Digital Commons Network^™

Early-Childhood Temperament Moderates The Prospective Associations Of Coping With Adolescent Internalizing And Externalizing Symptoms, Michele R. Smith, Krystal H. Parrish, Lisa Shimomaeda, Maureen Zalewski, Maya L. Rosen, Alexandra Rodman, Steven Kasparek, Makeda Mayes, Andrew N. Meltzoff, Katie A. Mclaughlin, Liliana J. Lengua

Neuroscience: Faculty Publications

While appraisal and coping are known to impact adolescent psychopathology, more vulnerable or resilient responses to stress may depend on individual temperament. This study examined early life temperament as a moderator of the prospective relations of pre-adolescent appraisal and coping with adolescent psychopathology. The sample included 226 (62% female, 14–15 years) adolescents with assessments starting at 3 years of age. Adolescents were predominately White (12% Black 9% Asian, 11% Latinx, 4% Multiracial, and 65% White). Observed early-childhood temperament (fear, frustration, executive control, and delay ability) were tested as moderators of pre-adolescent coping (active and avoidant) and appraisal (threat, positive) on …

Salinity And Hydraulic Retention Time Induce Membrane Phospholipid Acyl Chain Remodeling In Halanaerobium Congolense Wg10 And Mixed Cultures From Hydraulically Fractured Shale Wells, Chika Jude Ugwuodo, Fabrizio Colosimo, Jishnu Adhikari, Yuxiang Shen, Appala Raju Badireddy, Paula J. Mouser

Faculty Publications

Bacteria remodel their plasma membrane lipidome to maintain key biophysical attributes in response to ecological disturbances. ForHalanaerobiumand other anaerobic halotolerant taxa that persist in hydraulically fractured deep subsurface shale reservoirs, salinity, and hydraulic retention time (HRT) are important perturbants of cell membrane structure, yet their effects remain poorly understood. Membrane-linked activities underliein situmicrobial growth kinetics and physiologies which drive biogeochemical reactions in engineered subsurface systems. Hence, we used gas chromatography–mass spectrometry (GC–MS) to investigate the effects of salinity and HRT on the phospholipid fatty acid composition ofH. congolenseWG10 and mixed enrichment cultures from hydraulically fractured shale wells. We also coupled …

Rickettsia Parkeri Infection Modulates The Sialome And Ovariome Of The Gulf Coast Tick, Amblyomma Maculatum, Melina Garcia Guizzo, Khemraj Budachetri, Abdulsalam Adegoke, Jose M.C. Ribeiro, Shahid Karim

Faculty Publications

The Gulf Coast tick, Amblyomma maculatum, is a vector of several tick-borne pathogens, including Rickettsia parkeri. The ability of R. parkeri to persist within the tick population through transovarial and transstadial transmission, without apparently harming the ticks, contributes to the pathogen’s perpetuation in the tick population. Previous studies have shown that the R. parkeri load in A. maculatum is regulated by the tick tissues’ oxidant/antioxidant balance and the non-pathogenic tick microbiome. To obtain further insights into the interaction between tick and pathogen, we performed a bulk RNA-Seq for differential transcriptomic analysis of ovaries and salivary …

Lifecourse Transitions: How Icts Support Older Migrants’ Adaptation To Transnational Lives, Hien Thi Nguyen, Loretta Baldassar, Raelene Wilding

Research outputs 2022 to 2026

Lifecourse transitions from adulthood into older age are particularly complex for transnational migrants, bringing additional challenges and opportunities. Adding to the growing literature on ageing and migration, this article illustrates the ways ICTs facilitate the transnational lifecourse transitions of Vietnamese migrant grandparents in Australia through lifecourse digital learning. Research findings highlight the crucial role that digital citizenship plays in supporting migrant grandparents’ adaptation to increasingly mobile lives through practices of digital kinning and digital homing. These practices include using technological tools to maintain social support networks, exchange transnational caregiving, tackle language, nav-igation, and social integration barriers, and consume culturally relevant …

The Montclarion, November 10, 2022, The Montclarion

The Montclarion

Student Newspaper of Montclair State University

Reproducibility Efforts As A Teaching Tool: A Pilot Study, Nestoras Karathanasis, Daniel Hwang, Vibol Heng, Rimal Abhimannyu, Phillip Slogoff-Sevilla, Gina Buchel, Victoria Frisbie, Peiyao Li, Dafni Kryoneriti, Isidore Rigoutsos

Computational Medicine Center Faculty Papers

The "replication crisis" is a methodological problem in which many scientific research findings have been difficult or impossible to replicate. Because the reproducibility of empirical results is an essential aspect of the scientific method, such failures endanger the credibility of theories based on them and possibly significant portions of scientific knowledge. An instance of the replication crisis, analytic replication, pertains to reproducing published results through computational reanalysis of the authors' original data. However, direct replications are costly, time-consuming, and unrewarded in today's publishing standards. We propose that bioinformatics and computational biology students replicate recent discoveries as part of their curriculum. …

Listening To The Outliers: Refining The Curriculum For Dissertation Camps, Bradley Hughes, Elisabeth L. Miller, Nancy Linh Karls

The Writing Center Journal

Seeking to support graduate student writers, writing centers at research universities have developed highly successful dissertation camps over the past 15 years. Previous research from North American dissertation camps has demonstrated significant benefits from these camps, as dissertation writers developed new writing habits and increased their productivity. In this study, however, a closer look at initial and follow-up survey responses provided by participants from dissertation camps at two institutions—an Upper Midwestern university in the United States that has held camps for 11 years and an Eastern European university that held an online camp during the 2020 pandemic—suggests that focusing on …

Effective Medical Waste Management For Sustainable Green Healthcare, Sang M. Lee, Donhee Lee

Department of Management: Faculty Publications

This study examines the importance of medical waste management activities for developing a sustainable green healthcare environment. This study applied a multiple methodological approach as follows. A thorough review of the literature was performed to delineate the factors that have been explored for reducing medical waste; hospital staff who handle medical waste were surveyed to obtain their opinions on these factors; the analytic hierarchy process (AHP) was applied to determine the priorities among the identified key factors; and experts’ opinions were consulted to assess the actual applicability of the results derived by the AHP. The study identified the following factors …

Microbiome Diversity And Metabolic Capacity Determines The Trophic Ecology Of The Holobiont In Caribbean Sponges, Michael P. Lesser, M. Sabrina Pankey, Marc Slattery, Keir J. Macartney, Deborah J. Gochfeld

School of Earth, Environmental, & Marine Sciences Faculty Publications

Sponges are increasingly recognized as an ecologically important taxon on coral reefs, representing significant biomass and biodiversity where sponges have replaced scleractinian corals. Most sponge species can be divided into two symbiotic states based on symbiont community structure and abundance (i.e., the microbiome), and are characterized as high microbial abundance (HMA) or low microbial abundance (LMA) sponges. Across the Caribbean, sponge species of the HMA or LMA symbiotic states differ in metabolic capacity, as well as their trophic ecology. A metagenetic analysis of symbiont 16 S rRNA and metagenomes showed that HMA sponge microbiomes are more functionally diverse than LMA …

Reducing Cost-Of-Care In Next-Generation Genetic Sequencing, Sarah Auletta

School of Business Student Scholarship

The cost of care in healthcare settings is rapidly rising, and it is increasingly difficult to decrease these costs without compromising quality and accessibility. This paper aims to investigate methods and potential opportunities for innovation of next-generation genetic sequencing in healthcare decisions and trajectories of care. Using various sources such as medical encyclopedias and peer-reviewed journal articles, this paper explores the ways in which genetic testing became popular in medicine and how genetic testing is currently being used. This knowledge is used to conclude the most likely trajectory of genetics within the field of medicine and its most cost-effective interventions. …

Fogelman, Charles, Sophia Maier Garcia

Bronx Jewish History Project

Charles Fogelman’s parents came to New York City as children in the beginning of the 20th century. They were married in 1932, and his father became a doctor, fighting antisemitic quotas to go to medical school, and completing his residency at Lincoln Hospital in the South Bronx. His father had a practice in the East Bronx, on Elder Avenue, when Fogelman was born in 1946 and he grew up in a semi-detached house nearby on Ward Avenue. He describes it as a lower-middle class, predominantly Jewish neighborhood, with Irish and Italian neighbors, and with many synagogues, so it felt very …

An Approach To The Gaussian Rbf Kernels Via Fock Spaces, Daniel Alpay, Fabrizio Colombo, Kamal Diki, Irene Sabadini

Mathematics, Physics, and Computer Science Faculty Articles and Research

We use methods from the Fock space and Segal–Bargmann theories to prove several results on the Gaussian RBF kernel in complex analysis. The latter is one of the most used kernels in modern machine learning kernel methods and in support vector machine classification algorithms. Complex analysis techniques allow us to consider several notions linked to the radial basis function (RBF) kernels, such as the feature space and the feature map, using the so-called Segal–Bargmann transform. We also show how the RBF kernels can be related to some of the most used operators in quantum mechanics and time frequency analysis; specifically, …

Sleep Disorders In Children With Prader Willi Syndrome: Current Perspectives., David G. Ingram Md, Jill M. Arganbright, Emily Paprocki, Kelsee Halpin

Manuscripts, Articles, Book Chapters and Other Papers

Children with Prader-Willi syndrome (PWS) face a multitude of potential health challenges including life-threatening obesity, endocrinopathies, behavioral and emotional dysregulation, developmental delays, and sleep disorders. In the current perspective piece, we provide a focused review of the condition's etiology and clinical findings, as well as a more in-depth discussion of sleep disorders frequently associated with PWS. In particular, we highlight and discuss difficult clinical scenarios frequently encountered by the pediatric sleep physician caring for this patient population, including diagnosis and treatment of complex sleep-related breathing disorders, considerations for sleep apnea surgery, the interplay between growth hormone and sleep apnea, diagnostic …

Structural And Biochemical Characterization Of Epigenetic And Fusion Tyrosine Kinase Cancer Targets For Drug Development, Melissa Bikowitz

USF Tampa Graduate Theses and Dissertations

Cancer is a significant global health burden, as ~40% of the human population is diagnosed with cancer over a lifetime, half of which succumb to the disease. To develop novel compounds as potential cancer therapeutics, an in-depth structural and biochemical understanding of proteins involved in oncogenesis is key. This dissertation centers around the comprehensive structural and biochemical characterization of two classes of proteins critical for cancer cell survival: bromodomain-containing proteins (BRDs) and fusion tyrosine kinases (FTKs).In 2010, small molecule inhibitors targeting bromodomains (epigenetic reader proteins) became heavily popularized due to the druggability and potent anticancer effects of BET inhibitors. …

The Smart Dementia Care Project, Dympna O'Sullivan, Jonathan Turner, Ciaran Nugent, Damon Berry, Michael Wilson, Julie Doyle

Articles

No abstract provided.

Targeting The Mdm2-P53 Pathway In Dedifferentiated Liposarcoma, Raymond S Traweek, Brandon M Cope, Christina L Roland, Emily Z Keung, Elise F Nassif, Derek J Erstad

Faculty, Staff and Student Publications

Dedifferentiated liposarcoma (DDLPS) is an aggressive adipogenic cancer with poor prognosis. DDLPS tumors are only modestly sensitive to chemotherapy and radiation, and there is a need for more effective therapies. Genetically, DDLPS is characterized by a low tumor mutational burden and frequent chromosomal structural abnormalities including amplification of the 12q13-15 chromosomal region and the MDM2 gene, which are defining features of DDLPS. The MDM2 protein is an E3 ubiquitin ligase that targets the tumor suppressor, p53, for proteasomal degradation. MDM2 amplification or overexpression in human malignancies is associated with cell-cycle progression and worse prognosis. The MDM2-p53 interaction has thus garnered …

Leadership Coaching: Are We Missing The Alchemy?, Raymond L. Forbes

All Faculty and Staff Scholarship

In an era characterized by fear, uncertainty and doubt Leadership Coaches now find themselves operating on more difficult and unfamiliar terrain. Enabling their clients to cope, survive and thrive in such tenuous conditions offers a significant professional challenge. This paper offers an unusual supplemental approach to more conventional and traditional coaching methods. Utilizing principles derived from the ancient field of alchemy, as well as from modern neuroscience, this article provides both new ideas and guidance to the practitioner of leadership coaching. Beginning with a guided imagery, this piece will then cover the connection between alchemy and leadership, followed by alchemy’s …

Trophic Model Closure Influences Ecosystem Response To Enrichment, Anne Willem Omta

Faculty Scholarship

There exists considerable uncertainty about the most appropriate functional form to describe mortality at the highest trophic level (the closure problem). Although linear and quadratic formulations predict strongly different dynamics, it is unclear which of these formulations is more realistic. We introduce an implicit predator population feeding on the highest trophic level, parameterized through a Holling Type II functional response and empirically observed predator–prey scaling relations. Thus, we arrive at a hyperbolic mortality formulation that is a hybrid between the linear and quadratic forms. Subsequently, we investigate the impact of this formulation on the modeled population dynamics. In particular, we …

The Student Movement Volume 107 Issue 8: Cuffing Season, Co-Curriculars, And Ctc Telehealth: The Student Movement Highlights Important Issues On Campus, Lauren Kim, Nora Martin, Caryn Cruz, Ceiry Flores, Solana Campbell, Skyler Campbell, Neesa Richards, Nicholas C. Gunn, Gloria Oh, Andrew Francis, T Bruggemann, Alexander Navarro, Jonathon Woolford-Hunt, Scott Moncrieff, Joseph Keough, Brendan Syto, Alannah Tjhatra

The Student Movement v. 107 (2022-2023)

HUMANS

CTC Prevention Coordinator/Staff Counselor Interview: Nycole Goldberg, Interviewed by: Lauren Kim

Meet Ellie Dovich: Cast/Cardinal Lead Editor, Interviewed by: Nora Martin

Women in Stem: A Peek into Physics, Interviewed by: Caryn Cruz

ARTS & ENTERTAINMENT

Creatives on Campus: Art via Insta, Ceiry Flores

Currently..., Solana Campbell

Spotlight: The Parent Trap, Skyler Campbell

NEWS

AUSA Senate News Update, November 2022, Neesa Richards, AUSA Senate Public Relations Officer

Governor Whitmer Takes A Stop In Benton Harbor, Nicholas C. Gunn

Home Season Opener, Solana Campbell

Hopes and Plans Behind the Seminary Center of Community Change, Interviewed by: Gloria Oh

The Days Speak …

Assessing The Contribution Of Rare Genetic Variants To Phenotypes Of Chronic Obstructive Pulmonary Disease Using Whole-Genome Sequence Data, Wonji Kim, Julian Hecker, R Graham Barr, Eric Boerwinkle, Brian Cade, Adolfo Correa, Josée Dupuis, Sina A Gharib, Leslie Lange, Stephanie J London, Alanna C Morrison, George T O'Connor, Elizabeth C Oelsner, Bruce M Psaty, Ramachandran S Vasan, Susan Redline, Stephen S Rich, Jerome I Rotter, Bing Yu, Christoph Lange, Ani Manichaikul, Jin J Zhou, Tamar Sofer, Edwin K Silverman, Dandi Qiao, Michael H Cho, Nhlbi Trans-Omics In Precision Medicine (Topmed) Consortium And Topmed Lung Working Group

Faculty, Staff and Students Publications

Rationale: Genetic variation has a substantial contribution to chronic obstructive pulmonary disease (COPD) and lung function measurements. Heritability estimates using genome-wide genotyping data can be biased if analyses do not appropriately account for the nonuniform distribution of genetic effects across the allele frequency and linkage disequilibrium (LD) spectrum. In addition, the contribution of rare variants has been unclear.

Objectives: We sought to assess the heritability of COPD and lung function using whole-genome sequence data from the Trans-Omics for Precision Medicine program.

Methods: Using the genome-based restricted maximum likelihood method, we partitioned the genome into bins based on minor allele frequency …

Erk Inhibitor Ulixertinib Inhibits High-Risk Neuroblastoma Growth In Vitro And In Vivo, Yang Yu, Yanling Zhao, Jongmin Choi, Zhongcheng Shi, Linjie Guo, John Elizarraras, Andy Gu, Feng Cheng, Yanxin Pei, Dai Lu, Muller Fabbri, Saurabh Agarwal, Chunchao Zhang, Sung Yun Jung, Jennifer H Foster, Jianhua Yang

Faculty, Staff and Students Publications

Neuroblastoma (NB) is a pediatric tumor of the peripheral nervous system. Approximately 80% of relapsed NB show RAS-MAPK pathway mutations that activate ERK, resulting in the promotion of cell proliferation and drug resistance. Ulixertinib, a first-in-class ERK-specific inhibitor, has shown promising antitumor activity in phase 1 clinical trials for advanced solid tumors. Here, we show that ulixertinib significantly and dose-dependently inhibits cell proliferation and colony formation in different NB cell lines, including PDX cells. Transcriptomic analysis revealed that ulixertinib extensively inhibits different oncogenic and neuronal developmental pathways, including EGFR, VEGF, WNT, MAPK, NGF, and NTRK1. The proteomic analysis further revealed …

Vista: November 10, 2022, University Of San Diego

USD Vista (1965-)

No abstract provided.

Acute And Postacute Sequelae Associated With Sars-Cov-2 Reinfection, Benjamin Bowe, Yan Xie, Ziyad Al-Aly

2020-Current year OA Pubs

First infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with increased risk of acute and postacute death and sequelae in various organ systems. Whether reinfection adds to risks incurred after first infection is unclear. Here we used the US Department of Veterans Affairs' national healthcare database to build a cohort of individuals with one SARS-CoV-2 infection (n = 443,588), reinfection (two or more infections, n = 40,947) and a noninfected control (n = 5,334,729). We used inverse probability-weighted survival models to estimate risks and 6-month burdens of death, hospitalization and incident sequelae. Compared to no reinfection, reinfection …

Spatiotemporal Metabolic Network Models Reveal Complex Autotroph-Heterotroph Biofilm Interactions Governed By Photon Incidences, Poonam Phalak, Hans C. Bernstein, Stephen R. Lindemann, Ryan S. Renslow, Dennis G. Thomas, Michael A. Henson, Hyun-Seob Song

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Autotroph-heterotroph interactions are ubiquitous in natural environment and play a key role in controlling various essential ecosystem functions, such as production and utilization of organic matter, cycling of nitrogen, sulfur, and other chemical elements. Understanding how these biofilm metabolic interactions are constrained in space and time remains challenging because fully predictive models designed for this purpose are currently limited. Toward filling this gap, here we developed community metabolic network models for two autotroph-heterotroph biofilm consortia (termed UCC-A and UCC-O), which share a suite of common heterotrophic members but have a single distinct photoautotrophic cyanobacterium (Phormidesmis priestleyi str. ANA and …

Key To The Species Of Tortanidae Tortanus Occurring In The China Seas, Chang-Tai Shih, Qing-Chao Chen, Yang-Chi Lan, Shih-Hui Hsiao, Chi-Yu Weng

Journal of Marine Science and Technology–Taiwan

No abstract provided.

Key To The Species Of Tharybidae Neoscolecithrix Occurring In The China Seas, Chang-Tai Shih, Qing-Chao Chen, Yang-Chi Lan, Shih-Hui Hsiao, Chi-Yu Weng

Journal of Marine Science and Technology–Taiwan

No abstract provided.

Key To The Species Of Temoridae Temora Occurring In The China Seas, Chang-Tai Shih, Qing-Chao Chen, Yang-Chi Lan, Shih-Hui Hsiao, Chi-Yu Weng

Journal of Marine Science and Technology–Taiwan

No abstract provided.

Key To The Species Of Subeucalanidae Subeucalanus Occurring In The China Seas, Chang-Tai Shih, Qing-Chao Chen, Yang-Chi Lan, Shih-Hui Hsiao, Chi-Yu Weng

Journal of Marine Science and Technology–Taiwan

No abstract provided.

Key To The Species Of Spinocalanidae Spinocalanus Occurring In The China Seas, Chang-Tai Shih, Qing-Chao Chen, Yang-Chi Lan, Shih-Hui Hsiao, Chi-Yu Weng

Journal of Marine Science and Technology–Taiwan

No abstract provided.

Key To The Species Of Spinocalanidae Monacilla Occurring In The China Seas, Chang-Tai Shih, Qing-Chao Chen, Yang-Chi Lan, Shih-Hui Hsiao, Chi-Yu Weng

Journal of Marine Science and Technology–Taiwan

No abstract provided.