Digital Commons Network^™

Unlocking The Functional Potential Of Polyploid Yeasts, Simone Mozzachiodi, Kristoffer Krogerus, Brian Gibson, Alain Nicolas, Gianni Liti

Research Outputs: 2025-Present

Breeding and domestication have generated widely exploited crops, animals and microbes. However, many Saccharomyces cerevisiae industrial strains have complex polyploid genomes and are sterile, preventing genetic improvement strategies based on breeding. Here, we present a strain improvement approach based on the budding yeasts’ property to promote genetic recombination when meiosis is interrupted and cells return-to-mitotic-growth (RTG). We demonstrate that two unrelated sterile industrial strains with complex triploid and tetraploid genomes are RTG-competent and develop a visual screening for easy and high-throughput identification of recombined RTG clones based on colony phenotypes. Sequencing of the evolved clones reveal unprecedented levels of RTG-induced …

Prefrontal Glutamate Neurotransmission In Ptsd: A Novel Approach To Estimate Synaptic Strength In Vivo In Humans, Lynnette A Averill, Lihong Jiang, Prerana Purohit, Anastasia Coppoli, Christopher L Averill, Jeremy Roscoe, Benjamin Kelmendi, Henk M De Feyter, Robin A De Graaf, Ralitza Gueorguieva, Gerard Sanacora, John H Krystal, Douglas L Rothman, Graeme F Mason, Chadi G Abdallah

Staff and Researcher Publications

Background: Trauma and chronic stress are believed to induce and exacerbate psychopathology by disrupting glutamate synaptic strength. However, in vivo in human methods to estimate synaptic strength are limited. In this study, we established a novel putative biomarker of glutamatergic synaptic strength, termed energy-per-cycle (EPC). Then, we used EPC to investigate the role of prefrontal neurotransmission in trauma-related psychopathology.

Methods: Healthy controls (n = 18) and patients with posttraumatic stress (PTSD; n = 16) completed 13C-acetate magnetic resonance spectroscopy (MRS) scans to estimate prefrontal EPC, which is the ratio of neuronal energetic needs per glutamate neurotransmission cycle (VTCA/VCycle).

Results: Patients …

Turning Data Into Better Mental Health: Past, Present, And Future, Nidal Moukaddam, Akane Sano, Ramiro Salas, Zakia Hammal, Ashutosh Sabharwal

Staff and Researcher Publications

In this mini-review, we discuss the fundamentals of using technology in mental health diagnosis and tracking. We highlight those principles using two clinical concepts: (1) cravings and relapse in the context of addictive disorders and (2) anhedonia in the context of depression. This manuscript is useful for both clinicians wanting to understand the scope of technology use in psychiatry and for computer scientists and engineers wishing to assess psychiatric frameworks useful for diagnosis and treatment. The increase in smartphone ownership and internet connectivity, as well as the accelerated development of wearable devices, have made the observation and analysis of human …

Fatigue Risk Management: Current Practices And Challenges, Further Learning, Ishbel Macgregor-Curtin, Nora Balfe, Maria Chiara Leva

Research Outputs: 2025-Present

This paper outlines the causes, consequences and prevalence of fatigue and demonstrates the risk fatigue plays in accident causation in safety critical transport industries. Approaches to fatigue risk management are described and the limitations and challenges of these approaches are discussed in the context of the transport industry. The paper expands on previous research by further analysing data from a benchmarking study to determine the approaches taken in the rail industry. The paper concludes that railway organisations are applying some elements of a Fatigue Risk Management System (FRMS) approach to fatigue management, but this is not being applied systematically which …

Dataset Of Parent-Child Hyperscanning Functional Near-Infrared Spectroscopy Recordings, Andrea Bizzego, Giulio Gabrieli, Atiqah Azhari, Mengyu Lim, Gianluca Esposito

Research Outputs: 2025-Present

The term “hyperscanning” refers to the simultaneous recording of multiple individuals’ brain activity. As a methodology, hyperscanning allows the investigation of brain-to-brain synchrony. Despite being a promising technique, there is a limited number of publicly available functional Near-infrared Spectroscopy (fNIRS) hyperscanning recordings. In this paper, we report a dataset of fNIRS recordings from the prefrontal cortical (PFC) activity of 33 mother-child dyads and 29 father-child dyads. Data was recorded while the parent-child dyads participated in an experiment with two sessions: a passive video attention task and a free play session. Dyadic metadata, parental psychological traits, behavioural annotations of the play …

To Wine Or Not To Wine? A Scientometric Approach To 65+ Years Of Wine Preference And Selection Studies, Alessandro Carollo, Seraphina Fong, Giulio Gabrieli, Claudio Mulatti, Gianluca Esposito

Research Outputs: 2025-Present

Purpose: Among the growing interest towards market segmentation and targeted marketing, the current study adopted a scientometric approach to examine the literature on wine selection and preferences. The current review specifically attempts to shed light on the research that explores the determinants of wine preferences at multiple levels of analysis. Design/methodology/approach: CiteSpace was used to compute a Document Co-Citation Analysis (DCA) on a sample of 114,048 eligible references obtained from 2,846 publications downloaded from Scopus on 24 May 2021. Findings: An optimized network of 1,505 nodes and 4,616 links was generated. Within the network, impactful publications on the topic and …

Harmonising The Human Biobanking Consent Process: An Irish Experience, Lydia O'Sullivan, Tomás P. Carroll, Niamh Clarke, Sarah Cooper, Ann Cullen, Laura Gorman, Billy Mccann, Blánaid Mee, Nicola Miller, Verena Murphy, Máiréad Murray, Jackie O'Leary, Sharon O'Toole, Emma Snapes, Suzanne Bracken

Research Outputs: 2025-Present

Biobanks are repositories of human biological samples and data. They are an important component of clinical research in many disease areas and often represent the first step toward innovative treatments. For biobanks to operate, researchers need human participants to give their samples and associated health data. In Ireland, research participants must provide their freely given informed consent for their samples and data to be taken and used for research purposes. Biobank staff are responsible for communicating the relevant information to participants prior to obtaining their consent, and this communication process is supported by the Participant Information Leaflets and Informed Consent …

Rice Tolerance To Multiple Applications Of Florpyrauxifen-Benzyl Alone And Followed By Benzobicyclon, James Winston Beesinger, Jason K. Norsworthy, Thomas R. Butts, Trenton Roberts

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Varying levels of sensitivity to florpyrauxifen-benzyl and benzobicyclon applications among rice (Oryza sativa L.) cultivars have been observed. The safe use of florpyrauxifen-benzyl and benzobicyclon in the same herbicide program could provide broad-spectrum weed control and delay resistance in weed species. Two experiments were conducted in 2019 and 2020 near Stuttgart, AR, to test cultivars' sensitivity to multiple rates of florpyrauxifen-benzyl and applications of florpyrauxifen-benzyl followed by benzobicyclon. The first experiment was designed to determine the sensitivity of the rice cultivars `XP753', 'CL XL745', 'Gemini 214CL', 'Titan', and 'Diamond' to applications of florpyrauxifen-benzyl at 0.03 and 0.06 lb acid …

Visual Oscillation Effects On Dynamic Balance Control In People With Multiple Sclerosis, Lara I. Riem, Scott A. Beardsley, Ahmed Z. Obeidat, Brian D. Schmit

Biomedical Engineering Faculty Research and Publications

Background: People with multiple sclerosis (PwMS) have balance deficits while ambulating through environments that contain moving objects or visual manipulations to perceived self-motion. However, their ability to parse object from self-movement has not been explored. The purpose of this research was to examine the effect of medial-lateral oscillations of the visual field and of objects within the scene on gait in PwMS and healthy age-matched controls using virtual reality (VR).

Methods: Fourteen PwMS (mean age 49 ± 11 years) and eleven healthy controls (mean age: 53 ± 12 years) participated in this study. Dynamic balance control was assessed while participants …

Multi-Criteria Decision Analysis For Evaluation Of Potential Renewable Energy Resources In Malaysia, Zul Ilham

Research Publications (2021 to 2025)

Switching to renewable energy resources as an alternative is critical for developing countries in order to ensure energy security and diversify their energy supply. Malaysia is endowed with biomass, solar, waste-to-energy, wind, and hydro energy potentials, although these have not been fully explored. This is because the country continues to rely extensively on conventional fossil-fuel energy sources such as coal and petroleum to generate power and consume energy. On the other hand, demand for energy is increasing as a result of population growth and a booming economy. Thus, this study intends to identify suitable potential renewable energy resources that can …

Reaction Cross-Section For Nuclear Halo-Targets And Lighter Mass Projectiles Using The Relativistic Mean-Field Approach, Monalisa Das, N. Biswal, R. N. Panda, Joshua T. Majekodunmi, Mrutunjaya Bhuyan

Research Publications (2021 to 2025)

No abstract provided.

Defending Human Difference By Raising The Bar, Joe Gough

Animal Sentience

Chapman & Huffman (C&H) offer a theory of why we humans want to believe that we are different: to justify our cruelty to animals. This commentary offers further supporting evidence of this and examines more closely what the claim that humans are ‘different’ amounts to. It also considers some methodological issues in animal psychology closely related to C&H ‘s theory. These problems result from a common strategy for defending hypotheses about human difference.

Judith S. Kaye: A Chief Judge For Families And Children, Andrew Shepard

Hofstra Law Faculty Scholarship

No abstract provided.

Choosing Death, Shaping Death: Assumptions About Disabilities, Race, And Death, Janet L. Dolgin

Hofstra Law Faculty Scholarship

This article considers two legal cases and the stories that developed around them. Both the cases and their stories involved issues of significance to the larger society - death and bias. Each concern has occasioned confusion and debate in its own right. When these issues are combined, confusion and debate are intensified. This Article examines the complicated interplay between bias and decisions about death and dying in the U.S. health care system. Further, it reviews intersecting claims about the importance, respectively, of autonomy and community in resolving disputes about the topics of death and dying.

The Elephant In The Room In Clinical Scholarship: Ethical Guardrails And Case Histories, Theo Liebmann, Stefan H. Krieger

Hofstra Law Faculty Scholarship

Lawyers know how to tell a good story and are expected, encouraged, and even ethically required to use that skill on behalf of their clients. More and more, lawyers and legal academics are now using their clients' stories to advance goals that go far beyond achieving a client's objectives: exposing inequities with regard to access to justice; educating the public about the functioning and limitations of the legal system; raising the quality of lawyering; and improving our system of legal education. Unfortunately, the increase in the use of case histories to achieve such laudable goals has not been paired with …

The Thin Blue Line Between Virtue And Vice: Confronting The Moral Harms Of Policing, G. Alex Sinha

Hofstra Law Faculty Scholarship

Scholarship on policing has exploded in recent years as bystanders increasingly record and circulate videos of police brutality, much of it directed at civilians of color. These incidents have invited significant attention on the culture of police departments and police unions, generating widespread calls for the reform or even the abolition of police forces. The traditional considerations at the center of these debates include the practical challenges to enacting reforms, the expected efficacy of proposed changes for curtailing abuses, and the possible costs of these changes (whether measured in dollars or crime rates). The moral premises that are inherently embedded …

Sol-Gel Synthesis Of Zno Nanoparticles Using Different Chitosan Sources: Effects On Antibacterial Activity And Photocatalytic Degradation Of Azo Dye, Ilham Ben Amor, Hadia Hemmami, Salah Eddine Laouini, Mohammed Sadok Mahboub, Ahmed Barhoum

Research Outputs: 2025-Present

Chitosan was used in the sol-gel synthesis of zinc oxide nanoparticles (ZnO NPs) as a capping agent in order to control the size, morphology, optical bandgap, photocatalytic efficiency, and antimicrobial activity. Different chitosan sources were used for the sol-gel synthesis of ZnO NPs, namely chitosan of shrimp shells, crab shells, and Streptomyces griseus bacteria. The photocatalytic efficiency was studied by using the methylene blue (MB) photodegradation test, and the antibacterial activity of the different types of ZnO NPs was investigated by the agar well diffusion technique. The particle size of ZnO NPs varied between 20 and 80 nm, and the …

Granulated Organoclay As A Sorbent To Protect The Allelochemical Scopoletin From Rapid Biodegradation In Soil, Jose Antonio Galán-Pérez, Beatriz Gámiz, Rafael Celis

Research Outputs: 2025-Present

Allelochemicals have been proposed as environmentally friendly bioherbicides, but their short persistence in soils often limits their performance as natural weed management products. In this study, incorporation into organoclay granules was investigated as a strategy to protect the allelochemical scopoletin from rapid biodegradation and prolong its persistence in soil. The commercial organoclay Cloisite® 10A, in its raw powder form, was used to prepare the granules. A kinetic study revealed slower sorption of scopoletin on the granules than on the organoclay powder and indicated an intraparticle pore diffusion mechanism. The half-life of scopoletin in soil under laboratory conditions increased significantly by …

Post-Grant Adjudication Of Drug Patents: Agency And/Or Court?, Arti K. Rai, Saurabh Vishnubhakat, Jorge Lemus, Erik Hovenkamp

Articles

The America Invents Act of 2011 (AIA) created a robust administrative system-the Patent Trial and Appeal Board (PTAB)-that provides a route for challenging the validity of granted patents outside of district courts. Congress determined that administrative adjudication of the validity of initial patent grants could be cheaper and more scientifically accurate than district court adjudication of such validity.

For private economic value per patent, few areas of technology can match the biopharmaceutical industry. This is particularly true for small-molecule drugs. A billion-dollar drug monopoly may be protected from competition by a relatively small number of patents. Accordingly, the social cost …

Discussion On The Application Of Dispute Settlement Mechanism Of The 1982 United Nations Convention On The Law Of The Sea To The Thai - Myanmar Maritime Dispute, Yodsapon Nitiruchirot

Asian Review

This qualitative research study aims to examine theThai-Myanmar maritimedispute,applying the dispute settlement mechanism of the 1982 United Nations Convention on theLaw of the Sea (UNCLOS). The research methodology includes documentary research and in-depth interview. After analyzing data collected,itis found that the dispute settlement mechanismof the UNCLOS comprises voluntary and compulsory procedures. As both Thailand and Myanmarare parties to the UNCLOS and their dispute involves an area in the Andaman Sea, thoseprocedures may be applied. Thecompulsory procedure may be applied with some issues, but notthe territorial dispute and the boundary delimitation dispute. Therefore, there are few benefits togain from the procedure. …

Preliminary Study And First Evidence Of Presence Of Microplastics In Green Mussel, Perna Viridis From Phuket, Phaothep Cherdsukjai, Vararin Vongpanich, Pensiri Akkajit

Applied Environmental Research

Plastics can reach the coastal environment and could impact the marine environment. Mussels are marine organisms which are prone to be exposed to microplastics pollution. Therefore, in this preliminary study, the commercially important green mussel (Perna viridis) collected at the Koh Phee Canal in Phuket, Phuket Province, southern peninsular Thailand, was investigated. The collected mussels from aquaculture farm fell into three age groups, namely 1 year-1 month, 1 year-7 months, and 1 year-9 months. Results from the investigation showed 200 items of microplastics present in Perna viridis with 76 items (38%) in flushed water and 124 items (62%) …

Assessment Of Organophosphorus Pesticide Residues In Water And Sediment Collected From The Southern Caspian Sea, Reza Golshani, Ghasem Ghorbanzadeh Zafarani, Maksim Rebezov, Samaneh Karbalaei, Tony R. Walker

Applied Environmental Research

Pollution of water resources by uncontrolled pesticide use is a serious health and environmental issue. In this study, concentrations of three organophosphorus pesticides (diazinon, malathion, and azinphos-methyl) in water and sediment samples from five estuaries (Sefidrud, Chalus, Babolrud, Tajan, and Gorganrud) along the Caspian Sea were investigated. Samples were collected from surface water and sediment during summer to autumn, and pesticides were analysed by gas chromatography-mass spectrometry (GC-MS). Results indicated that salinity and turbidity in Gorganrud were higher (salinity: range 2–8%; turbidity: range 1–9%) compared to other stations. Higher diazinon (water: 0.08±0.06, sediment: 0.04±0.01), malathion (water: 0.09±0.06, sediment: 0.05±0.01) and …

Performance Of Porous Substrates For Domestic Wastewater Treatment Under Prolonged Hydraulic Retention Time, Pakawat Janyasupab, Arunothai Jampeetong

Applied Environmental Research

Physicochemical characteristics of porous substrates (longan biochar, corn biochar, and pumice) including specific surface area (SSA), pore volume (Vp), and cation exchange capacity (CEC) were determined. Longan biochar had the highest SSA, Vp, and CEC, followed by corn biochar and pumice. Then, columns filled with each of these 3 substrates together with gravel as a control treatment, were evaluated to compare wastewater treatment efficiency under different hydraulic retention times (HRTs). Each system had been acclimatized with wastewater for 8 weeks. Then, influent and effluent were analyzed at 1, 3, 5, and 7 day intervals. Water analysis revealed that biochar-based systems …

Spatial Distribution Of Bioavailable Metal Concentrations And Total Metal Concentration-Depth Relationship Along The Sediment Profile Within Phuket Bay, Pensiri Akkajit, Danai Tipmanee, Kaimook Jaileak

Applied Environmental Research

Heavy metals in coastal sediments can adversely affect human health and the environment. The distribution and metal bioavailability of Pb and Zn in 21 sediment samples collected from Phuket Bay, Phuket, Thailand using the first-two steps of sequential extraction proposed by the Standards, Measurements and Testing programme (known as BCR) was determined. The results showed that Pb formed weak complexes contributing up to 11.2% to 33% of its total concentration (1.7 to 7.5 mg kg-1) in the first fraction (BCR1), while Zn in the BCR1 fraction ranged from 4.9% to 9.9%. The results suggest that Pb could easily enter the …

Remedying Trait-Based Employment Discrimination: Lessons From The Crown Act, Tolulope Odunsi-Nelson

Faculty Scholarship

Trait discrimination is bias against people who possess traits and characteristics that are culturally, commonly, or historically associated with a particular race. Discrimination against Black people with "natural hairstyles" and anti-Black colorism are two forms of trait discrimination that stem from employers' preferences for white aesthetics. The CROWN Act is a law that expands the definition of race in discrimination laws to include an individual's hair texture or hairstyle, if that hair texture or hairstyle is commonly and/or historically associated with a particular race or national origin. The need for the CROWN Act stems from the systemic failure of United …

Raman Spectroscopy Reveals Phenotype Switches In Breast Cancer Metastasis, Santosh Kumar Paidi, Joel Rodriguez Troncoso, Mason G. Harper, Zhenhui Liu, Khue G. Nguyen, Sruthi Ravindranathan, Lisa Rebello, David E. Lee, Jesse D. Ivers, David A. Zaharoff, Narasimhan Rajaram, Ishan Barman

Biomedical Engineering Faculty Publications and Presentations

The accurate analytical characterization of metastatic phenotype at primary tumor diagnosis and its evolution with time are critical for controlling metastatic progression of cancer. Here, we report a label-free optical strategy using Raman spectroscopy and machine learning to identify distinct metastatic phenotypes observed in tumors formed by isogenic murine breast cancer cell lines of progressively increasing metastatic propensities. Methods: We employed the 4T1 isogenic panel of murine breast cancer cells to grow tumors of varying metastatic potential and acquired label-free spectra using a fiber probe-based portable Raman spectroscopy system. We used MCR-ALS and random forests classifiers to identify putative spectral …

Machine Learning Approaches To Improve Prediction In Health Care, Sadaf Kabir

Graduate Theses, Dissertations, and Problem Reports (ETD)

The availability of data and advanced data analysis tools in the health care domain provide great opportunities for the discovery of unknown or hidden patterns in clinical data. However, medical data is often incomplete and has poor quality, e.g., it contains missing values or too many unnecessary features. Majority of these issues are induced by uncertainty in clinical trials and examinations, such as human error, patients’ withdrawal during studies, malfunctioning of data collection equipment, and are generally inevitable. Properly addressing these issues can lead to the development of precise predictive models and consequently more reliable clinical decision making. Accurate predictive …

Knowledge And Training In Language Sample Analysis Of Us Speech-Language Pathology Graduate Students, Allegra Cornaglia

Graduate Theses, Dissertations, and Problem Reports (ETD)

Purpose: Speech-language pathologists (SLPs) play an integral role in identification and treatment of developmental language disorders (DLD). Best practices include the use of language sample analysis (LSA) as part of a comprehensive evaluation. However, LSA requires a specific set of foundational morphological and syntactic knowledge. Previous studies have shown a knowledge gap for both SLPs and SLP graduate students for other areas of morphosyntax and phonology. This study examined the language analysis skills of current SLP graduate students on a test of Mean Length of Utterance (MLU) analysis and Clausal Density (CD) and whether there were possible factors associated with …

Smallmouth Bass (Micropterus Dolomieu) Population Characteristics And An Evaluation Of Management Responses In Two West Virginia Watersheds, Jacob D. Harrell

Graduate Theses, Dissertations, and Problem Reports (ETD)

Smallmouth Bass (Micropterus dolomieu) population characteristics were examined within the Tygart and Cheat River watersheds of north-central West Virginia. Growth, mortality and recruitment were examined for each individual population prior to modeling potential effects of various management schemes. Smallmouth Bass were sampled for total length and weight, aged using sagittal otoliths and sexed through observations of gonadal or ovarian development. Growth for each population was examined using von Bertalanffy growth models and assessed for variation among populations. Population demographic characteristics differed between and among populations, most noticeably between riverine and lacustrine habitat, whereby growth, mortality and recruitment were higher …

Assessment Of The Geographic Distribution And Tools To Assist With Conservation Of Spotted Turtles (Clemmys Guttata) In West Virginia, Joel Leal Mota

Graduate Theses, Dissertations, and Problem Reports (ETD)

Turtles are one of the most globally threatened vertebrate groups, largely due to habitat loss, commercial exploitation, climate change, disease, and invasive species. In the United States, the spotted turtle (Clemmys guttata) is among over 50 amphibian and reptile species recently petitioned to be listed under the Endangered Species Act of 1973 (ESA). The U.S. Fish and Wildlife Service subsequently determined the spotted turtle to be a candidate species for listing. Historically, spotted turtles were known to occur at a few locations in the eastern panhandle region of West Virginia. However, previous attempts to determine the distributional extent …