Digital Commons Network^™

Exploring The Role Of Divalent Mg2+ Dependent Methyl Transfer In Mycobacterium Abscessus, Giavana Prucha

Renée Crown University Honors Thesis Projects - All

No abstract provided.

Clinical And Molecular Characterization Of The Effects Of Pantothenate Kinase 2 Mutations In A Dominican Population Isolate, Ifeyinwa Ojukwu

Renée Crown University Honors Thesis Projects - All

No abstract provided.

The Effect Of A 3-Month Lacto-Ovo Vegetarian Diet Intervention On Diet Quality And Dietary Mindfulness, Olivia Templeton

Renée Crown University Honors Thesis Projects - All

No abstract provided.

The Effect Of A 3-Month Lacto-Ovo Vegetarian Diet Intervention On Inflammation, Samantha Jezak

Renée Crown University Honors Thesis Projects - All

No abstract provided.

Investigating Reln R2457c Mutation In Comparison Other Reelin Variants And Its Relationship To Autism Spectrum Disorder Risk Factors, Seth Martin Jr.

Renée Crown University Honors Thesis Projects - All

No abstract provided.

Relations Among Tree Demography, Microclimate, And Soil Conditions At Alpine Treelines In The Adirondack Mountains, Northeastern Unitd States, Samuel Mcclintic

Renée Crown University Honors Thesis Projects - All

No abstract provided.

Reducing Future Healthcare Provider Implicit Bias Through Mindfulness-Based Practices In Pre-Health Schooling: A Qualitative Systematic Review, Zoe Landskroner

Renée Crown University Honors Thesis Projects - All

No abstract provided.

Predictive Cell Tracking Using Machine Learning, Zhuoqi Tong

Renée Crown University Honors Thesis Projects - All

No abstract provided.

Developing Mechanisms To Deplete Cenexin In Vivo With Crispr-Cas13d, Denise Magny

Renée Crown University Honors Thesis Projects - All

No abstract provided.

American Drug Policy Reform Through A Rehabilitative Lens, Jordan Dacus

Renée Crown University Honors Thesis Projects - All

No abstract provided.

Dead Black Bodies And Social Media: Understanding Black Students' Experiences, Khloe Green

Renée Crown University Honors Thesis Projects - All

No abstract provided.

Evaluating The Relationship Between Attachment Orientation And Pain Tolerance, Laura Dickinson

Renée Crown University Honors Thesis Projects - All

No abstract provided.

Connecting The Brain To Behaviors: The Association Between The Mismatch Negativity And Attention To Detail, Valkyrie Hardy

Renée Crown University Honors Thesis Projects - All

No abstract provided.

Profiling Durable Anti-Tumor Memory T Cell Responses In Long-Term Melanoma Survivors, Jichang Han

Dartmouth College Ph.D Dissertations

While T-cell responses to cancer immunotherapy have been avidly studied,

long-lived memory has been poorly characterized. Of melanoma patients who

receive immunotherapy, long-term survivors are frequently found to develop

melanoma-associated vitiligo. Our prior work showed in a preclinical model that

vitiligo skin sustained a long-lived CD8+ resident memory T cell (TRM) population,

playing key roles in perpetuating anti-tumor immunity. However, the characteristics

and longevity of these memory T cells in melanoma survivors have not been defined.

In the present studies, we probed both the CD8+ and CD4+ T cell responses,

focusing on memory T cell responses in a cohort of …

Response And Molecular Control Of Cd8 T Cells During Infection And Cancer, Nicholas K. Preiss Dr.

Dartmouth College Ph.D Dissertations

CD8 T cells are potent immune effector cells capable of vast clonal expansion and clearance of infected or cancerous cells. After control of the pathogenic insult, CD8 T cells develop into quiescent, long-lived memory populations that are poised to mediate rapid protection upon reencounter with cognate antigen. These properties make control of CD8 T cell responses a highly desirable outcome of vaccine strategies and immunotherapy. Therefore, understanding how the effector function and memory differentiation of CD8 T cells are controlled at a molecular level is of great importance. In the context of infection with gammaherpesviruses (γHV), which form a latent …

Digest Of The Philadelphia College Of Osteopathic Medicine (2022 No. 1), Philadelphia College Of Osteopathic Medicine

PCOM Digest 2020s

The 2022 Vol 1 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Updates
• Advancing Alumni
• PCOM Board of Trustees Elects New Chairman Thomas J. Gravina
• Past PCOM Chairman John P. Kearney’s Legacy
• 125 Years Through 125 Stories: Six Reflections of Legendary PCOM Professors
• Edna K. Williams DO 1926: The Diminutive Osteopath with Mighty Hands and Spirit
• A Humble Genius: David A. Festinger, PhD
• Class Notes

The Effectiveness Of Teaching Life Skills Through Sport-Based Interventions For Youth At Risk, Mindy K. Mccarthy, Brandonn S. Harris, Katy Gregg

National Youth Advocacy & Resilience Journal

Youth who are placed at risk have been found to experience adjustment difficulties, behavioral problems, academic challenges, and/or mental health concerns (Moreau et al., 2012). One resource for these youth involve sport-based interventions designed to enhance psychosocial wellbeing. Using a single-subject design, the current study examined the effectiveness of a life skills program through sport in a sample of strategically identified youth (Danish, 2002); two additional mental skill modules were also implemented. Participants included three male adolescents. Using basketball to implement the program, life skills included managing emotions, goal setting, relaxation, confidence, mental preparation, and seeking help from others. Participants …

College Of Natural Sciences Newsletter, January 2022, College Of Natural Sciences

College of Natural Sciences Newsletters and Reports

Volume 3, Issue 1

Page 1 Dean's Message
Page 2 Awards & Recognition
Page 3 Outreach in Harrisburg, SD
Page 4 Geography Alumni Named Among 'Highly Cited Researchers', 53rd Annual Geography Convention
Page 5 Geography Convention Speakers, Brookings/SDSU Day
Page 6 Media Coverage of Natural Sciences
Page 7 Open PRAIRIE Data
Page 8 Fall 2021 Dean's List
Page 9 Fall 2021 Dean's List, cont.

Sex Based Differences In Muscle Quality Recovery Following One Week Of Lower Limb Immobilization And Subsequent Retraining, Ryan Girts

Electronic Theses and Dissertations, 2020-2023

The present project represents the second part of a two-phase clinical trial designed to comprehensively examine the effects of knee joint immobilization and recovery on skeletal muscle size, strength, and central nervous system plasticity in healthy males and females. The purpose of this study was to examine differences between sexes in the recovery of muscle quality, size, and strength in response to a resistance training-based rehabilitation program following one week of knee joint immobilization. Twenty-seven participants (males: n = 16, age = 22 ± 3 years, BM = 81.3 ± 14.8 kg, BMI = 25.0 ± 3.4 kg/cm2; females: n …

A Review Of Virus-Vectored Vaccines: Current Production Methods, Uses, Issues, And Future Perspectives, Jaden Marks

Biology and Microbiology Graduate Students Plan B Research Projects

Viral vector vaccines have recently risen to the forefront of vaccinology, but there are multiple factors that must be addressed before they achieve widespread approval and use. The concept of using viruses as vectors is not new, and numerous attempts to create vaccines that utilize virus vectors have been made in the past 25 years. Despite this, only one viral vector vaccine has gained full approval by the FDA. The goal of this review is to provide a comprehensive overview of the types of viral vector vaccines, production and purification methods, current and future viral vector vaccines, the issues and …

Review Of A Chimeric Hemagglutinin-Based Influenza Vaccine Approach, Whitney Muck

Biology and Microbiology Graduate Students Plan B Research Projects

Influenza virus has affected human populations for centuries, causing an acute respiratory effect on the body. Even with scientific advancements in vaccine research, there are still serious limitations to the influenza vaccine. Varying strains and the constant recombination of the influenza virus has caused annual influenza circulation to be difficult to predict. The ongoing 40 race to develop a more efficient vaccine to broadly protect against the variety of influenza strains remains a public health priority. Many strategies have been studied to improve the current vaccine. The use of a chimeric hemagglutinin-based vaccine is in the first stages of human …

Disruptions In Mitochondrial Fission And Fusion Associated With Charcot-Marie-Tooth Disease, Tristan Carivau

Biology and Microbiology Graduate Students Plan B Research Projects

Charcot-Marie-Tooth disease (CMT) is a group of hereditary peripheral neuropathies that can result from defects in a wide spectrum of genes. Some of these genetic defects disrupt mitochondrial fusion and fission in the peripheral neurons, ultimately leading poor axonal transport, which is one of the two major cellular phenotypes associated with CMT. While the mechanisms of how these mutated genes lead to disrupted axonal transport are not entirely understood, knowledge on this process, and the genes involved, has expanded substantially in the past decade. Currently, there is no cure for any form of CMT, and most treatments focuses on symptom …

Chimeric Antigen Receptor T-Cell Therapy In Cancer, Brian Stahl

Biology and Microbiology Graduate Students Plan B Research Projects

The development of immune-checkpoint-inhibitors (ICIs) has led to promising advancements in the treatment of patients with cancers, leading with the use of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) as a negative regulator of T cell activation in the mid-1990s. With the discovery of two ligands for program cell death protein-1 (PD-1) and promising checkpoint blockades in 2010, this sparked a cascade of hallmark immunotherapy drug patents, focusing on the mechanism of anti PD-1 and anti PD-L1 antibody inhibitors. Since then, chimeric antigen receptor (CAR)-engineered T (CAR-T) cells have emerged into the immuno-oncologic scene for treatment of hematological malignancies. These genetically …

A Review Of T1d: Prevalence, Current Therapies, And Cellular Therapies For The Future, Fahd Nazir

Biology and Microbiology Graduate Students Plan B Research Projects

Type 1 diabetes (T1D) is a chronic autoimmune disease that is characterized by the destruction of pancreatic β-cells and therefore, creating an insulin deficiency within the body. A deficiency of insulin within the body disrupts homeostatic glucose control leading to hyperglycemia and therefore, the need for exogenous insulin. Global incidence of T1D has been increasing for several decades and if current trajectory trends continue, incidence could double in the next year. In addition, diabetes is the seventh leading cause of death in the United States. Current therapies for the treatment of T1D include insulin injections, insulin-pump therapy, pancreatic transplant, and …

Alzheimer’S Disease: An Overview And Current Phase 3 Disease-Modifying Biologic Treatments, Haley Jahnke

Biology and Microbiology Graduate Students Plan B Research Projects

Alzheimer’s Disease (AD) is a degenerative brain disease caused by cell damage leading to brain changes such as amyloid plaques and neurofibrillary tangles. Alois Alzheimer was a clinical psychiatrist and neuroanatomist in Germany who first discovered Alzheimer’s Disease through microscopic viewing of Auguste D’s brain. Through more research following Dr. Alzheimer’s death, they began to stage AD. The six stages are: pre-clinical, mild, moderate, moderately severe, severe, and very severe. The current treatments approved by the FDA work to slow the progression of AD, rather than modify the disease. There are currently three Disease-Modifying Biologic clinical-trial drugs on the market …

Oral Microbiome And Its Effect On Respiratory Disease, Cole Pudwill

Biology and Microbiology Graduate Students Plan B Research Projects

The oral microbiome is composed of several different types of bacteria that can affect how our body operates. There are over 700 different bacteria living in our mouths. These bacteria can be helpful and harmful to our bodies, but they are synergistic in a way. There are several factors such as age, diet, smoking, and oral care that affect bacterial makeup. When there 10 is a significant difference, our immune system becomes weakened and respiratory disease set in. The immune system then works to return the microbiome back to homeostasis. When this fails, the diseases become chronic. Thus, the oral …

Undergraduate Bulletin, 2022-2023, Minnesota State University Moorhead

Undergraduate Bulletins (Catalogs)

No abstract provided.

Graduate Bulletin, 2022-2023, Minnesota State University Moorhead

Graduate Bulletins (Catalogs)

No abstract provided.

From Bedside To The Bench—A Call For Novel Approaches To Prognostic Evaluation And Treatment Of Empyema, Sophia Karandashova, Galina Florova, Steven Idell, Andrey A. Komissarov

School of Medical and Biological Sciences Faculty Publications and Presentations

Empyema, a severe complication of pneumonia, trauma, and surgery is characterized by fibrinopurulent effusions and loculations that can result in lung restriction and resistance to drainage. For decades, efforts have been focused on finding a universal treatment that could be applied to all patients with practice recommendations varying between intrapleural fibrinolytic therapy (IPFT) and surgical drainage. However, despite medical advances, the incidence of empyema has increased, suggesting a gap in our understanding of the pathophysiology of this disease and insufficient crosstalk between clinical practice and preclinical research, which slows the development of innovative, personalized therapies. The recent trend towards less …

Actualization Through Constraint: An Analysis Of Hegelian Self- Consciousness In Fascism- Exclusionary Expression And In Modular Orchestral Composition, Marisa Kaye Janke

2022 Symposium

How does a conscious entity become aware of itself and its place in the world? According to German Idealist Philosopher G.F.W. Hegel, there are required conditions that facilitate this movement of awareness. Recognition serves as a central requirement, for a consciousness cannot progress in an isolated space. Coexistence allows for referential points, and is often necessary for the actualization of concepts by providing social interactions wherein recognition both of and by others can occur.

This paper illustrates the progression of two such concepts, discourse and musical composition as forms of freedom “in-itself”. They are both imperfect for the promotion of …