Digital Commons Network^™

Radiologist Versus Non-Radiologist Detection Of Lymph Node Metastasis In Papillary Thyroid Carcinoma By Ultrasound: A Meta-Analysis, Peter P. Issa, Lauren Mueller, Mohammad Hussein, Aaron Albuck, Mohamed Shama, Eman Toraih, Emad Kandil

School of Medicine Faculty Publications

Papillary thyroid carcinoma (PTC) is the most common thyroid cancer worldwide and is known to spread to adjacent neck lymphatics. Lymph node metastasis (LNM) is a known predictor of disease recurrence and is an indicator for aggressive resection. Our study aims to determine if ultrasound sonographers’ degree of training influences overall LNM detection. PubMed, Embase, and Scopus articles were searched and screened for relevant articles. Two investigators independently screened and extracted the data. Diagnostic test parameters were determined for all studies, studies reported by radiologists, and studies reported by non-radiologists. The total sample size amounted to 5768 patients and 10,030 …

The Diamond, October 14, 2022, Dordt University

Dordt Diamond

• Front Page: Hispanic Heritage at Dordt and Beyond; Increasing Need for More ESL Staff at Local Schools; Accreditation: What Does It Mean to You?
• News: Southview Apartment Catches Fire; Dordt Professor Starts Disc Golf League; Dordt Hosts Fitness Week for Community
• Feature: Ag-Ed Majors Earn Honors; Local Libraries' Addiction Series Wraps Up; Holland Flower Farm; Full Circle: David Lee Returns to Dordt; The Burden of Back Pain; Student Employment Understaffed
• Opinion: Dahmer Controversy; A Story of a Ukrainian Refugee
• Art & Entertainment: You Should be Worried, Darling; Theatre Arts Prepares "Our Town"; Football Players When …

Long-Term Persistence Of Desert Rodent Species In A Great Basin Sagebrush Community: Potential Effects Of Fire, Invasive Annuals, And Warming Temperatures, Lindsay A. Dimitri, William S. Longland

Western North American Naturalist

To test long-term stability of a desert rodent community and potential impacts of wildfire on the community’s stability, we live-trapped desert rodents from 2019 to 2021 at a site in western Nevada where we had previously trapped from 1989 to 1993. Trapping occurred in unburned sagebrush (Artemisia tridentata) and in adjacent burned habitat where sagebrush cover was removed by a fire in 1985. We also used online data to test for trends in estimated cover of annual and perennial vegetation and in ambient temperatures and precipitation over the >30-year period spanned by the trapping data. White-tailed antelope squirrels …

Pluralistic Professionalisms: Religious Identity, Excluded Voice, And A Toolkit For The Periphery, Swethaa S. Ballakrishnen

Texas A&M Law Review

Assimilation of new entrants into the legal profession has been a signature strain of Carrie Menkel-Meadow’s research. Even if the empirical particularities have since evolved, her pathbreaking research on women lawyers and gendered lawyering processes remain prime examples of socio-legal work on lawyers with important theoretical extensions. For example, in Portia in a Different Voice, her now classic piece from 1985, Menkel-Meadow analyzes how numbers alone are insufficient indicia of feminization within the legal profession. Beyond the description of the state of the legal profession at the time of writing, her argument that we should pay attention to what lawyers …

Ethical Negotiation And Postcapitalist Politics: An Essay For Carrie, Amy J. Cohen

Texas A&M Law Review

In a 1983 article, Legal Negotiation: A Study of Strategies in Search of a Theory, Carrie Menkel-Meadow took stock of what was motivating a diverse range of scholars to want to reimagine negotiation theory. She described these negotiation scholars as shaped by the exigencies of their own political moments. Some were lawyers concerned about too much litigation of an unsatisfying quality. Many, however, were concerned more broadly about “the general level of hostility in the world,” even haunted by the possibility that nuclear weapons could destroy all of humanity. Negotiation scholars included “[e]conomists and game theorists . . . concerned …

Carrie Menkel-Meadow: Dispute Resolution In A Feminist Voice, Andrea Kupfer Schneider

Texas A&M Law Review

The presence of women in the law has changed the law’s substance, practice, and process. Carrie Menkel-Meadow, whose scholarship centers on this theme, is one such revolutionary woman.

Professor Menkel-Meadow, who I am proud to call my colleague, co-author, and friend (hereinafter referred to as Carrie), began her career in 1977 with a series of simple questions that sparked a breathtaking body of work. Carrie probed the depth of male domination in the realm of law and wondered what changes female representation might engender. In particular, she focused her inquiry on the value orientation each respective gender might bring to …

Machine Learning On Syngeneic Mouse Tumor Profiles To Model Clinical Immunotherapy Response, Zexian Zeng, Shengqing Stan Gu, Cheryl J Wong, Lin Yang, Nofal Ouardaoui, Dian Li, Wubing Zhang, Myles Brown, X Shirley Liu

Faculty, Staff and Student Publications

Most patients with cancer are refractory to immune checkpoint blockade (ICB) therapy, and proper patient stratification remains an open question. Primary patient data suffer from high heterogeneity, low accessibility, and lack of proper controls. In contrast, syngeneic mouse tumor models enable controlled experiments with ICB treatments. Using transcriptomic and experimental variables from >700 ICB-treated/control syngeneic mouse tumors, we developed a machine learning framework to model tumor immunity and identify factors influencing ICB response. Projected on human immunotherapy trial data, we found that the model can predict clinical ICB response. We further applied the model to predicting ICB-responsive/resistant cancer types in …

Bee‑Safe Peptidomimetic Acaricides Achieved By Comparative Genomics, Vikas Jindal, Daqi Li, Leslie Catherine Rault, Soheila Fatehi, Rupinder Singh, Moritz Mating, Ye Zou, Ho‑Leung Ng, Krzysztof Kaczmarek, Janusz Zabrocki, Shunhua Gui, Guy Smagghe, Troy D. Anderson, Ronald J. Nachman, Yoonseong Park

Department of Entomology: Faculty Publications

The devastating Varroa mite (Varroa destructor Anderson and Trueman) is an obligatory ectoparasite of the honey bee, contributing to significant colony losses in North America and throughout the world. The limited number of conventional acaricides to reduce Varroa mites and prevent disease in honey bee colonies is challenged with wide-spread resistance and low target-site selectivity. Here, we propose a biorational approach using comparative genomics for the development of honey beesafe and selective acaricides targeting the Varroa mite-specific neuropeptidergic system regulated by proctolin, which is lacking in the honey bee. Proctolin is a highly conserved pentapeptide RYLPT (Arg-Tyr-Leu-Pro-Thr) known to …

Hybrid Timber Concrete Composite Slab For Analysis Of Lag Screw Embedment Connections, Jawad Al Lawati, Ece Erdogmus, Dennis Young, Husam Al Dughaishi, Moad Alosta, Zainab Al-Khafaji, Zaher Mundher Yaseen, Abdalrhman Milad

Department of Civil and Environmental Engineering: Faculty Publications

Push-out-shear tests were used in this study to analyze lag screw connections in timber-concrete composite (TCC) slabs based on the embedment depth. The goal of this research is to look into the relationship between shear capacity and embedment depth in TCC, as well as to investigate the embedment strength of the wood. Experiments were carried out at different embedment depths (5.08 cm, 7.0 cm, and 8.9 cm). The prepared samples were examined in order to determine the failure modes and provide an accurate assessment of the influence of embedment depth on TCC slabs. The investigation on the embedment strength of …

Fresh Air For The Mire-Breathing Hypothesis: Sphagnum Moss And Peat Structure Regulate The Response Of Co2 Exchange To Altered Hydrology In A Northern Peatland Ecosystem, Ally O’Neill, Colin Tucker, Evan S. Kane

Michigan Tech Publications, Part 1

Sphagnum-dominated peatlands store more carbon than all of Earth’s forests, playing a large role in the balance of carbon dioxide. However, these carbon sinks face an uncertain future as the changing climate is likely to cause water stress, potentially reducing Sphagnum productivity and transitioning peatlands to carbon sources. A mesocosm experiment was performed on thirty-two peat cores collected from two peatland landforms: elevated mounds (hummocks) and lower, flat areas of the peatland (hollows). Both rainfall treatments and water tables were manipulated, and CO2 fluxes were measured. Other studies have observed peat subsiding and tracking the water table downward when experiencing …

Combined Trip13 And Aurora Kinase Inhibition Induces Apoptosis In Human Papillomavirus-Driven Cancers, Soma Ghosh, Tuhina Mazumdar, Wei Xu, Reid T Powell, Clifford Stephan, Li Shen, Pooja A Shah, Curtis R Pickering, Jeffery N Myers, Jing Wang, Mitchell J Frederick, Faye M Johnson

Faculty, Staff and Student Publications

PURPOSE: Human papillomavirus (HPV) causes >5% of cancers, but no therapies uniquely target HPV-driven cancers.

EXPERIMENTAL DESIGN: We tested the cytotoxic effect of 864 drugs in 16 HPV-positive and 17 HPV-negative human squamous cancer cell lines. We confirmed apoptosis in vitro and in vivo using patient-derived xenografts. Mitotic pathway components were manipulated with drugs, knockdown, and overexpression.

RESULTS: Aurora kinase inhibitors were more effective in vitro and in vivo in HPV-positive than in HPV-negative models. We hypothesized that the mechanism of sensitivity involves retinoblastoma (Rb) expression because the viral oncoprotein E7 leads to Rb protein degradation, and basal Rb protein …

Human Nop2/Nsun1 Regulates Ribosome Biogenesis Through Non-Catalytic Complex Formation With Box C/D Snornps, Han Liao, Anushri Gaur, Hunter Mcconie, Amirtha Shekar, Karen Wang, Jeffrey T Chang, Ghislain Breton, Catherine Denicourt

Faculty, Staff and Student Publications

5-Methylcytosine (m5C) is a base modification broadly found on various RNAs in the human transcriptome. In eukaryotes, m5C is catalyzed by enzymes of the NSUN family composed of seven human members (NSUN1-7). NOP2/NSUN1 has been primarily characterized in budding yeast as an essential ribosome biogenesis factor required for the deposition of m5C on the 25S ribosomal RNA (rRNA). Although human NOP2/NSUN1 has been known to be an oncogene overexpressed in several types of cancer, its functions and substrates remain poorly characterized. Here, we used a miCLIP-seq approach to identify human NOP2/NSUN1 RNA substrates. Our analysis revealed that NOP2/NSUN1 catalyzes the …

World Health Organization (Who) International Classification Of Functioning, Disability And Health (Icf) Core Set Development For Interstitial Lung Disease, Lesley Ann Saketkoo, Reuben Escorpizo, Janos Varga, Kevin John Keen, Kim Fligelstone, Surinder S. Birring, Helene Alexanderson, Henrik Pettersson, Humza Ahmad Chaudhry, Janet L. Poole, Malin Regardt, Daphne Lesage, Catherine Sarver, Joseph Lanario, Elisabetta Renzoni, Mary Beth Scholand, Matthew R. Lammi, Otylia Kowal-Bielecka, Oliver Distler, Tracy Frech, Lee Shapiro, Cecilia Varju, Elizabeth R. Volkmann, Elana J. Bernstein, Marjolein Drent, Ogugua Ndili Obi, Karen C. Patterson, Anne Marie Russell

More Faculty of Health Research

Background: The World Health Organization (WHO) introduced the International Classification of Functioning, Disability, and Health (ICF) as a scientific method of disability data collection comprised of >1,200 categories describing the spectrum of impairment types (functional, symptoms-based and anatomical) under the bio-psycho-social model with consideration of environmental and personal factors (pf). ICF Core Sets and ICF Checklists are streamlined disease-specific resources for clinical use, service provision, and for use in health economics and health policy. ICF can disclose strengths and weaknesses across multiple patient-reported outcome measures (PROMs) and help consolidate best-fitting question-items from multiple PROMs. Interstitial lung diseases (ILDs), are generally …

Two Cases Of Autoimmune Syndrome Induced By Adjuvants (Asia): A Multifaceted Condition Calling For A Multidisciplinary Approach, Christine Loftis, Aidee C. Nunez, Mauricio De La Garza, Emilia C. Dulgheru

School of Medicine Publications

Silicone implants have been used for cosmetic enhancement and reconstructive purposes for over 60 years. Despite assiduous efforts to ensure safety, there is continuous evidence that they are not as biologically inert as previously postulated. We present two cases of autoimmune syndrome induced by adjuvants (ASIA) in Hispanic women. The first patient developed biopsy-proven immune-mediated necrotizing myopathy that was successfully treated with the combination of silicone explantation along with immunosuppressive therapy. Findings after implant removal demonstrated rupture and leakage of silicone from gluteal implants. The second patient developed autoimmune hemolytic anemia in the setting of a ruptured silicone breast implant. …

Full Issue, Winthrop Mcnair Research Bulletin

The Winthrop McNair Research Bulletin

Winthrop McNair Research Bulletin Volume 5, Full Issue

The Relationship Between Nature Connectedness And Physical Activity Patterns In A Sample Of Collegiate Students, Faculty, And Staff, Destinee Waddy

The Winthrop McNair Research Bulletin

PURPOSE: A strong relationship exists between physical activity (PA) and nature connectedness (NC); the most physically active individuals may also be the most nature connected. Designing PA programs and modifying college campuses through the lens of biophilia can provide a more logical, evidence-based approach to improve overall health and wellness. The purpose of this study was to identify the relationship between physical activity and nature connectedness in a sample of collegiate faculty and students. METHODS: Participants completed two previously validated surveys: The International Physical Activity Questionnaire and the Connectedness to Nature Survey. Demographic data (age, race, campus affiliation) were also …

Locating Mutagen-Sensitivity Gene Mus109 In The Drosophila Melanogaster Genome Using Deficiency Mapping, Chandani Mitchell

The Winthrop McNair Research Bulletin

The complex processes involved in repairing damaged DNA are still being elucidated. Some genes that are known to have roles in the DNA repair process have been identified, such as the mutagen-sensitivity genes, or mus genes, in Drosophila melanogaster. However, the precise genomic location of some mus genes is still unknown, including mus109. It is known that mutations in mus109 cause chromosomal aberrations resulting in larval death, and previous research has mapped mus109 to a region of the X chromosome consisting of over 520,000 nucleotides and 41 genes. Therefore, this study aimed to locate mus109 using deficiency mapping. The mus109D2 …

The Impact Of Generalized Anxiety Disorder On Academic Performance In Undergraduate Students Following A Brief Guided Meditation, Ali Maclay

The Winthrop McNair Research Bulletin

Many undergraduate college students report high levels of anxiety, which can negatively impact their academic performance. Meditation is currently being explored as a method to reduce anxiety, with the duration and frequency under investigation to optimize outcomes. Therefore, this pilot study examined whether the severity of generalized anxiety disorder affected the influence of a brief, one-time, guided meditation on undergraduate academic performance. This study also investigated student perceptions of meditation and test anxiety. Students completed the GAD-7 to assess levels of anxiety, participated in a brief meditation, completed a lab quiz, and evaluated their meditation experience through a post-survey. We …

Invisible Barriers: Experiences Of First-Generation College Students Navigating Academia, Frances "Ana" Barkley

The Winthrop McNair Research Bulletin

Twenty-four percent of undergraduates in the US are considered first-generation and low-income (Engle & Tinto, 2008), while TRiO student support services serve less than 5% of these students (Mortenson, 2011). Previous research reveals that these students are less prepared for collegiate-level academic rigor, have fewer financial resources, and have less cultural and social capital compared to their non-first-generation and non-low-income peers (Engle & Tinto, 2008; Chen & Carroll, 2005; Engle, 2007, Willet 1989). Based on their testimonies, are there specific challenges that first-generation, low-income students are currently experiencing while navigating higher education in 2018? How can these testimonies inform the …

Cover, Winthrop Mcnair Research Bulletin

The Winthrop McNair Research Bulletin

Winthrop McNair Research Bulletin Volume 5, Cover

Expanding The Landscape Of Wholeness: The Spirituality Of Teacher Preparation. A Response To "Reconstituting Teacher Education: Toward Wholeness In An Era Of Monumental Challenges", Paul A. Michalec

Democracy & Education

This article is a response to a paper arguing for a shift from “oneness” to “wholeness” as a democratic principle when reconceptualizing teacher education in a time of large-scale social change. While the paper provides compelling arguments for wholeness as a tool to address social injustice, the discussion is framed primarily through a humanist lens. This response is an invitation to expand the definition of wholeness to include spirituality as core to what it means to be human and whole. It addresses the importance of spirituality in teacher education when considering culturally responsive pedagogy, the religion-spirit distinction, the source of …

About The Authors

Locus: The Seton Hall Journal of Undergraduate Research

Brief bios of our authors.

Ronald Dworkin’S Theory Of Adjudication As Applied To Obergefell V. Hodges, Miller Schulman

Locus: The Seton Hall Journal of Undergraduate Research

Obergefell v. Hodges decided in 2015 was a landmark case that answered two questions: (i) does the Fourteenth Amendment require a state to license a marriage between two people of the same sex, and (ii) does the Fourteenth Amendment require a state to recognize a marriage between two people of the same sex that was legally licensed and performed in another state (Obergefell v. Hodges)? In a 5-4 decision, the Supreme Court answered both questions in the affirmative. Particularly relevant to the majority’s reasoning in deciding this case is Ronald Dworkin’s theory on judicial decisions from Hard Cases, a …

Comparison Of The Effect Of Aerobic And Resistance Exercise On Short Term Memory On Healthy Adults, Frederick P. Wijaya, Ery Hermawati M.Sc, Willy Handoko M.Biomed

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

Background: Exercise is known to improve the cognitive function, including short-term memory. Exercise can induce structural and functional changes of the brain, i.e. synaptic plasticity. Exercise is categorized into two groups: aerobic exercise and resistance exercise. Studies have shown that both groups of exercises can improve short-term memory function.

Objectives: this research is aimed to compare the effect of aerobic and resistance exercise on short-term memory on healthy adults.

Methods: Participants were given the choice to be admitted into either exercise group, aerobic or resistance. Short-term memory (forward digit span) were measured before and after the intervention.

Results: there were …

Perceptions Of Earth Science Using Assistive And Supportive Technologies By Students Who Are Blind Or Visually Impaired, Rhea G. Miles, Alana Zambone, Alex Manda

Journal of Science Education for Students with Disabilities

Students with blindness or visual impairments (BVI) need to participate in scientific laboratory experiences at the K12 level to be successful in college-level science courses. These K12 level students need instruction to actively conduct science experiments and not only allow sighted students to conduct them. While it may be a challenge, with appropriate assistive and supportive technologies, students with BVI can be successful in conducting scientific investigations to address Next Generation Science Standards. The Discoveries in Earth Science (DES) program provides engaging accommodations adaptive to the needs of elementary, middle, and high school grade students with BVI to successfully prepare …

Whom Does Psychology Serve_ Neocolonialism In Peruvian Psychology, Yassira Armero, Andrés Costilla, Josephine Hwang

Psychology from the Margins

This article presents a review of the colonial past that has marked Peruvian society and has managed to remain in it through the neocolonialism. The purpose of this article is to account for how instrumental political use of psychology, and sometimes psychiatry, has been and continues to be used to favor the people who exercise power and to perpetuation the current system. For this, some examples of how this work has been carried out are described. Specifically, mention is made of how "ethnic hierarchies" were supported with the eugenic model, the "normal" was up justifying the subjugation of the indigenous …

Liberation Psychology: Drawing On History To Work Toward Resistance And Collective Healing In The United States, Hannah K. Heitz

Psychology from the Margins

With the onset of the Covid-19 pandemic and increased media coverage of systemic racism, the necessity to work toward liberation and collective healing has become increasingly salient. While psychology has prided itself on being ahistorical in the past, there is much that can be learned from scholars, activists, and movements that have fostered positive change. Ignacio Martín-Baró, Spanish-born Jesuit scholar, social psychologist, and founder of liberation psychology, worked toward significant positive social change and liberation prior to his death. In one of his last interviews, Martín-Baró outlined tasks that could be used to facilitate liberation: 1) recovering historical memory; 2) …

Dsm Discrimination And The Lgbt Community: Using The History Of Diagnostic Discrimination Against Sexual Minorities To Contextualize Current Issues In Transgender And Gender Diverse Mental Healthcare, Ginelle Wolfe, Nicole Fogwell

Psychology from the Margins

This paper provides a historical context of diagnoses in the Diagnostic and Statistical Manual of Mental Disorders (DSM) related to sexual orientation and gender identity. We use the historical context of psychology’s discrimination against sexual minorities (e.g., lesbian, gay, and bisexual persons) to critique current discriminatory practices targeting gender diverse (i.e., trans, nonbinary, and other not cisgender) persons- specifically, the explicit pathologizing of gender variance. The events that led to the removal of homosexuality as a diagnosis are discussed, as are subsequent diagnoses related to sexual orientation and gender identity that continue to pathologize gender variance. We conclude by deriving …

The Chanticleer, 2022-10-13, Coastal Carolina University

The Chanticleer Student Newspaper

The editorially independent student produced weekly newspaper of Coastal Carolina University.

Medical School Watercooler Newsletter - October 13, 2022, Lindsey Lyle

Watercooler Newsletter

This is the October 13, 2022 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents include:

• Student-Run Free Clinic to offer free flu shots
• Arrieta named interim director of USA Center for Healthy Communities
• Surgery faculty discuss laser therapy for burns at national burn conference
• Leavesley to present on hyperspectral imaging for tissue diagnosis
• Interventional neurologist joins neurology faculty
• Meet a Med Student: Madison Hogans