Digital Commons Network^™

Prognostic Molecular Biomarkers In Chordomas: A Systematic Review And Identification Of Clinically Usable Biomarker Panels, Franco Rubino, Christopher Alvarez-Breckenridge, Kadir Akdemir, Anthony P Conley, Andrew J Bishop, Wei-Lien Wang, Alexander J Lazar, Laurence D Rhines, Franco Demonte, Shaan M Raza

Faculty, Staff and Student Publications

INTRODUCTION AND OBJECTIVE: Despite the improvements in management and treatment of chordomas over time, the risk of disease recurrence remains high. Consequently, there is a push to develop effective systemic therapeutics for newly diagnosed and recurrent disease. In order to tailor treatment for individual chordoma patients and develop effective surveillance strategies, suitable clinical biomarkers need to be identified. The objective of this study was to systematically review all prognostic biomarkers for chordomas reported to date in order to classify them according to localization, study design and statistical analysis.

METHODS: Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) …

The Montclarion, September 29, 2022, The Montclarion

The Montclarion

Student Newspaper of Montclair State University

The Cowl - V. 87 N. 3 - September 29, 2022

The Cowl

The Cowl - student newspaper of Providence College. Vol. 87 No. 3 - September 29, 2022. 20 pages.

Small Molecule Modulation Of Microbiota: A Systems Pharmacology Perspective, Qiao Liu, Bohyun Lee, Lei Xie

Publications and Research

Background

Microbes are associated with many human diseases and influence drug efficacy. Small-molecule drugs may revolutionize biomedicine by fine-tuning the microbiota on the basis of individual patient microbiome signatures. However, emerging endeavors in small-molecule microbiome drug discovery continue to follow a conventional “one-drug-one-target-one-disease” process. A systematic pharmacology approach that would suppress multiple interacting pathogenic species in the microbiome, could offer an attractive alternative solution.

Results

We construct a disease-centric signed microbe–microbe interaction network using curated microbe metabolite information and their effects on host. We develop a Signed Random Walk with Restart algorithm for the accurate prediction of effect of microbes …

Mucus-Degrading Bacteroides Link Carbapenems To Aggravated Graft-Versus-Host Disease, Eiko Hayase, Tomo Hayase, Mohamed A Jamal, Takahiko Miyama, Chia-Chi Chang, Miriam R Ortega, Saira S Ahmed, Jennifer L Karmouch, Christopher A Sanchez, Alexandria N Brown, Rawan K El-Himri, Ivonne I Flores, Lauren K Mcdaniel, Dung Pham, Taylor Halsey, Annette C Frenk, Valerie A Chapa, Brooke E Heckel, Yimei Jin, Wen-Bin Tsai, Rishika Prasad, Lin Tan, Lucas Veillon, Nadim J Ajami, Jennifer A Wargo, Jessica Galloway-Peña, Samuel Shelburne, Roy F Chemaly, Lauren Davey, Robert W P Glowacki, Chen Liu, Gabriela Rondon, Amin M Alousi, Jeffrey J Molldrem, Richard E Champlin, Elizabeth J Shpall, Raphael H Valdivia, Eric C Martens, Philip L Lorenzi, Robert R Jenq

Faculty, Staff and Student Publications

The intestinal microbiota is an important modulator of graft-versus-host disease (GVHD), which often complicates allogeneic hematopoietic stem cell transplantation (allo-HSCT). Broad-spectrum antibiotics such as carbapenems increase the risk for intestinal GVHD, but mechanisms are not well understood. In this study, we found that treatment with meropenem, a commonly used carbapenem, aggravates colonic GVHD in mice via the expansion of Bacteroides thetaiotaomicron (BT). BT has a broad ability to degrade dietary polysaccharides and host mucin glycans. BT in meropenem-treated allogeneic mice demonstrated upregulated expression of enzymes involved in the degradation of mucin glycans. These mice also had thinning of the colonic …

Using A Literature Based Discovery Approach To Study Moderating Effects And Preventive Mechanisms Of Online Game Addiction Problems Among Gamers, Ananya Sinha Choudhury

Lingnan Theses (MPhil & PhD)

This research makes use of a hypothesis generation technique known as Literature-Based Discovery (LBD) to study certain under-researched topics related to online game addiction problems in our society. This research work tries to primarily address two problems related to game addiction which have been under-studied according to the literature available on this topic. In the first problem, we try to identify certain moderating factors of massively multiplayer games which weakens the relationship between the psychological flow state and game addiction. In this data-driven approach, we studied 2829 abstracts to generate a list of keywords that suggest potential moderating factors for …

Testing A Behavioral Activation Gaming App For Depression During Pregnancy: Multimethod Pilot Study, Philipp Karschnia, Jacob S Young, Antonio Dono, Levin Häni, Stephanie T Juenger, Tommaso Sciortino, Francesco Bruno, Nico Teske, Ramin A Morshed, Alexander F Haddad, Yalan Zhang, Sophia Stoecklein, Michael A Vogelbaum, Juergen Beck, Nitin Tandon, Shawn Hervey-Jumper, Annette M Molinaro, Roberta Rudà, Lorenzo Bello, Oliver Schnell, Yoshua Esquenazi, Maximilian I Ruge, Stefan J Grau, Martin Van Den Bent, Michael Weller, Mitchel S Berger, Susan M Chang, Joerg-Christian Tonn

Faculty, Staff and Student Publications

In IDH-wildtype glioblastomas which meet the histopathological or molecular diagnosis criteria, it remains unclear whether the presence of TERT promotor mutations provides additional prognostic information. Based on a multicenter cohort of 466 IDH-wildtype glioblastomas (including 396 with and 70 patients without TERT promotor mutations), we found that TERT promotor mutations were neither associated with progression-free survival nor overall survival. This held true in various treatment-based or molecular subgroups. This argues against standardized analysis for TERT promotor mutation status for the purpose of prognostic or therapeutic relevance in newly diagnosed IDH-wildtype glioblastoma that otherwise meets the histopathological and …

Reconstructing Sedimentary Processes In A Permian Channel–Lobe Transition Zone: An Outcrop Study In The Karoo Basin, South Africa, F Pohl, Jt Eggenhuisen, J De Leeuw, Et Al

School of Biological and Marine Sciences

Turbidity currents commonly bypass sediment in submarine channels on the continental slope, and deposit sediment lobes farther down-dip on the flat and unconfined abyssal plain. Seafloor and outcrop data have shown that the transition from bypass to deposition usually occurs over complex zones referred to as channel–lobe transition zones (CLTZs). Recognition of these zones in cores and outcrop remains challenging due to a lack of characteristic sedimentary facies and structures. This paper focuses on Unit E of the Permian Fort Brown Formation in the Karoo Basin, South Africa, in the Slagtersfontein outcrop complex, which has previously been interpreted as a …

De Novo Variants In Emc1 Lead To Neurodevelopmental Delay And Cerebellar Degeneration And Affect Glial Function In Drosophila, Hyung-Lok Chung, Patrick Rump, Di Lu, Megan R Glassford, Jung-Wan Mok, Jawid Fatih, Adily Basal, Paul C Marcogliese, Oguz Kanca, Michele Rapp, Johanna M Fock, Erik-Jan Kamsteeg, James R Lupski, Austin Larson, Mark C Haninbal, Hugo Bellen, Tamar Harel

Duncan NRI Faculty and Staff Publications

Background: The endoplasmic reticulum (ER)-membrane protein complex (EMC) is a multi-protein transmembrane complex composed of 10 subunits that functions as a membrane-protein chaperone. Variants in EMC1 lead to neurodevelopmental delay and cerebellar degeneration. Multiple families with biallelic variants have been published, yet to date, only a single report of a monoallelic variant has been described, and functional evidence is sparse.

Methods: Exome sequencing was used to investigate the genetic cause underlying severe developmental delay in three unrelated children. EMC1 variants were modeled in Drosophila, using loss-of-function (LoF) and overexpression studies. Glial-specific and neuronal-specific assays were used to determine whether the …

Kenyon Collegian - September 29, 2022

The Kenyon Collegian

No abstract provided.

Cascon 2022, College Of Arts & Sciences

SHU Faculty Publications

CASCon showcases the work of Sacred Heart University faculty from multiple disciplines. The conference emphasizes the interdisciplinary nature of faculty scholarship and reaffirms the College’s commitment to undergraduate research.

6th Annual College of Arts & Sciences Conference (CASCon) on Wednesday, September 28, 2022.

First Annual Pasqueflower Undergraduate Research Award With The Native Plant Initiative, Native Plant Initiative

Native Plant Initiative Newsletters and Reports

Information on the First Annual Pasqueflower Undergraduate Research Award with the Native Plant Initiative

Senate Meeting, September 28, 2022, Academic Senate

Academic Senate Minutes

No abstract provided.

David Webb V. City Of Wilmington

2022 Decisions

USDC for the District of Delaware

Faculty Senate Agenda, October 3, 2022, Utah State University

Faculty Senate & Faculty Senate Executive Committee

• Call to Order
• University Business
• Information
• Educational Policies Committee - September 1, 2022
• Reports
• Educational Policies Committee Annual Report
• Empower Teaching Excellence Annual Report
• Old Business
• Code 401 Track Changes | Clean Version
• New Business
• Brief Overview of Senate Responsibilities | Orientation
• Adjourn: 4:30

Volume 4 (2022) Proceedings Of The 2022 Undergraduate Research Day, Rebecca Day Babcock Dr., Mohamed Zobaa

UTPB Student Research Day 2026

No abstract provided.

Kidney Resident Macrophages Have Distinct Subpopulations And Occupy Distinct Microenvironments, Jeff Hansen

Browse All News

No abstract provided.

Undergraduate Student Publishes Sleep Research Paper, Erin Garrett

University of Mississippi News

UM senior studies correlation between brain anatomy and sleep duration

Toward Mental Effort Measurement Using Electrodermal Activity Features, William Romine, Noah Schroeder, Tanvi Banerjee, Josephine Graft

Computer Science and Engineering Faculty Publications

The ability to monitor mental effort during a task using a wearable sensor may improve productivity for both work and study. The use of the electrodermal activity (EDA) signal for tracking mental effort is an emerging area of research. Through analysis of over 92 h of data collected with the Empatica E4 on a single participant across 91 different activities, we report on the efficacy of using EDA features getting at signal intensity, signal dispersion, and peak intensity for prediction of the participant's self-reported mental effort. We implemented the logistic regression algorithm as an interpretable machine learning approach and found …

Statistical Modeling And Optimization Of Process Parameters For 2, 4-Dichlorophenoxyacetic Acid Removal By Using Ac/Pdmaema Hydrogel Adsorbent: Comparison Of Different Rsm Designs And Ann Training Methods, Irvan Dahlan, Emilia Eizleen Md Azhar, Siti Roshayu Hassan, Hamidi Abdul Aziz, Yung-Tse Hung

Civil and Environmental Engineering Faculty Publications

In this study, the response surface methodology (RSM) and artificial neural network (ANN) were employed to study the adsorption process of 2,4-dichlorophenoxyacetic acid (2,4-D) by using modified hydrogel, i.e., activated carbon poly(dimethylaminoethyl methacrylate) (AC/PDMAEMA hydrogel). The effect of pH, the initial concentration of 2,4-D and the activated carbon content on the removal of 2,4-D and adsorption capacity were investigated through the face-centered composite design (FCCD), optimal design and two-level factorial design. The response surface plot suggested that higher removal of 2,4-D and adsorption capacity could be achieved at the higher initial concentration of 2,4-D and lower pH and activated carbon …

University Band & Philharmonic Orchestra

Bailey School of Music Concert Programs

Performance by the University Band & Philmarnoc

The Lumberjack, September 28, 2022

Cal Poly Humboldt's Student Newspaper

The student newspaper of Humboldt State University.

Mteds: Multivariant Time Series-Based Encoder-Decoder System For Anomaly Detection, A. Reyana, Sandeep Kautish, I. S. Yahia, Ali Wagdy Mohamed

Faculty Journal Articles

Intrusion detection systems examine the computer or network for potential security vulnerabilities. Time series data is real-valued. The nature of the data influences the type of anomaly detection. As a result, network anomalies are operations that deviate from the norm. These anomalies can cause a wide range of device malfunctions, overloads, and network intrusions. As a result of this, the network's normal operation and services will be disrupted. The paper proposes a new multi-variant time series-based encoder-decoder system for dealing with anomalies in time series data with multiple variables. As a result, to update network weights via backpropagation, a radical …

Recent Development Of Low Iridium Electrocatalysts Toward Efficient Water Oxidation, Jing Ni, Zhao-Ping Shi, Xian Wang, Yi-Bo Wang, Hong-Xiang Wu, Chang-Peng Liu, Jun-Jie Ge, Wei Xing

Journal of Electrochemistry

Developing high-performance and low-cost electrocatalysts for oxygen evolution reaction (OER) is the key to implementing polymer electrolyte membrane water electrolyzer (PEMWE) for hydrogen production. To date, iridium (Ir) is the state-of-the-art OER catalyst, but still suffers from the insufficient activity and scarce earth abundance, which results in high cost both in stack and electricity. Design low-Ir catalysts with enhanced activity and stability that can match the requirements of high current and long-term operation in PEMWE is thus highly desired, which necessitate a deep understanding of acidic OER mechanisms, unique insights of material design strategies, and reliable performance evaluation norm, especially …

Biogeochemical Responses To Mixing Of Glacial Meltwater And Hot Spring Discharge In The Mount St. Helens Crater, Ashley Dubnick, Q. Faber, J. R. Hawkings, N. Bramall, B. C. Christner, Peter T. Doran, Jay Nadeau, C. Snyder, Multiple Additional Authors

Physics Faculty Publications and Presentations

Environments where geothermal waters and glacier meltwater mix are common on Earth yet little is known about the biogeochemical processes that occur when hot, reduced geothermal water mixes with cold, oxidized glacial meltwater in natural systems. Mount St. Helens provides an ideal location to study the interaction between geothermal and glacier waters since the water sources, and their mixing environment in Step Creek, are exposed in the volcanic crater. We find that the two water sources contain distinct major ion, trace element, dissolved organic matter (DOM), and biological signatures. The hot spring contains high concentrations of biogeochemically reactive components (e.g., …

A Case Of Persistent Human Pegivirus Infection In Two Separate Pregnancies Of A Woman, Mathieu Garand, Susie S Y Huang, Lisa S Goessling, Donna A Santillan, Mark K Santillan, Anoop Brar, Todd N Wylie, Kristine M Wylie, Pirooz Eghtesady

2020-Current year OA Pubs

Human pegivirus (HPgV) is best known for persistent, presumably non-pathogenic, infection and a propensity to co-infect with human immunodeficiency virus or hepatitis C virus. However, unique attributes, such as the increased risk of malignancy or immune modulation, have been recently recognized for HPgV. We have identified a unique case of a woman with high levels HPgV infection in two pregnancies, which occurred 4 years apart and without evidence of human immunodeficiency virus or hepatitis C virus infection. The second pregnancy was complicated by congenital heart disease. A high level of HPgV infection was detected in the maternal blood from different …

Editorial: Function And Formation Of Mitochondrial Metalloproteome, Michał Wasilewski, Vishal M. Gohil, Oleh Khalimonchuk

Department of Biochemistry: Faculty Publications

No abstract provided.

Effects Of Early‑Life Experience On Innovation And Problem‑Solving In Captive Coyotes, Andrew C. Garcia, Mitchell A. Parsons, Julie K. Young

United States Department of Agriculture Wildlife Services: Staff Publications

Early-life experience often shapes behaviors like innovation and exploration. These behaviors are important to animals encountering novel food resources in diverse habitats, such as mesocarnivores in urban areas. To understand if early-life experiences impact later-life behavior, we examined how coyotes (Canis latrans) responded to a multi-access puzzle box at two life stages: pup (~ 7 weeks) and dispersal (~ 10 months). We first exposed pups, still living with their parents and littermates, to a baited puzzle box. At dispersal age, we again tested both these pups and an age-matched control group that was not exposed to the puzzle …

Data Supporting A Saturation Mutagenesis Assay For Tat-Driven Transcription With The Gigaassay, Ronald Benjamin, Christopher J. Giacoletto, Zachary T. Fitzhugh, Danielle Eames, Lindsay Buczek, Xiaogang Wu, Jacklyn Newsome, Mira V. Han, Tony Pearson, Zhi Wei, Atoshi Banerjee, Lancer Brown, Liz J. Valente, Shirley Shen, Hong-Wen Deng, Martin R. Schiller

Life Sciences Faculty Research

The data in this article are associated with the research paper “GigaAssay – an adaptable high-throughput saturation mutagenesis assay". The raw data are sequence reads of HIV-1 Tat cDNA amplified from cellular genomic DNA in a new single-pot saturation mutagenesis assay designated the “GigaAssay”. A bioinformatic pipeline and parameters used to analyze the data. Raw, processed, analyzed, and filtered data are reported. The data is processed to calculate the Tat-driven transcription activity for cells with each possible single amino acid substitution in Tat. This data can be reused to interpret Tat intermolecular interactions and HIV latency. This is one of …

Identification Of Serum Anti-Carbamylated Protein Antibodies In Rheumatoid Arthritis Patients With Periodontitis: A Pilot Study, Shruthi Venu Gopal

Student Works (2020-2029)

Objectives: In chronic diseases such as rheumatoid arthritis (RA), carbamylation may cause the production of autoantibodies such as the anti-carbamylated protein antibody (anti-CarP) and protein malfunctioning. However, its relation to periodontitis (PD) remains unclear. Therefore, this study aimed to assess the serum levels of anti-carbamylated protein antibodies (anti-CarP) in four groups of participants, the RAPD, RA, PD, and healthy groups and correlate the findings with rheumatological parameters. Materials and methods: This pilot study included a total of 20 participants, with 5 participants each in groups diagnosed with RA and PD (RAPD), only RA, only PD and controls who were free …