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Phosphodiesterase (Pde) Iii Inhibitor, Cilostazol, Improved Memory Impairment In Aluminum Chloride-Treated Rats: Modulation Of Camp/Creb Pathway, Marwa Safar

Pharmacy

No abstract provided.

Uni Wrestling 2022-23, University Of Northern Iowa

Athletics Media Guides

Contents:

--- 2022-23 Schedule
--- Big 12 Conference
--- Head Coach Doug Schwab
--- Coaching Staff
--- 2021-22 Roster
--- Roster
--- 2021-22 Results
--- All-time Records
--- Lettermen

Uni Men's Basketball Media Guide 2022-23, University Of Northern Iowa

Athletics Media Guides

Contents:

Introduction --- 2
The Panthers --- 8
Coaching Staff --- 26
Staff Profiles --- 34
2021-22 Review --- 37
History --- 49
Postseason History --- 71
Results --- 92

Mormon Studies: A Critical History By Ronald Helfrich Jr., Roger Terry

BYU Studies

This short but dense critical history of Mormon studies is unique in several ways. First, author Ronald Helfrich Jr. is a self-described “Gentile” scholar who spent “probably far too many years,” including a year as a visiting professor in the Department of Sociology at Brigham Young University, researching and writing this history. Second, the book is surprisingly thorough. I have been the editorial director at BYU Studies for the past sixteen years and thought I had a fairly decent grasp of Mormon studies, past and present, but Helfrich repeatedly describes the work of historians and other scholars with whom I …

“To Moderate And Unify” The Role That Latter-Day Saint Citizen-Rhetors Can Play In Healing American Political Discourse, Kristine Hansen

BYU Studies

In the April 1997 general conference of The Church of Jesus Christ of Latter-day Saints, then-Elder Henry B. Eyring stated, “When the words of prophets seem repetitive, that should rivet our attention.” Repetition, he asserted, means the Lord’s servants are “warning the people, telling them the way to safety.” In both the October 2020 and the April 2021 general conferences, President Dallin H. Oaks stressed the importance of the rule of law and the best ways to participate as citizens in political processes. Although he focused on the United States, President Oaks reassured his global audience that the principles he …

Standardized Neon Organismal Data For Biodiversity Research, Daijiang Li, Sydne Record, Eric R. Sokol, Matthew E. Bitters, Melissa Y. Chen, Y. Anny Chung, Matthew R. Helmus, Ruvi Jaimes, Lara Jansen, Marta A. Jarzyna, Michael G. Just, Jalene M. Lamontagne, Brett A. Melbourne, Wynne Moss, Kari E. A. Norman, Stephanie M. Parker, Natalie Robinson, Bijan Seyednasrollah, Colin Smith, Sarah Spaulding, Thilina D. Surasinghe, Sarah K. Thomsen, Phoebe L. Zarnetske

Biology Faculty Research and Scholarship

Understanding patterns and drivers of species distribution and abundance, and thus biodiversity, is a core goal of ecology. Despite advances in recent decades, research into these patterns and processes is currently limited by a lack of standardized, high-quality, empirical data that span large spatial scales and long time periods. The NEON fills this gap by providing freely available observational data that are generated during robust and consistent organismal sampling of several sentinel taxonomic groups within 81 sites distributed across the United States and will be collected for at least 30 years. The breadth and scope of these data provide a …

An Immuno-Enrichment Free, Validated Quantification Of Tau Protein In Human Csf By Lc-Ms/Ms, Wade Self, Khader Awwad, John Paul Savaryn, Michael Schulz

Open Access Publications

Tau protein is a key target of interest in developing therapeutics for neurodegenerative diseases. Here, we sought to develop a method that quantifies extracellular tau protein concentrations in human cerebrospinal fluid (CSF) without antibody-based enrichment strategies. We demonstrate that the fit-for-purpose validated method in Alzheimer's Disease CSF is limited to quasi quantitative measures of tau surrogate peptides. We also provide evidence that CSF total Tau measures by LC-MS are feasible in the presence of monoclonal therapeutic antibodies in human CSF. Our Tau LC-MS/MS method is a translational bioanalytical tool for assaying target engagement and pharmacodynamics for anti-tau antibody drug development …

What Clonal Hematopoiesis Can Teach Us About Mds, Irenaeus C C Chan, Brian J Wiley, Kelly L Bolton

Open Access Publications

Clonal hematopoiesis (CH), defined as the clonal expansion of mutated hematopoietic stem and progenitor cells (HSPCs), is a common aging process. CH is a risk factor for the development of hematologic malignancies, most commonly myeloid neoplasms (MNs) including acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), and myeloproliferative neoplasm (MPN). Recent work has elucidated how the development and cellular fitness of CH is shaped by aging, environmental exposures, and the germline (inherited) genetic background of an individual. This in turn has provided valuable insights into the pathogenesis of MNs including MDS. Here, in this review, we discuss the genetic origins of …

High-Dimensional Analysis Reveals Distinct Endotypes In Patients With Idiopathic Inflammatory Myopathies, Erin M Wilfong, Todd Bartkowiak, Katherine N Vowell, Camille S Westlake, Jonathan M Irish, Peggy L Kendall, Leslie J Crofford, Rachel H Bonami

Open Access Publications

The idiopathic inflammatory myopathies (IIM) are a rare clinically heterogeneous group of conditions affecting the skin, muscle, joint, and lung in various combinations. While myositis specific autoantibodies are well described, we postulate that broader immune endotypes exist in IIM spanning B cell, T cell, and monocyte compartments. This study aims to identify immune endotypes through detailed immunophenotyping of peripheral blood mononuclear cells (PBMCs) in IIM patients compared to healthy controls. We collected PBMCs from 17 patients with a clinical diagnosis of inflammatory myositis and characterized the B, T, and myeloid cell subsets using mass cytometry by time of flight (CyTOF). …

Pleiotropic Effects Of Simvastatin And Losartan In Preclinical Models Of Post-Traumatic Elbow Contracture, Michael A David, Alex J Reiter, Chelsey L Dunham, Ryan M Castile, James A Abraham, Leanne E Iannucci, Ishani D Shah, Necat Havlioglu, Aaron M Chamberlain, Spencer P Lake

Open Access Publications

Elbow trauma can lead to post-traumatic joint contracture (PTJC), which is characterized by loss of motion associated with capsule/ligament fibrosis and cartilage damage. Unfortunately, current therapies are often unsuccessful or cause complications. This study aimed to determine the effects of prophylactically administered simvastatin (SV) and losartan (LS) in two preclinical models of elbow PTJC: an

Externalizing Personality Characteristics Define Clinically Relevant Subgroups Of Alcohol Use Disorder, Ildikó Kovács, Bernadett I Gál, Zsolt Horváth, Ildikó Demeter, Sándor Rózsa, Zoltán Janka, Róbert Urbán, Zsolt Demetrovics, Bálint Andó

Open Access Publications

AIMS: Higher levels of externalizing characteristics, i.e. impulsivity, novelty seeking and aggression, could contribute to the development, progression and severity of alcohol use disorder (AUD). The present study aims to explore whether these externalizing characteristics together have a potential group-forming role in AUD using latent profile analysis (LPA).

METHODS: Externalizing characteristics of 102 AUD patients were analyzed using LPA to explore the group-forming role of externalizing symptoms; groups were compared in terms of demographic and alcohol-related variables, indices of psychopathological, depressive and anxiety symptom severity.

RESULTS: LPA revealed and supported a two-group model based on externalizing symptoms. The group with …

Perceived Physical Fatigability Predicts All-Cause Mortality In Older Adults, Nancy W. Glynn, Theresa Gmelin, Sharon W. Renner, Yujia Susanna Qiao, Robert M. Boudreau, Mary F. Feitosa, Mary K. Wojczynski, Stephanie Cosentino, Stacy L. Andersen, Kaare Christensen, Anne B. Newman

Open Access Publications

BACKGROUND: Perceived physical fatigability is highly prevalent in older adults and associated with mobility decline and other health consequences. We examined the prognostic value of perceived physical fatigability as an independent predictor of risk of death among older adults.

METHODS: Participants (N = 2 906), mean age 73.5 [SD, 10.4] years, 54.2% women, 99.7% white enrolled in the Long Life Family Study, were assessed at Visit 2 (2014-2017) with 2.7 [SD, 1.0] years follow-up. The Pittsburgh Fatigability Scale (PFS), a 10-item, self-administered validated questionnaire (score range 0-50, higher = greater fatigability) measured perceived physical fatigability at Visit 2. Deaths post-Visit …

Amigo1 Promotes Axon Growth And Territory Matching In The Retina, Florentina Soto, Ning Shen, Daniel Kerschensteiner

Open Access Publications

Dendrite and axon arbor sizes are critical to neuronal function and vary widely between different neuron types. The relative dendrite and axon sizes of synaptic partners control signal convergence and divergence in neural circuits. The developmental mechanisms that determine cell-type-specific dendrite and axon size and match synaptic partners' arbor territories remain obscure. Here, we discover that retinal horizontal cells express the leucine-rich repeat domain cell adhesion molecule AMIGO1. Horizontal cells provide pathway-specific feedback to photoreceptors-horizontal cell axons to rods and horizontal cell dendrites to cones. AMIGO1 selectively expands the size of horizontal cell axons. When

Synthesis Of Highly Reactive Sulfone Iminium Fluorides And Their Use In Deoxyfluorination And Sulfur Fluoride Exchange Chemistry, James A. Vogel, Rania Hammami, Ara Ko, Hiya Datta, Yael N. Eiben, Karley J. Labenne, Ellis C. Mccarver, Ebrar Z. Yilmaz, Patrick R. Melvin

Chemistry Faculty Research and Scholarship

We report the synthesis of sulfone iminium fluorides (SIFs), a reactive class of sulfur(VI) molecules. The synthesis is tolerant of a variety of substituents on the sulfur and nitrogen components. The SIF reagents were applied to the deoxyfluorination of alcohols and carboxylic acids, providing high yields of fluorinated products in 60 s at room temperature. The SIF reagents were then utilized in sulfur fluoride exchange (SuFEx), creating the first ionic SuFEx products to date.

Rapid Radiation Of Zeiformes Revealed Through Comparison Of Jaw Morphologies, Jeffrey Peters

Master's Theses

Zeiformes (e.g., Dories, Lookdown dories, Tinselfishes, Oreos) are a deep (1000 m) to mid-water (100 m) marine order of acanthomorph fishes with a circumpolar distribution, and a fossil record extending back to the Late Cretaceous. The order consists of 33 species across six families. The phylogenetic placement of the Zeiformes within Teleostei has been debated, but more recent studies based on both molecular and morphological data place Zeiforms within Paracanthopterygii closely related to Gadiformes. Zeiformes are characterized by anal and dorsal profiles that contain a variable number of fin rays and spines. They are mostly deep bodied, highly compressed fishes …

Oncogenic Gq/11 Signaling Acutely Drives And Chronically Sustains Metabolic Reprogramming In Uveal Melanoma, Michael D Onken, Sarah E Noda, Kevin M Kaltenbronn, Cheryl Frankfater, Carol M Makepeace, Nikki Fettig, Kisha D Piggott, Philip L Custer, Joseph E Ippolito, Kendall J Blumer

Open Access Publications

Metabolic reprogramming has been shown to occur in uveal melanoma (UM), the most common intraocular tumor in adults. Mechanisms driving metabolic reprogramming in UM are poorly understood. Elucidation of these mechanisms could inform development of new therapeutic strategies for metastatic UM, which has poor prognosis because existing therapies are ineffective. Here, we determined whether metabolic reprogramming is driven by constitutively active mutant α-subunits of the heterotrimeric G proteins Gq or G11 (Gq/11), the oncogenic drivers in ∼90% of UM patients. Using PET-computed tomography imaging, microphysiometry, and GC/MS, we found that inhibition of oncogenic Gq/11 with the small molecule FR900359 (FR) …

Family History Of Breast Cancer And Mammographic Breast Density In Premenopausal Women, Yunan Han, Justin Xavier Moore, Graham A. Colditz, Adetunji T. Toriola

Open Access Publications

Importance: Family history of breast cancer (FHBC) and mammographic breast density are independent risk factors for breast cancer, but the association of FHBC and mammographic breast density in premenopausal women is not well understood.

Objectives: To investigate the association of FHBC and mammographic breast density in premenopausal women using both quantitative and qualitative measurements.

Design, Setting, and Participants: This single-center cohort study examined 2 retrospective cohorts: a discovery set of 375 premenopausal women and a validation set of 14 040 premenopausal women. Data from women in the discovery set was collected between December 2015 and October 2016, whereas data from …

Contralateral Limb Specificity For Movement Preparation In The Parietal Reach Region, Eric Mooshagian, Eric A. Yttri, Arthur D. Loewy, Lawrence H. Snyder

Open Access Publications

The canonical view of motor control is that distal musculature is controlled primarily by the contralateral cerebral hemisphere; unilateral brain lesions typically affect contralateral but not ipsilateral musculature. Contralateral-only limb deficits following a unilateral lesion suggest but do not prove that control is strictly contralateral: the loss of a contribution of the lesioned hemisphere to the control of the ipsilesional limb could be masked by the intact contralateral drive from the nonlesioned hemisphere. To distinguish between these possibilities, we serially inactivated the parietal reach region, comprising the posterior portion of medial intraparietal area, the anterior portion of V6a, and portions …

An Analysis Of Repeated High Intensity Efforts (Rhie) Across Different Competition Levels In Elite Rugby Union, Adam Sheehan, Shane Malone, Anthony Weldon, Aled Waters, Kieran Collins

Articles

The current investigation aimed to understand the differing positional demands across two elite rugby union competitions, with special reference to high-intensity effort (HIE) and repeated high-intensity effort (RHIE) activity. Four hundred and forty-one (n = 441) individual game files from thirty-five competitive games from the European Rugby Champions Cup (tier 1; n = 8) and PRO12 League (tier 2; n = 24) were analysed. Players’ locomotor profiles were recorded using wearable global positioning system microtechnology (10 Hz Catapult S5, Catapult Innovations, Australia). Locomotor activities were classified as running (4.4 ms1), high-speed running (5.5 ms1), accelerations (2 ms2) and decelerations (2 …

Protein With Negative Surface Charge Distribution, Bnr1, Shows Characteristics Of Adna‐Mimic Protein Andmay Be Involved In The Adaptation Of Burkholderia Cenocepacia, Ruth Dennehy, Niamh Duggan, Simon Dignam, Sarah Mccormack, Eugene Dillon, Jessica Molony, Maria Romano, Yueran Hou, Laura Ardill, Matthew Whelan, Zuzanna Drulis‐Kawa, Tadhg Ó'Cróinín, Miguel Valvano, Rita Berisio, Siobhán Mcclean

Articles

Adaptation of opportunistic pathogens to their host environment requires reprogramming of a vast array of genes to facilitate survival in the host. Burkholderia cenocepacia, a Gram-negative bacterium with a large genome of ∼8 Mb that colonizes environmental niches, is exquisitely adaptable to the hypoxic environment of the cystic fibrosis lung and survives in macrophages. We previously identified an immunoreactive acidic protein encoded on replicon 3, BCAS0292. Deletion of the BCAS0292 gene significantly altered the abundance of 979 proteins by 1.5-fold or more; 19 proteins became undetectable while 545 proteins showed ≥1.5-fold reduced abundance, suggesting the BCAS0292 protein is a …

Design, Spectroscopy, And Assessment Of Cholinesterase Inhibition And Antimicrobial Activities Of Novel Coumarin–Thiadiazole Hybrids, Dariusz Karcz, Karolina Starzak, Ewa Ciszkowicz, Katarzyna Lecka-Szlachta, Daniel Kami´ Nski, Bernadette Creaven, Anna Miło, Hollie Jenkins, Lidia Slusarczyk, Arkadiusz Matwijczuk

Articles

A novel series of coumarin–thiadiazole hybrids, derived from substituted coumarin-3- carboxylic acids was isolated and fully characterized with the use of a number of spectroscopic techniques and XRD crystallography. Several of the novel compounds showed intensive fluorescence in the visible region, comparable to that of known coumarin-based fluorescence standards. Moreover, the new compounds were tested as potential antineurodegenerative agents via their ability to act as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitors. Compared to the commercial standards, only a few compounds demonstrated moderate AChE and BuChE activities. Moreover, the novel derivatives were tested for their antimicrobial activity against a panel of …

Extreme Temperatures During Pregnancy And Adverse Birth Outcomes: Evidence From 2009 To 2018 U.S. National Birth Data, Gulcan Cil, Jiyoon Kim

Economics Faculty Research and Scholarship

We provide the first estimates of the impacts of prenatal exposure to extreme temperatures on infant health at birth using the latest national birth data from 2009 to 2018 from all U.S. states. We consistently find that an additional day with mean temperature greater than 80°F or less than 10°F increases preterm births and low birthweight. Strikingly, the adverse effects are borne disproportionately by Black and Hispanic mothers, suggesting that the projected increase in extreme temperatures may further exacerbate the existing birth health disparities across different race/ethnicity groups. We also contribute by investigating the impact of deviations from the normal …

Beyond Resistance: Therapeutic Itinerary In Saint-Louis-Du-Senegal Between Indigenous And Scientific Medicine, 1820–1920, Kalala J. Ngalamulume

History Faculty Research and Scholarship

Drawing on oral traditions and archival materials, this article examines the validity of claims made by the French colonial physicians and administrators that the African patients’ mistrust of and resistance to biomedicine had to do with their superstition, apathy, and ignorance, as well as with the pressure exercised upon them by healers, marabouts, and midwives. It argues that the African patients’ therapeutic choices were rational and were informed by their cultural history.

Variables That Affect Parental Goals For Visiting A Children’S Museum, Isabella M. Livingston

Honors Theses and Capstones

Children’s museums are informal educational environments that foster creativity, support sensory exploration, and provide places for both free play and learning (Gong et al., 2020). This study aimed to more fully understand parental goals for taking their children to a children’s museum, and how those goals varied based on characteristics known to play a role in how parents and children interact together. Subjects included 70 child-parent dyads. Each parent completed a demographic questionnaire, the Child Behavior Questionnaire-Very Short Form (Putnam & Rothbart, 2006) to assess temperament, and responded to an open-ended prompt related to visit intent. Dyads were then recorded …

Review Of 'Psychomotor Aesthetics: Movement And Affect In Modern Literature And Film', Tim Harte

Russian Faculty Research and Scholarship

No abstract provided.

The Negative Effects Of Adverse Childhood Experiences (Aces) On Behavioral Problems Of Children In Kinship Care: The Protective Role Of Kinship Caregivers' Mental Health, Yanfeng Xu, Merav Jedwab, Kerry Lee, Sue E. Levkoff

Graduate School of Social Work and Social Research Faculty Research and Scholarship

This study aims to examine the (a) prevalence of adverse childhood experiences (ACEs) among children in kinship care; (b) relationships between the number and type of ACEs and children’s internalizing and externalizing problems; and (c) moderating role of kinship caregivers’ mental health on the relationships between ACEs and children’s internalizing and externalizing problems. A sample of children in kinship care (N = 224) obtained from the National Survey of Child and Adolescent Well-Being II was used. Ordinary least squares regression models were conducted. Results indicated that neglect followed by parental substance abuse were found to be the most prevalent …

Female Superintendents And Negotiations: A Phenomenological Study Of The Influence Of Gender In The Midwest, Kathryn R. Blaha

Dissertations and Theses

Negotiation is a process wherein decisions are made between parties with different points of view and possibly conflicting interests (Caputo, 2019). Little is known about how women experience negotiation for salary and compensation. Studies associated with gender and negotiations have focused on the process or outcomes of the negotiation. While studies have identified a gender-based earnings gap, how women negotiate for compensation packages at the school superintendent level has not been studied. This qualitative Hermeneutical phenomenological study attempted to understand how female educational superintendents experience negotiations through description and meaning drawn from their lived experiences. By understanding how female school …

Electron Deficient Fluoroarenes: Bridging Deoxyfluorination And Anion-Π Interactions To Produce New Fluorination Reagents, Jordan Houston Kramer

Dissertations and Theses

Fluorination is a ubiquitous in modern materials and pharmaceuticals due to organofluorine compounds possessing unique physicochemical properties. However, this process is a demanding task due to difficulty in handling key reagents for selective fluorination. One strategy is the usage of deoxyfluorination reagents due to the wide availability of oxygen in many functional moieties. These reagents have allowed to production of new fluorinated materials and pharmaceuticals, yet the costs of several reagents and instabilities for others lead to restricted conditions, functional group tolerance, and safety risks for both users and the environment. Reported here is the culmination of a new hypothesis …

Towards A Model Of The Design Process For Games, John Healy, Charlie Cullen

Conference Papers

In this paper, we present an approach to studying the game design process by drawing upon general models of design to support research into the process of game design. Several general models of design exist to consider the processes through which designers work. Many of these fit within a structure of analysis, synthesis and evaluation that was first proposed by Christopher Jones in 1963 and later adapted by Bryan Lawson to account for the messy nature of design and the undertaking of these activities while negotiating between problem and solution. This paper proposes the adaptation of Lawson’s model of design …

Raman Spectroscopy Of Carotenoid Compounds For Clinical Applications—A Review, Joy Udensi, James Loughman, Ekaterina Loskutova, Hugh Byrne

Articles

Carotenoid compounds are ubiquitous in nature, providing the characteristic colouring of many algae, bacteria, fruits and vegetables. They are a critical component of the human diet and play a key role in human nutrition, health and disease. Therefore, the clinical importance of qualitative and quantitative carotene content analysis is increasingly recognised. In this review, the structural and optical properties of carotenoid compounds are reviewed, differentiating between those of carotenes and xanthophylls. The strong non-resonant and resonant Raman spectroscopic signatures of carotenoids are described, and advances in the use of Raman spectroscopy to identify carotenoids in biological environments are reviewed. Focus …