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Evaluation Of Antibacterial Potential Of Artemisinin Extracts Of Artemisia Annua In Vivo And In Vitro, Arsalan Khan, Akhtar Ali, Imtiaz Ali Shah, Umm-E- Aimen, Waseem Ullah, Imtiaz Khan

Journal of Bioresource Management

To ensure universal health care, the World Health Organization recognized the significance of complementary and alternative medicines (CAM) and recommended the use of natural herbs and plants bearing therapeutic potential and fewer adverse effects. Therefore, Artemisia annua herb was evaluated for its antibacterial potential and therapeutic efficacy against Staphylococcus aureus, Streptococcus and Escherichia coli both in vitro and in vivo. Artemisinin was extracted from Artemisia annua by chemical treatment. Subsequently, the culture sensitivity tests were performed on MHA by disk diffusion method to determine the antibacterial potential of the Artemisinin extracts against the test bacteria (in vitro phase). …

Formation And Interrogation Of A Modeling Excel Database For Sorbent Preconcentrate With Gc/Ms, Lisa Caravello

Chemical and Biological Engineering ETDs

Volatile organic compounds (VOCs) are of great interest and the subject of much research, as they can be used in various applications. Preconcentrating this class of analytes is necessary as they can be elusive with simple sampling techniques. VOCs are often captured using sorbents in thermal desorption tubes as preconcentrates prior to analysis, commonly gas chromatography mass spectroscopy (GCMS). There are gaps in knowledge in behavior of materials used as sorbents i.e., if they will retain an analyte of interest appropriately. In this research I seek to eliminate speculation and unknown variables of analyte and sorbent combinations by creating a …

Inheritance Of 2,4‑Dichlorophenoxyacetic Acid (2,4‑D) Resistance In Amaranthus Palmeri, Chandrima Shyam, Dallas E. Peterson, Amit J. Jhala, Mithila Jugulam

Department of Agronomy and Horticulture: Faculty Publications

In this study, the inheritance of 2,4-D resistance in a multiple herbicide-resistant Palmer amaranth (KCTR) was investigated. Direct and reciprocal crosses were performed using 2,4-D-resistant KCTR and susceptible KSS plants to generate F₁ progenies. 2,4-D dose–response assays were conducted to evaluate the response of progenies from each F₁ family along with KCTR and KSS plants in controlled environmental growth chambers. Additionally, 2,4-D-resistant male and female plants from each of the F₁ families were used in pairwise crosses to generate pseudo-F₂ families. Segregation (resistance or susceptibility) of progenies from the F₂ families in response to a …

Medicinal Bismuth: Bismuth-Organic Frameworks As Pharmaceutically Privileged Compounds, Shaila A. Shetu, Luis M. Sanchez-Palestino, Gildardo Rivera-Sanchez, Debasish Bandyopadhyay

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

Historically organometallic compounds have been used to cure certain diseases with limited applications. Although bismuth belongs to the category of heavy metals, many of its derivatives have found applications in modern drug discovery research, mainly because of its low toxicity and higher bioavailability. Being an eco-friendly mild Lewis acid, compounds having bismuth as a central atom are capable of binding several proteins in humans and other species. Bismuth complexes demonstrated antibacterial potential in syphilis, diarrhea, gastritis, and colitis. Apart from antibacterial activities, bismuth compounds exhibited anticancer, antileishmanial, and some extent of antifungal and other medicinal properties. This article discusses major …

Research Infrastructure Core Facilities At Research Centers In Minority Institutions: Part I-Research Resources Management, Operation, And Best Practices, Paul B Tchounwou, Mohamad Malouhi, Elizabeth O Ofili, Emma Fernández-Repollet, Daniel F Sarpong, Richard Yanagihara, Renato J Aguilera, Cecilia Ayón, Xiaoxin Chen, Asok Dasmahapatra, Song Gao, Cimona V Hinton, Robert Holt, Vladimir Kolesnichenko, Michael D Powell, Fatima Merchant, Kinfe K Redda, Abiel Roche-Lima, Cecilia M Shikuma, Jacqueline J Stevens, Jose A Torres, Robert T Trotter, James Wachira, Paul Wang, Kristen J Wells, Jason White, Yanyuan Wu

Faculty, Staff and Student Publications

Funded by the National Institutes of Health (NIH), the Research Centers in Minority Institutions (RCMI) Program fosters the development and implementation of innovative research aimed at improving minority health and reducing or eliminating health disparities. Currently, there are 21 RCMI Specialized (U54) Centers that share the same framework, comprising four required core components, namely the Administrative, Research Infrastructure, Investigator Development, and Community Engagement Cores. The Research Infrastructure Core (RIC) is fundamentally important for biomedical and health disparities research as a critical function domain. This paper aims to assess the research resources and services provided and evaluate the best practices in …

Sequencing An Inserted Concatemer In Caenorhabditis Elegans Strain Hlh-29::Gfp, Simon T. Anderson

Senior Honors Projects, 2020-current

Hairy/Enhancer of Split (HES) proteins and their homologs play vital roles in the development of animals, and in the regulation of cancer and other diseases. HLH-29 is an REF-1 family protein and a Caenorhabditis elegans homolog of human HES proteins. A transgenic animal model has been developed to facilitate analyses of this protein, containing an inserted concatemer of the green fluorescent protein reporter gene, regulated by the hlh-29 promoter, and a mutant rol-6 allele. Though the strain has been used previously, the location and structure of the insertion has been unknown. Sequencing of the whole hlh-29::gfp genome with high-molecular weight …

Comparison Of Arctic Alaska Historical Snow Data With Satellite-Derived Benchmarks And Model Results Using Ilamb Software, Mary Szatkowski

Engineering

Understanding and modeling the permafrost system, hydrologic cycle, energy balance, and biologic systems in the Arctic are dependent, in part, on snow depth and snow distribution. Point-source snow measurements provide ground-truth observations of snow depth and snow water equivalent, although these measurements may be limited in their spatial and temporal distributions. Satellite-derived remote sensing products and gridded model output provide spatial coverage of snow properties, but their applicability is affected by their balance of resolution, computational speed, and accuracy confidence. The goal of this research is to assess the performance of three snow data products derived from remote sensing techniques …

Spatio-Temporal Variation Of Some Physico-Chemical Parameters Of Water In Lower Seybouse River (Northeastern Algeria), Adem Fraga, Amel Ketif, Karima Sifi, Aziz Laifa

Journal of Bioresource Management

Oued Seybouse is one of the most important rivers in Algeria. It runs for about 240 km, flows through sevenwilayas (Guelma, Annaba, Souk Ahras, El Tarf, Oum El Bouaghi, Constantine and Skikda) and 68 municipalities, 30 of which are fully included in its basin, and only partially for the others. OuedSeybouse’s water is exposed to multiple sources of pollution, as it directly receives industrial and urban discharges throughout its course. Also agriculture, which is intensively practiced in the lower valley of Seybouse, contributes to the pollution of this watercourse. In this context, we set out to assess the physical-chemical quality …

Length-Weight Relationships Of The Bream Abramis Brama (Linnaeus, 1758) In Beni- Haroun Dam Of Mila City (North-East Of Algeria), Tolba Mounia, Hadjab Ramzi, Chikara Bouziani Mohamed, Berrouk Houda, Kaouachi Nouha

Journal of Bioresource Management

The study of fish growth is a valuable tool in providing good understanding on the general biology and growth of fish populations, in addition to the comparison of the same fish species populations living in remote geographic areas. Thus, the present work was designed to study the age and growth of Abramis brama species newly introduced in Beni-Haroun dam (Mila department, Northeast Algeria). Here, the study was conducted on sampling of 141 individuals from July 2015 to October 2016. The age of fishes was determined according to scalimetric method, since the fish sex was determined by macroscopic method, showing that …

Selection Strategy Of Small Mammalian Preys By The Common Genet Genetta Genetta Between Natural And Anthropized Environments In Edough Forest Massif (Northeastern Algeria), Fatma Belbel, Mehdi Boukheroufa, Camelia Hesni Benotmane, Rym Sakraoui, Lina Rania Ikram Henada, Feriel Sakraoui

Journal of Bioresource Management

We analyzed fluctuations in of small mammals’ biodiversity through the winter diet of the common genet Genetta genetta (Linnaeus, 1958), to deduce the predator - adopted strategy according to the habitat conditions in which it occurs, particularly in anthropogenic environments. The field sampling was conducted during the 2020 winter season, in two contrasting environments of the Edough mountain range: natural site (Ain Boukal), and anthropized site (Bouzizi landfill). The analysis of 30 collected excrements in each of the two sites, allowed us to identify different food categories including small mammals. The result shows that the common genet is an excellent …

Phytoplankton Community Of Boalia Khal Tributary Of The Halda River, Chattogram, Bangladesh, Md. Shafiqul Islam, M.A. Azadi, Munira Nasiruddin

Journal of Bioresource Management

Boalia Khal is one of the important tributaries of the River Halda. The productivity of the Boalia Khal tributary of the Halda River mainly depends on the phytoplankton diversity. A study was conducted for two years period from January 2017 to December 2018 to identify the phytoplankton community of the Boalia Khal tributary. A total of 61 species of phytoplankton under 37 genera belonging to 8 classes were recorded. The dominant group of phytoplankton was 25 species of Diatoms (40.98 %) followed by 18 species of Green Algae (29.5 %), 9 species of Euglenophytes (14.75 %), 7 species of Blue …

Eutectic Mixtures: A Promising Solvent In Drug Delivery System, Abulfadhel Jaber Neamah, Asmaa M. Rashid, Mowafaq M. Ghareeb

Maaen Journal for Medical Sciences

Eutectic systems, including eutectic salts, deep eutectic solvents, and eutectic molecular mixtures, have recently been shown to have enormous potential in a number of technological and scientific endeavors. Eutectic mixtures, along with other binary systems including solid dispersion, cocrystals, and inclusion complexes, could be used simultaneously to improve a number of drugs, including stability, permeability, and dissolution. Over the past few years, their usefulness in the pharmaceutical field has expanded. On a laboratory scale and an industrial scale, eutectics could be produced quite readily (and occasionally spontaneously). In order to fully utilize eutectics in the pharmaceutical industry, it is essential …

Bright Days Ahead, Editorial Board

Spora: A Journal of Biomathematics

No abstract provided.

A Growing Enquiry – Art & Agriculture, Reconciling Values, Zaena Sheehan

European Journal of Food Drink and Society

No abstract provided.

The Enigma Of Goldberry: Tolkien’S Narrative Braiding Of Genre- And Symbol-Related Vocabularies In The Withywindle River-Daughter, Derek Simon

Journal of Tolkien Research

The enigma of Goldberry continues to stimulate diverse readings of her narrative in the Withywindle Cottage episode. The root contention of this article is that Goldberry’s enigma is textured through Tolkien’s complex narrative braiding of multiple genre- and symbol-specific vocabularies woven together throughout her episode. The effort to interpret the enigma of Goldberry needs to be grounded in the philological, lexical, and thematic signifiers circulating in her storyline. These mythopoeic signifiers are variously conveyed by the genre- and symbol-related vocabularies influencing her enigma in the narrative. Where much of the critical commentary has justifiably considered a single strand of source …

Morphological And Anatomical Characterization Of Cymbopogon Citratus (Dc.) Stapf Cultivated In Egypt, Yasmine F. Madi, Meselhy R. Meselhy, El-Sayeda A. El-Kashoury, Mouchira A. Choucry

Bulletin of Faculty of Pharmacy Cairo University

Cymbopogon citratus (DC.) Stapf (family Poaceae) is a tropical lemon-scented perennial grass commonly used, fresh or dried, in food and herbal teas. This study revealed that C. citratus different organs are characterized by histological features distinctive to family Poaceae. Characteristic oil cells stained pink with Schiff′s reagent were noticed particularly in the leaf and culm. Scattered closed-type vascular bundles are observed in different organs. Graminaceous stomata and phytolith are restricted to the leaf blade, leaf sheath, and culm. C. citratus leaf is featured by its remarkable epidermal structure formed of long and short cells, bulliform cells, bundle sheath cells, as …

Menstrual Knowledge And Biosocial Aspects Among The Poumai Adolescents Of Manipur, Northeast India, P.S. Vaveine Pao, S. Yaiphaba Meitei

International Journal of Health and Allied Sciences

BACKGROUND Menstrual knowledge, hygiene, and perception are often neglected worldwide, especially in smaller and less developed societies, exposing adolescents to menstrual health hazards. Against the poor communication of menstrual health and hygiene, the present paper attempts to assess the attitude, knowledge, and perceptions towards menstruation among Poumai adolescents of Manipur, Northeast India. METHODS It is a cross-sectional study with data collected from 491 Poumai adolescents through a cross-sectional study using a self-structured schedule on menstrual knowledge. RESULTS The mean age of the respondents was 17.11±1.33 years. 73.12% of adolescents did not know about menstruation before attaining menarche. Most of the …

Nutrient Adequacy Among Pregnant Women With Altered Iodine Status, Syeda Farha, Asna Urooj

International Journal of Health and Allied Sciences

Background: Pregnant women, are one of the most vulnerable groups for iodine deficiency. Alteration in the nutritional status during pregnancy can have a significant impact on maternofoetal health outcomes. Evidence relating to macro and micronutrient requirements, their deficiency its risks, and consequences still remain a gap of knowledge. Objectives: The aim of this study was to assess the nutrient intake of pregnant women with altered iodine status in the Mysuru region. Methods: A hospital-based cross-sectional study was conducted and random spot urine samples (n=110) were collected to determine Urinary iodine concentration (UIC). Three-day 24hr recall and FFQ were collected to …

Research Article A New Informatics Framework For Evaluating The Codon Usage Metrics, Evolutionary Models And Phylogeographic Reconstruction Of Tomato Yellow Leaf Curl Virus (Tylcv) In Different Regions Of Asian Countries, Mamathashree Mn, Kuralyanapalya Putta Honnappa Suresh, Sharanagouda S Patil, Uma Bharathi Indrabalan, Mallikarjun S Beelagi, Sushma Pradeep, Krishnamoorthy Paramanandham, Siju Susan Jacob, Chandrashekar Srinivasa, Shiva Prasad Kollur, Raghu Ram Achar, Ashwini Prasad, Shashanka K Prasad, Chandan Shivamallu

International Journal of Health and Allied Sciences

Tomato yellow leaf curl virus (TYLCV) is a major devastating viral disease, majorly affecting the tomato production globally. The disease is majorly transmitted by the Whitefly. The Begomovirus (TYLCV) having a six major protein coding genes, among them the C1/AC1 is evidently associated with viral replication. Owing to immense role of C1/AC1 gene, the present study is an initial effort to elucidate the factors shaping the codon usage bias and evolutionary pattern of TYLCV-C1/AC1 gene in five major Asian countries. Based on publically available nucleotide sequence data the Codon usage pattern, Evolutionary and Phylogeographic reconstruction was carried out. The study …

Bio Prospecting Of Lapachol Producing Endophytic Fungi, Chandrashekar Srinivasa, Sushma Pradeep, Shashank M Patil, Ramith Ramu, Shiva Prasad Kollur, Shashanka K Prasad, Chandan Shivamallu

International Journal of Health and Allied Sciences

Background: The association of endophytic fungi with medicinal plants has been one of the evolving areas of research in the past few decades. The secondary metabolites produced owing to such associations have been recognised for a wide range of biological activities. Objectives: The aim of the present review is to highlight the isolation of lapachol from endophytic microorganisms with an emphasis on its biotransformation to improve its efficacy. Methodology: The researchers followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria. Published scientific articles on endophytes, host-pathogen interaction and lapachol isolation were collected from reputed journals from …

Artificial Intelligence And Machine Learning Based Techniques In Analyzing The Covid-19 Gene Expression Data: A Review, Santhosh K, Ajitha S, Sushma Pradeep, Kuralyanapalya Putta Honnappa Suresh, Sharanagouda S Patil, Shiva Prasad Kollur, Chandan Shivmallu

International Journal of Health and Allied Sciences

The novel Coronavirus associated with respiratory illness has become a new threat to human health as it is spreading very rapidly among the human population. Scientists and healthcare specialists throughout the world are still looking for a breakthrough technology to help combat the Covid-19 outbreak, despite the recent worldwide urgency. The use of Machine Learning (ML) and Artificial Intelligence (AI) in earlier epidemics has encouraged researchers by providing a fresh approach to combating the latest Coronavirus pandemic. This paper aims to comprehensively review the role of AI and ML for analysis of gene expressed data of COVID-19

Racial And Ethnic Differences In The Receipt Of Metabolic Syndrome Risk Factor Screening And Treatment Among Prostate Cancer Patients Treated With Androgen Deprivation Therapy., Yazan K. Barqawi

Pharmaceutical Sciences ETDs

Background: Racial and ethnic health disparities in prostate cancer prevalence, incidence, mortality, quality of life, screening, and treatment constitute the largest of all cancer disparities. These health disparities are associated with higher morbidity and mortality rates in minority populations. Treatment with androgen deprivation therapy (ADT) has been the most widely used therapeutic modality to reduce the progression of prostate cancer to a worse disease stage and relieve potential obstructive symptoms. However, ADT is associated with possible toxic metabolic and cardiovascular (CVS) adverse events that may occur within six months of ADT initiation. These adverse events include metabolic syndrome, type II …

Swosu Fall 2022 Convocation, Southwestern Oklahoma State University

Graduation Programs

This is the program for the SWOSU Fall 2022 Convocation Exercises, held at the Pioneer Cellular Events Center on Friday, December 16, 2022, at 6:00 pm. Opening Remarks were presented by President Diana Lovell.

Senior Recognition Ceremony 2022

Commencement Programs

No abstract provided.

Fertility Considerations In Prescribing Hormonal Contraceptives In Individuals With Polycystic Ovary Syndrome, Andrea M. Reichle, Justin Gambini

Doctor of Medical Science (DMSc)

Polycystic ovary syndrome (PCOS) is a highly prevalent endocrine disorder and the most common cause of infertility among females of reproductive age.1 While the name “polycystic ovary syndrome” implies people diagnosed with PCOS have numerous cysts on their ovaries, this is not always the case. Clinicians currently use the Rotterdam criteria to diagnose PCOS.2 These criteria include: irregular periods/anovulatory cycles, clinical or biochemical signs of androgen excess (acne, hirsutism, androgenic alopecia, etc.), and numerous ovarian cysts seen on imaging.2 A diagnosis of PCOS can be made when at least two of three criteria are met.2 As this has become a …

Special Topics In Neuroendocrinology Allopregnanolone: Pathophysiology, Effects On Mood, Emerging Treatments, Sarah Jane Lance, Justin Gambini

Doctor of Medical Science (DMSc)

KEY POINTS

● Allopregnanolone is a neurosteroid and metabolite of progesterone that has been shown to play a role in mood regulation.

● Low levels and rapid declines in this neurosteroid are associated with mood disorders such as those within the menstrual cycle, postpartum depression, chronic stress, anxiety, post-traumatic stress disorder, and major depression. Studies have also linked it to moodrelated aspects of addiction.

● Medications that increase allopregnanolone, such as serotonin reuptake inhibitors and Brexanolone, are correlated with improved symptoms. These medications represent established and newly developed drugs that increase its level and are currently used for treatments of …

Children Are A Heritage From The Lord: A Procreation-Centric Approach To Christian Marriage And Family Education, Nicholas Lee Hagerman

Doctor of Ministry Major Applied Project

Hagerman, Nicholas L. "Children Are a Heritage from the Lord: A Procreation-Centric Approach to Christian Marriage and Family Education." Doctor of Ministry. Major Applied Project, Concordia Seminary, 2022. 242 pp.

As youth and young adults are being raised in the church, they are often taught about issues related to sex and marriage. However, procreation and raising families are rarely mentioned in such teaching, which tends to focus instead on relational issues between spouses, the avoidance of sexual sins, and the marital institution's reflection of the relationship between Christ and His church. This project seeks to remedy this deficiency by taking …

Elevation Influences The Microhabitat Use And Baseline Physiology Of Coqui Frogs In Hawai‘I, Karen H. Beard, Susannah S. French, Jack Marchetti

Browse all Datasets

The purpose of this study was to determine whether elevation in HawaiÔi affects the coquiÕs microhabitat use such as substrate choice and height off the forest floor and physiological metrics such as osmolality, oxidative status, and energy metabolites (glucose, free glycerol, and triglycerides).

Multiplex Immunofluorescence-Guided Laser Capture Microdissection For Spatial Transcriptomics Of Metastatic Melanoma Tissues., Jan Martinek, Te-Chia Wu, Lili Sun, Jianan Lin, Kyung In Kim, Florentina Marches, Paul Robson, Joshy George, Karolina Palucka

Faculty Research 2022

We describe a pipeline for optimized and streamlined multiplexed immunofluorescence-guided laser capture microdissection allowing the harvest of individual cells based on their phenotype and tissue localization for transcriptomic analysis with next-generation RNA sequencing. Here, we analyze transcriptomes of CD3+ T cells, CD14+ monocytes/macrophages, and melanoma cells in non-dissociated metastatic melanoma tissue. While this protocol is described for melanoma tissues, we successfully applied it to human tonsil, skin, and breast cancer tissues as well as mouse lung tissues. For complete details on the use and execution of this protocol, please refer to Martinek et al. (2022).

Extrachromosomal Dna (Ecdna): An Origin Of Tumor Heterogeneity, Genomic Remodeling, And Drug Resistance., Lauren T Pecorino, Roel G W Verhaak, Anton Henssen, Paul S Mischel

Faculty Research 2022

The genome of cancer cells contains circular extrachromosomal DNA (ecDNA) elements not found in normal cells. Analysis of clinical samples reveal they are common in most cancers and their presence indicates poor prognosis. They often contain enhancers and driver oncogenes that are highly expressed. The circular ecDNA topology leads to an open chromatin conformation and generates new gene regulatory interactions, including with distal enhancers. The absence of centromeres leads to random distribution of ecDNAs during cell division and genes encoded on them are transmitted in a non-mendelian manner. ecDNA can integrate into and exit from chromosomal DNA. The numbers of …