Digital Commons Network^™

Emerin Interacts With Histone Methyltransferases To Regulate Repressive Chromatin At The Nuclear Periphery., Nicholas Marano, James M. Holaska

Cooper Medical School of Rowan University Departmental Research

X-Linked Emery-Dreifuss muscular dystrophy is caused by mutations in the gene encoding emerin. Emerin is an inner nuclear membrane protein important for repressive chromatin organization at the nuclear periphery. Myogenic differentiation is a tightly regulated process characterized by genomic reorganization leading to coordinated temporal expression of key transcription factors, including MyoD, Pax7, and Myf5. Emerin was shown to interact with repressive histone modification machinery, including HDAC3 and EZH2. Using emerin-null myogenic progenitor cells we established several EDMD-causing emerin mutant lines in the effort to understand how the functional interaction of emerin with HDAC3 regulates histone methyltransferase localization or function to …

Stony Brook Press, V. 44, N. 01, Stony Brook University. Stony Brook Press.

Stony Brook Press

v. 36,n. 4, v.:ill. ; 38 cm (original analog pub.)

Bird Species Define The Relationship Between West Nile Viremia And Infectiousness To Culex Pipiens Mosquitoes, Jefferson A. Vaughan, Robert Newman, Michael J. Turrell

Biology Faculty Publications

The transmission cycle of West Nile virus (WNV) involves multiple species of birds. The relative importance of various bird species to the overall transmission is often inferred from the level and duration of viremia that they experience upon infection. Reports utilizing in vitro feeding techniques suggest that the source and condition of blood in which arboviruses are fed to mosquitoes can significantly alter the infectiousness of arbovirus to mosquitoes. We confirmed this using live hosts. A series of mosquito feedings with Culex pipiens was conducted on WNV-infected American robins and common grackles over a range of viremias. Mosquitoes were assayed …

Goofus And Gallant’S Guide To Textbook Cataloging, Scott Dutkiewicz

Presentations

Though a long-neglected genre in academic libraries, acquisitions of textbooks are on the rise. But textbooks often do not receive adequate cataloging attention. How can catalogers improve their practices? Inspired by the Highlights for Children comic strip, this presentation discusses five “goofs” and five “gallant” practices when cataloging textbooks.

The Role Of Ubiquitination In Spinal And Bulbar Muscular Atrophy, Medha Sengupta, Anna Pluciennik, Diane E. Merry

Department of Biochemistry and Molecular Biology Faculty Papers

Spinal and bulbar muscular atrophy (SBMA) is a neurodegenerative and neuromuscular genetic disease caused by the expansion of a polyglutamine-encoding CAG tract in the androgen receptor (AR) gene. The AR is an important transcriptional regulator of the nuclear hormone receptor superfamily; its levels are regulated in many ways including by ubiquitin-dependent degradation. Ubiquitination is a post-translational modification (PTM) which plays a key role in both AR transcriptional activity and its degradation. Moreover, the ubiquitin-proteasome system (UPS) is a fundamental component of cellular functioning and has been implicated in diseases of protein misfolding and aggregation, including polyglutamine (polyQ) repeat expansion diseases …

The Montclarion, October 06, 2022, The Montclarion

The Montclarion

Student Newspaper of Montclair State University

Above- And Belowground Responses To Environmental Change In The Northern Chihuahuan Desert, Renée Françoise Brown

Biology ETDs

Drylands cover 45% of the terrestrial surface and are expanding rapidly due to anthropogenic drivers. Altered precipitation regimes, atmospheric nitrogen deposition, and wildfire will likely have significant consequences in these regions where ecological processes are limited by water and nitrogen. In this dissertation, I explored temporal dynamics of net primary production (NPP) and related above- and belowground processes under several environmental change drivers in the Sevilleta National Wildlife Refuge, central New Mexico, USA. Located in the northern Chihuahuan Desert, this region experiences strong seasonal precipitation patterns driven by the North American Monsoon, historically characterized by frequent small rain events hypothesized …

Low Levels Of Hybridization Between Domestic And Wild Mallards Wintering In The Lower Mississippi Flyway, J. Brian Davis, Diana C. Outlaw, Kevin M. Ringelman, Richard M. Kaminski, Philip Lavretsky

Faculty Publications

The Mallard (Anas platyrhynchos) duck is a ubiquitous and socio-economically important game bird in North America. Despite their generally abundant midcontinent population, Mallards in eastern North America are declining, which may be partially explained by extensive hybridization with human-released domestically derived game-farm Mallards. We investigated the genetic composition of Mallards in the middle and lower Mississippi flyway, key wintering regions for the species. We found that nearly 30% of wild Mallards carried mitochondrial (mtDNA) haplotypes derived from domestic Mallards present in North America, indicating that the individuals had female game-farm Mallard lineage in their past; however, nuclear results identified only …

The Effect Of Infection Risk On Female Blood Transcriptomics, Brenna M. G. Gormally, Patricia C. Lopes

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Defenses against pathogens can take on many forms. For instance, behavioral avoidance of diseased conspecifics is widely documented. Interactions with these infectious conspecifics can also, however, lead to physiological changes in uninfected animals, an effect that is much less well understood. These changes in behavior and physiology are particularly important to study in a reproductive context, where they can impact reproductive decisions and offspring quality. Here, we studied how an acute (3 h) exposure to an immune-challenged male affected female blood transcriptomics and behavior. We predicted that females paired with immune-challenged males would reduce eating and drinking behaviors (as avoidance …

Inhibiting S100Β And Troubleshooting Cell Growth, Animesh Dali, Suhana Basnyat, Robert Passarelli, Nipun Chopra

Annual Student Research Poster Session

S100B is a protein that is upregulated in neuronal injury. The upregulation of S100B has been observed to start multiple cascades that result in neuronal death. The inhibition of S100B would be a promising treatment for neuronal injury. In our research, we attempt to do exactly so.

Introduction To Common Molecular Biological Techniques Used In Research Laboratories, Dington Tan, Ruitang Deng, Winifer Ali, Qiwen Chen

Annual Student Research Poster Session

The main techniques used in molecular biology are cloning, PCR (Polymerase Chain Reaction), nucleic acid electrophoresis, DNA microarray analysis, in situ hybridization (HIS), sequencing (Sanger or Next Generation Sequencing (NGS)). Molecular biology techniques are extremely valuable for addressing a wide range of issues impacting the general state of humanity, in addition to investigating fundamental scientific concerns. Applications for molecular biology techniques include the prevention and treatment of disease, the creation of new protein products, and the modification of plants and animals to produce desired phenotypic traits.

Latex Induction And Effects Of Herbivory On Apocynum Cannabinum, Shiley Claypool, Tim Douglas, Rose Keith

Annual Student Research Poster Session

Apocynum cannabinum, also known as hemp dogbane, is a species of perennial native to the U.S. This species has been found to be extremely plastic, meaning that its environment has significant effects on its phenotypic traits (Ransom et al. 1998). Plant-herbivore interactions, such as herbivory, can drive this plasticity. One of these responses includes the induction of Latex, a white sappy fluid that exits leaves and stems induced by damage (Agrawal and Konno 2009). This project investigates the effects of early-season vs. late-season herbivory on hemp dogbane, as well as how latex induction is influenced by these plant-herbivore interactions.

Faculty Senate Chronicle October 6, 2022, Heather M. Loughney

The University of Akron Faculty Senate Chronicle

No abstract provided.

October 2022 Faculty Senate Packet, University Of Nebraska At Kearney Faculty Senate

Faculty Senate Packets

No abstract provided.

The Risk And Clinical Implications Of Antibiotic-Associated Acute Kidney Injury: A Review Of The Clinical Data For Agents With Signals From The Food And Drug Administration’S Adverse Event Reporting System (Faers) Database, Kalin M. Clifford, Ashley R. Selby, Kelly R. Reveles, Chengwen Teng, Ronald G. Hall Ii, Jamie Mccarrell, Carlos A. Alvarez

Faculty Publications

Antibiotic-associated acute kidney injury (AA-AKI) is quite common, especially among hospitalized patients; however, little is known about risk factors or mechanisms of why AA-AKI occurs. In this review, the authors have reviewed all available literature prior to 1 June 2022, with a large number of AKI reports. Information regarding risk factors of AA-AKI, mechanisms behind AA-AKI, and treatment/management principles to decrease AA-AKI risk were collected and reviewed. Patients treated in the inpatient setting are at increased risk of AA-AKI due to common risk factors: hypovolemia, concomitant use of other nephrotoxic medications, and exacerbation of comorbid conditions. Clinicians should attempt to …

The Grizzly, October 6, 2022, Layla Halterman, Amelia Kunko, Allia Proctor, Kate Horan, Jenna Smith, Quadai Brown

Ursinus College Grizzly Newspaper, 1978 to Present

Remembering Adam Walton '25 • Fall 2022 Editorial Staff • Meet Dr. Rebecca Lyczak and Her Research Team • Get Your Life in Shape With Laura Cunningham • Opinions: First-Year Athlete Check-in • Men's and Women's Tennis Back on Their Home Courts! • Mary Lauren Franz Scores Two Goals Against WAC! • New Health Hub Coming Soon! • Upcoming Games

Roosts Of Northern Long-Eared Myotis (Myotis Septentrionalis) At The Western Edge Of The Great Plains, Brett R. Andersen, Keith Geluso

Western North American Naturalist

The northern long-eared myotis (Myotis septentrionalis) is a forest-obligate, tree-roosting bat of the United States and Canada. Most prior studies on roost characteristics were conducted in contiguous forested habitats of eastern North America, where roosting opportunities are potentially numerous. At the western end of its distribution in the Great Plains, M. septentrionalis inhabits narrow, forested riparian waterways. Because these ribbons of forest differ from habitats farther east, roost selection by M. septentrionalis at the western edge of its distribution might differ and affect management practices in the region. Moreover, M. septentrionalis is imperiled by a deadly fungal …

Ribosomal Rack1 Regulates The Dendritic Arborization By Repressing Fmrp Activity, Nicla Romano, Bruna Di Giacomo, Veronica Nobile, Antonella Borreca, Daniela Willems, Francesca Tilesi, Elisabetta Catalani, Manasi Agrawal, Kristy Welshhans, Sara Ricciardi, Davide Cervia, Marcello Ceci

Faculty Publications

FMRP is an RNA-binding protein that represses the translation of specific mRNAs. In neurons, its depletion determines the exaggerated translation of mRNAs leading to dendritic and axonal aberrant development, two peculiar features of Fragile X syndrome patients. However, how FMRP binds to translational machinery to regulate the translation of its mRNA targets is not yet fully understood. Here, we show that FMRP localizes on translational machinery by interacting with the ribosomal binding protein, Receptor for Activated C Kinase 1 (RACK1). The binding of FMRP to RACK1 removes the translational repressive activity of FMRP and promotes the translation of PSD-95 mRNA, …

Physicochemical And Antibacterial Properties Of Conventional And Two Premixed Root Canal Filling Materials In Primary Teeth, Claire El Hachem, Jean C.A. Chedid, Walid Nehme, Marc K. Kaloustian, Nabil Ghosn, Hafsa Sahnouni, Davide Mancino, Youssef Haikel, Naji Kharouf

Pacific Faculty Work

In this study, some physicochemical and antibacterial properties of three root canal filling materials for primary teeth, Calplus “CP” (Prevest DenPro, Lewes, DE, USA), Bio-C Pulpecto “Bio-CP” (Angelus, Basil, Londrina, Paraná, Brazil), and Zinc Oxide and Eugenol “ZOE” (Prevest DenPro, Lewes, DE, USA) were compared. For each material, the pH, solubility, contact angle, and crystalline microstructure under SEM were evaluated. Their antibacterial activity against Enterococcus faecalis was determined through direct tests. The Kruskal–Wallis test was used to analyze the results using a one-way analysis of variance on ranks. All the materials had an alkaline pH at 3, 24, and 72 …

Response Of Soil Bacterial Diversity, Predicted Functions And Co-Occurrence Patterns To Nanoceria And Ionic Cerium Exposure, Jie Zhang, Hui Sheng, Yan-Meng Shang, Jamie Lead, Zhang-Zhen Guo, Jian-Ping Hong

Faculty Publications

Release of nanoceria (nCeO₂) into the environment has caused much concern about its potential toxicity, which still remains poorly understood for soil microorganisms. In this study, nanoceria and cerium (III) nitrate at different doses (10, 100 and 500 mg/kg) were applied to bok choy (Brassica rapa subsp. chinensis), grown in potting soil, to investigate the responses of soil bacterial communities to nanoceria (NC) and ionic cerium (IC) applications. The results showed that bacterial richness was slightly increased in all cerium treatments relative to the negative control without cerium amendment (CK), but a significant increase was only found in …

The Genomic And Bulked Segregant Analysis Of Curcuma Alismatifolia Revealed Its Diverse Bract Pigmentation, Xuezhu Liao, Yuanjun Ye, Xiaoni Zhang, Dan Peng, Mengmeng Hou, Gaofei Fu, Jianjun Tan, Jianli Zhao, Rihong Jiang, Yechun Xu, Jinmei Liu, Jinliang Yang, Wusheng Liu, Luke R. Tembrock, Genfa Zhu, Zhiqiang Wu

Department of Agronomy and Horticulture: Faculty Publications

Compared with most flowers where the showy part comprises specialized leaves (petals) directly subtending the reproductive structures, most Zingiberaceae species produce showy ‘‘flowers’’ through modifications of leaves (bracts) subtending the true flowers throughout an inflorescence. Curcuma alismatifolia, belonging to the Zingiberaceae family, a plant species originating from Southeast Asia, has become increasingly popular in the flower market worldwide because of its varied and esthetically pleasing bracts produced in different cultivars. Here, we present the chromosome-scale genome assembly of C. alismatifolia ‘‘Chiang Mai Pink’’ and explore the underlying mechanisms of bract pigmentation. Comparative genomic analysis revealed C. alismatifolia contains a …

Deans, Chairs And Program Directors List 2022-2023 (Fall), Saint Mary's College Of California

Chairs and Program Directors lists

No abstract provided.

Brain Age Predicts Long-Term Recovery In Post-Stroke Aphasia, Sigfus Kristinsson, Natalie Busby, Christopher Rorden, Roger Newman-Norlund, Dirk B. Den Ouden, Sigridur Magnusdottir, Haukur Hjaltason, Helga Thors, Argye E. Hillis, Olafur Kjartansson, Leonardo Bonilha, Julius Fridriksson

Communication Sciences and Disorders Faculty Articles and Research

The association between age and language recovery in stroke remains unclear. Here, we used neuroimaging data to estimate brain age, a measure of structural integrity, and examined the extent to which brain age at stroke onset is associated with (i) cross-sectional language performance, and (ii) longitudinal recovery of language function, beyond chronological age alone. A total of 49 participants (age: 65.2 ± 12.2 years, 25 female) underwent routine clinical neuroimaging (T1) and a bedside evaluation of language performance (Bedside Evaluation Screening Test-2) at onset of left hemisphere stroke. Brain age was estimated from enantiomorphically reconstructed brain scans using a machine …

Biogenesis And Regulatory Roles Of Circular Rnas, Li Yang, Jeremy E Wilusz, Ling-Ling Chen

Children’s Nutrition Research Center Staff Publications

Covalently closed, single-stranded circular RNAs can be produced from viral RNA genomes as well as from the processing of cellular housekeeping noncoding RNAs and precursor messenger RNAs. Recent transcriptomic studies have surprisingly uncovered that many protein-coding genes can be subjected to backsplicing, leading to widespread expression of a specific type of circular RNAs (circRNAs) in eukaryotic cells. Here, we discuss experimental strategies used to discover and characterize diverse circRNAs at both the genome and individual gene scales. We further highlight the current understanding of how circRNAs are generated and how the mature transcripts function. Some circRNAs act as noncoding RNAs …

Engaging With Politics, Policy, & Policymaking: Opportunities And Challenges For Sigma Members Worldwide, Enrique Castro-Sanchez, Roya Haghiri-Vijeh, Brooke Newman, Michael J. Polacek

General Webinars

The webinar will explore the interests and skills of nurses in political decision-making and discuss opportunities to increase the minimal involvement of nurses in legislative policymaking and how to best foster more nurse engagement as policymakers, political stakeholders, and activists. The panel aims to dialogue with participants, providing education regarding the next steps and implications for practice improvement(s).

Molecular Pathways Of Major Depressive Disorder Converge On The Synapse, Gabriel R Fries, Valeria A Saldana, Johannes Finnstein, Theo Rein

Faculty, Staff and Student Publications

Major depressive disorder (MDD) is a psychiatric disease of still poorly understood molecular etiology. Extensive studies at different molecular levels point to a high complexity of numerous interrelated pathways as the underpinnings of depression. Major systems under consideration include monoamines, stress, neurotrophins and neurogenesis, excitatory and inhibitory neurotransmission, mitochondrial dysfunction, (epi)genetics, inflammation, the opioid system, myelination, and the gut-brain axis, among others. This review aims at illustrating how these multiple signaling pathways and systems may interact to provide a more comprehensive view of MDD's neurobiology. In particular, considering the pattern of synaptic activity as the closest physical representation of mood, …

Feasibility Of A Novel Non-Invasive Swab Technique For Serial Whole-Exome Sequencing Of Cervical Tumors During Chemoradiation Therapy, Julianna K Bronk, Chiraag Kapadia, Xiaogang Wu, Bhavana V Chapman, Rui Wang, Tatiana V Karpinets, Xingzhi Song, Andrew M Futreal, Jianhua Zhang, Ann H Klopp, Lauren E Colbert

Faculty, Staff and Student Publications

BACKGROUND: Clinically relevant genetic predictors of radiation response for cervical cancer are understudied due to the morbidity of repeat invasive biopsies required to obtain genetic material. Thus, we aimed to demonstrate the feasibility of a novel noninvasive cervical swab technique to (1) collect tumor DNA with adequate throughput to (2) perform whole-exome sequencing (WES) at serial time points over the course of chemoradiation therapy (CRT).

METHODS: Cervical cancer tumor samples from patients undergoing chemoradiation were collected at baseline, at week 1, week 3, and at the completion of CRT (week 5) using a noninvasive swab-based biopsy technique. Swab samples were …

The Student Movement Volume 107 Issue 4: So Glad To Live In A World Where There Are Octobers: Au Welcomes Autumn, Anna Pak, Nora Martin, Kavya Mohanram, Solana Campbell, Hannah Cruse, Nora Martin, Andrew Francis, Taznir Smalling, Terika Williams, Ralph Gifford, Zothile Sibanda, Ruben Colón, Abraham Bravo, Alannah Tjhatra

The Student Movement v. 107 (2022-2023)

HUMANS

Following in Amelia's Footsteps, Interviewed by: Anna Pak

Meet Hailey Prestes, AUSA Social VP, Interviewed by: Nora Martin

History of the James White Library, Interviewed by: Kavya Mohanram

ARTS & ENTERTAINMENT

Currently...On Campus, Solana Campbell

Daddy Yankee, Hannah Cruse

En Español, Nora Martin

NEWS

Andrews Faculty Member Enter the "Shark Tank", Andrew Francis

Andrews University: The Vegetarian Hotpot, Taznir Smalling

Writing Center - Back in Person!, Hannah Cruse

IDEAS

Hispanic Heritage Entering the MCU

The Importance of Spanish in American Society and the Classroom, Terika Williams

The Right to Choose: An Analysis of the Protests in Iran, Terika Willaims …

Continuous Npwt Regulates Fibrosis In Murine Diabetic Wound Healing, Mengfan Wu, Dany Y Matar, Zhen Yu, Ziyu Chen, Samuel Knoedler, Brian Ng, Oliver A Darwish, Sadaf Sohrabi, Leigh Friedman, Valentin Haug, George F Murphy, Yuval Rinkevich, Dennis P Orgill, Adriana C Panayi

2020-Current year OA Pubs

Scarring is associated with significant morbidity. The mechanical signaling factor yes-associated protein (YAP) has been linked to Engrailed-1 (En1)-lineage positive fibroblasts (EPFs), a pro-scarring fibroblast lineage, establishing a connection between mechanotransduction and fibrosis. In this study, we investigate the impact of micromechanical forces exerted through negative pressure wound therapy (NPWT) on the pathophysiology of fibrosis. Full-thickness excisional dorsal skin wounds were created on diabetic (db/db) mice which were treated with occlusive covering (control) or NPWT (continuous, -125 mmHg, 7 days; NPWT). Analysis was performed on tissue harvested 10 days after wounding. NPWT was associated with increased YAP (

Tolkien, Race, And Racism In Middle-Earth (2022) By Robert Stuart, Dimitra Fimi

Journal of Tolkien Research

Book review, by Dimitra Fimi, of Tolkien, Race, and Racism in Middle-earth (2022) by Robert Stuart