The function of this processing is not understood. We have mapped the self-cleavage sites and have constructed parasites with cleavage …

Hepatic Transcript Signatures Predict Atherosclerotic Lesion Burden Prior To A 2-Year High Cholesterol, High Fat Diet Challenge, Sobha Puppala, Kimberly D. Spradling-Reeves, Jeannie Chan, Shifra Birnbaum, Deborah E. Newman, Anthony G. Comuzzie, Michael Mahaney, John L. Vandeberg, Michael Olivier, Laura Cox

School of Medicine Publications

The purpose of this study was to identify molecular mechanisms by which the liver influences total lesion burden in a nonhuman primate model (NHP) of cardiovascular disease with acute and chronic feeding of a high cholesterol, high fat (HCHF) diet. Baboons (47 females, 64 males) were fed a HCHF diet for 2 years (y); liver biopsies were collected at baseline, 7 weeks (w) and 2y, and lesions were quantified in aortic arch, descending aorta, and common iliac at 2y. Unbiased weighted gene co-expression network analysis (WGCNA) revealed several modules of hepatic genes correlated with lesions at different time points of …

Rare Genetic Variants Explain Missing Heritability In Smoking, Seon-Kyeong Jang, Luke Evans, Allison Fialkowski, Donna K. Arnett, Allison E. Ashley-Koch, Kathleen C. Barnes, Diane M. Becker, Joshua C. Bis, John Blangero, Eugene R. Bleecker

School of Medicine Publications

Common genetic variants explain less variation in complex phenotypes than inferred from family-based studies, and there is a debate on the source of this ‘missing heritability’. We investigated the contribution of rare genetic variants to tobacco use with whole-genome sequences from up to 26,257 unrelated individuals of European ancestries and 11,743 individuals of African ancestries. Across four smoking traits, single-nucleotide-polymorphism-based heritability (h2SNP) was estimated from 0.13 to 0.28 (s.e., 0.10–0.13) in European ancestries, with 35–74% of it attributable to rare variants with minor allele frequencies between 0.01% and 1%. These heritability estimates are 1.5–4 times higher than past estimates based …

Engineering Hyaluronic Acid For The Development Of New Treatment Strategies For Osteoarthritis, Yu Seon Kim, Farshid Guilak

2020-Current year OA Pubs

Osteoarthritis (OA) is a degenerative joint disease that is characterized by inflammation of the joints, degradation of cartilage, and the remodeling of other joint tissues. Due to the absence of disease-modifying drugs for OA, current clinical treatment options are often only effective at slowing down disease progression and focus mainly on pain management. The field of tissue engineering has therefore been focusing on developing strategies that could be used not only to alleviate symptoms of OA but also to regenerate the damaged tissue. Hyaluronic acid (HA), an integral component of both the synovial fluid and articular cartilage, has gained widespread …

Left Sided Breast Cancer Is Associated With Aggressive Biology And Worse Outcomes Than Right Sided Breast Cancer, Yara Abdou, Medhavi Gupta, Mariko Asaoka, Kristopher Attwood, Opyrchal Mateusz, Shipra Gandhi, Kazuaki Takabe

2020-Current year OA Pubs

Breast cancer is more common on the left side than the right side. We aim to evaluate differences in clinicopathological and genomic characteristics based on laterality. We analyzed survival outcomes and clinical characteristics of 881,320 patients recorded by the Surveillance, Epidemiology, and End Results (SEER) program. The Cancer Genome Atlas (TCGA) was used to explore genomic and clinical features from 1,062 patients. Gene expression data was used to quantitate cytolytic activity and hallmark gene-sets were used for gene set enrichment analysis. An institutional retrospective review was conducted on 155 patients treated with neoadjuvant chemotherapy (NACT). Patient characteristics were summarized by …

Glycan Shield Of The Ebolavirus Envelope Glycoprotein Gp, Weiwei Peng, Vamseedhar Rayaprolu, Amar D Parvate, Matti F Pronker, Sean Hui, Diptiben Parekh, Kelly Shaffer, Xiaoying Yu, Erica O Saphire, Joost Snijder

2020-Current year OA Pubs

The envelope glycoprotein GP of the ebolaviruses is essential for host cell entry and the primary target of the host antibody response. GP is heavily glycosylated with up to 17 N-linked sites, numerous O-linked glycans in its disordered mucin-like domain (MLD), and three predicted C-linked mannosylation sites. Glycosylation is important for host cell attachment, GP stability and fusion activity, and shielding from neutralization by serum antibodies. Here, we use glycoproteomics to profile the site-specific glycosylation patterns of ebolavirus GP. We detect up to 16 unique O-linked glycosylation sites in the MLD, and two O-linked sites in the receptor-binding GP1 subunit. …

Exoskeletal Predator Defenses Of Juvenile California Spiny Lobsters (Panulirus Interruptus) Are Affected By Fluctuating Ocean Acidification-Like Conditions, Kaitlyn B. Lowder, Maya S. Devries, Ruan Hattingh, James M.D. Day, Andreas J. Andersson, Phillip J. Zerofski, Jennifer R.A. Taylor

Faculty Research, Scholarly, and Creative Activity

Spiny lobsters rely on multiple biomineralized exoskeletal predator defenses that may be sensitive to ocean acidification (OA). Compromised mechanical integrity of these defensive structures may tilt predator-prey outcomes, leading to increased mortality in the lobsters’ environment. Here, we tested the effects of OA-like conditions on the mechanical integrity of selected exoskeletal defenses of juvenile California spiny lobster, Panulirus interruptus. Young spiny lobsters reside in kelp forests with dynamic carbonate chemistry due to local metabolism and photosynthesis as well as seasonal upwelling, yielding daily and seasonal fluctuations in pH. Lobsters were exposed to a series of stable and diurnally fluctuating reduced …

C3ar Plays Both Sides In Regulating Resistance To Bacterial Infections, Jesse A. Corcoran, Brooke A. Napier

Biology Faculty Publications and Presentations

Activation of the complement pathway results in the production of bioactive C3a, a product of C3 cleavage, which interacts with membrane-bound receptor C3aR to regulate innate immune cell function and outcome of bacterial infection. Specifically, previous research has identified mechanistically distinct and cell type–specific roles for C3aR in regulating innate immune cell inflammatory state, antimicrobial killing capacity, and metabolism. Historically, the production of C3a has been relegated to the serum; however, recent studies have provided evidence that various cell types can produce intracellular C3a that stimulates intracellular C3aR. In light of these new results, it is imperative that we revisit …

On Epidemiology As Racial-Capitalist (Re)Colonization And Epistemic Violence, Ryan J. Petteway

OHSU-PSU School of Public Health Faculty Publications and Presentations

This commentary reflects upon power-knowledge dynamics and matters of epistemic, procedural, and distributive justice that undergird epidemiological knowledge production related to racial health inequities in the U.S. Grounded in Foucault’s power-knowledge concepts—“objects”, “ritual”, and “the privileged”—and guided by Black feminist philosopher Kristie Dotson’s conceptualization of epistemic violence, it critiques the dominant positivist, reductionist, and extractivist paradigm of epidemiology, interrogating the settler-colonial and racial-capitalist nature of the knowledge production/curation enterprise. The commentary challenges epidemiology’s affinity for epistemological, procedural, and methodological norms that effectively silence/erase community knowledge(s) and nuance in favor of reductionist empirical representations/re-presentations produced by researchers who, often, have never …

Development Of The Centrifugal Blood Pump For A Hybrid Continuous Flow Pediatric Total Artificial Heart: Model, Make, Measure, Carson S Fox, Thomas Palazzolo, Matthew Hirschhorn, Randy M Stevens, Joseph Rossano, Steven W Day, Vakhtang Tchantchaleishvili, Amy L Throckmorton

Department of Medicine Faculty Papers

Clinically-available blood pumps and total artificial hearts for pediatric patients continue to lag well behind those developed for adults. We are developing a hybrid, continuous-flow, magnetically levitated, pediatric total artificial heart (TAH). The hybrid TAH design integrates both an axial and centrifugal blood pump within a single, compact housing. The centrifugal pump rotates around the separate axial pump domain, and both impellers rotate around a common central axis. Here, we concentrate our development effort on the centrifugal blood pump by performing computational fluid dynamics (CFD) analysis of the blood flow through the pump. We also conducted transient CFD analyses (quasi-steady …

Batterer Intervention Program Evaluation: A Portland, Oregon Program Case Study, Julie M. Conner

University Honors Theses

Batterer intervention programming (BIP) has shown up as a source of treatment for men who abuse women since the late nineteen-seventies and have since continued to expand. Research has been done to examine how effective these programs are in many different settings at reducing intimate partner violence, but little is known about programs specific to the state of Oregon. BIPs are used as an alternative to incarceration for individuals convicted of domestic violence: existing programs are based on the Duluth Model and Cognitive Behavioral Theory (CBT). Other modalities have utilized trauma-informed approaches, psychoeducation, holistic modeling, and risks, need, and responsivity …

Understanding Patient And Caregiver Perspectives Using A Dyad Approach For Data Collection: A Systematic Review Of The Literature, Jane Loftus, Andrew Yaworsky, Diane M. Turner-Bowker, Andrew Palladino, Roger Lamoureux, Emily Love, Andreas M. Pleil

Patient Experience Journal

Treatments outside of a clinical setting may be managed independently by the pediatric patient, independently by a caregiver, or by the patient and caregiver together. Best practices for pediatric clinical outcome assessment (COA) recommend patient-reported outcome (PRO) and/or observer-reported outcome (ObsRO) measures to assess the patient experience of a condition or its treatment. However, a dyad approach where patients and caregivers can complete assessments together may be useful for assessing a shared treatment experience that may not be adequately captured by a PRO and/or an ObsRO. A systematic, targeted literature review of empirical literature was conducted to identify and describe …

Identifying Biomarkers To Select Patients With Borderline Resectable And Locally Advanced Pancreatic Ductal Adenocarcinoma (Brpc, Lapc) For Radiotherapy (Rt), Grace L. Waterman, Galia Jacobson, Connor Thunshelle, Eugene J. Koay Md, Phd

Summer Experience 2022

No abstract provided.

The Role Of Exosomal Mir-181c-3p Within The Ovarian Tumor Microenvironment, Anam Rawoof, Chi Lam Au Yeung, Rita Siu Fee Cheng, Sammy Ferri-Borgogno, Samuel C. Mok

Summer Experience 2022

No abstract provided.

Role Of Wilms' Tumor 1 In Sex Development, Jasmine L. Terrell, Jace A. Aloway, Cristy Ruteshouser, Vicki Huff Phd, Richard R. Behringer

Summer Experience 2022

No abstract provided.

Role Of Ash1l In Prostate Cancer Metastasis, Anna Debruine, Chenling Meng, Di Zhao

Summer Experience 2022

No abstract provided.

Surveillance Of Response To Parp Inhibitors Using Characterized Extracellular Vesicles, Laura Xuan Nguyen, Sara Corvigno

Summer Experience 2022

No abstract provided.

Probing Spatial Myeloid Heterogeneity In Glioblastoma, Derek L. Chien, Mohammad F. Zaman, Fatma Betul Aksoy Yasar, Daniel B. Zamler, Ailiang Zeng, Jian Hu

Summer Experience 2022

No abstract provided.

Ccr7 Immune Cell Receptor Expression In Inflammatory Breast Cancer, Alison N. Lawrence, Wendy A. Woodward, Savitri Krishnamurthy, Wintana Balema, Richard Larson, Megan M. Rodriguez, Natalie Fowlkes, Naoto T. Ueno

Summer Experience 2022

No abstract provided.

Glycosylated Collagen Interaction With Cells Through Ddrs And Integrin, Emma R. Burris, Shike Wang, Hou-Fu Guo, Jonathan M. Kurie

Summer Experience 2022

No abstract provided.

Evaluating The Reproducibility Of Gene Regulatory Networks Construction Using Biological Replicates, Taylor Carpenter, Daniel Osorio Phd, Stephen Yi, Nidhi Sahni Phd

Summer Experience 2022

No abstract provided.

Evaluation Of Newly Generated Lrp1 Antibodies In Different Cell Types: Thp1 Cancer Cell Line, Human And Mouse Immune Cells, Scott Daniel Semelsberger, Olga Sizova, Dan Li, Qing Ma, Lisa St. John, Gheath Al Atrash, Jeffrey Molldrem

Summer Experience 2022

No abstract provided.

Comparative Analysis Of The Associate Board Of The Royal Schools Of Music Of The United Kingdom And The African Music Curriculum Of Kenya, David O. Akombo, Barbra A. Akombo

Visions of Research in Music Education

The music curricula and the pedagogical methods used in the United Kingdom and in Kenya share trends that are both common and diverse. In this article we present our comparisons of the Associate Board of the Royal Schools of Music (ABRSM) and the Kenyan music curriculum. We approach this comparative study using Ralph Tyler’s definition of curriculum as a theoretical framework. The paper evaluates how the two curricular are shaped by Tyler’s sociocentric model by addressing the following four question:(1) What are the roles of a music education curriculum in the United Kingdom and in Kenya?; (2) What factors influence …

Chronic Obstructive Pulmonary Disease (Copd), Joseph Earich

Nursing Student Class Projects (Formerly MSN)

Background: Chronic Obstructive Pulmonary Disease (COPD) is an irreversible, preventable respiratory disease characterized by airflow limitation and obstruction that is usually progressive. COPD affects millions of people globally and over $7 billion dollars is spent on COPD related hospitalizations in the U.S. annually. This poster includes information focused on COPD, the underlying pathophysiology, clinical manifestations, diagnosis, nursing care implications, and treatment.

Methods: Research articles within the last five years were obtained using keywords such as COPD, pathophysiology, treatment, prevention, emphysema, and chronic bronchitis from databases EBSCO and PubMed. The data and quality of these articles were assessed and information compiled …

Brenno Blauth’S Compositional Style Elements: A Study On The Sonata For Flute And Piano, T.5., Thiago Bohm Bottega

Dissertations

The Sonata para Flauta e Piano, T.5, by Brenno Blauth (1931-1993), is a standard of the Brazilian flute repertoire. This document studies its folk and Brazilian popular music elements in order to better understand Blauth’s compositional rationale.

In 1959 Blauth was responsible for the creation of the group Movimento Musical Renovador. Based in Rio de Janeiro, MMR gathered renowned composers and performers with the goal of promoting Brazilian classical music. Chapter III is dedicated to the group’s initiatives, taking its political and cultural contextualization into account.

Chapter IV is dedicated to the study of Blauth’s compositional style shifts …

Genomics-Informed Nursing Care: A Survey Of Nicu Nurses' Experience And Perspectives Related To Genomic Sequencing, Rachel I. Anderson

Theses and Dissertations

Background: Genomic sequencing is used in the Neonatal Intensive Care Unit (NICU) to diagnose babies with genetic disorders. Purpose: To explore the experiences and knowledge of nurses working in NICUs related to genomic sequencing. Methods: This was a mixed-methods, cross-sectional descriptive survey of NICU nurses attending a national conference. Quantitative data were analyzed using descriptive statistics. Qualitative data were coded into categories and themes. Results: Of 188 NICU nurses, nearly half reported experience with genomic sequencing. Among nurses with experience, 62.7% rated the amount of discussion they had with families about genomic sequencing as "0". Additionally, 72.7% of participants reported …

Uab Medicine Opens Surgery Clinic At Northwest Regional Health, Alicia Rohan

Browse All News

No abstract provided.

Design And Performance Of A Directional Permeability Membrane, Hamidreza Bayat

Mechanical Engineering Research Theses and Dissertations

A directional permeability membrane was designed, fabricated, and tested with the goal of allowing flow in one direction and preventing flow in the opposite direction. The membranes were constructed from two porous polyimide sheets with different thicknesses and bonded with double sided tape on the perimeter to create a separation in the range of 25-75 µm. Nine holes with diameter of 0.5 and 1 mm were cut in a polyimide sheet with thickness of 125 µm and four circular holes with diameter of 0.25 mm were cut in a polyimide sheet with thickness of 25 µm. The holes were cut …