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Data Driven Classification Of Opioid Patients Using Machine Learning - An Investigation, Saddam Al Amin, Md Saddam Hossain Mukta, Md Sezan Mahmud Saikat, Md Ismail Hossain, Md Adnanul Islam, Mohiuddin Ahmed, Sami Azam

Research outputs 2022 to 2026

The opioid crisis has led to an increased number of drug overdoses in recent years. Several approaches have been established to predict opioid prescription by health practitioners. However, due to the complex nature of the problem, the accuracy of such methods is not yet satisfactory. Dependable and reliable classification of opioid dependent patients from well-grounded data sources is essential. Majority of the previous studies do not focus on the users’ mental health association for opioid intake classification. These studies do not also employ the latest deep learning based techniques such as attention and knowledge distillation mechanism to find better insights. …

Antibody Epitope Profiling Of The Kshv Lana Protein Using Virscan, Sydney J. Bennett, Dicle Yalcin, Sara R. Privatt, Owen Ngalamika, Salum J. Lidenge, John T. West, Charles Wood

School of Medicine Faculty Publications

The humoral antibody response against Kaposi sarcoma-associated herpesvirus (KSHV) in infected individuals has been characterized demonstrating the latency-associated nuclear antigen (LANA) as the most antigenic KSHV protein. Despite the antigenicity of the protein, specific LANA epitopes have not been systematically characterized. Here, we utilized a bacteriophage T7 library, which displays 56-amino acid KSHV LANA peptides with 28-amino acid overlap (VirScan), to define those epitopes in LANA targeted by antibodies from a cohort of 62 sub-Saharan African Kaposi Sarcoma (KS) patients and 22 KSHV-infected asymptomatic controls. Intra- and inter-patient breadth and magnitude of the anti-LANA responses were quantified at the peptide …

Population Genomics Provide Insights Into The Global Genetic Structure Of Colletotrichum Graminicola, The Causal Agent Of Maize Anthracnose, Flávia Rogério, Riccardo Baroncelli, Francisco Borja Cuevas-Fernández, Sioly Becerra, Joanne Crouch, Wagner Bettiol, M. Andrea Azcárate-Peril, Martha Malapi-Wight, Veronique Ortega, Javier Betran, Albert Tenuta, José S. Dambolena, Paul D. Esker, Pedro Revilla, Tamra A. Jackson-Ziems, Jürg Hiltbrunner, Gary Munkvold, Ivica Buhiniček, José L. Vicente-Villardón, Serenella A. Sukno, Michael R. Thon

Department of Plant Pathology: Faculty Publications

Understanding the genetic diversity and mechanisms underlying genetic variation in pathogen populations is crucial to the development of effective control strategies. We investigated the genetic diversity and reproductive biology of Colletotrichum graminicola isolates which infect maize by sequencing the genomes of 108 isolates collected from 14 countries using restriction site-associated DNA sequencing (RAD-seq) and wholegenome sequencing (WGS). Clustering analyses based on single-nucleotide polymorphisms revealed three genetic groups delimited by continental origin, compatible with short-dispersal of the pathogen and geographic subdivision. Intra- and intercontinental migration was observed between Europe and South America, likely associated with the movement of contaminated germplasm. Low …

Implementation Of The Generalized Anxiety Disorder 7-Item (Gad-7) Screening Tool In A Mental Health Outpatient Clinic, Ella Bosunglan Gang

Doctoral Dissertations and Projects

Purpose: The prevalent disorder known as generalized anxiety disorder (GAD) can have various negative consequences. GAD harms individuals, families, communities, and society as a whole. People with GAD frequently experience a crippling decrease in their physical and mental health. When generalized anxiety disorders are combined with the pressures of pre-existing medical conditions, the quality of life can be significantly impacted. GAD severely impairs social and functional functioning, resulting in frequent clinic appointments, doctor shopping, emergency room visits, high costs from family and employer treatment, and increased costs for global healthcare spending. Proper diagnosis is essential to effective treatment, and a …

The Impact Of Covid-19 On The Mental Health Well-Being Among Staff Of A Domestic Violence Shelter, Tonisia Lynette Brown-Cotten

Doctoral Dissertations and Projects

The purpose of this qualitatively study via the Case Study approach was to recognize the impact that coronavirus disease-2019 (COVID-19) had on the mental health of randomly selected female domestic violence shelters’ board members, staff, volunteers, and counselors and therapists. To guide this study, the theory of integrating existing knowledge of a topic generated an in-depth, multi-faceted understanding of a complex issue. The case study aimed to answer how COVID-19 impacted higher levels of stress, depression, anxiety, and post-traumatic stress symptoms in the female gender. The study focused on the experiences of vicarious trauma (VT), secondary traumatic stress (STT), compassion …

A Phenomenological Study On Church Leaders' Perspective Of Internet Church As A Biblical Community, Jason Lavon Rankin

Doctoral Dissertations and Projects

Current events and relatively recent technological developments have caused and significantly increased the use of digital technology in most aspects of life. The digital revolution, as some have termed it, has permeated all organizations, from businesses to institutions of higher learning, including religious institutions. The purpose of this phenomenological study was to determine Christian church leaders’ perspectives on whether the internet church fulfills the biblical and theological definitions of the church or biblical community. At this stage in the research internet church, also known as online church, e-church, virtual church, etc., is defined as a group of people with shared …

It’S The Trauma Talking: A Phenomenology Of Foster Parents’ Trauma Knowledge In Central Virginia, Stephanie Lynn Cheek

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to describe foster parents’ trauma knowledge in Central Virginia. The theories guiding this study include childhood complex trauma theory and experiential learning theory (ELT). As discussed by Herman (1992) and Terr (1991), childhood complex trauma theory explains the behaviors and actions of foster children who have suffered complex trauma. As discussed by Kolb (2014), ELT explains the processes that foster parents go through in gaining and applying trauma knowledge to their fostering. The central research question is, how do foster parents in Central Virginia describe their trauma knowledge? Further research questions include, how …

The Importance Of Pediatric Provider Awareness Of Social Determinants Of Health And The Impact On Health Outcomes: An Integrative Review, Whitney Lenelle Dowd

Doctoral Dissertations and Projects

Social determinants of health have become a global concern over the past several years. Efforts to reduce negative health outcomes related to social determinants of health are of high priority. Awareness of this issue by providers, especially pediatric providers, must be considered to help combat this major concern. A researcher seeks through an integrative review to determine provider perspective on social determinants of health, impact of social determinants of health on outcomes, and ways of integrating social determinants into prescriptive practice. The integrative review will inform stakeholders about the importance of pediatric provider assessment of social determinants of health and …

A Causal-Comparative Study Of The Impact Of Meaningful Watershed Environmental Experiences On The Academic Achievement Of Middle School Students, Gina R. Mason

Doctoral Dissertations and Projects

Meaningful watershed educational experiences (MWEE) are student-centered, problem solving-oriented environmental educational experiences in which students investigate local environmental issues leading to civic engagement and informed action. The four components of an MWEE include issue definition, outdoor field experience, synthesis and conclusion, and action projects. While multiple benefits have been shown to be gained through participation in environmental education, this study’s aim was to observe the impact MWEEs have on academic achievement in middle school students. This quantitative, ex post facto, causal-comparative study examined the impact MWEEs had on students’ achievement scores, as measured by Pennsylvania System of School Assessment (PSSA) …

Research Gaps And Opportunities In Precision Nutrition: An Nih Workshop Report, Bruce Y. Lee, José M. Ordovás, Elizabeth J. Parks, Cheryl A.M. Anderson, Albert László Barabási, Steven K. Clinton, Kayla De La Haye, Valerie B. Duffy, Paul W. Franks, Elizabeth M. Ginexi, Kristian J. Hammond, Erin C. Hanlon, Michael Hittle, Emily Ho, Abigail L. Horn, Richard S. Isaacson, Patricia L. Mabry, Susan Malone, Corby K. Martin, Josiemer Mattei, Simin Nikbin Meydani, Lorene M. Nelson, Marian L. Neuhouser, Brendan Parent, Nicolaas P. Pronk, Helen M. Roche, Suchi Saria, Frank A.J.L. Scheer, Eran Segal, Mary Ann Sevick, Tim D. Spector, Linda Van Horn, Krista A. Varady, Venkata Saroja Voruganti

Clinical Research Faculty Publications

Precision nutrition is an emerging concept that aims to develop nutrition recommendations tailored to different people's circumstances and biological characteristics. Responses to dietary change and the resulting health outcomes from consuming different diets may vary significantly between people based on interactions between their genetic backgrounds, physiology, microbiome, underlying health status, behaviors, social influences, and environmental exposures. On 11-12 January 2021, the National Institutes of Health convened a workshop entitled "Precision Nutrition: Research Gaps and Opportunities" to bring together experts to discuss the issues involved in better understanding and addressing precision nutrition. The workshop proceeded in 3 parts: part I covered …

Cenozoic Extension Of The Lake Tanganyika Rift, East Africa: Structures, Tectonostratigraphy And Paleoenvironmental Reconstruction, Shaidu Shaban

Dissertations - ALL

Active continental rifts are ideal sites for understanding the break-up of continents, and long-lived rift lake environments are known as important reservoirs for endemic communities and biodiversity. The sedimentary fill of extensional continental rifts within the East Africa Rift System (EARS) records a long history of continental extension and variable tropical climate that is unparalleled in its duration and fidelity. Continental extensional basins are sensitive to variations caused by the interplay between tectonics, sedimentary processes, and climate change. However, to discern the sedimentary fill history and its related tectonostratigraphy, as well as for reconstructing past climate changes, high-fidelity data such …

A Coherence-Colored Look Inside Reverse Micelles: Advancing Magnetic Resonance Relaxometry To Characterize Internal Water Pool Dynamics, Alec Beaton

Dissertations - ALL

Traditional data acquisition methods in Nuclear Magnetic Resonance (NMR) collect a subset of the total amount of generated data and discard the rest. In this work, a modified approach toward NMR data acquisition and analysis is formalized and applied in a series of different contexts, ultimately illustrating the utility of collecting and considering this traditionally discarded data. In particular, it is shown that this approach both facilitates and improves NMR data acquisition capabilities at low field (15 MHz), enabling one to overcome challenges arising from, for example, fluctuations in the static magnetic field.With these developments in hand, the dual resonance …

Arginine Methylation Of The Pgc-1Α C‑Terminus Is Temperature- Dependent, Meryl Mendoz, Mariel Mendoza, Tiffany Lubrino, Sidney Briski, Immaculeta Osuji, Janielle Cuala, Brendan Ly, Ivan Ocegueda, Harvey Peralta, Benjamin A. Garcia, Cecilia Zurita-Lopez

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

We set out to determine whether the C-terminus (amino acids 481–798) of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α, UniProt Q9UBK2), a regulatory metabolic protein involved in mitochondrial biogenesis, and respiration, is an arginine methyltransferase substrate. Arginine methylation by protein arginine methyltransferases (PRMTs) alters protein function and thus contributes to various cellular processes. In addition to confirming methylation of the C-terminus by PRMT1 as described in the literature, we have identified methylation by another member of the PRMT family, PRMT7. We performed in vitro methylation reactions using recombinant mammalian PRMT7 and PRMT1 at 37, 30, 21, 18, and 4 °C. …

A Non-Invasive Artificial Intelligence Approach For The Prediction Of Human Blastocyst Ploidy: A Retrospective Model Development And Validation Study, Josue Barnes, Matthew Brendel, Vianne R. Gao, Suraj Rajendran, Junbum Kim, Qianzi Li, Jonas E. Malmsten, Jose T. Sierra, Pantelis Zisimopoulos, Alexandros Sigaras, Pegah Khosravi, Marcos Meseguer, Qiansheng Zhan, Zev Rosenwaks, Olivier Elemento, Nikica Zaninovic, Iman Hajirasouliha

Publications and Research

Summary

Background

One challenge in the field of in-vitro fertilisation is the selection of the most viable embryos for transfer. Morphological quality assessment and morphokinetic analysis both have the disadvantage of intra-observer and inter-observer variability. A third method, preimplantation genetic testing for aneuploidy (PGT-A), has limitations too, including its invasiveness and cost. We hypothesised that differences in aneuploid and euploid embryos that allow for model-based classification are reflected in morphology, morphokinetics, and associated clinical information.

Methods

In this retrospective study, we used machine-learning and deep-learning approaches to develop STORK-A, a non-invasive and automated method of embryo evaluation that uses artificial …

Does The Anastatica Hierochuntica Plant Shorten The Duration Of Labour? A Prospective Observational Study, Filiz Okumuş, Halime Öncü-Çelik, Nevin Şahin

Journal of Asian Midwives (JAM)

Objective: This study aims to investigate the effect of Anastatica Hierochuntica L. on the duration of labour in primiparous women.
Methods: A prospective, case-controlled study with an intervention (n=28) and control (n=29) group. Participants were not randomized; their preferences related to the use of the A. Hierochuntica L. determined the group in which they would be included. In the intervention group, Anastatica Hierochuntica L. was used by all women. Standard care continued for both the intervention and control group. The duration of the first and second stage of labour were evaluated and compared between groups.
Results: Participants’ mean of age …

Scientific Pioneer' Named Joseph Sam Award Recipient, Natalie Ehrhardt

University of Mississippi News

Aaron Beeler talks photochemistry in award lecture

Prescribing A Change To The Fda's Drug Labeling Rules After The 21st Century Cures Act, P. Sydney Engle

Duke Law Journal

Signed into law in 2016, the 21st Century Cures Act offers new hope to patients by empowering the FDA to expedite review of innovative, potentially lifesaving drugs. But these expedited approvals raise the risk that pivotal drug safety and efficacy data will not arise until after the drug is already on the market. The Cures Act failed to respond to two key aspects of shifting the discovery of safety and efficacy data to the postmarket phase. First, the Cures Act did not correspondingly enhance the FDA’s authority to require manufacturers to generate and disclose postmarket information. Second, it did not …

Acquired And Useful Abilities: Three Essays On Human Capital Development, Rajan Bishwakarma

Economics ETDs

While early childhood circumstances influence the accumulation of skills and abilities, parental and policy responses can magnify or mitigate the effects of childhood circumstances. This work explores the two ideas mentioned above.

Chapter 1 briefs the historical and philosophical roots of the study of human capital and discusses the economic approach to the understanding of child wellbeing before the age of five. Because childhood circumstances influence the accumulation of skills, Chapter 2 estimates the impact of temperature shock during pregnancy on early childhood health. Evidence from Nepal shows that prenatal exposure to high-temperature days impedes child growth; however, the damage …

The Role Of Lncrnas In The Tumor Microenvironment And Immunotherapy Of Melanoma, Wencheng Zhou, Xuewen Xu, Ying Cen, Junjie Chen

Faculty, Staff and Student Publications

Melanoma is one of the most lethal tumors with highly aggressive and metastatic properties. Although immunotherapy and targeted therapy have certain therapeutic effects in melanoma, a significant proportion of patients still have drug resistance after treatment. Recent studies have shown that long noncoding RNAs (lncRNAs) are widely recognized as regulatory factors in cancer. They can regulate numerous cellular processes, including cell proliferation, metastasis, epithelial-mesenchymal transition (EMT) progression and the immune microenvironment. The role of lncRNAs in malignant tumors has received much attention, whereas the relationship between lncRNAs and melanoma requires further investigation. Our review summarizes tumor suppressive and oncogenic lncRNAs …

Accumulation Of Sublethal Radiation Damage And Its Effect On Cell Survival, Oleg N Vassiliev

Faculty, Staff and Student Publications

Objective. Determine the extent of sublethal radiation damage (SRD) in a cell population that received a given dose of radiation and the impact of this damage on cell survival. Approach. We developed a novel formalism to account for accumulation of SRD with increasing dose. It is based on a very general formula for cell survival that correctly predicts the basic properties of cell survival curves, such as the transition from the linear-quadratic to a linear dependence at high doses. Using this formalism we analyzed extensive experimental data for photons, protons and heavy ions to evaluate model parameters, quantify the extent …

Quantification Of Phosphatidylethanol In Whole Blood And Dried Blood Spots By Lc-Ms/Ms, Elizabeth Yulianto

Student Theses

Phosphatidylethanol (PEth) is an alcohol biomarker that provides a longer window of detection than direct alcohol measurement or other common alcohol metabolites, like ethyl glucuronide. PEth has become useful in assessing drinking history, such as for alcohol-withdrawal treatment, organ transplant settings or prenatal alcohol exposure determination. A method was developed and validated to quantify PEth 16:0/18:1 and 16:0/18:2 in whole blood and dried blood spots (DBS) by liquid chromatography tandem mass spectrometry (LC-MS/MS). The whole blood method was applied to 149 samples from pregnant women, elucidating possible prenatal alcohol exposure. Fifty μL whole blood and 12.7 mm whole punches from …

A Phenomenological Study Of Black Women In Leadership: Exploring The Lived Experiences Of Women In The Healthcare Field, Janice Tabatha Hill

Doctoral Dissertations and Projects

The purpose of this qualitative phenomenological study was to explore the lived experiences of Black women in leadership positions in the healthcare field. The study used an intersectional lens to illustrate how gender, race, class, and spirituality contributed to the systemic structures of oppression, bias, and discrimination, limiting ascension to positions of power and authority. The theoretical framework guiding this inquiry was the great man leadership theory, which analyzed how socio-cultural identities influenced Black women’s perceptions and experiences of leadership within the organizational context. Adopting a phenomenological study research design conceptualized the experiences of Black women executives working in a …

Droughts Reduce Growth Rates And Increase Vulnerability To Increasingly Frequent And Severe Drying Events In An Aquatic Ectotherm, Thomas M. Luhring, Lyndsie S. Wszola, Grant M. Connette, Christopher M. Schalk

School of Biological Sciences: Faculty Publications

Many aquatic organisms are experiencing increasingly severe and frequent droughts and drying events. Simultaneously, drought effects are carrying over to non-drought years as ecosystems remain in incomplete states of recovery. Aquatic organisms are thus faced with fewer sequential years under degraded environmental conditions to prepare for increasingly severe droughts and potential drying events. We assessed the effect of droughts and sex on the growth, mass, and mass-dependent estivation potential of long-lived aquatic salamanders (Greater Sirens, Siren lacertina) that estivate during drying events brought on by severe droughts. We calculated growth rates of S. lacertina based on mark–recapture data spanning …

Antibody Epitope Profiling Of The Kshv Lana Protein Using Virscan, Sydney J. Bennett, Dicle Yalcin, Sara R. Privatt, Owen Ngalamika, Salum J. Lidenge, John T. West, Charles Wood

School of Biological Sciences: Faculty Publications

The humoral antibody response against Kaposi sarcoma-associated herpesvirus (KSHV) in infected individuals has been characterized demonstrating the latency-associated nuclear antigen (LANA) as the most antigenic KSHV protein. Despite the antigenicity of the protein, specific LANA epitopes have not been systematically characterized. Here, we utilized a bacteriophage T7 library, which displays 56-amino acid KSHV LANA peptides with 28-amino acid overlap (VirScan), to define those epitopes in LANA targeted by antibodies from a cohort of 62 sub-Saharan African Kaposi sarcoma (KS) patients and 22 KSHV-infected asymptomatic controls. Intra- and inter-patient breadth and magnitude of the anti-LANA responses were quantified at the peptide …

Droughts Reduce Growth Rates And Increase Vulnerability To Increasingly Frequent And Severe Drying Events In An Aquatic Ectotherm, Thomas M. Luhring, Lyndsie S. Wszola, Grant M. Connette, Christopher M. Schalk

School of Biological Sciences: Faculty Publications

Many aquatic organisms are experiencing increasingly severe and frequent droughts and drying events. Simultaneously, drought effects are carrying over to nondrought years as ecosystems remain in incomplete states of recovery. Aquatic organisms are thus faced with fewer sequential years under degraded environmental conditions to prepare for increasingly severe droughts and potential drying events. We assessed the effect of droughts and sex on the growth, mass, and mass-dependent estivation potential of long-lived aquatic salamanders (Greater Sirens, Siren lacertina) that estivate during drying events brought on by severe droughts. We calculated growth rates of S. lacertina based on mark–recapture data spanning …

6k1, Nia-Vpg, Nia-Pro, And Cp Ofwheat Streak Mosaic Virus Are Collective Determinants Of Wheat Streak Mosaic Disease In Wheat, Satyanarayana Tatineni, Jeffrey Alexander, Haritha Nunna

Department of Plant Pathology: Faculty Publications

Wheat streak mosaic virus (WSMV; genus Tritimovirus, family Potyviridae) is the causal agent of the most economically important wheat streak mosaic disease of wheat (Triticum aestivum) in the Great Plains region of theUnited States.WSMVdeterminants responsible forwheat streak mosaic disease in wheat are unknown. Triticum mosaic virus (TriMV), a wheatinfecting virus,was used as an expression vector for the transient expression of each of the WSMV-encoded cistrons in wheat. WSMV-encoded 6K1, NIa-VPg, NIa-Pro, and CP cistrons in TriMV elicited symptoms specific to different stages of wheat streak mosaic disease without significantly affecting the genomic RNA accumulation. WSMV 6K1 …

Stabilization Of Mcl-1 By E3 Ligase Traf4 Confers Radioresistance, Ming Li, Feng Gao, Xiaoying Li, Yu Gan, Shuangze Han, Xinfang Yu, Haidan Liu, Wei Li

Faculty, Staff and Students Publications

The E3 ligase TNF receptor-associated factor 4 (TRAF4) is frequently overexpressed and closely related to poor prognosis in human malignancies. However, its effect on carcinogenesis and radiosensitivity in oral squamous cell carcinoma (OSCC) remains unclear. The present study found that TRAF4 was significantly upregulated in primary and relapsed OSCC tumor tissues. Depletion of TRAF4 markedly improved the sensitivity of OSCC cells to irradiation (IR) treatment, showing that tumor cell proliferation, colony formation and xenograft tumor growth were reduced. Mechanistically, IR promoted the interaction between TRAF4 and Akt to induce Akt K63-mediated ubiquitination and activation. TRAF4 knockout inhibited the phosphorylation of …

Association Of Chlorhexidine Use And Scaling And Root Planing With Birth Outcomes In Pregnant Individuals With Periodontitis: A Systematic Review And Meta-Analysis, Maxwell Akonde, Rajat Das Gupta, Maxwell Akonde, Mark Reynolds, Stephanie Smith-Warner, Jihong Liu Sc.D., Fouzia Tarannum, James Beck, Donald Mattison

Faculty Publications

Importance Chlorhexidine mouthwash enhances treatment effects of conventional periodontal treatment, but data on chlorhexidine as a source of heterogeneity in meta-analyses assessing the treatment of maternal periodontitis in association with birth outcomes are lacking.

Objective To assess possible heterogeneity by chlorhexidine use in randomized clinical trials (RCTs) evaluating the effect of periodontal treatment (ie, scaling and root planing [SRP]) vs no treatment on birth outcomes.

Data Sources Cochrane Oral Health’s Trials Register, Cochrane Pregnancy and Childbirth’s Trials Register, Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE Ovid, Embase Ovid, LILACS BIREME Virtual Health Library (Latin American and Caribbean Health Science …

Association Of Chlorhexidine Use And Scaling And Root Planing With Birth Outcomes In Pregnant Individuals With Periodontitis: A Systematic Review And Meta-Analysis, Anwar T. Nerchant, Rajat Das Gupta, Maxwell Akonde, Mark Reynolds, Stephanie Smith-Warner, Jihong Liu, Fouzia Tarannum, James Beck, Donald Mattison

Faculty Publications

Importance Chlorhexidine mouthwash enhances treatment effects of conventional periodontal treatment, but data on chlorhexidine as a source of heterogeneity in meta-analyses assessing the treatment of maternal periodontitis in association with birth outcomes are lacking.

Objective To assess possible heterogeneity by chlorhexidine use in randomized clinical trials (RCTs) evaluating the effect of periodontal treatment (ie, scaling and root planing [SRP]) vs no treatment on birth outcomes.

Data Sources Cochrane Oral Health’s Trials Register, Cochrane Pregnancy and Childbirth’s Trials Register, Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE Ovid, Embase Ovid, LILACS BIREME Virtual Health Library (Latin American and Caribbean Health Science …

Board Games: A Perfect Match For Reading Comprehension, Christopher Allen Frazier

Masters Theses

Analog board games greatly benefit students’ development and overall well-being. Board games offer opportunities for early learning, help boost language skills, sharpen students’ ability to focus, teach the value of teamwork, and soothe anxiety. Integrating board games with literacy skills allows students to assimilate information and develop into lifelong learners. Without solid literacy skills, the future is bleak for most students. To compound the problem, a trend today is to replace traditional board games as an educational tool with digital alternatives. This trend has seen a downward correlation with students having significant reading deficiencies in their reading comprehension in grades …