Capg Is Required For Ebola Virus Infection By Controlling Virus Egress From Infected Cells, Hiroyuki Mori, James P Connell, Callie J Donahue, Ruthmabel Boytz, Yen Thi Kim Nguyen, Daisy W Leung, Douglas J Lacount, Robert A Davey

2020-Current year OA Pubs

The replication of Ebola virus (EBOV) is dependent upon actin functionality, especially at cell entry through macropinocytosis and at release of virus from cells. Previously, major actin-regulatory factors involved in actin nucleation, such as Rac1 and Arp2/3, were shown important in both steps. However, downstream of nucleation, many other cell factors are needed to control actin dynamics. How these regulate EBOV infection remains largely unclear. Here, we identified the actin-regulating protein, CAPG, as important for EBOV replication. Notably, knockdown of CAPG specifically inhibited viral infectivity and yield of infectious particles. Cell-based mechanistic analysis revealed a requirement of CAPG for virus …

Reflections On Beauty, Miklos Nikolaus Legrady

Contemporary Aesthetics (Journal Archive)

No abstract provided.

Assessing Age-Specific Vaccination Strategies And Post-Vaccination Reopening Policies For Covid-19 Control Using Seir Modeling Approach, Xia Wang, Hulin Wu, Sanyi Tang

Faculty, Staff and Student Publications

As the availability of COVID-19 vaccines, it is badly needed to develop vaccination guidelines to prioritize the vaccination delivery in order to effectively stop COVID-19 epidemic and minimize the loss. We evaluated the effect of age-specific vaccination strategies on the number of infections and deaths using an SEIR model, considering the age structure and social contact patterns for different age groups for each of different countries. In general, the vaccination priority should be given to those younger people who are active in social contacts to minimize the number of infections, while the vaccination priority should be given to the elderly …

Inpatient Physical Activity Across A Large University City Hospital: A Behavioral Mapping Study, Karin Valkenet, Prue Mcrae, Elja Reijneveld, Marielle Jans, Petra Bor, Lotte Van Delft, Daniel L. Young, Cindy Veenhof

Physical Therapy Faculty Research

Background: Physical inactivity is common during hospitalization. Physical activity has been described in different inpatient populations but never across a hospital. Purpose: To describe inpatient movement behavior and associated factors throughout a single university hospital. Methods: A prospective observational study was performed. Patients admitted to clinical wards were included. Behavioral mapping was undertaken for each participant between 9AM and 4PM. The location, physical activity, daily activity, and company of participants were described. Barriers to physical activity were examined using linear regression analyses. Results: In total, 345 participants from 19 different wards were included. The mean (SD) age was 61 (16) …

Intracellular Hemin Is A Potent Inhibitor Of The Voltage-Gated Potassium Channel Kv10.1, Nirakar Sahoo, Kefan Yang, Alisa Bernert, Sandip M. Swain, Guido Gessner, Reinhard Kappl, Toni Kühl, Diana Imhof, Toshinori Hoshi, Roland Schönherr, Stefan H. Heinemann

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Heme, an iron-protoporphyrin IX complex, is a cofactor bound to various hemoproteins and supports a broad range of functions, such as electron transfer, oxygen transport, signal transduction, and drug metabolism. In recent years, there has been a growing recognition of heme as a non-genomic modulator of ion channel functions. Here, we show that intracellular free heme and hemin modulate human ether à go-go (hEAG1, Kv10.1) voltage-gated potassium channels. Application of hemin to the intracellular side potently inhibits Kv10.1 channels with an IC50 of about 4 nM under ambient and 63 nM under reducing conditions in a weakly voltage-dependent manner, …

Somatic Variants In Diverse Genes Leads To A Spectrum Of Focal Cortical Malformations, Dulcie Lai, Meethila Gade, Edward Yang, Hyun Yong Koh, Jinfeng Lu, Nicole M Walley, Anne F Buckley, Tristan T Sands, Cigdem I Akman, Mohamad A Mikati, Guy M Mckhann, James E Goldman, Peter Canoll, Allyson L Alexander, Kristen L Park, Gretchen K Von Allmen, Olga Rodziyevska, Meenakshi B Bhattacharjee, Hart G W Lidov, Hannes Vogel, Gerald A Grant, Brenda E Porter, Annapurna H Poduri, Peter B Crino, Erin L Heinzen

Faculty, Staff and Student Publications

Post-zygotically acquired genetic variants, or somatic variants, that arise during cortical development have emerged as important causes of focal epilepsies, particularly those due to malformations of cortical development. Pathogenic somatic variants have been identified in many genes within the PI3K-AKT-mTOR-signalling pathway in individuals with hemimegalencephaly and focal cortical dysplasia (type II), and more recently in SLC35A2 in individuals with focal cortical dysplasia (type I) or non-dysplastic epileptic cortex. Given the expanding role of somatic variants across different brain malformations, we sought to delineate the landscape of somatic variants in a large cohort of patients who underwent epilepsy surgery with hemimegalencephaly …

Organization Of The Gravity-Sensing System In Zebrafish, Zhikai Liu, David G C Hildebrand, Joshua L Morgan, Yizhen Jia, Nicholas Slimmon, Martha W Bagnall

2020-Current year OA Pubs

Motor circuits develop in sequence from those governing fast movements to those governing slow. Here we examine whether upstream sensory circuits are organized by similar principles. Using serial-section electron microscopy in larval zebrafish, we generated a complete map of the gravity-sensing (utricular) system spanning from the inner ear to the brainstem. We find that both sensory tuning and developmental sequence are organizing principles of vestibular topography. Patterned rostrocaudal innervation from hair cells to afferents creates an anatomically inferred directional tuning map in the utricular ganglion, forming segregated pathways for rostral and caudal tilt. Furthermore, the mediolateral axis of the ganglion …

The Complete Mitochondrial Genome Of Talpa Martinorum (Mammalia: Talpidae), A Mole Species Endemic To Thrace: Genome Content And Phylogenetic Considerations, S Demirtas, Mahir Budak, Ertan M. Korkmaz, Jeremy B. Searle, David T. Bilton, I Gunduz

School of Biological and Marine Sciences

The complete mitogenome sequence of Talpa martinorum, a recently described Balkan endemic mole, was assembled from next generation sequence data. The mitogenome is similar to that of the three other Talpa species sequenced to date, being 16,835 bp in length, and containing 13 protein-coding genes, two ribosomal RNA genes, 22 transfer RNA genes, an origin of L-strand replication, and a control region or D-loop. Compared to other Talpa mitogenomes sequenced to date, that of T. martinorum differs in the length of D-loop and stop codon usage. TAG and T-- are the stop codons for the ND1 and ATP8 genes, respectively, …

The Epistemology Of Complexity And "Doing" Interdisciplinarity, Sharon Woodill

Interface: The C3 Lab Knowledge Commons

Complexity is now well established as the driver of interdisciplinarity, but what this means for how knowledge is ‘done’ within Interdisciplinary Studies has not been well developed. This paper examines the theory of complexity and unpacks its epistemological implications for doing interdisciplinary work. The epistemology of complexity demands a cognitive toolkit that includes such things as open-mindedness, tolerance of uncertainty and ambiguity, and intellectual courage. This paper draws out these connections and suggests implications for curriculum development in Interdisciplinary Studies.

Adolescent Sleep Behavioral Interventions And Opportunities To Improve Cognitive Functioning: A Call For Action, Leonell Torres-Pagan, Angelica Terepka, Renata Vaysman, Nicole M. Velez-Agosto, John Usseglio, Ari Shechter

Journal of Applied Research on Children: Informing Policy for Children at Risk

Sleep is related to cognitive functioning, learning, and brain development in the adolescent population. Recent research indicates a rise in the presence of chronic sleep disorders such as insomnia in adolescents, particularly following the COVID-19 pandemic. Therefore, research on the effectiveness of sleep interventions for adolescents is necessary to guide treatment in adolescents. The authors conducted a systematic review of literature examining research on outcomes of treatment interventions for insomnia on sleep quality and cognitive functioning in adolescents. Results indicate a dearth of research examining effectiveness of treatment in adolescents, particularly in relation to the impact of such treatment on …

Exploring The Interpersonal Consequences Of Adverse Childhood Experiences In College Students, Jessica Criddle, Thomas B. Sease, Esther Malm

Faculty & Staff Research and Creative Activity

The Interpersonal Process Model of Intimacy characterizes intimacy as dyadic interpersonal interactions in which vulnerable behaviors are displayed and reinforced by suitable listeners. We posited that Adverse Childhood Experiences (ACEs) would foster avoidance of vulnerable speaker behaviors in dyadic exchanges, as seen in self-concealment, and that lower levels of ACEs would be associated with more self-disclosure. Correspondingly, we examined whether self-concealment and self-disclosure simultaneously mediated the relationship between ACEs and relationship closeness in college students. Results revealed that ACEs were significantly associated with more self-concealment only. After removing self-disclosure from the model, self-concealment mediated the relationship between ACEs and relationship …

Medical School Watercooler Newsletter - August 26, 2022, Lindsey Lyle

Watercooler Newsletter

This is the August 26, 2022 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents include:

• Contest supports Student-Run Free Clinic
• Register now: 30th annual OB-GYN conference
• Meet a Med Student: Jerry Andrews
• Faculty, staff and students present at international conference on Alzheimer’s disease
• CCTS Training Symposium set for Sept. 14-16

Faculty Handbook Section Iii- College Of Liberal Arts Policies And Procedures- Updated 8/26/2022, All Faculty

Faculty Handbooks

No abstract provided.

Decoupled Land And Ocean Temperature Trends In The Early-Middle Pleistocene, Hongxuan Lu, Weiguo Liu, Hong Yang, Qin Leng, Zhonghui Liu, Yunning Cao, Jing Hu, Weijuan Sheng, Huanye Wang, Zheng Wang, Zeke Zhang, Youbin Sun, Weijian Zhou, Zhisheng An

Science and Technology Department Faculty Journal Articles

Record of long-term land temperature changes remains ephemeral, discontinuous, and isolated, thus leaving the common view that Pleistocene land temperature evolution should have followed ocean temperatures unconfirmed. Here, we present a continuous land surface temperature reconstruction in the Asian monsoon region over the past 3.0 Myr based on the distribution of soil bacterial lipids from the Chinese Loess Plateau. The land temperature record indicates an unexpected warming trend over the Pleistocene, which is opposite to the cooling trend in Pleistocene ocean temperatures, resulting in increased land-sea thermal contrast. We propose that the previously unrecognized increase of land-sea thermal contrast during …

2022 Ursinus College Academic Convocation Program, Ursinus College

Academic Convocation Programs

This Ursinus College Academic Convocation program lists speakers and events for the opening of the 2022 academic year.

First Born Ceos And Credit Ratings, June Woo Park, Giseok Nam, Albert Tsang, Yung-Jae Lee

Barowsky School of Business | Faculty Scholarship

Our study examines whether CEOs’ birth order can predict firms’ credit ratings. Consistent with studies that document a positive relationship in the general population between being firstborn and being conservative, our study finds that firms managed by firstborn CEOs tend to have higher credit ratings than those managed by later-born CEOs. Our results are robust to controlling for additional personal CEO traits, such as political identity, and to using a propensity score matching sample. A change analysis supports the causality of the firstborn effect. We suggest that return on assets and free cash flow are possible channels through which firstborn …

Divergent Neural And Endocrine Responses In Wild-Caught And Laboratory-Bred Rattus Norvegicus, Joanna Jacob, Sally Watanabe, Jonathan Richardson, Nick Gonzales, Emily Ploppert, Garet Lahvis, Aaron Shiels, Sadie Wenger, Kelly Saverino, Janhavi Bhalerao, Brendan Crockett, Erin Burns, Olivia Harding, Krista Fischer-Stenger, Kelly Lambert

United States Department of Agriculture Wildlife Services: Staff Publications

Although rodents have represented the most intensely studied animals in neurobiological investigations for more than a century, few studies have systematically compared neural and endocrine differences between wild rodents in their natural habitats and laboratory strains raised in traditional laboratory environments. In the current study, male and female Rattus norvegicus rats were trapped in an urban setting and compared to weight-and sex-matched conspecifics living in standard laboratory housing conditions. Brains were extracted for neural assessments and fecal boli were collected for endocrine [corticosterone and dehydroepiandrosterone (DHEA)] assays. Additionally, given their role in immune and stress functions, spleen and adrenal weights …

Adaptation Of Quinoa (Chenopodium Quinoa Willd.) To Australian Environments, Richard Snowball, Harmohinder S. Dhammu, Mario Francesco D'Antuono, David Troldahl, Ian Biggs, Callen Thompson, Mark Warmington, Amanda Pearce, Darshan L. Sharma

Grain and Other Field Crops Research Articles

Quinoa is being evaluated in cropping systems in many countries outside of its natural range of South America. Very few attempts have been made by farmers or researchers to grow or evaluate quinoa under Australian environments. Given the growing popularity of quinoa with consumers, new commercial opportunities for farmers and international interest in the crop, it was timely to undertake a comprehensive evaluation of the potential of quinoa in Australia. Two advanced selections and nine germplasm lines (six of Chilean and three of Bolivian origin) identified in an earlier project were tested in 23 field trials at 14 locations on …

Review Of The Cybocephalidae (Coleoptera) Of North America And The West Indies With Descriptions Of Two New Species Of Cybocephalus Erichson, Trevor Randall Smith

Insecta Mundi

The nineteen species of Cybocephalidae (Coleoptera) occurring in North America and the West Indies (including Trinidad) are listed and keyed. Cybocephalus skelleyi new species and Cybocephalus edmondsoni new species are described, and Cybocephalus carrabeus T. R. Smith is found to be a new syn­onym of Cybocephalus geoffereysmithi T. R. Smith. Illustrations of morphological features, including detailed drawings of male genitalia, host records and distribution data, are provided.

The Referential Abbreviations Used By Linnaeus And Other Authors From 1758 Through 1779 For Describing Species Of Scarabaeoidea (Insecta: Coleoptera), Auke J. Hielkema

Insecta Mundi

A list of abbreviations regarding literature, collections and persons as used by early authors (1758–1779) of scarabaeoid beetles (Insecta: Coleoptera) is given together with modern referrals to the Literature Cited. Notes regarding referential errors are included. Hyperlinks to all mentioned and freely online available publications are provided.

The Association Between Child Behavior Problems And Parenting Stress In Families Of Children With Disabilities In The United Arab Emirates (Uae): Family Resilience Processes As Protective Factors, Sara Alansaari

Theses - ALL

No abstract provided.

Characterizing Microbiome Variation In Wild Populations Of Mosquito Species, Jane Pascar

Theses - ALL

No abstract provided.

Phytochemical Screening And In-Vitro Α-Glucosidase Inhibitory Activity Analysis Of Ethanol Extract Of Mangifera Quadrifida, Fadilah Fadilah

Indonesian Journal of Medical Chemistry and Bioinformatics

Abstract

Introduction: Type 2 Diabetes Mellitus (DM) is a metabolic disorder characterized by hyperglycemia caused by B cell dysfunction, insulin resistance, or both. Indonesia and worldwide have an increasing incidence that leads to a significant socio-economic burden. The effective treatment of Type 2 DM with minimal side effects is still challenging. This research aims to identify phytochemical properties in ethanol extract of Mangifera quadrifida and the effectivity as an alfa-glucosidase inhibitor beneficial to research on the treatment of type 2 DM.

Method: Mangifera quadrifida was extracted by ethanol as solvent. The phytochemical analysis is conducted by phytochemical screening methods and …

Dynamic Modeling Of Aba-Dependent Expression Of The Arabidopsis Rd29a Gene, Ruth Ndathe, Renee Dale, Naohiro Kato

Faculty Publications

The abscisic acid (ABA) signaling pathway is the key defense mechanism against drought stress in plants. In the pathway, signal transduction among four core proteins, pyrabactin resistance (PYR), protein phosphatase 2C (PP2C), sucrose-non-fermenting-1-related protein kinase 2 (SnRK2), and ABRE binding factor (ABF) leads to altered gene expression kinetics that is driven by an ABA-responsive element (ABRE). A most recent and comprehensive study provided data suggesting that ABA alters the expression kinetics in over 6,500 genes through the ABF-ABRE associations in Arabidopsis. Of these genes, termed ABA gene regulatory network (GRN), over 50% contain a single ABRE within 4 kb of …

The Marine Gastropod Conomurex Luhuanus (Strombidae) Has High-Resolution Spatial Vision And Eyes With Complex Retinas, Allison R. Irwin, Suzanne T. Williams, Daniel Isaac Speiser, Nicholas W. Roberts

Faculty Publications

All species within the conch snail family Strombidae possess large camera-type eyes that are surprisingly well-developed compared with those found in most other gastropods. Although these eyes are known to be structurally complex, very little research on their visual function has been conducted. Here, we use isoluminant expanding visual stimuli to measure the spatial resolution and contrast sensitivity of a strombid, Conomurex luhuanus. Using these stimuli, we show that this species responds to objects as small as 1.06 deg in its visual field. We also show that C. luhuanus responds to Michelson contrasts of 0.07, a low contrast sensitivity …

Communities Moving Past The Daddy Daughter Dance: Adapting Gender-Exclusive Events For The 21st Century, Ezra Temko, Emily Love, Destiny Baxter, Heidi Masching, Adam Loesch

SIUE Faculty Research, Scholarship, and Creative Activity

Executive Summary

Parent-child community events like father-daughter dances are a celebrated tradition in many communities. However, when these events specify the gender of who can participate, they exclude many families. They also tend to reinforce gender stereotypes (e.g., a dance for girls and a sports event for boys), and are legally questionable for public school and associated P.T.A./P.T.O. sponsors that may be violating federal Title IX requirements and for local governments that may be violating the 14^th Amendment to the U.S. Constitution’s Equal Protection Clause.

Contemporary U.S. society is made up of families that come in diverse forms and …

Design Of Novel Metalloenzymes And Investigation Of Protein-Metal Interactions, Alona Kulesha

Dissertations - ALL

Metalloproteins are the proteins that utilize metals or metal complexes as cofactors and exhibit a wide range of functions from oxygen transport and regulation of transcription to hydroxylation of alkanes and water splitting, even though they employ a limited set of metals and metal-binding ligands. The investigation of metalloprotein amino acid sequence, structure and function relationships can uncover the principles behind natural metalloprotein design and opens the possibility of their implication as scaffolds for the design of novel catalysts and biomaterials. Protein engineering is a set of techniques that allows to install new functionalities into existing proteins or to design …

Advanced Lithium Metal Batteries: Functional Electrolyte Additive And Lithium Metal/Solid-State Electrolyte Interface Engineering, Abiral Baniya

Dissertations - ALL

Majority of the energy in current world is produced and consumed by burning non-renewable fossil fuel sources such as coal, oil, and natural gas, etc. It is taking a toll on our planet earth due to high rates of carbon and greenhouse emissions. This calls for an urgent need of energy transition from conventional fossil fuel to renewable and sustainable energy sources such as solar, wind, geothermal, etc. However, harnessing energy from such renewables are constrained by their intermittency and non-dispatchability, requiring some sort of efficient energy storage systems that can provide continuous energy supply. Batteries in general are considered …

Implementing The Mindfulness-Based Kindness Curriculum In An Inclusive Setting: Effects On Prosocial Behavior, Emily Cary

Dissertations - ALL

Low rates of prosocial behavior are associated with poor academic, emotional, and behavioral outcomes, including physical aggression, externalizing problems, criminal justice convictions, lower academic achievement, and more peer rejection. Using a cluster randomized control trial, this study examined the effects of the mindfulness-based Kindness Curriculum (N = 26), compared to a matched control condition consisting of a social and emotional learning (SEL) curriculum, Merrell’s Strong Start (N = 20). Outcome measures included the Strengths and Difficulties Questionnaire and the Head Shoulders Knees and Toes task, which are measures of prosocial behavior including self-regulatory skills. These assessments were administered to 5 …

Do Adverse Childhood Experiences Mediate The Relationship Between Autistic Traits And Borderline Personality Traits?, Alyne Rodrigues

Dissertations - ALL

Background: Previous studies have found comorbid autism spectrum disorder (ASD) and borderline personality disorder (BPD) diagnoses in clinical samples, higher autistic traits in individuals with BPD compared to control groups, and co-occurrence of autistic traits and BPD traits in community samples. Adverse childhood experiences (ACEs) are highly prevalent among autistic individuals and individuals diagnosed with BPD. However, to date, cumulative ACEs have been neglected as a potential mediator of the association between ASD and BPD. The present preliminary cross-sectional study examined whether retrospective self-reported ACEs, before 18 years of age, explained the relationship between current self-reported autistic traits and current …