Digital Commons Network^™

Safeguarding America’S “Unnatural” Guardians: How Georgia’S Legal Guardianship Statute Excludes “Atypical,” Matriarchal Familial Structures Rooted In Black Culture, Destiny B. Barnett

Georgia Law Review

The stereotypical American family is often seen as one man, one woman, and their child. However, this notion of the traditional family is changing. For centuries, familial matriarchs have assumed roles typically reserved for a child’s biological parents. Specifically, African American grandmothers, aunts, and other female figures have served as kinship caregivers for countless generations of children dating back to before the period of American slavery. These forgotten matriarchs, who often serve as the foundation of African American family units, have been historically abandoned by our universalist legal system that idolizes the nuclear concept of family and favors the retention …

Cognitive Performance Enhancement For Multi-Domain Operations, Daniel J. Herlihy

The US Army War College Quarterly: Parameters

Despite its desire to achieve cognitive dominance for multi-domain operations, the Army has yet to develop fully and adopt the concept of cognitive performance enhancement. This article provides a comprehensive assessment of the Army’s efforts in this area, explores increasing demands on soldier cognition, and compares the Army’s current approach to its adversaries. Its conclusions will help US military and policy practitioners establish the culture and behaviors that promote cognitive dominance and success across multiple domains.

A Patient-Specific Algorithm For Lung Segmentation In Chest Radiographs, Manawaduge Supun De Silva, Barath Narayanan Narayanan, Russell C. Hardie

Electrical and Computer Engineering Faculty Publications

Lung segmentation plays an important role in computer-aided detection and diagnosis using chest radiographs (CRs). Currently, the U-Net and DeepLabv3+ convolutional neural network architectures are widely used to perform CR lung segmentation. To boost performance, ensemble methods are often used, whereby probability map outputs from several networks operating on the same input image are averaged. However, not all networks perform adequately for any specific patient image, even if the average network performance is good. To address this, we present a novel multi-network ensemble method that employs a selector network. The selector network evaluates the segmentation outputs from several networks; on …

Chronic, Mild Hypothermic Environmental Temperature Does Not Ameliorate Cognitive Deficits In An Alzheimer's Disease Mouse., Samuel Mcfadden, Lindsey N Sime, Makayla F. Cox, Caleigh A Findley, Mackenzie R Peck, Kathleen Quinn, Yimin Fang, Andrzej Bartke, Erin R Hascup, Kevin N Hascup

Articles

Metabolic dysfunction increases with age and is a contributing factor to Alzheimer's disease (AD) development. We have previously observed impaired insulin sensitivity and glucose homeostasis in the APP/PS1 model of AD. To improve these parameters, we chronically exposed male and female mice to mild hypothermic environmental temperature (eT), which positively modulates metabolism. Although a hypothermic eT normalized insulin sensitivity, glucose tolerance was still impaired in both sexes of AD mice. We observed increased plasma glucagon and BAFF in both sexes, but additional sexually dimorphic mechanisms may explain the impaired glucose homeostasis in AD mice. Hepatic Glut2 was decreased in female …

November 18, 2022 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Irreparable Massive Rotator Cuff Tears: Subacromial Balloon Surgical Technique, Alexander J. Rondon, Dominic M. Farronato, Joshua D. Pezzulo, Joseph A. Abboud

Rothman Institute Papers

Massive irreparable rotator cuff tears pose a significant challenge for both the treating orthopedic surgeon and patient. Surgical treatment options for massive rotator cuff tears include arthroscopic debridement, biceps tenotomy or tenodesis, arthroscopic rotator cuff repair, partial rotator cuff repair, cuff augmentation, tendon transfers, superior capsular reconstruction, subacromial balloon spacer, and ultimately reverse shoulder arthroplasty. The present study will provide a brief overview of these treatment options along with a description of the surgical technique for subacromial balloon spacer placement.

Estimation Of Economic Risk From Coastal Natural Hazards In Louisiana, Rubayet Bin Mostafiz

LSU Doctoral Dissertations

Louisiana, U.S.A., is among the most vulnerable areas globally to coastal natural hazards, with risk vulnerability likely increasing. The risks associated with non-tropical-cyclone hazards in Louisiana’s coastal zone have been understudied. This research enhances present and future (i.e., 2050) Louisiana risk assessment using locally-weighted, model-based hazard frequency/intensity and population projections.

Results suggest that property risks associated with extreme cold temperature and tornado are and will remain costlier than those for hail and lightning. Property risks of extreme cold temperature and hail are projected to decrease with the expected warming temperatures, with those of all four of these hazards peaking in …

The Minutes Of The Marshall University Graduate Council Meeting, November 18, 2022, Marshall University Graduate Council

Graduate Council Minutes

No abstract provided.

2022 November 18 - Board Of Trustees Academic, Research, And Student Success Committee Agenda And Minutes, Board Of Trustees, East Tennessee State University

Board of Trustees Agendas and Minutes

No abstract provided.

Biomass Characterization And Insulation Optimization Studies, Hussein Awad Kurdi Saad

Doctoral Dissertations and Master's Theses

This study indicates how biomass materials can be effectively used as naturally sustainable alternatives to insulation materials. Barley grains and oak leaves, straw, and jute are collected, and crushed into powders/ chopped pieces. The physical characteristics are measured to characterize each powder. The biomass powder reinforced composites are manufactured in varying weight ratios. The density and thermal conductivity of composite materials are measured. The properties of composites compared to those of commercial insulation materials are found to be close to them. Furthermore, genetic algorithms (GA) can be used to achieve multi-objective optimization entailing maximizing insulation (minimizing heat transfer) and simultaneously …

Assessment And Risk Stratification Of Ageing-Related Target Organ Damage And Adverse Health Outcomes In The General Population, Jesus D. Melgarejo

School of Medicine Publications

The objectives of this doctoral thesis are to address the contribution of blood pressure to the presence of subclinical target-organ damage and the development of adverse health complications that associate with a poor life course of aging. This thesis focuses on ambulatory blood pressure monitoring to provide the most accurate information about the blood pressure level and variability over a 24-hour period. Moreover, by investigating the role of novel markers, including imaging markers and biomarkers, this thesis also provides possible pathophysiological and biological mechanisms that might explain the association between vascular risk factors and adverse health complications. We envisage that …

Present Danger: Nuclear Power Plants In War, Henry D. Sokolski

The US Army War College Quarterly: Parameters

After Russia’s unprecedented seizure of Ukraine’s nuclear plant at Zaporizhzhya, the United States needs to adjust its military planning and policies to cope with hostile military forces’ targeting, seizure, and garrisoning of armed forces at large, operating nuclear plants and clarify its policies regarding possible US targeting of such plants. This article is the first to analyze these concerns. It compares Russia’s assaults with previous strikes against research reactors and nonoperating nuclear plants in the Middle East and clarifies what new military measures and policies will be needed to cope with military operations against large, operating nuclear plants. US Army …

A Review Of Psilochalcis Kieffer (Hymenoptera: Chalcidoidea: Chalcididae) From The Western United States With Descriptions Of Three New Species From Utah And Surrounding States, Mark J. Petersen, Robert L. Johnson, Val Jo Anderson

Western North American Naturalist

A review of Psilochalcis Kieffer (Hymenoptera: Chalcididae) species in the western United States is presented, with the addition of 3 new species: Psilochalcis adenticulata Petersen, new species; Psilochalcis minuta Petersen, new species; and Psilochalcis quadratis Petersen, new species. Morphological diagnoses and distributions are given for each species. A dichotomous key to the Psilochalcis species of North America is presented.


Se presenta una revisión de las especies de Psilochalcis Kieffer (Hymenoptera: Chalcididae) en el oeste de los Estados Unidos, con la incorporación de tres nuevas especies: una nueva especie de Psilochalcis adenticulata Petersen, una nueva especie de Psilochalcis minuta Petersen y …

The History Of Cougars In Yellowstone National Park, William J. Ripple Phd, Robert L. Beschta, Luke E. Painter

Western North American Naturalist

We synthesize reports of cougar (Puma concolor) killings, sightings, and related information in Yellowstone National Park from the early 1900s through the 1970s. Cougars were common before the park was established in 1872 but were heavily persecuted in the late 1800s and early 1900s, when the park attempted extirpation. Despite being greatly reduced, cougars may have persisted, at least intermittently, in the park and vicinity at low levels from the 1920s through the 1950s, at numbers that were likely functionally irrelevant from an ecological perspective. More recently, in field studies conducted during periods between 1987 and 2017, cougar …

Parameters Winter Issue 2022-23, Usawc Press

The US Army War College Quarterly: Parameters

No abstract provided.

Variational And Phase Response Analysis For Limit Cycles With Hard Boundaries, With Applications To Neuromechanical Control Problems, Jeffery P. Gill, Hillel J. Chiel, Peter J. Thomas, Peter J. Thomas

Faculty Scholarship

Motor systems show an overall robustness, but because they are highly nonlinear, understanding how they achieve robustness is difficult. In many rhythmic systems, robustness against perturbations involves response of both the shape and the timing of the trajectory. This makes the study of robustness even more challenging. To understand how a motor system produces robust behaviors in a variable environment, we consider a neuromechanical model of motor patterns in the feeding apparatus of the marine mollusk Aplysia californica (Shaw et al. in J Comput Neurosci 38(1):25–51, 2015; Lyttle et al. in Biol Cybern 111(1):25–47, 2017). We established in (Wang et …

A Single Amino Acid Substitution In Porcine Reproductive And Respiratory Syndrome Virus Glycoprotein 2 Significantly Impairs Its Infectivity In Macrophages, Jayeshbhai Chaudhari, Raquel Arruda Leme, Kassandra Durazo-Martinez, Sarah Vitosh-Sillman, Aspen M. Workman, Hiep Vu

Nebraska Center for Virology: Faculty Publications

Porcine reproductive and respiratory syndrome virus (PRRSV) has a restricted tropism for macrophages and CD163 is a key receptor for infection. In this study, the PRRSV strain NCV1 was passaged on MARC-145 cells for 95 passages, and two plaque-clones (C1 and C2) were randomly selected for further analysis. The C1 virus nearly lost the ability to infect porcine alveolar macrophages (PAMs), as well as porcine kidney cells expressing porcine CD163 (PK15-pCD163), while the C2 virus replicates well in these two cell types. Pretreatment of MARC-145 cells with an anti-CD163 antibody nearly blocked C1 virus infection, indicating that the virus still …

Genetic Code Expansion In Pseudomonas Putida Kt2440, Xinyuan He, Tian Gao, Yan Chen, Kun Liu, Jiantao Guo, Wei Niu

Department of Chemical and Biomolecular Engineering: Faculty Publications

Pseudomonas putida KT2440 is an emerging microbial chassis for bio-based chemical production from renewable feedstocks and environmental bioremediation. However, tools for studying, engineering, and modulating protein complexes and biosynthetic enzymes in this organism are largely underdeveloped. Genetic code expansion for the incorporation of unnatural amino acids (unAAs) into proteins can advance such efforts and, furthermore, enable additional controls of biological processes of the strain. In this work, we established the orthogonality of two widely used archaeal tRNA synthetase and tRNA pairs in KT2440. Following the optimization of decoding systems, four unAAs were incorporated into proteins in response to a UAG …

The Emotional Well-Being Of Menstruating Women In South Asia: A Rapid Systematic Review, Payal Patel

Master of Public Health Capstone Presentations

In South Asia, many girls and women experience period poverty which is defined to be a lack of access to or affordability of menstrual hygiene products, washing facilities, and disposal methods. There is also a lack of education and conversation that surrounds menstruation, leading to there being stigma and taboo. With an absence of Wash, Sanitation, and Hygiene (WASH) facilities, women and girls in South Asia are unable to change their pads safely and privately, have access to clean water, and successfully manage their hygiene and health. Apart from the lack of education and WASH facilities, there are also unfair …

Reducing Liver Cancer Risk Through Dietary Change: Positive Results From A Community-Based Educational Initiative In Three Racial/Ethnic Groups, Lin Zhu, Ellen Jaeson Kim, Evelyn González, Marilyn A. Fraser, Steven Zhu, Nathaly Rubio-Torio, Grace X. Ma, Ming-Chin Yeh, Yin Tan

Publications and Research

Dietary behaviors and alcohol consumption have been linked to liver disease and liver cancer. So far, most of the liver cancer awareness campaigns and behavioral interventions have focused on preventive behaviors such as screening and vaccination uptake, while few incorporated dietary aspects of liver cancer prevention. We implemented a community-based education initiative for liver cancer prevention among the African, Asian, and Hispanic populations within the Greater Philadelphia and metropolitan New York City areas. Data from the baseline and the 6-month follow-up surveys were used for the assessment of changes in dietary behaviors and alcohol consumption among participants. In total, we …

"Everything…Fell Apart Once Covid-19 Hit"-Leveraging The Covid-19 Response To Strengthen Public Health Activities Toward Ending The Hiv Epidemic: A Qualitative Study, Samantha A Devlin, Moctezuma Garcia, Kayo Fujimoto, Camden Hallmark, Marlene Mcneese, John Schneider, Moira C Mcnulty

Faculty, Staff and Student Publications

COVID-19 caused widespread disruption of activities for Ending the HIV Epidemic (EHE). In this study we assessed public health perspectives on leveraging the COVID-19 response to advance the goals of EHE. We conducted a qualitative study with 33 public health partners in the Midwestern and Southern United States from October 2020 to February 2022. Participants were asked how the strategies developed for COVID-19 could be applied to the HIV epidemic. Interviews were recorded, transcribed, and examined using rapid qualitative analysis. Four themes emerged: (1) Rebuilding teams and adapting culture for success in EHE activities; (2) Recognizing and modernizing the role …

Internal Vertebral Morphology Of Bony Fishes Matches The Mechanical Demands Of Different Environments, Dana Baxter, Karly E. Cohen, Cassandra M. Donatelli, Eric D. Tytell

Engineering Faculty Articles and Research

Fishes have repeatedly evolved characteristic body shapes depending on how close they live to the substrate. Pelagic fishes live in open water and typically have narrow, streamlined body shapes; benthic and demersal fishes live close to the substrate; and demersal fishes often have deeper bodies. These shape differences are often associated with behavioral differences: pelagic fishes swim nearly constantly, demersal fishes tend to maneuver near the substrate, and benthic fishes often lie in wait on the substrate. We hypothesized that these morphological and behavioral differences would be reflected in the mechanical properties of the body, and specifically in vertebral column …

A Deep Belief Network-Based Clinical Decision System For Patients With Osteosarcoma, Wenle Li, Youzheng Dong, Wencai Liu, Zhiri Tang, Chenyu Sun, Scott Lowe, Shuya Chen, Rachel Bentley, Qin Zhou, Chan Xu, Wanying Li, Bing Wang, Haosheng Wang, Shengtao Dong, Zhaohui Hu, Qiang Liu, Xintian Cai, Xiaowei Feng, Wei Zhao, Chengliang Yin

Student Publications

Osteosarcoma was the most frequent type of malignant primary bone tumor with a poor survival rate mainly occurring in children and adolescents. For precision treatment, an accurate individualized prognosis for Osteosarcoma patients is highly desired. In recent years, many machine learning-based approaches have been used to predict distant metastasis and overall survival based on available individual information. In this study, we compared the performance of the deep belief networks (DBN) algorithm with six other machine learning algorithms, including Random Forest, XGBoost, Decision Tree, Gradient Boosting Machine, Logistic Regression, and Naive Bayes Classifier, to predict lung metastasis for Osteosarcoma patients. Therefore …

Necrotic Lesions And Associated Mites Of The Pinnae Of Free-Living Bats Artibeus Jamaicensis And Sturnira Hondurensis From Mexico, Silvia S. Zalapa, Sergio Guerrero-Vázquez, Cornelio Sánchez-Hernández, Juan B. Morales-Malacara, Gabriela Castaño-Meneses, José L. Navarrete-Heredia, David Ávila-Figueroa, Francisco Javier Padilla-Ramírez

Western North American Naturalist

Lesions of the pinnae of captive bats are common, but there are few reports for free-living bats. In those reports, causal agents of the lesions were attributed to mites, fungus, or a combination of factors, but specific information regarding pinna lesions is generally lacking. This is the first report in Mexico of pinna lesions, associated mites, and histopathological findings for 2 species of free-living bats: the Jamaican fruit-eating bat (Artibeus jamaicensis) and the Honduran yellow-shouldered bat (Sturnira hondurensis).


Reportes de lesiones en las pinas de murciélagos en cautiverio son comunes, pero hay pocos para murciélagos de …

Genome-Transcriptome-Functional Connectivity-Cognition Link Differentiates Schizophrenia From Bipolar Disorder, Jiayu Chen, Zening Fu, Juan R Bustillo, Nora I Perrone-Bizzozero, Dongdong Lin, Jose Canive, Godfrey D Pearlson, Julia M Stephen, Andrew R Mayer, Steven G Potkin, Theo G M Van Erp, Peter Kochunov, L Elliot Hong, Bhim M Adhikari, Ole A Andreassen, Ingrid Agartz, Lars T Westlye, Jing Sui, Yuhui Du, Fabio Macciardi, Faith M Hanlon, Rex E Jung, Jessica A Turner, Jingyu Liu, Vince D Calhoun

Faculty, Staff and Student Publications

BACKGROUND AND HYPOTHESIS: Schizophrenia (SZ) and bipolar disorder (BD) share genetic risk factors, yet patients display differential levels of cognitive impairment. We hypothesized a genome-transcriptome-functional connectivity (frontoparietal)-cognition pathway linked to SZ-versus-BD differences, and conducted a multiscale study to delineate this pathway.

STUDY DESIGNS: Large genome-wide studies provided single nucleotide polymorphisms (SNPs) conferring more risk for SZ than BD, and we identified their regulated genes, namely SZ-biased SNPs and genes. We then (a) computed the polygenic risk score for SZ (PRSSZ) of SZ-biased SNPs and examined its associations with imaging-based frontoparietal functional connectivity (FC) and cognitive performances; (b) examined the spatial …

Fine-Tuned Local Coordination Environment Of Pt Single Atoms On Ceria Controls Catalytic Reactivity, Wei Tan, Shaohua Xie, Duy Le, Weijian Diao, Meiyu Wang, Ke-Bin Low, Dave Austin, Sampyo Hong, Fei Gao, Lin Dong, Lu Ma, Steven N Ehrlich, Talat S Rahman, Fudong Liu

Faculty, Staff and Student Publications

Constructing single atom catalysts with fine-tuned coordination environments can be a promising strategy to achieve satisfactory catalytic performance. Herein, via a simple calcination temperature-control strategy, CeO2 supported Pt single atom catalysts with precisely controlled coordination environments are successfully fabricated. The joint experimental and theoretical analysis reveals that the Pt single atoms on Pt1/CeO2 prepared at 550 °C (Pt/CeO2-550) are mainly located at the edge sites of CeO2 with a Pt-O coordination number of ca. 5, while those prepared at 800 °C (Pt/CeO2-800) are predominantly located at distorted Ce substitution sites on CeO2 terrace with a Pt-O coordination number of ca. …

Scale-Up Of A Rh-Catalyzed Asymmetric Sp3–Sp2 Suzuki–Miyaura-Type Reaction, Laura Cunningham, Mireia Sidera Portela, Stephen P Fletcher

Faculty, Staff and Student Publications

Csp²–Csp² Suzuki–Miyaura couplings (SMCs) are ubiquitous in the synthesis of small molecules, but analogous Csp²–Csp³ bond-forming SMCs are rare, especially asymmetric variants. Recently, we developed a series of Rh-catalyzed couplings between racemic sp³-hybridized allyl chlorides and heteroaryl boronic acids. Here, we demonstrate that these catalytic asymmetric reactions can be scaled-up to give over 100 g of a product. The reaction we chose to test couples a heteroaromatic boronic acid derivative and a racemic bicyclic electrophile to give a product with three contiguous stereogenic centers. The SMC product was obtained as a single …

The Winchcombe Meteorite, A Unique And Pristine Witness From The Outer Solar System, Aj King, L Daly, J Rowe, Et Al

School of Geography, Earth and Environmental Sciences

Direct links between carbonaceous chondrites and their parent bodies in the solar system are rare. The Winchcombe meteorite is the most accurately recorded carbonaceous chondrite fall. Its pre-atmospheric orbit and cosmic-ray exposure age confirm that it arrived on Earth shortly after ejection from a primitive asteroid. Recovered only hours after falling, the composition of the Winchcombe meteorite is largely unmodified by the terrestrial environment. It contains abundant hydrated silicates formed during fluid-rock reactions, and carbon- and nitrogen-bearing organic matter including soluble protein amino acids. The near-pristine hydrogen isotopic composition of the Winchcombe meteorite is comparable to the terrestrial hydrosphere, providing …

Chronic Exposure To Carbon Black Ultrafine Particles Reprograms Macrophage Metabolism And Accelerates Lung Cancer, Cheng-Yen Chang, Ran You, Dominique Armstrong, Ashwini Bandi, Yi-Ting Cheng, Philip M Burkhardt, Luis Becerra-Dominguez, Matthew C Madison, Hui-Ying Tung, Zhimin Zeng, Yifan Wu, Lizhen Song, Patricia E Phillips, Paul Porter, John M Knight, Nagireddy Putluri, Xiaoyi Yuan, Daniela C Marcano, Emily A Mchugh, James M Tour, Andre Catic, Laure Maneix, Bryan M Burt, Hyun-Sung Lee, David B Corry, Farrah Kheradmand

Faculty, Staff and Student Publications

Chronic exposure to airborne carbon black ultrafine (nCB) particles generated from incomplete combustion of organic matter drives IL-17A-dependent emphysema. However, whether and how they alter the immune responses to lung cancer remains unknown. Here, we show that exposure to nCB particles increased PD-L1+ PD-L2+ CD206+ antigen-presenting cells (APCs), exhausted T cells, and Treg cells. Lung macrophages that harbored nCB particles showed selective mitochondrial structure damage and decreased oxidative respiration. Lung macrophages sustained the HIF1α axis that increased glycolysis and lactate production, culminating in an immunosuppressive microenvironment in multiple mouse models of non-small cell lung cancers. Adoptive transfer of lung APCs …

Influence Of Data Sampling Methods On The Representation Of Neural Spiking Activity In Vivo, Meike E Van Der Heijden, Amanda M Brown, Roy V Sillitoe

Duncan NRI Faculty and Staff Publications

No abstract provided.