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September 2022 Table Of Contents Newsletter - Research Help, Tiffany Hebb

Table of Contents Newsletter

Like everything else, the reference desk and the way we provide service at it has changed. What hasn’t changed is the need for assistance with difficult information seeking tasks. Libraries receive fewer questions in the background information area (e.g. dates, places) these days but spend time on more complex research questions. DePauw Libraries seek to meet the needs of researchers by staffing the research desk with trained students and making librarians readily available for one-on-one collaboration.

Proteome Of The Wood Decay Fungus Fomitopsis Pinicola Is Altered By Substrate, Grzegorz Sabat, Steven Ahrendt, Baojun Wu, Jill Gaskell, Benjamin W. Held, Cristina Toapanta, Thu V. Vuong, Anna Lipzen, Jiwei Zhang, Jonathan S. Schilling, Emma Master, Igor V. Grigoriev, Robert A. Blanchette, David S. Hibbett, Jennifer Bhatnagar, Daniel Cullen

Biology

The brown rot fungus Fomitopsis pinicola efficiently depolymerizes wood cellulose via the combined activities of oxidative and hydrolytic enzymes. Mass spectrometric analyses of culture filtrates identified specific proteins, many of which were differentially regulated in response to substrate composition.

Genetic Loci And Prioritization Of Genes For Kidney Function Decline Derived From A Meta-Analysis Of 62 Longitudinal Genome-Wide Association Studies, Mathias Gorski, Humaira Rasheed, Alexander Teumer, Laurent F Thomas, Sarah E Graham, Gardar Sveinbjornsson, Thomas W Winkler, Felix Günther, Klaus J Stark, Jin-Fang Chai, Bamidele O Tayo, Matthias Wuttke, Yong Li, Adrienne Tin, Tarunveer S Ahluwalia, Johan Ärnlöv, Bjørn Olav Åsvold, Stephan J L Bakker, Bernhard Banas, Nisha Bansal, Mary L Biggs, Ginevra Biino, Michael Böhnke, Eric Boerwinkle, Erwin P Bottinger, Hermann Brenner, Ben Brumpton, Robert J Carroll, Layal Chaker, John Chalmers, Miao-Li Chee, Miao-Ling Chee, Ching-Yu Cheng, Audrey Y Chu, Marina Ciullo, Massimiliano Cocca, James P Cook, Josef Coresh, Daniele Cusi, Martin H De Borst, Frauke Degenhardt, Kai-Uwe Eckardt, Karlhans Endlich, Michele K Evans, Mary F Feitosa, Andre Franke, Sandra Freitag-Wolf, Christian Fuchsberger, Piyush Gampawar, Ron T Gansevoort, Mohsen Ghanbari, Sahar Ghasemi, Vilmantas Giedraitis, Christian Gieger, Daniel F Gudbjartsson, Stein Hallan, Pavel Hamet, Asahi Hishida, Kevin Ho, Edith Hofer, Bernd Holleczek, Hilma Holm, Anselm Hoppmann, Katrin Horn, Nina Hutri-Kähönen, Kristian Hveem, Shih-Jen Hwang, M Arfan Ikram, Navya Shilpa Josyula, Bettina Jung, Mika Kähönen, Irma Karabegović, Chiea-Chuen Khor, Wolfgang Koenig, Holly Kramer, Bernhard K Krämer, Brigitte Kühnel, Johanna Kuusisto, Markku Laakso, Leslie A Lange, Terho Lehtimäki, Man Li, Wolfgang Lieb, Lifelines Cohort Study, Lars Lind, Cecilia M Lindgren, Ruth J F Loos, Mary Ann Lukas, Leo-Pekka Lyytikäinen, Anubha Mahajan, Pamela R Matias-Garcia, Christa Meisinger, Thomas Meitinger, Olle Melander, Yuri Milaneschi, Pashupati P Mishra, Nina Mononen, Andrew P Morris, Josyf C Mychaleckyj, Girish N Nadkarni, Mariko Naito, Masahiro Nakatochi, Mike A Nalls, Matthias Nauck, Kjell Nikus, Boting Ning, Ilja M Nolte, Teresa Nutile, Michelle L O'Donoghue, Jeffrey O'Connell, Isleifur Olafsson, Marju Orho-Melander, Afshin Parsa, Sarah A Pendergrass, Brenda W J H Penninx, Mario Pirastu, Michael H Preuss, Bruce M Psaty, Laura M Raffield, Olli T Raitakari, Myriam Rheinberger, Kenneth M Rice, Federica Rizzi, Alexander R Rosenkranz, Peter Rossing, Jerome I Rotter, Daniela Ruggiero, Kathleen A Ryan, Charumathi Sabanayagam, Erika Salvi, Helena Schmidt, Reinhold Schmidt, Markus Scholz, Ben Schöttker, Christina-Alexandra Schulz, Sanaz Sedaghat, Christian M Shaffer, Karsten B Sieber, Xueling Sim, Mario Sims, Harold Snieder, Kira J Stanzick, Unnur Thorsteinsdottir, Hannah Stocker, Konstantin Strauch, Heather M Stringham, Patrick Sulem, Silke Szymczak, Kent D Taylor, Chris H L Thio, Johanne Tremblay, Simona Vaccargiu, Pim Van Der Harst, Peter J Van Der Most, Niek Verweij, Uwe Völker, Kenji Wakai, Melanie Waldenberger, Lars Wallentin, Stefan Wallner, Judy Wang, Dawn M Waterworth, Harvey D White, Cristen J Willer, Tien-Yin Wong, Mark Woodward, Qiong Yang, Laura M Yerges-Armstrong, Martina Zimmermann, Alan B Zonderman, Tobias Bergler, Kari Stefansson, Carsten A Böger, Cristian Pattaro, Anna Köttgen, Florian Kronenberg, Iris M Heid

Faculty, Staff and Student Publications

Estimated glomerular filtration rate (eGFR) reflects kidney function. Progressive eGFR-decline can lead to kidney failure, necessitating dialysis or transplantation. Hundreds of loci from genome-wide association studies (GWAS) for eGFR help explain population cross section variability. Since the contribution of these or other loci to eGFR-decline remains largely unknown, we derived GWAS for annual eGFR-decline and meta-analyzed 62 longitudinal studies with eGFR assessed twice over time in all 343,339 individuals and in high-risk groups. We also explored different covariate adjustment. Twelve genome-wide significant independent variants for eGFR-decline unadjusted or adjusted for eGFR-baseline (11 novel, one known for this phenotype), including nine …

Major Pathologic Response And Prognostic Score Predict Survival In Patients With Lung Cancer Receiving Neoadjuvant Chemotherapy, Apar Pataer, Annikka Weissferdt, Arlene M Correa, Ara A Vaporciyan, Boris Sepesi, John V Heymach, Sabina Berezowska, Tina Cascone, Stephen G Swisher

Faculty, Staff and Student Publications

INTRODUCTION: Complete pathologic response (CPR) is an acceptable surrogate for survival in clinical trials but it occurs infrequently in patients with NSCLC receiving neoadjuvant chemotherapy (NCT). Therefore, we studied the impact of major pathologic response (MPR) for predicting survival of patients with NSCLC receiving NCT. We also tested a newly reported scoring system-the prognostic score (PRSC)-which combines T category, lymph node status, and MPR status.

METHODS: We analyzed CPR and MPR, defined as 0% and less than or equal to 10% viable tumor cells, respectively, in 339 patients with NSCLC with various histologic types who had been treated with NCT …

Tumor Immune Microenvironment Changes By Multiplex Immunofluorescence Staining In A Pilot Study Of Neoadjuvant Talazoparib For Early-Stage Breast Cancer Patients With A Hereditary Brca Mutation, Tapsi Kumar, Evie Hobbs, Fei Yang, Jeffrey T Chang, Alejandro Contreras, Edwin Roger Parra Cuentas, Haven Garber, Sanghoon Lee, Yiling Lu, Marion E Scoggins, Beatriz E Adrada, Gary J Whitman, Banu K Arun, Elizabeth A Mittendorf, Jennifer K Litton

Faculty, Staff and Student Publications

PURPOSE: The immunological profile of early-stage breast cancer treated with neoadjuvant PARP inhibitors has not been described. The aim of this study was to delineate the changes in the tumor immune microenvironment (TiME) induced by talazoparib.

PATIENTS AND METHODS: Patients with operable germline BRCA1/2 pathogenic variant (gBRCA1/2+) breast cancer were enrolled in a feasibility study of neoadjuvant talazoparib. Thirteen patients who received 8 weeks of neoadjuvant talazoparib were available for analysis, including 11 paired pre- and post-talazoparib core biopsies. Treatment-related changes in tumor-infiltrating lymphocytes were examined and immune cell phenotypes and their spatial distribution in the TiME were identified and …

Confirming Subarachnoid Hemorrhage Induction In The Endovascular Puncture Mouse Model, Ari Dienel, Sung-Ha Hong, Jose Guzman, Kumar T Peeyush, Spiros L Blackburn, Devin W Mcbride

Faculty, Staff and Student Publications

Background and purpose: Experimental studies of subarachnoid hemorrhage (SAH) using the endovascular perforation model routinely use either cerebral blood flow (CBF) or intracranial pressure (ICP) monitoring to confirm SAH induction. We designed this study to test the hypothesis that contralateral CBF is a better marker of SAH induction than ipsilateral CBF.

Methods: Sixty-eight adult C57BL/6J mice were subjected to endovascular perforation. Mice were monitored using laser Doppler (for relative CBF) or ICP probes.

Results: The ipsilateral CBF significantly decreased prior to ICP rising. However, reduction of the CBF in the contralateral hemisphere occurred at the same time as the rise …

Idh1 Prr32h Ctdna And D-2-Hydroxyglutarate As Csf Biomarkers In Patients With Idh-Mutant Gliomas, Yoko Fujita, Luis Nunez-Rubiano, Antonio Dono, Allison Bellman, Mauli Shah, Juan C Rodriguez, Vasanta Putluri, Abu Hena Mostafa Kamal, Nagireddy Putluri, Roy F Riascos, Jay-Jiguang Zhu, Yoshua Esquenazi, Leomar Y Ballester

Faculty, Staff and Student Publications

INTRODUCTION: We aimed to evaluate IDH1 p.R132H mutation and 2-hydroxyglutarate (2HG) in cerebrospinal fluid (CSF) as biomarkers for patients with IDH-mutant gliomas.

METHODS: CSF was collected from patients with infiltrating glioma, and 2HG levels were measured by liquid chromatography-mass spectrometry. IDH1 p.R132H mutant allele frequency (MAF) in CSF-ctDNA was measured by digital droplet PCR (ddPCR). Tumor volume was measured from standard-of-care magnetic resonance images.

RESULTS: The study included 48 patients, 6 with IDH-mutant and 42 with IDH-wildtype gliomas, and 57 samples, 9 from the patients with IDH-mutant and 48 from the patients with IDH-wildtype gliomas. ctDNA was detected in 7 …

Plasmonic Gadolinium Oxide Nanomatryoshkas: Bifunctional Magnetic Resonance Imaging Enhancers For Photothermal Cancer Therapy, Luke Henderson, Oara Neumann, Yara Kadria-Vili, Burak Gerislioglu, James Bankson, Peter Nordlander, Naomi J Halas

Faculty, Staff and Student Publications

Nanoparticle-assisted laser-induced photothermal therapy (PTT) is a promising method for cancer treatment; yet, visualization of nanoparticle uptake and photothermal response remain a critical challenge. Here, we report a magnetic resonance imaging-active nanomatryoshka (Gd2O3-NM), a multilayered (Au core/Gd2O3 shell/Au shell) sub-100 nm nanoparticle capable of combining T1 MRI contrast with PTT. This bifunctional nanoparticle demonstrates an r1 of 1.28 × 108 mM-1 s-1, an MRI contrast enhancement per nanoparticle sufficient for T1 imaging in addition to tumor ablation. Gd2O3-NM also shows excellent stability in an acidic environment, retaining 99% of the internal Gd(3). This report details the synthesis and characterization of …

Automation Of Radiation Treatment Planning For Rectal Cancer, Kai Huang, Prajnan Das, Adenike M Olanrewaju, Carlos Cardenas, David Fuentes, Lifei Zhang, Donald Hancock, Hannah Simonds, Dong Joo Rhee, Sam Beddar, Tina M Briere, Laurence Court

Faculty, Staff and Student Publications

PURPOSE: To develop an automated workflow for rectal cancer three-dimensional conformal radiotherapy (3DCRT) treatment planning that combines deep learning (DL) aperture predictions and forward-planning algorithms.

METHODS: We designed an algorithm to automate the clinical workflow for 3DCRT planning with field aperture creations and field-in-field (FIF) planning. DL models (DeepLabV3+ architecture) were trained, validated, and tested on 555 patients to automatically generate aperture shapes for primary (posterior-anterior [PA] and opposed laterals) and boost fields. Network inputs were digitally reconstructed radiographs, gross tumor volume (GTV), and nodal GTV. A physician scored each aperture for 20 patients on a 5-point scale (>3 …

Regulatory Compliance Of Labels And Product Information Leaflets For Medicines Distributed In The Private Sector In South Sudan, Stephen Mawa, Zita Ekeocha, Stephen Byrn, Kari Clase

BIRS Africa Technical Report Papers

Patient information leaflets (PILs) and labels are important for rational use of medicines as they provide additional information for patients on the medicines dispensed to them. In developing countries, this potential cannot be fully harnessed unless manufacturers provide medicines with labels and PILs that meet regulatory standards for content and user-friendliness. In South Sudan, it is not known if manufacturers uphold standards of these labels and PILs once their products are approved for distribution in the country.

This study explored the degree to which medicines distributed in South Sudan comply with regulatory requirements for labels and PILs. A cross-sectional survey …

Development Of An Assessment Tool For Good Distribution Practice For A Regulatory Agency In West Africa, Ukamaka Gladys Okafor, Zita Ekeocha, Stephen Byrn, Kari Clase, Solomon Shiihii

BIRS Africa Technical Report Papers

Good Distribution Practice (GDP) refers to the regulatory guidelines governing the wholesale and distribution of medicinal products to ensure that their quality and integrity are maintained throughout the supply chain from the manufacturer to the end users. A standard assessment tool for GDP is necessary in order to conduct a robust assessment on GDP on pharmaceutical industries. The observed agency’s policy and operational documents in addition to GDP Guidelines from World Health Organization and related organizations from various countries were reviewed. The observed Regulatory Agency does not have a separate assessment tool for GDP inspection. Few core GDP parameters are …

Patch-Burn Grazing Impacts Forage Resources In Subtropical Humid Grazing Lands, Elizabeth H. Boughton, Nuria Gomez-Casanovas, Hilary Swain, Carl Bernacchi, Raoul K. Boughton, Keith Brinsko, Haoyu Li, Alan Rivero, Evan H. Delucia, Jed Sparks

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

Subtropical humid grazing lands represent a large global land use and are important for livestock production, as well as supplying multiple ecosystem services. Patch-burn grazing (PBG) management is applied in temperate grazing lands to enhance environmental and economic sustainability; however, this management system has not been widely tested in subtropical humid grazing lands. The objective of this study was to determine how PBG affected forage resources, in comparison with the business-as-usual full-burn (FB) management in both intensively managed pastures (IMP) and seminative (SN) pastures in subtropical humid grazinglands. We hypothesized that PBG management would create patch contrasts in forage quantity …

Pgc-1Α Overexpression Is Not Sufficient To Mitigate Cancer Cachexia In Either Male Or Female Mice, Francielly Morena Da Silva, Megan Rosa-Caldwell, Eleanor R. Schrems, Lauren Martinez, Madeline G. Amos, Seongkyun Lim, Ana Regina Cabrera, Jacob L. Brown, Tyrone A. Washington, Nicholas P. Greene

Health, Human Performance and Recreation Faculty Publications and Presentations

Cancer cachexia (CC) accounts for 20%–40% of cancer-related deaths. Mitochondrial aberrations have been shown to precede muscle atrophy in different atrophy models, including cancer. Therefore, this study investigated potential protection from the cachectic phenotype through overexpression of peroxisome proliferator-activated receptor γ coactivator-1 α (PGC-1α). First, to establish potential of mitochondria-based approaches we showed that the mitochondrial antioxidant MitoTEMPO (MitoT) attenuates myotube atrophy induced by Lewis lung carcinoma (LLC) cell conditioned media. Next, cachexia was induced in muscle-specific PGC-1α overexpressing (MCK-PCG1α) or wildtype (WT) littermate mice by LLC implantation. MCK-PCG1α did not protect LLC-induced muscle mass loss. In plantaris, Atrogin mRNA …

Elucidating Thermochemical Pretreatment Effectiveness Of Different Particle-Size Switchgrass For Cellulosic Ethanol Production, Jikai Zhao, Yang Yang, Meng Zhang, Charles W. Rice, Donghai Wang

School of Earth, Environmental, & Marine Sciences Faculty Publications

Effects of switchgrass particle sizes (pretreatments were investigated. As particle size increased, glucan, xylan, and lignin contents in raw switchgrass augmented from 30.32% to 32.02%, 18.44% to 19.03%, and 14.78% to 15.33%, respectively. Glucan and xylan (58.54–60.94% and 18.55–20.01%) contents in NaOH pretreated switchgrass and their recoveries (91.95–94.69% and 47.91–52.31%) increased. The highest glucan content (55.76%) and recovery (79.72%) in H2SO4 pretreated switchgrass were reached by middle particle size. The lowest (59.39% for H2SO4 and 58.99% for NaOH) and highest (65.23% for H2SO4 and 66.15% for NaOH) CrI values were obtained from middle and small particle sizes, respectively. …

Oxidative Stress Is A Potential Cost Of Synchronous Nesting In Olive Ridley Sea Turtles, B. Gabriela Arango, David C. Ensminger, Diana Daniela Moreno-Santillán, Martha Harfush-Meléndez, Elpidio Marcelino López-Reyes, José Alejandro Marmolejo-Valencia, Horacio Merchant-Larios, Daniel E. Crocker, José Pablo Vázquez-Medina

Faculty Research, Scholarly, and Creative Activity

Olive ridley sea turtles, Lepidochelys olivacea, exhibit a polymorphic reproductive behavior, nesting solitarily or in mass aggregations termed “arribadas”, where thousands of individuals nest synchronously. Arribada nesting provides fitness benefits including mate finding during nearshore aggregations and predator satiation at the time of hatching, but it is unknown if such benefits come with a physiological cost. We used plasma metabolite profiling, stable isotope analysis, biochemical and endocrine assays to test whether metabolic parameters differ between nesting modes, and if arribada nesting is associated with increased levels of oxidative damage compared to solitary nesting. Arribada nesters were bigger and had higher …

Climate‐Driven Shifts In Kelp Forest Composition Reduce Carbon Sequestration Potential, Luka Seamus Wright, Albert Pessarrodona, A Foggo

School of Biological and Marine Sciences

The potential contribution of kelp forests to blue carbon sinks is currently of great interest but interspecific variance has received no attention. In the temperate Northeast Atlantic, kelp forest composition is changing due to climate-driven poleward range shifts of cold temperate Laminaria digitata and L. hyperborea and warm temperate L. ochroleuca. To understand how this might affect the carbon sequestration potential of this ecosystem, we quantified interspecific differences in carbon export and decomposition alongside changes in detrital photosynthesis and biochemistry. We found that while warm temperate kelp exports up to 71% more carbon per plant, it decomposes up to 155% …

Unreliable Automated Complete Blood Count Results: Causes, Recognition, And Resolution, Gene Gulati, Guldeep Uppal, Jerald Z. Gong

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Automated hematology analyzers generate accurate complete blood counts (CBC) results on nearly all specimens. However, every laboratory encounters, at times, some specimens that yield no or inaccurate result(s) for one or more CBC parameters even when the analyzer is functioning properly and the manufacturer's instructions are followed to the letter. Inaccurate results, which may adversely affect patient care, are clinically unreliable and require the attention of laboratory professionals. Laboratory professionals must recognize unreliable results, determine the possible cause(s), and be acquainted with the ways to obtain reliable results on such specimens. We present a concise overview of the known causes …

Differentiation And Classification Of Productive Efficiency Of Chicken Farms Using Logistic Regression And Linear Discriminant Analysis, Eman Abo Elfadl, Hend Radwan, Usama Abou-Ismail

Mansoura Veterinary Medical Journal

This study was carried out to compare the accuracy of linear discriminant analysis (LDA) and binary logistic regression (BLR) in classification of level of production in layers (high and low) as a dependent variable using breed, total ration, number of mortality, marketing weight and marketing age as independent variables. Regarding the assumptions of each method, LDA and BLR were also compared with respect to the effect of sample size with consecration to lack of multivariate normality of predictors. Procedures: Record data of 12500 layers were collected from private farms in Dakahlia Governorate during the period from 2018 to 2020). The …

Teaching And Designing Culturally Responsive Experiences Using Cross-Media Film In Higher Education, Edward Cromarty, Mary Alice Young, Simone Elias

Journal of Research Initiatives

This paper examined the pedagogical use of cross-media film in higher education, as it highlighted cross-media in implementing a Culturally Responsive approach to enhance social justice learning in the classroom. The findings demonstrated the potential of cross-media film to engage learners through cultural relevance for the 21st century. The findings also considered that the Culturally Responsive approach may constitute a fourth pillar of the three epistemologies through research and suggestions for culturally responsive teaching practices.

The Impacts Of Problematic Social Media Use On Youths: Evaluation And Treatment Recommendations, Carianne Archer

Dissertations

Youths’ frequency and time spent on social media continues to increase over the years parallel to the growing concern of the status of the mental health of youth. This critical literature review project focuses on the impacts that social media use has on youth (ages 8 to 18 years) and what methods of evaluation and treatment are being used clinically, with recommendations provided to clinicians based on the available literature. The questions that guided this review included: What are the impacts of social media on the self-concept and interpersonal functioning of youths?; What clinical presentations are associated with youths who …

Impact Of Immigration Parent-Child Separation Policies On Children’S Attachment Experiences, Daisy Casasnovas

Dissertations

This critical literature review (CRP) project explores the consequences of child-parent separation by deportation laws. Considering the number of Latinx immigrant families immigrating to the United States, this review focused on how the unexpected separation by deportation impacted immigrant families and how these separations affect their children’s development, attachment style, and overall well-being. The review explored the short- and long-term consequences for immigrant children and their families, including children who are U.S.-born and remain in the country without their parents. Results from the review indicate an extensive and significant impact on attachment style and overall developmental impairments. The unexpected separation …

Exploring Metapopulation-Scale Suppression Alternatives For A Global Invader In A River Network Experiencing Climate Change, Brian D. Healy, Phaedra Budy, Charles B. Yackulic, Brendan P. Murphy, Robert C. Schelly, Mark C. Mckinstry

Wildland Resources Faculty Publications

Invasive species can dramatically alter ecosystems, but eradication is difficult, and suppression is expensive once they are established. Uncertainties in the potential for expansion and impacts by an invader can lead to delayed and inadequate suppression, allowing for establishment. Metapopulation viability models can aid in planning strategies to improve responses to invaders and lessen invasive species’ impacts, which may be particularly important under climate change. We used a spatially-explicit metapopulation viability model to explore suppression strategies for ecologically-damaging invasive brown trout (Salmo trutta), established in the Colorado River and a tributary within Grand Canyon National Park. Our goals …

Context For Reproducibility And Replicability In Geospatial Unmanned Aircraft Systems, Cassandra Howe, Jason A. Tullis

Geosciences Faculty Publications and Presentations

Multiple scientific disciplines face a so-called crisis of reproducibility and replicability (R&R) in which the validity of methodologies is questioned due to an inability to confirm experimental results. Trust in information technology (IT)-intensive workflows within geographic information science (GIScience), remote sensing, and photogrammetry depends on solutions to R&R challenges affecting multiple computationally driven disciplines. To date, there have only been very limited efforts to overcome R&R-related issues in remote sensing workflows in general, let alone those tied to unmanned aircraft systems (UAS) as a disruptive technology. This review identifies key barriers to, and suggests best practices for, R&R in geospatial …

Methods For Bioconjugation Of Biochemical Sensors Based On Metallic Nanoparticles, Jacob Rolin

Summer Community of Scholars Posters (RCEU and HCR Combined Programs)

No abstract provided.

Characterizing The Serum Resistance Function Of Plasmid-Encoded Virulence Factor Trat, Chaehee Lim

Summer Community of Scholars Posters (RCEU and HCR Combined Programs)

No abstract provided.

Assessing Biochemistry Students’ Use Of Metabolic Pathway Entities, Nina Fortier

Summer Community of Scholars Posters (RCEU and HCR Combined Programs)

No abstract provided.

Assessing Undergraduate Expression Of Biochemical Mechanisms, Lauren Richardson

Summer Community of Scholars Posters (RCEU and HCR Combined Programs)

No abstract provided.

Work

In Case You Missed It

SEPTEMBER 2022

Epicardial Adipose Tissue Thickness And Growth Differentiation Factor 15 In Axial Spondyloarthritis: A Cross-Sectional Study, Mehmet Okçu, Fatmanur A. Koçak, Senem Şaş, Kenan Güçlü

Saudi Medical Journal

Objectives: To investigate growth differentiation factor-15 (GDF-15) levels and the thickness of epicardial adipose tissue (EAT) in patients with axial spondyloarthritis (axSpA) and to evaluate their relationship with functional status, disease activity, disease duration, and the type of medical treatment received by the patients. Methods: This cross-sectional study was carried out at Kırşehir Ahievran University School of Medicine between February and June 2020. Twenty-nine healthy controls and 44 patients with axSpA were included in the study. Gender, age, erythrocyte sedimentation rate, GDF-15, body mass index, complete blood count, ejection fraction, the EAT thickness, and C-reactive protein of all participants were …

Why Do Men Face A Higher Risk Of Most Types Of Cancer Than Women?

Saudi Medical Journal

No abstract provided.