Digital Commons Network^™

Preclinical Antibody-Pet Imaging Of Pd-L1, Emma L Brown, Rachel A Deweerd, Abbey Zidel, Patricia M R Pereira

2020-Current year OA Pubs

Programmed cell death protein-1/ligand-1 (PD-1/PD-L1) blockade, including antibody therapeutics, has transformed cancer treatment. However, a major challenge in the field relates to selecting patients who are likely to respond to immune checkpoint inhibitors. Indeed, biopsy-based diagnostic tests to determine immune checkpoint protein levels do not accurately capture the inherent spatial and temporal heterogeneity of PD-L1 tumor expression. As a result, not all PD-L1-positive tumors respond to immunotherapies, and some patients with PD-L1-negative tumors have shown clinical benefits. In 2018, a first-in-human study of the clinically-approved anti-PD-L1 antibody Atezolizumab labeled with the positron emitter zirconium-89 validated the ability of positron emission …

An Analysis Of Military Service Academies Sexual Harassment And Sexual Assault Through Reports, Research, And Media Coverage, Lisa “Tana” Youn Kyung Sharp

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

Military Sexual Trauma (MST) at the United States Military Services Academies (MSA) remains at a concerning rate despite the MSAs’ proactive educational steps towards addressing this issue. One of the most influential factors is the very culture of the MSAs. This paper analyzes publicly-accessible governmental research and reports, peer reviewed articles, a legal publication, and media coverage. The analysis shows that there remain significant barriers to change which continue to play a role in the high frequency of MST. These barriers are low rates of accountability, difficulty in access to cadets/midshipmen by outside researchers, and the overall MSA cultural trends …

The Devil’S Advocate: The Relational Therapist As Jung’S Fourth In The Treatment Of Queer Christian Clients, Whitney Wilson

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

This paper is an exploration of C.G. Jung’s essay, A Psychological Approach to the Dogma of the Trinity, and how he inadvertently provides a relational psychodynamic lens for working with queer Christian clients who are differentiating from their harmful, embedded theologies. Jung hypothesizes that the Christian Trinity archetype – the Father, Son, and Holy Ghost, cannot exist without a fourth member, the Devil, who holds an essential role in the successful differentiation of the Trinity. The relational therapist is called to act as the Devil when working with queer Christian clients - inviting in seemingly mischievous and dangerous thoughts that …

The Intersubjective Perspective: An Effective Treatment Model For Incarcerated Clients, Zachary Grant Weiss

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

Although there is already a large body of theoretical literature on the utility of Intersubjective Systems Theory in working with more challenging clinical presentations, little has been written about the use of this approach in working with incarcerated clients. In this paper, I will be making the case for the utility and need for the Intersubjective Perspective in working within the forensic system. This paper will first focus on building a general framework for Intersubjective Systems Theory, and its theoretical understanding of clients’ striving towards health, love and connection. Next, this paper will take time to focus on a brief …

Unreality And Loss Of Self: Dissociative Experiences In Buddhist Practitioners, Jill Loving

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

On the surface, the Buddhist idea of emptiness and experiences of depersonalization and derealization seem to have significant overlap. Meditations on emptiness in the Buddhist tradition seek to lead meditators to observe the ego as illusory and empty of inherent content as one step in the journey to liberate oneself from suffering. Conversely, dissociation is generally an involuntary, automatic response to severe trauma that can become more common or chronic in an individual over time. Topographically, these experiences may look similar; both include a sense of unreality of the self and often of the broader world. However, differences in stimulus …

Older Adults And Suicide As Examined Through The Lens Of Joiner's Interpersonal Theory Of Suicide, Pamela Holmes

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

Older adults face the highest rates of suicide of all age groups. The older adult population is not a homogenous group, and each age range—young old, middle old, and oldest old—has specific risk factors. Although Joiner’s interpersonal theory of suicide (IPTS) has been deemed valid among these age groups, it has not been specifically researched in older adults in each older age range. Due to lack of research and low reporting rates, not enough is known to develop specific detection and prevention measures targeting this population. This paper addresses the application of Joiner’s IPTS to both genders in each of …

Cancer Related Cognitive Impairment In Breast Cancer Patients: Guidelines For Neuropsychological Evaluation And Management, Ali Al-Humadi

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

Current literature indicates there is still some debate regarding the scope and severity of cancer treatment related cognitive impairment (CRCI), with a wide variety of complex factors contributing to cognitive decline and discrepancies between objective findings and patient self-report. This paper aims to provide guidelines for neuropsychological evaluation, management, and rehabilitation of CRCI in breast cancer patients based on current research. This paper also aims to discuss current research on proposed mechanisms of action for CRCI, the cognitive domains affected in CRCI, and significant bio-psycho-social risk factors impacting CRCI.

Attachment Theory To Inform Intervention In Correctional Populations With Adverse Childhood Experiences And Substance Use Disorders, Samantha Mendoza

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

Research shows a correlation exists between Adverse Childhood Experiences (ACEs) and poor mental health such as psychiatric and substance use disorders (Adshead, 2018). Research further suggests a correlation between ACEs and insecure attachment in adults (Adshead, 2018). The National Institute on Drug Abuse (2020) estimates 85% of the correctional population either has a substance use disorder or was incarcerated for a drug-related offense. This paper theorizes that those involved in the correctional system with a history of high ACE scores and substance use also experience insecure attachment, which is not currently addressed in correctional SUD programs. Attachment theory moderates the …

Asexuality And Demisexuality: Clinical Implications Of Sexual Identity, Michael Scott Fiorini

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

This paper considers demisexuality as an identity and sexual orientation for use by psychologists using historical, sociological, and psychological perspectives. It discusses the clinical implications of demisexuality as an identity and orientation distinct from asexuality. The paper discusses applications and limitations of defining and identifying demisexuality in a clinical population and it's social, scientific, and contextual significance. The paper compares what can be observed with existing diagnostic guidelines present in the DSM-5 for the identification of Female Sexual Interest/Arousal Disorder (FSIAD) and Male Hypoactive Sexual Desire Disorder (MHSDD). The paper proposes guidelines for the diagnosis and the ethical clinical treatment …

Working With Families With Refugee Experiences In The United States: The Impact Of Forced Displacement On Parent-Child Relationships After Resettlement, Sakshi Kapur

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

Refugees resettled in high-income countries like the United States have a unique set of challenges ranging from great psychological disturbance to acculturation challenges. With recent changes to policies related to immigration and refugee resettlement in the United States after the 2016 presidential elections, the refugee diaspora was left with resettlement services focused more on ensuring national security and economic independence rather than services that catered to re-integration beyond economics like acculturation stress, family functioning, and cultural adjustment. This systemic literature review explores the impact of forced displacement and migration on individuals, with an emphasis on family systems and parent-child relationships. …

"Stay Strong": Internalized Stigma, Religiosity And Black Mental Health In Colorado, Breigh Jones-Coplin

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

While the societal stigma on mental illness deters people from seeking mental health services, there is limited research on how Black personality and cultural practices may impact stigma and Black mental health (NAMI, 2020). In an attempt to identify protective and risk factors for internalized stigma and Black mental health, the present study examined 416 Black adults in Colorado and identified significant relationships between African Self-Consciousness, internalized stigma of mental illness, religiosity, and mental health functioning. Results showed that having a strong African-centered identity and religious grounding are associated with less internalized stigma and difficulty in functioning and mental health …

Reconstructing Neural Circuits Using Multiresolution Correlated Light And Electron Microscopy, Karl Friedrichsen, Pratyush Ramakrishna, Jen-Chun Hsiang, Katia Valkova, Daniel Kerschensteiner, Josh L Morgan

2020-Current year OA Pubs

Correlated light and electron microscopy (CLEM) can be used to combine functional and molecular characterizations of neurons with detailed anatomical maps of their synaptic organization. Here we describe a multiresolution approach to CLEM (mrCLEM) that efficiently targets electron microscopy (EM) imaging to optically characterized cells while maintaining optimal tissue preparation for high-throughput EM reconstruction. This approach hinges on the ease with which arrays of sections collected on a solid substrate can be repeatedly imaged at different scales using scanning electron microscopy. We match this multiresolution EM imaging with multiresolution confocal mapping of the aldehyde-fixed tissue. Features visible in lower resolution …

The Impact Of Sexual Abuse On Children, Alina M. Baltazar

Faculty Publications

No abstract provided.

Artificial Intelligence (Ai): The New Look Of Customer Service In A Cybersecurity World, Sharon L. Burton

Publications

Cybersecurity leaders are not adequately developed to guide the re-engineering of quality customer service (QCS) workflows, designed with automation and AI, that interrelate with people through customers’ perceptions. Realizing re-engineering processes should be a team effort with well-versed leadership and stakeholders guiding the successful design through a follow-up process. Leaders must shape compelling and straightforward needs to learn and teach employees and chat boxes indispensable customer service skills demonstrating patience, self-discipline, flexibility, and resourcefulness in communication with irritated customers or difficult circumstances. Whether the analysis, design, development, and implementation struggles are vacuums in cybersecurity knowledge, skill, and abilities or a …

Permitting Seaweed Cultivation For Carbon Sequestration In California: Barriers And Recommendations, Korey Silverman-Roati, Romany M. Webb, Michael B. Gerrard

Faculty Scholarship

Interest is growing in seaweed cultivation and sequestration as a carbon dioxide removal strategy. This white paper explores the barriers to seaweed permitting for carbon sequestration in California, including a complex, costly, and time-consuming lease and permitting process. Other states in the U.S., namely Maine and Alaska, have permitting systems designed to be more supportive of seaweed cultivation. This paper describes the legal framework for seaweed cultivation permitting in California and discusses the permitting systems in Maine and Alaska. The paper then explores possible reforms to streamline California’s permitting process, while maintaining appropriate environmental and other safeguards.

Perception Of Narcissism In College Professors, Harry M. Wallace, A. Carrillo, Jack Kelley

Psychology Faculty Research

We conducted three studies to examine perceptions of grandiose narcissism in college professors. Narcissism might appear incompatible with the profession if professors are viewed fundamentally as helpers or as introverted bookworms. Then again, people might expect professors to display big egos congruent with the prestige of their profession and their privileged public platforms. Our research indicates that professors are generally not seen as highly narcissistic according to the criteria of the Narcissistic Personality Inventory and the Narcissistic Admiration and Rivalry Questionnaire, though they are viewed as more narcissistic than elementary school teachers. More professor narcissism was expected at colleges that …

Approvals And Timing Of New Formulations Of Novel Drugs Approved By The Us Food And Drug Administration Between 1995 And 2010 And Followed Through 2021, Ravi Gupta, Christopher J. Morten, Angela J. Zhu, Reshma Ramachandran, Nilay D. Shah, Joseph S. Ross

Faculty Scholarship

New formulations of prescription drugs can improve convenience and tolerability for patients, but they also constitute manufacturer strategies to extend brand-name drug market exclusivity periods. We examined whether new formulations of brand-name novel drugs were associated with novel drugs’ sales and/or therapeutic value, as well as characterized first new formulations’ approval timing relative to the novel drug’s generic approval. We found that manufacturers are several times more likely to secure Food and Drug Administration approval for a new formulation for existing drugs that have reached blockbuster status. (Blockbuster drugs are the most profitable drugs with more than $1 billion in …

Creating A Strong Legal Preference For Kinship Care, Joshua Gupta-Kagan

Faculty Scholarship

One new to our field would be forgiven for thinking that the law must favor placing foster children with kin rather than with strangers. After all, individuals and organizations from across the ideological spectrum endorse kinship care, government publications describe kinship care as “the preferred resource” for placing children who cannot live at home with a parent and, after steady increases over multiple decades, authorities now place more than one-third of all foster children with kin. And decades of evidence establish that kinship care is generally more stable and serves children’s health and well-being better than living with strangers, a …

A Qualitative Study Exploring The Impact Of Anxiety On The Sibling Relationship, Maria Hays

PCOM Psychology Dissertations

Sibling relationships are one of the most critical elements of interpersonal functioning for children. The sibling relationship has been found to be an important foundation for the development of relationships in general, as siblings spend more time together than with anyone else. Mental health of a sibling has been found to impact the quality of the relationship; however, although anxiety is one of the most prevalent mental health disorders in children, there is a dearth of literature on its impact on the sibling relationship. The purpose of this study was to determine the perceptions siblings have about their experiences of …

Verification Dilemmas In Law And The Promise Of Zero-Knowledge Proofs, Kenneth A. Bamberger, Ron Canetti, Shafi Goldwasser, Evan J. Zimmerman

Faculty Scholarship

Individuals who wish to access a website or qualify for a loan are expected to expose personally identifying information, undermining their privacy and security. Firms share proprietary information in dealmaking negotiations which, if the deal fails, may be used by the negotiating partner for a competitive advantage. Regulators are expected to disclose their algorithmic tools to comply with public transparency and oversight requirements, a practice that risks rendering these tools circumventable and ineffective. Litigants might have to reveal trade secrets in court proceedings to prove a claim or defense. Such “verification dilemmas” — costly choices between opportunities that require the …

Investigating Environmetal Justice Education In Rural, Title 1 Stem Classrooms, Luis Prado

Research Papers

No abstract provided.

Loss Of Mmr And Tgfbr2 Increases The Susceptibility To Microbiota-Dependent Inflammation-Associated Colon Cancer, Elena Tosti, Ana S Almeida, Tam T T Tran, Mariel Barbachan E Silva, Pilib Ó Broin, Robert Dubin, Ken Chen, Amanda P Beck, Andrew S Mclellan, Eduardo Vilar, Aaron Golden, Paul W O'Toole, Winfried Edelmann

Faculty, Staff and Student Publications

Background and aims: Mutations in DNA mismatch repair (MMR) genes are causative in Lynch syndrome and a significant proportion of sporadic colorectal cancers (CRCs). MMR-deficient (dMMR) CRCs display increased mutation rates, with mutations frequently accumulating at short repetitive DNA sequences throughout the genome (microsatellite instability). The TGFBR2 gene is one of the most frequently mutated genes in dMMR CRCs. Therefore, we generated an animal model to study how the loss of both TGFBR2 signaling impacts dMMR-driven intestinal tumorigenesis in vivo and explore the impact of the gut microbiota.

Methods: We generated VCMsh2/Tgfbr2 mice in which Msh2loxP and Tgfbr2loxP alleles are …

Recent Advances On Dna Base Flipping: A General Mechanism For Writing, Reading, And Erasing Dna Modifications, Ren Ren, John R Horton, Samuel Hong, Xiaodong Cheng

Faculty, Staff and Student Publications

The modification of DNA bases is a classic hallmark of epigenetics. Four forms of modified cytosine-5-methylcytosine, 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine-have been discovered in eukaryotic DNA. In addition to cytosine carbon-5 modifications, cytosine and adenine methylated in the exocyclic amine-N4-methylcytosine and N6-methyladenine-are other modified DNA bases discovered even earlier. Each modified base can be considered a distinct epigenetic signal with broader biological implications beyond simple chemical changes. Since 1994, several crystal structures of proteins and enzymes involved in writing, reading, and erasing modified bases have become available. Here, we present a structural synopsis of writers, readers, and erasers of the modified …

A Phase I, Open-Label, Dose-Escalation Study Of The Ox40 Agonist Ivuxolimab In Patients With Locally Advanced Or Metastatic Cancers, Adi Diab, Omid Hamid, John A Thompson, Willeke Ros, Ferry A L M Eskens, Toshihiko Doi, Siwen Hu-Lieskovan, Samuel J Klempner, Bishu Ganguly, Catherine Fleener, Xiao Wang, Tenshang Joh, Ken Liao, Shahram Salek-Ardakani, Carrie Turich Taylor, Jeffrey Chou, Anthony B El-Khoueiry

Faculty, Staff and Student Publications

PURPOSE: Stimulation of effector T cells is an appealing immunotherapeutic approach in oncology. OX40 (CD134) is a costimulatory receptor expressed on activated CD4

PATIENTS AND METHODS: Adult patients (

RESULTS: The most common all-causality adverse events were fatigue (46.2%), nausea (28.8%), and decreased appetite (25.0%). Of 31 treatment-related adverse events, 30 (96.8%) were grade ≤2. No dose-limiting toxicities occurred. Ivuxolimab exposure increased in a dose-proportionate manner from 0.3 to 10 mg/kg. Full peripheral blood target engagement occurred at ≥0.3 mg/kg. Three (5.8%) patients achieved a partial response, and disease control was achieved in 56% of patients. Increased CD4

CONCLUSIONS: Ivuxolimab …

Cell-Directed Aptamer Therapeutic Targeting For Cancers Including Those Within The Central Nervous System, Jun Wei, Renduo Song, Aria Sabbagh, Anantha Marisetty, Neal Shukla, Dexing Fang, Hinda Najem, Martina Ott, James Long, Lijie Zhai, Maciej S Lesniak, Charles David James, Leonidas Platanias, Michael Curran, Amy B Heimberger

Faculty, Staff and Student Publications

Osteopontin (OPN) is produced by tumor cells as well as by myeloid cells and is enriched in the tumor microenvironment (TME) of many cancers. Given the roles of OPN in tumor progression and immune suppression, we hypothesized that targeting OPN with aptamers that have high affinity and specificity could be a promising therapeutic strategy. Bi-specific aptamers targeting ligands for cellular internalization were conjugated to siRNAs to suppress OPN were created, and therapeutic leads were selected based on target engagement and

Comparison Of Psma-Based 18f-Dcfpyl Pet/Ct And Pelvic Multiparametric Mri For Lesion Detection In The Pelvis In Patients With Prostate Cancer, Trinh T Nguyen, Priya R Bhosale, Guofan Xu, Tinsu Pan, Peng Wei, Yang Lu

Faculty, Staff and Student Publications

Purpose: To directly compare the performance of pelvic mpMRI versus recently approved and increasingly used PSMA-based 18F-DCFPyL PET/CT in intermediate-high risk and biochemical recurrent prostate cancer patient cohort while exploring their potential differing applications in specific clinical scenarios.

Methods: A retrospective analysis was performed on patients who had 18F-DCFPyL PET/CT and pelvic mpMRI done from September 2021 to January 2022 at a single institution. The inclusion criteria were paired exams within a 3-month interval. Exclusion criteria were intervening treatment between exams, a change in PSA by more than 50% and absolute difference more than 1 ng/mL, or concurrent history of …

A Yeast Model For Trichohepatoenteric Syndrome Suggests Strong Loss Of Ski2 Function In Most Causative Mutations, Luisa J Orlando, Matthew K Yim, Thomson Hallmark, Michael Cotner, Sean J Johnson, Ambro Van Hoof

Faculty, Staff and Student Publications

The intestinal and immune disorder trichohepatoenteric syndrome (THES) is characterized by mutations in human Ski2 and Ski3, also known as SKIV2L and TTC37, respectively. The mechanism by which these mutations leads to the immunodeficiency, chronic diarrhea, failure to thrive and liver disease associated with THES is unknown. To what degree THES patient mutations in Ski2 affect Ski2 function and how the differences in Ski2 function could lead to varying patient outcomes has not been studied. Here, we assayed function of THES ski2 mutants in the yeast homolog. Our results show that most THES patient mutations cause severe dysfunction in Ski2. …

An Autoencoder-Based Deep Learning Method For Genotype Imputation, Meng Song, Jonathan Greenbaum, Joseph Luttrell, Weihua Zhou, Chong Wu, Zhe Luo, Chuan Qiu, Lan Juan Zhao, Kuan-Jui Su, Qing Tian, Hui Shen, Huixiao Hong, Ping Gong, Xinghua Shi, Hong-Wen Deng, Chaoyang Zhang

Faculty, Staff and Student Publications

Genotype imputation has a wide range of applications in genome-wide association study (GWAS), including increasing the statistical power of association tests, discovering trait-associated loci in meta-analyses, and prioritizing causal variants with fine-mapping. In recent years, deep learning (DL) based methods, such as sparse convolutional denoising autoencoder (SCDA), have been developed for genotype imputation. However, it remains a challenging task to optimize the learning process in DL-based methods to achieve high imputation accuracy. To address this challenge, we have developed a convolutional autoencoder (AE) model for genotype imputation and implemented a customized training loop by modifying the training process with a …

Recurrent Hgnet-Mn1 Altered (Astroblastoma Mn1-Altered) Of The Foramen Magnum: Case Report And Molecular Classification, Sricharan Gopakumar, Malcolm F Mcdonald, Himanshu Sharma, Claudio E Tatsui, Gregory N Fuller, Ganesh Rao

Faculty, Staff and Student Publications

Background: Astroblastoma is a rare primary brain tumor of unclear origin, often occurring in young patients less than 30-years-old. It typically arises supratentorially and is diagnosed based on histological features including vascular hyalinization and perivascular pseudorosettes. Recent molecular characterization of primary CNS high-grade neuroepithelial tumors with meningioma I alteration (HGNET-MN1) found that HGNET-MN1 and tumors with morphological signatures of astroblastoma clustered together. Further analysis revealed such astroblastomas have MN1 alteration and the 2021 WHO classification of tumors of the CNS now recognizes astroblastoma MN1-altered as a new entity.

Case description: Here, we present the case of …

Creating An Arcgis Dashboard For Climate Data Management And Visualization, Sydney Noel Case

Senior Independent Study Theses

The College of Wooster Department of Earth Sciences has collected over the past 12 years (and continues to collect) hourly local climate indicator data including stream level and temperature, air temperature and pressure, precipitation levels, and relative humidity. This data is collected at the College’s research station, Fern Valley, located in Holmes County, Ohio and serves as a storytelling component for regional climate change. Upon initial investigation, the extensive dataset revealed a fundamental data storage problem within Earth Sciences, as there lacked a singular location to store complex datasets. Several technological solutions were explored to create a long-term data storage, …