Digital Commons Network^™

Airborne Fungal Spore Review, New Advances And Automatisation, Moisés Martínez-Bracero, Emma Markey, Jerry Hourihane Clancy, Eoin Mcgillicuddy, Gavin Sewell, David J. O'Connor

Articles

Fungal spores make up a significant portion of Primary Biological Aerosol Particles (PBAPs) with large quantities of such particles noted in the air. Fungal particles are of interest because of their potential to affect the health of both plants and humans. They are omnipresent in the atmosphere year-round, with concentrations varying due to meteorological parameters and location. Equally, differences between indoor and outdoor fungal spore concentrations and dispersal play an important role in occupational health. This review attempts to summarise the different spore sampling methods, identify the most important spore types in terms of negative effects on crops and the …

Exosomal-Long Non-Coding Rnas Journey In Colorectal Cancer: Evil And Goodness Faces Of Key Players, Nehal I. Rizk, Ahmed I. Abulsoud, Mohamed M. Kamal, Dina H. Kassem, Nadia M. Hamdy

Pharmacy

Exosomes are nano-vesicles (NVs) secreted by cells and take part in cell-cell communications. Lately, these exosomes were proved to have dual faces in cancer. Actually, they can contribute to carcinogenesis through epithelial-mesenchymal transition (EMT), angiogenesis, metastasis and tumor microenvironment (TME) of various cancers, including colorectal cancer (CRC). On the other hand, they can be potential targets for cancer treatment. CRC is one of the most frequent tumors worldwide, with incidence rates rising in the recent decades. In its early stage, CRC is asymptomatic with poor treatment outcomes. Therefore, finding a non-invasive, early diagnostic biomarker tool and/or suitable defender to combat …

Sources And Therapeutic Strategies Of Mesenchymal Stem Cells In Regenerative Medicine, Mohamed M. Kamal, Dina H. Kassem

Pharmacy

During the past decade, mesenchymal stem cells (MSCs) have made their mark as a potential weapon in regenerative medicine. Since their first isolation by Friedenstein in the late 1970s of the last century, MSCs have opened new avenues in the field of regenerative medicine. The main fascination about MSCs lies in their ease of isolation and large ex vivo expansion capacity, as well as demonstrated multipotency and immunomodulatory activities. Basically, several reports have proved that MSCs isolated from different sources possess different characteristics and potentials. In addition, the mechanisms by which these cells can help regenerate tissues and treat several …

We Can Still Feed Ourselves: Food Sovereignty, Aid, Sickness, And Health In Eastern Kentucky, Annie Koempel

Theses and Dissertations--Anthropology

Over forty percent of eastern Kentucky residents are classified as obese. From a biomedical perspective, obesity is linked to a range of chronic diseases, including heart disease, diabetes, and high blood pressure and is caused by particular lifestyle behaviors that lead to an increase in calorie consumption and decrease in calorie expenditure. However, these links – individual behavior leads to obesity which leads to chronic disease - do not take into account a wide range of personal, social, environmental, political, and economic conditions. In addition to the assumptions of what it means to become and be obese, Kentucky is regularly …

Public Citizen's Advocacy Campaign Opposing Fda Approval Of Aducanumab For Alzheimer's Disease: The Fight Against Regulatory Capture, Michael A. Carome

Health Matrix: The Journal of Law-Medicine

No abstract provided.

Diversity's Pandemic Distractions, Jonathan Kahn

Health Matrix: The Journal of Law-Medicine

No abstract provided.

Filling In The Gaps: Inaccurate Medical Records In Adoption, Leah Rothfeld

Health Matrix: The Journal of Law-Medicine

No abstract provided.

Elevated Blood Lead Levels As Eligibility Criteria For Early Intervention Programs, Meghan Sink

Health Matrix: The Journal of Law-Medicine

No abstract provided.

Abolishing The Evidence-Based Paradigm, Erin Collins

Law Faculty Publications

The belief that policies and procedures should be data-driven and “evidence-based” has become criminal law’s leading paradigm for reform. This evidence-based paradigm, which promotes quantitative data collection and empirical analysis to shape and assess reforms, has been widely embraced for its potential to cure the emotional and political pathologies that led to mass incarceration. It has influenced reforms across the criminal procedure spectrum, from predictive policing through actuarial sentencing. The paradigm’s appeal is clear: it promises an objective approach that lets data – not politics – lead the way and purports to have no agenda beyond identifying effective, efficient reforms. …

Protect And Serve, Marissa Jackson Sow

Law Faculty Publications

There exists a substantial body of literature on racism and brutality in policing, police reform and abolition, the militarization of the police, and the relationship of the police to the State and its citizenry. Many theories abound with respect to the relationship between the police and Black people in the United States, and most of these theories rest upon the basic assumption—undergirded by constitutional, civil rights, and human rights law—that Black people in the United States are entitled to due process and equal protection when they are in contact with the police or other law enforcement officers.

This Article uses …

Assessing The Potential Of The Unexploited Atlantic Purple Sea Urchin, Arbacia Punctulata, For The Edible Market, Coleen Suckling, Max D. Zavell, Anna L. Byczynski, Brian T. Takeda

Fisheries, Animal and Veterinary Sciences Faculty Publications

The global demand for sea urchin as seafood is currently unmet. Despite exploitation of > 40 species across the world, there is a need to identify other candidate species, especially in regions where diversification in production is sought where species are considered native. The Eastern US presents an opportunity to determine the marketability of the currently unexploited Arbacia punctulata which is naturally distributed from Massachusetts and southwards into the Gulf of Mexico. To determine whether A. punctulata had market potential, it was fed one of the following diets to determine whether the gonad tissue (uni) could be manipulated to increase gonad …

Evaluating Beluga (Delphinapterus Leucas) Blow Samples As A Potential Diagnostic For Immune Function Gene Expression Within The Respiratory System, Justin Thomas Richard, Krystle Schultz, Caroline E.C. Goertz, Roderick C. Hobbs, Tracy A. Romano, Becky L. Sartini

Fisheries, Animal and Veterinary Sciences Faculty Publications

Evaluating respiratory health is important in the management of cetaceans, which are vulnerable to respiratory diseases. Quantifying the expression of genes related to immune function within the respiratory tract could be a valuable tool for directly assessing respiratory health. Blow (exhale) samples allow DNA analysis, and we hypothesized that RNA could also be isolated from blow samples for gene expression studies of immune function. We evaluated the potential to extract RNA from beluga blow samples and tested whether transcripts associated with immune function could be detected with endpoint polymerase chain reaction. A total of 54 blow samples were collected from …

Why Not Both Nature And Nurture: Using Behavioral Genetic Markers As Sentencing Factors, Seely Kaufmann

Law Student Publications

"On the evening of July 1, 2013, Amos Wells was upset that his pregnant girlfriend, Chanice Reed, would not answer his calls. He then drove to where she, her mother Annette, and ten-year-old brother Eddie, lived. After arguing with Chanice and yelling at the top of his voice in a “bone-chilling scream,” Wells retrieved a handgun from his Chevrolet Tahoe parked in front of the house, and shot Chanice in the front yard as she screamed, “No, no, no.” Her mother then tried to bat the gun away before he shot her too. Further shots were heard before Wells finally …

Biology News 2022, University Of Northern Iowa. Department Of Biology.

Biology News

Contents:

Letter from the Department Head ---- 2
Preparing Science Teachers ---- 2
Learning Biology at UNI ---- 3
In Case You Missed it ---- 4
Ch-ch-ch Changes ---- 4
Support the Programs that Mean the Most to You ---- 5
Connect with Us ---- 5

The Wright Message, 2021-2022, University Of Northern Iowa. Department Of Mathematics.

The Wright Message

Contents

From the Dean --- 1
Around Wright Hall --- 3
In Memoriam: Diane Lee Baum --- 4
Faculty Spotlight --- 4
Retiring Faculty --- 5
Statistical Consulting Center staff changes --- 7
Alumni Spotlight --- 8
News from the CTLM --- 10
Student Spotlights --- 11
Donor Spotlight --- 18
First Woman to Win International Meshing Award --- 19
Contribution Recognition --- 20
Department Funds --- 22
Contribution Forms --- 23

Csbs Statements, V24, 2022, University Of Northern Iowa. College Of Social And Behavioral Sciences.

CSBS Statements

Contents:

Experiencing Dementia --- 5
Underground Iowans --- 8
Tripp of a Lifetime --- 10
Suitcase of Knowledge --- 12
A Beloved Professor's Lasting Gift --- 14
College News --- 16
Alumni Spotlight --- 24
Donor Spotlight --- 30
Annual Giving --- 32
Class Notes --- 34

Examining Sex And Race Difference In Obesity Risk Factors In Older Americans Using Genetic And Lifestyle Data In Regards, Hairui Yu

All ETDs from UAB

Obesity is a prevalent chronic condition determined by social, psychological, behavioral, and biological factors. The prevalence of obesity remains a major public health issue and has continued to rise in the United States and around the world. People who are obese face a higher risk of cardiovascular and metabolic diseases. The fat mass and obesityassociated gene (FTO) is one of the most commonly identified genes in obesity-related research. This three-paper dissertation is aimed at improving understanding of sex and race differences in obesity risk factors in older Americans from genetic (FTO SNPs) and lifestyle (diet and physical activity) perspectives, using …

Targeting The Frataxin Transcriptional Defect As A Therapeutic Approach For Friedreich's Ataxia, Anna Maria Schreiber

All ETDs from UAB

Friedreich’s ataxia (FRDA) is the most common inherited ataxia worldwide. This autosomal recessive neurodegenerative disorder manifests in the central and peripheral nervous system but also affects the cardiovascular and endocrine systems. No effective treatment is available. FRDA is caused by expansion of GAA repeat tracts in intron 1 of the frataxin (FXN) gene on both alleles. An inverse correlation between FXN levels and GAA repeat length exists. Frataxin is a mitochondrial protein participating in iron-sulfur (Fe-S) cluster formation. Frataxin deficiency results in reduced activity of Fe-S-containing enzymes involved in critical biological processes, such as cellular respiration and DNA repair. Expansion …

The Role Of The Bone Marrow Microenvironment In Flt3-Itd Acute Myeloid Leukemia Stem Cell Resistance To Flt3 Inhibition, Nicholas R. Anderson

All ETDs from UAB

Acute myeloid leukemia (AML) is an aggressive, complex hematological malignancy. AML cases with constitutively-activating internal tandem duplications in the Flt3 receptor (Flt3-ITD) represent a distinct subtype of disease with poor prognosis, but unique opportunities for targeted therapy. Flt3-specific tyrosine kinase inhibitors (TKI) have entered clinical practice due to their ability to induce remissions in a large proportion of Flt3-mutant AML patients, but their long-term efficacy remains limited due to the persistence of leukemia stem cells (LSC) in the bone marrow (BM). Herein, we outline the importance of the bone marrow microenvironment (BMM) in harboring LSC through AML development and drug …

A Hybrid Data And Hypothesis-Driven Model For Software Development In Support Of The Machine-Learning Paradigm, Anthony D. Bowman

All ETDs from UAB

istorically, research has often been conducted in a hypothesis-driven manner with software development methodologies created to support those efforts. However, in recent years data-driven approaches to research have seen a dramatic rise in prominence. While software development methodologies such as agile development, extreme programming, and the waterfall model have allowed developers to tackle increasingly complex problems, they were not designed to efficiently support data-driven approaches such as the machine learning paradigm. To address the need to support the different programmatic requirements of both classical, hypothesis-driven as well as data-driven development, novel development strategies are warranted. In this research, we adapted …

Defining Genetic Underpinnings Of Cellular Diversity And Vulnerability In The Context Of Parkinson's Disease, Stephanie M. Boas

All ETDs from UAB

of ALL survivors are at risk for reduced functional outcomes, and these outcomes may be more strongly related to executive functioning than neighborhood-specific variables or IEP support. Long-term goals include translating findings into practice to remediate adaptive or academic difficulties in ALL survivors.

Urban Research University

Evidence Inventory

Urban Research University

University Profile: 2021, Kean University

Evidence Inventory

No abstract provided.

Student-Organized Cultural Events, Kean University

Evidence Inventory

No abstract provided.

Preventing Unintentional Childhood Injuries In Rural Uganda: Caregiver Perceptions And Promotion Of Personal Safety Skills Through Classroom-Based Instruction, Marissa H. Swanson

All ETDs from UAB

Objective: Unintentional childhood injuries present a substantial public health burden in low- and middle-income countries (LMIC) including Uganda. Interventions to reduce this risk should be responsive to children’s unique developmental, environmental, and sociocultural context. This project had three primary objectives: 1) Analyzing caregiver reports of child injury events in rural Uganda to identify perceived causal and preventative factors; 2) Identifying Ugandan first and sixth graders’ developmental safety needs by comparing hazard recognition and past-year injuries among these students; and 3) Evaluating the impact of the Careful Cubs intervention on Ugandan first graders’ personal safety knowledge, skills, and beliefs. Methods: 1) …

Understanding The Protumorigenic Functions Of St6gal1 In Glioblastoma Stemness And Metabolism, Sajina Gc

All ETDs from UAB

Glioblastoma (GBM) is a rare but deadly cancer with median survival of just 15 months despite of aggressive treatment. Advancement in novel treatment modalities is hindered by its heterogeneous nature, which includes subsets of neural stem cell-like brain tumor initiating cells (BTICs) that are highly tumorigenic and therapy-resistant. bgalactoside a-2,6-sialyltransferase 1 (ST6Gal1) is elevated in most tumors including in normal and neoplastic stem cells. ST6Gal1 imparts oncogenic phenotypes such as invasion, apoptosis evasion, therapy resistance, TIC maintenance among others via sialylation of critical receptors like, Fas, TNFR1, EGFR and more. Yet ST6Gal1 led regulation of BTIC specific cell surface proteins …

The Evolutionary Ecology Of The Antarctic Red Macroalga Plocamium Sp. In Relation To Its Defensive Secondary Metabolite Diversity, Sabrina Heiser

All ETDs from UAB

Organisms produce chemical defenses to gain a competitive advantage, and to protect themselves from pathogens and predators. There is high inter- and, sometimes, intraspecific diversity in the types and quantities of defensive secondary metabolites. Yet, we do not know much about the mechanisms driving the diversity and its distribution. Macroalgae are important members of ecosystems since they provide living space and are primary producers. To prevent predation, macroalgae make structural or chemical defenses. Chemical defenses in the Antarctic red macroalga Plocamium sp. have extensively been studied. It is widespread along the western Antarctic Peninsula and abundant at sites where it …

Characterization Of Exercise-Associated Skeletal Muscle Secreted Factors Through Aging, Dalton Chase Patterson

All ETDs from UAB

Exercise is a powerful behavioral intervention against Central Nervous System (CNS) aging1–3 and plays an essential role in maintaining healthy neurocognitive function and immune metabolism in the aging brain3. We have developed a new transgenic mouse model that moderately over-expresses transcription factor master regulator of proteostasis, Transcription Factor E-B (TFEB), in skeletal muscle (cTFEB;HSACre mice). Despite living sedentary lifestyles, our model of enhanced skeletal muscle proteostasis shows significantly ameliorated proteotoxicity, increased BDNF levels and neurogenesis while improving neurocognitive function and decreasing neuroinflammation in the aging CNS4,5. These neuroprotective effects are markedly reminiscent of those observed in the aging CNS post-exercise6,7, …

Labor Union Membership Tenure And Midlife Health: A Gendered Perspective, Clifford Ross

All ETDs from UAB

The benefits of labor unions have not gone unstudied. Individuals in labor unions have better access to lower cost/more substantial health insurance plans, higher quality pension plans, and better wages leading to increased lifetime earnings. Even though many of these benefits create important pathways that could lead to better health, unions have been paid little attention in health literature. Additionally, in the modern workplace Mothers are offered lower starting salaries, are perceived as less competent, and face a penalty regarding hiring, promotion, and workplace educational opportunities. Compared to men, women with children see an income gap 20 cents wider than …

The Role Ofbiomechanics In Vascular Endothelial Growth Factor Receptor-2 Signaling, Bronte Miller

All ETDs from UAB

Angiogenesis, or the growth of new vasculature from existing blood vessels, is widely considered a primary hallmark of cancer progression. When a tumor is small, diffusion is sufficient to receive essential nutrients; however, as the tumor grows a vascular supply is needed to deliver oxygen and nutrients into the increasing mass. Several anti-angiogenic cancer therapies target VEGF and its receptor VEGFR-2, which are major promoters of blood vessel development. Unfortunately, many of these cancer treatments fail to completely stop angiogenesis in the tumor microenvironment (TME). Since these therapies focus on the biochemical activation of VEGFR-2 via VEGF ligand binding, we …