Digital Commons Network^™

Quantitative Real-Time Pcr Assays For The Detection Of Leptospira, Alice Zhao

Public Health Theses

Leptospirosis is an infectious zoonotic disease caused by bacteria of the genus Leptospira. The genus is comprised of 40 pathogenic species divided among P1 (19) and P2 (21). Leptospirosis incurs a disproportionately large burden of disease in urban slum regions of developing countries that lack adequate sewage disposal, water treatment, and sanitation infrastructure. While P1 species have been identified in cases of human infection, it is unclear if all Leptospira species are capable of infecting humans, especially P2 species. Among P1 species, L. interrogans has been described as the most frequent specie to cause disease in both animals and humans, …

Per- And Polyfluoroalkyl Substances (Pfass) In Household Dust From North China: Occurrence, Contribution, And Human Exposure, Yakun Zhou

Public Health Theses

Measurements and analysis of an emerging contaminant of poly- and perfluoroalkyl substances (PFAS) and adverse health effects associated with PFAS have received increasing attention around the world. In this study, 64 participants’ household dust were collected in Jinan, China during September 2018 and January 2019, conducted as part of the Biomarkers of Air Pollutants Exposure in the Chinese aged 60-69 (China BAPE) study. Concentrations and composition profiles of 7 individual PFASs were determined and estimated daily intakes of PFASs via dust ingestion for children and adults were calculated. By using a dimension reduction method − principal component analysis (PCA) and …

Residential And Race/Ethnicity Disparities In Heat Vulnerability In The United States, Mitchell Manware

Public Health Theses

Adverse health outcomes caused by extreme heat represent the most direct human health threat associated with the warming of the Earth’s climate. Socioeconomic, demographic, health, land cover, and temperature determinants contribute to heat vulnerability; however, nationwide patterns of residential and race/ethnicity disparities in heat vulnerability in the United States are poorly understood. This study aimed to develop a Heat Vulnerability Index (HVI) for the United States; to assess differences in heat vulnerability across geographies that have experienced historical and/or contemporary forms of marginalization; and to quantify HVI by race/ethnicity. Principal components analysis (PCA) was used to calculate census tract level …

Phytoplankton Bloom Stages Estimated From Chlorophyll Pigment Proportions Suggest Delayed Summer Production In Low Sea Ice Years In The Northern Bering Sea, Clare B. Gaffey, Karen E. Frey, Lee W. Cooper, Jacqueline M. Grebmeier

Geography

Decreased sea ice cover in the northern Bering Sea has altered annual phytoplankton phenology owing to an expansion of open water duration and its impact on ocean stratification. Limitations of satellite remote sensing such as the inability to detect bloom activity throughout the water column, under ice, and in cloudy conditions dictate the need for shipboard based measurements to provide more information on bloom dynamics. In this study, we adapted remote sensing land cover classification techniques to provide a new means to determine bloom stage from shipboard samples. Specifically, we used multiyear satellite time series of chlorophyll a to determine …

Analysis Of Sex-Specific Prostanoid Production Using A Mouse Model Of Selective Cyclooxygenase-2 Inhibition, Rita K. Upmacis, Wendy L. Becker, Donna M. Rattendi, Raven S. Bell, Kelsey D. Jordan, Shayan Saniei, Elena Mejia

Faculty Papers and Publications

Background: Prostanoids are a family of lipid mediators formed from arachidonic acid by cyclooxygenase enzymes and serve as biomarkers of vascular function. Prostanoid production may be different in males and females indicating that different therapeutic approaches may be required during disease.

Objecti ves: We examined sex-dependent differences in COX-related metabolites in genetically modified mice that produce a cyclooxygenase- 2 (COX2) enzyme containing a tyrosine 385 to phenylalanine (Y385F) mutation. This mutation renders the COX2 enzyme unable to form a key intermediate radical required for complete arachidonic acid metabolism and provides a model of selective COX2 inhibition.

Design and …

Where There's A Will There's A Way: Examining The Possible Impacts Of The Covid-19 Pandemic On Incidents Of Mass Violence In The Usa, Gordon A. Crews, Garrison A. Crews, Samantha Leigh Crews

Criminal Justice Faculty Publications

“Where there’s a will there’s a way” is a proverb that simply means if someone is determined to do something, he or she will find a way to accomplish it regardless of obstacles. Unfortunately, this is very true for those who wish to commit acts of violence wish to commit acts of violence. The purpose of this chapter is to examine the possible impacts of the COVID-19 pandemic on incidents of mass and multiple victim violence in the US. More specifically, what impact did efforts such as stay-athome/shelter-in-place orders, telecommuting options for workers, school closures, cancellation of large public events, …

World Of Water: Betsy Damon’S Ties To Ecofeminism, Colleen Sullivan

Dissertations and Theses

This thesis establishes a critical examination of the evolution of Betsy Damon’s artistic practice as overtime she engages with ecofeminist thought. As a whole, this work extends contemporary scholarship on ecofeminist engaged art to include Damon’s artistic production while amplifying social and critical ecofeminism as necessary ideologies to explore when analyzing art through an ecofeminist lens. Beginning with her first environmentally focused work in the United States the organization of the following chapters reveals Damon’s deepened understanding and exploration of ecofeminist principles and their application to her artistic practice. It goes on to further explore Damon’s pursuit of environmentally sustainable …

Poly(Β-Gal-Thr): A New Scalable Synthetic Mucin, Manuel A. Lema

Dissertations and Theses

A method for the preparation of glycosylated polypeptides via the nucleophilic ring-opening polymerization of a glycosylated N-carboxyanhydride (NCA) monomer is reported. The synthesis of 2,3,4,6-tetraacetyl-β-galactose-threonine N-carboxyanhydride (β-AcO-Gal-Thr-NCA) monomer in 5 steps with an 8 % overall yield is described, and the single-crystal X-ray structure is provided. The effect of a series of Ni⁰-based organometallic initiators, nucleophilic amine initiators, co-catalysts, and solvents on the polymerization were explored. The kinetics of the three most promising conditions were studied in greater detail. The conditions that provided the highest yield, low polydispersity (Ð), and …

The Role Of Rna Helicase Rhau In Immunoglobulin Class Switch Recombination, Sabine Jean Guillaume

Dissertations and Theses

B cells alter the expression of immunoglobulin isotypes through a process known as class switch recombination (CSR). In these cells, activation induced cytidine deaminase (AID) binds Gquadruplex (G4) switch transcripts, which serve as guide RNAs to target AID to the immunoglobulin heavy chain switch (S) regions in the DNA for CSR. Sequence alignment revealed homology between the AID G4 binding domain and the RNA helicase associated with AU-rich element (RHAU) specific motif (RSM), which allows RHAU binding to G4 RNAs and subsequent unwinding of G4 RNA into single-stranded transcripts. We hypothesize that RHAU functions in CSR by binding G4 S …

African American English As A Predictor Of Ethnic And Ethnolinguistic Identity In Adolescence, Giahna L. Glasco

Dissertations and Theses

This study’s purposes were to provide support for the Social identity theory of African American English (Vietze & Glasco, 2022) and the meanings African American English (AAE) speakers assign to their dialect. The study was primarily based on Tajfel’s (1979) social identity theory that proposes individuals derive a sense of self from group membership. The qualitative analyses examined ethnic and language group memberships. Ethnic identity development (Phinney, 1992), and ethnolinguistic identity theories (Giles and Johnson, 1987) guided narrative and content analyses of Kiese Laymon’s memoir, Heavy: An American Memoir (Laymon, 2018). The sample included 21 African American English conversations …

The Nexus Of Climate Change, Biodiversity, And Food Security: A Brazil Case Study, Andrew M. Berger

Dissertations and Theses

What is referred to as climate change today is the rapid warming of the climate, largely from human actions, and the effects that come with that warming. One study published by the United States Department of Agriculture (USDA) in 2021 argues that, “human-induced emissions of greenhouse gases have caused increases in global average temperatures, changes in precipitation timing and intensity, rising sea levels, and many other changes.” A Food and Agriculture Organization (FAO) study found that when looking at the number of countries exposed to climate extremes in five year periods from 2000 to 2020, the number of countries “exposed …

Youth Musicians’ Executive Functioning And Its Impact On Emotional And Behavioral Health, Michael A. Tate

Dissertations and Theses

A growing body of neuroscience literature shows that music promotes brain development, as learning a music instrument involves multiple brain regions and neurocognitive systems. In partnership with a non-profit organization with a mission to strengthen New York City communities through music education programs, this study aimed to evaluate the effects of music training on children’s executive functioning (EF), as well as emotional and behavioral outcomes. We hypothesized that (i) children’s EF would develop more rapidly with exposure to the program; (ii) the intensity of practice would be associated with rate of growth of children’s EF, emotion regulation and behavior; (iii) …

Examining The Effect Of Object Relations And Defense Mechanisms On Interpersonal Relations In Adults With Adhd Symptoms, Cherise White

Dissertations and Theses

Impaired interpersonal functioning, often persistent from childhood through adulthood, is common in ADHD. Symptoms of ADHD such as restlessness and impulsivity may result in behaviors such as being overly talkative, interrupting or intruding on others already engaged in activities, while inattentive symptoms may result in a person being perceived as aloof, indifferent, and/or uncaring (APA, 2013; Friedman et al., 2003). As compared to adults without a history of elevated ADHD symptoms, more impaired interpersonal functioning has been found among young adults with ADHD, and this increased impairment in adults with ADHD is often a primary reason they pursue therapy (Horowitz …

Early Risk Factors For School-Age Adhd And Irritability: The Roles Of Prenatal Risk, Intrusive Parenting Style During Preschool And Caregiver-Child Attachment Quality., Ashley M. Rainford

Dissertations and Theses

ADHD is a highly impairing neurodevelopmental disorder and the family context provides a critical early environment where children’s risk for the disorder may be heightened or reduced. A parent’s style, that is their approach to interacting and guiding the child may provide children with warmth and security, or elicit fear, distrust and disappointment, both of which in turn impact behavior. However, the parent-child relationship is not unidirectional; it is dynamic. Children with high ADHD-like behaviors have greater difficulty relating to and interacting with their caregivers, while caregivers become increasingly stressed and show greater hostility and less warmth in their parenting. …

Loneliness, Interpersonal Sensitivity And The Mechanisms Through Which The Dimensions Of Trait Emotional Intelligence May Protect Against Clinical Depression, Eva H. Leighton

Dissertations and Theses

Reducing the prevalence of loneliness and depression are important public health objectives. This dissertation aims to contribute to these objectives by improving our understanding of the relationship between loneliness and depression. Specifically, we assessed three additional constructs known to be strongly associated with loneliness and depression –-perceived social support, emotional intelligence, and interpersonal sensitivity –- with the aim of showing how these three constructs influence the relationship between loneliness and depression. Previous research that jointly examines all five constructs has not been identified by the author in an extensive search of prior literature.

Specifically, this dissertation tested the following hypotheses: …

Identification Of Adhd And Comorbid Disorders In Children: The Potential Role Of Minority Group Membership, Rachel H. Tayler

Dissertations and Theses

Identification of ADHD and Comorbid Disorders in Children: The potential role of minority group membership

by

Rachel Tayler, MSc, MA

Advisor: Sarah O’Neill, PhD

Attention-Deficit/Hyperactivity Disorder (ADHD) affects six million US children. Females, Latinx, and possibly Black children have lower rates of diagnosis than their Male and White non-Latinx peers. ADHD is behaviorally defined, and as such, clinicians' perceptions of symptoms and determination of diagnoses may be influenced by demographic factors such as race, ethnicity and sex.

This vignette study examined whether clinicians' implicit ethnic, racial, and sex biases affect diagnosis of ADHD and comorbid conditions. Psychiatry trainees and pediatricians …

Being Black & Blue: Sex As A Moderator Between Adverse Childhood Experiences And Depressive Symptoms Among Black Emerging Adults, Wynta C. Alexander

Dissertations and Theses

Adverse Childhood Experiences (ACEs) have been linked to adult mental health consequences (e.g., depressive symptoms). Black people are disproportionately affected by ACEs, and factors related to ethnic subgroups and/or sex may produce differential depressive outcomes. The current study examined the moderating role of sex in the association between adverse childhood experiences and depression symptoms using a life course of health approach among a sample of Black emerging adults. Participants (n = 159) of the current study were Black (e.g., African – American) and Black Caribbean (e.g., Jamaican) undergraduate students (18 – 59 years old; 72.3% female) attending a large, public …

The Study Of 3d Micro-Fluid Printing In Aqueous Two-Phase System, Mian Huang

Dissertations and Theses

Aqueous two-phase system (ATPS) is a technology that allows phase separation in an aqueous environment. This technology can be used for the separation, extraction and purification of a variety of biomolecules and thus gained great attention in industry and academia. This thesis is a combination of ATPS, 3D printing, and microfluidics technologies and realizes the printing of biocompatible aqueous structures in another aqueous matrix. The objectives of this thesis include 1) customizing a regular thermal extrusion 3D printer for printing 3D aqueous structures, 2) printing 3D aqueous structure in an aqueous matrix, and 3) studying the stability of the printed …

Novel Mechanisms Of Dc And Kilohertz Electrical Stimulation, Zeinab Esmaeilpour

Dissertations and Theses

Transcranial electrical stimulation is a promising technique where a weak electrical current is applied to the scalp with the goal of modulating brain activity. Understanding the cellular mechanism of direct current (DC) and kilohertz (kHz) electrical stimulation is of broad interest in neuromodulation. More specifically, there is a large mismatch between enthusiasm for clinical applications of the method and understanding of DC and kHz novel mechanisms of action. This dissertation is centered around two main fundamental aims: 1) systematic study of the acute and long-term effects of kilohertz electrical stimulation and amplitude-modulated waveform with kHz carrier frequency using a well-established …

Impact Of Percutaneous Transluminal Intervention On Vascular Hypoxia And The Role Of Micro-Calcifications On Atherosclerotic Plaque Rupture, Andrea Corti

Dissertations and Theses

Atherosclerotic disease is initiated by cholesterol build-up beneath the endothelium, which evolves into a fibroatheroma, a lipid-rich plaque covered by a fibrous cap. Many of these plaques are considered as vulnerable, as they grow to occlude the luminal section of the artery (chronically stenotic) or become mechanically unstable with a higher chance of rupturing (rupture-prone). On one hand, chronically stenotic vulnerable plaques are symptomatic lesions that are often treated with Percutaneous Transluminal Intervention (PTI). Unfortunately, approximately 10% of PTI procedures are followed by severe Neointima Hyperplasia (NH), which causes a new occlusion and failure of the implant. A significant precursor …

Design And Control Of Quasi-Direct Drive Actuation For Lightweight And Versatile Wearable Robots, Shuangyue Yu

Dissertations and Theses

Wearable robots have shown great potential for augmenting the physical capabilities of humans in lab settings. However, wearable robots for augmenting the physical capabilities of humans under community-based conditions are the new frontier of robotics. Furthermore, the design and control are still considered to be grand challenges for providing physical augmentation for humans. In terms of design, the state-of-the-art exoskeletons are typically rigid, bulky, and limited to lab settings. In terms of control, most of the rhythmic controllers are not versatile and are focused only on steady-state walking assistance.

The motivation behind my research is to improve both the design …

The Use Of Multiple Saliency Techniques As An Explanation Interface In General Image Recognition, Robert N. Moss Mr

Dissertations and Theses

AI diagnostic machines that preform beyond that of human intelligence have yet to be implemented into society at large in substantiative ways. Examples in research of AI that can diagnose cancer, narcolepsy, renal diseases, and cardiac damage abound, yet these machines have to be implemented into clinical settings. Although predictively powerful, these diagnostic machines are powered by Deep Convolutional Neural Networks that operate as virtual black- boxes and the medical community is unwilling to accept predictions that lack explanation. To this end Explainable Artificial Intelligence is developing a host of methods that seek to pry open the inner workings DNNs …

Fundamentals Of Microgel Flooding And Nanoparticles-Stabilized Foams In Enhanced Oil Recovery, Shuaijun Li

Dissertations and Theses

For centuries oil has remained a critical energy source for human civilization. After years of extraction, many oil fields have reached or are reaching a decline stage of production, even though up to a half of the total crude oil reserves in these fields has not been recovered yet. One reason is due to the structural heterogeneity of the oil reservoirs—reservoirs may consist of regions of higher permeability with larger pore size and regions of lower permeability with smaller pore size. Displacing fluids tend to flow through large permeability zones only without reaching the oil trapped in low permeability region; …

The Impact Of Covid-19 On Building Energy Consumption In New York City, Martha A. Olaleye

Dissertations and Theses

Since February 2020, the spread of COVID-19 affected the world economy, with the population of people contacting the virus in New York City at that time being at the highest in the United States of America. Thus, the need for remote/online learning was adopted for the safety of faculty, staffs, and students of New York Educational institution like CCNY. In the study, I focused on energy consumption as regards to COVID and POST-COVID periods in New York City (NYC), since most employees are working from home and schools are online which implies that most commercial buildings are vacant. Also due …

Osseointegration Of A Cementless Total Knee Arthroplasty In A Murine Model Of Glucocorticoid Induced Osteoporosis, Elexis C. Baral

Dissertations and Theses

Glucocorticoid-Induced Osteoporosis (GIOP) is the second largest cause of osteoporosis worldwide. Glucocorticoid-Induced osteoporosis is rapidly, driven principally by deficient osteoblast activity (i.e., decreased bone formation) rather than increased osteoclastic activity. Glucocorticoid-type steroids (GC) are used long-term typically for inflammatory diseases such as rheumatoid arthritis, lupus, multiple sclerosis, and other autoimmune disorders. Inflammatory arthritis often leads to joint replacement at relatively young ages. However, patients who are on GC treatment appear to have poorer outcomes for total joint arthroplasty compared to healthy patients. This is thought to be due to the anti-anabolic effects of GCs and impaired bone healing and osseous …

Nonlinear Light - Matter Interactions Of Ultrafast High Intensity Laser Pulses, Henry Meyer

Dissertations and Theses

This thesis focuses on the key nonlinear optical effects that arise from the interactions of intense ultrafast laser pulses with various states of matter. These interactions involve electronic and molecular states and yield new information on the underlying fundamental processes that govern the molecular world. Modern day lasers offer ultrashort pulses, high intensities, and complex polarizations and wavefronts. These extreme conditions have profound effect on the optical properties and behaviors of electronic and molecular states within a material. The changes in these mechanisms effect generation of nonlinear optics, such supercontinuum (SC), stimulated Raman (SRS), self-focusing and filamentation, conical emission (CE), …

Computational Model Of Electroconvulsive Therapy Considering Electric Field Dependent Skin Conductivity, Gozde Unal

Dissertations and Theses

Improvements in electroconvulsive therapy (ECT) outcomes have followed refinement in device electrical output and electrode montage. The physical properties of the ECT stimulus, together with those of the patient’s head, determine the impedances measured by the device and govern current delivery to the brain and ECT outcomes. However, the precise relations among physical properties of the stimulus, patient head anatomy, and patient-specific impedance to the passage of current are long-standing questions in ECT research and practice. In this thesis, we develop a computational framework based on diverse clinical data sets. We developed anatomical MRI-derived models of transcranial electrical stimulation (tES) …

Droplets In An Electric Field: Surface Rheology, Coalescence And Rebound, Yu Han

Dissertations and Theses

Electrocoalescence is the process in which pairs of conducting droplets suspended in a continuous dielectric (nonconducting) liquid phase are drawn together and merge upon the application of an electric field. The electric field polarizes each of the droplets in the field direction. The polarization causes the drops to deform and drives a dipolar attraction which forces them to approach each other and coalesce. Many technologies use electric fields to manipulate fluid dispersions. Electrocoalescence is an essential unit operation for separating water droplets in a crude oil. This water in oil emulsion is stabilized by surfactants, such as asphaltenes, resins and …

Development Of Cellulose-Based, Semi-Interpenetrating Network Hydrogels As Tissue-Adhesive, Thermoresponsive, Injectable Implants, Jesse Martin

Dissertations and Theses

Abstract Development of Cellulose-Based, Semi-Interpenetrating Network Hydrogels as Tissue-Adhesive, Thermoresponsive, Injectable Implants

Hydrogels are three-dimensional polymer networks with high water content and tunable mechanical properties, which have been widely investigated as replacements for soft tissues, such as the intervertebral disc (IVD). Various derivatives of the plant polysaccharide, cellulose, have been explored for use as injectable hydrogel implants. Methylcellulose (MC), which exhibits thermogelation at temperatures above 32°C, and relatively hydrophilic carboxymethyl-cellulose (CMC), are versatile cellulosic polymers that have shown promise as base materials for such applications. In prior work, functionalization with methacrylate groups allowed for the formation of stable, covalently crosslinked …

Low-Intensity Ultrasonic Neuromodulation Of The Rat Hippocampus, Duc Nguyen

Dissertations and Theses

Techniques to non-invasively modulate brain activity are important for mapping human brain circuits, and also for the treatment of a host of neurological and psychiatric disorders marked by aberrant brain activity. Though a wide range of techniques for non-invasive neuromodulation have been proposed, the conventional approaches suffer from significant limitations. Most notably, focal stimulation of deep brain regions is presently only possible with invasive optogenetic and chemogenetic approaches that require craniotomies and genetic access to the brain.

Transcranial focused ultrasound stimulation (tFUS) possesses many of the characteristics desirable from a neuromodulation approach: non-invasiveness, a spatial resolution in the order of …