Digital Commons Network^™

Editorial: Epigenetics And Molecular Genetics Of Rare Tumors, Mauro Tognon, George A. Calin, Luis Del Valle

School of Medicine Faculty Publications

No abstract provided.

Non-Covid-19 Hospitalizations: Patients’ Experiences During The Covid-19 Pandemic, Julia Patrick

Patient Experience Journal

The purpose of this Qualitative Descriptive study was to describe the experience of hospitalized adults during the pandemic who did not have COVID-19. Semi-structured interviews were conducted with 20 English-speaking adults who were hospitalized on a medical or surgical floor after April 1, 2020 and were negative for COVID-19 throughout their entire hospital stay. The interview questions focused on the overall hospital experience, the nurse’s role in their experience, comfort needs, and the experience of having comfort needs met during the hospitalization. Conventional content analysis of the transcribed transcripts revealed five main themes related to the hospital experience: I don’t …

The Importance Of Patient Engagement In The Management Of Giant Cell Arteritis, Nikhil S. Patil, Maxwell J. Gelkopf, Santano L. Rodrigues, Arun Ne. Sundaram

Patient Experience Journal

Giant cell arteritis (GCA) is a vascular condition characterized by ocular, systemic and neurological symptoms. Visual loss is the dreaded complication of this condition, prompting expedient diagnosis and treatment. Treatment typically involves prolonged glucocorticoid therapy which is often accompanied by several undesired side effects. In this report, we document one patient’s experience with GCA, its treatment, and relapse. Particularly, the patient highlights the difficulties and successes he had with the disease and its treatment. We also document the physician perspective on this disease and its treatment, specifically discussing the significance of prolonged treatment with glucocorticoids. We comment on the importance …

Living With Brain Cancer: From Researcher To Patient, Stephen P. Chelko, Daniel L. Fay Ph.D.

Patient Experience Journal

As an academic researcher, my work-life revolves around testing the efficaciousness of pharmaceutical drugs on the prevention of cardiac dysfunction, arrhythmias, and sudden cardiac death in animal models of heart disease. I never thought I would go from someone studying a life-threatening disease to a patient living with one in twenty-four hours. Yet, that transformation occurred October 8, 2019. I was just appointed to Assistant Professor at Johns Hopkins University School of Medicine (JHUSOM), yet after sitting for my professional headshot I had a grand mal seizure. I cannot recall this event, but I bit the tip of my tongue …

Decision Support For Grassland Systems In Developing Countries, P. K. Thornton

IGC Proceedings (1977-2023)

Key points

1. Information flows in complex systems are often themselves highly complex, and decision support approaches based on linear input-output processes may have only limited impact.

2. How decisions are made, and how they can be appropriately supported, is often incompletely understood, in part because of inadequate understanding of the objectives and attitudes of all the decision makers involved.

3. Much of the developing world faces daunting problems in the coming 30 years, and appropriate information could play a critical role in dealing with these.

4. System complexity, household variability, and institutional intricacies have to be embraced rather than …

Contributor's Biographies

The John Carroll Review

No abstract provided.

Cover Image Research Summary

The Journal of Purdue Undergraduate Research

Undergraduate students from a range of majors take part in a biotechnology course to isolate and study bacteriophages, viruses that destroy bacteria cells by infecting them and reproducing inside them. Some bacteriophages may be able to help treat antibiotic-resistant bacteria. Students in the class recently named one of their bacteriophages for President Mitch Daniels.

Covid-19 And Its Economic Implications For Turkish Tour Guides, Mehmet Yavuz Çetinkaya, Zafer Öter

International Journal of Tour Guiding and Visitor Attraction Research

The COVID-19 outbreak, which became one of the most stunning pandemics of the modern era, had a truly global effect on the world economy in a short period of time. Almost all countries were negatively impacted by the outbreak, which practically paralysed global life and resulted in negative dynamics, unprecedented conditions, and obstacles. Türkiye was not immune to this, having felt seriously negative consequences during this period. Tourism, nearly coming to a complete interruption for the first time since World War II in the 21st century, happened to be one of the hardest hit industries. The industry of tourism in …

Tour Guides And Access To Trails: Problems In The Baħrija Area Of Malta, David Pace

International Journal of Tour Guiding and Visitor Attraction Research

The Maltese islands barely cover an area of 300 square kilometres and yet, they enjoy a varied landscape characterised by cliffs, ridges, hills and valleys. There are over a hundred valleys on the main island of Malta and many provide important waterways during the rainy season and present some of the most beautiful and varied scenery. The most accessible include the Qlejgħa valley and White Poplar Valley (Wied il-Luq). Both are frequented by thousands of visitors, particularly during the weekends and are also quite popular with tourists during the winter months. Malta’s high population density, the influx of millions of …

Pseudonymous Was A Woman Pen Names, Louisa May Alcott, And Feme Covert, Claudia Stokes

English Faculty Research

No abstract provided.

Suffolk Journal, Vol.86, No. 6, 11/02/2022, Suffolk Journal

Suffolk Journal

No abstract provided.

Open With Intention: Situating Equity Pedagogy Within Open Education To Advance Social Justice, Stacy Katz, Jennifer Van Allen

Publications and Research

Purpose — This paper is intended to contextualize the major themes of the special issue, “The Intersections of Open Education and Equity Pedagogy” in the Journal for Multicultural Education, by providing a brief history of open educational resources (OER) and open educational practices (OEP) and highlighting the growing focus on social justice within the field. The purpose of this paper is to generate discussions around the potential of OER and OEP to increase equity within education.

Design/methodology/approach — This featured paper summarizes and reviews a brief history of OER and OEP, discusses the integration of equity pedagogy within open education, …

Strategies Of Protected Area Use By Asian Elephants In Relation To Motivational State And Social Affiliations, Anastasia E. Madsen, Christin Minge, T.V. Pushpakumara, U. Sameera Weerathunga, U. K. Padmalal, Devaka K. Weerakoon, Shermin De Silva

School of Biological Sciences: Faculty Publications

Animals’ space requirements may vary according to life-history and social considerations. We observed 516 wild adult Asian elephants from both sexes, over 9 years, to investigate how life-history traits and social behavior influence protected-area (PA) use at Udawalawe National Park, Sri Lanka. Male PA-use, quantified in terms of average between-sightings-interval (BSI), was significantly influenced by the interaction of age class and motivational state (i.e. reproduction vs. foraging). Musth lengthened with age, with a median of 24.5 days for ages 21–30, 32.5 days for ages 31–40, and 45 days for those > 40. A minority (11%) used it exclusively during musth, while …

The Bg News November 2, 2022, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. November 02, 2022. Volume 102-Issue 10.

The Lumberjack, November 02, 2022

Cal Poly Humboldt's Student Newspaper

The student newspaper of Humboldt State University.

Threonine Phosphorylation Of An Electrochemical Peptide-Based Sensor To Achieve Improved Uranyl Ion Binding Affinity, Channing C. Thompson, Rebecca Lai

Department of Chemistry: Faculty Publications

We have successfully designed a uranyl ion (U(VI)-specific peptide and used it in the fabrication of an electrochemical sensor. The 12-amino acid peptide sequence, (n) DKDGDGYIpTAAE (c), originates from calmodulin, a Ca(II)-binding protein, and contains a phosphothreonine that enhances the sequence’s affinity for U(VI) over Ca(II). The sensing mechanism of this U(VI) sensor is similar to other electrochemical peptide-based sensors, which relies on the change in the flexibility of the peptide probe upon interacting with the target. The sensor was systematically characterized using alternating current voltammetry (ACV) and cyclic voltammetry. Its limit of detection was 50 nM, which is lower …

Review Of Structural Color In The Genus Chrysochroa Dejean, 1833 (Coleoptera: Buprestidae), Able Chow

LSU Master's Theses

The jewel beetles, (Coleoptera: Buprestidae Leach, 1815), is the eighth most speciose coleopteran family, with the majority of its members possessing diverse bright, saturated structural coloration of multilayer origin. This study focuses on the genus Chrysochroa Dejean, 1833, which includes some of the most brilliantly and charismatically colored buprestid species. While members of Chrysochroa are prised by entomologists amateurs and professional and are well-represented in museum collections, the evolution and ecology of their structural color remain underexplored. Twenty-eight select taxa including exemplars from all 13 subgenera of Chrysochroa were investigated to provide an overview of the objective optical properties and …

Color, Culture, And The Implications For Emotional, Cognitive, And Behavioral Reactions, Renee Lucas

LSU Master's Theses

Color plays a significant role in life, influencing how we perceive things, how symbols change in meaning, how brands, logos, and pictograms are communicated, as well as how our emotions are perceived and how our moods are affected. For designers, advertisers, and visual communicators, color is crucial because it has a big impact on how people perceive, relate to, and value an image or advertisement. There are many factors that play a role when people develop their personal color interpretations – one being culture. The purpose of this study is to investigate the links between culture, color, and individuals’ cognitive, …

Largest-Ever Freshman Class Powers Overall Enrollment Growth, Erin Garrett

University of Mississippi News

Student retention rate climbs to a record high of 89%

November 2, 2022, The Dakota Student

The Dakota Student

No abstract provided.

Hormonal Therapies Up-Regulate Manf And Overcome Female Susceptibility To Immune Checkpoint Inhibitor Myocarditis, Yaohua Zhang, Chengcao Sun, Yajuan Li, Juan Qin, Kaushik Amancherla, Ying Jing, Qingsong Hu, Ke Liang, Zhao Zhang, Youqiong Ye, Lisa A Huang, Tina K Nguyen, Sergey D Egranov, Zilong Zhao, Andrew Wu, Yutao Xi, Jun Yao, Mien-Chie Hung, George A Calin, Jie Cheng, Bora Lim, Lorenz H Lehmann, Joe-Elie Salem, Douglas B Johnson, Michael A Curran, Dihua Yu, Leng Han, Radbod Darabi, Liuqing Yang, Javid J Moslehi, Chunru Lin

Faculty, Staff and Student Publications

Immune checkpoint inhibitors (ICIs) have been increasingly used in combination for cancer treatment but are associated with myocarditis. Here, we report that tumor-bearing mice exhibited response to treatment with combinatorial anti-programmed cell death 1 and anti-cytotoxic T lymphocyte antigen-4 antibodies but also presented with cardiovascular toxicities observed clinically with ICI therapy, including myocarditis and arrhythmia. Female mice were preferentially affected with myocarditis compared to male mice, consistent with a previously described genetic model of ICI myocarditis and emerging clinical data. Mechanistically, myocardial tissue from ICI-treated mice, the genetic mouse model, and human heart tissue from affected patients with ICI myocarditis …

The Single-Cell Immunogenomic Landscape Of B And Plasma Cells In Early-Stage Lung Adenocarcinoma, Dapeng Hao, Guangchun Han, Ansam Sinjab, Lorena Isabel Gomez-Bolanos, Rossana Lazcano, Alejandra Serrano, Sharia D Hernandez, Enyu Dai, Xuanye Cao, Jian Hu, Minghao Dang, Ruiping Wang, Yanshuo Chu, Xingzhi Song, Jianhua Zhang, Edwin R Parra, Jennifer A Wargo, Stephen G Swisher, Tina Cascone, Boris Sepesi, Andrew P Futreal, Mingyao Li, Steven M Dubinett, Junya Fujimoto, Luisa M Solis Soto, Ignacio I Wistuba, Christopher S Stevenson, Avrum Spira, Shabnam Shalapour, Humam Kadara, Linghua Wang

Faculty, Staff and Student Publications

Tumor-infiltrating B and plasma cells (TIB) are prevalent in lung adenocarcinoma (LUAD); however, they are poorly characterized. We performed paired single-cell RNA and B-cell receptor (BCR) sequencing of 16 early-stage LUADs and 47 matching multiregion normal tissues. By integrative analysis of ∼50,000 TIBs, we define 12 TIB subsets in the LUAD and adjacent normal ecosystems and demonstrate extensive remodeling of TIBs in LUADs. Memory B cells and plasma cells (PC) were highly enriched in tumor tissues with more differentiated states and increased frequencies of somatic hypermutation. Smokers exhibited markedly elevated PCs and PCs with distinct differentiation trajectories. BCR clonotype diversity …

The Benefits And Challenges Of Virtual Education For Interprofessional Teams In A Post-Covid Environment, Tiffany Champagne-Langabeer

Faculty, Staff and Student Publications

There have been a series of disruptions in the healthcare environment since 2019, starting with the global pandemic [...].

Targeting The Eif2ak1 Signaling Pathway Rescues Red Blood Cell Production In Sf3b1-Mutant Myelodysplastic Syndromes With Ringed Sideroblasts, Vera Adema, Feiyang Ma, Rashmi Kanagal-Shamanna, Natthakan Thongon, Guillermo Montalban-Bravo, Hui Yang, Scott A Peslak, Feng Wang, Pamela Acha, Francesc Sole, Pamela Lockyer, Margherita Cassari, Jaroslaw P Maciejewski, Valeria Visconte, Irene Gañán-Gómez, Yuanbin Song, Carlos Bueso-Ramos, Matteo Pellegrini, Tuyet M Tan, Rafael Bejar, Jennifer S Carew, Stephanie Halene, Valeria Santini, Gheath Al-Atrash, Karen Clise-Dwyer, Guillermo Garcia-Manero, Gerd A Blobel, Simona Colla

Faculty, Staff and Student Publications

SF3B1 mutations, which occur in 20% of patients with myelodysplastic syndromes (MDS), are the hallmarks of a specific MDS subtype, MDS with ringed sideroblasts (MDS-RS), which is characterized by the accumulation of erythroid precursors in the bone marrow and primarily affects the elderly population. Here, using single-cell technologies and functional validation studies of primary SF3B1-mutant MDS-RS samples, we show that SF3B1 mutations lead to the activation of the EIF2AK1 pathway in response to heme deficiency and that targeting this pathway rescues aberrant erythroid differentiation and enables the red blood cell maturation of MDS-RS erythroblasts. These data support the development of …

Strategies Of Protected Area Use By Asian Elephants In Relation To Motivational State And Social Affiliations, Anastasia E. Madsen, Christin Minge, T. V. Pushpakumara, U. Sameera Weerathunga, U. K. Padmalal, Devaka K. Weerakoon, Shermin De Silva

School of Biological Sciences: Faculty Publications

Animals’ space requirements may vary according to life-history and social considerations. We observed 516 wild adult Asian elephants from both sexes, over 9 years, to investigate how life-history traits and social behavior influence protected-area (PA) use at Udawalawe National Park, Sri Lanka. Male PA-use, quantified in terms of average between-sightings-interval (BSI), was significantly influenced by the interaction of age class and motivational state (i.e. reproduction vs. foraging). Musth lengthened with age, with a median of 24.5 days for ages 21–30, 32.5 days for ages 31–40, and 45 days for those > 40. A minority (11%) used it exclusively during musth, while …

The Global Jukebox: A Public Database Of Performing Arts And Culture, Anna L. C. Wood, Kathryn R. Kirby, Carol R. Ember, Stella Silbert, Sam Passmore, Hideo Daikoku, John Mcbride, Forrestine Paulay, Michael J. Flory, John Szinger, Gideon D'Arcangelo, Karen Kohn Bradley, Marco Guarino, Maisa Atayeva, Jesse Rifkin, Violet Baron, Miriam El Haljli, Martin Szinger, Patrick E. Savage

Publications and Research

Standardized cross-cultural databases of the arts are critical to a balanced scientific under- standing of the performing arts, and their role in other domains of human society. This paper introduces the Global Jukebox as a resource for comparative and cross-cultural study of the performing arts and culture. The Global Jukebox adds an extensive and detailed global database of the performing arts that enlarges our understanding of human cultural diversity. Initially prototyped by Alan Lomax in the 1980s, its core is the Cantometric s dataset, encompassing standardized codings on 37 aspects of musical style for 5,776 traditional songs from 1,026 societies. …

Investigating Students' Interpretations Of Ecological Food Webs, Christopher Neil Grissett

USF Tampa Graduate Theses and Dissertations

To better prepare undergraduate students for current and future biological challenges, scientists, educators and researchers in the Vision and Change report recommended five core conceptual areas essential for the improvement of biological literacy, one of which is biological systems. Systems are an identified core concept that may help promote biological literacy. One example of a system that students have difficulty understanding is an ecological food web, which consists of parts or components interacting with one another to perform a given phenomenon. The intricacies of this system tend to confuse students and can produce naïve conceptions that could hinder future learning …

Health Effects Of Oil Spills And Dispersal Of Oil Droplets And Zooplankton By Langmuir Cells, Sanjib Gurung

USF Tampa Graduate Theses and Dissertations

This Ph.D. dissertation deals with the study of the health effects of crude oil vapors from oil spills, the effect of Langmuir circulation on the dispersion of oil droplets during oil spill events, and the biological significance of Langmuir circulation. The introduction to areas of three major research projects undertaken during my Ph.D. is included in chapter 1 and the relevant literature review is included in chapter 2. The first research project described in chapter 3 involves the quantification of health effects on embryonic Gulf killifish due to exposure to crude oil vapors. The second research project described in chapter …

Community Scholars: A Diversity Pipeline Program To Promote Equity, Diversity, And Inclusion For People With Disabilities, Laura M. Rodríguez López

USF Tampa Graduate Theses and Dissertations

This dissertation in practice documents the program evaluation of the Community Scholars (CS) program at the Florida Center for Inclusive Communities (FCIC), a University Center for Excellence in Developmental Disabilities (UCEDD) at the University of South Florida (USF). CS is part of a diversity pipeline program that recruits youth with disabilities to engage in paid on-the-job training (OJT) with FCIC. Scholars are community members (youth with disabilities) that are enrolled as FCIC trainees and receive mentoring, development of basic administrative competencies, individualized career coaching, college counseling, and disability policy and self-advocacy training. Through the OJT experience, scholars gain skills that …

Ecology And Evolution Of Social Information Use, Clare T. M. Doherty

Dartmouth College Ph.D Dissertations

Sociality is a strategy many animals employ to cope with their environments, enabling them to survive and reproduce more successfully than would otherwise be possible. When navigating their environments and making decisions, social individuals often use information provided by conspecifics (in the form of social cues and signals), thereby increasing the scope and reliability of the information they can gather. However, social information use may be influenced by many factors, including key differences in context across the physical and social environment. My thesis asks and answers a series of questions regarding the trade-offs in social information use across different contexts, …