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Articles 6331 - 6360 of 32034
Full-Text Articles in Entire DC Network
Behavioral State-Specific Northern Bobwhite Chick Resource Selection, Justin N. Hill, Theron M. Terhune Ii, James A. Martin
Behavioral State-Specific Northern Bobwhite Chick Resource Selection, Justin N. Hill, Theron M. Terhune Ii, James A. Martin
National Quail Symposium Proceedings
Determining resource selection rates for all life stages of a species is critical to enable a holistic management approach that focuses on bolstering populations across all life stages. Moreover, tying these selection rates to specific life history needs (e.g., foraging, roosting, and loafing) can provide valuable information to guide management practices. Northern bobwhite (Colinus virginianus; hereafter, bobwhite), a gallinaceous species of North America, has experienced steady population declines throughout much of its range over the last 50 years. Although the species has been well studied, chick ecology is still relatively unknown. We studied bobwhite chick resource selection on …
Measuring Multiple Demographic Rates In Two Populations Of Northern Bobwhite, Alexander L. Jackson, D. Clay Sisson, Justin A. Rectenwald
Measuring Multiple Demographic Rates In Two Populations Of Northern Bobwhite, Alexander L. Jackson, D. Clay Sisson, Justin A. Rectenwald
National Quail Symposium Proceedings
Demographic rates of northern bobwhite (Colinus virginianus; hereafter, bobwhite) may vary spatially and temporally, and understanding the significance of these individual rates to population performance is critically important to bobwhite management. We present descriptive evidence from 2 populations that were simultaneously monitored from 2015–2020 that suggests different demographic rates can be more important to population performance than other demographic rates within the same region. Our objective was to understand the relative importance of various demographic rates to population performance in separate and seemingly stable populations. We monitored bobwhite seasonal survival and reproductive demographics on 2,475 bobwhites via radio-telemetry …
Diurnal Occurrence Of Great-Horned Owls On Northern Bobwhite Hunting Properties In Southwest Georgia, Justin A. Rectenwald, Philip M. Coppola, Theron M. Terhune Ii, D. Clay Sisson, James A. Martin
Diurnal Occurrence Of Great-Horned Owls On Northern Bobwhite Hunting Properties In Southwest Georgia, Justin A. Rectenwald, Philip M. Coppola, Theron M. Terhune Ii, D. Clay Sisson, James A. Martin
National Quail Symposium Proceedings
Understanding interactions between prey species and their predators is essential to discerning the ecology and management fundamentals of a species. Great-horned owls (Bubo virginianus) have long been considered an opportunistic predator of northern bobwhite (Colinus virginianus; hereafter, bobwhite) and recent studies have demonstrated that bobwhite survival is reduced at higher great-horned owl densities (Rectenwald et al. 2021). Managers on quail properties often mechanically remove live oak (Quercus virginiana) hammocks as part of larger predation management plans to reduce the amount of suitable predator habitat. While scattered live oaks are typically left for aesthetic purposes, …
Breeding Season Survival And Reproduction In A High-Density Bobwhite Population: A Case Study, William E. Palmer, Shane D. Wellendorf, D. Clay Sisson
Breeding Season Survival And Reproduction In A High-Density Bobwhite Population: A Case Study, William E. Palmer, Shane D. Wellendorf, D. Clay Sisson
National Quail Symposium Proceedings
The demographic behavior of northern bobwhite (Colinus virginianus; hereafter, bobwhite) populations at high densities could provide important insights into why bobwhite populations fluctuate. Therefore, we documented breeding season demographics of bobwhites to understand how prebreeding density influenced reproductive effort and postbreeding density on an intensively managed property in Leon County, Florida, USA, 2002–2006. We estimated prebreeding bobwhite density each April using multi-observer strip-transects and postbreeding densities each November using covey call grid surveys. We radio-tagged 217 bobwhites in March and located bobwhites at least 5 days/week, 15 April–30 September to determine vital rates. Prebreeding density ranged from 1.5–8.6 …
Home Range And Space Use Of Northern Bobwhite Under Two Different Management Models In Southwestern Missouri, Thomas R. Thompson, Frank L. Loncarich, R. Kyle Hedges
Home Range And Space Use Of Northern Bobwhite Under Two Different Management Models In Southwestern Missouri, Thomas R. Thompson, Frank L. Loncarich, R. Kyle Hedges
National Quail Symposium Proceedings
Northern bobwhite (Colinus virginianus; hereafter, bobwhite) management in Missouri, USA has traditionally been focused on providing an interspersion of grass, crop, old field, and woody cover juxtaposed to disked idle areas and food plots to maintain bobwhite populations. This traditional model is implemented with the goal of providing all essential habitat components within 40-acre blocks throughout a larger area used by a population. While this model can produce usable bobwhite space in agriculture-dominated landscapes, it may not be the most effective or efficient approach to producing and maintaining bobwhite in grassland-dominated landscapes. In southwestern Missouri native tallgrass prairie …
Nest Hatch Chronology Of Northern Bobwhite And Implications For Management, Frank L. Loncarich, R. Kyle Hedges
Nest Hatch Chronology Of Northern Bobwhite And Implications For Management, Frank L. Loncarich, R. Kyle Hedges
National Quail Symposium Proceedings
Managers in Missouri, USA, and in other Midwestern states have long operated under the belief that the peak of nest hatching for northern bobwhite (Colinus virginianus; hereafter, bobwhite) is 15 June. Though it is widely understood that bobwhite nests hatch throughout the summer, many management decisions are made based on the accepted peak. Fully understanding the dynamics behind bobwhite nest timing is critical, as management activities in nesting cover during summer are common. To better understand nest chronology, we used radio-telemetry to monitor nest incubation initiation, hatch date, and renesting rate on 6 conservation areas in southwestern Missouri …
A Monitoring Program To Evaluate The Coastal Grassland Restoration Incentive Program, Stephen J. Demaso, William G. Vermillion, Mark W. Parr
A Monitoring Program To Evaluate The Coastal Grassland Restoration Incentive Program, Stephen J. Demaso, William G. Vermillion, Mark W. Parr
National Quail Symposium Proceedings
The Gulf Coast Joint Venture (GCJV) is a regionally based, biologically driven, landscape-oriented volunteer partnership of private, state, and federal conservation organizations dedicated to the delivery of habitat important to priority bird species. The GCJV partnership’s Coastal Grassland Restoration Incentive Program (C-GRIP) provides financial incentives to private landowners for conducting habitat treatments that address the greatest limiting factor(s) to providing suitable grassland bird habitat on their property. The C-GRIP program is a way for the GCJV to deliver bird habitat to meet planning objectives for grassland birds, including northern bobwhite (Colinus virginianus). Our monitoring objective is to evaluate …
Results From Kentucky’S 10-Year Bobwhite Recovery Plan, Cody M. Rhoden, John J. Morgan, Ben A. Robinson, Gary Sprandel
Results From Kentucky’S 10-Year Bobwhite Recovery Plan, Cody M. Rhoden, John J. Morgan, Ben A. Robinson, Gary Sprandel
National Quail Symposium Proceedings
The northern bobwhite (Colinus virginianus; hereafter, bobwhite) has experienced a precipitous population decline through almost all its historical range over the last 6 decades. We initiated a 10-year restoration plan in Kentucky, USA in 2008 and reported on it through 3 published “Road to Recovery” reports along with 30 peer-reviewed articles and abstracts, 2 technical documents, 7 theses or dissertations, and 11 popular literature pieces. Seven Quail Focus Areas were selected across the state based on site personnel, geographic position (east to west), and land ownership (e.g., private, public, state, federal) for monitoring and habitat management. The focus …
Lessons Learned From The First 10 Years Of The Oaks And Prairies Joint Venture’S Grassland Restoration Incentive Program (Grip), James J. Giocomo, Robert M. Perez, Kenneth Gee, Steven Riley, Derek Wiley, Anna M. Matthews, Ty Higginbotham, Amanda Haverland, Thomas S. Janke, Amber Brown, Kati Biggs, Mitchell Riggs, Taylor Daily, Charlotte Wilson, Cole Fagen, William Newman, Leah Lowe, Jonathan Hayes
Lessons Learned From The First 10 Years Of The Oaks And Prairies Joint Venture’S Grassland Restoration Incentive Program (Grip), James J. Giocomo, Robert M. Perez, Kenneth Gee, Steven Riley, Derek Wiley, Anna M. Matthews, Ty Higginbotham, Amanda Haverland, Thomas S. Janke, Amber Brown, Kati Biggs, Mitchell Riggs, Taylor Daily, Charlotte Wilson, Cole Fagen, William Newman, Leah Lowe, Jonathan Hayes
National Quail Symposium Proceedings
The Oaks and Prairies Joint Venture (OPJV) was formed in 2008 as a public-private partnership of agencies and organizations working across jurisdictional boundaries in portions of Texas and Oklahoma, USA. The OPJV’s major focus is reversing declines of bird populations by supporting strategic habitat conservation (biological planning, conservation design, conservation delivery, mission-based monitoring, and assumption-driven research) for northern bobwhite (Colinus virginianus), grasslandobligate species, and their respective habitats. Our objective for this paper is to document and share a decade of lessons learned in developing a partnership-based native grassland conservation program to meet grassland bird conservation targets. We share …
Landowner Cooperative Key To Success In The Bee Ridge Quail Focus Area, John A. Pinkowski, Beth A. Emmerich, William T. White
Landowner Cooperative Key To Success In The Bee Ridge Quail Focus Area, John A. Pinkowski, Beth A. Emmerich, William T. White
National Quail Symposium Proceedings
The Missouri Department of Conservation (MDC) began establishing Quail Focus Areas (QFAs) on private lands in 2004. The goal of QFAs is to increase and expand quail habitat management efforts around a core area. Because most (93%) of the landscape of Missouri, USA is in private ownership, habitat improvement programs on private lands have greater potential to impact quail populations than on public lands alone. A motivated group of landowners led the charge to begin habitat improvement efforts in the Bee Ridge QFA. This group was instrumental in starting earlier monitoring efforts to determine whether habitat improvements were leading to …
Habitat Works: How Partnerships And Habitat Improvement Have Restored Quail Populations In The 2c Quail Focus Area, E. Lee Metcalf, Beth A. Emmerich, William T. White
Habitat Works: How Partnerships And Habitat Improvement Have Restored Quail Populations In The 2c Quail Focus Area, E. Lee Metcalf, Beth A. Emmerich, William T. White
National Quail Symposium Proceedings
The Missouri Department of Conservation (MDC) began establishing Quail Focus Areas (QFAs) on private lands in 2004. The goal of QFAs was to bring groups of landowners together to manage bobwhite habitat on a larger scale in a targeted landscape. Through a variety of state, federal, and other partnership programs, habitat improvement efforts have resulted in large increases in northern bobwhite (Colinus virginianus; hereafter, bobwhite) numbers in the 2C QFA. In spring 2013, MDC staff and Quail Forever biologists began monitoring bobwhite and songbirds in a portion of the 2C QFA in Carroll County, Missouri, USA and in …
Adaptive Management Facilitates Increase In Northern Bobwhite Populations, James A. Martin, Clay Sisson, Justin Rectenwald, Paige Howell
Adaptive Management Facilitates Increase In Northern Bobwhite Populations, James A. Martin, Clay Sisson, Justin Rectenwald, Paige Howell
National Quail Symposium Proceedings
Adaptive resource management (ARM) is an approach to managing that allows decision makers to learn about a system and subsequently change management actions based on new information about system processes (i.e., adapt) to better meet fundamental objectives. This is not to be confused with changing management actions when the state of the system changes. For example, changing a harvest regulation when populations decline is not ARM. This dynamic decision making may be fortuitously optimal, but if the effect of harvest is uncertain then changing regulations may be suboptimal—for example, weather may have caused the decline. Adaptive resource management can be …
Northern Bobwhite Demographics And Resource Selection Are Explained By Prescribed Fire With Grazing And Woody Cover In Southwest Missouri, Frank R. Thompson Iii, Mitch D. Weegman, Emily A. Sinnott, Alisha R. Mosloff, Kyle R. Hedges, Frank L. Loncarich, Thomas R. Thompson, Nicholas C. Burrell, Stasia Whitaker, David E. Hoover
Northern Bobwhite Demographics And Resource Selection Are Explained By Prescribed Fire With Grazing And Woody Cover In Southwest Missouri, Frank R. Thompson Iii, Mitch D. Weegman, Emily A. Sinnott, Alisha R. Mosloff, Kyle R. Hedges, Frank L. Loncarich, Thomas R. Thompson, Nicholas C. Burrell, Stasia Whitaker, David E. Hoover
National Quail Symposium Proceedings
Understanding the effects of landscape management on northern bobwhite (Colinus virginianus; hereafter, bobwhite) population growth requires information about seasonal- and stage-specific demographic parameters linked across the annual cycle. We review results to date from 3 years (2016–2018) of an intensive field study evaluating drivers of bobwhite population dynamics and resource selection during the breeding and non-breeding season in southwest Missouri, USA using data from adult and juvenile bobwhite fitted with radio-transmitters. Land cover of our study sites ranged from large blocks of native grasslands maintained with prescribed fire and grazing to more traditional management resulting in small patches …
Adaptive Management And Quail Conservation On Rangelands In The American West, Leonard A. Brennan, Ashley Tanner, Evan P. Tanner
Adaptive Management And Quail Conservation On Rangelands In The American West, Leonard A. Brennan, Ashley Tanner, Evan P. Tanner
National Quail Symposium Proceedings
Adaptive management has been and is being practiced with the goal of sustaining populations of wild quails on large areas of rangelands in the American West. Because the current land use practices throughout most of the eastern two-thirds of the United States largely do not promote early-successional vegetation communities, rangelands contain the largest remaining blocks of contiguous (unfragmented) habitat for the northern bobwhite (Colinus virginianus) and the other 5 species of quails found in the western states. Many wildlife professionals on both private and public rangelands are practicing a diverse array of quail habitat and population management actions …
John And Catherine Pennisi Papers, 1974-2011, John Pennisi, Catherine Pennisi
John And Catherine Pennisi Papers, 1974-2011, John Pennisi, Catherine Pennisi
Center for Restoration Studies Archives, Manuscripts and Personal Papers Finding Aids
No abstract provided.
Interactions Of Marine Sulfated Glycans With Antithrombin And Platelet Factor 4, Wenjing Zhang, Weihua Jin, Vitor H. Pomin, Fuming Zhang
Interactions Of Marine Sulfated Glycans With Antithrombin And Platelet Factor 4, Wenjing Zhang, Weihua Jin, Vitor H. Pomin, Fuming Zhang
Faculty and Student Publications
The molecular interactions of sulfated glycans, such as heparin, with antithrombin (AT) and platelet factor 4 (PF4) are essential for certain biological events such as anticoagulation and heparin induced thrombocytopenia (HIT). In this study, a library including 84 sulfated glycans (polymers and oligomers) extracted from marine algae along with several animal-originated polysaccharides were subjected to a structure-activity relationship (SAR) study regarding their specific molecular interactions with AT and PF4 using surface plasmon resonance. In this SAR study, multiple characteristics were considered including different algal species, different methods of extraction, molecular weight, monosaccharide composition, sulfate content and pattern and branching vs. …
Inhibition Of Sars-Cov-2 Wild-Type (Wuhan-Hu-1) And Delta (B.1.617.2) Strains By Marine Sulfated Glycans, Rohini Dwivedi, Poonam Sharma, Marwa Farrag, Seon Beom Kim
Inhibition Of Sars-Cov-2 Wild-Type (Wuhan-Hu-1) And Delta (B.1.617.2) Strains By Marine Sulfated Glycans, Rohini Dwivedi, Poonam Sharma, Marwa Farrag, Seon Beom Kim
Faculty and Student Publications
The Coronavirus disease pandemic has steered the global therapeutic research efforts toward the discovery of potential anti-severe acute respiratory syndrome coronavirus (SARS-CoV-2) molecules. The role of the viral spike glycoprotein (S-protein) has been clearly established in SARS-CoV-2 infection through its capacity to bind to the host cell surface heparan sulfate proteoglycan (HSPG) and angiotensin-converting enzyme-2. The antiviral strategies targeting these 2 virus receptors are currently under intense investigation. However, the rapid evolution of the SARS-CoV-2 genome has resulted in numerous mutations in the S-protein posing a significant challenge for the design of S-protein-targeted inhibitors. As an example, the 2 key …
Possible Gender Differences In The Level Of Perceived Social Support In Couples Who Are Experiencing Issues With Infertility., Maya Pinzon, Shawna Rotoli
Possible Gender Differences In The Level Of Perceived Social Support In Couples Who Are Experiencing Issues With Infertility., Maya Pinzon, Shawna Rotoli
Rowan-Virtua School of Osteopathic Medicine Departmental Research
Objective The purpose of this study is to examine whether there are gender differences in the level of perceived social support in couples experiencing issues with fertility. Methods A total of 938 participants aged 18-47 years, with self-reported issues of infertility, were evaluated using the Multidimensional Scale of Perceived Social Support (MSPSS) which comprises three subscales which correspond with distinct sources of social support: significant other (SO), family, and friends. Differences between sexes for total score and for all subscale scores were subsequently analyzed using SPSS Statistics (IBM Corp, Armonk, USA). Results Mean total scores and scores on all subscales …
A Digital Leadership Lens For A Physical World: Digital Transformation Levers Of Control For Incumbent Companies, Michael J. Seals
A Digital Leadership Lens For A Physical World: Digital Transformation Levers Of Control For Incumbent Companies, Michael J. Seals
Dissertations
A new wave of advanced technologies is disrupting companies of all types and transforming business models within every industry. Long-standing industrial firms that rose to prominence in a pre-digital economy are particularly vulnerable. Prevailing views suggest these companies (hereafter referred to as incumbents) must reimagine their value propositions and transform themselves by leveraging today’s advanced technologies. The opportunities provided by these advanced technologies will significantly affect incumbents whether they participate or not. The pursuit of these opportunities, commonly referred to as digital transformation (DX), is the focus of our research.
Traditional technology-enabled business endeavors creating incremental operational improvements fell within …
College Of Liberal Arts Faculty Bylaws - Amended 9/19/22, College Of Liberal Arts Faculty, Rollins College
College Of Liberal Arts Faculty Bylaws - Amended 9/19/22, College Of Liberal Arts Faculty, Rollins College
College of Liberal Arts Bylaws
No abstract provided.
Race In The United States: A View From Outer Space, Stephen W. Smith, Géraldine Faes-Smith
Race In The United States: A View From Outer Space, Stephen W. Smith, Géraldine Faes-Smith
Law and Contemporary Problems
No abstract provided.
Molecular Pathways Of Wrky Genes In Regulating Plant Salinity Tolerance, Lewis Price, Yong Han, Tefera Angessa, Chengdao Li
Molecular Pathways Of Wrky Genes In Regulating Plant Salinity Tolerance, Lewis Price, Yong Han, Tefera Angessa, Chengdao Li
Grain and Other Field Crops Research Articles
Salinity is a natural and anthropogenic process that plants overcome using various responses. Salinity imposes a two-phase effect, simplified into the initial osmotic challenges and subsequent salinity-specific ion toxicities from continual exposure to sodium and chloride ions. Plant responses to salinity encompass a complex gene network involving osmotic balance, ion transport, antioxidant response, and hormone signalling pathways typically mediated by transcription factors. One particular transcription factor mega family, WRKY, is a principal regulator of salinity responses. Here, we categorize a collection of known salinity-responding WRKYs and summarize their molecular pathways. WRKYs collectively play a part in regulating osmotic balance, ion …
Intouch September 19, 2022, New York Medical College
Intouch September 19, 2022, New York Medical College
InTouch
- NYMC and TU Host Successful Innovation and Entrepreneurship Conference
- School of Medicine Launches New Medical Education Curriculum
- The Inaugural Dr. Melvin H. Amler Prize for Innovation to be Announced
- Annual Club Fair Boasts Record Number of Student Organizations
- NYMC Goes Gold for Childhood Cancer
- Rajkumar Pammal, SOM Class of 2023, Hopes to Be an Agent of Change in Emergency Medicine
The Rider (2022-09-19), Verilu Infante
Progress In Food Safety Rapid Analysis Based On Deoxyribozyme, Zeng Yu, Chen Wei-Ju, Quan Ke, Lei Yan-Li
Progress In Food Safety Rapid Analysis Based On Deoxyribozyme, Zeng Yu, Chen Wei-Ju, Quan Ke, Lei Yan-Li
Food and Machinery
The article expounds the structure and activity of DNAzyme, and reviews the application progress of DNAzymes in the detection of heavy metal ions, pathogenic bacteria, microbial toxin and other illegal chemical components in food. The challenges faced by DNAzymes in the actual detection of food harmful substances are analyzed and summarized, and future development prospect in rapid and on-site detection are prospected.
Chimes: September 19, 2022, Calvin University
Chimes: September 19, 2022, Calvin University
Chimes
Calvin to invest in goals of Strategic Plan for Athletics, including possible football team by Lauren Nyong
Between grief and hope: Social work at Calvin a program in recovery by Katie Rosendale
With no COVID restrictions, campus navigates new normal by Grace Buller
Remote job opportunities come with benefits and drawbacks for students and alumni by Ezra Cracker
Rhetoric Center reaches across campus with resources for all disciplines by Emily Thomas
Engineering professor aims to start conversations about gender diversity in make-dominated field with new book by David Ogboro
Behind the screens: a graduate student's journey from band director to …
Interdisciplinary Approaches And Strategies From Research Reproducibility 2020: Educating For Reproducibility, Melissa L. Rethlefsen, Hannah F. Norton, Sarah L. Meyer, Katherine A. Macwilkinson, Plato L. Smith Ii, Hao Ye
Interdisciplinary Approaches And Strategies From Research Reproducibility 2020: Educating For Reproducibility, Melissa L. Rethlefsen, Hannah F. Norton, Sarah L. Meyer, Katherine A. Macwilkinson, Plato L. Smith Ii, Hao Ye
Publications
Research Reproducibility: Educating for Reproducibility, Pathways to Research Integrity was an interdisciplinary, conference hosted virtually by the University of Florida in December 2020. This event brought together educators, researchers, students, policy makers, and industry representatives from across the globe to explore best practices, innovations, and new ideas for education around reproducibility and replicability. Emphasizing a broad view of rigor and reproducibility, the conference touched on many aspects of introducing learners to transparency, rigorous study design, data science, data management, replications, and more. Transdisciplinary themes emerged from the panels, keynote, and submitted papers and poster presentations. The identified themes included lifelong …
Application Of The Weibull Model To Describe The Kinetic Behaviors Of Thiol Decolorizers In Chlorogenic Acid-Lysine Solutions, Charles Taylor Drucker, Lilian Were Senger, Criselda Toto Pacioles
Application Of The Weibull Model To Describe The Kinetic Behaviors Of Thiol Decolorizers In Chlorogenic Acid-Lysine Solutions, Charles Taylor Drucker, Lilian Were Senger, Criselda Toto Pacioles
Food Science Faculty Articles and Research
Thiols (cysteine and glutathione) were explored as potential decolorization agents to mitigate green pigment formation in chlorogenic acid quinone-lysine solutions. Reparameterizations of the Weibull cumulative distribution function were applied to describe the time-dependence of greening under varying pH conditions. Repeated fitting of 3-parameter models (RMSE = 0.0111, CVRMSE = 1.55%) indicated the linear dependence of model parameters on thiol concentration. A 6-parameter Weibull model incorporating time and initial thiol concentration (RMSE = 0.0255, CVRMSE = 3.56%) accurately predicted green color development. Calculated model parameters descriptive of greening rate, terminal greening magnitude, and lag time before greening onset facilitated comparison of …
Integrated Stem Cell Signature And Cytomolecular Risk Determination In Pediatric Acute Myeloid Leukemia., Benjamin J. Huang, Jenny L. Smith, Jason E. Farrar, Yi-Cheng Wang, Masayuki Umeda, Rhonda E. Ries, Amanda R. Leonti, Erin Crowgey, Scott N. Furlan, Katherine Tarlock, Marcos Armendariz, Yanling Liu, Timothy I. Shaw, Lisa Wei, Robert B. Gerbing, Todd M. Cooper, Alan S. Gamis, Richard Aplenc, E Anders Kolb, Jeffrey Rubnitz, Jing Ma, Jeffery M. Klco, Xiaotu Ma, Todd A. Alonzo, Timothy Triche, Soheil Meshinchi
Integrated Stem Cell Signature And Cytomolecular Risk Determination In Pediatric Acute Myeloid Leukemia., Benjamin J. Huang, Jenny L. Smith, Jason E. Farrar, Yi-Cheng Wang, Masayuki Umeda, Rhonda E. Ries, Amanda R. Leonti, Erin Crowgey, Scott N. Furlan, Katherine Tarlock, Marcos Armendariz, Yanling Liu, Timothy I. Shaw, Lisa Wei, Robert B. Gerbing, Todd M. Cooper, Alan S. Gamis, Richard Aplenc, E Anders Kolb, Jeffrey Rubnitz, Jing Ma, Jeffery M. Klco, Xiaotu Ma, Todd A. Alonzo, Timothy Triche, Soheil Meshinchi
Manuscripts, Articles, Book Chapters and Other Papers
Relapsed or refractory pediatric acute myeloid leukemia (AML) is associated with poor outcomes and relapse risk prediction approaches have not changed significantly in decades. To build a robust transcriptional risk prediction model for pediatric AML, we perform RNA-sequencing on 1503 primary diagnostic samples. While a 17 gene leukemia stem cell signature (LSC17) is predictive in our aggregated pediatric study population, LSC17 is no longer predictive within established cytogenetic and molecular (cytomolecular) risk groups. Therefore, we identify distinct LSC signatures on the basis of AML cytomolecular subtypes (LSC47) that were more predictive than LSC17. Based on these findings, we build a …