Digital Commons Network^™

A Note From The Executive Editor, Judith D. Ochrietor

PANDION: The Osprey Journal of Research and Ideas

No abstract provided.

Continuous Downstream Process Of Monoclonal Antibody Developed Based On The Process Analysis/Understanding And Its Validation, Shuichi Yamamoto, Fuminori Konoike, Noriko Yoshimoto

Integrated Continuous Biomanufacturing V

As downstream process (DSP) of monoclonal antibody (mAb) includes several batch chromatography steps, and other operations such as virus inactivation (VI), it is important to consider how each operation is carried out in order to make an efficient continuous or pseudo-continuous DSP. Our consortium* developed a continuous DSP (CDSP) of mAb under the AMED** project “Development of platform technologies for the continuous manufacturing of biopharmaceuticals”, and successfully carried out several runs at our GMP facility and laboratory. In this paper, we will present how our CDSP was developed based on the process analysis and understanding, and the purification results along …

We Are ... Marshall, October 12, 2022, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

Usa Archaeology Museum Newsletter - October 2022, Archaeology Museum

Archaeology Museum Newsletters

In this edition of the Archaeology Museum's newsletter:

• October is Alabama Archaeology Month (ways to celebrate):

1. October's GulfChat presentation: Piracy and Privateering in the Gulf of Mexico From 1500-1820
2. Archaeology of Down the Bay: The Old Water Street Site
3. A Very Batty Halloween at the Museum!
4. Down the Bay Photo Sharing Day

Feminist Academic Organizations: Challenging Sexism Through Collective Mobilizing Across Research, Support, And Advocacy, Lauren Gurrieri, Andrea Prothero, Shona Bettany, Susan Dobscha, Jenna Drenten Ph.D., Shelagh Ferguson, Stacey Finkelstein, Laura Mcvey, Nacima Ourahmoune, Laurel Steinfield, Linda Tuncay Zayer

School of Business: Faculty Publications and Other Works

This paper examines the establishment of a feminist academic organization, GENMAC (Gender, Markets, and Consumers; genmac.co), serving gender scholars in business schools and related fields. In so doing, it builds on the emerging literature of feminist academic organizations, as situated within feminist organizational studies (FOS). Through a feminist case study and by assessing the reflections of GENMAC's board members, we tell the story of the emergence of GENMAC and detail the tensions the organization encountered as it formally established itself as a feminist organization within the confines of a business school setting, a patriarchal system, and a neoliberal university paradigm. …

Effects Of Depth And Cover Crop Treatment On The Functioning And Diversity Of Soil Microbial Communities, Emily N. Hansen

Theses and Dissertations

Globally, agriculture is strained by the unpredictable effects of climate change, as well as flooding, drought, erosion, and decreases in soil fertility. To meet these challenges, agricultural systems must develop new techniques while promoting sustainable intensification practices. Cover crops can provide farmers with an off-season cash crop, while also positively impacting the soil and reducing reliance on less sustainable conventional farming practices. The objective of this research was to evaluate the impact of different cover crops on soil microbial communities at varying depths. Soils were sampled in the fall and spring from experimental plots (ISU Farm, Lexington, IL) that contained …

The Current - Volume 33 Issue 1, Nova Southeastern University

Student Newspapers

No abstract provided.

How Hearing Parents With Deaf Or Hard Of Hearing Children Construct Deafness Through Their Early Intervention Experience, Bettie T. Petersen

Language, Literacy, and Sociocultural Studies ETDs

This dissertation explores how hearing parents with deaf/hard of hearing children come to understand deafness. This mixed methods study used an online survey and multiple case studies (volunteers from survey). Participants were asked about early intervention experiences and beliefs about deafness. The survey had 74 respondents and five families participated in the interviews. Survey participants’ beliefs about deafness were primarily medical, focusing on the perceived barriers caused by deafness and the remediation of those barriers through spoken language options. A small number of respondents adopted a cultural perspective of deafness and focused on remediation of barriers through involvement in the …

Alu Dimorphism At The Pv92 Locus Of Chromosome 16 Is In Equilibrium For University Student Population, James M. Brooks, Mackenzie L. Thackston

Journal of the South Carolina Academy of Science

Alu is a retrotransposable element, which refers to its ability to be copied and move from one region of DNA to another DNA region. At the PV92 locus of chromosome 16, Alu is a 300 bp dimorphic insert that can either be present or absent. It does not encode a protein product and has lost the ability to transpose. It is specific to humans, and differences in genotype and allele frequencies between human populations are important tools in understanding evolution. In this research, data was obtained and analyzed from 269 students at Charleston Southern University (CSU) belonging to four different …

2022 Scas Annual Meeting Program And Bulletin

Journal of the South Carolina Academy of Science

No abstract provided.

Table Of Contents

Journal of the South Carolina Academy of Science

No abstract provided.

Environmental Bacteriophage Detection On Coastal Carolina University Campus, Madison Gentilo, Hailey Oldfield, Gavin Ockert, Paul E. Richardson

Journal of the South Carolina Academy of Science

Bacteriophages are viruses that infect bacteria. These viruses are found ubiquitously in the environment and are more abundant than any living organism on Earth, including bacteria. Eleven sites are designated for weekly sample collection on the campus of Coastal Carolina University. Water samples are filtered and amplified using strains of E. coli B and E. coli K12 to allow potential coliphages in the sample to proliferate to detectable levels. Plaque assays are used as a microbial screen for the presence of bacteriophage. Samples that test positively using the microbial test are analyzed through a molecular test using PCR to identify …

Salt Marsh Plant Community Structure On Horse Island, South Carolina, Mackenzie L. Jenkins, Jennifer L. Schafer

Journal of the South Carolina Academy of Science

Sea level rise is causing an increase in salt water encroachment and flooding in many coastal habitats, and increasing salinity can have negative impacts on plant communities. The objective of our research was to determine the impact of salinity on salt marsh plant community structure on Horse Island, South Carolina. We investigated variation in plant cover and height with distance from a tidal creek and the effect of increasing salinity on seedling emergence from the seed bank. We established three transects in the salt marsh habitat and recorded plant species presence, percent cover of each species, and height of the …

3,6-Dimethoxyxanthone From 2,2’,4,4’- Tetrahydroxy-Benzophenone Via Microwave-Assisted Annulation, Sarah E. Knisely, Faith R. Rosario, Salem F. Gebeyehu, Paige E. Heiple, Robert E. Lee Sr

Journal of the South Carolina Academy of Science

Xanthones are tricyclic aromatic compounds that have multiple pharmacological uses due to their anti-tumor, antioxidant, anti-inflammatory, anti-bacterial, and potentially chemopreventive properties. The target of this research was to optimize a two-step synthesis of 3,6-dimethoxyxanthone (3) from 2,2’,4,4’-tetrahydroxy-benzophenone (1) via microwave-assisted (200 °C, 30-40 min., 150 W) sodium acetate-catalyzed annulation. The product, 3,6-dihydroxyxanthone (2), was then methylated to (3) using dimethyl sulfate (DMS) and sodium carbonate in acetone at reflux. The product yields were 93% (>99% purity) for (2) and 94% (>99% purity) for (3). Characterization was accomplished using ¹H NMR, FTIR, melting point, TLC, HPLC, and GCMS. …

The Effects Of Human Behavioral Changes Due To The Covid-19 Pandemic On The Reservoir Of Lytic Escherichia Coli And Staphylococcus Aureus Bacteriophage On Humans At A South Carolina University, Korinne M. Swanson, Owen R. Smith, Paul E. Richardson

Journal of the South Carolina Academy of Science

Bacteriophages are viruses, whose unique ability to infect and lyse bacterial cells may provide valuable insight for evading the repercussions of a post-antibiotic era in medicine. This study isolated and characterized Escherichia coli and Staphylococcus aureus bacteriophage on students and faculty at Coastal Carolina University as a means to understand the viability of human bacteriophage reservoirs for bacteriophage therapy. From September 2021 to March 2022, nasal and postauricular swab samples and a behavioral survey were collected from ninety-three randomly selected participants. Additionally, sixteen participants contributed nasal and postauricular swab samples and a behavioral survey on a monthly basis in a …

Professor Using Grant To Study Molecular Mechanisms That Sustain Life, Lou Tyson

University of Mississippi News

Nikki Reinemann receives $1.5 million grant from National Institutes of Health

Connecting Phenotype To Genotype: Phewas-Inspired Analysis Of Autism Spectrum Disorder, John Matta, Daniel Dobrino, Dacosta Yeboah, Swade Howard, Yasser El-Manzalawy, Tayo Obafemi-Ajayi

Electrical and Computer Engineering Faculty Research & Creative Works

Autism Spectrum Disorder (ASD) is extremely heterogeneous clinically and genetically. There is a pressing need for a better understanding of the heterogeneity of ASD based on scientifically rigorous approaches centered on systematic evaluation of the clinical and research utility of both phenotype and genotype markers. This paper presents a holistic PheWAS-inspired method to identify meaningful associations between ASD phenotypes and genotypes. We generate two types of phenotype-phenotype (p-p) graphs: a direct graph that utilizes only phenotype data, and an indirect graph that incorporates genotype as well as phenotype data. We introduce a novel methodology for fusing the direct and indirect …

Predictors Of Preschool Language Environments And Their Relations To Children's Vocabulary, Robert Duncan, Kirsten L. Anderson, Yemimah A. King, Jennifer Finders, Sara A. Schmitt, David J. Purpura

Purdue Center for Early Learning Faculty and Staff Publications

Despite support for the importance of early language environments, little is known about the naturally occurring experiences children have in preschool settings. The current study sample included 91 children (Mage = 4.72 years; 56% male; 67% White) from 23 preschool classrooms and nearly 1500 h of language environment data from three waves throughout the preschool year. Of the sociodemographic characteristics, family income is most closely related to children's preschool language environments. A standard deviation increase in family income was related to children hearing approximately one million more adult words in their preschool classroom. However, conversational turns were the …

Combined Effects Of Scarification, Phytohormones, Stratification, And Soil Type On The Germination And/Or Seedling Performance Of Three Tamaulipan Thornscrub Forest Species, Paula Luera, Christopher A. Gabler

School of Earth, Environmental, & Marine Sciences Faculty Publications

Tamaulipan thornforests in south Texas and northeast Mexico are a conservation hotspot. Shortages of native seedlings limit regional restoration and are largely driven by knowledge gaps regarding propagation of the 75+ thornforest species planted during restorations. We previously investigated three thornforest species with low or inconsistent germination or seedling survival: Ebenopsis ebano (Fabaceae), Cordia boissieri (Boraginaceae), and Zanthoxylum fagara (Rutaceae), and identified the types and dosages of chemical seed treatments that maximized germination. However, chemical treatments were performed in isolation and combinational treatments may be required to break dormancy or maximize germination. This study builds on prior work by investigating …

Connecting And Communicating To Support Youth Mental Health, Michele Davide

Seton Hall University Dissertations and Theses (ETDs)

The nation is experiencing a pediatric mental health crisis amid a shortage of pediatric mental health care providers. The Connecting and Communicating project explores a strategy pediatric primary care practitioners can employ to bridge this gap and maximize their impact on supporting youth mental health in a community.

For this project, a pediatric primary care nurse practitioner created a pilot educational video with the dual purpose of educating parents and school staff on the importance of connecting with adolescents using the proven evidence supported communication technique of validating strong emotions without judgement, and partnering with pediatric health stakeholders by requesting …

Measurement Of Severe Acute Respiratory Syndrome Coronavirus 2 Antigens In Plasma Of Pediatric Patients With Acute Coronavirus Disease 2019 Or Multisystem Inflammatory Syndrome In Children Using An Ultrasensitive And Quantitative Immunoassay, George B Sigal, Tanya Novak, Anu Mathew, Janet Chou, Yubo Zhang, Navaratnam Manjula, Pradeepthi Bathala, Jessica Joe, Nikhil Padmanabhan, Daniel Romero, Gabriella Allegri-Machado, Jill Joerger, Laura L Loftis, Stephanie P Schwartz, Tracie C Walker, Julie C Fitzgerald, Keiko M Tarquinio, Matt S Zinter, Jennifer E Schuster, Natasha B Halasa, Melissa L Cullimore, Aline B Maddux, Mary A Staat, Katherine Irby, Heidi R Flori, Bria M Coates, Hillary Crandall, Shira J Gertz, Adrienne G Randolph, Nira R Pollock, Overcoming Covid-19 Investigators

Center for Medical Ethics and Health Policy Staff Publications

Background: Detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigens in blood has high sensitivity in adults with acute coronavirus disease 2019 (COVID-19), but sensitivity in pediatric patients is unclear. Recent data suggest that persistent SARS-CoV-2 spike antigenemia may contribute to multisystem inflammatory syndrome in children (MIS-C). We quantified SARS-CoV-2 nucleocapsid (N) and spike (S) antigens in blood of pediatric patients with either acute COVID-19 or MIS-C using ultrasensitive immunoassays (Meso Scale Discovery).

Methods: Plasma was collected from inpatients (< 21 years) enrolled across 15 hospitals in 15 US states. Acute COVID-19 patients (n = 36) had a range of disease severity and positive nasopharyngeal SARS-CoV-2 RT-PCR within 24 hours of blood collection. Patients with MIS-C (n = 53) met CDC criteria and tested positive for SARS-CoV-2 (RT-PCR or serology). Controls were patients pre-COVID-19 (n = 67) or within 24 hours of negative RT-PCR (n = 43).

Results: Specificities of N and S assays were 95-97% and 100%, respectively. In acute COVID-19 patients, N/S plasma assays …

Smart And Multi-Functional Magnetic Nanoparticles For Cancer Treatment Applications: Clinical Challenges And Future Prospects, Elham Aram, Masome Moeni, Roya Abedizadeh, Davood Sabour, Hamid Sadeghi-Abandansari, Jabbar Gardy, Ali Hassanpour

Faculty, Staff and Students Publications

Iron oxide nanoparticle (IONPs) have become a subject of interest in various biomedical fields due to their magnetism and biocompatibility. They can be utilized as heat mediators in magnetic hyperthermia (MHT) or as contrast media in magnetic resonance imaging (MRI), and ultrasound (US). In addition, their high drug-loading capacity enabled them to be therapeutic agent transporters for malignancy treatment. Hence, smartening them allows for an intelligent controlled drug release (CDR) and targeted drug delivery (TDD). Smart magnetic nanoparticles (SMNPs) can overcome the impediments faced by classical chemo-treatment strategies, since they can be navigated and release drug via external or internal …

Full Issue

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

No abstract provided.

Byu Anthropologist Addresses Maya Origins Puzzle

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

In 2001 the chance discovery of a 2,000-year-old Maya mural in a chamber buried beneath a pyramid in the Guatemalan jungle stirred the archaeological community. It was a sensational find, one of the most important for Mayanists in half a century. Rendered in brilliant colors with exquisite skill, the remarkably well-preserved mural reveals a highly sophisticated artistic tradition and hieroglyphic script predating the Maya’s golden age by 800 years.

Executive Committee - Minutes, 10/11/2022, Academic Senate

Academic Senate Minutes

No abstract provided.

University Of Mississippi Botanical Dietary Supplements Research Center, Iklas A. Khan, Nirmal D. Pugh, Amar G. Chittiboyina, Chalet Tan, Gailen D. Marshall, M. Khalid Ashfaq, Shabana I. Khan

Annual Poster Session 2022

Department/Unit poster (NCNPR). Corresponding author: Nirmal Pugh ([email protected])

Tuning The Structural Properties Of Cellulose Acetate Thin Films: A Demonstration Of Confinement And Antiplasticization In Cellulose Acetate Butyrate, Keegan Reece Parkhurst

Graduate Theses - Chemical Engineering

The development of high-performance cellulose acetate thin-film composite membranes will be essential to solving the growing water scarcity problems. To do this, understanding the fundamental structure of thin cellulosic films and its relation to transport is essential. In this work, thin cellulose acetate butyrate films were fabricated at varying thickness and treatments, such as soaking and plasticizer treatment. Their mechanical properties were analyzed using a surface wrinkling approach, and their hygroscopic properties were measured using swelling measurements and surface wrinkling under humid conditions. This work demonstrates confinement in cellulose acetate butyrate films at thicknesses below 45 to 70 nanometers. Plasticization …

Neo-Clerodanes From Teucrium Divaricatum And Their Potential Antiinflammatory And Antimicrobial Activities, Sophie Fadime Aydoğan, Zulfiqar Ali, Shabana I. Khan, Canan Karaalp, Ikhlas A. Khan, Erdal Bedir

Annual Poster Session 2022

Corresponding author (NCNPR): Fadime Aydoğan, [email protected]

Does Vdac2 Have A Bh3 Domain For Binding Bax?, Lillian Ferkany, Claire Pearson, Mika B. Jekabsons

Annual Poster Session 2022

Corresponding author (Biology): Lilian Ferkany, [email protected]

Programs Agenda October 11, 2022, Angela Brock

Programs Committee (PC)

No abstract provided.