Digital Commons Network^™

Congressional Myopia In Biomedical Innovation Policy, W. Nicholson Price Ii

Reviews

Innovation policy is hard. Getting it right requires balancing incentives for developers, consumer access, rewards for later innovators, safety concerns, and other factors. This balance is vitally important and wickedly difficult—even when it’s the focus of concerted, careful, informed effort. How well should we expect it to go when innovation policy is made by accident? Enter The Accidental Innovation Policymakers, an illuminating new project by Professor Rachel Sachs. Sachs persuasively shows how Congress has repeatedly made substantial changes to innovation policy, seemingly without talking about, seriously considering, or even recognizing that it is doing so. There’s an asymmetry to this …

Criminal Acts And Basic Moral Equality, John A. Humbach

Elisabeth Haub School of Law Faculty Publications

Modern criminal justice presupposes that persons are not morally equal. On the contrary, those who do wrong are viewed by the law as less worthy of respect, concern and decent treatment: Offenders, it is said, “deserve” to suffer for their misdeeds. Yet, there is scant logical or empirical basis for the law's supposition that offenders are morally inferior. The usual reasoning is that persons who intentionally or knowingly do wrong are the authors and initiators of their acts and, as such, are morally responsible for them. But this reasoning rests on the assumption that a person's mental states, such as …

Uab Magazine - Spring/Summer 2022, University Of Alabama At Birmingham

UAB Magazine

No abstract provided.

Abortion And The Personhood Assumption: A New Defense Of Abortion On The Basis Of Self-Defense, Timothy Kirschenheiter

Wayne State University Dissertations

In this essay, I offer a new defense of abortion. I argue that even if we assume that the fetus is a person with full moral rights abortion is still generally morally permissible. For this argument, I rely on the concept of self-defense, arguing that abortion is morally permissible as a self-defensive action.

In Chapter II, I motivate the personhood assumption by finding and defending the strongest version of Don Marquis’s Future-Like-Ours Argument.

In Chapter III, I argue for the rejection of responsibility arguments in favor of the moral permissibility of abortion – the sort of arguments offered by Judith …

Ecological Predictors Of Sexual Well-Being In Women, Rachel Goutman

Wayne State University Dissertations

Previous research has shown that female sexuality continues to be suppressed in American society and as a result, women are not achieving their highest levels of sexual well-being (i.e., sexual self-concept, sexual assertiveness, and sexual satisfaction). Because sexual well-being is imperative to overall well-being, it is important for counseling psychologists to be sensitive to the potential role that ecological variables have on women’s current sexual well-being. Utilizing an ecological framework, the aims of this study were to deepen our understanding of how early life microsystem experiences relate to later sexual well-being in women, to assess how current macrosystem experiences of …

Childhood Sexual Abuse In Boys Under The Age Of 18: Nonverbal Disclosure Patterns Through Behavior, Matthew J. Luz

The Graduate Review

Adverse childhood experiences (ACE) include being exposed to or victimized by physical, emotional, or sexual abuse; if left untreated, traumas may disrupt normative biopsychosocial development. Childhood sexual abuse (CSA) is a phenomenon investigated by many researchers, however, the scientific community suspects CSA in boys is underreported. Since there are significant gender differences in CSA verbal disclosures, examining nonverbal disclosures in boys through overt, sexualized behaviors may help clinicians confirm suspected cases of CSA. Since most research investigates verbal disclosures of sexual abuse, this study will investigate nonverbal disclosure in boys between the ages of 6 through 10 using naturalistic observations …

Whither The Lofty Goals Of The Environmental Laws?: Can Statutory Directives Restore Purposivism When We Are All Textualists Now?, Stephen M. Johnson

Articles

Congress set ambitious goals to protect public health and the environment when it enacted the federal environmental laws through bipartisan efforts in the 1970s. For many years, the federal courts interpreted the environmental laws to carry out those enacted purposes. Over time, however, courts greatly reduced their focus on the environmental and public health purposes of the environmental laws when interpreting those statutes due to the rise in textualism, the declining influence of the Chevron doctrine, and the increasing willingness of courts to defer to agency underenforcement of statutory responsibilities across all regulatory statutes.

In 2020, the Environmental Protection Network, …

Extending Plasma Proteome Coverage To Enable Biomarker Discovery, Jordan Bruce Burton

Wayne State University Dissertations

Two features make plasma a valued source of health information: First, plasma contains secreted proteins from all tissues in the body and can, therefore, provide information about the health status of all tissues. Second, plasma is available in large quantity using a minimally invasive procedure that is well tolerated. The status of plasma as a valued source of health information is matched by the difficulty in extracting proteome information from the samples. Using state of the art instrumentation a standard analysis of plasma yields quantitative information on approximately 300 proteins. Extreme fractionation strategies coupled with increased mass spectrometry time extends …

Childhood Adversity And Alexithymia: Implications For Health Status In An Urban Police Sample, Christopher P. Urbanik

Wayne State University Dissertations

American law enforcement is regarded as one of the most stressful occupations in the United States, involving repeated exposure to threatening or challenging encounters and the risk of severe injury and death. A voluminous literature has documented various psychophysiological implications of police stress, including morbidity and premature mortality. Adverse childhood experiences (ACEs) are potentially traumatic stressors during one’s formative years, such as abuse, neglect, and household violence and dysfunction. ACEs have been linked to increased mental and physical health risks, yet ACEs have not been studied in police officers. Given the increase in the level of stress experienced by today’s …

The State Of The Art Of Information Integration In Space Applications, Zhuming Bi, K. L. Yung, Andrew W.H. Ip., Yuk Ming Tang, Chris W.J. Zhang, Li Da Xu

Information Technology & Decision Sciences Faculty Publications

This paper aims to present a comprehensive survey on information integration (II) in space informatics. With an ever-increasing scale and dynamics of complex space systems, II has become essential in dealing with the complexity, changes, dynamics, and uncertainties of space systems. The applications of space II (SII) require addressing some distinctive functional requirements (FRs) of heterogeneity, networking, communication, security, latency, and resilience; while limited works are available to examine recent advances of SII thoroughly. This survey helps to gain the understanding of the state of the art of SII in sense that (1) technical drivers for SII are discussed and …

Biom 4730 / Mech 4365: Biomaterials (Syllabus), Joel D. Bumgardner

Biomedical Engineering Syllabi Archive

Course Description: Synthetic materials and their interaction with the physiological environment; methods to design and study materials that are compatible with natural tissue.

Time Course Investigation Of The Dermal Leukocyte Response To Lipoteichoic Acid In Chickens, Ian M. Gilbert, Jossie M. Santamaria, Gisela F. Erf

Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences

Lipoteichoic acid (LTA) is a cell-wall polymer in Gram-positive bacteria that stimulates inflammation. Few studies have investigated in vivo immune response to LTA, and none of the in vivo studies have been performed in birds. For this project, the pulp (a skin derivative) of growing feathers (GF) of chickens was used to investigate the in vivo effects of intradermally injected LTA. In Study 1, GF of chickens were injected with 10 μL of differing concentrations of LTA (0.1, 1.0, 10, 100 or 250 μg LTA/mL; 3 chickens/dose). Growing feathers were plucked before injection (0 h) and at 6, 24, 48, …

A Mini-Course On The Our Father/Lord's Prayer: Lecture Notes And Workshop And Discussion Topics [Lecture Notes], Scott Gambrill Sinclair

The Scott Sinclair Lecture Notes Collection

Lecture notes on a series of talks by Scott G. Sinclair's on his version of the Historical Jesus.

The Life, Teaching, Death, And Resurrection Of Jesus Of Nazareth And Some Implications [Lecture Notes], Scott Gambrill Sinclair

The Scott Sinclair Lecture Notes Collection

Lecture notes on a series of talks by Scott G. Sinclair's on his version of the Historical Jesus.

The Role Of Emotion In Constitutional Theory, J. Joel Alicea

Scholarly Articles

Although the role of emotion in law has become a major field of scholarship, there has been very little attention paid to the role of emotion in constitutional theory. This Article seeks to fill that gap by providing an integrated account of the role of emotion within the individual, how emotion affects constitutional culture, and how constitutional culture, properly understood, should affect our evaluation of major constitutional theories.

The Article begins by reconstructing one of the most important and influential accounts of emotion in the philosophical literature: that of Thomas Aquinas. Because Aquinas’s description of the nature of emotion accords …

Giardial Lipid Rafts Share Virulence Factors With Secreted Vesicles And Participate In Parasitic Infection In Mice, Brian I. Grajeda, Atasi De Chatterjee, Carmen M. Villalobos, Breanna C. Pence, Cameron C. Ellis, Vanessa Enriquez, Sourav Roy, Sukla Roychowdhury, Aaron K. Neumann, Igor C. Almeida, Steven E. Patterson, Siddhartha Das

Pathology Research and Scholarship

Giardia lamblia, a protozoan parasite, is a major cause of waterborne infection, worldwide. While the trophozoite form of this parasite induces pathological symptoms in the gut, the cyst form transmits the infection. Since Giardia is a noninvasive parasite, the actual mechanism by which it causes disease remains elusive. We have previously reported that Giardia assembles cholesterol and GM1 glycosphingolipid-enriched lipid rafts (LRs) that participate in encystation and cyst production. To further delineate the role of LRs in pathogenesis, we isolated LRs from Giardia and subjected them to proteomic analysis. Various cellular proteins including potential virulence factors-e.g., giardins, variant surface …

Integrins As Therapeutic Targets For Sars-Cov-2, Timothy E. Gressett, Danielle Nader, Juan Pablo Robles, Tione Buranda, Steven W. Kerrigan, Gregory Bix

Pathology Research and Scholarship

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense, single-stranded RNA virus of the genus Betacoronavirus. Its genome is composed of four structural proteins known as spike (S), envelope (E), membrane (M), and nucleocapsid (N), of which E, M, and N are integrated into the viral envelope. The S glycoprotein, which protrudes from the surface of mature virions as a spike, is essential for virus attachment, fusion, and entry into the host cell. While the relationship between the spike protein of SARS-CoV-2 and the angiotensin- converting enzyme 2 (ACE2) receptor has been readily established, the S1 subunit also …

The Giant Axon Of The Squid: A Simple System For Axonal Transport Studies, Joseph A. Degiorgis, Marcus Jang, Elaine L. Bearer

Pathology Research and Scholarship

The squid giant axon has a long history of being a superb experimental system in which to investigate a wide range of questions concerning intracellular transport. In this protocol we describe the method used for dissecting the axon to preserve its viability in vitro, and the technique for injecting exogenous materials into the living axon. Now that the squid genome is emerging, and the CRISPR/cas9 system has been successfully applied to knock-out squid genes, the giant axon will resume its place in the scientific pantheon of powerful experimental systems in which to address biological questions pertaining to all eukaryotes.

Physical Therapy Mangement Of A 23-Year-Old Male Experiencing Cervicalgia And Headaches, Matthew Thomas Grasser

Physical Therapy Scholarly Projects

Background and Purpose. Headaches are one of the most common disorders globally, with a potential for major disability. According to the World Health Organization (WHO) roughly 50% of the population globally are affected by headaches. The WHO states that 50-75% of adults within the last year report neck pain associated with headaches, while 30 % of these individuals reported they were experiencing migraines. The main types of headaches include tension, cluster, migraine and cervicogenic. The purpose of this case report is to see if my patient experienced a positive outcome while in my care with the use of manual therapy …

A Right Atrial Mass With Fever And Cutaneous Nodules, Feng Gao, Stephanie Koh, Sara Taveras-Alam, Umair Khalid

Faculty, Staff and Student Publications

Primary cardiac tumors, although exceedingly rare, should be considered in the differential diagnosis during workup of any cardiac mass. Extranodal cardiac lymphomas have a natural aggressive course due to delayed diagnosis. We present a 71-year-old male with a dual-chamber pacemaker who presented with fevers and new cutaneous nodules. He was found to have a right atrial primary anaplastic large-cell lymphoma and had a complete metabolic response after chemotherapy. Our case highlights the importance of a multimodality approach in the diagnosis of cardiac tumors and during follow-up after treatment.

Introduction To Social Work: A Look Across The Profession, James Langford, Craig Keaton

Mavs Open Press Open Educational Resources - Archive

This book takes students on a journey through many but not all of the different possibilities in social work. Social work is a profession focused on helping people live their best lives by working with people individually, at the family level, in groups and communities. Help may be in the form of connecting people to resources to address challenges, providing therapy, and advocating for changes in laws that affect individuals', couples', families' and communities' well-being. Students will learn the profession's exciting history and ways we help today. [Visit the books' Pressbooks page to download the OER in other formats or …

Strategies For Success In Nursing School: From Start To Finish, Leslie Ann Jennings, Raeanna Jeffers, Laura Haygood, Craig Keaton

Mavs Open Press Open Educational Resources - Archive

This textbook was created for nursing intended students to provide a single resource for the most fundamental tools for success. The chapters and activities provide keys for success both inside and outside of the classroom, starting with time management and moving through study and test taking strategies. Self-care is a focus to help students identify how to care for their best self, which will carry on through the nursing profession to avoid burn out. Using the library is foundational for students to be successful with their coursework and evidence based practice in the future. Finally, there is a section on …

Not For Human Consumption: How To Alleviate The Cruelty Plaguing The Pet Food Industry In The United States, Bailey Frank

Animal Law Review

More than 37 billion dollars of pet food was sold in 2019, a sum that increased to approximately 42 billion dollars in 2020. In fact, forty-two of the fifty states have pet food facilities producing more than 3 million tons of animal-based pet food ingredients. Yet, in the last decade, multiple pet food brands have been found to contain trace amounts of euthanasia ‘death drugs’ and are made from 3D or 4D animals — those that are dead, dying, diseased, or disabled. While this can often cause sickness or death in companion animals, an equally urgent issue is the welfare …

Power In Numbers: An Abundance Of Small Corals Responsible For Storing Over Half Of The Carbon Stored By All Alaskan Primnoa Pacifica Deep-Sea Corals, Sylvie Alexander

Scripps Senior Theses

Gorgonian deep-sea corals (DSCs) are biologically linked to ocean carbon cycling converting ocean carbon to gorgonin and calcite in their skeletons. As such, gorgonian DSCs likely accumulate and store carbon in their skeleton throughout their lifespans, acting as carbon sinks on historic timescales. Yet, DSC carbon storage hasn’t been investigated to date. This study evaluates gorgonian DSC carbon storage capacity through an evaluation of the carbon stored by Alaskan Primnoa pacifica corals. The development of a model relating coral height to biomass in specimens with this data available was used to determine biomass values in a suite of Alaskan P. …

The Legal Character And Practical Implementation Of A Trips Waiver For Covid-19 Vaccines, Andrew D. Mitchell, Antony Taubman, Theodore Samlidis

Fordham Intellectual Property, Media and Entertainment Law Journal

Almost two years after initial proposals for a COVID-19 waiver of TRIPS obligations, a Ministerial decision adopted at the 12th Ministerial Conference in June 2022 waived obligations under Article 31(f) and the System for pharmaceutical export under the TRIPS Annex, and clarified existing options under TRIPS for increasing access to COVID-19 vaccines. As support for a more expansive pandemic waiver continues and WTO waivers remain legitimate mechanisms under WTO law, further waivers may be contemplated as viable options to address obstacles identified in the current pandemic or future health crises. This article explores what additional options are or may be …

Analyzing College On-Campus Residency Agglomeration Benefits And Their Impact On Student Outcomes, Emily Pedace

Scripps Senior Theses

Economies of agglomeration have been shown to increase productivity in part due to technological/ knowledge spillovers. I look at public colleges and universities in California and Texas to examine if students living on-campus can generate enough agglomeration to boost productivity in the students. I use a unique data set with information collected from Common Data Sets, self-reported by the schools. When using an OLS regression with the averages of these variables, higher averages of on-campus residence is correlated to higher average graduation and retention rates for Texas and California. When using a fixed effects panel regression, I find changes in …

The Economic And Social Decline Of Women's Colleges Across The United States, Alexandra Isabelle Rivasplata

Scripps Senior Theses

Women have been attending college at a greater rate than men for several decades. However, women’s colleges have been shutting down or transitioning to coeducation at incredibly high rates. Literature demonstrates the importance of women’s colleges due to their benefits on students’ future career success and psychological wellbeing. However, there is less research concerning the decline of women's colleges, and none regarding the economic and quantitative factors influencing their closures. Using a newly constructed, completely original data set, I perform a logistic regression and analyze variables related to the survival of women’s colleges. I find a high statistical significance of …

Our Silence Will Not Protect Us . . . And Neither Will J. Edgar Hoover: Reclaiming Critical Race Theory Under The New Mccarthyism, Christina Hsu Accomando, Kristin J. Anderson

Humboldt Journal of Social Relations

The right-wing attack against critical race theory is the latest manufactured panic designed to whip up supporters of a party beholden to Donald Trump. Since late 2020, hundreds of measures have been introduced across the U.S. to ban antiracism education, critical race theory, the 1619 Project, and any understanding of racism as systemic and embedded in U.S. history and law. While an understandable reaction of educators is to declare that they are not teaching critical race theory, our position is to reclaim critical race theory for the powerful lens it offers in understanding the history of the U.S., the protracted …

Volume 44: Full Issue

Humboldt Journal of Social Relations

Humboldt Journal of Social Relations: Teaching in the Wake of Trump. Volume 44.

A Choice Based Art Classroom With The Application Of The Multiple Intelligence Theory And The Impact At The Elementary Level, Kelly Nyhammer

All Electronic Theses and Dissertations

This literature review was guided by the research question, “How can the application of the multiple intelligence theory impact a choice based art classroom at the elementary level?” Data collected from this research found increased in student motivation and task engagement when choice and preferred learning styles are used in the classroom. Teacher structure of selection choice and aid in guiding students to build capacity for choice was suggested within younger students. The connection between providing students choice in the classroom and the incorporation of implementing the multiple intelligences has research backing proving that it promotes student engagement and reduces …