Digital Commons Network^™

The Equilibrium Of Tumor Suppression: Dubs As Active Regulators Of Pten, Audrey Christine, Mi Kyung Park, Su Jung Song, Min Sup Song

Faculty, Staff and Student Publications

PTEN is among the most commonly lost or mutated tumor suppressor genes in human cancer. PTEN, a bona fide lipid phosphatase that antagonizes the highly oncogenic PI3K-AKT-mTOR pathway, is considered a major dose-dependent tumor suppressor. Although PTEN function can be compromised by genetic mutations in inherited syndromes and cancers, posttranslational modifications of PTEN may also play key roles in the dynamic regulation of its function. Notably, deregulated ubiquitination and deubiquitination lead to detrimental impacts on PTEN levels and subcellular partitioning, promoting tumorigenesis. While PTEN can be targeted by HECT-type E3 ubiquitin ligases for nuclear import and proteasomal degradation, studies have …

Molecular Mechanisms Of Resistance To Kinase Inhibitors And Redifferentiation In Thyroid Cancers, Marie-Claude Hofmann, Muthusamy Kunnimalaiyaan, Jennifer R Wang, Naifa L Busaidy, Steven I Sherman, Stephen Y Lai, Mark Zafereo, Maria E Cabanillas

Faculty, Staff and Student Publications

Protein kinases play critical roles in cell survival, proliferation and motility. Their dysregulation is therefore a common feature in the pathogenesis of a number of solid tumors, including thyroid cancers. Inhibiting activated protein kinases has revolutionized thyroid cancer therapy, offering a promising strategy in treating tumors refractory to radioactive iodine treatment or cytotoxic chemotherapies. However, despite satisfactory early responses, these drugs are not curative and most patients inevitably progress due to drug resistance. This review summarizes up-to-date knowledge on various mechanisms that thyroid cancer cells develop to bypass protein kinase inhibition and outlines strategies that are being explored to overcome …

A Semi-Mechanistic Dose-Finding Design In Oncology Using Pharmacokinetic/Pharmacodynamic Modeling, Xiao Su, Yisheng Li, Peter Müller, Chia-Wei Hsu, Haitao Pan, Kim-Anh Do

Faculty, Staff and Student Publications

While a number of phase I dose-finding designs in oncology exist, the commonly used ones are either algorithmic or empirical model-based. We propose a new framework for modeling the dose-response relationship, by systematically incorporating the pharmacokinetic (PK) data collected in the trial and the hypothesized mechanisms of the drug effects, via dynamic PK/PD modeling, as well as modeling of the relationship between a latent cumulative pharmacologic effect and a binary toxicity outcome. This modeling framework naturally incorporates the information on the impact of dose, schedule and method of administration (e.g., drug formulation and route of administration) on toxicity. The resulting …

Molecular Map Of Chronic Lymphocytic Leukemia And Its Impact On Outcome, Binyamin A Knisbacher, Ziao Lin, Cynthia K Hahn, Ferran Nadeu, Martí Duran-Ferrer, Kristen E Stevenson, Eugen Tausch, Julio Delgado, Alex Barbera-Mourelle, Amaro Taylor-Weiner, Pablo Bousquets-Muñoz, Ander Diaz-Navarro, Andrew Dunford, Shankara Anand, Helene Kretzmer, Jesus Gutierrez-Abril, Sara López-Tamargo, Stacey M Fernandes, Clare Sun, Mariela Sivina, Laura Z Rassenti, Christof Schneider, Shuqiang Li, Laxmi Parida, Alexander Meissner, François Aguet, Jan A Burger, Adrian Wiestner, Thomas J Kipps, Jennifer R Brown, Michael Hallek, Chip Stewart, Donna S Neuberg, José I Martín-Subero, Xose S Puente, Stephan Stilgenbauer, Catherine J Wu, Elias Campo, Gad Getz

Faculty, Staff and Student Publications

Recent advances in cancer characterization have consistently revealed marked heterogeneity, impeding the completion of integrated molecular and clinical maps for each malignancy. Here, we focus on chronic lymphocytic leukemia (CLL), a B cell neoplasm with variable natural history that is conventionally categorized into two subtypes distinguished by extent of somatic mutations in the heavy-chain variable region of immunoglobulin genes (IGHV). To build the 'CLL map,' we integrated genomic, transcriptomic and epigenomic data from 1,148 patients. We identified 202 candidate genetic drivers of CLL (109 new) and refined the characterization of IGHV subtypes, which revealed distinct genomic landscapes and leukemogenic trajectories. …

T Cells Specific For Α-Myosin Drive Immunotherapy-Related Myocarditis, Margaret L Axelrod, Wouter C Meijers, Elles M Screever, Juan Qin, Mary Grace Carroll, Xiaopeng Sun, Elie Tannous, Yueli Zhang, Ayaka Sugiura, Brandie C Taylor, Ann Hanna, Shaoyi Zhang, Kaushik Amancherla, Warren Tai, Jordan J Wright, Spencer C Wei, Susan R Opalenik, Abigail L Toren, Jeffrey C Rathmell, P Brent Ferrell, Elizabeth J Phillips, Simon Mallal, Douglas B Johnson, James P Allison, Javid J Moslehi, Justin M Balko

Faculty, Staff and Student Publications

Immune-related adverse events, particularly severe toxicities such as myocarditis, are major challenges to the utility of immune checkpoint inhibitors (ICIs) in anticancer therapy1. The pathogenesis of ICI-associated myocarditis (ICI-MC) is poorly understood. Pdcd1-/-Ctla4+/- mice recapitulate clinicopathological features of ICI-MC, including myocardial T cell infiltration2. Here, using single-cell RNA and T cell receptor (TCR) sequencing of cardiac immune infiltrates from Pdcd1-/-Ctla4+/- mice, we identify clonal effector CD8+ T cells as the dominant cell population. Treatment with anti-CD8-depleting, but not anti-CD4-depleting, antibodies improved the survival of Pdcd1-/-Ctla4+/- mice. Adoptive transfer of immune cells from mice with myocarditis induced fatal myocarditis in recipients, …

Real-World Utilization And Outcomes Of Systemic Therapy Among Patients With Advanced Or Recurrent Endometrial Cancer In The United States, Jinan Liu, Bruno Emond, Eric M Maiese, Marie-Hélène Lafeuille, Patrick Lefebvre, Isabelle Ghelerter, Caterina Wu, Jean A Hurteau, Premal H Thaker

2020-Current year OA Pubs

OBJECTIVE: Evaluate systemic therapy utilization patterns and outcomes by line of therapy among patients with advanced/recurrent endometrial cancer (EC) treated in the United States.

METHODS: This retrospective observational study used the Optum Clinformatics Extended Data Mart Date of Death database (1 January 2004-31 December 2019) and included de-identified data from adult patients with advanced/recurrent EC who were treated with first-line (1L) platinum-based chemotherapy and initiated second-line (2L) anti-neoplastic therapy. The index date was the date of 1L therapy initiation. The number and sequence of treatments received and the proportion of patients who received each type of treatment for each line …

Hydrologic And Environmental Thresholds In Stream Fish Assemblage Structure Across Flow Regimes, J. Tyler Fox, Daniel D. Magoulick

Biological Sciences Faculty Publications and Presentations

The characteristic pattern of variation in flow magnitude, frequency, duration, timing, and rate of change defines the flow regime of rivers and streams and is a key driver of ecosystem processes in fluvial ecosystems. Under-standing how freshwater biotic assemblages change across gradients of hydrology and anthropogenic-source disturbance in different streamflow regimes is crucial to managing for sustainable environmental flows and watershed conservation. We compiled long-term (1916-2016) occurrence records for fishes collected in the Ouachita-Ozark Interior Highlands and West Gulf Coastal Plain streams, together with hydrologic metrics calculated from daily streamflow data measured at USGS stream gauging stations (n = 111), …

A Randomized Phase Ii Study Of Sm-88 Plus Methoxsalen, Phenytoin, And Sirolimus In Patients With Metastatic Pancreatic Cancer Treated In The Second Line And Beyond, Marcus S Noel, Semmie Kim, Marion L Hartley, Steve Wong, Vincent J Picozzi, Harry Staszewski, Dae Won Kim, Jan M Van Tornout, Philip Agop Philip, Vincent Chung, Allyson J Ocean, Andrea Wang-Gillam

2020-Current year OA Pubs

BACKGROUND: This trial explores SM-88 used with methoxsalen, phenytoin, and sirolimus (MPS) in pretreated metastatic pancreatic ductal adenocarcinoma (mPDAC) METHODS: Forty-nine patients were randomized to daily 460 or 920 mg oral SM-88 with MPS (SM-88 Regimen). The primary endpoint was objective response rate (RECIST 1.1).

RESULTS: Thirty-seven patients completed ≥ one cycle of SM-88 Regimen (response evaluable population). Disease control rate (DCR), overall survival (OS), and progression-free survival (PFS) did not differ significantly between dose levels. Stable disease was achieved in 9/37 patients (DCR, 24.3%); there were no complete or partial responses. Quality-of-life (QOL) was maintained and trended in favor …

The Skin Through Reflectance Confocal Microscopy - Historical Background, Technical Principles, And Its Correlation With Histopathology, Naiara Braghiroli

All Publications

Since its first introduction into medical practice, reflectance confocal microscopy (RCM) has been a valuable non-invasive diagnostic tool for the assessment of benign and malignant neoplasms of the skin. It has also been used as an adjunct for diagnosing equivocal cutaneous neoplasms that lack characteristic clinical or dermoscopic features. The use of RCM has led to a decreased number of biopsies of benign lesions. Multiple published studies show a strong correlation between RCM and histopathology thereby creating a bridge between clinical aspects, dermoscopy, and histopathology. Dermatopathologists may potentially play an important role in the interpretation of confocal images, by their …

The Use Of Iv Vasoactive Intestinal Peptide (Aviptadil) In Patients With Critical Covid-19 Respiratory Failure: Results Of A 60-Day Randomized Controlled Trial, Javier Perez-Fernandez

All Publications

Objectives: Respiratory failure is a lethal complication of COVID-19 that has remained resistant to drug therapy. Vasoactive intestinal peptide (VIP) is shown in nonclinical studies to upregulate surfactant production, inhibit cytokine synthesis, prevent cytopathy, and block replication of the severe acute respiratory syndrome coronavirus 2 virus in pulmonary cells. The study aims to determine whether Aviptadil (synthetic VIP) can improve survival and recovery in patients with COVID-19 respiratory failure compared with placebo and demonstrate biological effects in such patients.

Design: A multicenter, placebo-controlled trial.

Setting: Ten U.S. hospitals: six tertiary-care hospitals and four community hospitals.

Patients: A total of 196 …

“Everything…Fell Apart Once Covid-19 Hit”—Leveraging The Covid-19 Response To Strengthen Public Health Activities Toward Ending The Hiv Epidemic: A Qualitative Study, Samantha A. Devlin, Moctezuma Garcia, Kayo Fujimoto, Camden Hallmark, Marlene Mcneese, John Schneider, Moira C. Mcnulty

Faculty Research, Scholarly, and Creative Activity

COVID-19 caused widespread disruption of activities for Ending the HIV Epidemic (EHE). In this study we assessed public health perspectives on leveraging the COVID-19 response to advance the goals of EHE. We conducted a qualitative study with 33 public health partners in the Midwestern and Southern United States from October 2020 to February 2022. Participants were asked how the strategies developed for COVID-19 could be applied to the HIV epidemic. Interviews were recorded, transcribed, and examined using rapid qualitative analysis. Four themes emerged: (1) Rebuilding teams and adapting culture for success in EHE activities; (2) Recognizing and modernizing the role …

Ecological Chemistry Of Pest Control In Push- Pull Intercropping Systems: What We Know, And Where To Go?, Jakob Lang, Frank Chidawanyika, Zeyaur R. Khan, Meredith C. Schuman

All Peer-Reviewed Publications

Push-pull technology (PPT) employs mixed cropping for sustainable intensification: an intercrop repels or suppresses pests of the focal crop (push), while a trap crop attracts pests out of the field (pull), where they may be targeted for control. Underlying chemical-ecological mechanisms have been demonstrated in controlled settings, primarily for some of the best-established cereal PPT systems developed in east Africa. Yet, many questions remain regarding mechanisms, and strategies to adapt PPT for different crops and locations. We conducted a systematic review of scientific literature on PPT and related practices for biological control of pests of food and fodder. Of 3335 …

Tephritid Fruit Fly Species Composition, Seasonality, And Fruit Infestations In Two Central African Agro-Ecological Zones, Samuel Nanga Nanga, Rachid Hanna, Apollin Fotso Kuate, Komi K.M. Fiaboe, Ibrahim Nchoutnji, Michel Ndjab, Désiré Gnanvossou, Samira A. Mohamed, Sunday Ekesi, Champlain Djieto-Lordon

All Peer-Reviewed Publications

Bactrocera dorsalis and several Africa-native Ceratitis species are serious constraints to fruit production in sub-Saharan Africa. A long-term trapping and fruit collection study was conducted (2011–2016) in two contrasting agro-ecological zones (AEZs) of Cameroon to determine fruit fly species composition, seasonality, attraction to various lures and baits, and fruit infestation levels. Ten tephritid species from genera Bactrocera, Ceratitis, Dacus, and Perilampsis were captured in traps. Bactrocera dorsalis was the most dominant of the trapped species and persisted throughout the year, with peak populations in May–June. Ceratitis spp. were less abundant than B. dorsalis, with Ceratitis anonae dominating in the western …

The Role Of Nitrogen Fixation And Crop N Dynamics On Performance And Legacy Effects Of Maize-Grain Legumes Intercrops On Smallholder Farms In Tanzania, E. Mugi-Ngenga, L. Bastiaans, S. Zingore, N. P.R. Anten, K. E. Giller

All Peer-Reviewed Publications

Maize-grain legume intercrops form an important component of the cropping systems of smallholder farmers in many parts of sub-Saharan Africa. However, the effects of cropping system and fertilizer use on nitrogen fixation and nitrogen uptake of component crops in maize-legume intercrops are not well understood. Our study addressed the questions: (i) What is the capacity of pigeonpea and lablab to fix atmospheric nitrogen (N2) in sole crop and when intercropped with maize on smallholder farms across different agro-ecological conditions?; (ii) How does productivity and N-uptake by sole and intercropped maize and legumes respond to N and P fertilizer?; and (iii) …

The Influence Of Social Capital On First-Generation African American Gradaute Students: A Grounded Theory, Janeisha Anderson

Dissertations

First-generation African American/Black graduate students face challenges that must be overcome if they are to persist to degree completion. However, literature on factors contributing to their success and circumstances that hinder their academic outcomes is sparse. This qualitative grounded theory study investigated social capital and its influence on first-generation African American/Black graduate students' success. Participants (n = 17) were purposefully selected and included students who were enrolled or had already graduated, and others who had withdrawn from their graduate program. Thematic analysis of 17 interviews identified three primary themes: support within an academic setting, external support outside of an educational …

Evidence For The Effects Of Decommissioning Man-Made Structures On Marine Ecosystems Globally: A Systematic Map, Anaëlle J. Lemasson, Paul J. Somerfield, Michaela Schratzberger, Caroline Louise Mcneill, Joana Nunes, Christine Pascoe, Stephen C.L. Watson, Murray S.A. Thompson, Elena Couce, Antony M. Knights

School of Biological and Marine Sciences

Background: Many marine man-made structures (MMS), such as oil and gas platforms or offshore wind turbines, are nearing their ‘end-of-life’ and require decommissioning. Limited understanding of MMS decommissioning effects currently restricts the consideration of alternative management possibilities, often leaving complete removal as the only option in certain parts of the world. This evidence-base describes the ecosystem effects of marine MMS whilst in place and following cessation of operations, with a view to informing decision-making related to their potential decommissioning. Method: The protocol used to create this map was published a priori. Systematic searches of published, literature in English were conducted …

The Role Of Mindfulness Training In Sustaining Weight Reduction: Retrospective Cohort Analysis, P Hanson, M Lange, D Oduro-Donkor, E Shuttlewood, Et Al

Peninsula Medical School

Background Psychological stress has an established bi-directional relationship with obesity. Mindfulness techniques reduce stress and improve eating behaviours, but their long-term impact remains untested. CALMPOD (Compassionate Approach to Living Mindfully for Prevention of Disease) is a psychoeducational mindfulness-based course evidenced to improve eating patterns across a 6-month period, possibly by reducing stress. However, no long-term evaluation of impact exists. Aims This study retrospectively evaluates 2-year outcomes of CALMPOD on patient engagement, weight and metabolic markers. Method All adults with a body mass index >35 kg/m2 attending an UK obesity service during 2016–2020 were offered CALMPOD. Those who refused CALMPOD were …

Metabolic Syndrome In Fasting And Non-Fasting Participants: The Uae Healthy Future Study, Fatima Mezhal, Amar Ahmad, Abdishakur Abdulle, Andrea Leinberger-Jabari, Abderrahim Oulhaj, Abdulla Aljunaibi, Abdulla Alnaeemi, Ayesha S. Al Dhaheri, Eiman Alzaabi, Fatma Al-Maskari, Fatme Alanouti, Habiba Alsafar, Juma Alkaabi, Laila Abdel Wareth, Mai Aljaber, Marina Kazim, Manal Alblooshi, Mohammad Al-Houqani, Mohammad Hag Ali, Naima Oumeziane, Omar El-Shahawy, Rami H. Al-Rifai, Scott Sherman, Syed M. Shah, Tom Loney, Wael Almahmeed, Youssef Idaghdour, Luai A. Ahmed

All Works

Introduction: Metabolic syndrome (MetS) is a multiplex of risk factors that predispose people to the development of diabetes and cardiovascular disease (CVD), two of the major non-communicable diseases that contribute to mortality in the United Arab Emirates (UAE). MetS guidelines require the testing of fasting samples, but there are evidence-based suggestions that non-fasting samples are also reliable for CVD-related screening measures. In this study, we aimed to estimate MetS and its components in a sample of young Emiratis using HbA1c as another glycemic marker. We also aimed to estimate the associations of some known CVD risk factors with MetS in …

Catalytic Reduction Of Dyes And Antibacterial Activity Of Agnps@Zn@Alginate Composite Aerogel Beads, Fadila Benali, Bouhadjar Boukoussa, Nour El Houda Benkhedouda, Amina Cheddad, Ismail Issam, Jibran Iqbal, Mohammed Hachemaoui, Mohamed Abboud, Adel Mokhtar

All Works

This work focuses on the preparation of aerogel composite beads based on Zn(II)-crosslinked alginate and loaded with different percentages of AgNPs using a simple approach. The obtained samples were evaluated in two different applications: the first application consists in their use as catalysts for the reduction of MB, MO, OG and CR dyes in a simple and binary system under the presence of NaBH4. For this, several parameters affecting the catalytic behavior of these catalysts have been investigated and discussed such as the catalyst mass, AgNPs content, dye nature, and the selectivity of the catalyst in a binary system. The …

Does Trait Self-Esteem Serve As A Resilience Factor In Maintaining Affective Well-Being? Findings From Daily Diary Studies In Singapore And The United States, Matthew H. S. Ng, Verity Yu Qing Lua, Nadyanna M. Majeed, Andree Hartanto

Research Collection School of Social Sciences

Research suggests that self-esteem could be a protective factor in stressful or unfavorable situations. However, little research has been done on the buffering role of self-esteem in the context of daily stressors on affective reactivity. Three daily diary studies (of which two were conducted in Singapore and one in the United States) were carried out to examine this relationship. In all three studies, trait self-esteem was measured at baseline. Subsequently, daily assessment was conducted on exposure to daily stressors, and positive and negative affect for seven to eight days. Multilevel modeling showed that trait self-esteem did not moderate the relationship …

Individual Costs And Community Benefits: Collectivism And Individuals’ Compliance With Public Health Interventions, Suyi Leong, Kimin Eom, Keiko Ishii, Marion C. Aichberger, Karolina Fetz, Tim S. Müller, Heejung S. Kim, David K. Sherman

Research Collection School of Social Sciences

Differences in national responses to COVID-19 have been associated with the cultural value of collectivism. The present research builds on these findings by examining the relationship between collectivism at the individual level and adherence to public health recommendations to combat COVID-19 during the pre-vaccination stage of the pandemic, and examines different characteristics of collectivism (i.e., concern for community, trust in institutions, perceived social norms) as potential psychological mechanisms that could explain greater compliance. A study with a cross-section of American participants (N = 530) examined the relationship between collectivism and opting-in to digital contact tracing (DCT) and wearing face coverings …

Tracking The Associative Boost In Infancy, Kim Plunkett, Luche C Delle, Thomas Hills, Caroline Floccia

School of Psychology

Do words that are both associatively and taxonomically related prime each other in the infant mental lexicon? We explore the impact of these semantic relations in the emerging lexicon. Using the head-turn preference procedure, we show that 18-month-old infants have begun to construct a semantic network of associatively and taxonomically related words, such as dog-cat or apple-cheese. We demonstrate that priming between words is longer-lasting when the relationship is both taxonomic and associative, as opposed to purely taxonomic, reflecting the associative boost reported in the adult priming literature. Our results demonstrate that 18-month-old infants are able to construct a lexical-semantic …

Acute Pulmonary Exacerbation Phenotypes In Patients With Cystic Fibrosis, Suzanne C. Carter, Alessandro N. Franciosi, Kate M. O'Shea, Orla M. O'Carroll, Ashutosh Sharma, Aoife Bell, Brian Keogan, Paul O'Reilly, Suzie Coughlan, Sheonagh M. Law, Robert D. Gray, Katherine B. Hisert, Pradeep K. Singh, Gordon Cooke, Brenda Grogan, Cillian F. De Gascun, Charles G. Gallagher, Trevor T. Nicholson, Bradley S. Quon, Edward F. Mckone

Research Outputs: 2025-Present

Rationale: The etiology of cystic fibrosis (CF) pulmonary exacerbations (PEx) is likely multifactorial with viral, bacterial, and non-infectious pathways contributing. Objectives: To determine whether viral infection status and CRP (C-reactive protein) can classify subphenotypes of PEx that differ in outcomes and biomarker profiles. Methods: Patients were recruited at time of admission for a PEx. Nasal swabs and sputum samples were collected and processed using the respiratory panel of the FilmArray multiplex polymerase chain reaction (PCR). Serum and plasma biomarkers were measured. PEx were classified using serum CRP and viral PCR: "pauci-inflammatory" if CRP < 5 mg/L, "non-viral with systemic inflammation" if CRP ⩾ 5 mg/L and no viral infection detected by PCR and "viral with systemic inflammation" if CRP ⩾ 5 mg/L and viral infection detected by PCR. Results: Discovery cohort (n = 59) subphenotype frequencies were 1) pauci-inflammatory (37%); 2) non-viral with systemic inflammation (41%); and 3) viral with systemic inflammation (22%). Immunoglobulin G, immunoglobulin M, interleukin-10, interleukin-13, serum calprotectin, and CRP levels differed across phenotypes. Reduction from baseline in forced expiratory volume in 1 second as percent predicted (FEV1pp) at onset of exacerbation differed between non-viral with systemic inflammation and viral with systemic inflammation (-6.73 ± 1.78 vs. -13.5 ± 2.32%; P = 0.025). Non-viral with systemic inflammation PEx had a trend toward longer duration of intravenous antibiotics versus pauci-inflammation (18.1 ± 1.17 vs. 14.8 ± 1.19 days, P = 0.057). There were no differences in percent with lung function recovery to <10% of baseline FEV1pp. Similar results were seen in local and external validation cohorts comparing a pauci-inflammatory to viral/non-viral inflammatory exacerbation phenotypes. Conclusions: Subphenotypes of CF PEx exist with differences in biomarker profile, clinical presentation, and outcomes.

The Influence Of Language On Thematic Apperception Test Assessment Of Defenses In International Spanish-Speaking College Students, Ilenia Perez-Palen

Theses and Dissertations

Cultural influences, including the use of language, have been shown to affect personality development and are also likely to impact personality assessment results. The influence of language is particularly relevant in story-telling measures such as the Thematic Apperception Test (TAT; Morgan & Murray, 1935). The purpose of this study was to analyze TAT narratives delivered in English and Spanish to assess the application of defense mechanisms based on the Defense Mechanism Manual (DMM; Cramer, 1991) among Hispanic international students. No study to date has provided insight into Hispanic individuals’ use of language with the TAT, specifically on scores for the …

Dll3 As An Emerging Target For The Treatment Of Neuroendocrine Neoplasms, James Yao, Emily Bergsland, Rahul Aggarwal, Ana Aparicio, Himisha Beltran, Judy S. Crabtree, Christine L. Hann, Toni Ibrahim, Lauren A. Byers, Hironobu Sasano, John Umejiego, Marianne Pavel

School of Medicine Faculty Publications

Introduction: Neuroendocrine neoplasms (NEN) are heterogeneous malignancies that can arise at almost any anatomical site and are classified as biologically distinct well-differentiated neuroendocrine tumors (NET) and poorly differentiated neuroendocrine carcinomas (NEC). Current systemic therapies for advanced disease, including targeted therapies, chemotherapy, and immunotherapy, are associated with limited duration of response. New therapeutic targets are needed. One promising target is delta-like ligand 3 (DLL3), an inhibitory ligand of the Notch receptor whose overexpression on the surface of NEN is associated with tumorigenesis. Methods: This article is a narrative review that highlights the role of DLL3 in NEN progression and prognosis, the …

Cerebellar Coordination Of Neuronal And Behavioral Rhythms, Brittany Correia Chapman

Theses and Dissertations (ETD)

Long known for its role in motor control, it is increasingly clear that the cerebellum is also involved in numerous cognitive and affective behaviors. Though the neuronal mechanism for the role of the cerebellum in cognition is still unclear, there is a consensus that it involves cerebellar interactions with the cerebral cortex. Recent studies suggest that the cerebellum monitors, and possibly coordinates, the precise phase alignment or coherence of neuronal oscillations in cerebral cortical areas. Here, we asked how loss of cerebellar function affects respiratory rhythms and the interactions of local field potential (LFP) oscillations between the lobulus simplex (LS) …

Risk For Preeclampsia Associated With Nutritional Deficiencies And Modified By Apol1 Genotype, Winter S. Bruner

Theses and Dissertations (ETD)

Preeclampsia (PE) is a hypertensive disorder of pregnancy that is associated with micronutrient deficiencies. Nutrients involved in placental health and maintenance, such as vitamin D and folate, are important nutrients to assess in the risk of PE. As gestational age increases, the levels of vitamin D and folate potentially have incrementally increasing concentrations associated with PE. In addition to micronutrient deficiencies, PE is also associated with the presence of APOL1 high-risk (HR) variants. It was also hypothesized that a potential additive effect exists between HR APOL1 genotype status and nutritional deficiencies that would place individuals at a higher risk of …

Removal Of Heavy Metals From Stormwater Runoff Using Granulated Drinking Water Treatment Residuals, Viravid Na Nagara, Dibyendu Sarkar, Evert J. Elzinga, Rupali Datta

Michigan Tech Publications, Part 1

Stormwater runoff is a significant source of heavy metals, including cadmium (Cd), chromium (Cr), and nickel (Ni), which pose ecological and human health problems. Various filter media have been evaluated for heavy metal removal from stormwater via adsorption, most involving chemical- or energy-intensive processes. Aluminum-based drinking water treatment residuals (WTR), a non-hazardous byproduct of drinking water treatment, are an inexpensive sorbent for heavy metals. However, the low permeability of WTR is a problem and requires mixing with sand and carbon materials to improve flow; but such amendments also reduce its sorption capacity. To overcome this problem, a granulated WTR sorbent …

Artificial Reefs In The Arabian Gulf: Benefits, Challenges And Recommendations For Policy-Makers, A Bartholomew, Ja Burt, Lb Firth

School of Biological and Marine Sciences

Artificial reef (AR) deployment has increased dramatically in the Arabian / Persian Gulf in recent years, and will likely continue as Gulf nations continue to develop their coastlines and expand fisheries. Unfortunately, there is little publicly-available information about AR programs in the Gulf, including information about management goals and program success. ARs can provide economic, social and ecological benefits, but they also have underappreciated risks associated with them. Benefits include increasing short-term catch rates for fisheries, increasing tourism, enhancing and protecting biodiversity and providing ecological services. Risks include exacerbating regional overfishing in the long-term, facilitating the spread of invasive species, …

Microfibers: Environmental Problems And Textile Solutions, Js Weis, Francesca De Falco

School of Geography, Earth and Environmental Sciences

Microplastics have become a topic of considerable concern and intensive study over the past decade. They have been found everywhere in the oceans, including the deepest trenches and remotest parts of the Arctic. They are ingested by many animals and some are incorporated into tissues. There is considerable effort in studying what effects they have on marine life. It has become clear that when water samples are collected in ways that prevent most long thin particles from escaping through pores of a net, the most abundant type of microplastics found in water and sediments are microfibers (fibers with dimensions less …