Digital Commons Network^™

The Effects Of Digital Game-Based Instruction On Knowledge Acquisition And Retention Of Genetics Content, Brinley Kantorski

Electronic Theses and Dissertations

Digital educational games have been a part of the educational landscape since the early 1970s. Since then, there has been a proliferation in the quantity, format, type, and quality of digital educational games available to classroom teachers. Despite this, the body of literature surrounding the effectiveness of these digital educational games remains highly fragmented and lacks unifying themes. While some literature exists to support the use of digital educational games in immediate knowledge acquisition, little research has been done on how digital educational games impact the retention of knowledge in the long term. As such, this study examines how the …

Identification And Characterization Of Genetic Elements That Regulate A C-Di-Gmp Mediated Multicellular Trait In Pseudomonas Fluorescens, Collin Kessler

Electronic Theses and Dissertations

Microbial communities contain densely packed cells where competition for space and resources are fierce. These communities are generally referred to as biofilms and provide advantages to individual cells against immunological and antimicrobial intervention, dehydration, and predation. High intracellular pools of cyclic diguanylate monophosphate (c-di-GMP) cause cells to aggregate during biofilm formation through the production of diverse extracellular polymers. Genes that encode c-di-GMP catalytic enzymes are commonly mutated during chronic infections where opportunists display enhanced resistance to phagocytosis and antibiotics. Our lab uses an emergent multicellular trait in the model organism Pseudomonas fluorescens Pf0-1 to study the emergence of c-di-GMP mutations …

'Bleeding-In-The-World': A Qualitative Study Of Self-Cutting And Blood, Sadie Mohler

Electronic Theses and Dissertations

This dissertation is an existential, phenomenological study of the role and meaning of blood in self-cutting. Using in-depth, open-ended interviews with participants who self-cut, the author gathered data on the multisensorial experience of blood and bleeding in self-cutting. Data analysis was organized around the lifeworld existentials of corporeality, temporality, spatiality, communication, and relationality. The impact of blood and bleeding across each lifeworld dimension emphasized highly relevant, and previously unstudied, aspects of the lived experience of self-cutting. The six themes identified and explored are (a) blood as an animate abject; (b) bleeding and control; (c) bleeding is a process and the …

Effects Of Meteorological And Land Surface Modeling Uncertainty On Errors In Winegrape Et Calculated With Sims, Conor T. Doherty, Lee F. Johnson, John Volk, Meagan S. Mauter, Nicolas Bambach, Andrew J. Mcelrone, Joseph G. Alfieri, Lawrence E. Hipps, John H. Prueger, Sebastian J. Castro, Maria Mar Alsina, William P. Kustas, Forrest S. Melton

AES Faculty Publications and Presentations

Characterization of model errors is important when applying satellite-driven evapotranspiration (ET) models to water resource management problems. This study examines how uncertainty in meteorological forcing data and land surface modeling propagate through to errors in final ET data calculated using the Satellite Irrigation Management Support (SIMS) model, a computationally efficient ET model driven with satellite surface reflectance values. The model is applied to three instrumented winegrape vineyards over the 2017-2020 time period and the spatial and temporal variation in errors are analyzed. We illustrate how meteorological data inputs can introduce biases that vary in space and at seasonal timescales, but …

Immunotherapy For Type 1 Diabetes Mellitus By Adjuvant-Free Schistosoma Japonicum-Egg Tip-Loaded Asymmetric Microneedle Patch (Stamp), Haoming Huang, Dian Hu, Zhuo Chen, Jiarong Xu, Rengui Xu, Yusheng Gong, Zhengming Fang, Ting Wang, Wei Chen

Faculty, Staff and Student Publications

BACKGROUND: Type 1 diabetes mellitus (T1DM) is an autoimmune disease mediated by autoreactive T cells and dominated by Th1 response polarization. Insulin replacement therapy faces great challenges to this autoimmune disease, requiring highly frequent daily administration. Intriguingly, the progression of T1DM has proven to be prevented or attenuated by helminth infection or worm antigens for a relatively long term. However, the inevitable problems of low safety and poor compliance arise from infection with live worms or direct injection of antigens. Microneedles would be a promising candidate for local delivery of intact antigens, thus providing an opportunity for the clinical immunotherapy …

Planttracker: An R Package To Translate Maps Of Plant Occurrence Into Demographic Data, Alice E. Stears, Peter B. Adler, Shannon E. Albeke, David H. Atkins, Jared Studyvin, Daniel C. Laughlin

Wildland Resources Faculty Publications

1. Long-term demographic data are rare yet invaluable for conservation, management, and basic research on the underlying mechanisms of population and community dynamics. Historical and contemporary mapped datasets of plant location and basal area present a relatively untapped source of demographic records that, in some cases, span over 20 years of sequential data collection. However, these maps do not uniquely mark individual plants, making the process of collecting growth, survival, and recruitment data difficult.
2. Recent efforts to translate historical maps of plant occurrence into shapefiles make it possible to use computer algorithms to track individuals through time and determine individual growth …

Circadian Rhythms Mediate Infection Risk In Daphnia Dentifera, Alaina C. Pfenning-Butterworth, David T. Nguyen, Jessica L. Hite, Clayton E. Cressler

School of Biological Sciences: Faculty Publications

Biological rhythms mediate important within-host processes such as metabolism, immunity, and behavior which are often linked to combating disease exposure. For many hosts, exposure to pathogens occurs while feeding. However, the link between feeding rhythms and infection risk is unclear because feeding behavior is tightly coupled with immune and metabolic processes which may decrease susceptibility to infection. Here, we use the Daphnia dentifera–Metschnikowia bicuspidata host–pathogen system to determine how rhythms in feeding rate and immune function mediate infection risk. The host is known to have a nocturnal circadian rhythm in feeding rate, yet we found that they do not exhibit …

Keeping 21st Century Paleontology Grounded: Quantitative Genetic Analyses And Ancestral State Reconstruction Re-Emphasize The Essentiality Of Fossils, Tesla A. Monson, Marianne F. Brasil, Michael Mahaney, Christopher A. Schmitt, Catherine E. Taylor, Leslea J. Hlusko

School of Medicine Publications

Advances in genetics and developmental biology are revealing the relationship between genotype and dental phenotype (G:P), providing new approaches for how paleontologists assess dental variation in the fossil record. Our aim was to understand how the method of trait definition influences the ability to reconstruct phylogenetic relationships and evolutionary history in the Cercopithecidae, the Linnaean Family of monkeys currently living in Africa and Asia. We compared the two-dimensional assessment of molar size (calculated as the mesiodistal length of the crown multiplied by the buccolingual breadth) to a trait that reflects developmental influences on molar development (the inhibitory cascade, IC) and …

Calm-Mo: An Integrative Tool For Psychological Mindfulness, Charles L. Miller

Dissertations, 2020-current

Henriques has developed a “Unified Theory” that consists of eight key ideas he argues can effectively frame both the science of psychology and the practice of psychotherapy. CALM-MO, the eighth of these ideas, offers an integrative, principled approach to psychological mindfulness. CALM-MO is an acronym that encapsulates the process of cultivating a “calm” meta-cognitive observer that embodies the attitudes of curiosity, acceptance, loving compassion, and motivation toward valued states of being. Henriques posits that the idea consolidates key elements from across the various schools of thought to bring together essential therapeutic principles geared toward seeking and maintaining well-being. As such, …

Neural Stem Cells: Age-Dependent Outcomes During Viral Infections In The Central Nervous System, Manisha N. Chandwani

Electronic Theses and Dissertations

Viral infections in the central nervous system (CNS) are associated with neurodevelopmental and neurobehavioral deficits. The outcomes of viral infections can be driven by damage and death of neurons. Neural stem cells (NSCs) play key roles in neurodevelopment, repair, and physiological brain function. During a viral infection, NSC activity can disturbed by direct infection of NSCs by the virus or by anti-viral immune response. Here, we aimed to assess whether the anti-viral immune response can impact NSC activity during an immunocompetent response in the adult brain. We utilized a transgenic mouse model of Measles virus infection where only the CNS …

Using Heritage Sites At Bahariya Oasis On The Tourism Urban Development, Medhat Ahmed Shabaan Samra

Mansoura Engineering Journal

Throughout the tourism planning process for the Bahariya Oasis area, the current study aims to prepare this area to become an applicable model that converts the values of cultural heritage resources into economic values within the tourism industry and the establishment of tourism projects in this area. The Bahariya Oasis area is characterized by many Valuable regions that have not been included on the tourism map by the Egyptian government. To achieve those objectives, the researcher adopted the 'Analytic-Descriptive Approach', as it is suitable for this study throughout reviewing the literature related to the research subject, describing the current situation, …

Attitudes Toward Transgenic Corn Usage Among Amish & Conservative Mennonite Farmers In Ohio, Scot Long

Journal of Amish and Plain Anabaptist Studies

Mass adoption and planting of genetically modified corn are part of the larger industrialized agricultural production system in the United States. Amish and conservative Mennonite farmers in the Holmes County settlement region offer an alternative production system often characterized by lower usage of chemical inputs, greater implementation of crop rotation, and significantly higher usage of hybrid versus GMO field corn. Moreover, the rationale among Amish/Mennonite farmers toward adoption of GMO (based on “convenience”) or rejection of GMO (based on “too many unknowns”) stems both from cultural diffusion of neighboring farms as well as variable need for nonfarm income. This article …

Manual Of Sustainable Urban Practices Towards Long-Term Conservation, Haley Kilmer

Capstone Collection

This paper analyzes how urban living and design can be detrimental to the surrounding ecosystems and how it is directly affecting the biodiversity loss of an area. To answer this question, I first did extensive background research on urbanization, climate change, and biodiversity loss as it relates to urban ecosystems. Then, the public’s perceptions were collected through surveys and interviews in order to make meaningful suggestions in the construction of an interactive, biological corridor map. The results showed that increasing the biodiversity of an urban area can help to mitigate many of the common environmental challenges associated with living in …

Sustainable Avitourism On Curieuse Island In The Seychelles, Chesley Davis

Capstone Collection

In Seychelles, tourism is a vital part of the country’s overall economy. Increasingly, sustainable tourism is essential to conserve environments and wildlife, meet the needs of local communities and the state, and ensure the longevity of high-quality experiences for international visitors to the country. This project assesses sustainability of avitourism on Curieuse Island. The Seychelles has many endemic and pelagic birds that draw tourists from around the world, including the Seychelles Black Parrot, Seychelles Magpie Robin, and Seychelles Flycatcher. This is a mixed methods research project that entails bird biodiversity surveys, examination of birding databases, and personal observations. This study …

Infographic: How Well Are Australian Schools Teaching Students About Menstrual Health?, Zoe Kaskamanidis

Teacher infographics

Findings from a cross-sectional survey looking into young Australian women’s experiences of menstruation and dysmenorrhea indicate the need for better menstrual health education in Australian schools. Find out more about the survey responses in relation to menstrual health in Australian Health and Physical Education in today’s infographic.

Medical School Watercooler Newsletter - August 12, 2022, Lindsey Lyle

Watercooler Newsletter

This is the August 12, 2022 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents include:

• USA receives $2.6 million grant to study infection dynamics of an emerging tick-borne virus
• Summer research award winners announced
• Researchers identify novel independent regulator of colon cancer angiogenesis
• Meet a Med Student: Justin Penninger
• Precision Medicine Traveling Exhibit coming to USA Biomedical Library

No Association Between Perinatal Mood Disorders And Hypertensive Pregnancies, Sarah Araji, Ashley Griffin, Wondwosen Kassahun-Yimer, Laura Dixon, Shauna Kay Spencer, Sheila Belk, Gail Ohaegbulam, Kedra Wallace

Faculty and Student Publications

Mental health disorders such as anxiety and/or depression are the most common mental health disorders seen among reproductive aged women and can increase during pregnancy. Many sociodemographic risk factors have been associated with anxiety and/or depression in pregnancy, which can lead to adverse maternal and infant outcomes including the risk of a hypertensive pregnancy. The current study prospectively examined self-reported anxiety, depression and stress in pregnant women without a history of fetal loss or mood disorders beginning at 20–26 weeks. At each study visit, circulating immune factors associated with perinatal mood disorders were measured in blood samples that were collected. …

Educating Providers Without Prescriptive Authority About Psychopharmacology Basics: Bridging The Interdisciplinary Work Among Psychotropic Prescribers And Psychologists, Olivia Ceja

Doctor of Nursing Practice (DNP) Projects

Background: The purpose of this evidence-based change in practice is to increase the fund of knowledge among psychologists, licensed clinical social workers, and talk therapists in outpatient psychiatric settings by educating clinicians about psychopharmacologic basics and the role and work of a psychiatric nurse practitioner during group supervision meetings. This can help bridge the gap of psychopharmacologic knowledge between mental health providers with and without prescriptive authority.

Problem: Evidence shows that psychologists with non-prescribing capabilities are not often trained or educated about the very medications that their clients are often taking. Currently, psychotropic medication education is not a standard aspect …

Maple '22 Examines Injury Prevention Technique For Athletes, Julia Perez

News and Events (Discontinued Series)

No abstract provided.

The Role Of Teacher Efficacy In Readiness To Support Lgbtq+ Students In Schools, Andrew Levy

Educational Specialist, 2020-current

LGBTQ+ students experience a myriad of difficulties associated specifically with their sexual or gender minority status. The current body of research has focused on negative outcomes of these difficulties, while there is a dearth of research into how schools can position stakeholders to support these students. Teachers often serve as consistent, direct points of contact for students in schools. As such, this study aims to explore teacher candidates’ sense of professional self-efficacy and its relationship with their confidence in supporting LGBTQ+ students in three ways: individual interventions, developing their own knowledge and skills, and systems-level advocacy. Teacher candidates were surveyed …

Social Justice Informed School Counseling: A Conceptual Model For Promoting Academic Achievement And Equity Among Dual-Enrolled African American Students, Sylvester Hanner

Electronic Theses and Dissertations

To promote college enrollment, high schools may offer students the opportunity to participate in dual enrollment programs. Students who gain college credit while earning a high school diploma may be more likely to graduate college on time and at a lower cost (College Board, 2017). Despite the benefits of dual enrollment, African American students lack equitable access to dual enrollment programs. Additionally, when they are afforded access to participate in dual enrollment courses, they have a lower academic success rate when compared to White students (CCRC Fink, 2017).

This study provides insight into concepts related to African American students’ opinions, …

Labeling Melanoma Cells With Black Microspheres For Improved Sensitivity In Detection Via Photoacoustic Flow Cytometry, Tori Kocsis

Electronic Theses and Dissertations

Melanoma is an aggressive form of skin cancer known for developing into metastatic disease. Current clinical diagnostics, including medical imaging and tissue biopsy, provide a poor prognosis since the cancer is in the late stages of disease progression. In recent years, photoacoustic flow cytometry has allowed for the detection of circulating melanoma cells within patient blood samples in vitro. Although this method exploits the naturally-produced melanin within the cells, it has only successfully detected highly-pigmented melanoma cell lines. Since various forms of melanoma exist, each with varying melanin concentrations, this research aims to provide a novel method for detecting lightly-pigmented …

The All Of Us Research Program: Data Quality, Utility, And Diversity, Andrea H. Ramirez, Lina Sulieman, David J. Schlueter, Alese Halvorson, Jun Qian, Francis Ratsimbazafy, Roxana Loperena, Kelsey Mayo, Melissa Basford, Nicole Deflaux, Karthik N. Muthuraman, Karthik Natarajan, Abel Kho, Hua Xu, Consuelo Wilkins, Hoda Anton-Culver, Eric Boerwinkle, Mine Cicek, Cheryl R. Clark, Elizabeth Cohn, Lucila Ohno-Machado, Sheri D. Schully, Brian K. Ahmedani, Maria Argos, Robert M. Cronin, Christopher O'Donnell, Mona Fouad, David B. Goldstein, Philip Greenland, Scott J. Hebbring, Elizabeth W. Karlson, Parinda Khatri, Bruce Korf, Jordan W. Smoller, Stephen Sodeke, John Wilbanks, Justin Hentges, Stephen Mockrin, Christopher Lunt, Stephanie A. Devaney, Kelly Gebo, Joshua C. Denny, Robert J. Carroll, David Glazer, Paul A. Harris, George Hripcsak, Anthony Philippakis, Dan M. Roden

Center for Health Policy and Health Services Research Articles

The All of Us Research Program seeks to engage at least one million diverse participants to advance precision medicine and improve human health. We describe here the cloud-based Researcher Workbench that uses a data passport model to democratize access to analytical tools and participant information including survey, physical measurement, and electronic health record (EHR) data. We also present validation study findings for several common complex diseases to demonstrate use of this novel platform in 315,000 participants, 78% of whom are from groups historically underrepresented in biomedical research, including 49% self-reporting non-White races. Replication findings include medication usage pattern differences by …

Board Of Trustees Minutes, August 12, 2022, Coastal Carolina University

Board of Trustees Meeting Minutes

No abstract provided.

The Effect Of Interproximal Home Oral Hygiene On Clinical Parameters In Periodontal Maintenance Patients, Kevin T. Smith

Theses & Dissertations

The purpose of this 6-week, single blinded, randomized clinical trial was to determine if the localized use of an interproximal brush in conjunction with a Bluetooth monitoring device is effective in reducing probing depth (PD), plaque index (PI), and improving clinical attachment level (CAL) in persistent 5-7 mm posterior periodontal pockets in patients receiving periodontal maintenance therapy (PMT) compared to an oral irrigator or interproximal brush alone. Seventy-six patients with a diagnosis of generalized periodontitis Stage III-IV, Grade B periodontitis presenting with a 5-7 mm posterior interproximal PD and a history of bleeding on probing (BOP) were randomly allocated to …

The Effect Of Interproximal Home Regimens Of Inflammatory Biomarkers In Periodontal Maintenance Patients, Grace Moore

Theses & Dissertations

A survey of dental hygienists in general practice (DHGP; n = 74) and periodontal practice (DHPP; n = 62) indicated a difference (p £ 0.04) in preference for interproximal cleaning with oral irrigators (DHGP) and interproximal brushes (DHPP) during periodontal maintenance therapy (PMT). The purpose of the subsequent blinded, randomized controlled clinical trial was to compare the effect of interproximal cleaning aids on reducing inflammation in posterior pockets during PMT. Seventy-six patients on PMT with a 5-7 mm interproximal probing depth were randomly allocated to one of three groups: 1) interproximal brush with tracking device (IB + TD; n=23), 2) …

Investigating The Role Of Splenic Macrophages In Pancreatic Cancer, Daisy V. Gonzalez

Theses & Dissertations

Pancreatic cancer is currently the 3rd leading cause of all cancer-related deaths, with a 5-year survival rate remaining at 10%. The current standard treatment of care and a lack of effective diagnostic markers leaves patients with a dismal prognosis at advanced stages of the disease. This thesis research evaluated the effect of ApoE-expressing macrophages in the spleen. First, we aimed to assess the ApoE expression in the spleen of pancreatic tumor-bearing mice. Results showed that ApoE expression in splenic macrophages increased as the disease progressed. In addition, we saw a significant increase in marginal zone metallophilic macrophages and red pulp …

Post-Transcriptional Control Of The Epithelial-To-Mesenchymal Transition (Emt) In Ras-Driven Colorectal Cancers, Chaitra Rao

Theses & Dissertations

Colorectal cancer (CRC) originates from epithelial cells lining the colon or rectum of the gastrointestinal tract. Most cancer deaths result from a tumor spreading to distant organs; however epithelial cells do not normally migrate from their tissue of origin. To do so, epithelial cells undergo biochemical changes allowing them to acquire behavior similar to motile mesenchymal cells termed the epithelial-to-mesenchymal transition (EMT), which contributes to tumor invasion and metastasis. Our study demonstrated that CRC cells require a molecular scaffold, Kinase Suppressor of Ras 1 (KSR1), and ERK to promote the EMT-like phenotype through the preferential translation of Epithelial Stromal Interaction …

Roles Of C-Terminal Domain Of Dna Polymerase Ζ Catalytic Subunit, Rev3, In Translesion Dna Synthesis And Origin Of Mutations In Yeast, Jian Cui

Theses & Dissertations

Translesion DNA synthesis (TLS) effectively bypasses DNA lesions induced by environmental and endogenous mutagens, protecting cells from replication fork arrest, double-strand breaks, and ultimately cell death. Polymerase ζ (Pol ζ), regulated by ubiquitylation of accessory protein PCNA, plays a key role in TLS. Pol ζ acts as the extender from distorted DNA template/primer termini after damage bypass accomplished by other TLS polymerases exploiting a scaffold of cytidyl transferase Rev1. Pol ζ also makes errors during the synthesis of the downstream region. Both transactions lead to mutations. More than 90% of induced and half of spontaneous mutations in yeast are dependent …

Environmental Exposures And Human Health Challenges: Evidence-Based Insights From Health Surveillance Systems, Jagadeesh Puvvula

Theses & Dissertations

Human exposure to environmental hazards is associated with a variety of preventable adverse health outcomes. As the environmental health risks result from the complex interaction between hazard, exposure, and susceptibility, these exposure-outcome associations are heterogeneous across the population. Improving environmental health literacy by advocating evidence-based environmental risk communication could play a role in reinforcing protective behavior against environmental hazards. The use of public health surveillance systems to assess the exposure-response associations is one of the effective ways to quantify the environmental health risks. However, there are several gaps in effectively quantifying environmental health risks. This dissertation aims to address a …